nitrous oxide has been researched along with Deficiency, Vitamin B 12 in 165 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Use of nitrous oxide in pediatric leukemia patients at the same time as methotrexate use should be avoided especially as many suitable alternative anesthetic agents exist." | 7.83 | Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. ( Baird, SF; Forster, VJ; Halsey, C; Mair, S; Skinner, R; van Delft, FW, 2016) |
| "Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia." | 6.38 | Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. ( Flippo, TS; Holder, WD, 1993) |
| "Imaging revealed extensive cerebral thrombosis." | 5.72 | Extensive Cerebral Venous Thrombosis Secondary to Recreational Nitrous Oxide Abuse. ( Farhat, W; Mijahed, R; Pariente, A, 2022) |
| "N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi." | 5.62 | [Thromboembolisms due to recreational use of nitrous oxide]. ( de Metz, J; Fokkema, TMM; Kuipers, RS; Oomens, T; Riezebos, RK; van den Bogaard, B; van Nieuwenhuizen, RC, 2021) |
| "A 27-year-old woman presented with confusion, agitation and fever." | 5.51 | Encephalitis secondary to nitrous oxide and vitamin B ( Dedicoat, MJ; Hughes, G; Moran, E, 2019) |
| "In patients with postsurgical myelopathy, surgeons should evaluate B12 status and consider the possibility that nitrous oxide could cause a subclinical B12 deficiency to become overt, particularly in patients with malabsorptive GI comorbidities." | 4.98 | Subacute combined degeneration of the spinal cord following nitrous oxide anesthesia: A systematic review of cases. ( Alshafai, N; Cheng, J; Gimbel, D; Gunness, VRN; Hersey, D; Mejia Munne, JC; Nasser, R; Nouri, A; Patel, KK; Sciubba, D, 2018) |
| "We present a case of non-immune haemolytic anaemia with leukopenia and acute severe neurological impairments, as a result of severe vitamin B12 deficiency due to recreational use of nitrous oxide." | 3.85 | Is nitrous oxide really that joyful? ( Ertekin, E; Glijn, NHP; Grimbergen, YAM; Libourel, EJ; van Burg, PLM; van der Linde, D, 2017) |
| "Use of nitrous oxide in pediatric leukemia patients at the same time as methotrexate use should be avoided especially as many suitable alternative anesthetic agents exist." | 3.83 | Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. ( Baird, SF; Forster, VJ; Halsey, C; Mair, S; Skinner, R; van Delft, FW, 2016) |
| "Nitrous oxide (N₂O) toxicity can result in myelin loss and hyperhomocysteinemia similar to cobalamin (Cbl) deficiency." | 3.81 | Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress. ( Bora, HK; Kalita, J; Misra, UK; Murthy, RC; Singh, SK, 2015) |
| " However, persisting neurological signs despite adequate treatment lately led to diagnose subacute combined medullar degeneration due to abnormal cobalamin (vitamin B12) metabolism induced by repeated use of nitrous oxide during painful episodes of sickle-cell disease." | 3.80 | [Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration]. ( Cabral, D; Chaugny, C; Collin-Masson, H; De Beauchêne, M; Fagniez, O; Simon, J; Veyssier-Belot, C, 2014) |
| "We report on a diabetic man in his early forties with a history of disabling left-hemisphere stroke and hyperhomocystinemia who developed new sensorimotor symptoms and urinary incontinence 4 weeks after prolonged exposure to nitrous oxide (N(2)O) related to arterial occlusive disease and amputation." | 3.73 | Cobalamin deficiency and subacute combined degeneration after nitrous oxide anesthesia: a case report. ( Ahn, SC; Brown, AW, 2005) |
| "After exposure to nitrous oxide, an infant with unrecognized cobalamin deficiency developed neurologic deterioration and pancytopenia." | 3.70 | Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide. ( Felmet, K; Hayflick, SJ; Robins, B; Tilford, D, 2000) |
| " Nitrous oxide (N2O), which inactivates vitamin B-12 in vivo, results in neurological impairment leading to ataxia and death in the fruit bat Rousettus ." | 3.67 | Betaine delays the onset of neurological impairment in nitrous oxide-induced vitamin B-12 deficiency in fruit bats. ( Metz, J; van der Westhuyzen, J, 1984) |
| "Nitrous oxide (NO) is a commonly used drug in medical practice, restoration, and the automobile industry." | 2.82 | Peripheral polyneuropathy and acute psychosis from chronic nitrous oxide poisoning: A case report with literature review. ( Parent, T; Sood, R, 2022) |
| "Nitrous oxide is an increasingly popular recreational drug." | 2.72 | Nitrous oxide-induced neurotoxicity: A case report and literature review. ( Burrage, D; Thayabaran, D, 2021) |
| "Nitrous oxide anaesthesia is a particular risk." | 2.47 | Vitamin B12 deficiency and phenylketonuria. ( Walter, JH, 2011) |
| "It is known to precipitate vitamin B12 deficiency when used chronically and acutely, especially in people having marginal vitamin B12 reserve." | 2.43 | Nitrous oxide "whippit" abuse presenting with cobalamin responsive psychosis. ( Capasso, G; Mullin, P; Sethi, NK; Torgovnick, J, 2006) |
| "As vitamin B12 deficiency is caused by malabsorption in the gastrointestinal tract, oral supplementation is insufficient." | 2.41 | [Subacute combined degeneration of the spinal cord: easy diagnosis, effective treatment]. ( Franke, CL; Jongen, JC; Koehler, PJ, 2001) |
| "Nitrous oxide may cause neurological and haematological signs and symptoms, as a result of its tendency to form complex with cobalt(I) in methylcobalamin, the cofactor for methionine synthase (EC 2." | 2.40 | [Nitrous oxide can cause cobalamin deficiency. Vitamin B12 is a simple and cheap remedy]. ( Lindstedt, G, 1999) |
| "N2O is a relatively safe general anaesthetic under normal medical and dental anaesthetic use." | 2.39 | Myelotoxic, neurotoxic and reproductive adverse effects of nitrous oxide. ( Louis-Ferdinand, RT, 1994) |
