nitrous oxide has been researched along with Drug Withdrawal Symptoms in 54 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrous oxide gas (N2O) has been proposed to be effective in the treatment of the alcohol withdrawal syndrome (AWS)." | 2.70 | Long-term effects of and physiological responses to nitrous oxide gas treatment during alcohol withdrawal: a double-blind, placebo-controlled trial. ( Alho, H; Methuen, T; Paloheimo, M; Roine, R; Salaspuro, M; Seppä, K; Strid, N; Tiainen, J, 2002) |
| " The outcomes considered were alcohol withdrawal seizures, adverse events and dropouts." | 2.47 | Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. ( Amato, L; Davoli, M; Minozzi, S, 2011) |
| "One of the most severe consequences of alcohol dependence is the withdrawal syndrome, for which benzodiazepines are the most popular current treatment." | 2.44 | Psychotropic analgesic nitrous oxide for alcoholic withdrawal states. ( Gillman, MA; Lichtigfeld, FJ; Young, TN, 2007) |
| "The incidence of withdrawal convulsions was determined in mice following removal from a 70 per cent nitrous oxide environment." | 1.27 | The effect of naloxone and morphine on convulsions in mice following withdrawal from nitrous oxide. ( Dyke, G; Gough, M; Manson, HJ; Melling, J, 1983) |
| "These withdrawal seizure prone (WSP) and withdrawal seizure resistant (WSR) selection lines now differ by over 10-fold in HIC scores after equivalent exposure to intoxicating levels of ethanol via inhalation." | 1.27 | Ethanol and nitrous oxide produce withdrawal-induced convulsions by similar mechanisms in mice. ( Belknap, JK; Crabbe, JC; Laursen, SE, 1987) |
| "The severity and duration of these convulsions were related to the nitrous oxide concentration and duration of exposure." | 1.26 | Physical dependence on nitrous oxide in mice: resemblance to alcohol but not to opiate withdrawal. ( Cervenko, FW; Jhamandas, KH; Milne, B, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (35.19) | 18.7374 |
| 1990's | 18 (33.33) | 18.2507 |
| 2000's | 15 (27.78) | 29.6817 |
| 2010's | 2 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vengeliene, V | 1 |
| Bessiere, B | 1 |
| Pype, J | 1 |
| Spanagel, R | 1 |
| Gillman, MA | 25 |
| Amato, L | 1 |
| Minozzi, S | 1 |
| Davoli, M | 1 |
| Alho, H | 2 |
| Methuen, T | 2 |
| Paloheimo, M | 2 |
| Strid, N | 2 |
| Seppä, K | 2 |
| Tiainen, J | 2 |
| Salaspuro, M | 2 |
| Roine, R | 2 |
| Apter-Kaseva, N | 1 |
| Lichtigfeld, FJ | 22 |
| Diamond, I | 1 |
| Gillman, M | 1 |
| Lichtigfeld, F | 1 |
| Chick, J | 1 |
| Franck, J | 1 |
| Harker, N | 1 |
| Young, TN | 1 |
| Prince, V | 1 |
| Turpin, KR | 1 |
| Gilmann, MA | 1 |
| Manson, HJ | 1 |
| Dyke, G | 1 |
| Melling, J | 1 |
| Gough, M | 1 |
| Rupreht, J | 4 |
| Dworacek, B | 1 |
| Ducardus, R | 1 |
| Schmitz, PI | 1 |
| Dzoljic, MR | 4 |
| Sandyk, R | 1 |
| Harper, MH | 1 |
| Winter, PM | 3 |
| Johnson, BH | 1 |
| Koblin, DD | 1 |
| Eger, EI | 3 |
| Milne, B | 1 |
| Cervenko, FW | 1 |
| Jhamandas, KH | 1 |
| Vaughn, LK | 1 |
| Pruhs, RJ | 1 |
| Daynes, G | 3 |
| Ojutkangas, R | 2 |
| Dzoljic, M | 1 |
| Erdmann, W | 1 |
| Stijnen, TH | 1 |
| van Briemen, LJ | 1 |
| Brouette, T | 1 |
| Anton, R | 1 |
| Smith, RA | 2 |
| Smith, M | 2 |
| Myles, MJ | 1 |
| Ukponmwan, OE | 1 |
| Baas, AA | 1 |
| van den Berg, DJ | 1 |
| Dzoljic, MM | 2 |
| Haffmans, J | 1 |
| Adolfs, MJ | 1 |
| Cappendijk, SL | 1 |
| Carey, C | 1 |
| Clark, A | 1 |
| Saner, T | 1 |
| Dolin, SJ | 1 |
| Little, HJ | 1 |
| Newman, LM | 1 |
| Hoffman, WE | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 1 |
| Belknap, JK | 1 |
| Laursen, SE | 1 |
| Crabbe, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531] | Phase 4 | 210 participants (Anticipated) | Interventional | 2017-07-11 | Recruiting | ||
| Neurobiología Del Consumo de Substancias Psicoactivas: PET-CT- Inhalables[NCT02188914] | 70 participants (Actual) | Observational | 2014-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nitrous oxide and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome.
