nitrous oxide has been researched along with Glioma in 9 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 8 patients with frontotemporal gliomas, middle cerebral artery blood flow velocity (VMCA), pulsatality index (PI) and resistance index (RI) were determined in the normal and pathological cerebral hemispheres before and after stable nitrous oxide-halothane anesthesia." | 9.11 | Cerebral blood flow velocity changes under nitrous oxide halothane anesthesia in patients with frontotemporal gliomas: a comparison of the normal and abnormal cerebral hemispheres. ( Pillai, SV; Umamaheswara Rao, GS; Vajramuni, GV, 2004) |
| "Cobalamin metabolism and function were investigated at the levels from transcobalamin II (TCII) receptor to the cobalamin-dependent enzymes, methionine synthase and methylmalonyl-CoA mutase, in a methionine-dependent (P60) and a methionine-independent (P60H) glioma cell line." | 7.70 | Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line. ( Banerjee, R; Berge, RK; Bose, S; Fiskerstrand, T; Gulati, S; Pezacka, EH; Refsum, H; Riedel, B; Seetharam, B; Ueland, PM, 1998) |
| "We investigated the co-ordinate variations of the two cobalamin (Cbl)-dependent enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MCM), and measured the levels of their respective cofactors, methylcobalamin (CH3Cbl) and adenosylcobalamin (AdoCbl) in cultured human glioma cells during nitrous oxide exposure and during a subsequent recovery period of culture in a nitrous oxide-free atmosphere (air)." | 7.70 | Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase. ( Fiskerstrand, T; Refsum, H; Riedel, B; Ueland, PM, 1999) |
| "In 8 patients with frontotemporal gliomas, middle cerebral artery blood flow velocity (VMCA), pulsatality index (PI) and resistance index (RI) were determined in the normal and pathological cerebral hemispheres before and after stable nitrous oxide-halothane anesthesia." | 5.11 | Cerebral blood flow velocity changes under nitrous oxide halothane anesthesia in patients with frontotemporal gliomas: a comparison of the normal and abnormal cerebral hemispheres. ( Pillai, SV; Umamaheswara Rao, GS; Vajramuni, GV, 2004) |
| "Cobalamin metabolism and function were investigated at the levels from transcobalamin II (TCII) receptor to the cobalamin-dependent enzymes, methionine synthase and methylmalonyl-CoA mutase, in a methionine-dependent (P60) and a methionine-independent (P60H) glioma cell line." | 3.70 | Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line. ( Banerjee, R; Berge, RK; Bose, S; Fiskerstrand, T; Gulati, S; Pezacka, EH; Refsum, H; Riedel, B; Seetharam, B; Ueland, PM, 1998) |
| "We investigated the co-ordinate variations of the two cobalamin (Cbl)-dependent enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MCM), and measured the levels of their respective cofactors, methylcobalamin (CH3Cbl) and adenosylcobalamin (AdoCbl) in cultured human glioma cells during nitrous oxide exposure and during a subsequent recovery period of culture in a nitrous oxide-free atmosphere (air)." | 3.70 | Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase. ( Fiskerstrand, T; Refsum, H; Riedel, B; Ueland, PM, 1999) |
| "We compared the metabolic response of a methionine(Met)-dependent (P60) human glioma cell line with that of a Met-independent variant (P60H) when cultured in a homocysteine (Hcy) medium and exposed to N2O." | 3.69 | Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence. ( Fiskerstrand, T; Refsum, H; Ueland, PM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Watts, JM | 1 |
| Whitlow, CT | 1 |
| Maldjian, JA | 1 |
| Vajramuni, GV | 1 |
| Umamaheswara Rao, GS | 1 |
| Pillai, SV | 1 |
| Todd, MM | 1 |
| Warner, DS | 1 |
| Sokoll, MD | 1 |
| Maktabi, MA | 1 |
| Hindman, BJ | 1 |
| Scamman, FL | 1 |
| Kirschner, J | 1 |
| Fiskerstrand, T | 3 |
| Ueland, PM | 3 |
| Refsum, H | 3 |
| Pechstein, U | 1 |
| Nadstawek, J | 1 |
| Zentner, J | 1 |
| Schramm, J | 1 |
| Riedel, B | 2 |
| Seetharam, B | 1 |
| Pezacka, EH | 1 |
| Gulati, S | 1 |
| Bose, S | 1 |
| Banerjee, R | 1 |
| Berge, RK | 1 |
| Holman, BL | 1 |
| Jennett, WB | 1 |
| Barker, J | 1 |
| Fitch, W | 1 |
| McDowall, DG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883] | Phase 3 | 69 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) | |||
| Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874] | Phase 3 | 50 participants (Actual) | Interventional | 2020-09-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
| Intervention | units on a scale 0-3 (Mean) |
|---|---|
| Furosemide | 1.5 |
| Placebo | 1.3 |
2 reviews available for nitrous oxide and Glioma
| Article | Year |
|---|---|
Clinical applications of arterial spin labeling.
Topics: Body Water; Brain Death; Brain Diseases; Brain Neoplasms; Cerebral Arteries; Cerebrovascular Circula | 2013 |
Concepts and clinical utility of the measurement of cerebral blood flow.
Topics: Brain Diseases; Brain Injuries; Brain Neoplasms; Carbon Dioxide; Carotid Artery Thrombosis; Cerebrov | 1976 |
4 trials available for nitrous oxide and Glioma
3 other studies available for nitrous oxide and Glioma
| Article | Year |
|---|---|
Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analgesics, Non-Narcotic; Glioma; Homocys | 1997 |
Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Feedback; Glioma; Homocysteine; Humans; M | 1998 |
Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aerobiosis; Anesthetics, Inhalation; Coba | 1999 |