Page last updated: 2024-10-19

nitrous oxide and Myelopathy

nitrous oxide has been researched along with Myelopathy in 80 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Research Excerpts

ExcerptRelevanceReference
"Myelopathy with nitrous oxide presents as paralysis and numbness in limb extremities."7.91[Clinical features of long segmental myelopathy caused by nitrous oxide]. ( Dong, MR; Duan, XH; Hong, W; Jiao, JS; Jin, M; Liu, L; Liu, ZJ; Peng, DT; Sun, Q; Sun, SJ; Tian, ZH; Wang, L; Wang, RB; Wang, YY, 2019)
"Nitrous oxide myelopathy is rare in children."7.80Nitrous oxide myelopathy in a pediatric patient. ( Hu, MH; Huang, GS; Hung, PC; Wu, CT, 2014)
"The authors describe a patient who presented with acute tetraparesis and a proposed acute traumatic spinal cord injury that was the result of nitrous oxide myelopathy."7.78Nitrous oxide myelopathy posing as spinal cord injury. ( Dalyai, R; Flanders, AE; Ghobrial, GM; Harrop, J, 2012)
"We present a case of a patient who received nitrous oxide on two occasions within a period of 8 weeks and who subsequently developed a diffuse myelopathy, characterized by upper extremity paresis, lower extremity paraplegia and neurogenic bladder."7.73Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase. ( Lacassie, HJ; Mellado, P; Muir, HA; Nazar, C; Sandoval, P; Yonish, B, 2006)
"A 23 year old man presented with a severe posterior column myelopathy related to prolonged nitrous oxide abuse obtained from whipped cream bulbs."7.70Nitrous oxide myelopathy in an abuser of whipped cream bulbs. ( Butzkueven, H; King, JO, 2000)
"Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia."6.38Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. ( Flippo, TS; Holder, WD, 1993)
"Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused."5.46Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review. ( Hu, WL; Jiang, T; Wang, SK; Yuan, JL, 2017)
"In patients with postsurgical myelopathy, surgeons should evaluate B12 status and consider the possibility that nitrous oxide could cause a subclinical B12 deficiency to become overt, particularly in patients with malabsorptive GI comorbidities."4.98Subacute combined degeneration of the spinal cord following nitrous oxide anesthesia: A systematic review of cases. ( Alshafai, N; Cheng, J; Gimbel, D; Gunness, VRN; Hersey, D; Mejia Munne, JC; Nasser, R; Nouri, A; Patel, KK; Sciubba, D, 2018)
" Recognition of the toxic causes of myelopathy, including nitrous oxide exposure, heroin, radiation, various chemotherapeutic agents, liver disease, konzo, lathyrism, and zinc excess, is aided by understanding the typical clinical and imaging features associated with these agents."4.91Metabolic and toxic causes of myelopathy. ( Goodman, BP, 2015)
"Myelopathy with nitrous oxide presents as paralysis and numbness in limb extremities."3.91[Clinical features of long segmental myelopathy caused by nitrous oxide]. ( Dong, MR; Duan, XH; Hong, W; Jiao, JS; Jin, M; Liu, L; Liu, ZJ; Peng, DT; Sun, Q; Sun, SJ; Tian, ZH; Wang, L; Wang, RB; Wang, YY, 2019)
" However, persisting neurological signs despite adequate treatment lately led to diagnose subacute combined medullar degeneration due to abnormal cobalamin (vitamin B12) metabolism induced by repeated use of nitrous oxide during painful episodes of sickle-cell disease."3.80[Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration]. ( Cabral, D; Chaugny, C; Collin-Masson, H; De Beauchêne, M; Fagniez, O; Simon, J; Veyssier-Belot, C, 2014)