Topics: Alcohol Withdrawal Seizures; Alcoholism; Anticonvulsants; Baclofen; Benzodiazepines; Ethanol; Humans | 2011 |
Psychotropic analgesic nitrous oxide for alcoholic withdrawal states.
Topics: Alcoholic Beverages; Alcoholism; Analgesics, Non-Narcotic; Humans; Nitrous Oxide; Randomized Control | 2007 |
Treatment of alcohol withdrawal syndrome with carbamazepine, gabapentin, and nitrous oxide.
Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Ethan | 2008 |
Psychotropic analgesic nitrous oxide and neurotransmitter mechanisms involved in the alcohol withdrawal state.
Topics: Acetylcholine; Alcoholism; Epinephrine; Ethanol; gamma-Aminobutyric Acid; Glutamates; Humans; Neurot | 1994 |
Opioid properties of psychotropic analgesic nitrous oxide (laughing gas).
Topics: Analgesia; Animals; Humans; Naloxone; Nitrous Oxide; Receptors, Opioid; Receptors, Opioid, mu; Subst | 1994 |
Role of dopamine mesolimbic system in opioid action of psychotropic analgesic nitrous oxide in alcohol and drug withdrawal.
Topics: Analgesics, Non-Narcotic; Dopamine; Ethanol; Humans; Morphine; Nitrous Oxide; Nucleus Accumbens; Psy | 1996 |
Clinical review of inhalants.
Topics: Administration, Inhalation; Adolescent; Adolescent Behavior; Analgesics, Non-Narcotic; Child; Humans | 2001 |
7 trials available for nitrous oxide and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Long-term effects of and physiological responses to nitrous oxide gas treatment during alcohol withdrawal: a double-blind, placebo-controlled trial.
Topics: Alcoholism; Behavior, Addictive; Chi-Square Distribution; Double-Blind Method; Humans; Linear Models | 2002 |
Nitrous oxide has no effect in the treatment of alcohol withdrawal syndrome: a double-blind placebo-controlled randomized trial.
Topics: Adolescent; Adult; Double-Blind Method; Ethanol; Female; Humans; Male; Middle Aged; Nitrous Oxide; S | 2003 |
Enlarged double-blind randomised trial of benzodiazepines against psychotropic analgesic nitrous oxide for alcohol withdrawal.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Diazepam; Double-Blind Method; Drug Administration S | 2004 |
Combined cannabis/methaqualone withdrawal treated with psychotropic analgesic nitrous oxide.
Topics: Adult; Cannabis; Female; Humans; Hypnotics and Sedatives; Male; Methaqualone; Middle Aged; Nitrous O | 2006 |
Randomized double-blind trial of psychotropic analgesic nitrous oxide compared with diazepam for alcohol withdrawal state.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Anxiety Agents; Diazep | 2002 |
Opioid effects of analgesic (subanesthetic) nitrous oxide on the alcohol withdrawal state.
