Page last updated: 2024-10-19

nitrous oxide and Cardiovascular Stroke

nitrous oxide has been researched along with Cardiovascular Stroke in 36 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Research Excerpts

ExcerptRelevanceReference
"Nitrous oxide in a concentration of 35% has been shown to ameliorate the pain of acute myocardial infarction."9.04Nitrous oxide as an analgesic in acute myocardial infarction. ( Lown, B; Thompson, PL, 1976)
"The present study was undertaken to examine the electrophysiologic effects of nitrous oxide in the dog heart after inducing myocardial infarction, and to compare these with those of other anesthetics."7.69Electrophysiologic effects of nitrous oxide, a volatile anesthetic, in dogs following myocardial infarction in comparison with other anesthetics. ( Hashimoto, H; Ikeda, K; Imamura, S; Nakashima, M; Oomura, T; Suzuki, Y; Watanabe, S, 1997)
"Nitrous oxide has been associated with increased vascular risk in the perioperative period."6.77Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial. ( Bodenham, A; Gough, MJ; Graham, C; Lewis, SC; Sanders, RD; Warlow, C, 2012)
"In this post hoc subanalysis of the Perioperative Ischemic Evaluation (POISE) trial, we sought to determine whether nitrous oxide was associated with the primary composite outcome of cardiovascular death, nonfatal myocardial infarction (MI), and nonfatal cardiac arrest within 30 days of randomization."5.17Nitrous oxide and serious morbidity and mortality in the POISE trial. ( Arrieta, M; Badner, N; Bryson, GL; Choi, PT; Devereaux, PJ; Foex, P; Forbes, A; Leslie, K; Merchant, RN; Myles, P; Paech, MJ; Paul, J; Peyton, P; Pogue, J; Rao-Melancini, P; Sear, JW; Williamson, E; Xu, S; Yang, H, 2013)
"The administration of nitrous oxide was associated with increased long-term risk of myocardial infarction, but not of death or stroke in patients enrolled in the ENIGMA trial."5.15Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial. ( Chan, MT; Forbes, A; Leslie, K; Myles, PS; Paech, MJ; Peyton, P; Silbert, BS; Williamson, E, 2011)
"The analgesic effect of self-administered nitrous oxide 50%/oxygen 50% ('Entonox" analgesic apparatus) was compared with air given by the same method in a double-blind trial in 81 patients with myocardial infarction."5.04A double-blind trial of patient-controlled nitrous-oxide/oxygen analgesia in myocardial infarction. ( Brown, MG; Ewing, DJ; Hoskins, MR; Irving, JB; Kerr, F; Kirby, BJ, 1975)
"Nitrous oxide in a concentration of 35% has been shown to ameliorate the pain of acute myocardial infarction."5.04Nitrous oxide as an analgesic in acute myocardial infarction. ( Lown, B; Thompson, PL, 1976)
" The results of meta-analyses showed that nitrous oxide-based techniques increased the incidence of pulmonary atelectasis (odds ratio (OR) 1."4.91Nitrous oxide-based techniques versus nitrous oxide-free techniques for general anaesthesia. ( Jia, RH; Jia, WQ; Kuriyama, A; Liu, Y; Luo, XF; Ma, B; Sun, R; Tian, JH; Yang, K; Zhang, P, 2015)
"The present study was undertaken to examine the electrophysiologic effects of nitrous oxide in the dog heart after inducing myocardial infarction, and to compare these with those of other anesthetics."3.69Electrophysiologic effects of nitrous oxide, a volatile anesthetic, in dogs following myocardial infarction in comparison with other anesthetics. ( Hashimoto, H; Ikeda, K; Imamura, S; Nakashima, M; Oomura, T; Suzuki, Y; Watanabe, S, 1997)
"The cardiovascular effects of halothane-nitrous oxide anesthesia, and beta-receptor blockade with either propranolol or practolol, were studied in 15 dogs in which severe myocardial infarction had been induced ten days earlier."3.65Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction. ( Bennett, MJ; Clarke, TN; Foëx, P; Prys-Roberts, C; Roberts, JG; Ryder, WA, 1976)
"Nitrous oxide has been associated with increased vascular risk in the perioperative period."2.77Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial. ( Bodenham, A; Gough, MJ; Graham, C; Lewis, SC; Sanders, RD; Warlow, C, 2012)
"Because the patient developed acute renal failure and furosemide did not show diuretic effect, hemodialysis was used."1.30[Perioperative management for acute abdominal aortic obstruction in a patient with acute myocardial reinfarction associated with acute renal failure]. ( Ishiyama, T; Tsujitou, T, 1997)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199026 (72.22)18.7374
1990's2 (5.56)18.2507
2000's1 (2.78)29.6817
2010's7 (19.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nagele, P1
Brown, F1
Gage, BF1
Gibson, DW1
Miller, JP1
Jaffe, AS1
Apple, FS1
Scott, MG1
Imberger, G1
Orr, A1
Thorlund, K1
Wetterslev, J1
Myles, P2
Møller, AM1
Sun, R1
Jia, WQ1
Zhang, P1
Yang, K1
Tian, JH1
Ma, B1
Liu, Y1
Jia, RH1
Luo, XF1
Kuriyama, A1
Leslie, K2
Myles, PS1
Chan, MT1
Forbes, A2
Paech, MJ2
Peyton, P2
Silbert, BS1
Williamson, E2
Beattie, WS1
Badner, NH1
Sanders, RD1
Graham, C1
Lewis, SC1
Bodenham, A1
Gough, MJ1
Warlow, C1
Devereaux, PJ1
Rao-Melancini, P1
Xu, S1
Foex, P2
Pogue, J1
Arrieta, M1
Bryson, GL1
Paul, J1
Merchant, RN1
Choi, PT1
Badner, N1
Sear, JW1
Yang, H1
Castle, N1
BELKIN, VS1
LUKOMSKII, PE1
KAZMINA, PV1
PEKKER, IL1
Stern, MS1
Shine, KI1
Hashimoto, H1
Imamura, S1
Watanabe, S1
Oomura, T1
Suzuki, Y1
Ikeda, K1
Nakashima, M1
Ishiyama, T1
Tsujitou, T1
Prys-Roberts, C1
Roberts, JG1
Clarke, TN1
Bennett, MJ1
Ryder, WA1
Kerr, F3
Brown, MG1
Irving, JB3
Hoskins, MR1
Ewing, DJ3
Kirby, BJ3
Daoud, A1
Degeorges, M1
Lassner, J1
Sol, Ch1
Arnulf, G1
Doland, DM1
Eisele, JH1
Reitan, JA1
Miller, RR1
Thompson, PL1
Lown, B1
Hunt, GB1
Ross, DL1
Merin, RG1
Lowenstein, E1
Gelman, S1
Allison, SP1
Prowse, K1
Chamberlain, MJ1
Andersen, LH1
BO, G1
Sundström, G1
Wranne, B1
Hosono, K1
Thornton, JA1
Fleming, JS1
Goldberg, AD1
Baird, D1
Kipsidze, NN1
Capidze, GJ1
Klocke, FJ1
Wittenberg, SM1
Iosava, KV3
Bücklein, G1

Reviews

3 reviews available for nitrous oxide and Cardiovascular Stroke

ArticleYear
Does anaesthesia with nitrous oxide affect mortality or cardiovascular morbidity? A systematic review with meta-analysis and trial sequential analysis.
    British journal of anaesthesia, 2014, Volume: 112, Issue:3

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiovascular Diseases; Heart Arrest; Humans; Myoc

2014
Nitrous oxide-based techniques versus nitrous oxide-free techniques for general anaesthesia.
    The Cochrane database of systematic reviews, 2015, Nov-06, Issue:11

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Humans; Myocardial Infarction; Nausea; Nitrous

2015
Effective relief of acute coronary syndrome.
    Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 2003, Volume: 10, Issue:9

    Topics: Acute Disease; Adrenergic beta-Antagonists; Analgesics; Angina, Unstable; Emergency Nursing; Fibrino

2003

Trials

6 trials available for nitrous oxide and Cardiovascular Stroke

ArticleYear
Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial.
    Anesthesia and analgesia, 2011, Volume: 112, Issue:2

    Topics: Aged; Anesthetics, Inhalation; Biomarkers; Cause of Death; Chi-Square Distribution; Female; Follow-U

2011
Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial.
    British journal of anaesthesia, 2012, Volume: 109, Issue:3

    Topics: Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Endarterectomy, Carotid; Female; Hu

2012
Nitrous oxide and serious morbidity and mortality in the POISE trial.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Confid

2013
A double-blind trial of patient-controlled nitrous-oxide/oxygen analgesia in myocardial infarction.
    Lancet (London, England), 1975, Jun-28, Volume: 1, Issue:7922

    Topics: Adult; Aged; Air; Analgesia; Clinical Trials as Topic; Community Participation; Coronary Care Units;

1975
Nitrous oxide as an analgesic in acute myocardial infarction.
    JAMA, 1976, Mar-01, Volume: 235, Issue:9

    Topics: Acute Disease; Blood Pressure; Clinical Trials as Topic; Drug Tolerance; History, Medieval; Humans;

1976
Cardiovascular effects of 50 per cent nitrous oxide and 50 per cent oxygen mixture.
    Anaesthesia, 1973, Volume: 28, Issue:5

    Topics: Adult; Ambulances; Anesthesia, Inhalation; Blood Pressure; Carbon Dioxide; Cardiac Catheterization;

1973

Other Studies

27 other studies available for nitrous oxide and Cardiovascular Stroke

ArticleYear
High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery.
    American heart journal, 2013, Volume: 166, Issue:2

    Topics: Aged; Electrocardiography; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infa

2013
The enigma of ENIGMA-I.
    Anesthesia and analgesia, 2011, Volume: 112, Issue:2

    Topics: Anesthetics, Inhalation; Biomarkers; Cause of Death; Homocysteine; Humans; Myocardial Infarction; Ni

2011
[On the use of nitrous oxide in stenocardia and myocardial infaraction in first aid conditions].
    Terapevticheskii arkhiv, 1961, Volume: 33

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Angina Pectoris; First Aid; Humans; Myocardial Infa

1961
[TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCT IN A STATE OF SHOCK].
    Sovetskaia meditsina, 1963, Volume: 27

    Topics: Geriatrics; Heparin; Humans; Hydrocortisone; Hypertension; Myocardial Infarction; Nitrous Oxide; Nor

1963
[NITROUS OXIDE ANESTHESIA WITH PIPOLPHEN PREMEDICATION IN MYOCARDIAL INFARCT AT A FIRST AID STATION].
    Sovetskaia meditsina, 1965, Volume: 28

    Topics: Anesthesia; Anesthesia, Inhalation; First Aid; Humans; Myocardial Infarction; Nitrous Oxide; Premedi

1965
Nitrous oxide and oxygen in coronary artery disease.
    JAMA, 1981, Jan-09, Volume: 245, Issue:2

    Topics: Hemodynamics; Humans; Myocardial Infarction; Nitrous Oxide; Oxygen; Pain

1981
Electrophysiologic effects of nitrous oxide, a volatile anesthetic, in dogs following myocardial infarction in comparison with other anesthetics.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Dogs; Electrocardiography; Heart; Myocardial Infarction; Nitrous O

1997
[Perioperative management for acute abdominal aortic obstruction in a patient with acute myocardial reinfarction associated with acute renal failure].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:9

    Topics: Acute Disease; Acute Kidney Injury; Aged; Anesthesia, General; Anesthetics, Combined; Aorta, Abdomin

1997
Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction.
    Anesthesiology, 1976, Volume: 45, Issue:3

    Topics: Acetylcholine; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Coronary Circulation; Dogs

1976
[Nitrous oxide analgesia in myocardial infarction (author's transl)].
    La Nouvelle presse medicale, 1977, Nov-19, Volume: 6, Issue:39

    Topics: Adult; Aged; Carbon Dioxide; Humans; Meperidine; Middle Aged; Myocardial Infarction; Nitrous Oxide;

1977
[Nitrous oxide analgesia in myocardial infarct].
    La Nouvelle presse medicale, 1978, Feb-18, Volume: 7, Issue:7

    Topics: Analgesia; Myocardial Infarction; Nitrous Oxide

1978
Letter: Nitrous oxide in myocardial infarction.
    JAMA, 1976, Sep-13, Volume: 236, Issue:11

    Topics: Hemodynamics; Humans; Myocardial Infarction; Nitrous Oxide; Pain

1976
Nitrous oxide in myocardial infarction.
    JAMA, 1976, Nov-01, Volume: 236, Issue:18

    Topics: Acute Disease; Analgesics; Animals; Dogs; Heart; Hemodynamics; Humans; Morphine; Myocardial Infarcti

