Page last updated: 2024-10-19

nitrous oxide and Laryngismus

nitrous oxide has been researched along with Laryngismus in 23 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Laryngismus: A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.

Research Excerpts

ExcerptRelevanceReference
"Intranasal dexmedetomidine and midazolam are equally effective in decreasing anxiety upon separation from parents; however, midazolam is superior in providing satisfactory conditions during mask induction."5.16Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia. ( Akin, A; Aksu, R; Altuntas, R; Bayram, A; Boyaci, A; Esmaoglu, A; Tosun, Z, 2012)
"The frequencies of laryngospasm and coughing of any severity after desflurane were greater than those after isoflurane (13% vs 5% and 26% vs 14%, respectively) (P < 0."2.75Airway responses to desflurane during maintenance of anesthesia and recovery in children with laryngeal mask airways. ( Betts, E; Deutsch, J; Ehlers, M; Hammer, GB; Khalil, SN; Lerman, J; Trillo, R; Verghese, S, 2010)
"Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction."2.69Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane. ( Lee, TL; Pua, HL; Ti, LK, 1998)
"The presence of gagging, coughing, laryngospasm and movement was noted and graded."2.67Patient response to laryngeal mask insertion after induction of anaesthesia with propofol or thiopentone. ( Carey, M; Kirby, F; Power, M; Scanlon, P, 1993)
"Desflurane was used for maintenance of anesthesia."1.39Minimum alveolar concentration of desflurane with caudal analgesia for laryngeal mask airway removal in anesthetized children. ( Ghai, B; Makkar, JK; Wig, J, 2013)
"Following the scout scan, severe laryngospasm developed."1.37Computed tomography changes of alveoli and airway collapse after laryngospasm. ( Erb, TO; Johnson, J; Keating, M; von Ungern-Sternberg, BS, 2011)
" We characterize the fasting status of patients receiving procedural sedation and analgesia in a pediatric ED and assess the relationship between fasting status and adverse events."1.32Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. ( Agrawal, D; Gupta, R; Krauss, B; Manzi, SF, 2003)
"Moderate-to-severe laryngospasm (49%) and moderate-to-severe coughing (58%) occurred frequently during induction of anesthesia with desflurane; the incidence of these was not altered by premedication."1.28Induction and maintenance characteristics of anesthesia with desflurane and nitrous oxide in infants and children. ( Coté, CJ; Davis, PJ; Dinner, M; Fisher, DM; Hannallah, RS; Liu, LM; McGill, WA; Sarner, J; Welborn, LG; Zwass, MS, 1992)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's6 (26.09)18.2507
2000's4 (17.39)29.6817
2010's8 (34.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Makkar, JK2
Ghai, B2
Wig, J2
Babl, FE1
Grindlay, J1
Barrett, MJ1
Smits, GJP1
Thijssen, WAMH1
Umesh, G1
Jasvinder, K1
Ramkumar, V1
D'Eramo, EM3
Bontempi, WJ1
Howard, JB1
Lerman, J1
Hammer, GB1
Verghese, S1
Ehlers, M1
Khalil, SN1
Betts, E1
Trillo, R1
Deutsch, J1
Keating, M1
Johnson, J1
Erb, TO1
von Ungern-Sternberg, BS1
Bhardwaj, N1
Akin, A1
Bayram, A1
Esmaoglu, A1
Tosun, Z1
Aksu, R1
Altuntas, R1
Boyaci, A1
Agrawal, D1
Manzi, SF1
Gupta, R1
Krauss, B1
Galante, D1
Pellico, G1
Federico, A1
Schiraldi, R1
Matella, M1
Milillo, R1
Dambrosio, M1
Cinnella, G1
Scanlon, P1
Carey, M1
Power, M1
Kirby, F1
Harling, DW1
Harrison, DA1
Dorman, T1
Barker, I1
Ti, LK1
Pua, HL1
Lee, TL1
Lanning, CF1
Harmel, MH1
Cibils, LA1
Zwass, MS1
Fisher, DM1
Welborn, LG1
Coté, CJ1
Davis, PJ1
Dinner, M1
Hannallah, RS1
Liu, LM1
Sarner, J1
McGill, WA1
Jeppesen, K1
Carugati, G1
Fessl-Alemany, E1
Stöcker, L1
Taube, HD1
Wessing, A1
Noble, FP1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nebulized Midazolam, Dexmedetomidine, and Their Combination in Sedation of Preschoolers Undergoing Dental Treatment: A Randomized Clinical Trial[NCT03827408]Phase 272 participants (Actual)Interventional2017-11-27Completed
Effectiveness and Pulmonary Complications of Peri-Operative Laryngeal Mask Airway Used in Elderly Patients(POLMA-EP Trial): a Multi-center Randomized Controlled Clinical Trial[NCT02240901]2,900 participants (Actual)Interventional2016-08-03Completed
Comparing the Efficacy Between Desflurane and Sevoflurane in Miantainance of Spontaneous General Anaesthesia Using Ambu Aura Gain in Paediatrics Patients[NCT04771962]Phase 1/Phase 280 participants (Actual)Interventional2020-01-01Completed
Effect of Head Position on Minimum Alveolar Concentration of Endotracheal Intubation(MACEI)of Sevoflurane in Children With Obstructive Airway[NCT03522402]38 participants (Anticipated)Interventional2018-01-01Enrolling by invitation
Evaluating Stress Response and Anxiety Score in Paediatric Patients Sedated With Intranasal Dexmedetomidine[NCT04526652]Phase 260 participants (Actual)Interventional2020-12-01Completed
Comparing Intranasal Dexmedetomidine With Oral Midazolam as Premedication for Older Children Undergoing General Anesthesia for Dental Rehabilitation[NCT02250703]Phase 375 participants (Actual)Interventional2014-09-30Completed
Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638]240 participants (Anticipated)Interventional2015-10-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