| "Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia." | 2.38 | Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. ( Flippo, TS; Holder, WD, 1993) |
| "A vitamin B12 deficiency is unusual in pregnant women who consume a normal, varied diet." | 2.37 | Clinical chemistry of vitamin B12. ( Davis, RE, 1985) |
| "Risk factors for vitamin B12 deficiency in infants are not fully understood." | 1.72 | Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency. ( Bjørke-Monsen, AL; Eklund, EA; Lindberg, M; Ljungblad, UW; Saeves, I; Tangeraas, T, 2022) |
| "Imaging revealed extensive cerebral thrombosis." | 1.72 | Extensive Cerebral Venous Thrombosis Secondary to Recreational Nitrous Oxide Abuse. ( Farhat, W; Mijahed, R; Pariente, A, 2022) |
| "Of the 85 cases with vitamin B12 deficiency, 80% presented with spells (37%) of apneas, motor seizures, or absences within the first two months of life." | 1.72 | Breastfed Infants With Spells, Tremor, or Irritability: Rule Out Vitamin B12 Deficiency. ( Astrup, H; Bjørke-Monsen, AL; Eklund, EA; Hager, HB; Lindberg, M; Ljungblad, UW; Mørkrid, L; Rootwelt, T; Tangeraas, T, 2022) |
| "We report four cases of subacute combined degeneration induced by recreational nitrous oxide abuse despite self-administered vitamin B12 supplementation." | 1.72 | Nitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation. ( Horowitz, BZ; Temple, C, 2022) |
| "N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi." | 1.62 | [Thromboembolisms due to recreational use of nitrous oxide]. ( de Metz, J; Fokkema, TMM; Kuipers, RS; Oomens, T; Riezebos, RK; van den Bogaard, B; van Nieuwenhuizen, RC, 2021) |
| "Nitrous oxide misuse is a recognized issue worldwide." | 1.62 | Nitrous oxide-induced myeloneuropathy. ( Barnes, S; Blair, C; Bolitho, S; Cremer, P; Lu, Z; Michael Halmagyi, G; Offord, J; Palavra, N; Sutherland, E; Swart, G; Yogendran, S, 2021) |
| "Nitrous oxide (NO) is an inhalant that has become increasingly popular as a recreational drug." | 1.62 | Cerebral venous sinus thrombosis: a complication of nitrous oxide abuse. ( Bouwman, NAMG; de Valck, L; Defelippe, VM, 2021) |
| "A 27-year-old woman presented with confusion, agitation and fever." | 1.51 | Encephalitis secondary to nitrous oxide and vitamin B ( Dedicoat, MJ; Hughes, G; Moran, E, 2019) |
| "Vitamin B12 deficiency was found in the first patient as well as signs of myelopathy on magnetic resonance imaging, and the second patient had acute liver injury." | 1.51 | [Acute neuropathy and liver injury following the abuse of nitrous oxide]. ( Bøgevig, S; Gullestrup, A; Jensen, RB; Nilsson, PM, 2019) |
| "Neurological evaluation confirmed vitamin B12 deficiency consistent with the toxic effects of nitrous oxide." | 1.48 | Peripheral Neuropathy Due to Recreational Use of Nitrous Oxide Presenting After an Ankle Sprain With Foot Drop. ( Middleton, JA; Roffers, JA, 2018) |
| "Hence, vitamin B12 deficiency can lead to degeneration of the dorsal and lateral columns of the spinal cord." | 1.46 | [Nitrous oxide-induced polyneuropathy]. ( Beekman, R; Beerhorst, K; Bruijnes, JE; Conjaerts, SHP, 2017) |
| "She developed a progressive subacute myelopathy with a sensory level, profoundly impaired joint position sense, extensor plantars and required a wheelchair." | 1.43 | An unusual cause of falls in a young woman. ( Burn, D; Sleeman, I; Wiblin, L, 2016) |
| "A case of subacute combined degeneration (SCD) of the spinal cord manifesting as severe ataxia and urinary retention in a patient with a history of heavy nitrous oxide abuse and self-supplementation with cyanocobalamin is reported." | 1.42 | Subacute combined degeneration of the spinal cord in a patient abusing nitrous oxide and self-medicating with cyanocobalamin. ( Ambrose, TM; Neuburger, KJ; Oettinger, GR; Pugliese, RS; Slagle, EJ, 2015) |
| "We describe a patient with a typical vitamin B12 deficiency syndrome after N2 O abuse who recovered and then developed a severe lower motor neuron syndrome following vitamin B12 correction." | 1.42 | Severe motor neuropathy or neuronopathy due to nitrous oxide toxicity after correction of vitamin B12 deficiency. ( Greenberg, SA; Lynch, K; Morris, N, 2015) |
| "This case discusses subacute combined degeneration of the spinal cord on a background of N2O abuse." | 1.39 | Subacute combined degeneration of the spinal cord following recreational nitrous oxide use. ( Cheng, HM; Hernstadt, D; Park, JH, 2013) |
| "Copper deficiency myelopathy (CDM) is an increasingly recognised mimic of subacute combined degeneration (SCD) of the cord due to cobalamin (vitamin B(12)) deficiency." | 1.35 | Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar? ( Jaiser, SR; Winston, GP, 2008) |
| "Nitrous oxide toxicity has been reported in medical and dental professions and a few cases of myeloneuropathy due to induced vitamin B12 deficiency have been reported." | 1.30 | Myeloneuropathy from whipped cream bulbs presenting as conversion disorder. ( Brett, A, 1997) |
| "2." | 1.29 | [N2O-induced acute funicular myelosis in latent vitamin B 12 deficiency]. ( Takács, J, 1996) |
| "Pigs treated with nitrous oxide for periods of 1, 2 and 4 months demonstrated markedly reduced levels of methionine synthase and concomitant reduction in the ratio of S-adenosylmethionine to S-adenosylhomocysteine, the methylation ratio, at all time intervals." | 1.29 | Demonstration of hypomethylation of proteins in the brain of pigs (but not in rats) associated with chronic vitamin B12 inactivation. ( Kennedy, DG; Kennedy, S; McKeever, M; Molloy, A; Scott, JM; Weir, DG; Young, P, 1995) |
| "A synergistic interaction between vitamin B12 deficiency and nitrous oxide exposure was observed." | 1.27 | Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency. ( Combs, MJ; O'Leary, PW; Schilling, RF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (22.42) | 18.7374 |
