nitrous oxide and Hemorrhage studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Research Excerpts

Excerpt	Relevance	Reference
"The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia."	7.72	Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. ( Boemke, W; Francis, RC; Frerking, I; Höhne, C; Kaczmarczyk, G; Swenson, ER; Vogler, P, 2004)
" Desflurane, with the characteristics of rapid onset and minimal metabolism, may provide better analgesia and safety for labour pain control."	5.08	Desflurane analgesia for vaginal delivery. ( Abboud, TK; Donovan, MM; Peres Da Silva, E; Swart, F; Yakal, K; Zhu, J, 1995)
"The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia."	3.72	Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. ( Boemke, W; Francis, RC; Frerking, I; Höhne, C; Kaczmarczyk, G; Swenson, ER; Vogler, P, 2004)
"The cardiovascular effects of halothane-nitrous oxide anesthesia, and beta-receptor blockade with either propranolol or practolol, were studied in 15 dogs in which severe myocardial infarction had been induced ten days earlier."	3.65	Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction. ( Bennett, MJ; Clarke, TN; Foëx, P; Prys-Roberts, C; Roberts, JG; Ryder, WA, 1976)
"The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr."	3.65	Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats. ( Sokoll, MD; Stullken, EH, 1975)
"Nausea was significantly less among methoxyflurane patients, and vomiting during labour occurred only in patients who had nitrous oxide."	2.63	Methoxyflurane and nitrous oxide as obstetric analgesics. I. A comparison by continuous administration. ( Jones, EV; Jones, PL; Mushin, WW; Rosen, M, 1969)
"So-called epinephrine-induced arrhythmia with halothane anesthesia occurred in 1 of 34 instances with 1:300,000 solution and in 5 of 48 instances with 1:100,000 solution."	1.26	Hemodynamic effects of locally applied epinephrine used with various general anesthetic techniques. ( Funakoshi, Y; Iuchi, Y; Iwai, S; Kaneda, H, 1977)

Research

Studies (46)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants Experiencing Side Effects (Nausea, Dizziness)

Number of Participants Needing Intervention to Treat Blood Loss (a Composite of Use of Uterotonics, Re-aspiration, and Bimanual Massage)

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (84.78)	18.7374
1990's	4 (8.70)	18.2507
2000's	3 (6.52)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Chi, C	1
Lee, CA	1
England, A	1
Hingorani, J	1
Paintsil, J	1
Kadir, RA	1
TUOHY, GF	1
THEYE, RA	1
GORHAM, AP	1
Höhne, C	1
Vogler, P	1
Frerking, I	1
Francis, RC	1
Swenson, ER	1
Kaczmarczyk, G	1
Boemke, W	1
Takizawa, D	1
Sato, E	1
Kurosaki, D	1
Hiraoka, H	1
Saito, S	1
Goto, F	1
Stallabrass, P	1
Abboud, TK	1
Swart, F	1
Zhu, J	1
Donovan, MM	1
Peres Da Silva, E	1
Yakal, K	1
Dilger, JA	1
Tetzlaff, JE	1
Bell, GR	1
Kosmorsky, GS	1
Agnor, RC	1
O'Hara, JF	1
Ziora, D	1
Kozielski, J	1
Oklek, K	1
Prys-Roberts, C	1
Roberts, JG	1
Foëx, P	1
Clarke, TN	1
Bennett, MJ	1
Ryder, WA	1
Funakoshi, Y	1
Iwai, S	1
Kaneda, H	1
Iuchi, Y	1
Fineberg, HV	1
Gabel, RA	1
Sosman, MB	1
Brown, ES	1
Rheindorf, P	1
Raj, PP	1
Montgomery, SJ	1
Bradley, VH	1
Doom, A	1
Mundeleer, P	1
Batchelder, BM	1
Cooperman, LH	2
Baskett, PJ	1
Zorab, JS	1
Stullken, EH	1
Sokoll, MD	1
Patterson, ME	1
Bartlett, PC	1
Van Leeuwen, AF	1
Evans, RG	1
Ludbrook, J	1
Iushkova, LA	1
Lugovskiĭ, VK	1
Ohlgisser, M	1
Sorokin, Y	1
Heifetz, M	1
Weiskopf, RB	1
Bogetz, MS	1
Askerkhanov, RP	1
Tlapshokov, BKh	1
Edgerton, WD	1
Forrest, WH	1
Deacock, AR	1
McNeill, TW	1
DeWald, RL	1
Kuo, KN	1
Bennett, EJ	1
Salem, MR	1
Shin, FT	1
Jones, RS	1
Irving, IM	1
Sells, RA	1
Jagger, DW	1
Miller, JF	1
Elstein, M	1
Allen, TH	1
Steven, IM	1
Sweeney, DB	1
Miroshnichenko, VP	1
Goncharenko, VV	1
Moir, DD	2
Harrison, GA	1
Bailey, RJ	1
Thomson, PG	1
Inada, Y	1
Jones, PL	2
Rosen, M	2
Mushin, WW	2
Jones, EV	2
Rolly, G	1
Reske-Nielsen, E	1
Kratholm, S	1
Thomford, NR	1
Hamelberg, WE	1
Wiederholt, WC	1
Knape, H	1
Bergmann, H	1
Krumpholz, K	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures: Does it Increase Blood Loss and Interventions for Blood Loss and Why Do Anesthesiologists Choose to Use It?[NCT01048658]	Phase 4	160 participants (Actual)	Interventional	2009-09-30	Completed
Opioid Free Versus Opioid Balanced Anesthesia in Middle Ear Surgery.[NCT03809949]	Phase 4	60 participants (Actual)	Interventional	2019-01-16	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
Sevoflurane	13
No Sevoflurane	11

