nitrous oxide has been researched along with Nervous System Disorders in 58 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Excerpt | Relevance | Reference |
---|---|---|
"02 mg X kg-1) on succinylcholine-induced fasciculations and myoglobinaemia was studied in 64 healthy children (ages two to nine years), anaesthetized with halothane, nitrous oxide and oxygen." | 7.67 | Succinylcholine, fasciculations and myoglobinaemia. ( Blanc, VF; Brisson, G; Vaillancourt, G, 1986) |
"N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi." | 5.62 | [Thromboembolisms due to recreational use of nitrous oxide]. ( de Metz, J; Fokkema, TMM; Kuipers, RS; Oomens, T; Riezebos, RK; van den Bogaard, B; van Nieuwenhuizen, RC, 2021) |
"A 50% nitrous oxide/oxygen (N(2)O/O(2)) premix is widely used to alleviate pain or anxiety during brief care procedures in various medical domains." | 5.12 | Safety of inhalation of a 50% nitrous oxide/oxygen premix: a prospective survey of 35 828 administrations. ( Gil, P; Hennequin, M; Onody, P, 2006) |
"02 mg X kg-1) on succinylcholine-induced fasciculations and myoglobinaemia was studied in 64 healthy children (ages two to nine years), anaesthetized with halothane, nitrous oxide and oxygen." | 3.67 | Succinylcholine, fasciculations and myoglobinaemia. ( Blanc, VF; Brisson, G; Vaillancourt, G, 1986) |
"Nitrous oxide anaesthesia is a particular risk." | 2.47 | Vitamin B12 deficiency and phenylketonuria. ( Walter, JH, 2011) |
"Nitrous oxide has been used as a component of general anesthesia for over 160 years and has contributed to countless apparently uneventful anesthetics in neurologically at-risk patients." | 2.46 | Is nitrous oxide use appropriate in neurosurgical and neurologically at-risk patients? ( Lanier, WL; Pasternak, JJ, 2010) |
"A vitamin B12 deficiency is unusual in pregnant women who consume a normal, varied diet." | 2.37 | Clinical chemistry of vitamin B12. ( Davis, RE, 1985) |
"All cases of neurological disorders related to nitrous oxide recreational use reported to the Hauts-de-France addictovigilance center between January 2019 and August 2020 were selected." | 1.72 | Myeloneuropathy induced by recreational nitrous oxide use with variable exposure levels. ( Bordet, R; Caous, AS; Carton, L; Deheul, S; Gautier, S; Karam, A; Kuchcinski, G; Largeau, B; Potey, C; Tard, C, 2022) |
"N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi." | 1.62 | [Thromboembolisms due to recreational use of nitrous oxide]. ( de Metz, J; Fokkema, TMM; Kuipers, RS; Oomens, T; Riezebos, RK; van den Bogaard, B; van Nieuwenhuizen, RC, 2021) |
"Nitrous oxide continues to be a valuable agent for the control of pain and anxiety." | 1.30 | Nitrous oxide in the dental office. ADA Council on Scientific Affairs; ADA Council on Dental Practice. ( , 1997) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 24 (41.38) | 18.7374 |
1990's | 13 (22.41) | 18.2507 |
2000's | 6 (10.34) | 29.6817 |
2010's | 7 (12.07) | 24.3611 |
2020's | 8 (13.79) | 2.80 |
Authors | Studies |
---|---|
Redmond, J | 1 |
Cruse, B | 1 |
Kiers, L | 1 |
Largeau, B | 1 |
Karam, A | 1 |
Potey, C | 1 |
Caous, AS | 1 |
Tard, C | 1 |
Carton, L | 1 |
Kuchcinski, G | 1 |
Gautier, S | 1 |
Deheul, S | 1 |
Bordet, R | 1 |
Fang, X | 1 |
Li, W | 1 |
Gao, H | 1 |
Ma, Y | 1 |
Dong, X | 1 |
Zheng, D | 1 |
Bethmont, A | 1 |
