nitrous oxide has been researched along with Hypothermia, Accidental in 31 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An initial administration of 60% nitrous oxide (N(2)O) evokes hypothermia in rats and if the administration continues for more than 1-2h, acute tolerance typically develops such that the initial reduction in core temperature (Tc) reverses and Tc recovers toward control values." | 7.77 | Nitrous oxide causes a regulated hypothermia: rats select a cooler ambient temperature while becoming hypothermic. ( Kaiyala, KJ; Ramsay, DS; Seaman, J, 2011) |
| "On average, the hypothermia exhibited by rats receiving 60% nitrous oxide (N2O) eventually abates despite the continued inhalation of the drug (i." | 7.71 | Reliability of individual differences in initial sensitivity and acute tolerance to nitrous oxide hypothermia. ( Coldwell, SE; Kaiyala, KJ; Leroux, BG; Prall, CW; Ramsay, DS; Watson, CH; Woods, SC, 2001) |
| "Although inhalation of nitrous oxide (N2O) causes hypothermia in rats, there is a paucity of information as to whether tolerance develops to this effect." | 7.70 | Nitrous oxide-induced hypothermia in the rat: acute and chronic tolerance. ( Leroux, BG; Omachi, K; Prall, CW; Ramsay, DS; Seeley, RJ; Woods, SC, 1999) |
| "In this effectiveness trial, inhalation inductions with sevoflurane or with prophylactic phenylephrine bolus prior to propofol induction reduced the magnitude of redistribution hypothermia by an average of 0." | 5.30 | Induction techniques that reduce redistribution hypothermia: a prospective, randomized, controlled, single blind effectiveness study. ( Braitman, LE; Hunt, LH; Roth, JV, 2019) |
| "Initial administration of ≥60% nitrous oxide (N2O) to rats evokes hypothermia, but after repeated administrations the gas instead evokes hyperthermia." | 3.88 | Concentration-related metabolic rate and behavioral thermoregulatory adaptations to serial administrations of nitrous oxide in rats. ( Kaiyala, KJ; Ramsay, DS, 2018) |
| "Initial administration of ≥60% nitrous oxide (N2O) to rats promotes hypothermia primarily by increasing whole-body heat loss." | 3.83 | Brown adipose tissue thermogenesis does not explain the intra-administration hyperthermic sign-reversal induced by serial administrations of 60% nitrous oxide to rats. ( Al-Noori, S; Cimpan, A; Kaiyala, KJ; Maltzer, Z; Ramsay, DS; Zou, J, 2016) |
| "An initial administration of 60% nitrous oxide (N(2)O) evokes hypothermia in rats and if the administration continues for more than 1-2h, acute tolerance typically develops such that the initial reduction in core temperature (Tc) reverses and Tc recovers toward control values." | 3.77 | Nitrous oxide causes a regulated hypothermia: rats select a cooler ambient temperature while becoming hypothermic. ( Kaiyala, KJ; Ramsay, DS; Seaman, J, 2011) |
| "The objective of this study was determine if core temperature (T (core)), a common measure in drug research, can mask the variability both in underlying pharmacological effects and physiological counter-responses during an initial administration of the hypothermia-promoting drug, nitrous oxide (N(2)O)." | 3.74 | Direct evidence for systems-level modulation of initial drug (in)sensitivity in rats. ( Butt, S; Kaiyala, KJ; Ramsay, DS, 2007) |
| " We developed a novel system for simultaneously quantifying HP (indirect calorimetry), HL (direct gradient layer calorimetry), and T(c) (telemetry) during steady-state administrations of nitrous oxide (N(2)O), an inhalant with abuse potential that has been previously used to study acute and chronic tolerance development to its hypothermia-inducing property." | 3.73 | Assessment of heat production, heat loss, and core temperature during nitrous oxide exposure: a new paradigm for studying drug effects and opponent responses. ( Kaiyala, KJ; Ramsay, DS, 2005) |