Provider report for need to intervene due to blood loss (yes/no) (NCT01048658)
Timeframe: At time of uterine evacuation and immediately post-operatively, an average of 7.1 minutes

Number of Participants With Estimated Blood Loss Greater Than 300 mL (Yes/no)

Intervention	Participants (Count of Participants)
Sevoflurane	20
No Sevoflurane	13

Procedural blood loss greater than 300 mL. Blood loss was measured in a standardized fashion (amniotic fluid was discarded, blood was separated from tissue, and all gauze surgical drapes weighed). (NCT01048658)
Timeframe: At time of uterine evacuation, an average of 7.1 minutes

Procedure Time: T-test (Time of Speculum Placement to Time Speculum Removed)

Intervention	Participants (Count of Participants)
Sevoflurane	12
No Sevoflurane	6

Length of procedure from time of speculum placement to time of speculum removal, in minutes. (NCT01048658)
Timeframe: Time of speculum place to time of speculum removal, an average of 7.1 minutes

Patient and Provider Satisfaction With Anesthesia

Intervention	minutes (Mean)
Sevoflurane	7.0
No Sevoflurane	7.3

Scores reported on 10-cm Visual Analog Scale (VAS anchors: 0= not satisfied at all, 10= completely satisfied) . Reported as mean +/- standard deviation. Subjects and providers were blinded to anesthesia method. Subjects and providers completed post-operative questionnaire within 30 minutes of procedure completion. (NCT01048658)
Timeframe: Post-procedure, within 30 minutes

Article	Year
Effects of anesthetics on splanchnic circulation and metabolism. The Surgical clinics of North America, 1975, Volume: 55, Issue:4 Topics: Abdomen; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics; Autonomic Agents; Cyclopropanes; Dep	1975
Gynecologic laparoscopy. A review article. Obstetrical & gynecological survey, 1985, Volume: 40, Issue:7 Topics: Anesthesia, General; Anesthesia, Local; Animals; Arrhythmias, Cardiac; Carbon Dioxide; Dogs; Extrava	1985
Effects of anaesthetics on the splanchnic circulation. British journal of anaesthesia, 1972, Volume: 44, Issue:9 Topics: Anesthesia, General; Anesthesia, Spinal; Anesthetics; Animals; Blood Volume; Carbon Dioxide; Cyclopr	1972
[Information on pharmacological action of halothane, duration of halothane anesthesia and combined administration with other anesthetic agents. Orientation for surgeons]. Geka chiryo. Surgical therapy, 1969, Volume: 20, Issue:2 Topics: Acid-Base Equilibrium; Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchi; Depression, Chemical;	1969