"Nitrous oxide myelopathy is rare in children."3.80Nitrous oxide myelopathy in a pediatric patient. ( Hu, MH; Huang, GS; Hung, PC; Wu, CT, 2014)
"The authors describe a patient who presented with acute tetraparesis and a proposed acute traumatic spinal cord injury that was the result of nitrous oxide myelopathy."3.78Nitrous oxide myelopathy posing as spinal cord injury. ( Dalyai, R; Flanders, AE; Ghobrial, GM; Harrop, J, 2012)
"We present a case of a patient who received nitrous oxide on two occasions within a period of 8 weeks and who subsequently developed a diffuse myelopathy, characterized by upper extremity paresis, lower extremity paraplegia and neurogenic bladder."3.73Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase. ( Lacassie, HJ; Mellado, P; Muir, HA; Nazar, C; Sandoval, P; Yonish, B, 2006)
"A 23 year old man presented with a severe posterior column myelopathy related to prolonged nitrous oxide abuse obtained from whipped cream bulbs."3.70Nitrous oxide myelopathy in an abuser of whipped cream bulbs. ( Butzkueven, H; King, JO, 2000)
"As vitamin B12 deficiency is caused by malabsorption in the gastrointestinal tract, oral supplementation is insufficient."2.41[Subacute combined degeneration of the spinal cord: easy diagnosis, effective treatment]. ( Franke, CL; Jongen, JC; Koehler, PJ, 2001)
"Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia."2.38Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. ( Flippo, TS; Holder, WD, 1993)
"Vitamin B12 deficiency was found in the first patient as well as signs of myelopathy on magnetic resonance imaging, and the second patient had acute liver injury."1.51[Acute neuropathy and liver injury following the abuse of nitrous oxide]. ( Bøgevig, S; Gullestrup, A; Jensen, RB; Nilsson, PM, 2019)
"Nitrous oxide is known to cause subacute degeneration of the spinal cord by inactivation of active vitamin B12."1.46[Nitrous oxide-induced polyneuropathy]. ( Beekman, R; Beerhorst, K; Bruijnes, JE; Conjaerts, SHP, 2017)
"Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused."1.46Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review. ( Hu, WL; Jiang, T; Wang, SK; Yuan, JL, 2017)
"Nitrous oxide is known to inactivate vitamin B12 via oxidation, which can precipitate a demyelinating myelopathy akin to the classical B12 deficiency syndrome, subacute combined degeneration of the spinal cord."1.43An unusual cause of falls in a young woman. ( Burn, D; Sleeman, I; Wiblin, L, 2016)
"A case of subacute combined degeneration (SCD) of the spinal cord manifesting as severe ataxia and urinary retention in a patient with a history of heavy nitrous oxide abuse and self-supplementation with cyanocobalamin is reported."1.42Subacute combined degeneration of the spinal cord in a patient abusing nitrous oxide and self-medicating with cyanocobalamin. ( Ambrose, TM; Neuburger, KJ; Oettinger, GR; Pugliese, RS; Slagle, EJ, 2015)
"Copper deficiency myelopathy (CDM) is an increasingly recognised mimic of subacute combined degeneration (SCD) of the cord due to cobalamin (vitamin B(12)) deficiency."1.35Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar? ( Jaiser, SR; Winston, GP, 2008)
"All presented with paresthesias, weakness, and Lhermitte's phenomena, and exhibited signs of sensorimotor polyneuropathy, ataxia, and arreflexia."1.28Reversible myeloneuropathy of nitrous oxide abuse: serial electrophysiological studies. ( Beresford, HR; Vishnubhakat, SM, 1991)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-19909 (11.25)18.7374
1990's11 (13.75)18.2507
2000's20 (25.00)29.6817
2010's26 (32.50)24.3611
2020's14 (17.50)2.80