| 1990's | 26 (15.76) | 18.2507 |
| 2000's | 26 (15.76) | 29.6817 |
| 2010's | 38 (23.03) | 24.3611 |
| 2020's | 38 (23.03) | 2.80 |
| Authors | Studies |
|---|---|
| Farhat, W | 1 |
| Pariente, A | 1 |
| Mijahed, R | 1 |
| Redmond, J | 1 |
| Cruse, B | 1 |
| Kiers, L | 1 |
| Sluyts, Y | 1 |
| Vanherpe, P | 1 |
| Amir, R | 1 |
| Vanhoenacker, F | 1 |
| Vermeersch, P | 1 |
| Caré, W | 1 |
| Dufayet, L | 1 |
| Piot, MA | 1 |
| Crassard, I | 1 |
| Manceau, P | 1 |
| Niclot, P | 1 |
| Batisse, A | 1 |
| Vodovar, D | 1 |
| Wong, J | 1 |
| Viyasar, T | 1 |
| Layton, B | 1 |
| Lauder, J | 1 |
| Temple, C | 2 |
| Horowitz, BZ | 2 |
| Grzych, G | 2 |
| Gernez, E | 2 |
| Deheul, S | 2 |
| Kim, I | 2 |
| Ljungblad, UW | 2 |
| Astrup, H | 1 |
| Mørkrid, L | 1 |
| Hager, HB | 1 |
| Lindberg, M | 2 |
| Eklund, EA | 2 |
| Bjørke-Monsen, AL | 2 |
| Rootwelt, T | 1 |
| Tangeraas, T | 2 |
| Marsden, P | 1 |
| Sharma, AA | 1 |
| Rotella, JA | 1 |
| Sood, R | 1 |
| Parent, T | 1 |
| Southwell, TG | 1 |
| Diprose, WK | 1 |
| Bigio, IKL | 1 |
| Elliot, T | 1 |
| Anderson, NE | 1 |
| Saeves, I | 1 |
| Yoon, JY | 1 |
| Klein, JP | 1 |
| Davion, JB | 1 |
| Dobbelaere, D | 1 |
| Carton, L | 1 |
| Guichard, JC | 1 |
| Girot, M | 1 |
| Humbert, L | 1 |
| Bennis, A | 1 |
| Joncquel, M | 1 |
| Chieux, V | 1 |
| Joly, A | 1 |
| Nasserdine, P | 1 |
| Trillot, N | 1 |
| Douillard, C | 1 |
| Pigny, P | 1 |
| Tard, C | 1 |
| Paris, A | 1 |
| Lake, L | 1 |
| Joseph, A | 1 |
| Workman, A | 1 |
| Walton, J | 1 |
| Hayton, T | 1 |
| Evangelou, N | 1 |
| Lilleker, JB | 1 |
| Ayling, RM | 1 |
| Nicholl, D | 1 |
| Noyce, AJ | 1 |
| Gancarczyk, N | 1 |
| Lakghomi, A | 1 |
| Kaut, O | 1 |
| Er, C | 1 |
| Breen, K | 1 |
| Cohen, AT | 1 |
| Vitte, T | 1 |
| Castrioto, A | 1 |
| Schmitt, E | 1 |
| Moro, E | 1 |
| Potel, SR | 1 |
| Gardin, TM | 1 |
| Yang, A | 1 |
| Moeller, JJ | 1 |
| Quraishi, IH | 1 |
| Kanin, M | 1 |
| Nguyen, J | 1 |
| Rotblatt, M | 1 |
| Blair, C | 2 |
| Tremonti, C | 1 |
| Edwards, L | 1 |
| Haber, PS | 1 |
| Halmagyi, GM | 1 |
| Vive, MGD | 1 |
| Anguelova, GV | 1 |
| Duim, S | 1 |
| Hofstee, HMA | 1 |
| Hughes, G | 1 |
| Moran, E | 1 |
| Dedicoat, MJ | 1 |
| Shen, Q | 1 |
| Lu, H | 1 |
| Wang, H | 1 |
| Xu, Y | 1 |
| Demas, A | 1 |
| Le Boisselier, R | 1 |
| Simonnet, L | 1 |
| De Menibus-Demas, L | 1 |
| Langlois, V | 1 |
| Cochin, JP | 1 |
| Noh, T | 1 |
| Osman, G | 1 |
| Chedid, M | 1 |
| Hefzy, H | 1 |
| Seed, A | 1 |
| Jogia, M | 1 |
| Thayabaran, D | 1 |
| Burrage, D | 1 |
| Lewis, B | 1 |
| Nelson, G | 1 |
| Vu, T | 1 |
| Judge, B | 1 |
| van den Hoven, C | 1 |
| Lambrechts, S | 1 |
| Reynders, T | 1 |
| Padayachee, Y | 1 |
| Richards, C | 1 |
| Morgan, O | 1 |
| Vallès, M | 1 |
| Soler, D | 1 |
| Albu, S | 1 |
| Kumru, H | 1 |
| Lee, M | 1 |
| Abbas, A | 1 |
| Lee, O | 1 |
| Record, CJ | 1 |
| Moodley, KK | 1 |
| Nirmalananthan, N | 1 |
| Oomens, T | 1 |
| Fokkema, TMM | 1 |
| van den Bogaard, B | 1 |
| de Metz, J | 1 |
| van Nieuwenhuizen, RC | 1 |
| Riezebos, RK | 1 |
| Kuipers, RS | 1 |
| Einsiedler, M | 1 |
| Voulleminot, P | 1 |
| Demuth, S | 1 |
| Kalaaji, P | 1 |
| Bogdan, T | 1 |
| Gauer, L | 1 |
| Reschwein, C | 1 |
| Nadaj-Pakleza, A | 1 |
| de Sèze, J | 1 |
| Kremer, L | 1 |
| Schroder, I | 1 |
| Bigaut, K | 1 |
| Mahgoub, AE | 1 |
| Deliwala, SS | 1 |
| Bachuwa, G | 1 |
| Paulus, MC | 1 |
| Wijnhoven, AM | 1 |
| Maessen, GC | 1 |
| Blankensteijn, SR | 1 |
| van der Heyden, MAG | 1 |
| Pedersen, OB | 1 |
| Hvas, AM | 1 |
| Grove, EL | 1 |
| de Valck, L | 1 |
| Defelippe, VM | 1 |
| Bouwman, NAMG | 1 |
| Swart, G | 1 |
| Lu, Z | 1 |
| Yogendran, S | 1 |
| Offord, J | 1 |
| Sutherland, E | 1 |
| Barnes, S | 1 |
| Palavra, N | 1 |
| Cremer, P | 1 |
| Bolitho, S | 1 |
| Michael Halmagyi, G | 1 |
| Walker, S | 1 |
| Marshall, J | 1 |
| Ginsberg, L | 1 |
| Kaski, D | 1 |
| Kumar, P | 1 |
| Murphy, E | 1 |
| Warner, TT | 1 |
| Glijn, NHP | 1 |
| van der Linde, D | 1 |
| Ertekin, E | 1 |
| van Burg, PLM | 1 |
| Grimbergen, YAM | 1 |
| Libourel, EJ | 1 |
| Middleton, JA | 1 |
| Roffers, JA | 1 |
| Conjaerts, SHP | 1 |
| Bruijnes, JE | 1 |
| Beerhorst, K | 1 |
| Beekman, R | 1 |
| Johnson, K | 1 |
| Mikhail, P | 1 |
| Kim, MG | 1 |
| Bosco, A | 1 |
| Huynh, W | 1 |
| Antonucci, MU | 1 |
| Egan, W | 1 |
| Steinberg, E | 1 |
| Rose, J | 1 |
| Jolobe, OMP | 1 |
| Patel, KK | 1 |
| Mejia Munne, JC | 1 |
| Gunness, VRN | 1 |
| Hersey, D | 1 |
| Alshafai, N | 1 |
| Sciubba, D | 1 |
| Nasser, R | 1 |
| Gimbel, D | 1 |
| Cheng, J | 1 |
| Nouri, A | 1 |
| Dong, X | 1 |
| Ba, F | 1 |
| Wang, R | 1 |
| Zheng, D | 1 |
| Lan, SY | 1 |
| Kuo, CY | 1 |
| Chou, CC | 1 |
| Kong, SS | 1 |
| Hung, PC | 1 |
| Tsai, HY | 1 |
| Chen, YC | 1 |
| Lin, JJ | 1 |
| Chou, IJ | 1 |
| Lin, KL | 1 |
| Williamson, J | 1 |
| Huda, S | 1 |
| Damodaran, D | 1 |
| Kim, S | 1 |
| Lee, SH | 1 |
| Bang, M | 1 |
| Norris, F | 1 |
| Mallia, P | 1 |
| Friedlander, G | 1 |
| Davies, T | 1 |
| Blaauw, J | 1 |
| Schut, ES | 1 |
| Steinberg, J | 1 |
| Delehaye, F | 1 |
| Villarbu, M | 1 |
| Salaun, V | 1 |
| Bracquemart, C | 1 |
| Goyer, I | 1 |
| Bodet, D | 1 |
| Gullestrup, A | 1 |
| Jensen, RB | 1 |
| Bøgevig, S | 1 |
| Nilsson, PM | 1 |
| Francis, A | 1 |
| Crossley, R | 1 |
| Brady, S | 1 |
| Cheng, HM | 1 |
| Park, JH | 1 |
| Hernstadt, D | 1 |
| Chaugny, C | 1 |
| Simon, J | 1 |
| Collin-Masson, H | 1 |
| De Beauchêne, M | 1 |
| Cabral, D | 1 |
| Fagniez, O | 1 |
| Veyssier-Belot, C | 1 |
| Morris, N | 1 |
| Lynch, K | 1 |
| Greenberg, SA | 1 |
| Singh, SK | 1 |
| Misra, UK | 1 |
| Kalita, J | 1 |
| Bora, HK | 1 |
| Murthy, RC | 1 |
| Thompson, AG | 1 |
| Leite, MI | 1 |
| Lunn, MP | 1 |
| Bennett, DL | 1 |
| Pugliese, RS | 1 |
| Slagle, EJ | 1 |
| Oettinger, GR | 1 |
| Neuburger, KJ | 1 |
| Ambrose, TM | 1 |
| Duque, MA | 1 |
