nitrous oxide has been researched along with Depression, Involutional in 13 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrous oxide at 50% inhaled concentration has been shown to improve depressive symptoms in patients with treatment-resistant major depression (TRMD)." | 9.41 | A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. ( Barnes, L; Bolzenius, JD; Brown, F; Cheng, WWL; Conway, CR; Espejo, GD; Gibbons, R; Gott, B; Jain, N; Janski, A; Komen, H; Lessov-Schlaggar, CN; Nagele, P; Nguyen, T; Palanca, BJ; Salloum, NC; Xiong, W; Yee, B; Zorumski, CF, 2021) |
| "Nitrous oxide at 50% inhaled concentration has been shown to improve depressive symptoms in patients with treatment-resistant major depression (TRMD)." | 5.41 | A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. ( Barnes, L; Bolzenius, JD; Brown, F; Cheng, WWL; Conway, CR; Espejo, GD; Gibbons, R; Gott, B; Jain, N; Janski, A; Komen, H; Lessov-Schlaggar, CN; Nagele, P; Nguyen, T; Palanca, BJ; Salloum, NC; Xiong, W; Yee, B; Zorumski, CF, 2021) |
| "Multiple illicit substance users were more likely to use methamphetamine (p = 0." | 1.72 | Survey of substance use among adolescent drug offenders referred from juvenile courts in Taiwan: Clinical epidemiology of single versus multiple illicit substance use. ( Chen, LY; Chen, MH; Chen, YH; Wei, HT, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 7 (53.85) | 2.80 |
| Authors | Studies |
|---|---|
| Quach, DF | 1 |
| de Leon, VC | 2 |
| Conway, CR | 4 |
| Liu, H | 1 |
| Kerzner, J | 1 |
| Demchenko, I | 1 |
| Wijeysundera, DN | 1 |
| Kennedy, SH | 1 |
| Ladha, KS | 1 |
| Bhat, V | 1 |
| Chen, YH | 1 |
| Chen, MH | 1 |
| Wei, HT | 1 |
| Chen, LY | 1 |
| Kumar, A | 1 |
| Nagele, P | 4 |
| Palanca, BJ | 2 |
| Gott, B | 2 |
| Janski, A | 3 |
| Zorumski, CF | 3 |
| Qiu, Y | 1 |
| Li, L | 1 |
| Duan, A | 1 |
| Wang, M | 1 |
| Xie, M | 1 |
| Chen, Z | 1 |
| Wang, Z | 1 |
| Lee, K | 1 |
| Sparkle, T | 1 |
| Brown, F | 1 |
| Barnes, L | 1 |
| Nguyen, T | 1 |
| Xiong, W | 1 |
| Salloum, NC | 1 |
| Espejo, GD | 1 |
| Lessov-Schlaggar, CN | 1 |
| Jain, N | 1 |
| Cheng, WWL | 1 |
| Komen, H | 1 |
| Yee, B | 1 |
| Bolzenius, JD | 1 |
| Gibbons, R | 1 |
| Stewart, RM | 1 |
| Wong, JWY | 1 |
| Runions, KC | 1 |
| Rao, P | 1 |
| Moore, JK | 1 |
| Davies, SR | 1 |
| von Ungern-Sternberg, BS | 1 |
| Sommerfield, D | 1 |
| Zepf, FD | 1 |
| Buhre, W | 1 |
| Disma, N | 1 |
| Hendrickx, J | 1 |
| DeHert, S | 1 |
| Hollmann, MW | 1 |
| Huhn, R | 1 |
| Jakobsson, J | 1 |
| Peyton, P | 1 |
| Vutskits, L | 1 |
| Duma, A | 1 |
| Kopec, M | 1 |
| Gebara, MA | 1 |
| Parsoei, A | 1 |
| Walker, M | 1 |
| Panagopoulos, VN | 1 |
| Cristancho, P | 1 |
| Miller, JP | 1 |
| Zarate, CA | 1 |
| Machado-Vieira, R | 1 |
| Martin, RF | 1 |
| Desai, SP | 1 |
| Levine, J | 1 |
| Chengappa, KN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011] | Phase 4 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -1.8 |
| Nitrous Oxide | -2.5 |
"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Somewhat improved, -1 | No change, 0 | Somewhat worsened, 1 | Significantly worsened, 2 | |
| Nitrous Oxide | 2 | 34 | 2 | 0 |
| Placebo | 5 | 28 | 5 | 1 |
5 reviews available for nitrous oxide and Depression, Involutional
| Article | Year |
|---|---|
Nitrous Oxide: an emerging novel treatment for treatment-resistant depression.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Resist | 2022 |
Nitrous oxide for the treatment of psychiatric disorders: A systematic review of the clinical trial landscape.
Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Nitrous Oxide; Stress Disorders, Post-Traumati | 2022 |
The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis.
Topics: Depressive Disorder, Major; Humans; Nausea; Nitrous Oxide; Vomiting | 2023 |
European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice.
Topics: Analgesia, Obstetrical; Analgesics, Non-Narcotic; Anesthesia, Dental; Anesthetics, Inhalation; Antid | 2019 |
An Examination of Horace Wells' Life as a Manifestation of Major Depressive and Seasonal Affective Disorders.
Topics: Anesthetics, Inhalation; Bipolar Disorder; Chloroform; Connecticut; Dentistry; Depressive Disorder, | 2016 |
3 trials available for nitrous oxide and Depression, Involutional
| Article | Year |
|---|---|
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Double-Blind Method; Humans; Nitrous | 2021 |
Nitrous oxide (N
Topics: Adolescent; Child; Data Interpretation, Statistical; Depressive Disorder, Major; Drug Therapy, Combi | 2017 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Topics: Adult; Antidepressive Agents; Cross-Over Studies; Depression; Depressive Disorder, Major; Depressive | 2015 |
5 other studies available for nitrous oxide and Depression, Involutional
| Article | Year |
|---|---|
Survey of substance use among adolescent drug offenders referred from juvenile courts in Taiwan: Clinical epidemiology of single versus multiple illicit substance use.
Topics: Adolescent; Criminals; Depressive Disorder, Major; Humans; Illicit Drugs; Ketamine; Methamphetamine; | 2022 |
Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis.
Topics: Depression; Depressive Disorder, Major; Humans; Ketamine; Nitrous Oxide; Suicidal Ideation | 2023 |
Use of Nitrous Oxide to Facilitate Induction for Electroconvulsive Therapy: A Case Report.
Topics: Anesthetics, Intravenous; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Humans; Met | 2020 |
Potential Pathways Involved in the Rapid Antidepressant Effects of Nitrous Oxide.
Topics: Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; | 2015 |
Exposure to nitrous oxide may be associated with high homocysteine plasma levels and a risk for clinical depression.
Topics: Adult; Anesthetics, Inhalation; Dentists, Women; Depressive Disorder, Major; Diagnostic and Statisti | 2007 |