Authors

AuthorsStudies
Le Borgne, P1
Colin, J1
Bilbault, P1
Andres, E1
Lorenzo-Villalba, N1
Wong, J1
Viyasar, T1
Layton, B1
Lauder, J1
Temple, C1
Horowitz, BZ1
Svensson, S1
Karbassi, A1
Johnsson, M1
Yang, SL1
Du, XQ1
Hu, YD1
Wang, EC1
Ye, Q1
Ng, GJ1
Chiew, YR1
Southwell, TG1
Diprose, WK1
Bigio, IKL1
Elliot, T1
Anderson, NE1
Yoon, JY1
Klein, JP1
Buttery, C1
Birns, J1
Gibson, J1
Jones, GD1
Mair, D1
Paris, A1
Zaloum, SA1
White, LM1
Dodd, KC1
Englezou, C1
Patel, F1
Abualnaja, S1
Lilleker, JB1
Gosal, D1
Hayton, T1
Liang, D1
Allroggen, H1
Pucci, M1
Keddie, S2
Noyce, AJ2
Demas, A1
Le Boisselier, R1
Simonnet, L1
De Menibus-Demas, L1
Langlois, V1
Cochin, JP1
Zhang, S1
Zhou, Z1
Wu, W1
Yu, Q1
Hong, M1
van den Hoven, C1
Lambrechts, S1
Reynders, T1
Padayachee, Y1
Richards, C1
Morgan, O1
Conjaerts, SHP1
Bruijnes, JE1
Beerhorst, K1
Beekman, R1
Yuan, JL1
Wang, SK1
Jiang, T1
Hu, WL1
Adams, A1
Kelso, ARC1
Turner, B1
Schmierer, K1
Gnanapavan, S1
Malaspina, A1
Giovannoni, G1
Basnett, I1
Patel, KK1
Mejia Munne, JC1
Gunness, VRN1
Hersey, D1
Alshafai, N1
Sciubba, D1
Nasser, R1
Gimbel, D1
Cheng, J1
Nouri, A1
Dong, X1
Ba, F1
Wang, R1
Zheng, D1
Williamson, J1
Huda, S1
Damodaran, D1
Wang, YY1
Wang, RB1
Hong, W1
Jiao, JS1
Peng, DT1
Liu, ZJ1
Tian, ZH1
Jin, M1
Dong, MR1
Duan, XH1
Liu, L1
Sun, Q1
Sun, SJ1
Wang, L1
Gullestrup, A1
Jensen, RB1
Bøgevig, S1
Nilsson, PM1
Francis, A1
Crossley, R1
Brady, S1
Chaugny, C1
Simon, J1
Collin-Masson, H1
De Beauchêne, M1
Cabral, D1
Fagniez, O1
Veyssier-Belot, C1
Rheinboldt, M1
Harper, D1
Parrish, D1
Francis, K1
Blase, J1
Hu, MH1
Huang, GS1
Wu, CT1
Hung, PC1
Safdieh, JE1
Goodman, BP1
Thompson, AG1
Leite, MI1
Lunn, MP1
Bennett, DL1
Pugliese, RS1
Slagle, EJ1
Oettinger, GR1
Neuburger, KJ1
Ambrose, TM1
Ernst, LD1
Brock, K1
Barraza, LH1
Davis, A1
Nirenberg, MJ1
Duque, MA1
Kresak, JL1
Falchook, A1
Harris, NS1
Massey, TH1
Pickersgill, TT1
J Peall, K1
Sleeman, I1
Wiblin, L1
Burn, D1
Meyers, LE1
Judge, BS1
Renard, D1
Dutray, A1
Remy, A1
Castelnovo, G1
Labauge, P1
Lin, RJ1
Chen, HF1
Chang, YC1
Su, JJ1
Probasco, JC1
Felling, RJ1
Carson, JT1
Dorsey, ER1
Niessen, TM1
Hsu, CK1
Chen, YQ1
Lung, VZ1
His, SC1
Lo, HC1
Shyu, HY1
Ghobrial, GM1
Dalyai, R1
Flanders, AE1
Harrop, J1
Sotirchos, ES1
Saidha, S1
Becker, D1
Senthilkumaran, S1
Balamurugan, N1
Menezes, RG1
Thirumalaikolundusubramanian, P1
Ng, J2
Frith, R2
O'Grady, G1
Pettit, T1
Doran, M1
Rassam, SS1
Jones, LM1
Underhill, S1
Diamond, AL1
Diamond, R1
Freedman, SM1
Thomas, FP1
Saif-Ur-Rehman Siddiqui, M1
Kymer, PJ1
Mayhew, JF1
Waters, MF1
Kang, GA1
Mazziotta, JC1
DeGiorgio, CM1
Lacassie, HJ1
Nazar, C1
Yonish, B1
Sandoval, P1
Muir, HA1
Mellado, P1
Singer, MA1
Lazaridis, C1
Nations, SP1
Wolfe, GI1
Wu, MS1
Hsu, YD1
Lin, JC1
Chen, SC1
Lee, JT1
Cartner, M1
Sinnott, M1
Silburn, P1
Winston, GP1
Jaiser, SR1
Scott, JM2
Dinn, JJ2
Wilson, P2
Weir, DG2
McCann, S1
Reed, B1
Hayden, PJ1
Hartemink, RJ1
Nicholson, GA1
Blanco, G1
Peters, HA1
Lunsford, JM1
Wynn, MH1
Kwan, WH1
Hadzic, A1
Glab, K1
Sanborn, KV1
Thys, DM1
Flippo, TS1
Holder, WD1
Rösener, M1
Dichgans, J1
Beltramello, A1
Puppini, G1
Cerini, R1
El-Dalati, G1
Manfredi, M1
Roncolato, G1
Idone, D1
De Togni, L1
Turazzini, M1
Pema, PJ1
Horak, HA1
Wyatt, RH1
Sesso, RM1
Iunes, Y1
Melo, AC1
Masson, C1
Butzkueven, H1
King, JO1
Vinciguerra, C1
Chazerain, P1
Olivero de Rubiana, JP1
Moulonguet, A1
Ziza, JM1
Deleu, D1
Hanssens, Y1
Louon, A1
Eichhorn, M1
Watson, M1
Wurst, F1
Jongen, JC1
Koehler, PJ1
Franke, CL1
van Geffen, GJ1
de Boer, HD1
Liem, T1
Ilniczky, S1
Jelencsik, I1
Kenéz, J1
Szirmai, I1
Layzer, RB1
Crosby, E1
Duffield, MS1
Phillips, JI1
Vieira-Makings, E1
Van der Westhuyzen, J1
Metz, J1
Vishnubhakat, SM1
Beresford, HR1
Holloway, KL1
Alberico, AM1
Shimizu, T1
Nishimura, Y1
Fujishima, Y1
Miyajima, H1
Honda, N1
Heyer, EJ1
Simpson, DM1
Bodis-Wollner, I1
Diamond, SP1
Whitby, JD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Longitudinal Assessment of Neurological Recovery in Patients Following Nitrous Oxide Abuse[NCT05714917]100 participants (Anticipated)Observational2023-04-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for nitrous oxide and Myelopathy