Harper, CE | 1 |
Chan, BS | 1 |
Dawson, AH | 1 |
McAnulty, J | 1 |
Brosset, C | 1 |
The Nguyen, H | 1 |
Do Van, T | 1 |
Giang Thuc, A | 1 |
Vallès, M | 1 |
Soler, D | 1 |
Albu, S | 1 |
Kumru, H | 1 |
Oomens, T | 1 |
Fokkema, TMM | 1 |
van den Bogaard, B | 1 |
de Metz, J | 1 |
van Nieuwenhuizen, RC | 1 |
Riezebos, RK | 1 |
Kuipers, RS | 1 |
Dang, XT | 1 |
Nguyen, TX | 1 |
Nguyen, TTH | 1 |
Ha, HT | 1 |
Sluyts, Y | 1 |
Pals, P | 1 |
Amir, R | 1 |
Vanherpe, P | 1 |
Egan, W | 1 |
Steinberg, E | 1 |
Rose, J | 1 |
de Vasconcellos, K | 1 |
Sneyd, JR | 1 |
Thompson, AG | 1 |
Leite, MI | 1 |
Lunn, MP | 1 |
Bennett, DL | 1 |
Pasternak, JJ | 3 |
McGregor, DG | 2 |
Lanier, WL | 3 |
Schroeder, DR | 2 |
Rusy, DA | 2 |
Hindman, B | 2 |
Clarke, W | 2 |
Torner, J | 2 |
Todd, MM | 2 |
Reynolds, F | 1 |
Walter, JH | 1 |
Weimann, J | 1 |
KIHLMAN, BA | 1 |
Onody, P | 1 |
Gil, P | 1 |
Hennequin, M | 1 |
Culley, DJ | 1 |
Crosby, G | 1 |
Hogan, K | 1 |
Samra, S | 1 |
Bayman, EO | 1 |
Weeks, J | 1 |
van der Westhuyzen, J | 3 |
Fernandes-Costa, F | 2 |
Metz, J | 4 |
Kanazawa, S | 1 |
Drivas, G | 1 |
Herbert, V | 1 |
Brodsky, JB | 1 |
Cohen, EN | 1 |
Brown, BW | 1 |
Wu, ML | 1 |
Whitcher, CE | 1 |
Michenfelder, JD | 1 |
Dyck, PJ | 1 |
Grina, LA | 1 |
Lambert, EH | 1 |
Calder, CS | 1 |
Oviatt, K | 1 |
Rehder, K | 1 |
Lund, BA | 1 |
Skau, KA | 1 |
King, M | 1 |
Coulter, C | 1 |
Boyle, RS | 1 |
Whitby, RM | 1 |
McMorrow, AM | 1 |
Adams, RJ | 1 |
Rubenstein, MN | 1 |
Hoffman, WE | 1 |
Thomas, C | 1 |
Albrecht, RF | 1 |
Werner, C | 1 |
Möllenberg, O | 1 |
Kochs, E | 1 |
Lucchini, R | 1 |
Placidi, D | 1 |
Toffoletto, F | 1 |
Alessio, L | 1 |
Howard, WR | 1 |
Mayall, M | 1 |
Iwata, K | 1 |
O'Keefe, GB | 1 |
Karanas, A | 1 |
Layzer, RB | 1 |
Eadie, MJ | 1 |
Malan, MD | 1 |
Crago, RR | 1 |
Stacy, CB | 1 |
Di Rocco, A | 1 |
Gould, RJ | 1 |
Chanarin, I | 1 |
Deacon, R | 1 |
Lumb, M | 1 |
Perry, J | 1 |
Melon, E | 1 |
Homs, JB | 1 |
Jastak, JT | 1 |
Gillman, MA | 2 |
Lichtigfeld, FJ | 1 |
Peduto, VA | 1 |
Napoleone, M | 1 |
Kano, Y | 1 |
Sakamoto, S | 1 |
Miura, Y | 1 |
Takaku, F | 1 |
Heyer, EJ | 1 |
Simpson, DM | 1 |
Bodis-Wollner, I | 1 |
Diamond, SP | 1 |
Davis, RE | 2 |
Icke, GC | 1 |
Weir, DG | 1 |
Keating, S | 1 |
Molloy, A | 1 |
McPartlin, J | 1 |
Kennedy, S | 1 |
Blanchflower, J | 1 |
Kennedy, DG | 1 |
Rice, D | 1 |
Scott, JM | 1 |
Blanc, VF | 1 |
Vaillancourt, G | 1 |
Brisson, G | 1 |
Schilling, RF | 1 |
Pope, WD | 1 |
Halsey, MJ | 1 |
Hammond, G | 1 |
Ward, CF | 1 |
McPherson, RW | 1 |
Mahla, M | 1 |
Johnson, R | 1 |
Traystman, RJ | 1 |
Murdoch, BD | 1 |
Fleming, JH | 1 |
Lines, JG | 1 |
Loder, RE | 1 |
Millar, RA | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Improving Labour Induction Analgesia: a Randomized Control Trial of Single Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour[NCT04011098] | Phase 1 | 5 participants (Actual) | Interventional | 2019-07-01 | Terminated (stopped due to Unable to meet recruitment numbers, lack of participation) | ||
Evaluation of the Effectiveness of Transcutaneous Electrical Nerve Stimulation During Labor. A Triple Blind Randomized Clinical Trial[NCT03137251] | 63 participants (Actual) | Interventional | 2017-05-01 | Completed | |||
Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement[NCT02696460] | 21 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
