nitrous oxide has been researched along with Degenerative Diseases, Central Nervous System in 3 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keddie, S | 1 |
| Adams, A | 1 |
| Kelso, ARC | 1 |
| Turner, B | 1 |
| Schmierer, K | 1 |
| Gnanapavan, S | 1 |
| Malaspina, A | 1 |
| Giovannoni, G | 1 |
| Basnett, I | 1 |
| Noyce, AJ | 1 |
| Francis, A | 1 |
| Crossley, R | 1 |
| Brady, S | 1 |
| Jevtovic-Todorovic, V | 1 |
| Hartman, RE | 1 |
| Izumi, Y | 1 |
| Benshoff, ND | 1 |
| Dikranian, K | 1 |
| Zorumski, CF | 1 |
| Olney, JW | 1 |
| Wozniak, DF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853] | 16 participants (Anticipated) | Interventional | 2023-07-31 | Not yet recruiting | |||
| Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764] | 369 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial[NCT02559102] | Phase 3 | 104 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Randomized Controlled Trial of Nitrous Oxide Analgesia in External Cephalic Version (ECV)[NCT03502915] | Phase 3 | 48 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study[NCT05759351] | 30 participants (Actual) | Observational | 2006-01-01 | Completed | |||
| A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514] | 30 participants (Actual) | Observational | 2008-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anxiety scores will be collected following each version attempt using an 11 point scale (0 being not at all anxious; 10 being extremely anxious), ranging from 0 to 10. Higher scores indicate more anxiety, lower scores indicate less anxiety. If more than one attempt, anxiety scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.696 |
| Oxygen | 4.253 |
Pain scores will be collected following each version attempt using an 11 point scale (with 0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. If more than one attempt, pain scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 5.486 |
| Oxygen | 5.433 |
Pain scores will be collected following completion of the version using an 11 point scale (0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 1 |
| Oxygen | 0.88 |
Satisfaction will be assessed following the procedure using an 11 point scale (0 being not at all satisfied; 10 being extremely satisfied), ranging from 0 to 10. Higher scores indicate more satisfaction, lower scores indicate less satisfaction. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.286 |
| Oxygen | 6.920 |
Following the procedure, the obstetric provider performing the procedure will rate the ease of procedure on a 1-10 scale (1 being very easy and 10 being extremely difficult), ranging from 1 to 10. Higher scores indicate more difficulty, lower scores indicate less difficulty. A 10 point scale was used for this outcome, while an 11 point scale was used for the other 4 outcome measures (pain, anxiety, post-procedure pain and satisfaction). (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 6.136 |
| Oxygen | 6.080 |
3 other studies available for nitrous oxide and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation.
Topics: Adolescent; Adult; Ataxia; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Male | 2018 |
Subacute progressive sensorimotor symptoms.
Topics: Adult; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseas | 2019 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |