Page last updated: 2024-10-19

nitrous oxide and Coronary Artery Disease

nitrous oxide has been researched along with Coronary Artery Disease in 7 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Research Excerpts

ExcerptRelevanceReference
"Nitrous oxide did not increase the risk of death and cardiovascular complications or surgical-site infection, the emetogenic effect of nitrous oxide can be controlled with antiemetic prophylaxis, and a desired effect of reduced volatile agent use was shown."2.79The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial. ( Beattie, WS; Chan, MT; Devereaux, PJ; Forbes, A; Leslie, K; Myles, PS; Paech, MJ; Peyton, PJ; Schricker, T; Sessler, DI; Silbert, B; Wallace, S, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Bär, S1
Praz, F1
Räber, L1
Fluegge, K2
Tramèr, MR1
Myles, PS2
Leslie, K2
Chan, MT2
Forbes, A1
Peyton, PJ1
Paech, MJ1
Beattie, WS1
Sessler, DI1
Devereaux, PJ1
Silbert, B1
Schricker, T1
Wallace, S1
Razavi, C1
Saha, S1
Bo, L1
Li, J1
Peyton, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040]Phase 2172 participants (Anticipated)Interventional2021-06-30Recruiting
Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).[NCT00430989]Phase 47,112 participants (Actual)Interventional2007-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cardiac Arrest

(NCT00430989)
Timeframe: 30 days

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)15
N2O Free Group (FiO2 0.3)19

Hospital Stay (Days)

(NCT00430989)
Timeframe: 30 Days Post Op

InterventionDays (Median)
Nitrous Oxide: 70% N2O (FiO2 0.3)6.1
N2O Free Group (FiO2 0.3)6.1

Myocardial Infarction (MI)

(NCT00430989)
Timeframe: 30 days post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)215
N2O Free Group (FiO2 0.3)219

Pulmonary Embolism

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
N2O Group (FiO2 0.3)18
N2O Free Group (FiO2 0.3)22

Stroke

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)26
N2O Free Group (FiO2 0.3)19

The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.

(NCT00430989)
Timeframe: 30 days post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)283
N2O Free Group (FiO2 0.3)296

Wound Infection

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)321
N2O Free Group (FiO2 0.3)311

Trials

1 trial available for nitrous oxide and Coronary Artery Disease

ArticleYear
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014

Other Studies

6 other studies available for nitrous oxide and Coronary Artery Disease

ArticleYear
Plaque erosion causing ST-elevation myocardial infarction after consumption of cannabis and N
    BMC cardiovascular disorders, 2021, 03-23, Volume: 21, Issue:1

    Topics: Administration, Inhalation; Adult; Anesthetics, Inhalation; Angioplasty, Balloon, Coronary; Coronary

2021
Environmental factors influencing the link between childhood ADHD and risk of adult coronary artery disease.
    Medical hypotheses, 2018, Volume: 110

    Topics: Adult; Air Pollutants; Apelin; Attention Deficit Disorder with Hyperactivity; Child; Coronary Artery

2018
Do we need to know whether nitrous oxide harms patients?
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Anesthesia, General; Anesthetics, Inhalation; Coronary Artery Disease; Female; Humans; Male; Nitrous

2014
Nitrous oxide in general anaesthesia.
    Lancet (London, England), 2015, Jan-31, Volume: 385, Issue:9966

    Topics: Anesthesia, General; Anesthetics, Inhalation; Coronary Artery Disease; Female; Humans; Male; Nitrous

2015
Nitrous oxide in general anaesthesia.
    Lancet (London, England), 2015, Jan-31, Volume: 385, Issue:9966

    Topics: Anesthesia, General; Anesthetics, Inhalation; Coronary Artery Disease; Female; Humans; Male; Nitrous

2015
Nitrous oxide in general anaesthesia - Authors' reply.
    Lancet (London, England), 2015, Jan-31, Volume: 385, Issue:9966

    Topics: Anesthesia, General; Anesthetics, Inhalation; Coronary Artery Disease; Female; Humans; Male; Nitrous

2015