nitrous oxide has been researched along with Cardiovascular Diseases in 35 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrous oxide did not increase the risk of death and cardiovascular complications or surgical-site infection, the emetogenic effect of nitrous oxide can be controlled with antiemetic prophylaxis, and a desired effect of reduced volatile agent use was shown." | 2.79 | The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial. ( Beattie, WS; Chan, MT; Devereaux, PJ; Forbes, A; Leslie, K; Myles, PS; Paech, MJ; Peyton, PJ; Schricker, T; Sessler, DI; Silbert, B; Wallace, S, 2014) |
| "There are also possible effects on postoperative wound infections and neuropsychological function, although the multifactorial nature of these complications should be considered." | 2.50 | Nitrous oxide and perioperative outcomes. ( Kaye, AD; Ko, H; Urman, RD, 2014) |
| "Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action." | 2.39 | [Hypertension in the patients with impaired glucose tolerance]. ( Hano, T; Nishio, I, 1996) |
| "Nitrous oxide has become over the last few years a public health problem in many countries." | 1.91 | Nitrous oxide: a unique official French addictovigilance national survey. ( Aquizerate, A; Daveluy, A; Duval, M; Gérardin, M; Guerlais, M; Istvan, M; Laforgue, EJ; Lionnet, A; Victorri-Vigneau, C, 2023) |
| "Nitrous oxide was used in less than 10% of the centres, and 15% avoided neuromuscular block when neurophysiological monitoring was used during the surgery." | 1.38 | [Questionnaire on the anaesthesiology treatment of patients subjected to posterior fossa neurosurgery]. ( Badenes Quiles, R; Fábregas Juliá, N; Hernández Palazón, J; Honorato, C; Ingelmo Ingelmo, I; Rama-Maceiras, P; Romero Krauchi, O; Rubio Romero, R; Sánchez Ledesma, MJ; Valencia Sola, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (40.00) | 18.7374 |
| 1990's | 2 (5.71) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 12 (34.29) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Guerlais, M | 1 |
| Aquizerate, A | 1 |
| Lionnet, A | 1 |
| Daveluy, A | 1 |
| Duval, M | 1 |
| Gérardin, M | 1 |
| Istvan, M | 1 |
| Laforgue, EJ | 1 |
| Victorri-Vigneau, C | 1 |
| de Vasconcellos, K | 1 |
| Sneyd, JR | 1 |
| Ko, H | 1 |
| Kaye, AD | 1 |
| Urman, RD | 1 |
| Imberger, G | 1 |
| Orr, A | 1 |
| Thorlund, K | 1 |
| Wetterslev, J | 1 |
| Myles, P | 1 |
| Møller, AM | 1 |
| Myles, PS | 3 |
| Leslie, K | 3 |
| Chan, MT | 3 |
| Forbes, A | 3 |
| Peyton, PJ | 2 |
| Paech, MJ | 2 |
| Beattie, WS | 2 |
| Sessler, DI | 2 |
| Devereaux, PJ | 3 |
| Silbert, B | 1 |
| Schricker, T | 1 |
| Wallace, S | 3 |
| Mauderly, JL | 1 |
| Kracko, D | 1 |
| Brower, J | 1 |
| Doyle-Eisele, M | 1 |
| McDonald, JD | 1 |
| Lund, AK | 1 |
| Seilkop, SK | 1 |
| Davis, E | 1 |
| Kasza, J | 1 |
| Fleisher, LA | 1 |
| Connor, D | 1 |
| Peyton, P | 1 |
| Paech, M | 1 |
| Sessler, D | 1 |
| Silbert, BS | 1 |
| Jamrozik, K | 1 |
| Beattie, S | 1 |
| Badner, N | 1 |
| Tomlinson, J | 1 |
| Nicolas, E | 1 |
| Lassauzay, C | 1 |
| Saur, J | 2 |
| Fluechter, S | 1 |
| Trinkmann, F | 2 |
| Papavassiliu, T | 1 |
| Schoenberg, S | 1 |
| Weissmann, J | 1 |
| Haghi, D | 1 |
| Borggrefe, M | 2 |
| Kaden, JJ | 2 |
| gidullin, NSh | 1 |
| Valeeva, KF | 1 |
| Gassanov, N | 1 |
| Zagidullin, ShZ | 1 |
| Bryson, EO | 1 |
| Frost, EA | 1 |
| Berger, M | 1 |
| Hoffmann, U | 1 |
| Ingelmo Ingelmo, I | 1 |
| Fábregas Juliá, N | 1 |
| Rama-Maceiras, P | 1 |
| Rubio Romero, R | 1 |
| Badenes Quiles, R | 1 |
| Valencia Sola, L | 1 |
| Romero Krauchi, O | 1 |
| Honorato, C | 1 |
| Hernández Palazón, J | 1 |
| Sánchez Ledesma, MJ | 1 |
| SANDERS, RJ | 1 |
| MORROW, AG | 1 |
| WESTON, TE | 1 |
| THOMPSON, PW | 1 |
| Mannsåker, B | 1 |
| Vikan, T | 1 |
| Holme, J | 1 |
| Dworakowski, R | 1 |
| Walker, S | 1 |
| Momin, A | 1 |
| Desai, J | 1 |
| El-Gamel, A | 1 |
| Wendler, O | 1 |
| Kearney, MT | 1 |
| Shah, AM | 1 |
| Hano, T | 1 |
| Nishio, I | 1 |
| Jacobi McNeil, AG | 1 |
| Saitoh, K | 1 |
| Fujita, K | 1 |
| Watanabe, K | 1 |
| Suzuki, S | 1 |
| Osuga, T | 1 |
| Hiruma, N | 1 |
| Saotome, H | 1 |
| Shigematsu, Y | 1 |
