Page last updated: 2024-10-19

nitrous oxide and Cardiovascular Diseases

nitrous oxide has been researched along with Cardiovascular Diseases in 35 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"Nitrous oxide did not increase the risk of death and cardiovascular complications or surgical-site infection, the emetogenic effect of nitrous oxide can be controlled with antiemetic prophylaxis, and a desired effect of reduced volatile agent use was shown."2.79The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial. ( Beattie, WS; Chan, MT; Devereaux, PJ; Forbes, A; Leslie, K; Myles, PS; Paech, MJ; Peyton, PJ; Schricker, T; Sessler, DI; Silbert, B; Wallace, S, 2014)
"There are also possible effects on postoperative wound infections and neuropsychological function, although the multifactorial nature of these complications should be considered."2.50Nitrous oxide and perioperative outcomes. ( Kaye, AD; Ko, H; Urman, RD, 2014)
"Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action."2.39[Hypertension in the patients with impaired glucose tolerance]. ( Hano, T; Nishio, I, 1996)
"Nitrous oxide has become over the last few years a public health problem in many countries."1.91Nitrous oxide: a unique official French addictovigilance national survey. ( Aquizerate, A; Daveluy, A; Duval, M; Gérardin, M; Guerlais, M; Istvan, M; Laforgue, EJ; Lionnet, A; Victorri-Vigneau, C, 2023)
"Nitrous oxide was used in less than 10% of the centres, and 15% avoided neuromuscular block when neurophysiological monitoring was used during the surgery."1.38[Questionnaire on the anaesthesiology treatment of patients subjected to posterior fossa neurosurgery]. ( Badenes Quiles, R; Fábregas Juliá, N; Hernández Palazón, J; Honorato, C; Ingelmo Ingelmo, I; Rama-Maceiras, P; Romero Krauchi, O; Rubio Romero, R; Sánchez Ledesma, MJ; Valencia Sola, L, 2012)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199014 (40.00)18.7374
1990's2 (5.71)18.2507
2000's6 (17.14)29.6817
2010's12 (34.29)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Guerlais, M1
Aquizerate, A1
Lionnet, A1
Daveluy, A1
Duval, M1
Gérardin, M1
Istvan, M1
Laforgue, EJ1
Victorri-Vigneau, C1
de Vasconcellos, K1
Sneyd, JR1
Ko, H1
Kaye, AD1
Urman, RD1
Imberger, G1
Orr, A1
Thorlund, K1
Wetterslev, J1
Myles, P1
Møller, AM1
Myles, PS3
Leslie, K3
Chan, MT3
Forbes, A3
Peyton, PJ2
Paech, MJ2
Beattie, WS2
Sessler, DI2
Devereaux, PJ3
Silbert, B1
Schricker, T1
Wallace, S3
Mauderly, JL1
Kracko, D1
Brower, J1
Doyle-Eisele, M1
McDonald, JD1
Lund, AK1
Seilkop, SK1
Davis, E1
Kasza, J1
Fleisher, LA1
Connor, D1
Peyton, P1
Paech, M1
Sessler, D1
Silbert, BS1
Jamrozik, K1
Beattie, S1
Badner, N1
Tomlinson, J1
Nicolas, E1
Lassauzay, C1
Saur, J2
Fluechter, S1
Trinkmann, F2
Papavassiliu, T1
Schoenberg, S1
Weissmann, J1
Haghi, D1
Borggrefe, M2
Kaden, JJ2
gidullin, NSh1
Valeeva, KF1
Gassanov, N1
Zagidullin, ShZ1
Bryson, EO1
Frost, EA1
Berger, M1
Hoffmann, U1
Ingelmo Ingelmo, I1
Fábregas Juliá, N1
Rama-Maceiras, P1
Rubio Romero, R1
Badenes Quiles, R1
Valencia Sola, L1
Romero Krauchi, O1
Honorato, C1
Hernández Palazón, J1
Sánchez Ledesma, MJ1
SANDERS, RJ1
MORROW, AG1
WESTON, TE1
THOMPSON, PW1
Mannsåker, B1
Vikan, T1
Holme, J1
Dworakowski, R1
Walker, S1
Momin, A1
Desai, J1
El-Gamel, A1
Wendler, O1
Kearney, MT1
Shah, AM1
Hano, T1
Nishio, I1
Jacobi McNeil, AG1
Saitoh, K1
Fujita, K1
Watanabe, K1
Suzuki, S1
Osuga, T1
Hiruma, N1
Saotome, H1
Shigematsu, Y1
Shionoya, N1
Yatagawa, T1
Mehta, N1
Iyawe, VI1
Cummin, AR1
Bayley, S1
Saunders, KB1
Bennett, ED1
Prys-Roberts, C2
Corbett, JL1
Kerr, JH1
Smith, AC1
Spalding, JM1
Young, TM1
Liutynskiĭ, IuIu1
Nolte, H1
Meyer, J1
Behnke, AR1
Saltzman, HA1
Martinez, LR1
Norlander, OP1
Bascombe, MJ1
Lewis, CB1
Klavis, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040]Phase 2172 participants (Anticipated)Interventional2021-06-30Recruiting
Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).[NCT00430989]Phase 47,112 participants (Actual)Interventional2007-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cardiac Arrest