Topics: Alcoholism; Analgesics; Double-Blind Method; Humans; Nitrous Oxide; Placebos; Substance Withdrawal S | 1991 |
Analgesic nitrous oxide for alcohol withdrawal is better than placebo.
Topics: Adult; Double-Blind Method; Ethanol; Humans; Male; Middle Aged; Nitrous Oxide; Placebos; Randomized | 1989 |
40 other studies available for nitrous oxide and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
The effects of xenon and nitrous oxide gases on alcohol relapse.
Topics: Alcoholism; Anesthetics, Inhalation; Animals; Atmosphere Exposure Chambers; Conditioning, Operant; C | 2014 |
Psychotropic analgesic nitrous oxide for alcohol withdrawal.
Topics: Alcoholism; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Clinical Trials as Topic; Ethanol; Hu | 2008 |
Correct use of analgesic nitrous oxide for the alcohol withdrawal state is essential.
Topics: Alcoholism; Anesthetics, Inhalation; Ethanol; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 2004 |
Further comments on the effects of nitrous oxide treatment on alcohol withdrawal.
Topics: Alcoholism; Humans; Nitrous Oxide; Randomized Controlled Trials as Topic; Substance Withdrawal Syndr | 2004 |
Long-term effects of and physiological responses to nitrous oxide gas treatment during alcohol withdrawal: a double-blind, placebo-controlled trial.
Topics: Alcoholism; Double-Blind Method; Humans; Nitrous Oxide; Randomized Controlled Trials as Topic; Subst | 2004 |
An incorrect technique guarantees failure.
Topics: Alcoholism; Double-Blind Method; Humans; Nitrous Oxide; Randomized Controlled Trials as Topic; Resea | 2004 |
The nitrous oxide study: two points (expert response to Gillman/Alho letters to the editor).
Topics: Alcoholism; Double-Blind Method; Humans; Nitrous Oxide; Randomized Controlled Trials as Topic; Subst | 2004 |
Expert response to Gillman/Alho.
Topics: Alcoholism; Double-Blind Method; Humans; Nitrous Oxide; Randomized Controlled Trials as Topic; Subst | 2004 |
Nitrous oxide and treatment of withdrawal symptoms.
Topics: Alcoholism; Endorphins; Humans; Nitrous Oxide; Opioid-Related Disorders; Substance Withdrawal Syndro | 1980 |
The effect of naloxone and morphine on convulsions in mice following withdrawal from nitrous oxide.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; | 1983 |
The opiate and antiopiate system: evidence for involvement in withdrawal responses.
Topics: Animals; Humans; Nitrous Oxide; Rats; Receptors, Opioid; Substance Withdrawal Syndrome | 1983 |
The involvement of the central cholinergic and endorphinergic systems in the nitrous oxide withdrawal syndrome in mice.
Topics: Animals; Brain; Endorphins; Galantamine; Humans; Male; Mice; Naloxone; Nitrous Oxide; Parasympatheti | 1983 |
Subacute toxic delirium caused by nitrous oxide may be an acute withdrawal state.
Topics: Delirium; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1984 |
Management of alcohol withdrawal symptoms.
Topics: Ethanol; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1981 |
Withdrawal convulsions in mice following nitrous oxide.
Topics: Animals; Humans; Male; Mice; Mice, Inbred ICR; Nitrous Oxide; Partial Pressure; Seizures; Substance | 1980 |
Physical dependence on nitrous oxide in mice: resemblance to alcohol but not to opiate withdrawal.
Topics: Animals; Ethanol; Humans; Male; Mice; Naloxone; Nitrous Oxide; Opioid-Related Disorders; Seizures; S | 1981 |
Strain-dependent variability in nitrous oxide withdrawal seizure frequency.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nitrous Oxide; Seizures | 1995 |
The uses of analgesic nitrous oxide in neuropsychiatry.
Topics: Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1994 |
Nitrous oxide for alcohol withdrawal.
Topics: Ethanol; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1994 |
Psychotropic analgesic nitrous oxide prevents craving after withdrawal for alcohol, cannabis and tobacco.