| Shionoya, N | 1 |
| Yatagawa, T | 1 |
| Mehta, N | 1 |
| Iyawe, VI | 1 |
| Cummin, AR | 1 |
| Bayley, S | 1 |
| Saunders, KB | 1 |
| Bennett, ED | 1 |
| Prys-Roberts, C | 2 |
| Corbett, JL | 1 |
| Kerr, JH | 1 |
| Smith, AC | 1 |
| Spalding, JM | 1 |
| Young, TM | 1 |
| Liutynskiĭ, IuIu | 1 |
| Nolte, H | 1 |
| Meyer, J | 1 |
| Behnke, AR | 1 |
| Saltzman, HA | 1 |
| Martinez, LR | 1 |
| Norlander, OP | 1 |
| Bascombe, MJ | 1 |
| Lewis, CB | 1 |
| Klavis, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).[NCT00430989] | Phase 4 | 7,112 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00430989)
Timeframe: 30 days
| Intervention | participants (Number) |
|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) | 15 |
| N2O Free Group (FiO2 0.3) | 19 |
(NCT00430989)
Timeframe: 30 Days Post Op
| Intervention | Days (Median) |
|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) | 6.1 |
| N2O Free Group (FiO2 0.3) | 6.1 |
(NCT00430989)
Timeframe: 30 days post op
| Intervention | participants (Number) |
|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) | 215 |
| N2O Free Group (FiO2 0.3) | 219 |
(NCT00430989)
Timeframe: 30 Days Post op
| Intervention | participants (Number) |
|---|---|
| N2O Group (FiO2 0.3) | 18 |
| N2O Free Group (FiO2 0.3) | 22 |
(NCT00430989)
Timeframe: 30 Days Post op
| Intervention | participants (Number) |
|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) | 26 |
| N2O Free Group (FiO2 0.3) | 19 |
(NCT00430989)
Timeframe: 30 days post op
| Intervention | participants (Number) |
|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) | 283 |
| N2O Free Group (FiO2 0.3) | 296 |
(NCT00430989)
Timeframe: 30 Days Post op
| Intervention | participants (Number) |
|---|---|
| Nitrous Oxide: 70% N2O (FiO2 0.3) | 321 |
| N2O Free Group (FiO2 0.3) | 311 |
7 reviews available for nitrous oxide and Cardiovascular Diseases
| Article | Year |
|---|---|
Nitrous oxide: are we still in equipoise? A qualitative review of current controversies.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Intraoperative A | 2013 |
Nitrous oxide and perioperative outcomes.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Lung Diseases; N | 2014 |
Does anaesthesia with nitrous oxide affect mortality or cardiovascular morbidity? A systematic review with meta-analysis and trial sequential analysis.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiovascular Diseases; Heart Arrest; Humans; Myoc | 2014 |
[Value of endothelial dysfunction in cardiovascular diseases and methods of its correction with drugs].
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atherosclerosis; Cal | 2010 |
The perioperative implications of tobacco, marijuana, and other inhaled toxins.
Topics: Administration, Inhalation; Cannabis; Cardiovascular Diseases; Evoked Potentials; Humans; Marijuana | 2011 |
[Hypertension in the patients with impaired glucose tolerance].
Topics: Arteriosclerosis; Blood Coagulation; Cardiovascular Diseases; Diabetes Complications; Electrolytes; | 1996 |
Hyperbaric oxygenation.
Topics: Anesthesia, Inhalation; Animals; Cardiovascular Diseases; Heart Defects, Congenital; Humans; Hyperba | 1967 |
4 trials available for nitrous oxide and Cardiovascular Diseases
| Article | Year |
|---|---|
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases; | 2014 |
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases; | 2014 |
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases; | 2014 |
The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.
Topics: Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Cardiovascular Diseases; | 2014 |
Nitrous Oxide and Serious Long-term Morbidity and Mortality in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II Trial.
Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Cardiovascular Diseases; Female; Follow-Up Studies | 2015 |
Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: rationale and design.
Topics: Aged; Anesthetics, Inhalation; Cardiovascular Diseases; Female; Homocysteine; Humans; Length of Stay | 2009 |
Validation of a Doppler technique for beat-to-beat measurement of cardiac output.
