nitrous oxide has been researched along with Methemoglobinemia in 6 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This communication reports a case of acute toxic methemoglobinemia associated with hypoxia and general motor seizures following dental anesthesia using nitrous oxide and prilocaine hydrochloride." | 3.66 | Acute toxic methemoglobinemia following dental analgesia. ( Ludwig, SC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trapp, L | 1 |
| Will, J | 1 |
| Clutton-Brock, J | 1 |
| Ludwig, SC | 1 |
| Misiewicz, A | 1 |
| Shira, RB | 1 |
| Greenfield, W | 1 |
| Karpinski, JF | 1 |
| Gabel, RA | 1 |
| Bunn, HF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
1 review available for nitrous oxide and Methemoglobinemia
| Article | Year |
|---|---|
Acquired methemoglobinemia revisited.
Topics: Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Local; Benzocaine; Enzyme Inhibitors; Hemogl | 2010 |
5 other studies available for nitrous oxide and Methemoglobinemia
| Article | Year |
|---|---|
Two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anaesthesia.
Topics: Adult; Anesthesia, Inhalation; Blood Chemical Analysis; Diagnosis, Differential; Female; Humans; Met | 1967 |
Acute toxic methemoglobinemia following dental analgesia.
Topics: Acute Disease; Anesthesia, Dental; Child, Preschool; Humans; Male; Methemoglobinemia; Nitrous Oxide; | 1981 |
[The transferrin and the ceruloplasmin levels in the blood serum of subjects chronically exposed to nitric oxides (author's transl)].
Topics: Air Pollutants; Air Pollutants, Occupational; Ceruloplasmin; Humans; Male; Methemoglobinemia; Nitrou | 1980 |
Citanest Forte--its use in oral surgery.
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; Female; Humans; Male; Met | 1975 |
Hereditary methemoglobinemia as a cause of cyanosis during anesthesia.
Topics: Anesthesia, Inhalation; Ascorbic Acid; Blood Gas Analysis; Cyanosis; Female; Hemoglobins; Humans; Me | 1974 |