Longitudinal Assessment of Neurological Recovery in Patients Following Nitrous Oxide Abuse[NCT05714917] | 100 participants (Anticipated) | Observational | 2023-04-01 | Not yet recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
14 reviews available for nitrous oxide and Nervous System Disorders
Article | Year |
---|---|
Nitrous oxide: are we still in equipoise? A qualitative review of current controversies.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Intraoperative A | 2013 |
Is nitrous oxide use appropriate in neurosurgical and neurologically at-risk patients?
Topics: Anesthesia, General; Anesthetics, Inhalation; Blood Volume; Cerebrovascular Circulation; Electroence | 2010 |
Labour analgesia and the baby: good news is no news.
Topics: Acid-Base Equilibrium; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Apgar Score; Breast Feedin | 2011 |
Labour analgesia and the baby: good news is no news.
Topics: Acid-Base Equilibrium; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Apgar Score; Breast Feedin | 2011 |
Labour analgesia and the baby: good news is no news.
Topics: Acid-Base Equilibrium; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Apgar Score; Breast Feedin | 2011 |
Labour analgesia and the baby: good news is no news.
Topics: Acid-Base Equilibrium; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Apgar Score; Breast Feedin | 2011 |
Vitamin B12 deficiency and phenylketonuria.
Topics: Humans; Nervous System Diseases; Nitrous Oxide; Phenylketonurias; Vitamin B 12; Vitamin B 12 Deficie | 2011 |
Toxicity of nitrous oxide.
Topics: Animals; Bone Marrow; Folic Acid Deficiency; Humans; Methionine; Nervous System Diseases; Nitrous Ox | 2003 |
Nitrous oxide, vitamin B12 deficiency and the methyl folate trap.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Humans; L | 1982 |
Nitrous oxide in the dental environment: assessing the risk, reducing the exposure.
Topics: Air Pollution, Indoor; Anesthesia, Dental; Bone Marrow Diseases; Chemical and Drug Induced Liver Inj | 1997 |
Cobalamin deficiency and the pathogenesis of nervous system disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Disease Models, Animal; Humans; | 1992 |
Cobalamin and folate: recent developments.
Topics: Anemia, Megaloblastic; Female; Folic Acid; Humans; Methylation; Methylmalonic Acid; Nervous System D | 1992 |
Analgesic nitrous oxide in neuropsychiatry: past, present and future.
Topics: Humans; Mental Disorders; Nervous System Diseases; Nitrous Oxide | 1989 |
[Poisoning caused by chronic exposure to volatile anesthetics. Molecular mechanisms and risk anesthetics].
Topics: Air Pollutants, Occupational; Biodegradation, Environmental; Bromides; Chemical and Drug Induced Liv | 1989 |
Disorders of cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Isomerases; Anemia, Pernicious | 1985 |
Nitrous oxide, an opioid addictive agent. Review of the evidence.
Topics: Analgesia; Animals; Drug Tolerance; Humans; Locomotion; Nervous System Diseases; Nitrous Oxide; Opio | 1986 |
Clinical chemistry of vitamin B12.
Topics: Absorption; Adult; Alcoholism; Anemia, Pernicious; Ascorbic Acid; Autoantibodies; Biguanides; Biolog | 1985 |
2 trials available for nitrous oxide and Nervous System Disorders
Article | Year |
---|---|
Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery.