Topics: Adolescent; Adult; Alcoholism; Ethanol; Female; Humans; Male; Marijuana Abuse; Middle Aged; Nitrous | 1994 |
Psychotropic analgesic nitrous oxide for treating alcohol withdrawal in an outpatient setting.
Topics: Adult; Aged; Alcoholism; Ambulatory Care; Ethanol; Female; Humans; Male; Middle Aged; Nitrous Oxide; | 1994 |
Behavioral and electrophysiological aspects of nitrous oxide dependence.
Topics: Animals; Behavior, Animal; Electrodes, Implanted; Electrophysiology; Evoked Potentials, Visual; Male | 1994 |
Alcohol withdrawal syndrome.
Topics: Ethanol; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1997 |
Convulsions in mice after anesthesia.
Topics: Anesthetics; Animals; Cyclopropanes; Ether; Ethers; Ethylenes; Humans; Methyldopa; Mice; Mice, Inbre | 1979 |
Tolerance to and dependence on inhalational anesthetics.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Cyclopropanes; Drug Tolerance; Humans; Isoflurane; Mic | 1979 |
Managing alcohol withdrawal states with oxygen and nitrous oxide.
Topics: Alcoholism; Humans; Nitrous Oxide; Oxygen Inhalation Therapy; Substance Withdrawal Syndrome | 1992 |
Suppressive effects of enkephalins and REM sleep deprivation on seizures.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; En | 1991 |
Analgesic nitrous oxide: rapid, safe therapy for addictive withdrawal.
Topics: Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1991 |
Decrease of beta-endorphin in the brain of rats following nitrous oxide withdrawal.
Topics: Animals; Atmosphere Exposure Chambers; Behavior, Animal; beta-Endorphin; Brain; Male; Nitrous Oxide; | 1991 |
Advances in understanding alcohol withdrawal states.
Topics: Ethanol; gamma-Aminobutyric Acid; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1991 |
Analgesic nitrous oxide for addictive withdrawal states in general practice.
Topics: Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1991 |
Analgesic nitrous oxide for alcohol withdrawal: a critical appraisal after 10 years' use.
Topics: Adult; Analgesia; Consciousness; Ethanol; Female; Humans; Male; Middle Aged; Nitrous Oxide; Substanc | 1990 |
Effects of "nitrendipine" on nitrous oxide anesthesia, tolerance, and physical dependence.
Topics: Anesthesia, Inhalation; Animals; Drug Tolerance; Male; Mice; Nitrendipine; Nitrous Oxide; Seizures; | 1989 |
The initial management of alcoholism using oxygen and nitrous oxide: a transcultural study.
Topics: Administration, Inhalation; Adult; Cross-Cultural Comparison; Ethanol; Female; Humans; Male; Middle | 1989 |
Analgesic nitrous oxide for addictive withdrawal states.
Topics: Ethanol; Humans; Nitrous Oxide; South Africa; Substance Withdrawal Syndrome | 1989 |
Regional blood flow and cerebral metabolic changes during alcohol withdrawal and following midazolam therapy.
Topics: Anesthesia, Inhalation; Animals; Benzodiazepines; Blood Gas Analysis; Blood Pressure; Brain; Ethanol | 1985 |
Ethanol and nitrous oxide produce withdrawal-induced convulsions by similar mechanisms in mice.
Topics: Animals; Ethanol; Handling, Psychological; Kinetics; Mice; Mice, Mutant Strains; Nitrous Oxide; Seiz | 1987 |
Minimal sedation required with nitrous oxide-oxygen treatment of the alcohol withdrawal state.
Topics: Adult; Ethanol; Humans; Hypnotics and Sedatives; Male; Nitrous Oxide; Prospective Studies; Substance | 1986 |
Anaesthesia and alcohol.
Topics: Anesthesia Recovery Period; Ethanol; Humans; Nitrous Oxide; Substance Withdrawal Syndrome | 1985 |
Analgesic nitrous oxide: adjunct to clonidine for opioid withdrawal.
Topics: Adult; Clonidine; Drug Therapy, Combination; Female; Humans; Meperidine; Morphine; Morphine Dependen | 1985 |