Article	Year
Desflurane analgesia for vaginal delivery. Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:2 Topics: Acid-Base Equilibrium; Adaptation, Physiological; Adult; Analgesia, Obstetrical; Anesthetics, Inhala	1995
[Usefulness of cryoapplication for bleeding after needle biopsy during fiberoptic bronchoscopy]. Pneumonologia i alergologia polska, 1997, Volume: 65, Issue:11-12 Topics: Adult; Aerosol Propellants; Aged; Biopsy, Needle; Bronchoscopy; Cryotherapy; Female; Fiber Optic Tec	1997
Methoxyflurane and nitrous oxide as obstetric analgesics. I. A comparison by continuous administration. British medical journal, 1969, Aug-02, Volume: 3, Issue:5665 Topics: Adult; Anesthesia, Obstetrical; Clinical Trials as Topic; Consciousness; Female; Hemorrhage; Humans;	1969
Methoxyflurane and nitrous oxide as obstetric analgesics. II. A comparison by self-administered intermittent inhalation. British medical journal, 1969, Aug-02, Volume: 3, Issue:5665 Topics: Adult; Anesthesia, Obstetrical; Clinical Trials as Topic; Consciousness; Female; Hemorrhage; Humans;	1969
Anaesthesia for Caesarean section. An evaluation of a method using low concentrations of halothane and 50 per cent of oxygen. British journal of anaesthesia, 1970, Volume: 42, Issue:2 Topics: Anesthesia, Obstetrical; Blood Pressure; Cesarean Section; Cognition; Female; Halothane; Hemorrhage;	1970