ArticleYear
Subacute combined degeneration of the spinal cord following nitrous oxide anesthesia: A systematic review of cases.
    Clinical neurology and neurosurgery, 2018, Volume: 173

    Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitrous Oxide; Spinal Cord; Sp

2018
Imaging appearance of myelopathy secondary to nitrous oxide abuse: a case report and review of the literature.
    The International journal of neuroscience, 2019, Volume: 129, Issue:3

    Topics: Adult; Cervical Cord; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Quadriplegia; Spinal

2019
Metabolic and toxic causes of myelopathy.
    Continuum (Minneapolis, Minn.), 2015, Volume: 21, Issue:1 Spinal C

    Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Humans; Metabolic Diseases; Nitrous Oxide;

2015
Subacute combined degeneration caused by nitrous oxide intoxication: case reports.
    Acta neurologica Taiwanica, 2011, Volume: 20, Issue:2

    Topics: Adolescent; Female; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Spinal Cord Diseases; S

2011
Severe neurologic deficit after nitrous oxide anesthesia.
    Anesthesiology, 1995, Volume: 83, Issue:4

    Topics: Anesthesia; Anesthetics, Inhalation; Female; Humans; Middle Aged; Nitrous Oxide; Spinal Cord Disease

1995
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.
    Archives of surgery (Chicago, Ill. : 1960), 1993, Volume: 128, Issue:12

    Topics: Anesthesia; Drug Interactions; Gait; Humans; Male; Middle Aged; Nitrous Oxide; Spinal Cord Diseases;

1993
[Postoperative combined medullary sclerosis revealing Biermer's disease: toxic effect of nitrous oxide].
    Revue neurologique, 2000, Volume: 156, Issue:6-7

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Abscess; Aged; Anemia, Pernicious; Anesth

2000
[Subacute combined degeneration of the spinal cord: easy diagnosis, effective treatment].
    Nederlands tijdschrift voor geneeskunde, 2001, Jun-30, Volume: 145, Issue:26

    Topics: Aged; Anemia, Megaloblastic; Anesthetics; Cervical Vertebrae; Female; Humans; Injections, Intramuscu

2001
[Subacute myeloneuropathy after abuse of nitrous oxide: an electron microscopic study on the peripheral nerve].
    Rinsho shinkeigaku = Clinical neurology, 1989, Volume: 29, Issue:9

    Topics: Adult; Demyelinating Diseases; Humans; Male; Microscopy, Electron; Nitrous Oxide; Peripheral Nervous