| Kresak, JL | 1 |
| Falchook, A | 1 |
| Harris, NS | 1 |
| Staubli, G | 1 |
| Baumgartner, M | 1 |
| Sass, JO | 1 |
| Hersberger, M | 1 |
| Garakani, A | 1 |
| Jaffe, RJ | 1 |
| Savla, D | 1 |
| Welch, AK | 1 |
| Protin, CA | 1 |
| Bryson, EO | 1 |
| McDowell, DM | 1 |
| Massey, TH | 1 |
| Pickersgill, TT | 1 |
| J Peall, K | 1 |
| Forster, VJ | 1 |
| van Delft, FW | 1 |
| Baird, SF | 1 |
| Mair, S | 1 |
| Skinner, R | 1 |
| Halsey, C | 1 |
| Sleeman, I | 1 |
| Wiblin, L | 1 |
| Burn, D | 1 |
| Renard, D | 1 |
| Dutray, A | 1 |
| Remy, A | 1 |
| Castelnovo, G | 1 |
| Labauge, P | 1 |
| Alt, RS | 1 |
| Morrissey, RP | 1 |
| Gang, MA | 1 |
| Hoffman, RS | 1 |
| Schaumburg, HH | 1 |
| Walter, JH | 1 |
| Probasco, JC | 1 |
| Felling, RJ | 1 |
| Carson, JT | 1 |
| Dorsey, ER | 1 |
| Niessen, TM | 1 |
| Weimann, J | 1 |
| Waclawik, AJ | 1 |
| Luzzio, CC | 1 |
| Juhasz-Pocsine, K | 1 |
| Hamilton, V | 1 |
| Miller, MA | 1 |
| Martinez, V | 1 |
| McCarthy, R | 1 |
| Patel, MM | 1 |
| Doran, M | 1 |
| Rassam, SS | 1 |
| Jones, LM | 1 |
| Underhill, S | 1 |
| Diamond, AL | 1 |
| Diamond, R | 1 |
| Freedman, SM | 1 |
| Thomas, FP | 1 |
| Kulkarni, PR | 1 |
| Dal, D | 1 |
| Celiker, V | 1 |
| Ahn, SC | 1 |
| Brown, AW | 1 |
| Loeb, I | 1 |
| De Coster, J | 1 |
| Shulman, RM | 1 |
| Geraghty, TJ | 1 |
| Tadros, M | 1 |
| Singer, MA | 1 |
| Lazaridis, C | 1 |
| Nations, SP | 1 |
| Wolfe, GI | 1 |
| Cartner, M | 1 |
| Sinnott, M | 1 |
| Silburn, P | 1 |
| Sethi, NK | 1 |
| Mullin, P | 1 |
| Torgovnick, J | 1 |
| Capasso, G | 1 |
| Winston, GP | 1 |
| Jaiser, SR | 1 |
| Horne, DW | 2 |
| Briggs, WT | 1 |
| Kondo, H | 1 |
| Osborne, ML | 1 |
| Kolhouse, JF | 1 |
| Binder, MJ | 1 |
| Podell, ER | 1 |
| Utley, CS | 1 |
| Abrams, RS | 1 |
| Allen, RH | 1 |
| Steinberg, SE | 1 |
| Campbell, C | 1 |
| Hillman, RS | 1 |
| Dinn, JJ | 1 |
| Weir, DG | 5 |
| McCann, S | 1 |
| Reed, B | 1 |
| Wilson, P | 1 |
| Scott, JM | 7 |
| Linnell, JC | 1 |
| Matthews, DM | 1 |
| van der Westhuyzen, J | 9 |
| Gibson, JE | 2 |
| Gibson, J | 1 |
| Metz, J | 7 |
| Hakim, AM | 1 |
| Cooper, BA | 1 |
| Rosenblatt, DS | 1 |
| Pappius, HM | 1 |
| Perry, J | 6 |
| Chanarin, I | 6 |
| Deacon, R | 6 |
| Lumb, M | 6 |
| Fernandes-Costa, F | 2 |
| McGing, PG | 2 |
| McKenna, B | 1 |
| Hadzic, A | 1 |
| Glab, K | 1 |
| Sanborn, KV | 1 |
| Thys, DM | 1 |
| King, M | 1 |
| Coulter, C | 1 |
| Boyle, RS | 1 |
| Whitby, RM | 1 |
| Kinsella, LJ | 1 |
| Green, R | 1 |
| Uthus, EO | 1 |
| Poellot, RA | 1 |
| McKeever, M | 2 |
| Molloy, A | 2 |
| Young, PB | 2 |
| Kennedy, DG | 3 |
| Kennedy, S | 3 |
| Louis-Ferdinand, RT | 1 |
| McMorrow, AM | 1 |
| Adams, RJ | 1 |
| Rubenstein, MN | 1 |
| Young, P | 1 |
| Flippo, TS | 1 |
| Holder, WD | 1 |
| Brodsky, JB | 1 |
| Carmel, R | 1 |
| Rabinowitz, AP | 1 |
| Mazumder, A | 1 |
| Rösener, M | 1 |
| Dichgans, J | 1 |
| Nestor, PJ | 1 |
| Stark, RJ | 1 |
| Molloy, AM | 1 |
| Takács, J | 1 |
| Brett, A | 1 |
| Beltramello, A | 1 |
| Puppini, G | 1 |
| Cerini, R | 1 |
| El-Dalati, G | 1 |
| Manfredi, M | 1 |
| Roncolato, G | 1 |
| Idone, D | 1 |
| De Togni, L | 1 |
| Turazzini, M | 1 |
| Lee, P | 1 |
| Smith, I | 2 |
| Piesowicz, A | 1 |
| Brenton, D | 1 |
| Mayall, M | 1 |
| Sesso, RM | 1 |
| Iunes, Y | 1 |
| Melo, AC | 1 |
| Lindstedt, G | 1 |
| Göthe, CJ | 1 |
| Petersson, G | 1 |
| Marié, RM | 1 |
| Le Biez, E | 1 |
| Busson, P | 1 |
| Schaeffer, S | 1 |
| Boiteau, L | 1 |
| Dupuy, B | 1 |
| Viader, F | 1 |
| Felmet, K | 1 |
| Robins, B | 1 |
| Tilford, D | 1 |
| Hayflick, SJ | 1 |
| Schneede, J | 1 |
| Refsum, H | 1 |
| Ueland, PM | 1 |
| Qaiyum, M | 1 |
| Sandrasegaran, K | 1 |
| Farrar, D | 1 |
| Monahan, EC | 1 |
| McNeely, JK | 1 |
| Buczulinski, B | 1 |
| Rosner, DR | 1 |
| Deleu, D | 1 |
| Hanssens, Y | 1 |
| Louon, A | 1 |
| Jongen, JC | 1 |
| Koehler, PJ | 1 |
| Franke, CL | 1 |
| Iwata, K | 1 |
| O'Keefe, GB | 1 |
| Karanas, A | 1 |
| van Geffen, GJ | 1 |
| de Boer, HD | 1 |
| Liem, T | 1 |
| Amess, JA | 1 |
| Burman, JF | 1 |
| Rees, GM | 1 |
| Nancekievill, DG | 1 |
| Mollin, DL | 1 |
| Minty, B | 1 |
| Halsey, MJ | 1 |
| Nunn, JF | 1 |
| Adornato, BT | 1 |
| Duffield, MS | 1 |
| Phillips, JI | 1 |
| Vieira-Makings, E | 1 |
| Holloway, KL | 1 |
| Alberico, AM | 1 |
| Muir, M | 1 |
| Viña, JR | 1 |
| Davis, DW | 1 |
| Hawkins, RA | 1 |
| Wright, PG | 1 |
| Heyer, EJ | 1 |
| Simpson, DM | 1 |
| Bodis-Wollner, I | 1 |
| Diamond, SP | 1 |
| Davis, RE | 2 |
| Icke, GC | 1 |
| van Tonder, SV | 2 |
| Ruck, A | 1 |
| Koblin, DD | 1 |
| Biebuyck, JF | 1 |
| Van de List, C | 1 |
| Combs, M | 1 |
| Schilling, RF | 3 |
| Parry, TE | 1 |
| Shane, B | 1 |
| Stokstad, EL | 1 |
| Wilson, SD | 1 |
| McLoughlin, JL | 1 |
| Cantrill, RC | 1 |
| O'Leary, PW | 1 |
| Combs, MJ | 1 |
| Haurani, FI | 1 |
| Kauh, YS | 1 |
| Abboud, EM | 1 |
| Kilroe-Smith, TA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Assessment of Neurological Recovery in Patients Following Nitrous Oxide Abuse[NCT05714917] | 100 participants (Anticipated) | Observational | 2023-04-01 | Not yet recruiting | |||
| Epidemiology of Neurological Complications to Nitrous Oxide Poisoning[NCT05329909] | 135 participants (Anticipated) | Observational | 2022-04-10 | Recruiting | |||
| Folic Acid Clinical Trial (FACT): Biomarker Subgroup Analysis[NCT03981029] | 51 participants (Actual) | Observational | 2011-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 reviews available for nitrous oxide and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Review article: Clinical manifestations and outcomes of chronic nitrous oxide misuse: A systematic review.
Topics: Homocysteine; Humans; Methylmalonic Acid; Nitrous Oxide; Prospective Studies; Vitamin B 12; Vitamin | 2022 |
Peripheral polyneuropathy and acute psychosis from chronic nitrous oxide poisoning: A case report with literature review.
