Page last updated: 2024-10-19

nitrous oxide and Demyelinating Diseases

nitrous oxide has been researched along with Demyelinating Diseases in 16 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

Research Excerpts

ExcerptRelevanceReference
"Nitrous oxide (N₂O) toxicity can result in myelin loss and hyperhomocysteinemia similar to cobalamin (Cbl) deficiency."3.81Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress. ( Bora, HK; Kalita, J; Misra, UK; Murthy, RC; Singh, SK, 2015)
"Nitrous oxide is known to inactivate vitamin B12 via oxidation, which can precipitate a demyelinating myelopathy akin to the classical B12 deficiency syndrome, subacute combined degeneration of the spinal cord."1.43An unusual cause of falls in a young woman. ( Burn, D; Sleeman, I; Wiblin, L, 2016)
"The basic cause is vitamin B12 deficiency and the irreversible oxidation of coenzyme B12 by N2O."1.29[N2O-induced acute funicular myelosis in latent vitamin B 12 deficiency]. ( Takács, J, 1996)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's3 (18.75)18.2507
2000's3 (18.75)29.6817
2010's7 (43.75)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Blair, C1
Tremonti, C1
Edwards, L1
Haber, PS1
Halmagyi, GM1
Noh, T1
Osman, G1
Chedid, M1
Hefzy, H1
Walker, S1
Marshall, J1
Ginsberg, L1
Singh, SK1
Misra, UK1
Kalita, J1
Bora, HK1
Murthy, RC1
Duque, MA1
Kresak, JL1
Falchook, A1
Harris, NS1
Massey, TH1
Pickersgill, TT1
J Peall, K1
Sleeman, I1
Wiblin, L1
Burn, D1
Alt, RS1
Morrissey, RP1
Gang, MA1
Hoffman, RS1
Schaumburg, HH1
Waclawik, AJ1
Luzzio, CC1
Juhasz-Pocsine, K1
Hamilton, V1
Scott, JM1
Dinn, JJ1
Wilson, P1
Weir, DG1
Takács, J1
Sesso, RM1
Iunes, Y1
Melo, AC1
Marié, RM1
Le Biez, E1
Busson, P1
Schaeffer, S1
Boiteau, L1
Dupuy, B1
Viader, F1
Vinciguerra, C1
Chazerain, P1
Olivero de Rubiana, JP1
Moulonguet, A1
Ziza, JM1
Duffield, MS1
Phillips, JI1
Vieira-Makings, E1
Van der Westhuyzen, J1
Metz, J1
Shimizu, T1
Nishimura, Y1
Fujishima, Y1
Miyajima, H1
Honda, N1

Reviews

2 reviews available for nitrous oxide and Demyelinating Diseases

ArticleYear
[Postoperative combined medullary sclerosis revealing Biermer's disease: toxic effect of nitrous oxide].
    Revue neurologique, 2000, Volume: 156, Issue:6-7

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Abscess; Aged; Anemia, Pernicious; Anesth

2000
[Subacute myeloneuropathy after abuse of nitrous oxide: an electron microscopic study on the peripheral nerve].
    Rinsho shinkeigaku = Clinical neurology, 1989, Volume: 29, Issue:9

    Topics: Adult; Demyelinating Diseases; Humans; Male; Microscopy, Electron; Nitrous Oxide; Peripheral Nervous

1989

Other Studies

14 other studies available for nitrous oxide and Demyelinating Diseases

ArticleYear
Vitamin B
    The Medical journal of Australia, 2019, Volume: 211, Issue:9

    Topics: Adult; Anesthetics, Inhalation; Ataxia; Demyelinating Diseases; Female; Humans; Inhalant Abuse; Magn

2019
Nitrous oxide-induced demyelination: Clinical presentation, diagnosis and treatment recommendations.
    Journal of the neurological sciences, 2020, Jul-15, Volume: 414

    Topics: Demyelinating Diseases; Humans; Injections, Intramuscular; Nitrous Oxide; Vitamin B 12; Vitamin B 12

2020
No laughing matter.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2017, Volume: 67, Issue:659

    Topics: Anesthetics, Inhalation; Demyelinating Diseases; Humans; Nitrous Oxide; Substance-Related Disorders;

2017
Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress.
    Neurotoxicology, 2015, Volume: 48

    Topics: Animals; Antioxidants; Behavior, Animal; Brain; Demyelinating Diseases; Disease Models, Animal; Glut

2015
Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report.
    Laboratory medicine, 2015,Fall, Volume: 46, Issue:4

    Topics: Adult; Demyelinating Diseases; Female; Humans; Methylmalonic Acid; Nitrous Oxide; Paresthesia; Spina

2015
Nitrous oxide misuse and vitamin B12 deficiency.
    BMJ case reports, 2016, May-31, Volume: 2016

    Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Humans; Magnetic Re

2016
An unusual cause of falls in a young woman.
    The journal of the Royal College of Physicians of Edinburgh, 2016, Volume: 46, Issue:3

    Topics: Accidental Falls; Adult; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Chronic Pain; Demyelinat

2016
Severe myeloneuropathy from acute high-dose nitrous oxide (N2O) abuse.
    The Journal of emergency medicine, 2011, Volume: 41, Issue:4

    Topics: Anesthetics, Inhalation; Demyelinating Diseases; Humans; Male; Nitrous Oxide; Vitamin B 12 Deficienc

2011
Myeloneuropathy from nitrous oxide abuse: unusually high methylmalonic acid and homocysteine levels.
    WMJ : official publication of the State Medical Society of Wisconsin, 2003, Volume: 102, Issue:4

    Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Homocysteine; Human

2003
Pathogenesis of subacute combined degeneration: a result of methyl group deficiency.
    Lancet (London, England), 1981, Aug-15, Volume: 2, Issue:8242

    Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Humans; Macaca fascicularis; Methionine; Ni

1981
[N2O-induced acute funicular myelosis in latent vitamin B 12 deficiency].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1996, Volume: 31, Issue:8

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Demyelinating Diseases; Erythrocyte Indices; Female

1996
Myeloneuropathy following nitrous oxide anesthaesia in a patient with macrocytic anaemia.
    Neuroradiology, 1999, Volume: 41, Issue:8

    Topics: Anemia, Macrocytic; Anesthetics, Inhalation; Demyelinating Diseases; Female; Humans; Magnetic Resona

1999
Nitrous oxide anesthesia-associated myelopathy.
    Archives of neurology, 2000, Volume: 57, Issue:3

    Topics: Adenoma; Aged; Anemia, Pernicious; Anesthetics, Inhalation; Demyelinating Diseases; Humans; Magnetic

2000
Demyelinisation in the spinal cord of vitamin B12 deficient fruit bats.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1990, Volume: 96, Issue:2

    Topics: Animals; Chiroptera; Demyelinating Diseases; Microscopy, Electron; Nitrous Oxide; Spinal Cord Diseas

1990