nitrous oxide has been researched along with Peripheral Nerve Diseases in 40 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the rat chronic constriction injury (CCI) pain model, we evaluated whether nitrous oxide (N2O), a gas shown to have potent anti-hyperalgesic properties, may alleviate neuropathic pain." | 7.76 | A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. ( Bessière, B; Chateauraynaud, J; Laboureyras, E; Laulin, JP; Simonnet, G, 2010) |
| "N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi." | 5.62 | [Thromboembolisms due to recreational use of nitrous oxide]. ( de Metz, J; Fokkema, TMM; Kuipers, RS; Oomens, T; Riezebos, RK; van den Bogaard, B; van Nieuwenhuizen, RC, 2021) |
| "Using the rat chronic constriction injury (CCI) pain model, we evaluated whether nitrous oxide (N2O), a gas shown to have potent anti-hyperalgesic properties, may alleviate neuropathic pain." | 3.76 | A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. ( Bessière, B; Chateauraynaud, J; Laboureyras, E; Laulin, JP; Simonnet, G, 2010) |
| "All cases of neurological disorders related to nitrous oxide recreational use reported to the Hauts-de-France addictovigilance center between January 2019 and August 2020 were selected." | 1.72 | Myeloneuropathy induced by recreational nitrous oxide use with variable exposure levels. ( Bordet, R; Caous, AS; Carton, L; Deheul, S; Gautier, S; Karam, A; Kuchcinski, G; Largeau, B; Potey, C; Tard, C, 2022) |
| "N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi." | 1.62 | [Thromboembolisms due to recreational use of nitrous oxide]. ( de Metz, J; Fokkema, TMM; Kuipers, RS; Oomens, T; Riezebos, RK; van den Bogaard, B; van Nieuwenhuizen, RC, 2021) |
| "Nitrous oxide misuse can cause a severe but potentially reversible subacute myeloneuropathy." | 1.62 | Nitrous oxide-induced myeloneuropathy. ( Barnes, S; Blair, C; Bolitho, S; Cremer, P; Lu, Z; Michael Halmagyi, G; Offord, J; Palavra, N; Sutherland, E; Swart, G; Yogendran, S, 2021) |
| "Nitrous oxide is a common adjuvant to anaesthesia in the ED but it not often thought of as a drug of abuse." | 1.36 | Peripheral neuropathy following nitrous oxide abuse. ( Richardson, PG, 2010) |
| "Nitrous oxide toxicity has been reported in medical and dental professions and a few cases of myeloneuropathy due to induced vitamin B12 deficiency have been reported." | 1.30 | Myeloneuropathy from whipped cream bulbs presenting as conversion disorder. ( Brett, A, 1997) |
| "As nitrous oxide is known to cause a neuropathy similar to that seen in pernicious anaemia, we postulate that nitrous oxide analgesia combined with low B12 levels was the cause of the marked neuropathy in these patients." | 1.30 | Sickle cell disease and nitrous oxide-induced neuropathy. ( Adepegba, T; Ogundipe, O; Pearson, MW; Slater, NG; Westerdale, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (35.00) | 18.7374 |
| 1990's | 5 (12.50) | 18.2507 |
| 2000's | 1 (2.50) | 29.6817 |
| 2010's | 8 (20.00) | 24.3611 |
| 2020's | 12 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berling, E | 1 |
| Fargeot, G | 1 |
| Aure, K | 1 |
| Tran, TH | 1 |
| Kubis, N | 1 |
| Lozeron, P | 1 |
| Zanin, A | 1 |
| Yang, SL | 1 |
| Du, XQ | 1 |
| Hu, YD | 1 |
| Wang, EC | 1 |
| Ye, Q | 1 |
| Largeau, B | 1 |
| Karam, A | 1 |
| Potey, C | 1 |
| Caous, AS | 1 |
| Tard, C | 1 |