Topics: Adult; Graft vs Host Disease; Humans; Male; Nitrous Oxide; Polyneuropathies; Psychotic Disorders; Vi | 2022 |
Nitrous oxide-induced neurotoxicity: A case report and literature review.
Topics: Adult; Humans; Illicit Drugs; Male; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users? A narrative review.
Topics: Administration, Inhalation; Adolescent; Adult; Anesthetics, Inhalation; Dietary Supplements; Female; | 2021 |
Subacute combined degeneration of the spinal cord following nitrous oxide anesthesia: A systematic review of cases.
Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitrous Oxide; Spinal Cord; Sp | 2018 |
Imaging appearance of myelopathy secondary to nitrous oxide abuse: a case report and review of the literature.
Topics: Adult; Cervical Cord; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Quadriplegia; Spinal | 2019 |
Recreational nitrous oxide abuse related subacute combined degeneration of the spinal cord in adolescents - A case series and literature review.
Topics: Adolescent; Adult; Female; Humans; Male; Nitrous Oxide; Outcome Assessment, Health Care; Subacute Co | 2019 |
Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature.
Topics: Behavior, Addictive; Humans; Neurologic Examination; Nitrous Oxide; Substance-Related Disorders; Vit | 2016 |
Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature.
Topics: Behavior, Addictive; Humans; Neurologic Examination; Nitrous Oxide; Substance-Related Disorders; Vit | 2016 |
Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature.
Topics: Behavior, Addictive; Humans; Neurologic Examination; Nitrous Oxide; Substance-Related Disorders; Vit | 2016 |
Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature.
Topics: Behavior, Addictive; Humans; Neurologic Examination; Nitrous Oxide; Substance-Related Disorders; Vit | 2016 |
Vitamin B12 deficiency and phenylketonuria.
Topics: Humans; Nervous System Diseases; Nitrous Oxide; Phenylketonurias; Vitamin B 12; Vitamin B 12 Deficie | 2011 |
Toxicity of nitrous oxide.
Topics: Animals; Bone Marrow; Folic Acid Deficiency; Humans; Methionine; Nervous System Diseases; Nitrous Ox | 2003 |
Nitrous oxide "whippit" abuse presenting with cobalamin responsive psychosis.
Topics: Adult; Hallucinogens; Humans; Male; Neurotoxicity Syndromes; Nitrous Oxide; Psychoses, Substance-Ind | 2006 |
Nitrous oxide, vitamin B12 deficiency and the methyl folate trap.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Humans; L | 1982 |
Cobalamin metabolism and its clinical aspects.
Topics: Adolescent; Adult; Aged; Aging; Animals; Child; Child, Preschool; Cobamides; Cyanides; Female; Food | 1984 |
Severe neurologic deficit after nitrous oxide anesthesia.
Topics: Anesthesia; Anesthetics, Inhalation; Female; Humans; Middle Aged; Nitrous Oxide; Spinal Cord Disease | 1995 |
Myelotoxic, neurotoxic and reproductive adverse effects of nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Pernicious; Animals; Bone Marrow; | 1994 |
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.
Topics: Anesthesia; Drug Interactions; Gait; Humans; Male; Middle Aged; Nitrous Oxide; Spinal Cord Diseases; | 1993 |
[Nitrous oxide can cause cobalamin deficiency. Vitamin B12 is a simple and cheap remedy].
Topics: Anesthetics, Inhalation; Humans; Nitrous Oxide; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Biological and environmental determinants of plasma homocysteine.
Topics: Adult; Aged; Aging; Alcohol Drinking; Child; Cystathionine beta-Synthase; Diagnosis-Related Groups; | 2000 |
[Subacute combined degeneration of the spinal cord: easy diagnosis, effective treatment].
Topics: Aged; Anemia, Megaloblastic; Anesthetics; Cervical Vertebrae; Female; Humans; Injections, Intramuscu | 2001 |
Cobalamin deficiency and the pathogenesis of nervous system disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Disease Models, Animal; Humans; | 1992 |
Cobalamin and folate: recent developments.
Topics: Anemia, Megaloblastic; Female; Folic Acid; Humans; Methylation; Methylmalonic Acid; Nervous System D | 1992 |
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central N | 1985 |
Clinical chemistry of vitamin B12.
Topics: Absorption; Adult; Alcoholism; Anemia, Pernicious; Ascorbic Acid; Autoantibodies; Biguanides; Biolog | 1985 |
Vitamin B12-folate interrelationships.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Bone Marrow; Folic | 1985 |
1 trial available for nitrous oxide and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Megaloblastic haemopoiesis in patients receiving nitrous oxide.
Topics: Acute Disease; Anemia, Macrocytic; Anemia, Megaloblastic; Anesthesia, Inhalation; Bone Marrow; Cardi | 1978 |
140 other studies available for nitrous oxide and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Extensive Cerebral Venous Thrombosis Secondary to Recreational Nitrous Oxide Abuse.
Topics: Adolescent; Female; Humans; Intracranial Thrombosis; Nitrous Oxide; Venous Thrombosis; Vitamin B 12; | 2022 |
Nitrous oxide-induced neurological disorders: an increasing public health concern.
Topics: Adolescent; Humans; Nervous System Diseases; Nitrous Oxide; Public Health; Substance-Related Disorde | 2022 |
Vitamin B
Topics: Creatinine; Homocysteine; Humans; Methylmalonic Acid; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Defi | 2022 |
[Acute and chronic toxicities associated with the use and misuse of nitrous oxide: An update].
Topics: Administration, Inhalation; Adolescent; Humans; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
The dangers of recreational inhalation of nitrous oxide.
Topics: Adolescent; Humans; Nitrous Oxide; Spinal Cord Diseases; Subacute Combined Degeneration; Vitamin B 1 | 2021 |
Nitrous Oxide "Whippet" Induced Subacute Combined Degeneration of the Spinal Cord.
Topics: Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; Subacute Combi | 2022 |
[Methylmalonic acid: Specific marker of chronic nitrous oxide abuse?]
Topics: Humans; Methylmalonic Acid; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Nitrous oxide abuse induced subacute combined degeneration despite patient initiated B12 supplementation.
Topics: Dietary Supplements; Humans; Illicit Drugs; Nitrous Oxide; Subacute Combined Degeneration; Substance | 2022 |
Breastfed Infants With Spells, Tremor, or Irritability: Rule Out Vitamin B12 Deficiency.
Topics: Breast Feeding; Case-Control Studies; Child; Female; Homocysteine; Humans; Infant; Infant, Newborn; | 2022 |
Acute combined degeneration of the spinal cord following a recreational nitrous oxide binge.
Topics: Humans; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; Vitamin B 12 Deficiency | 2022 |
Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency.
Topics: Case-Control Studies; Homocysteine; Humans; Infant; Infant, Newborn; Methylmalonic Acid; Neonatal Sc | 2022 |
Subacute Combined Degeneration from Nitrous Oxide Use.
Topics: Anesthetics, Inhalation; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord Diseases; Su | 2022 |
Comparison of biomarker for diagnosis of nitrous oxide abuse: challenge of cobalamin metabolic parameters, a retrospective study.
Topics: Biomarkers; Humans; Methylmalonic Acid; Nitrous Oxide; Retrospective Studies; Substance-Related Diso | 2023 |
Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment.
Topics: Adolescent; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Subacute Combined Degeneration; Vitam | 2023 |
Nitrous oxide-induced funicular myelosis and polyneuropathy: a case report with follow-up MR imaging.
Topics: Follow-Up Studies; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Polyneuropathies; Vitamin B 12 | 2023 |
Nitrous oxide misuse: a clue not to be missed in young patients with venous thromboembolism.
Topics: Adult; Female; Humans; Male; Nitrous Oxide; Substance-Related Disorders; Venous Thromboembolism; Ven | 2023 |
Subacute cognitive impairment in B12 vitamin-deficiency neuromyelopathy secondary to nitrous oxide abuse.