1989

Other Studies

71 other studies available for nitrous oxide and Myelopathy

ArticleYear
[Cervical myelopathy secondary to recreational nitrous oxide use: an emergent pathology].
    Medicina, 2021, Volume: 81, Issue:5

    Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord Diseases

2021
The dangers of recreational inhalation of nitrous oxide.
    British journal of hospital medicine (London, England : 2005), 2021, Dec-02, Volume: 82, Issue:12

    Topics: Adolescent; Humans; Nitrous Oxide; Spinal Cord Diseases; Subacute Combined Degeneration; Vitamin B 1

2021
Nitrous Oxide "Whippet" Induced Subacute Combined Degeneration of the Spinal Cord.
    The Journal of emergency medicine, 2022, Volume: 62, Issue:3

    Topics: Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; Subacute Combi

2022
[Cervical myelopathy due to nitrous oxide inhalation].
    Lakartidningen, 2022, 02-08, Volume: 119

    Topics: Administration, Inhalation; Adult; Hand; Humans; Male; Nitrous Oxide; Spinal Cord Diseases; Young Ad

2022
[Nitrous oxide abuse-induced myelopathy, peripheral neuropathy, and mental disorders:a case series].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2021, 12-20, Volume: 39, Issue:12

    Topics: Humans; Mental Disorders; Nitrous Oxide; Peripheral Nervous System Diseases; Research; Spinal Cord D

2021
Nitrous oxide and cervical myelopathy.
    Annals of the Academy of Medicine, Singapore, 2022, Volume: 51, Issue:5

    Topics: Cervical Vertebrae; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord Diseases; Substan

2022
Acute combined degeneration of the spinal cord following a recreational nitrous oxide binge.
    Practical neurology, 2022, Volume: 22, Issue:6

    Topics: Humans; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; Vitamin B 12 Deficiency

2022
Subacute Combined Degeneration from Nitrous Oxide Use.
    The New England journal of medicine, 2022, 09-01, Volume: 387, Issue:9

    Topics: Anesthetics, Inhalation; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord Diseases; Su

2022
Use of the Rehabilitation Treatment Specification System (RTSS) in the management of nitrous oxide (N
    BMJ case reports, 2023, Feb-07, Volume: 16, Issue:2

    Topics: Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord Diseases; Spinal Cord Injuries; Vitam

2023
Nitrous oxide-induced myeloneuropathy: a case series.
    Journal of neurology, neurosurgery, and psychiatry, 2023, Volume: 94, Issue:9

    Topics: Humans; Nitrous Oxide; Paresthesia; Spinal Cord Diseases; Substance-Related Disorders

2023
Another extensive nitrous oxide (N2O) myelopathy: The wood for the trees?
    Revue neurologique, 2020, Volume: 176, Issue:4

    Topics: Chronic Disease; Humans; Inhalation Exposure; Magnetic Resonance Imaging; Male; Nitrous Oxide; Pares

2020
Methylprednisolone combined vitamin supplementation reversed rapidly subacute combined degeneration of the spinal cord induced by the abuse of nitrous oxide.
    Acta neurologica Belgica, 2022, Volume: 122, Issue:5

    Topics: Dietary Supplements; Humans; Methylprednisolone; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; S

2022
Neuro-image: nitrous oxide-induced myelopathy due to vitamin B
    Acta neurologica Belgica, 2022, Volume: 122, Issue:1

    Topics: Humans; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins

2022
Inhaled nitrous oxide-induced functional B
    BMJ case reports, 2021, Mar-15, Volume: 14, Issue:3

    Topics: Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Oxides; Spinal Cord Diseases; Subacute Comb

2021
[Nitrous oxide-induced polyneuropathy].
    Nederlands tijdschrift voor geneeskunde, 2017, Volume: 161

    Topics: Adolescent; Female; Humans; Male; Nitrous Oxide; Polyneuropathies; Spinal Cord Diseases; Vitamin B 1

2017
Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review.
    BMC neurology, 2017, Dec-28, Volume: 17, Issue:1

    Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord Diseases; Subacute Com

2017
No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation.
    Journal of neurology, 2018, Volume: 265, Issue:5

    Topics: Adolescent; Adult; Ataxia; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Male

2018
Nitrous oxide myelopathy with functional vitamin B
    BMJ case reports, 2019, Feb-13, Volume: 12, Issue:2

    Topics: Adolescent; Humans; Illicit Drugs; Male; Nitrous Oxide; Spinal Cord Diseases; Treatment Outcome; Uni