| "On average, the hypothermia exhibited by rats receiving 60% nitrous oxide (N2O) eventually abates despite the continued inhalation of the drug (i." | 3.71 | Reliability of individual differences in initial sensitivity and acute tolerance to nitrous oxide hypothermia. ( Coldwell, SE; Kaiyala, KJ; Leroux, BG; Prall, CW; Ramsay, DS; Watson, CH; Woods, SC, 2001) |
| "Although inhalation of nitrous oxide (N2O) causes hypothermia in rats, there is a paucity of information as to whether tolerance develops to this effect." | 3.70 | Nitrous oxide-induced hypothermia in the rat: acute and chronic tolerance. ( Leroux, BG; Omachi, K; Prall, CW; Ramsay, DS; Seeley, RJ; Woods, SC, 1999) |
| "In an earlier study on the effect of mild hypothermia (34 degrees C) on the cerebral metabolic rate for oxygen (CMRO2) in rats, we used norepinephrine (NE) to support arterial blood pressure while inducing isoelectricity on the electroencephalogram (EEG) with thiopental (TP)." | 3.69 | Norepinephrine activation of basal cerebral metabolic rate for oxygen (CMRO2) during hypothermia in rats. ( Klementavicius, R; Melick, JA; Nemoto, EM; Yonas, H, 1996) |
| " Because mild hypothermia is common during general anesthesia, the authors sought to determine the relationship between the core temperature, adductor pollicis muscle temperature, and the twitch response of the adductor pollicis muscle, during isoflurane anesthesia in 15 patients undergoing elective surgery in which muscle relaxants were not required." | 3.67 | The relationship between adductor pollicis twitch tension and core, skin, and muscle temperature during nitrous oxide-isoflurane anesthesia in humans. ( Caldwell, JE; Heier, T; Kitts, JB; Miller, RD; Sessler, DI, 1989) |
| "Rewarming from hypothermia is often associated with an afterdrop (a further reduction in core temperature, despite cutaneous warming)." | 2.67 | Absence of nonshivering thermogenesis in anesthetized adult humans. ( Hynson, JM; McGuire, J; Moayeri, A; Sessler, DI, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (48.39) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roth, JV | 1 |
| Braitman, LE | 1 |
| Hunt, LH | 1 |
| Kaiyala, KJ | 9 |
| Ramsay, DS | 10 |
| Al-Noori, S | 2 |
| Shao, J | 1 |
| Leroux, BG | 4 |
| Woods, SC | 4 |
| Cimpan, A | 1 |
| Maltzer, Z | 1 |
| Zou, J | 1 |
| Seaman, J | 1 |
| ROSSANO, C | 2 |
| PARKHOUSE, J | 1 |
| ROLLASON, WN | 1 |
| LATHAM, JW | 1 |
| BLOCH, M | 1 |
| JONES, HD | 1 |
| MCLAREN, CA | 1 |
| Butt, S | 2 |
| Cheung, SS | 1 |
| Mekjavić, IB | 2 |
| Young, ML | 1 |
| Hanson, CW | 1 |
| Bloom, MJ | 1 |
| Savino, JS | 1 |
| Muravchick, S | 1 |
| Hynson, JM | 1 |
| Sessler, DI | 2 |
| Moayeri, A | 1 |
| McGuire, J | 1 |
| Nemoto, EM | 1 |
| Klementavicius, R | 1 |
| Melick, JA | 1 |
| Yonas, H | 1 |
| Omachi, K | 1 |
| Seeley, RJ | 1 |
| Prall, CW | 2 |
| Watson, CH | 1 |
| Coldwell, SE | 1 |
| Waterman, A | 1 |
| Passias, TC | 1 |
| Eiken, O | 1 |
| Heier, T | 1 |
| Caldwell, JE | 1 |
| Kitts, JB | 1 |
| Miller, RD | 1 |
| Lantos, J | 1 |
| Temes, G | 1 |
| Török, B | 1 |
| Linko, K | 1 |
| Meyer, JS | 1 |
| Welch, KM | 1 |
| Lewis, DG | 1 |
| Mackenzie, A | 1 |
| Evans, AT | 1 |
| Sawyer, DC | 1 |
| Krahwinkel, DJ | 1 |
| Ikeda, S | 2 |
| Smith, AL | 1 |
| Wollman, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparison of the Effect on Temperature Between Patients Induced With Intravenous Propofol vs Inhalation Induction With Sevoflurane[NCT02331108] | 331 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy: a Prospective, Randomized, Controlled Clinical Study[NCT05779176] | 252 participants (Anticipated) | Interventional | 2023-05-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Blood pressure decrease after intravenous anesthetic induction (NCT02331108)
Timeframe: intraoperative
| Intervention | percentage of patients (Number) |
|---|---|
| Propofol, Age <56 | 49 |
| Propofol With Phenylephrine, Age <56 | 29 |
Percentage of patients who had at least one temperature below 36.0 degrees C in the first hour of anesthesia (NCT02331108)