Topics: Adult; Aorta; Blood Flow Velocity; Cardiac Output; Cardiovascular Diseases; Electrocardiography; Fem | 1985 |
24 other studies available for nitrous oxide and Cardiovascular Diseases
| Article | Year |
|---|---|
Nitrous oxide: a unique official French addictovigilance national survey.
Topics: Cardiovascular Diseases; Female; France; Humans; Nitrous Oxide; Public Health; Substance-Related Dis | 2023 |
The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases.
Topics: Air Pollutants; Ammonia; Animals; Apolipoproteins E; Carbon Monoxide; Cardiovascular Diseases; Dose- | 2014 |
Nitrous oxide use during general anaesthesia for general surgical cases.
Topics: Anesthesia, General; Anesthetics, Inhalation; Cardiovascular Diseases; Humans; Nitrous Oxide; Postop | 2015 |
Value of Sequels: Is It Safe to Include Nitrous Oxide in Your Anesthetic?
Topics: Anesthetics, Inhalation; Cardiovascular Diseases; Female; Humans; Male; Nitrous Oxide; Postoperative | 2015 |
Nitrous oxide and postoperative cardiovascular morbidity.
Topics: Anesthetics, Inhalation; Cardiovascular Diseases; Confounding Factors, Epidemiologic; Folic Acid; Ho | 2008 |
Interest of 50% nitrous oxide and oxygen premix sedation in gerodontology.
Topics: Aged; Anesthetics, Inhalation; Cardiovascular Diseases; Cognition Disorders; Conscious Sedation; Dem | 2009 |
Noninvasive determination of cardiac output by the inert-gas-rebreathing method--comparison with cardiovascular magnetic resonance imaging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Output; Cardiovascular Diseases; Female; Humans; | 2009 |
A comparative evaluation of electrical velocimetry and inert gas rebreathing for the non-invasive assessment of cardiac output.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Breath Tests; Cardiac Output; Cardiography, | 2011 |
[Questionnaire on the anaesthesiology treatment of patients subjected to posterior fossa neurosurgery].
Topics: Adult; Airway Obstruction; Anesthesia; Anesthesia Department, Hospital; Anesthesia, Inhalation; Anes | 2012 |
The diagnosis of circulatory shunts by the nitrous oxide test; improvements in technic and methods for quantification of the shunt.
Topics: Cardiovascular Diseases; Diagnostic Techniques, Cardiovascular; Fistula; Humans; Nitrous Oxide; Pros | 1958 |
PRESBYACUSIS. A CLINICAL STUDY.
Topics: Aging; Anesthesia; Bendroflumethiazide; Cardiovascular Diseases; Ethinyl Estradiol; Geriatrics; Hear | 1964 |
DENTAL ANAESTHESIA.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Dental; Anesthesia, General; Anesthesia, Inhalation; | 1964 |
[Air pollution and cardiovascular disease in Trondheim].
Topics: Acute Disease; Air Pollutants; Cardiovascular Diseases; Humans; Nitric Oxide; Nitrous Oxide; Norway; | 2004 |
Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure.
Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Endothelium, Va | 2008 |
Pain control--the team approach.
Topics: Anesthesia, Dental; Anesthesiology; Blood Pressure; Cardiovascular Diseases; Delirium; Dental Servic | 1975 |
[Dental management of the medically compromised patient. A study of 162 cases].
Topics: Aged; Anesthesia, Dental; Anesthesia, Local; Cardiovascular Diseases; Dental Care for Disabled; Huma | 1990 |
Treatment of sympathetic overactivity in tetanus.
Topics: Adult; Aged; Anesthesia, General; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Diseases; Chi | 1969 |
Anaesthesia for dental extraction: a comparison of various techniques in the author's hands.
Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Cardiovascular Diseases; | 1974 |
[Anesthesia in patients with diabetes].
Topics: Anesthesia, General; Blood Glucose; Cardiovascular Diseases; Diabetes Complications; Ethyl Ethers; H | 1972 |
[The possibilities of indications for regional anaesthesia].
Topics: Ambulatory Care; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Angiography; B | 1972 |
Arterial oxygen tension during nitrous oxide-oxygen-halothane anaesthesia in patients with cardiovascular and pulmonary disease.
Topics: Acid-Base Equilibrium; Anesthesia, Inhalation; Carbon Dioxide; Cardiovascular Diseases; Halothane; H | 1967 |
Anaesthesia for hemimandibulectomy in patients with malignant disease.
Topics: Adult; Aged; Anesthesia, General; Carcinoma, Squamous Cell; Cardiovascular Diseases; Female; Halotha | 1968 |
Treatment of cardiovascular disturbances in severe tetanus.
Topics: Adult; Aged; Cardiovascular Diseases; Child; Chlorpromazine; Female; Halothane; Humans; Male; Nitrou | 1969 |
[The cardiovascular system in occupational lesions].
Topics: Ammonia; Cardiovascular Diseases; Fluoroacetates; Humans; Nitrous Oxide; Occupational Diseases; Phos | 1966 |