2019
[Clinical features of long segmental myelopathy caused by nitrous oxide].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2019, Apr-18, Volume: 51, Issue:2

    Topics: Adolescent; China; Female; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Retrospective St

2019
[Acute neuropathy and liver injury following the abuse of nitrous oxide].
    Ugeskrift for laeger, 2019, May-13, Volume: 181, Issue:20

    Topics: Denmark; Humans; Liver; Male; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12 Deficiency

2019
Subacute progressive sensorimotor symptoms.
    BMJ (Clinical research ed.), 2019, Jun-11, Volume: 365

    Topics: Adult; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseas

2019
[Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration].
    La Revue de medecine interne, 2014, Volume: 35, Issue:5

    Topics: Analgesics, Non-Narcotic; Anemia, Sickle Cell; Drug-Related Side Effects and Adverse Reactions; Huma

2014
Nitrous oxide induced myeloneuropathy: a case report.
    Emergency radiology, 2014, Volume: 21, Issue:1

    Topics: Adult; Contrast Media; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Male; Nitrous Ox

2014
Nitrous oxide myelopathy in a pediatric patient.
    Pediatric emergency care, 2014, Volume: 30, Issue:4

    Topics: Administration, Inhalation; Adolescent; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Diagnosis

2014
Patient management problem.
    Continuum (Minneapolis, Minn.), 2014, Volume: 20, Issue:3 Neurolog

    Topics: Adenocarcinoma; Aged; Alcoholism; Anesthetics, Inhalation; Bariatric Surgery; Diabetes Mellitus, Typ

2014
Whippits, nitrous oxide and the dangers of legal highs.
    Practical neurology, 2015, Volume: 15, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Female; Humans; Male; Nervous System Diseases; Nitrous Oxide; Spina

2015
Subacute combined degeneration of the spinal cord in a patient abusing nitrous oxide and self-medicating with cyanocobalamin.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Jun-01, Volume: 72, Issue:11

    Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Self Medication; Spinal Cord Disea

2015
Longitudinally Extensive Nitrous Oxide Myelopathy With Novel Radiographic Features.
    JAMA neurology, 2015, Volume: 72, Issue:11

    Topics: Adult; Humans; Illicit Drugs; Male; Nitrous Oxide; Spinal Cord Diseases

2015
Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report.
    Laboratory medicine, 2015,Fall, Volume: 46, Issue:4

    Topics: Adult; Demyelinating Diseases; Female; Humans; Methylmalonic Acid; Nitrous Oxide; Paresthesia; Spina

2015
Nitrous oxide misuse and vitamin B12 deficiency.
    BMJ case reports, 2016, May-31, Volume: 2016

    Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Humans; Magnetic Re

2016
An unusual cause of falls in a young woman.
    The journal of the Royal College of Physicians of Edinburgh, 2016, Volume: 46, Issue:3

    Topics: Accidental Falls; Adult; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Chronic Pain; Demyelinat

2016
Myeloneuropathy in a dentist.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:10

    Topics: Anesthetics, Inhalation; Dentists; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitrous Ox

2008
Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2009, Volume: 30, Issue:1

    Topics: Afferent Pathways; Anesthetics, Inhalation; Causality; Disease Progression; Gait Ataxia; Humans; Iat

2009
Teaching NeuroImages: myelopathy due to B₁₂ deficiency in long-term colchicine treatment and nitrous oxide misuse.
    Neurology, 2011, Aug-30, Volume: 77, Issue:9

    Topics: Adult; Colchicine; Humans; Male; Nitrous Oxide; Spinal Cord Diseases; Substance-Related Disorders; V

2011
Myelopathy and polyneuropathy caused by nitrous oxide toxicity: a case report.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:6

    Topics: Emergency Service, Hospital; Humans; Inhalant Abuse; Male; Nitrous Oxide; Polyneuropathies; Spinal C

2012
Nitrous oxide myelopathy posing as spinal cord injury.
    Journal of neurosurgery. Spine, 2012, Volume: 16, Issue:5

    Topics: Anesthetics, Inhalation; Diagnosis, Differential; Humans; Male; Nitrous Oxide; Spinal Cord Diseases;

2012
Neurological picture. Nitrous oxide-induced myelopathy with inverted V-sign on spinal MRI.
    Journal of neurology, neurosurgery, and psychiatry, 2012, Volume: 83, Issue:9