Topics: Cognitive Dysfunction; Humans; Nitrous Oxide; Subacute Combined Degeneration; Vitamin B 12; Vitamin | 2023 |
Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis.
Topics: Adolescent; Atrophy; Gastritis; Gastritis, Atrophic; Humans; Male; Nitrous Oxide; Spinal Cord; Subac | 2023 |
Say N
Topics: Anesthetics, Inhalation; Female; Humans; Inhalant Abuse; Nitrous Oxide; Vitamin B 12 Deficiency; You | 2020 |
Vitamin B
Topics: Adult; Anesthetics, Inhalation; Ataxia; Demyelinating Diseases; Female; Humans; Inhalant Abuse; Magn | 2019 |
Metabolic encephalopathy caused by nitrous oxide ('laughing gas') induced hyperammonaemia.
Topics: Adult; Brain Diseases, Metabolic; Confusion; Consciousness Disorders; Diagnosis, Differential; Gastr | 2019 |
Encephalitis secondary to nitrous oxide and vitamin B
Topics: Adult; Confusion; Diagnosis, Differential; Encephalitis; Female; Humans; Illicit Drugs; Nitrous Oxid | 2019 |
Acute cognitive disorder as the initial manifestation of nitrous oxide abusing: a case report.
Topics: Cognition; Female; Humans; Illicit Drugs; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Another extensive nitrous oxide (N2O) myelopathy: The wood for the trees?
Topics: Chronic Disease; Humans; Inhalation Exposure; Magnetic Resonance Imaging; Male; Nitrous Oxide; Pares | 2020 |
Nitrous oxide-induced demyelination: Clinical presentation, diagnosis and treatment recommendations.
Topics: Demyelinating Diseases; Humans; Injections, Intramuscular; Nitrous Oxide; Vitamin B 12; Vitamin B 12 | 2020 |
Lessons of the month: Nitrous oxide-induced functional vitamin B
Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Subacute Combined Degeneration; Vita | 2020 |
No laughing matter - Myeloneuropathy due to heavy chronic nitrous oxide abuse.
Topics: Adult; Analgesics, Non-Narcotic; Emergency Service, Hospital; Female; Humans; Magnetic Resonance Ima | 2021 |
Neuro-image: nitrous oxide-induced myelopathy due to vitamin B
Topics: Humans; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Inhaled nitrous oxide-induced functional B
Topics: Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Oxides; Spinal Cord Diseases; Subacute Comb | 2021 |
[Neurological complications of nitrous oxide consumption. A case report].
Topics: Humans; Male; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency; Young Adult | 2021 |
Nitrous oxide-induced motor-predominant axonal peripheral neuropathy: A phenotype distinct from isolated vitamin B12 deficiency.
Topics: Humans; Nitrous Oxide; Peripheral Nervous System Diseases; Phenotype; Vitamin B 12; Vitamin B 12 Def | 2021 |
[Thromboembolisms due to recreational use of nitrous oxide].
Topics: Female; Humans; Illicit Drugs; Male; Nervous System Diseases; Nitrous Oxide; Peripheral Nervous Syst | 2021 |
A rise in cases of nitrous oxide abuse: neurological complications and biological findings.
Topics: Communicable Disease Control; COVID-19; Humans; Nitrous Oxide; Pandemics; SARS-CoV-2; Vitamin B 12; | 2022 |
Important reminder: nitrous oxide (N
Topics: Adult; Female; Folic Acid; Humans; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2021 |
A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism.
Topics: Adolescent; Adult; Humans; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Pulmonary Emboli | 2021 |
Cerebral venous sinus thrombosis: a complication of nitrous oxide abuse.
Topics: Adult; Humans; Intracranial Thrombosis; Male; Nitrous Oxide; Sinus Thrombosis, Intracranial; Vitamin | 2021 |
Nitrous oxide-induced myeloneuropathy.
Topics: Adult; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Peripheral Nervous System Diseases; Vitami | 2021 |
No laughing matter.
Topics: Anesthetics, Inhalation; Demyelinating Diseases; Humans; Nitrous Oxide; Substance-Related Disorders; | 2017 |
Iatrogenic B12-deficient peripheral neuropathy following nitrous oxide administration for functional tonic leg spasm: A case report.
Topics: Adult; Humans; Iatrogenic Disease; Leg; Male; Nitrous Oxide; Peripheral Nervous System Diseases; Spa | 2017 |
Is nitrous oxide really that joyful?
Topics: Anemia, Hemolytic; Female; Humans; Leukopenia; Nitrous Oxide; Paresis; Substance-Related Disorders; | 2017 |
Peripheral Neuropathy Due to Recreational Use of Nitrous Oxide Presenting After an Ankle Sprain With Foot Drop.
Topics: Ankle Injuries; Electromyography; Gait Disorders, Neurologic; Humans; Illicit Drugs; Male; Nitrous O | 2018 |
[Nitrous oxide-induced polyneuropathy].
Topics: Adolescent; Female; Humans; Male; Nitrous Oxide; Polyneuropathies; Spinal Cord Diseases; Vitamin B 1 | 2017 |
Recreational nitrous oxide-associated neurotoxicity.
Topics: Female; Humans; Neural Conduction; Neurotoxicity Syndromes; Nitrous Oxide; Spinal Cord; Treatment Ou | 2018 |
Subacute Combined Degeneration from Recreational Nitrous Oxide Inhalation.
Topics: Administration, Inhalation; Adult; Anesthetics; Humans; Magnetic Resonance Imaging; Male; Nitrous Ox | 2018 |
Vitamin B
Topics: Emergency Service, Hospital; Female; Humans; Inhalant Abuse; Nervous System Diseases; Nitrous Oxide; | 2018 |
Other aspects of nitrous oxide-related neuromyelopathy.
Topics: Homocysteine; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Spinal Cord; Subacute Combined Dege | 2019 |
Nitrous oxide myelopathy with functional vitamin B
Topics: Adolescent; Humans; Illicit Drugs; Male; Nitrous Oxide; Spinal Cord Diseases; Treatment Outcome; Uni | 2019 |
Double-sidedness of "laughing gas" on the N-methyl-d-aspartate receptor: A case report of acute psychosis associated with nitrous oxide-induced hyperhomocysteinemia.
Topics: Female; Hallucinations; Humans; Hydroxocobalamin; Hyperhomocysteinemia; Nitrous Oxide; Psychotic Dis | 2019 |
Lesson of the month 2: A case of nitrous oxide-induced pancytopenia.
Topics: Adolescent; Female; Humans; Hydroxocobalamin; Nitrous Oxide; Pancytopenia; Vitamin B 12 Deficiency | 2019 |
The Last Laugh - Reversible myeloneuropathy induced by chronic nitrous oxide use.
Topics: Ataxia; Diagnosis, Differential; Humans; Male; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency; | 2018 |
[A patient with leg numbness and micturition symptoms].
Topics: Adult; Gait Disorders, Neurologic; Humans; Hypesthesia; Male; Nitrous Oxide; Urination Disorders; Vi | 2019 |
Psychiatric manifestation and pancytopenia during a sickle cell vaso-occlusive crisis: An unusual etiology.
Topics: Adolescent; Anemia, Sickle Cell; Anesthetics, Inhalation; Arterial Occlusive Diseases; Female; Gait | 2019 |
[Acute neuropathy and liver injury following the abuse of nitrous oxide].
Topics: Denmark; Humans; Liver; Male; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12 Deficiency | 2019 |
Subacute progressive sensorimotor symptoms.
Topics: Adult; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Neurodegenerative Diseas | 2019 |
Subacute combined degeneration of the spinal cord following recreational nitrous oxide use.
Topics: Female; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Physical Therapy Modalities; Spinal Cord; | 2013 |
[Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration].
Topics: Analgesics, Non-Narcotic; Anemia, Sickle Cell; Drug-Related Side Effects and Adverse Reactions; Huma | 2014 |
Severe motor neuropathy or neuronopathy due to nitrous oxide toxicity after correction of vitamin B12 deficiency.