University of Michigan Sedation Scale

"Level of sedation at separation from parents and at the time of mask induction will be measured on a scale of 0 to 4 (University of Michigan Sedation Scale)~University of Michigan Sedation Scale:~0 -Awake/Alert~1 -Minimally Sedated: Tired/sleepy, appropriate response to verbal conversation and/or sounds.~2- Moderately Sedated: Somnolent/sleeping, easily aroused with light tactile stimulation.~3 - Deeply Sedated: Deep sleep, arousable only with significant physical stimulation.~4 - Unarousable~Moderately and Deeply sedated: Satisfactory Awake, minimally sedate, unarousable: Unsatisfactory" (NCT02250703)
Timeframe: Day 0:Just before the patient will be brought to the operating room

,
InterventionParticipants (Count of Participants)
Satisfactory sedation on separation from parentsUnsatisfactory sedation on separation from parentsSatisfactory sedation on transfer to OR tableUnsatisfactory sedation on transfer to OR table
Dexmedetomidine25112214
Midazolam15221225

Reviews

1 review available for nitrous oxide and Laryngismus

ArticleYear
Ketamine anesthesia.
    Annual review of medicine, 1975, Volume: 26

    Topics: Anesthesia, General; Animals; Blood Pressure; Bronchial Spasm; Central Nervous System; Central Venou

1975

Trials

5 trials available for nitrous oxide and Laryngismus

ArticleYear
Airway responses to desflurane during maintenance of anesthesia and recovery in children with laryngeal mask airways.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:6

    Topics: Adolescent; Age Factors; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Inhalation; A

2010
Airway responses to desflurane during maintenance of anesthesia and recovery in children with laryngeal mask airways.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:6

    Topics: Adolescent; Age Factors; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Inhalation; A

2010
Airway responses to desflurane during maintenance of anesthesia and recovery in children with laryngeal mask airways.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:6

    Topics: Adolescent; Age Factors; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Inhalation; A

2010
Airway responses to desflurane during maintenance of anesthesia and recovery in children with laryngeal mask airways.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:6

    Topics: Adolescent; Age Factors; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Inhalation; A

2010
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:9

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine;

2012
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:9

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine;

2012
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:9

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine;