Timeframe: Intraoperative
| Intervention | Percentage (Number) |
|---|---|
| Sevoflurane in 100% Oxygen, Age <56 | 8 |
| Sevoflurane in 50% Nitrous, Age <56 | 8 |
| Propofol, Age <56 | 30 |
| Propofol With Phenylephrine, Age <56 | 8 |
| Sevoflurane in 100% Oxygen, Age >55 | 14 |
| Sevoflurane in 50% Nitrous, Age >55 | 14 |
Core temperature at 15 minute intervals (NCT02331108)
Timeframe: intraoperative
| Intervention | degree C (Mean) | |||
|---|---|---|---|---|
| 15 minute temperature | 30 minute temperature | 45 minute temperature | 60 minute temperature | |
| Propofol With Phenylephrine, Age <56 | 36.35 | 36.36 | 36.45 | 36.51 |
| Propofol, Age <56 | 35.96 | 35.95 | 36.00 | 36.03 |
| Sevoflurane in 100% Oxygen, Age <56 | 36.42 | 36.41 | 36.47 | 36.52 |
| Sevoflurane in 100% Oxygen, Age >55 | 36.34 | 36.31 | 36.29 | 36.34 |
| Sevoflurane in 50% Nitrous, Age <56 | 36.44 | 36.48 | 36.50 | 36.57 |
| Sevoflurane in 50% Nitrous, Age >55 | 36.41 | 36.38 | 36.41 | 36.44 |
1 review available for nitrous oxide and Hypothermia, Accidental
| Article | Year |
|---|---|
Relationship of cerebral blood flow and metabolism to neurological symptoms.
Topics: Acetylcholine; Animals; Autoradiography; Blood Flow Velocity; Blood Gas Analysis; Brain; Carbon Diox | 1972 |
2 trials available for nitrous oxide and Hypothermia, Accidental
| Article | Year |
|---|---|
Induction techniques that reduce redistribution hypothermia: a prospective, randomized, controlled, single blind effectiveness study.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Humans; Hypothermia; I | 2019 |
Absence of nonshivering thermogenesis in anesthetized adult humans.
Topics: Adult; Anesthesia; Body Temperature; Body Temperature Regulation; Female; Heating; Humans; Hypotherm | 1993 |
28 other studies available for nitrous oxide and Hypothermia, Accidental
| Article | Year |
|---|---|
Concentration-related metabolic rate and behavioral thermoregulatory adaptations to serial administrations of nitrous oxide in rats.
Topics: Adaptation, Physiological; Animals; Body Temperature Regulation; Energy Metabolism; Hypothermia; Loc | 2018 |
Predicting addictive vulnerability: individual differences in initial responding to a drug's pharmacological effects.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Body Temperature Regulation; Calorimet | 2015 |
Brown adipose tissue thermogenesis does not explain the intra-administration hyperthermic sign-reversal induced by serial administrations of 60% nitrous oxide to rats.
Topics: Adipose Tissue, Brown; Anesthetics, Inhalation; Animals; Body Temperature; Body Temperature Regulati | 2016 |
Nitrous oxide causes a regulated hypothermia: rats select a cooler ambient temperature while becoming hypothermic.
Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Body Temperature Regulation; Hypothermia; Male; | 2011 |
[Progress in the field of analgesia with N20-02: apparatus model K 262].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Hypothermia; Nitrous Oxide; Pain Management | 1956 |
[Progress in the field of analgesia with N20-02: apparatus model K 262].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Hypothermia; Nitrous Oxide; Pain Management | 1956 |
[Progress in the field of analgesia with N20-02: apparatus model K 262].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Hypothermia; Nitrous Oxide; Pain Management | 1956 |
[Progress in the field of analgesia with N20-02: apparatus model K 262].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Hypothermia; Nitrous Oxide; Pain Management | 1956 |
General anaesthesia as an aid to therapeutic hypothermia.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, General; Anesthesiology; Hypothermia; H | 1957 |
ANAESTHESIA FOR INTRACRANIAL ANEURYSMS.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesiology; Halothane; Humans; Hyperventilation; Hypotension | 1963 |
SOME SYSTEMIC EFFECTS OF NITROUS OXIDE.