    Topics: Adult; Cervical Vertebrae; Humans; Inhalant Abuse; Magnetic Resonance Imaging; Male; Nitrous Oxide;

2012
Nitrous oxide toxicity: technical and therapeutic aspects.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:2

    Topics: Humans; Inhalant Abuse; Male; Nitrous Oxide; Polyneuropathies; Spinal Cord Diseases

2013
Nanging.
    Lancet (London, England), 2002, Aug-03, Volume: 360, Issue:9330

    Topics: Administration, Inhalation; Adult; Analgesics, Non-Narcotic; Humans; Male; Nitrous Oxide; Spinal Cor

2002
Nitrous oxide use in first-year students at Auckland University.
    Lancet (London, England), 2003, Apr-19, Volume: 361, Issue:9366

    Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Health Surveys; Humans; Illicit Drugs; Incidence

2003
Toxicity after intermittent inhalation of nitrous oxide for analgesia.
    BMJ (Clinical research ed.), 2004, Jun-05, Volume: 328, Issue:7452

    Topics: Adult; Analgesia, Patient-Controlled; Anesthetics, Combined; Anesthetics, Inhalation; Drug Interacti

2004
"Whippets"-induced cobalamin deficiency manifesting as cervical myelopathy.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2004, Volume: 14, Issue:3

    Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; S

2004
Escobar syndrome.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:9

    Topics: Abnormalities, Multiple; Anesthetics, Inhalation; Child, Preschool; Craniofacial Abnormalities; Fema

2004
Nitrous oxide inhalation as a cause of cervical myelopathy.
    Acta neurologica Scandinavica, 2005, Volume: 112, Issue:4

    Topics: Administration, Inhalation; Adult; Cervical Vertebrae; Humans; Magnetic Resonance Imaging; Male; Nit

2005
Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase.
    British journal of anaesthesia, 2006, Volume: 96, Issue:2

    Topics: Anesthetics, Inhalation; Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia

2006
Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review.
    Muscle & nerve, 2008, Volume: 37, Issue:1

    Topics: Adult; Anemia, Pernicious; Anesthetics, Inhalation; Female; Humans; Leg; Magnetic Resonance Imaging;

2008
Spinal myoclonus in subacute combined degeneration caused by nitrous oxide intoxication.
    Acta neurologica Taiwanica, 2007, Volume: 16, Issue:2

    Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Myoclonus; Nitrous Oxide; Spinal Cord Diseases; S

2007
Paralysis caused by "nagging".
    The Medical journal of Australia, 2007, Sep-17, Volume: 187, Issue:6

    Topics: Adult; Female; Humans; Malnutrition; Nitrous Oxide; Paralysis; Spinal Cord Diseases; Substance Abuse

2007
Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar?
    Medical hypotheses, 2008, Volume: 71, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Copper; Electron Transport Complex IV; Hu

2008
Pathogenesis of subacute combined degeneration: a result of methyl group deficiency.
    Lancet (London, England), 1981, Aug-15, Volume: 2, Issue:8242

    Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Humans; Macaca fascicularis; Methionine; Ni

1981
Methyl group deficiency in nerve tissue: a hypothesis to explain the lesion of subacute combined degeneration.
    Irish journal of medical science, 1980, Volume: 149, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cercopithecus; Disease Models, A

1980
Myeloneuropathy due to nitrous oxide.
    Burns, including thermal injury, 1983, Volume: 9, Issue:4

    Topics: Adult; Burns; Humans; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Spinal Cord Diseases

1983
Myeloneuropathy and macrocytosis associated with nitrous oxide abuse.
    Archives of neurology, 1983, Volume: 40, Issue:7

    Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Humans; Male; Nitrous Oxide; Peripheral Nervous Sy

1983
Nitrous oxide-induced myeloneuropathy.
    The Journal of foot surgery, 1983,Fall, Volume: 22, Issue:3

    Topics: Adult; Humans; Hypesthesia; Leg; Male; Muscle Hypotonia; Muscles; Nitrous Oxide; Paresthesia; Periph

1983
Severe combined degeneration of the spinal cord after nitrous oxide anaesthesia in a vegetarian.
    Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 60, Issue:3