Article	Year
Obstetric analgesia and anaesthesia in women with inherited bleeding disorders. Thrombosis and haemostasis, 2009, Volume: 101, Issue:6 Topics: Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Combined; Blood Coag	2009
COMPARATIVE HAEMODYNAMICS DURING OPERATION, UNREPLACED BLOOD LOSS, AND ANAESTHESIA WITH ETHER OR HALOTHANE IN NITROUS OXIDE AND OXYGEN. British journal of anaesthesia, 1964, Volume: 36 Topics: Anesthesia; Anesthesia, Inhalation; Biomedical Research; Blood Circulation; Blood Flow Velocity; Blo	1964
THE ROLE OF THE ANAESTHETIST IN THE MANAGEMENT OF POST--TONSILLECTOMY HAEMORRHAGE IN CHILDREN. Anaesthesia, 1964, Volume: 19 Topics: Anesthesia; Anesthesia, Inhalation; Child; Ether; Gastric Lavage; Hemorrhage; Humans; Nitrous Oxide;	1964
Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. Anesthesiology, 2004, Volume: 100, Issue:4 Topics: Anesthesia; Angiotensin II; Animals; Blood Pressure; Cardiac Output; Catecholamines; Dogs; Female; G	2004
Changes in unbound concentration of propofol during hemorrhage. Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:1 Topics: Anesthesia; Blood Pressure; Blood Transfusion; Dopamine; Female; Fentanyl; Heart Rate; Hemorrhage; H	2005
Halothane and blood loss at delivery. Acta anaesthesiologica Scandinavica. Supplementum, 1966, Volume: 25 Topics: Anesthesia, Obstetrical; Cyclopropanes; Delivery, Obstetric; Female; Halothane; Hemoglobins; Hemorrh	1966
Ischaemic optic neuropathy after spinal fusion. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:1 Topics: Adult; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Loss, Surgi	1998
Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction. Anesthesiology, 1976, Volume: 45, Issue:3 Topics: Acetylcholine; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Coronary Circulation; Dogs	1976
Hemodynamic effects of locally applied epinephrine used with various general anesthetic techniques. Journal of oral surgery (American Dental Association : 1965), 1977, Volume: 35, Issue:9 Topics: Alcuronium; Analysis of Variance; Anesthesia, General; Anesthetics; Arrhythmias, Cardiac; Atropine;	1977
Acquisition and application of new medical knowledge by anesthesiologists: three recent examples. Anesthesiology, 1978, Volume: 48, Issue:6 Topics: Abortion, Therapeutic; Anesthesiology; Anesthetics; Communication; Education, Medical, Continuing; F	1978
Anesthesia in pediatric otorhinolaryngology. Otolaryngologic clinics of North America, 1977, Volume: 10, Issue:1 Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Arrhythmias, Cardiac; Child; Epinephrin	1977
[Narcosis as anesthesia in middle ear surgery (author's transl)]. HNO, 1976, Volume: 24, Issue:1 Topics: Anesthesia; Ear, Middle; Hemorrhage; Humans; Nitrous Oxide; Pressure	1976
Intraoperative patient care. Agents and technics. Clinical anesthesia, 1976, Volume: 11, Issue:2 Topics: Adjuvants, Pharmaceutic; Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthetics; Cervi	1976
Study on peroperative bleeding in ear, nose and throat surgery. Acta anaesthesiologica Belgica, 1976, Volume: 27 suppl Topics: Anesthesia, General; Blood Pressure; Ear, Middle; Furosemide; Halothane; Hemorrhage; Humans; Microsu	1976
Priorities in the immediate care of roadside and other traumatic casualties. Anaesthesia, 1975, Volume: 30, Issue:1 Topics: Abdominal Injuries; Accidents, Traffic; Airway Obstruction; Analgesia; Blood Transfusion; Craniocere	1975
Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats. Anesthesiology, 1975, Volume: 42, Issue:4 Topics: Anesthesia, Inhalation; Animals; Cats; Electroencephalography; Ephedrine; Ferricyanides; Hemorrhage;	1975
Hearing impairment caused by intratympanic pressure changes during general anesthesia. The Laryngoscope, 1976, Volume: 86, Issue:3 Topics: Adult; Anesthesia, Inhalation; Deafness; Ear Ossicles; Ear, Middle; Female; Hemorrhage; Humans; Male	1976
Effects of halothane, ketamine, propofol and alfentanil anaesthesia on circulatory control in rabbits. Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:11 Topics: Alfentanil; Anesthetics; Animals; Blood Pressure; Blood Volume; Halothane; Heart Rate; Hemorrhage; K	1990
[Comparative study of hematologic indicators in poisoning in relation to the degree of blood loss in animals]. Gigiena i sanitariia, 1989, Issue:3 Topics: Animals; Benzoates; Hematopoiesis; Hemorrhage; Leukocyte Count; Leukocytes; Male; Nitrous Oxide; Rat	1989