1976
Comparison of effects of three anesthetic agents on induction of ventricular tachycardia in a canine model of myocardial infarction.
    Circulation, 1988, Volume: 78, Issue:1

    Topics: Animals; Dogs; Droperidol; Drug Combinations; Electric Stimulation; Electrophysiology; Fentanyl; Hal

1988
Is anesthesia beneficial for the ischemic heart? III.
    Anesthesiology, 1986, Volume: 64, Issue:2

    Topics: Adult; Age Factors; Aged; Anesthesia; Coronary Circulation; Coronary Disease; Hemodynamics; Humans;

1986
Nitrous-oxide analgesia in myocardial infarction.
    Lancet (London, England), 1972, Jan-08, Volume: 1, Issue:7741

    Topics: Adult; Aged; Analgesia; Blood Pressure; Cardiac Output; Electrocardiography; Female; Heart Rate; Hum

1972
Failure of insulin response to glucose load during operation and after myocardial infarction.
    Lancet (London, England), 1967, Mar-04, Volume: 1, Issue:7488

    Topics: Blood Glucose; Extracorporeal Circulation; Fatty Acids; Glucose Tolerance Test; Halothane; Humans; H

1967
Closing volume. Influence of extrabronchial factors.
    Scandinavian journal of clinical and laboratory investigation, 1974, Volume: 34, Issue:1

    Topics: Adult; Age Factors; Airway Obstruction; Blood Volume; Bronchi; Humans; Liver Cirrhosis; Methods; Mid

1974
ASOS anesthesia morbidity and mortality survey.
    Journal of oral surgery (American Dental Association : 1965), 1974, Volume: 32, Issue:10

    Topics: Administration, Oral; Anesthesia, Dental; Anesthesia, General; Anesthesia, Local; Anesthesiology; Ce

1974
Natural history of the ischemic heart disease, especially of the myocardial infarction.
    Japanese circulation journal, 1972, Volume: 36, Issue:1

    Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis; Cardiac Catheterization; Coronary Vessels; Dye Dilut

1972
[Therapy of coronary insufficiency with carbochromen].
    Arzneimittel-Forschung, 1970, Volume: 20

    Topics: Acute Disease; Adult; Aged; Angina Pectoris; Blood Circulation; Blood Pressure; Chronic Disease; Cor

1970
Nitrous oxide analgesia in acute myocardial infarction.
    British heart journal, 1972, Volume: 34, Issue:2

    Topics: Acute Disease; Analgesia; Humans; Myocardial Infarction; Nitrous Oxide

1972
Heterogeneity of coronary blood flow in human coronary artery disease and experimental myocardial infarction.
    The American journal of cardiology, 1969, Volume: 24, Issue:6

    Topics: Animals; Coronary Disease; Coronary Vessel Anomalies; Coronary Vessels; Dogs; Krypton; Myocardial In

1969
[On the evaluation of the effect of narcotic remedies on the thrombogenic characteristics of the blood in patients with acute myocardial infarction].
    Kardiologiia, 1967, Volume: 7, Issue:7

    Topics: Adult; Aged; Angina Pectoris; Blood Coagulation; Blood Coagulation Tests; Female; Fibrinolysis; Huma

1967
[Status of the blood acid-base equilibrium in patients with acute myocardial infarct under analgesic anesthesia with nitrous oxide].
    Terapevticheskii arkhiv, 1968, Volume: 40, Issue:3

    Topics: Acid-Base Equilibrium; Adult; Aged; Analgesia; Female; Humans; Male; Middle Aged; Myocardial Infarct

1968
[Nitrous oxide analgesia and myocardial lesions].
    Der Anaesthesist, 1968, Volume: 17, Issue:11

    Topics: Anesthesia, Inhalation; Expert Testimony; Female; Germany, West; Humans; Jurisprudence; Myocardial I

1968
[Thrombogenetic properties of the blood of patients with acute myocardial infarct in analgesia with nitrous oxide and oxygen].
    Sovetskaia meditsina, 1966, Volume: 29, Issue:8

    Topics: Analgesia; Blood Coagulation; Humans; Myocardial Infarction; Nitrous Oxide; Thrombelastography

1966