Page last updated: 2024-10-19

nitrous oxide and Experimental Lung Inflammation

nitrous oxide has been researched along with Experimental Lung Inflammation in 11 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Experimental Lung Inflammation: Inflammation of any part, segment or lobe, of the lung parenchyma.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group."9.08[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998)
"Nitrous oxide promotes absorption atelectasis in poorly ventilated lung segments at high inspired concentrations."5.69Postoperative Pulmonary Complications in the ENIGMA II Trial: A Post Hoc Analysis. ( Chee, B; Desai, M; Etherington, C; Ho, A; Leslie, K; Liskaser, G; Marsh, H; Myles, PS; Perrett, G; Peyton, PJ; Torlot, F, 2023)
"To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group."5.08[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998)
" The results of meta-analyses showed that nitrous oxide-based techniques increased the incidence of pulmonary atelectasis (odds ratio (OR) 1."4.91Nitrous oxide-based techniques versus nitrous oxide-free techniques for general anaesthesia. ( Jia, RH; Jia, WQ; Kuriyama, A; Liu, Y; Luo, XF; Ma, B; Sun, R; Tian, JH; Yang, K; Zhang, P, 2015)
"The annual death rate from drug abuse for teenagers increased from 1."1.37Trends and pattern of drug abuse deaths in Maryland teenagers. ( Fowler, DR; Levine, B; Li, G; Li, L; Zhang, X; Zielke, HR, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19904 (36.36)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's2 (18.18)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Peyton, PJ1
Liskaser, G1
Ho, A1
Marsh, H1
Etherington, C1
Torlot, F1
Desai, M1
Perrett, G1
Chee, B1
Leslie, K2
Myles, PS2
Sun, R1
Jia, WQ1
Zhang, P1
Yang, K1
Tian, JH1
Ma, B1
Liu, Y1
Jia, RH1
Luo, XF1
Kuriyama, A1
Kumakura, S1
Kikuchi, T1
Yamaguchi, K1
Kugimiya, T1
Inada, E1
Peyton, P1
Paech, M1
Forbes, A1
Chan, MT1
Sessler, D1
Devereaux, PJ1
Silbert, BS1
Jamrozik, K1
Beattie, S1
Badner, N1
Tomlinson, J1
Wallace, S1
Bertoletti, L1
Robert, A1
Cottier, M1
Chambonniere, ML1
Vergnon, JM1
Li, L1
Zhang, X1
Levine, B1
Li, G1
Zielke, HR1
Fowler, DR1
GRAYSON, RR1
URBACH, KF1
LEE, WR1
SHEELY, LL1
LANG, FL1
SHARP, RP1
Arandia, HY1
Grogono, AW1
Garcia, J1
Roure, P1
Hayem, C1
Dupont, D1
Pulatov, AT1
Sultanov, ShR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).[NCT00430989]Phase 47,112 participants (Actual)Interventional2007-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cardiac Arrest

(NCT00430989)
Timeframe: 30 days

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)15
N2O Free Group (FiO2 0.3)19

Hospital Stay (Days)

(NCT00430989)
Timeframe: 30 Days Post Op

InterventionDays (Median)
Nitrous Oxide: 70% N2O (FiO2 0.3)6.1
N2O Free Group (FiO2 0.3)6.1

Myocardial Infarction (MI)

(NCT00430989)
Timeframe: 30 days post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)215
N2O Free Group (FiO2 0.3)219

Pulmonary Embolism

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
N2O Group (FiO2 0.3)18
N2O Free Group (FiO2 0.3)22

Stroke

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)26
N2O Free Group (FiO2 0.3)19

The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.

(NCT00430989)
Timeframe: 30 days post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)283
N2O Free Group (FiO2 0.3)296

Wound Infection

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)321
N2O Free Group (FiO2 0.3)311

Reviews

1 review available for nitrous oxide and Experimental Lung Inflammation

ArticleYear
Nitrous oxide-based techniques versus nitrous oxide-free techniques for general anaesthesia.
    The Cochrane database of systematic reviews, 2015, Nov-06, Issue:11

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Humans; Myocardial Infarction; Nausea; Nitrous

2015

Trials

5 trials available for nitrous oxide and Experimental Lung Inflammation

ArticleYear
Postoperative Pulmonary Complications in the ENIGMA II Trial: A Post Hoc Analysis.
    Anesthesiology, 2023, 04-01, Volume: 138, Issue:4

    Topics: Anesthesia, General; Australia; Humans; Lung; Nitrous Oxide; Oxygen; Pneumonia; Postoperative Compli

2023
[Exposure to nitrous oxide may increase airway inflammation during sevoflurane anesthesia].
    Masui. The Japanese journal of anesthesiology, 2008, Volume: 57, Issue:10

    Topics: Adult; Aged; Anesthesia, General; Biomarkers; Enzyme-Linked Immunosorbent Assay; Epithelium; Female;

2008
Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: rationale and design.
    American heart journal, 2009, Volume: 157, Issue:3

    Topics: Aged; Anesthetics, Inhalation; Cardiovascular Diseases; Female; Homocysteine; Humans; Length of Stay

2009
Accuracy and feasibility of electromagnetic navigated bronchoscopy under nitrous oxide sedation for pulmonary peripheral opacities: an outpatient study.
    Respiration; international review of thoracic diseases, 2009, Volume: 78, Issue:3

    Topics: Aged; Anesthetics, Inhalation; Bronchoscopy; Diagnostic Errors; Electromagnetic Fields; Female; Huma

2009
[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination].
    Revue des maladies respiratoires, 1998, Volume: 15, Issue:2

    Topics: Adjuvants, Anesthesia; Administration, Rectal; Anesthesia, Local; Anesthetics, Inhalation; Anestheti

1998

Other Studies

5 other studies available for nitrous oxide and Experimental Lung Inflammation

ArticleYear
Trends and pattern of drug abuse deaths in Maryland teenagers.
    Journal of forensic sciences, 2011, Volume: 56, Issue:4

    Topics: Adolescent; Age Distribution; Black People; Butanes; Cause of Death; Chlorofluorocarbons, Methane; C

2011
Nitrogen dioxide pneumonia: a recently discovered malady in silo-fillers.
    GP, 1957, Volume: 16, Issue:5

    Topics: Humans; Lung Diseases; Nitrogen Dioxide; Nitrous Oxide; Occupational Diseases; Pneumonia; Silo Fille

1957
SPINAL OR GENERAL ANESTHESIA FOR INGUINAL HERNIA REPAIR?A COMPARISON OF CERTAIN COMPLICATIONS IN A CONTROLLED SERIES.
    JAMA, 1964, Oct-05, Volume: 190

    Topics: Anesthesia; Anesthesia, General; Anesthesia, Spinal; Bronchitis; Cyclopropanes; Ether; Halothane; He

1964
Comparison of the incidence of combined "risk factors" for gastric acid aspiration: influence of two anesthetic techniques.
    Anesthesia and analgesia, 1980, Volume: 59, Issue:11

    Topics: Anesthesia; Enflurane; Gastric Acid; Gastric Acidity Determination; Humans; Inhalation; Meperidine;

1980
[Advantages of combined alcohol anesthesia in emergency surgery on children with acute pneumonia].
    Vestnik khirurgii imeni I. I. Grekova, 1970, Volume: 104, Issue:6

    Topics: Adolescent; Anesthesia, Inhalation; Anesthesia, Intravenous; Appendicitis; Child; Child, Preschool;

1970