Topics: Homocysteine; Humans; Male; Motor Neuron Disease; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficien | 2015 |
Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Demyelinating Diseases; Disease Models, Animal; Glut | 2015 |
Whippits, nitrous oxide and the dangers of legal highs.
Topics: Adult; Analgesics, Non-Narcotic; Female; Humans; Male; Nervous System Diseases; Nitrous Oxide; Spina | 2015 |
Subacute combined degeneration of the spinal cord in a patient abusing nitrous oxide and self-medicating with cyanocobalamin.
Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Self Medication; Spinal Cord Disea | 2015 |
Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report.
Topics: Adult; Demyelinating Diseases; Female; Humans; Methylmalonic Acid; Nitrous Oxide; Paresthesia; Spina | 2015 |
Laughing Gas in a Pediatric Emergency Department-Fun for All Participants: Vitamin B12 Status Among Medical Staff Working With Nitrous Oxide.
Topics: Adult; Anesthetics, Inhalation; Case-Control Studies; Cross-Sectional Studies; Emergency Service, Ho | 2016 |
Nitrous oxide misuse and vitamin B12 deficiency.
Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Humans; Magnetic Re | 2016 |
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Humans; Leukemi | 2016 |
An unusual cause of falls in a young woman.
Topics: Accidental Falls; Adult; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Chronic Pain; Demyelinat | 2016 |
Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia.
Topics: Afferent Pathways; Anesthetics, Inhalation; Causality; Disease Progression; Gait Ataxia; Humans; Iat | 2009 |
Severe myeloneuropathy from acute high-dose nitrous oxide (N2O) abuse.
Topics: Anesthetics, Inhalation; Demyelinating Diseases; Humans; Male; Nitrous Oxide; Vitamin B 12 Deficienc | 2011 |
Teaching NeuroImages: myelopathy due to B₁₂ deficiency in long-term colchicine treatment and nitrous oxide misuse.
Topics: Adult; Colchicine; Humans; Male; Nitrous Oxide; Spinal Cord Diseases; Substance-Related Disorders; V | 2011 |
Myeloneuropathy from nitrous oxide abuse: unusually high methylmalonic acid and homocysteine levels.
Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Homocysteine; Human | 2003 |
Nitrous oxide "whippit" abuse presenting as clinical B12 deficiency and ataxia.
Topics: Adult; Anesthetics, Inhalation; Ataxia; Humans; Male; Nitrous Oxide; Substance-Related Disorders; Vi | 2004 |
Toxicity after intermittent inhalation of nitrous oxide for analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Anesthetics, Combined; Anesthetics, Inhalation; Drug Interacti | 2004 |
"Whippets"-induced cobalamin deficiency manifesting as cervical myelopathy.
Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; S | 2004 |
Anesthetic management of a strabismus patient with phenylketonuria.
Topics: Anesthesia, General; Anesthetics, Inhalation; Child; Humans; Nitrous Oxide; Paraparesis, Spastic; Ph | 2004 |
Anesthetic management of a strabismus patient with phenylketonuria.
Topics: Anesthesia, General; Anesthetics, Inhalation; Child; Humans; Methyl Ethers; Nitrous Oxide; Oxygen; P | 2004 |
Cobalamin deficiency and subacute combined degeneration after nitrous oxide anesthesia: a case report.
Topics: Adult; Anesthetics, Inhalation; Humans; Male; Nitrous Oxide; Quadriplegia; Urinary Incontinence; Vit | 2005 |
[Conscious sedation by inhalation].
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Conscious Sedation; Contraindications; Humans; Nitrous O | 2005 |
A case of unusual substance abuse causing myeloneuropathy.
Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Nitrous Oxide; Subacute Combined Degeneration; Su | 2007 |
Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review.
Topics: Adult; Anemia, Pernicious; Anesthetics, Inhalation; Female; Humans; Leg; Magnetic Resonance Imaging; | 2008 |
Paralysis caused by "nagging".
Topics: Adult; Female; Humans; Malnutrition; Nitrous Oxide; Paralysis; Spinal Cord Diseases; Substance Abuse | 2007 |
Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Copper; Electron Transport Complex IV; Hu | 2008 |
Effect of dietary and nitrous oxide-induced vitamin B-12 deficiency on uptake of 5-methyltetrahydrofolate by isolated rat hepatocytes.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biological Transport; Cell Membr | 1980 |
Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Dose-Response Relationshi | 1981 |
The effect of nitrous oxide-induced vitamin B12 deficiency on in vivo folate metabolism.
Topics: Animals; Female; Fibrosarcoma; Folic Acid; Liver; Nitrous Oxide; Polyglutamic Acid; Rats; Sarcoma, E | 1981 |
Methyl group deficiency in nerve tissue: a hypothesis to explain the lesion of subacute combined degeneration.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cercopithecus; Disease Models, A | 1980 |
Lipid composition of the brain in the cobalamin inactivated fruit bat Rousettus aegyptiacus.
Topics: Animals; Brain Chemistry; Fatty Acids; Lipids; Neuromuscular Diseases; Nitrous Oxide; Phosphatidylch | 1984 |
Effect of L-dihydroxyphenylalanine (L-dopa) and methionine on tissue S-adenosylmethionine concentrations in cobalamin-inactivated fruit bats.
Topics: Animals; Brain; Chiroptera; Levodopa; Liver; Methionine; Nervous System; Nitrous Oxide; S-Adenosylme | 1984 |
Betaine delays the onset of neurological impairment in nitrous oxide-induced vitamin B-12 deficiency in fruit bats.
Topics: Animals; Ataxia; Betaine; Body Weight; Chiroptera; Diet; Homocysteine; Methionine; Nitrous Oxide; Vi | 1984 |
Local cerebral glucose utilization in two models of B12 deficiency.
Topics: Animals; Brain; Carbon Radioisotopes; Deoxy Sugars; Deoxyglucose; Kinetics; Male; Nitrous Oxide; Org | 1983 |
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.
Topics: Adenosine; Animals; Deoxyadenosines; Folic Acid; Formyltetrahydrofolates; Liver; Male; Methionine; N | 1983 |
Cobalamin inactivation by nitrous oxide produces severe neurological impairment in fruit bats : protection by methionine and aggravation by folates.
Topics: Animals; Chiroptera; Diet; Folic Acid; Formyltetrahydrofolates; Methionine; Nervous System Diseases; | 1982 |
Evidence that the decreased liver folate status following vitamin B-12 inactivation in the mouse is due to increased loss rather than impaired uptake.
Topics: Animals; Folic Acid; Kinetics; Liver; Nitrous Oxide; Rats; Vitamin B 12 Deficiency | 1981 |
The role of methionine and vitamin B12 in folate incorporation by rat liver.
Topics: Animals; Folic Acid; Liver; Methionine; Nitrous Oxide; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
The induction of functional vitamin B-12 deficiency in rats by exposure to nitrous oxide.
Topics: Animals; Bone Marrow; Deoxyuridine; Disease Models, Animal; DNA; Female; Folic Acid; Formyltetrahydr | 1980 |
Neurotoxicity from overuse of nitrous oxide.
Topics: Adolescent; Humans; Male; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency | 1995 |
'Anesthesia paresthetica': nitrous oxide-induced cobalamin deficiency.
Topics: Aged; Anesthetics; Humans; Male; Nitrous Oxide; Paresthesia; Vitamin B 12; Vitamin B 12 Deficiency | 1995 |
Effect of nitrous oxide on nickel deprivation in rats.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Cholesterol; Diet; Growth; Hematocrit; Liver; Male; Nick | 1993 |
An abnormal methylation ratio induces hypomethylation in vitro in the brain of pig and man, but not in rat.
Topics: Animals; Brain; Death; Female; Humans; Methylation; Methyltransferases; Nitrous Oxide; Rats; Rats, W | 1995 |
Combined system disease after nitrous oxide anesthesia: a case report.
Topics: Adult; Anesthesia; Female; Humans; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency | 1995 |
Demonstration of hypomethylation of proteins in the brain of pigs (but not in rats) associated with chronic vitamin B12 inactivation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Female; Methylation; Nitr | 1995 |
Nitrous oxide and fertility.
