nitrous oxide has been researched along with Depression in 15 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood." | 9.69 | Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG. ( Hu, B; Kong, W; Li, L; Li, X; Liao, M; Ou, W; Shao, X; Sun, S; Yan, D; Zhang, Y; Zheng, F, 2023) |
| "Nitrous oxide at 50% inhaled concentration has been shown to improve depressive symptoms in patients with treatment-resistant major depression (TRMD)." | 9.41 | A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. ( Barnes, L; Bolzenius, JD; Brown, F; Cheng, WWL; Conway, CR; Espejo, GD; Gibbons, R; Gott, B; Jain, N; Janski, A; Komen, H; Lessov-Schlaggar, CN; Nagele, P; Nguyen, T; Palanca, BJ; Salloum, NC; Xiong, W; Yee, B; Zorumski, CF, 2021) |
| "Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood." | 5.69 | Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG. ( Hu, B; Kong, W; Li, L; Li, X; Liao, M; Ou, W; Shao, X; Sun, S; Yan, D; Zhang, Y; Zheng, F, 2023) |
| "Nitrous oxide at 50% inhaled concentration has been shown to improve depressive symptoms in patients with treatment-resistant major depression (TRMD)." | 5.41 | A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. ( Barnes, L; Bolzenius, JD; Brown, F; Cheng, WWL; Conway, CR; Espejo, GD; Gibbons, R; Gott, B; Jain, N; Janski, A; Komen, H; Lessov-Schlaggar, CN; Nagele, P; Nguyen, T; Palanca, BJ; Salloum, NC; Xiong, W; Yee, B; Zorumski, CF, 2021) |
| "Nitrous oxide (N2O) is an anesthetic gas with both therapeutic and abuse potential." | 1.62 | Rewarding Subjective Effects of the NMDAR Antagonist Nitrous Oxide (Laughing Gas) Are Moderated by Impulsivity and Depressive Symptoms in Healthy Volunteers. ( Cawley, E; Das, RK; Hennessy, V; Iskandar, G; Kamboj, SK; Piazza, G; Troebinger, L; Zhao, H, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 6 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quach, DF | 1 |
| de Leon, VC | 2 |
| Conway, CR | 4 |
| Shao, X | 1 |
| Yan, D | 1 |
| Kong, W | 1 |
| Sun, S | 1 |
| Liao, M | 1 |
| Ou, W | 1 |
| Zhang, Y | 1 |
| Zheng, F | 1 |
| Li, X | 1 |
| Li, L | 1 |
| Hu, B | 1 |
| Kumar, A | 1 |
| Nagele, P | 3 |
| Palanca, BJ | 2 |
| Gott, B | 2 |
| Janski, A | 3 |
| Zorumski, CF | 3 |
| Kamboj, SK | 2 |
| Zhao, H | 1 |
| Troebinger, L | 1 |
| Piazza, G | 1 |
| Cawley, E | 1 |
| Hennessy, V | 1 |
| Iskandar, G | 1 |
| Das, RK | 2 |
| Kohtala, S | 1 |
| Rantamäki, T | 1 |
| Brown, F | 1 |
| Barnes, L | 1 |
| Nguyen, T | 1 |
| Xiong, W | 1 |
| Salloum, NC | 1 |
| Espejo, GD | 1 |
| Lessov-Schlaggar, CN | 1 |
| Jain, N | 1 |
| Cheng, WWL | 1 |
| Komen, H | 1 |
| Yee, B | 1 |
| Bolzenius, JD | 1 |
| Gibbons, R | 1 |
| Duma, A | 1 |
| Kopec, M | 1 |
| Gebara, MA | 1 |
| Parsoei, A | 1 |
| Walker, M | 1 |
| Panagopoulos, VN | 1 |
| Cristancho, P | 1 |
| Miller, JP | 1 |
| Liang, Y | 1 |
| Yang, X | 1 |
| Zhang, X | 1 |
| Duan, H | 1 |
| Jin, M | 1 |
| Sun, Y | 1 |
| Yuan, H | 1 |
| Li, J | 1 |
| Qi, Y | 1 |
| Qiao, W | 1 |
| Walsh, K | 1 |
| LASSEN, HC | 1 |
| HENRIKSEN, E | 1 |
| NEUKIRCH, F | 1 |
| KRISTENSEN, HS | 1 |
| Turek, IS | 1 |
| Hanlon, TE | 1 |
| Lebedinskiĭ, MS | 1 |
| Bortnik, TL | 1 |
| Zel'man, VL | 1 |
| Kalandarishvili, AS | 1 |
| Ostrovskiĭ, BI | 1 |
| Lader, M | 1 |
| Lader, MH | 1 |
| Gravenstein, JS | 1 |
| Anton, AH | 1 |
| Wiener, SM | 1 |