(NCT00430989)
Timeframe: 30 days

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)15
N2O Free Group (FiO2 0.3)19

Hospital Stay (Days)

(NCT00430989)
Timeframe: 30 Days Post Op

InterventionDays (Median)
Nitrous Oxide: 70% N2O (FiO2 0.3)6.1
N2O Free Group (FiO2 0.3)6.1

Myocardial Infarction (MI)

(NCT00430989)
Timeframe: 30 days post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)215
N2O Free Group (FiO2 0.3)219

Pulmonary Embolism

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
N2O Group (FiO2 0.3)18
N2O Free Group (FiO2 0.3)22

Stroke

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)26
N2O Free Group (FiO2 0.3)19

The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.

(NCT00430989)
Timeframe: 30 days post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)283
N2O Free Group (FiO2 0.3)296

Wound Infection

(NCT00430989)
Timeframe: 30 Days Post op

Interventionparticipants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)321
N2O Free Group (FiO2 0.3)311

Reviews

7 reviews available for nitrous oxide and Cardiovascular Diseases

ArticleYear
Nitrous oxide: are we still in equipoise? A qualitative review of current controversies.
    British journal of anaesthesia, 2013, Volume: 111, Issue:6

    Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Intraoperative A

2013
Nitrous oxide and perioperative outcomes.
    Journal of anesthesia, 2014, Volume: 28, Issue:3

    Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Lung Diseases; N

2014
Does anaesthesia with nitrous oxide affect mortality or cardiovascular morbidity? A systematic review with meta-analysis and trial sequential analysis.
    British journal of anaesthesia, 2014, Volume: 112, Issue:3

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiovascular Diseases; Heart Arrest; Humans; Myoc

2014
[Value of endothelial dysfunction in cardiovascular diseases and methods of its correction with drugs].
    Kardiologiia, 2010, Volume: 50, Issue:5

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atherosclerosis; Cal

2010
The perioperative implications of tobacco, marijuana, and other inhaled toxins.
    International anesthesiology clinics, 2011,Winter, Volume: 49, Issue:1

    Topics: Administration, Inhalation; Cannabis; Cardiovascular Diseases; Evoked Potentials; Humans; Marijuana

2011
[Hypertension in the patients with impaired glucose tolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:10

    Topics: Arteriosclerosis; Blood Coagulation; Cardiovascular Diseases; Diabetes Complications; Electrolytes;

1996
Hyperbaric oxygenation.
    The New England journal of medicine, 1967, Jun-22, Volume: 276, Issue:25

    Topics: Anesthesia, Inhalation; Animals; Cardiovascular Diseases; Heart Defects, Congenital; Humans; Hyperba

1967

Trials

4 trials available for nitrous oxide and Cardiovascular Diseases

ArticleYear
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
    Lancet (London, England), 2014, Oct-18, Volume: 384, Issue:9952

    Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases;

2014
Nitrous Oxide and Serious Long-term Morbidity and Mortality in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II Trial.
    Anesthesiology, 2015, Volume: 123, Issue:6

    Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Cardiovascular Diseases; Female; Follow-Up Studies

2015
Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: rationale and design.
    American heart journal, 2009, Volume: 157, Issue:3

    Topics: Aged; Anesthetics, Inhalation; Cardiovascular Diseases; Female; Homocysteine; Humans; Length of Stay

2009
Validation of a Doppler technique for beat-to-beat measurement of cardiac output.
    Clinical science (London, England : 1979), 1985, Volume: 69, Issue:4

    Topics: Adult; Aorta; Blood Flow Velocity; Cardiac Output; Cardiovascular Diseases; Electrocardiography; Fem

1985

Other Studies

24 other studies available for nitrous oxide and Cardiovascular Diseases

ArticleYear
Nitrous oxide: a unique official French addictovigilance national survey.
    Frontiers in public health, 2023, Volume: 11

    Topics: Cardiovascular Diseases; Female; France; Humans; Nitrous Oxide; Public Health; Substance-Related Dis

2023
The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases.
    Inhalation toxicology, 2014, Volume: 26, Issue:11

    Topics: Air Pollutants; Ammonia; Animals; Apolipoproteins E; Carbon Monoxide; Cardiovascular Diseases; Dose-

2014
Nitrous oxide use during general anaesthesia for general surgical cases.
    British journal of hospital medicine (London, England : 2005), 2015, Volume: 76, Issue:3

    Topics: Anesthesia, General; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Nitrous Oxide; Postop

2015
Value of Sequels: Is It Safe to Include Nitrous Oxide in Your Anesthetic?
    Anesthesiology, 2015, Volume: 123, Issue:6

    Topics: Anesthetics, Inhalation; Cardiovascular Diseases; Female; Humans; Male; Nitrous Oxide; Postoperative

2015
Nitrous oxide and postoperative cardiovascular morbidity.
    British journal of anaesthesia, 2008, Volume: 101, Issue:5

    Topics: Anesthetics, Inhalation; Cardiovascular Diseases; Confounding Factors, Epidemiologic; Folic Acid; Ho