    Topics: Anesthetics, Inhalation; Diet, Vegetarian; Female; Humans; Middle Aged; Nitrous Oxide; Spinal Cord D

1996
Subacute combined degeneration of the spinal cord after nitrous oxide anaesthesia: role of magnetic resonance imaging.
    Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 64, Issue:4

    Topics: Aged; Anesthetics, Inhalation; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging;

1998
Myelopathy caused by nitrous oxide toxicity.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:5

    Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Neck; Nitrous Oxide; Spinal Cord; Spinal Cord Disea

1998
Myeloneuropathy following nitrous oxide anesthaesia in a patient with macrocytic anaemia.
    Neuroradiology, 1999, Volume: 41, Issue:8

    Topics: Anemia, Macrocytic; Anesthetics, Inhalation; Demyelinating Diseases; Female; Humans; Magnetic Resona

1999
[Combined sclerosis of the spinal cord "revisited"].
    Presse medicale (Paris, France : 1983), 1999, Nov-27, Volume: 28, Issue:37

    Topics: Anesthetics, Inhalation; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Risk Factors; Sclerosis;

1999
Nitrous oxide myelopathy in an abuser of whipped cream bulbs.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2000, Volume: 7, Issue:1

    Topics: Adult; Cervical Vertebrae; Humans; Male; Methionine; Nitrous Oxide; Spinal Cord Diseases; Substance-

2000
Nitrous oxide-induced cobalamin deficiency.
    Archives of neurology, 2001, Volume: 58, Issue:1

    Topics: Folic Acid Deficiency; Humans; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12 Deficiency

2001
[Polyneuropathy and myelopathy in N2O abuse within the scope of multiple drug abuse].
    Psychiatrische Praxis, 2001, Volume: 28, Issue:4

    Topics: Adult; Humans; Illicit Drugs; Male; Neurologic Examination; Nitrous Oxide; Polyneuropathies; Spinal

2001
[Subacute combined degeneration of the spinal cord due to vitamin B12 deficiency: easy diagnosis, effective therapy].
    Nederlands tijdschrift voor geneeskunde, 2001, Nov-10, Volume: 145, Issue:45

    Topics: Anemia, Megaloblastic; Anesthetics; Humans; Malabsorption Syndromes; Mass Screening; Nitrous Oxide;

2001
MR findings in subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia--two cases.
    European journal of neurology, 2002, Volume: 9, Issue:1

    Topics: Anesthetics, Inhalation; Cholecystectomy; Electromyography; Humans; Magnetic Resonance Imaging; Male

2002
Myeloneuropathy after prolonged exposure to nitrous oxide.
    Lancet (London, England), 1978, Dec-09, Volume: 2, Issue:8102

    Topics: Adult; Anesthesia, Dental; Arm; Dental Technicians; Dentists; Erectile Dysfunction; Humans; Leg; Mal

1978
Does propofol-nitrous oxide anaesthesia provide autonomic hyperreflexia (AH) prophylaxis in susceptible patients?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:5 Pt 1

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Autonomic Nervous System; Blood Pressure; Di

1992
Demyelinisation in the spinal cord of vitamin B12 deficient fruit bats.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1990, Volume: 96, Issue:2

    Topics: Animals; Chiroptera; Demyelinating Diseases; Microscopy, Electron; Nitrous Oxide; Spinal Cord Diseas

1990
Reversible myeloneuropathy of nitrous oxide abuse: serial electrophysiological studies.
    Muscle & nerve, 1991, Volume: 14, Issue:1

    Topics: Adult; Ataxia; Electromyography; Electrophysiology; Female; Humans; Male; Neural Conduction; Nitrous

1991
Postoperative myeloneuropathy: a preventable complication in patients with B12 deficiency.
    Journal of neurosurgery, 1990, Volume: 72, Issue:5

    Topics: Female; Humans; Intervertebral Disc Displacement; Middle Aged; Nitrous Oxide; Peripheral Nervous Sys

1990
Nitrous oxide: clinical and electrophysiologic investigation of neurologic complications.
    Neurology, 1986, Volume: 36, Issue:12

    Topics: Adult; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Humans; Male; Median Nerve; Nerv

1986
General anaesthesia for myelography.
    Anaesthesia, 1971, Volume: 26, Issue:1

    Topics: Anesthesia, General; Barbiturates; Blood Pressure Determination; Child; Child, Preschool; Halothane;

1971