Cardiovascular actions of nitrous oxide or halothane in hypovolemic swine. Anesthesiology, 1985, Volume: 63, Issue:5 Topics: Anesthesia; Animals; Blood Volume; Epinephrine; Halothane; Hemodynamics; Hemorrhage; Nitrous Oxide;	1985
[The relationship between changes in blood coagulation among persons of advanced and old age and pathology, anesthesia, surgery and complications]. Vestnik khirurgii imeni I. I. Grekova, 1972, Volume: 108, Issue:6 Topics: Aged; Anesthesia, Endotracheal; Anesthesia, Local; Blood Coagulation Disorders; Cholelithiasis; Ethy	1972
Laparoscopy in the community hospital: set-up, performance, control. The Journal of reproductive medicine, 1974, Volume: 12, Issue:6 Topics: Abscess; Burns, Electric; Electrosurgery; Female; Gynecology; Halothane; Hematoma; Hemorrhage; Hospi	1974
Effects of anesthesia in therapeutic abortion. Anesthesiology, 1970, Volume: 33, Issue:1 Topics: Abortion, Therapeutic; Anesthesia, Obstetrical; Anesthetics; Ethers; Halothane; Hemorrhage; Nitrous	1970
Aspects of anaesthesia for middle ear surgery an blood loss during stapedectomy. Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:12 Topics: Adrenergic beta-Antagonists; Anesthesia, General; Ear, Middle; Epinephrine; Hemorrhage; Humans; Hypo	1971
Controlled hypotensive anesthesia in scoliosis surgery. The Journal of bone and joint surgery. American volume, 1974, Volume: 56, Issue:6 Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Benperidol; Child; Fentanyl; Halothane; Hemorrhage; H	1974
Some anaesthetic problems in corrective spinal surgery in children in Hong Kong. Anaesthesia and intensive care, 1973, Volume: 1, Issue:4 Topics: Anesthesia; Anesthesia, General; Blood Transfusion; Child; Hemorrhage; Hong Kong; Humans; Intubation	1973
Hepatic transplantation in the neonatal pig. British journal of anaesthesia, 1973, Volume: 45, Issue:11 Topics: Acidosis; Anesthesia, General; Animals; Animals, Newborn; Arteriovenous Shunt, Surgical; Blood Trans	1973
A comparison of electrocautery and cryocautery for the treatment of cervical erosions and chronic cervicitis. The Journal of obstetrics and gynaecology of the British Commonwealth, 1973, Volume: 80, Issue:7 Topics: Cryosurgery; Electrocoagulation; Female; Hemorrhage; Humans; Nitrous Oxide; Outpatient Clinics, Hosp	1973
The bleeding tonsil--anaesthesia for control of haemorrhage after tonsillectomy. Anaesthesia and intensive care, 1973, Volume: 1, Issue:6 Topics: Anesthesia; Anesthesia, Inhalation; Bis-Trimethylammonium Compounds; Blood Transfusion; Ethyl Ethers	1973
[Effect of certain types of anesthesia on the extent of blood loss in labor using operations applying obstetrical forceps]. Pediatriia akusherstvo i ginekologiia, 1973, Volume: 6 Topics: Adult; Anesthesia, Obstetrical; Ethyl Ethers; Female; Halothane; Hemorrhage; Humans; Nitrous Oxide;	1973
Blood loss during major vaginal surgery. A statistical study of the influence of general anaesthesia and epidural analgesia. British journal of anaesthesia, 1968, Volume: 40, Issue:4 Topics: Adult; Age Factors; Aged; Anesthesia, General; Anesthesia, Spinal; Female; Halothane; Hemorrhage; Hu	1968
A heart transplantation. 4. Anaesthesia and cardio-pulmonary bypass. The Medical journal of Australia, 1969, Mar-29, Volume: 1, Issue:13 Topics: Acidosis; Anesthesia, General; Anuria; Atropine; Australia; Blood Pressure; Coronary Vessels; Extrac	1969
Anesthesia for renal transplantation: First experiences. Der Anaesthesist, 1969, Volume: 18, Issue:8 Topics: Adolescent; Adult; Anesthesia, Endotracheal; Blood Transfusion; Female; Halothane; Hemorrhage; Human	1969
Malignant hyperthermia. A fatal case provoked by anaesthesia in asymptomatic encephalitis? Acta anaesthesiologica Scandinavica, 1971, Volume: 15, Issue:4 Topics: Acidosis; Anesthesia; Autopsy; Bicarbonates; Brain Edema; Central Nervous System; Child; Fever; Halo	1971
Sudden hyperpyrexia during general anesthesia. Surgery, 1969, Volume: 66, Issue:5 Topics: Adult; Anesthesia, Inhalation; Brain Diseases; Cerebral Cortex; Edema; Fever; Hemorrhage; Hernia, In	1969
A comparison of neuroleptanesthesia and halothane in neurosurgery. Archivum chirurgicum Neerlandicum, 1970, Volume: 22, Issue:4 Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta	1970
[On the problem of anesthesic in tonsillectomy with the head down position]. Wiener medizinische Wochenschrift (1946), 1969, Jun-21, Volume: 119, Issue:25 Topics: Adolescent; Anesthesia, Endotracheal; Anesthesia, Intravenous; Anesthetics; Child, Preschool; Glycol	1969

nitrous oxide and Hemorrhage