Topics: Adult; Balloon Occlusion; Cerebral Arteries; Female; Follow-Up Studies; Humans; Intracranial Aneurys | 2009 |
Safety of inhalation of a 50% nitrous oxide/oxygen premix: a prospective survey of 35 828 administrations.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Anesthetics, Combined; Anesthetics, Inhalation | 2006 |
42 other studies available for nitrous oxide and Nervous System Disorders
Article | Year |
---|---|
Nitrous oxide-induced neurological disorders: an increasing public health concern.
Topics: Adolescent; Humans; Nervous System Diseases; Nitrous Oxide; Public Health; Substance-Related Disorde | 2022 |
Myeloneuropathy induced by recreational nitrous oxide use with variable exposure levels.
Topics: Adolescent; Adult; Ataxia; Female; Humans; Male; Nervous System Diseases; Nitrous Oxide; Peripheral | 2022 |
Skin hyperpigmentation: a rare presenting symptom of nitrous oxide abuse.
Topics: China; Female; Humans; Hyperpigmentation; Illicit Drugs; Male; Nervous System Diseases; Nitrous Oxid | 2020 |
Increasing illicit use of nitrous oxide in presentations to NSW emergency departments.
Topics: Adolescent; Adult; Criminal Behavior; Emergency Service, Hospital; Female; Humans; Inhalant Abuse; M | 2019 |
[Neurological complications of nitrous oxide poisoning].
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Nervous System Diseases; Nitrous Oxide; Pos | 2020 |
[Neurological complications of nitrous oxide consumption. A case report].
Topics: Humans; Male; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency; Young Adult | 2021 |
[Thromboembolisms due to recreational use of nitrous oxide].
Topics: Female; Humans; Illicit Drugs; Male; Nervous System Diseases; Nitrous Oxide; Peripheral Nervous Syst | 2021 |
Nitrous Oxide-Induced Neuropathy among Recreational Users in Vietnam.
Topics: Adolescent; Adult; Humans; Nervous System Diseases; Nitrous Oxide; Peripheral Nervous System Disease | 2021 |
Recreational use of nitrous oxide may cause collateral neurological damage.
Topics: Adult; Female; Humans; Inhalation Exposure; Male; Nervous System Diseases; Nitrous Oxide; Recreation | 2021 |
Vitamin B
Topics: Emergency Service, Hospital; Female; Humans; Inhalant Abuse; Nervous System Diseases; Nitrous Oxide; | 2018 |
Whippits, nitrous oxide and the dangers of legal highs.
Topics: Adult; Analgesics, Non-Narcotic; Female; Humans; Male; Nervous System Diseases; Nitrous Oxide; Spina | 2015 |
The effect of oxygen, nitric oxide, and respiratory inhibitors on the production of chromosome aberration by x-rays.
Topics: Chromosome Aberrations; Chromosomes; Humans; Nervous System Diseases; Nitric Oxide; Nitrous Oxide; O | 1958 |
Nitrous oxide in neuroanesthesia: tried and true or toxin?
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Humans; Nervous System Diseases; Nitrous Oxide | 2008 |
Effect of nitrous oxide on neurologic and neuropsychological function after intracranial aneurysm surgery.
Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Hypothermia, Induced; Intracranial Aneurysm; Male; M | 2008 |
Cobalamin (vitamin B12) analogs are absent in plasma of fruit bats exposed to nitrous oxide.
Topics: Animals; Chiroptera; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 | 1982 |
Cobalamin inactivation by nitrous oxide produces severe neurological impairment in fruit bats : protection by methionine and aggravation by folates.
Topics: Animals; Chiroptera; Diet; Folic Acid; Formyltetrahydrofolates; Methionine; Nervous System Diseases; | 1982 |
Exposure to nitrous oxide and neurologic disease among dental professionals.
Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Dental Assistants; Dentists; Female; Humans; Male | 1981 |
Exposure to anesthetic gases and health problems in dental workers.
Topics: Abortion, Incomplete; Anesthesia, Inhalation; Dental Staff; Dentists; Female; Gases; Humans; Kidney | 1980 |
Nitrous oxide neurotoxicity studies in man and rat.
Topics: Adult; Animals; Dentists; Electromyography; Humans; Median Nerve; Middle Aged; Nerve Fibers; Nerve F | 1980 |
Neurotoxicity from overuse of nitrous oxide.
Topics: Adolescent; Humans; Male; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency | 1995 |
Combined system disease after nitrous oxide anesthesia: a case report.