Topics: Abortion, Spontaneous; Female; Fertility; Humans; Male; Nitrous Oxide; Occupational Exposure; Pregna | 1993 |
Metabolic evidence of cobalamin deficiency in bone marrow cells harvested for transplantation from donors given nitrous oxide.
Topics: Anesthesia; Bone Marrow; Bone Marrow Transplantation; Deoxyuridine; DNA; Humans; Nitrous Oxide; Tiss | 1993 |
Severe combined degeneration of the spinal cord after nitrous oxide anaesthesia in a vegetarian.
Topics: Anesthetics, Inhalation; Diet, Vegetarian; Female; Humans; Middle Aged; Nitrous Oxide; Spinal Cord D | 1996 |
Vitamin B12 myeloneuropathy precipitated by nitrous oxide anaesthesia.
Topics: Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Female; Humans; Nitrous Oxide; Peripheral Ner | 1996 |
Effect of N2O treatment/vitamin B12 deficiency in pigs on tissue concentrations of odd-numbered, branched-chain fatty acids.
Topics: Animals; Brain; Fatty Acids; Kidney; Liver; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Myocardium | 1995 |
[N2O-induced acute funicular myelosis in latent vitamin B 12 deficiency].
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Demyelinating Diseases; Erythrocyte Indices; Female | 1996 |
Myeloneuropathy from whipped cream bulbs presenting as conversion disorder.
Topics: Adult; Central Nervous System Diseases; Conversion Disorder; Diagnosis, Differential; Female; Humans | 1997 |
Subacute combined degeneration of the spinal cord after nitrous oxide anaesthesia: role of magnetic resonance imaging.
Topics: Aged; Anesthetics, Inhalation; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; | 1998 |
Spastic paraparesis after anaesthesia.
Topics: Adolescent; Anesthetics, Inhalation; Humans; Male; Muscle Spasticity; Nitrous Oxide; Paresis; Phenyl | 1999 |
Vitamin B12 deficiency and nitrous oxide.
Topics: Anesthesia, General; Humans; Nervous System Diseases; Nitrous Oxide; Vitamin B 12 Deficiency | 1999 |
Myeloneuropathy following nitrous oxide anesthaesia in a patient with macrocytic anaemia.
Topics: Anemia, Macrocytic; Anesthetics, Inhalation; Demyelinating Diseases; Female; Humans; Magnetic Resona | 1999 |
[Nitrous oxide and cobalamin deficiency].
Topics: Air Pollutants, Occupational; Anesthetics, Inhalation; Gas Scavengers; Humans; Nitrous Oxide; Operat | 1999 |
Nitrous oxide anesthesia-associated myelopathy.
Topics: Adenoma; Aged; Anemia, Pernicious; Anesthetics, Inhalation; Demyelinating Diseases; Humans; Magnetic | 2000 |
Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide.
Topics: Anemia, Megaloblastic; Anesthetics, Inhalation; Athetosis; Developmental Disabilities; Fatigue; Feve | 2000 |
Post-operative paraesthesia.
Topics: Adult; Anesthetics, Inhalation; Demyelinating Autoimmune Diseases, CNS; Diagnosis, Differential; Fem | 2000 |
Nitrous oxide: friend or foe?
Topics: Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, Inhalation; Humans; Nitrous Oxide | 2000 |
Severe neurological impairment in an infant after nitrous oxide anesthesia.
Topics: Anesthetics, Inhalation; Atrophy; Brain; Female; Gastrostomy; Humans; Infant; Jejunostomy; Muscle Hy | 2000 |
Nitrous oxide-induced cobalamin deficiency.
Topics: Folic Acid Deficiency; Humans; Nitrous Oxide; Spinal Cord Diseases; Vitamin B 12 Deficiency | 2001 |
Neurologic problems associated with chronic nitrous oxide abuse in a non-healthcare worker.
Topics: Humans; Inhalation Exposure; Male; Middle Aged; Nervous System Diseases; Nitrous Oxide; Substance-Re | 2001 |
Nitrous oxide and vitamin B12.
Topics: Analgesics, Non-Narcotic; Child; Contraindications; Dose-Response Relationship, Drug; Humans; Nitrou | 2001 |
[Subacute combined degeneration of the spinal cord due to vitamin B12 deficiency: easy diagnosis, effective therapy].
Topics: Anemia, Megaloblastic; Anesthetics; Humans; Malabsorption Syndromes; Mass Screening; Nitrous Oxide; | 2001 |
Selective inactivation of vitamin B12 in rats by nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cytosol; Liver; Methylmalonic Ac | 1978 |
Nitrous oxide and vitamin B12.
Topics: Humans; Hypesthesia; Nitrous Oxide; Peripheral Nervous System Diseases; Vitamin B 12 Deficiency | 1978 |
Demyelinisation in the spinal cord of vitamin B12 deficient fruit bats.
Topics: Animals; Chiroptera; Demyelinating Diseases; Microscopy, Electron; Nitrous Oxide; Spinal Cord Diseas | 1990 |
Postoperative myeloneuropathy: a preventable complication in patients with B12 deficiency.
Topics: Female; Humans; Intervertebral Disc Displacement; Middle Aged; Nitrous Oxide; Peripheral Nervous Sys | 1990 |
The influence of nitrous oxide on methionine, S-adenosylmethionine, and other amino acids.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Brain; Glutathione; | 1986 |
Peripheral nerve conduction in the fruit bat with nitrous oxide induced vitamin b12 deficiency.
Topics: Animals; Chiroptera; Neural Conduction; Nitrous Oxide; Peripheral Nerves; Ulnar Nerve; Vitamin B 12; | 1987 |
Nitrous oxide: clinical and electrophysiologic investigation of neurologic complications.
Topics: Adult; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Humans; Male; Median Nerve; Nerv | 1986 |
Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment.
Topics: Animals; Brain; Chiroptera; Folic Acid; Liver; Methionine; Nervous System Diseases; Nitrous Oxide; S | 1987 |
Dissociation of methionine synthetase (EC 2.1.1.13) activity and impairment of DNA synthesis in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Chiroptera; DNA; Methyltransfera | 1986 |
Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?
Topics: Anesthesia, Inhalation; Humans; Nitrous Oxide; Vitamin B 12 Deficiency | 1986 |
Nitrous oxide and vitamin B12 deficiency interact adversely on rat growth.
Topics: Animals; Growth; Liver; Male; Nitrous Oxide; Rats; Rats, Inbred Strains; Vitamin B 12; Vitamin B 12 | 1986 |
Cobalamin-folate interrelations.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Enzyme Activation; Folic Acid; Humans; Isomerase | 1987 |
Effect of nitrous oxide inactivation of vitamin B12 on the levels of folate coenzymes in rat bone marrow, kidney, brain, and liver.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bone Marrow; Brain; Coenzymes; F | 1986 |
Nitrous oxide induced vitamin B12 deficiency: measurement of methylation reactions in the fruit bat (Rousettus aegyptiacus).
Topics: Animals; Brain; Carbon Radioisotopes; Chiroptera; Ethanolamine; Ethanolamines; In Vitro Techniques; | 1986 |
Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?
Topics: Adult; Erythrocyte Indices; Female; Hematocrit; Humans; Leukocyte Count; Middle Aged; Nervous System | 1986 |
Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Examination; Deoxyuridine; DNA; Drug Interactions; Ma | 1985 |
Methylcobalamin corrects the deleterious in vitro effect of nitrous oxide on thymidylate synthetase.
Topics: Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Methyltransferases; Nitrous Oxide; | 1985 |
Turnover of the methyl moiety of 5-methyltetrahydropteroylglutamic acid in the cobalamin-inactivated rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Male; Nitrous Oxide; Rats; Rats, | 1985 |
Plasma amino acids and tissue methionine levels in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency.
Topics: Amino Acids; Animals; Betaine; Chiroptera; Methionine; Nervous System; Nitrous Oxide; Vitamin B 12 D | 1985 |
Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats.
Topics: Acyltransferases; Adenosine; Anemia, Megaloblastic; Animals; Bone Marrow; Deoxyadenosines; Humans; H | 1985 |