| Carton, L | 1 |
| Kuchcinski, G | 1 |
| Gautier, S | 1 |
| Deheul, S | 1 |
| Bordet, R | 1 |
| Qin, X | 1 |
| Kang, L | 1 |
| Liu, X | 1 |
| Jin, J | 1 |
| Hu, F | 1 |
| Lu, W | 1 |
| Deng, Y | 1 |
| Chen, QY | 1 |
| Dang, J | 1 |
| Neveu, J | 1 |
| Perelman, S | 1 |
| Suisse, G | 1 |
| Monpoux, F | 1 |
| Winstock, AR | 1 |
| Ferris, JA | 1 |
| Lee, M | 1 |
| Abbas, A | 1 |
| Lee, O | 1 |
| Record, CJ | 1 |
| Moodley, KK | 1 |
| Nirmalananthan, N | 1 |
| Oomens, T | 1 |
| Fokkema, TMM | 1 |
| van den Bogaard, B | 1 |
| de Metz, J | 1 |
| van Nieuwenhuizen, RC | 1 |
| Riezebos, RK | 1 |
| Kuipers, RS | 1 |
| Vodovar, D | 1 |
| Care, W | 1 |
| Batisse, A | 1 |
| Dufayet, L | 1 |
| Dang, XT | 1 |
| Nguyen, TX | 1 |
| Nguyen, TTH | 1 |
| Ha, HT | 1 |
| Mosalski, S | 1 |
| Tanner, A | 1 |
| Shiner, CT | 1 |
| Pedersen, OB | 1 |
| Hvas, AM | 1 |
| Grove, EL | 1 |
| Swart, G | 1 |
| Blair, C | 1 |
| Lu, Z | 1 |
| Yogendran, S | 1 |
| Offord, J | 1 |
| Sutherland, E | 1 |
| Barnes, S | 1 |
| Palavra, N | 1 |
| Cremer, P | 1 |
| Bolitho, S | 1 |
| Michael Halmagyi, G | 1 |
| Kaski, D | 1 |
| Kumar, P | 1 |
| Murphy, E | 1 |
| Warner, TT | 1 |
| Hew, A | 1 |
| Lai, E | 1 |
| Radford, E | 1 |
| Francis, A | 1 |
| Crossley, R | 1 |
| Brady, S | 1 |
| Massey, TH | 1 |
| Pickersgill, TT | 1 |
| J Peall, K | 1 |
| Li, HT | 1 |
| Chu, CC | 1 |
| Chang, KH | 1 |
| Liao, MF | 1 |
| Chang, HS | 1 |
| Kuo, HC | 1 |
| Lyu, RK | 1 |
| Bessière, B | 1 |
| Laboureyras, E | 1 |
| Chateauraynaud, J | 1 |
| Laulin, JP | 1 |
| Simonnet, G | 1 |
| Richardson, PG | 1 |
| Singer, MA | 1 |
| Lazaridis, C | 1 |
| Nations, SP | 1 |
| Wolfe, GI | 1 |
| Chanarin, I | 1 |
| Dinn, JJ | 1 |
| Weir, DG | 1 |
| McCann, S | 1 |
| Reed, B | 1 |
| Wilson, P | 1 |
| Scott, JM | 1 |
| Nevins, MA | 1 |
| Kreul, JF | 1 |
| Hayden, PJ | 1 |
| Hartemink, RJ | 1 |
| Nicholson, GA | 1 |
| Blanco, G | 1 |
| Peters, HA | 1 |
| Lunsford, JM | 1 |
| Wynn, MH | 1 |
| Kwan, WH | 1 |
| Nestor, PJ | 1 |
| Stark, RJ | 1 |
| Lai, NY | 1 |
| Silbert, PL | 1 |
| Erber, WN | 1 |
| Rijks, CJ | 1 |
| Brett, A | 1 |
| Ogundipe, O | 1 |
| Pearson, MW | 1 |
| Slater, NG | 1 |
| Adepegba, T | 1 |
| Westerdale, N | 1 |
| Layzer, RB | 2 |
| Adornato, BT | 1 |
| Sahenk, Z | 1 |
| Mendell, JR | 1 |
| Couri, D | 1 |
| Nachtman, J | 1 |
| Fishman, RA | 1 |
| Schafer, JA | 1 |
| Holloway, KL | 1 |
| Alberico, AM | 1 |
| Lampert, BA | 1 |
| Shimizu, T | 1 |
| Nishimura, Y | 1 |
| Fujishima, Y | 1 |
| Miyajima, H | 1 |
| Honda, N | 1 |
| Heyer, EJ | 1 |
| Simpson, DM | 1 |
| Bodis-Wollner, I | 1 |
| Diamond, SP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Assessment of Neurological Recovery in Patients Following Nitrous Oxide Abuse[NCT05714917] | 100 participants (Anticipated) | Observational | 2023-04-01 | Not yet recruiting | |||
| Epidemiology of Neurological Complications to Nitrous Oxide Poisoning[NCT05329909] | 135 participants (Anticipated) | Observational | 2022-04-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitrous oxide and Peripheral Nerve Diseases
| Article | Year |
|---|---|
The effects of nitrous oxide on cobalamins, folates, and on related events.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Analgesia; Animals; Carbon; Cell D | 1982 |
[Subacute myeloneuropathy after abuse of nitrous oxide: an electron microscopic study on the peripheral nerve].