Topics: Adult; Anesthesia; Female; Humans; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency | 1995 |
The effect of halothane and isoflurane on neurologic outcome following incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Animals; Brain Ischemia; Catecholamines; Fentanyl; Halothane; Isoflurane; Ma | 1993 |
Sevoflurane improves neurological outcome after incomplete cerebral ischaemia in rats.
Topics: Anesthetics; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Ethers; Fentanyl; Ischemic Atta | 1995 |
Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia.
Topics: Adult; Anesthesia; Female; Health Personnel; Humans; Hydrocortisone; Male; Nervous System Diseases; | 1996 |
Nitrous oxide in the dental office. ADA Council on Scientific Affairs; ADA Council on Dental Practice.
Topics: Air Pollution, Indoor; American Dental Association; Anesthesia, Dental; Dental Offices; Dentistry; E | 1997 |
Vitamin B12 deficiency and nitrous oxide.
Topics: Anesthesia, General; Humans; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency | 1999 |
Neurologic problems associated with chronic nitrous oxide abuse in a non-healthcare worker.
Topics: Humans; Inhalation Exposure; Male; Middle Aged; Nervous System Diseases; Nitrous Oxide; Substance-Re | 2001 |
Myeloneuropathy after prolonged exposure to nitrous oxide.
Topics: Adult; Anesthesia, Dental; Arm; Dental Technicians; Dentists; Erectile Dysfunction; Humans; Leg; Mal | 1978 |
Nervous laughter--or, hazards of laughing gas.
Topics: Humans; Nervous System Diseases; Nitrous Oxide; Occupational Diseases; Substance-Related Disorders | 1979 |
Anaesthetic considerations in idiopathic orthostatic hypotension and the Shy-Drager syndrome.
Topics: Adult; Anesthesia; Diazepam; Fecal Incontinence; Fentanyl; Humans; Hypotension, Orthostatic; Lidocai | 1979 |
Methionine in the treatment of nitrous-oxide-induced neuropathy and myeloneuropathy.
Topics: Adult; Anemia, Macrocytic; Female; Humans; Male; Methionine; Nervous System Diseases; Neuromuscular | 1992 |
[Nitrous oxide in neurosurgery].
Topics: Anesthesia, Inhalation; Animals; Brain; Cerebrovascular Circulation; Humans; Intracranial Pressure; | 1991 |
Nitrous oxide and its abuse.
Topics: Hematopoiesis; Humans; Nervous System Diseases; Nitrous Oxide; Students, Dental; Students, Medical; | 1991 |
Nitrous oxide: clinical and electrophysiologic investigation of neurologic complications.
Topics: Adult; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Humans; Male; Median Nerve; Nerv | 1986 |
Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment.
Topics: Animals; Brain; Chiroptera; Folic Acid; Liver; Methionine; Nervous System Diseases; Nitrous Oxide; S | 1987 |
Methylation deficiency causes vitamin B12-associated neuropathy in the pig.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Homocysteine; Methylation; Nervo | 1988 |
Succinylcholine, fasciculations and myoglobinaemia.
Topics: Age Factors; Anesthesia, General; Child; Child, Preschool; Drug Administration Schedule; Fasciculati | 1986 |
Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?
Topics: Adult; Erythrocyte Indices; Female; Hematocrit; Humans; Leukocyte Count; Middle Aged; Nervous System | 1986 |
Occupational Hazards of anaesthesia. A panel discussion.
Topics: Acquired Immunodeficiency Syndrome; Anesthesia; Anesthesiology; Environmental Pollutants; Female; He | 1985 |
Effects of enflurane, isoflurane, and nitrous oxide on somatosensory evoked potentials during fentanyl anesthesia.
Topics: Anesthesia, General; Arm; Blood Pressure; Body Temperature; Enflurane; Evoked Potentials, Somatosens | 1985 |
Pattern-reversal visual evoked potential in a case of nitrous oxide abuse and recovery.
Topics: Adult; Dentists; Diagnostic Errors; Evoked Potentials, Visual; Humans; Male; Multiple Sclerosis; Ner | 1985 |
Plasma cortisol responses during neurosurgical and abdominal operations.
Topics: Abdomen; Adrenal Glands; Adult; Aged; Anesthesia, General; Betamethasone; Brain Neoplasms; Craniotom | 1971 |