2012
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:9

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine;

2012
Patient response to laryngeal mask insertion after induction of anaesthesia with propofol or thiopentone.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:9

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Cough; Extremities; Female; Gagging; Head; H

1993
A comparison of thiopentone-isoflurane anaesthesia vs propofol infusion in children having repeat minor haematological procedures.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:1

    Topics: Acute Disease; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Biopsy, Nee

1997
Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:10

    Topics: Adolescent; Adult; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Coug

1998

Other Studies

17 other studies available for nitrous oxide and Laryngismus

ArticleYear
Minimum alveolar concentration of desflurane with caudal analgesia for laryngeal mask airway removal in anesthetized children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:11

    Topics: Airway Extubation; Analgesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Breath Holding; Child

2013
Laryngospasm With Apparent Aspiration During Sedation With Nitrous Oxide.
    Annals of emergency medicine, 2015, Volume: 66, Issue:5

    Topics: Adolescent; Conscious Sedation; Emergency Service, Hospital; Humans; Hypnotics and Sedatives; Laryng

2015
Laryngospasm With Apparent Aspiration During Sedation With Nitrous Oxide.
    Annals of emergency medicine, 2016, Volume: 67, Issue:6

    Topics: Anesthesia; Conscious Sedation; Humans; Laryngismus; Nitrous Oxide

2016
Guideline for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures: Update 2016.
    Pediatric dentistry, 2016, Oct-15, Volume: 38, Issue:5

    Topics: Airway Management; Airway Obstruction; Anesthesia, General; Anesthetics, Local; Apnea; Capnography;

2016
Management of laryngospasm - our concerns and suggestions.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:10

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Humans; Infusions, Intravenous; Laryngismus; Nitrog

2008
Anesthesia morbidity and mortality experience among Massachusetts oral and maxillofacial surgeons.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2008, Volume: 66, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, Gene

2008
Computed tomography changes of alveoli and airway collapse after laryngospasm.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:5

    Topics: Anesthesia, General; Anesthetics, Inhalation; Female; Humans; Infant; Laryngismus; Lung; Methyl Ethe

2011
Minimum alveolar concentration of desflurane with fentanyl for laryngeal mask airway removal in anesthetized children.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:4

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Cou

2012
Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.
    Annals of emergency medicine, 2003, Volume: 42, Issue:5

    Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Combined; Child; Child, Preschool; Chloral Hydrate; C

2003
Postextubation adverse events in children undergoing general anesthesia.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:2

    Topics: Air Pressure; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Croup; Equip

2007
Mortality and morbidity with outpatient anesthesia: the Massachusetts experience.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1999, Volume: 57, Issue:5

    Topics: Aged; Ambulatory Care; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, General; Anesthesia, Loca

1999
Anesthesia for coelioscopy.
    Acta Europaea fertilitatis, 1975, Volume: 6, Issue:3

    Topics: Abdomen; Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Local; Arrhythmias, Ca

1975
Induction and maintenance characteristics of anesthesia with desflurane and nitrous oxide in infants and children.
    Anesthesiology, 1992, Volume: 76, Issue:3

    Topics: Anesthesia, Inhalation; Atropine; Child; Child, Preschool; Cough; Desflurane; Diazepam; Halothane; H

1992
Morbidity and mortality with outpatient anesthesia: the Massachusetts experience.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1992, Volume: 50, Issue:7

    Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intraveno

1992
[General anesthesia for outpatient dental treatment of children].
    Tandlaegebladet, 1973, Volume: 77, Issue:6

    Topics: Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Blood Pressure; Child; Child, Preschool; D

1973
[General anaesthesia in ophthalmic surgery. 5 year report from the eye hospital Essen].
    Klinische Monatsblatter fur Augenheilkunde, 1973, Volume: 162, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anest

1973
Office experience with nitrous oxide-halothane anesthesia.
    Journal of oral surgery (American Dental Association : 1965), 1967, Volume: 25, Issue:5

    Topics: Anesthesia, Dental; Anesthesia, General; Atropine; Barbiturates; Blood Pressure Determination; Costs

1967