Topics: Adult; Demyelinating Diseases; Humans; Male; Microscopy, Electron; Nitrous Oxide; Peripheral Nervous | 1989 |
38 other studies available for nitrous oxide and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Nitrous oxide-induced predominantly motor neuropathies: a follow-up study.
Topics: Adolescent; Ataxia; Follow-Up Studies; Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Re | 2022 |
[Nitrous oxide abuse-induced myelopathy, peripheral neuropathy, and mental disorders：a case series].
Topics: Humans; Mental Disorders; Nitrous Oxide; Peripheral Nervous System Diseases; Research; Spinal Cord D | 2021 |
Myeloneuropathy induced by recreational nitrous oxide use with variable exposure levels.
Topics: Adolescent; Adult; Ataxia; Female; Humans; Male; Nervous System Diseases; Nitrous Oxide; Peripheral | 2022 |
Acute nitrous oxide-induced neuropathy mimicking Guillain-Barré syndrome.
Topics: Guillain-Barre Syndrome; Homocysteine; Humans; Neural Conduction; Nitrous Oxide; Peripheral Nervous | 2022 |
Severe hyperhomocysteinemia and peripheral neuropathy as side effects of nitrous oxide in two patients with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Anesthetics, Inhalation; Female; Humans; Hyperhomocysteinemia; Male | 2019 |
Nitrous oxide causes peripheral neuropathy in a dose dependent manner among recreational users.
Topics: Adult; Age Factors; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Health Survey | 2020 |
Nitrous oxide-induced motor-predominant axonal peripheral neuropathy: A phenotype distinct from isolated vitamin B12 deficiency.
Topics: Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Phenotype; Vitamin B 12; Vitamin B 12 Def | 2021 |
[Thromboembolisms due to recreational use of nitrous oxide].
Topics: Female; Humans; Illicit Drugs; Male; Nervous System Diseases; Nitrous Oxide; Peripheral Nervous Syst | 2021 |
Vitamin B12 inactivation may not be the only cause of acquired peripheral neuropathy in chronic nitrous oxide users.
Topics: Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Vitamin B 12 | 2022 |
Nitrous Oxide-Induced Neuropathy among Recreational Users in Vietnam.
Topics: Adolescent; Adult; Humans; Nervous System Diseases; Nitrous Oxide; Peripheral Nervous System Disease | 2021 |
Recreational nitrous oxide misuse is resulting in serious neurological impairment and persistent disability among users.
Topics: Australia; Disability Evaluation; Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Recreat | 2021 |
A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism.
Topics: Adolescent; Adult; Humans; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Pulmonary Emboli | 2021 |
Nitrous oxide-induced myeloneuropathy.
Topics: Adult; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Peripheral Nervous System Diseases; Vitami | 2021 |
Iatrogenic B12-deficient peripheral neuropathy following nitrous oxide administration for functional tonic leg spasm: A case report.
Topics: Adult; Humans; Iatrogenic Disease; Leg; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Spa | 2017 |
Nitrous oxide abuse presenting with acute psychosis and peripheral neuropathy.