Topics: Anesthesia; Anesthesia, General; Anesthetics; Blood Pressure; Blood Pressure Determination; Chlorpro | 1963 |
POSOPERATIVE SHVERING AND HYPOXAEMIA AFTER HALOTHANE, NITROUS OXIDE AND OXYGEN ANAESTHESIA.
Topics: Anesthesia; Anesthesia, Inhalation; Halothane; Humans; Hypothermia; Hypoxia; Nitrous Oxide; Oximetry | 1965 |
Assessment of heat production, heat loss, and core temperature during nitrous oxide exposure: a new paradigm for studying drug effects and opponent responses.
Topics: Administration, Inhalation; Animals; Body Temperature; Body Temperature Regulation; Calorimetry; Cal | 2005 |
Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats.
Topics: Animals; Body Temperature; Drug Tolerance; Hypothermia; Male; Nitrous Oxide; Random Allocation; Rats | 2005 |
Systems-level adaptations explain chronic tolerance development to nitrous oxide hypothermia in young and mature rats.
Topics: Administration, Inhalation; Allostasis; Animals; Body Temperature; Body Temperature Regulation; Calo | 2007 |
Direct evidence for systems-level modulation of initial drug (in)sensitivity in rats.
Topics: Administration, Inhalation; Animals; Body Temperature; Body Temperature Regulation; Calorimetry; Cal | 2007 |
Human temperature regulation during subanesthetic levels of nitrous oxide-induced narcosis.
Topics: Adult; Body Temperature Regulation; Electromyography; Humans; Hypothermia; Immersion; Male; Nitrous | 1995 |
Localized hypothermia influences assessment of recovery from vecuronium neuromuscular blockade.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Arm; Body Temperature; Electromyograph | 1994 |
Norepinephrine activation of basal cerebral metabolic rate for oxygen (CMRO2) during hypothermia in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; B | 1996 |
Nitrous oxide-induced hypothermia in the rat: acute and chronic tolerance.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Body Temperature; Conditioning, Classi | 1999 |
Reliability of individual differences in initial sensitivity and acute tolerance to nitrous oxide hypothermia.
Topics: Anesthetics, Inhalation; Animals; Body Temperature; Drug Tolerance; Hypothermia; Individuality; Male | 2001 |
Accidental hypothermia during anaesthesia in dogs and cats.
Topics: Alfaxalone Alfadolone Mixture; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; | 1975 |
The effect of 30% nitrous oxide on thermoregulatory responses in humans during hypothermia.
Topics: Administration, Inhalation; Body Temperature; Body Temperature Regulation; Carbon Dioxide; Heart Rat | 1992 |
The relationship between adductor pollicis twitch tension and core, skin, and muscle temperature during nitrous oxide-isoflurane anesthesia in humans.
Topics: Anesthesia, Inhalation; Body Temperature; Electric Stimulation; Humans; Hypothermia; Hypothermia, In | 1989 |
Changes during ischaemia in extracellular potassium ion concentration of the brain under nitrous oxide or hexobarbital-sodium anaesthesia and moderate hypothermia.
Topics: Anesthesia; Animals; Body Temperature; Brain; Brain Ischemia; Dogs; Electroencephalography; Extracel | 1986 |
The clinical efficiency of the Portex in-line blood warmer.
Topics: Anesthesia, General; Blood Preservation; Blood Transfusion; Cold Temperature; Enflurane; Fentanyl; H | 1986 |
The effect of mild hypothermia and hyperventilation on acid-base balance in major vascular surgery.
Topics: Acid-Base Equilibrium; Aged; Anesthesia, General; Aorta, Abdominal; Blood; Blood Transfusion; Blood | 1972 |
Effect of a warm-water blanket on development of hypothermia during small animal surgery.
Topics: Anesthesia, Inhalation; Animals; Body Temperature; Cat Diseases; Cats; Dog Diseases; Dogs; Esophagus | 1973 |
Measuring cerebral blood flow by the nitrous oxide method.
Topics: Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Humans; Hypothermia; Methods; Nitrous Oxide | 1972 |
Measuring cerebral blood flow by the nitrous oxide method.
Topics: Brain; Cerebrovascular Circulation; Humans; Hypothermia; Methods; Nitrous Oxide; Postural Balance | 1972 |
[Experimental study on the uptake of nitrous oxide in the brain in hypothermia].
Topics: Anesthesia; Animals; Brain; Chromatography, Gas; Dogs; Hemodynamics; Hypothermia; Nitrous Oxide; Reg | 1969 |