| Tetlow, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011] | Phase 4 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -1.8 |
| Nitrous Oxide | -2.5 |
"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Somewhat improved, -1 | No change, 0 | Somewhat worsened, 1 | Significantly worsened, 2 | |
| Nitrous Oxide | 2 | 34 | 2 | 0 |
| Placebo | 5 | 28 | 5 | 1 |
5 reviews available for nitrous oxide and Depression
| Article | Year |
|---|---|
Nitrous Oxide: an emerging novel treatment for treatment-resistant depression.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Resist | 2022 |
Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia.
Topics: Anesthesia; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Depr | 2021 |
The effectiveness and safety of electroconvulsive therapy (ECT).
Topics: Acute Disease; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Chronic Disease; Clinica | 1977 |
Research report: Institute of Psychiatry Clinical Psychopharmacology Research Team.
Topics: Antidepressive Agents; Anxiety; Barbiturates; Conversion Disorder; Depression; Drug Combinations; Dr | 1974 |
Physiological measures in psychiatry.
Topics: Adaptation, Psychological; Amobarbital; Animals; Anxiety; Arousal; Blood Pressure; Depression; Elect | 1971 |
4 trials available for nitrous oxide and Depression
| Article | Year |
|---|---|
Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG.
Topics: Antidepressive Agents; Brain; Depression; Depressive Disorder, Treatment-Resistant; Electroencephalo | 2023 |
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Double-Blind Method; Humans; Nitrous | 2021 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
The effectiveness and safety of electroconvulsive therapy (ECT).
Topics: Acute Disease; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Chronic Disease; Clinica | 1977 |
7 other studies available for nitrous oxide and Depression
| Article | Year |
|---|---|
Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis.
Topics: Depression; Depressive Disorder, Major; Humans; Ketamine; Nitrous Oxide; Suicidal Ideation | 2023 |
Rewarding Subjective Effects of the NMDAR Antagonist Nitrous Oxide (Laughing Gas) Are Moderated by Impulsivity and Depressive Symptoms in Healthy Volunteers.
Topics: Adult; Depression; Excitatory Amino Acid Antagonists; Female; Healthy Volunteers; Humans; Impulsive | 2021 |
Antidepressant-like effect of the saponins part of ethanol extract from SHF.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain; Catalase; Depression; Disease | 2016 |
The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers.
Topics: Adolescent; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Anxiety; Craving; Depression; Endophe | 2017 |
Treatment of tetanus; severe bone-marrow depression after prolonged nitrous-oxide anaesthesia.
Topics: Anemia; Anemia, Aplastic; Anesthesia; Anesthesiology; Bone Marrow; Child; Depression; Humans; Infant | 1956 |
[Several psychotherapeutic and anesthesiologic aspects of using nitrous oxide in the clinical picture of borderline states].
Topics: Adult; Anesthesia, General; Depression; Female; Humans; Hypochondriasis; Male; Mental Disorders; Mid | 1976 |
Catecholamine and cardiovascular response to electro-convulsion therapy in man.
Topics: Anesthesia, General; Blood Pressure; Depression; Electroconvulsive Therapy; Epinephrine; Halothane; | 1965 |