Topics: Analgesics, Non-Narcotic; Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Psychoses, Subs | 2018 |
Subacute progressive sensorimotor symptoms.
Topics: Adult; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseas | 2019 |
Nitrous oxide misuse and vitamin B12 deficiency.
Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Humans; Magnetic Re | 2016 |
Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan.
Topics: Adult; Case-Control Studies; Female; Humans; Male; Motor Neurons; Neural Conduction; Nitrous Oxide; | 2016 |
A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Functional Laterality; Male; Naltrexone; Narcotic Antag | 2010 |
Peripheral neuropathy following nitrous oxide abuse.
Topics: Adult; Humans; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Substance-Related Disorders | 2010 |
Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review.
Topics: Adult; Anemia, Pernicious; Anesthetics, Inhalation; Female; Humans; Leg; Magnetic Resonance Imaging; | 2008 |
Methyl group deficiency in nerve tissue: a hypothesis to explain the lesion of subacute combined degeneration.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cercopithecus; Disease Models, A | 1980 |
Neuropathy after nitrous oxide abuse.
Topics: Female; Humans; Male; Neuromuscular Diseases; Nitrous Oxide; Peripheral Nervous System Diseases; Sub | 1980 |
Neuropathy and nitrous oxide exposure.
Topics: Dentists; Humans; Nitrous Oxide; Occupational Diseases; Peripheral Nervous System Diseases | 1981 |
Myeloneuropathy due to nitrous oxide.
Topics: Adult; Burns; Humans; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Spinal Cord Diseases | 1983 |
Myeloneuropathy and macrocytosis associated with nitrous oxide abuse.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Humans; Male; Nitrous Oxide; Peripheral Nervous Sy | 1983 |
Nitrous oxide-induced myeloneuropathy.
Topics: Adult; Humans; Hypesthesia; Leg; Male; Muscle Hypotonia; Muscles; Nitrous Oxide; Paresthesia; Periph | 1983 |
Vitamin B12 myeloneuropathy precipitated by nitrous oxide anaesthesia.
Topics: Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Female; Humans; Nitrous Oxide; Peripheral Ner | 1996 |
"Nanging": another cause of nitrous oxide neurotoxicity.
Topics: Adult; Female; Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Substance-Related Disorder | 1997 |
Myeloneuropathy from whipped cream bulbs presenting as conversion disorder.
Topics: Adult; Central Nervous System Diseases; Conversion Disorder; Diagnosis, Differential; Female; Humans | 1997 |
Sickle cell disease and nitrous oxide-induced neuropathy.
Topics: Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Female; Humans; Male; Nitrous Oxide; Periphera | 1999 |
Myeloneuropathy after prolonged exposure to nitrous oxide.
Topics: Adult; Anesthesia, Dental; Arm; Dental Technicians; Dentists; Erectile Dysfunction; Humans; Leg; Mal | 1978 |
Nitrous oxide and vitamin B12.
Topics: Humans; Hypesthesia; Nitrous Oxide; Peripheral Nervous System Diseases; Vitamin B 12 Deficiency | 1978 |
Polyneuropathy from inhalation of N2O cartridges through a whipped-cream dispenser.
Topics: Adult; Dairy Products; Electromyography; Female; Humans; Neural Conduction; Nitrous Oxide; Periphera | 1978 |
Neuropathy following abuse of nitrous oxide.
Topics: Adult; Dentistry; Humans; Male; Medical Laboratory Science; Neural Conduction; Nitrous Oxide; Periph | 1978 |
Postoperative myeloneuropathy: a preventable complication in patients with B12 deficiency.
Topics: Female; Humans; Intervertebral Disc Displacement; Middle Aged; Nitrous Oxide; Peripheral Nervous Sys | 1990 |
Multiple nerve palsies after anesthesia--a complication of nitrous oxide use?
Topics: Adult; Anesthesia, General; Humans; Male; Nitrous Oxide; Peripheral Nervous System Diseases | 1989 |
Nitrous oxide: clinical and electrophysiologic investigation of neurologic complications.
Topics: Adult; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Humans; Male; Median Nerve; Nerv | 1986 |