Page last updated: 2024-10-19

nitrous oxide and Folic Acid Deficiency

nitrous oxide has been researched along with Folic Acid Deficiency in 14 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19909 (64.29)18.7374
1990's1 (7.14)18.2507
2000's4 (28.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Weimann, J1
Myles, PS1
Chan, MT1
Forbes, A1
Leslie, K1
Paech, M1
Peyton, P1
Amos, RJ2
Amess, JA2
Hinds, CJ2
Mollin, DL2
Lindenbaum, J1
Lumb, M2
Perry, J2
Deacon, R2
Chanarin, I2
Schneede, J1
Refsum, H1
Ueland, PM1
Deleu, D1
Hanssens, Y1
Louon, A1
Beard, ME1
Hamer, JW1
Armstrong, P1
Rae, PW1
Gray, WM1
Spence, AA1
Muir, M1
Shane, B1
Stokstad, EL1
Hansen, DK1
Billings, RE1
Sourial, NA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Folic Acid Clinical Trial (FACT): Biomarker Subgroup Analysis[NCT03981029]51 participants (Actual)Observational2011-12-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for nitrous oxide and Folic Acid Deficiency

ArticleYear
Toxicity of nitrous oxide.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Animals; Bone Marrow; Folic Acid Deficiency; Humans; Methionine; Nervous System Diseases; Nitrous Ox

2003
Drugs and vitamin B12 and folate metabolism.
    Current concepts in nutrition, 1983, Volume: 12

    Topics: Alcoholism; Animals; Anticonvulsants; Ascorbic Acid; Contraceptives, Oral; Folic Acid; Folic Acid An

1983
Biological and environmental determinants of plasma homocysteine.
    Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3

    Topics: Adult; Aged; Aging; Alcohol Drinking; Child; Cystathionine beta-Synthase; Diagnosis-Related Groups;

2000
Cobalamin-folate interrelations: a critical review.
    Blood, 1985, Volume: 66, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central N

1985
Vitamin B12-folate interrelationships.
    Annual review of nutrition, 1985, Volume: 5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Bone Marrow; Folic

1985

Other Studies

9 other studies available for nitrous oxide and Folic Acid Deficiency

ArticleYear
Preoperative folate and homocysteine status in patients undergoing major surgery.
    Clinical nutrition (Edinburgh, Scotland), 2006, Volume: 25, Issue:5

    Topics: Anesthetics, Inhalation; Dietary Supplements; Fasting; Female; Folic Acid; Folic Acid Deficiency; Ho

2006
Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care.
    Lancet (London, England), 1982, Oct-16, Volume: 2, Issue:8303

    Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Anesthesia; Bone Marrow; Child;

1982
Urinary folate loss following inactivation of vitamin B12 by nitrous oxide in rats.
    British journal of haematology, 1982, Volume: 51, Issue:2

    Topics: Animals; Chromatography, DEAE-Cellulose; Folic Acid; Folic Acid Deficiency; Liver; Male; Nitrous Oxi

1982
Nitrous oxide-induced cobalamin deficiency.
    Archives of neurology, 2001, Volume: 58, Issue:1

    Topics: Folic Acid Deficiency; Humans; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12 Deficiency

2001
Nitrous oxide and the bone-marrow.
    Lancet (London, England), 1978, Oct-07, Volume: 2, Issue:8093

    Topics: Anemia, Megaloblastic; Bone Marrow; Critical Care; Folic Acid Deficiency; Humans; Nitrous Oxide

1978
Nitrous oxide and formiminoglutamic acid: excretion in surgical patients and anaesthetists.
    British journal of anaesthesia, 1991, Volume: 66, Issue:2

    Topics: Adult; Anesthesia, Inhalation; FIGLU Test; Folic Acid Deficiency; Humans; Middle Aged; Nitrous Oxide

1991
Effects of nitrous oxide on maternal and embryonic folate metabolism in rats.
    Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Body Weight; Chromatography, Hig

1985
Re: Effect of nitrous oxide on human bone marrow cells and its synergistic effect with methionine and methotrexate on functional folate deficiency.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Bone Marrow; Cells, Cultured; Drug Synergism; Folic Acid Deficiency; Humans; Methionine; Methotrexat

1985
Investigations into the effect of nitrous oxide anaesthesia on folate metabolism in patients receiving intensive care.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985, Volume: 4, Issue:5

    Topics: Adolescent; Adult; Aged; Anesthesia; Bone Marrow; Child; Critical Care; Deoxyuridine; Erythrocytes;

1985