2008
Interest of 50% nitrous oxide and oxygen premix sedation in gerodontology.
    Clinical interventions in aging, 2009, Volume: 4

    Topics: Aged; Anesthetics, Inhalation; Cardiovascular Diseases; Cognition Disorders; Conscious Sedation; Dem

2009
Noninvasive determination of cardiac output by the inert-gas-rebreathing method--comparison with cardiovascular magnetic resonance imaging.
    Cardiology, 2009, Volume: 114, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Output; Cardiovascular Diseases; Female; Humans;

2009
A comparative evaluation of electrical velocimetry and inert gas rebreathing for the non-invasive assessment of cardiac output.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2011, Volume: 100, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Breath Tests; Cardiac Output; Cardiography,

2011
[Questionnaire on the anaesthesiology treatment of patients subjected to posterior fossa neurosurgery].
    Revista espanola de anestesiologia y reanimacion, 2012, Volume: 59, Issue:3

    Topics: Adult; Airway Obstruction; Anesthesia; Anesthesia Department, Hospital; Anesthesia, Inhalation; Anes

2012
The diagnosis of circulatory shunts by the nitrous oxide test; improvements in technic and methods for quantification of the shunt.
    Circulation, 1958, Volume: 18, Issue:5

    Topics: Cardiovascular Diseases; Diagnostic Techniques, Cardiovascular; Fistula; Humans; Nitrous Oxide; Pros

1958
PRESBYACUSIS. A CLINICAL STUDY.
    The Journal of laryngology and otology, 1964, Volume: 78

    Topics: Aging; Anesthesia; Bendroflumethiazide; Cardiovascular Diseases; Ethinyl Estradiol; Geriatrics; Hear

1964
DENTAL ANAESTHESIA.
    Annals of the Royal College of Surgeons of England, 1964, Volume: 35

    Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Dental; Anesthesia, General; Anesthesia, Inhalation;

1964
[Air pollution and cardiovascular disease in Trondheim].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2004, May-20, Volume: 124, Issue:10

    Topics: Acute Disease; Air Pollutants; Cardiovascular Diseases; Humans; Nitric Oxide; Nitrous Oxide; Norway;

2004
Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure.
    Journal of the American College of Cardiology, 2008, Apr-08, Volume: 51, Issue:14

    Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Endothelium, Va

2008
Pain control--the team approach.
    Dental clinics of North America, 1975, Volume: 19, Issue:4

    Topics: Anesthesia, Dental; Anesthesiology; Blood Pressure; Cardiovascular Diseases; Delirium; Dental Servic

1975
[Dental management of the medically compromised patient. A study of 162 cases].
    Meikai Daigaku shigaku zasshi = The Journal of Meikai University School of Dentistry, 1990, Volume: 19, Issue:3

    Topics: Aged; Anesthesia, Dental; Anesthesia, Local; Cardiovascular Diseases; Dental Care for Disabled; Huma

1990
Treatment of sympathetic overactivity in tetanus.
    Lancet (London, England), 1969, Mar-15, Volume: 1, Issue:7594

    Topics: Adult; Aged; Anesthesia, General; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Diseases; Chi

1969
Anaesthesia for dental extraction: a comparison of various techniques in the author's hands.
    Anaesthesia, 1974, Volume: 29, Issue:5

    Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Cardiovascular Diseases;

1974
[Anesthesia in patients with diabetes].
    Vestnik khirurgii imeni I. I. Grekova, 1972, Volume: 109, Issue:7

    Topics: Anesthesia, General; Blood Glucose; Cardiovascular Diseases; Diabetes Complications; Ethyl Ethers; H

1972
[The possibilities of indications for regional anaesthesia].
    Der Anaesthesist, 1972, Volume: 21, Issue:3

    Topics: Ambulatory Care; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Angiography; B

1972
Arterial oxygen tension during nitrous oxide-oxygen-halothane anaesthesia in patients with cardiovascular and pulmonary disease.
    Acta anaesthesiologica Scandinavica, 1967, Volume: 11, Issue:4

    Topics: Acid-Base Equilibrium; Anesthesia, Inhalation; Carbon Dioxide; Cardiovascular Diseases; Halothane; H

1967
Anaesthesia for hemimandibulectomy in patients with malignant disease.
    British journal of anaesthesia, 1968, Volume: 40, Issue:6

    Topics: Adult; Aged; Anesthesia, General; Carcinoma, Squamous Cell; Cardiovascular Diseases; Female; Halotha

1968
Treatment of cardiovascular disturbances in severe tetanus.
    Proceedings of the Royal Society of Medicine, 1969, Jul-07, Volume: 62, Issue:7

    Topics: Adult; Aged; Cardiovascular Diseases; Child; Chlorpromazine; Female; Halothane; Humans; Male; Nitrou

1969
[The cardiovascular system in occupational lesions].
    Die Medizinische Welt, 1966, Apr-02, Volume: 14

    Topics: Ammonia; Cardiovascular Diseases; Fluoroacetates; Humans; Nitrous Oxide; Occupational Diseases; Phos

1966