Page last updated: 2024-10-19

nitrous oxide and Blood Loss, Surgical

nitrous oxide has been researched along with Blood Loss, Surgical in 13 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Blood Loss, Surgical: Loss of blood during a surgical procedure.

Research Excerpts

ExcerptRelevanceReference
"To compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children."5.08Preoperative ketorolac increases bleeding after tonsillectomy in children. ( MacNeill, HB; Reid, CW; Rhine, EJ; Roberts, DW; Splinter, WM, 1996)
"In a prospective randomised study 52 ASA I patients scheduled for ambulatory pregnancy termination were premedicated with lorazepam and received alfentanil prior to anaesthesia induction with propofol (group P, n = 26) or with sevoflurane 8% (group S, n = 26) using the single breath vital capacity technique."5.08Comparison of sevoflurane and propofol for ambulatory anaesthesia in gynaecological surgery. ( Feiss, P; Lahrimi, A; Nathan, N; Peyclit, A, 1998)
" Ten items (age, body weight, sex, duration of general anesthesia, use of propofol, use of sevoflurane, use of nitrous oxide, use of neostigmine, treatment accompanied with bleeding, and transfusion volume) were selected as risk factors for PONV."3.77Risk factors for nausea and vomiting after day care general anesthesia in mentally challenged patients undergoing dental treatment. ( Ichinohe, T; Kaneko, Y; Miyata, M; Nakata, E; Yumura, J, 2011)
"The main postoperative complications were tonic-clonic seizure and serious infection including septic shock from wound infection and meningitis."1.34Perioperative management for surgical correction of frontoethmoidal encephalomeningocele in children: a review of 102 cases. ( Kaewanuchit, A; Leelanukrom, R; Wacharasint, P, 2007)
"To evaluate the influence of acute isovolemic hemodilution on the dose-response and time course of action of vecuronium, we studied 60 adult patients with and without hemodilution during surgery."1.30The influence of acute normovolemic hemodilution on the dose-response and time course of action of vecuronium. ( An, G; Li, L; Liao, X; Liu, JH; Luo, LK; Tong, SY; Xue, FS; Zhang, RJ, 1998)
"All patients received combined general-epidural anesthesia with isoflurane and nitrous oxide, after insertion of an epidural catheter at T8-T9 dosed with 1."1.30Interleukin-10 production during and after upper abdominal surgery. ( Hashimoto, Y; Honda, I; Kato, M; Matsukawa, S; Murakami, M; Suzuki, H, 1998)
" The pharmacokinetic differences may be related to the differences in the sensitivity to vecuronium between genders."1.30The pharmacokinetics of vecuronium in male and female patients. ( An, G; Liao, X; Luo, LK; Xue, FS; Zou, Q, 1998)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (53.85)18.2507
2000's5 (38.46)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yumura, J1
Nakata, E1
Miyata, M1
Ichinohe, T1
Kaneko, Y1
Yoshitani, K1
Kawaguchi, M1
Iwata, M1
Sasaoka, N1
Inoue, S1
Kurumatani, N1
Furuya, H2
Yamashiro, M1
Leelanukrom, R1
Wacharasint, P1
Kaewanuchit, A1
Luzardo, GE1
Karlnoski, RA1
Williams, B1
Mangar, D1
Camporesi, EM1
Splinter, WM1
Rhine, EJ1
Roberts, DW1
Reid, CW1
MacNeill, HB1
Dilger, JA1
Tetzlaff, JE1
Bell, GR1
Kosmorsky, GS1
Agnor, RC1
O'Hara, JF1
Xue, FS2
Liu, JH1
Liao, X2
Tong, SY1
Li, L1
Zhang, RJ1
An, G2
Luo, LK2
Kato, M1
Honda, I1
Suzuki, H1
Murakami, M1
Matsukawa, S1
Hashimoto, Y1
Zou, Q1
Kuipers, T1
Stocker, HJ1
Gubisch, W1
Greulich, M1
Nathan, N1
Peyclit, A1
Lahrimi, A1
Feiss, P1
Gratacós, E1
Wu, J1
Devlieger, R1
Bonati, F1
Lerut, T1
Vanamo, K1
Deprest, JA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Using Near-infrared Spectroscopy (NIRS) Monitor to Noninvasively Evaluate Hepatic Venous Saturation[NCT01891188]100 participants (Anticipated)Observational2013-06-30Active, not recruiting
Near Infrared Spectroscopy (NIRS) for Heart Failure Assessment in the Outpatient Setting[NCT01577810]100 participants (Anticipated)Interventional2013-06-30Recruiting
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures: Does it Increase Blood Loss and Interventions for Blood Loss and Why Do Anesthesiologists Choose to Use It?[NCT01048658]Phase 4160 participants (Actual)Interventional2009-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Experiencing Side Effects (Nausea, Dizziness)

(NCT01048658)
Timeframe: Post-procedure, within 30 minutes

InterventionParticipants (Count of Participants)
Sevoflurane13
No Sevoflurane11

Number of Participants Needing Intervention to Treat Blood Loss (a Composite of Use of Uterotonics, Re-aspiration, and Bimanual Massage)

Provider report for need to intervene due to blood loss (yes/no) (NCT01048658)
Timeframe: At time of uterine evacuation and immediately post-operatively, an average of 7.1 minutes

InterventionParticipants (Count of Participants)
Sevoflurane20
No Sevoflurane13

Number of Participants With Estimated Blood Loss Greater Than 300 mL (Yes/no)

Procedural blood loss greater than 300 mL. Blood loss was measured in a standardized fashion (amniotic fluid was discarded, blood was separated from tissue, and all gauze surgical drapes weighed). (NCT01048658)
Timeframe: At time of uterine evacuation, an average of 7.1 minutes

InterventionParticipants (Count of Participants)
Sevoflurane12
No Sevoflurane6

Procedure Time: T-test (Time of Speculum Placement to Time Speculum Removed)

Length of procedure from time of speculum placement to time of speculum removal, in minutes. (NCT01048658)
Timeframe: Time of speculum place to time of speculum removal, an average of 7.1 minutes

Interventionminutes (Mean)
Sevoflurane7.0
No Sevoflurane7.3

Patient and Provider Satisfaction With Anesthesia

Scores reported on 10-cm Visual Analog Scale (VAS anchors: 0= not satisfied at all, 10= completely satisfied) . Reported as mean +/- standard deviation. Subjects and providers were blinded to anesthesia method. Subjects and providers completed post-operative questionnaire within 30 minutes of procedure completion. (NCT01048658)
Timeframe: Post-procedure, within 30 minutes

,
Interventioncm (Mean)
Provider SatisfactionPatient Satisfaction
No Sevoflurane9.38.2
Sevoflurane9.48.4

Trials

3 trials available for nitrous oxide and Blood Loss, Surgical

ArticleYear
Comparison of changes in jugular venous bulb oxygen saturation and cerebral oxygen saturation during variations of haemoglobin concentration under propofol and sevoflurane anaesthesia.
    British journal of anaesthesia, 2005, Volume: 94, Issue:3

    Topics: Adult; Aged; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Arthroplasty,

2005
Comparison of changes in jugular venous bulb oxygen saturation and cerebral oxygen saturation during variations of haemoglobin concentration under propofol and sevoflurane anaesthesia.
    British journal of anaesthesia, 2005, Volume: 94, Issue:3

    Topics: Adult; Aged; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Arthroplasty,

2005
Comparison of changes in jugular venous bulb oxygen saturation and cerebral oxygen saturation during variations of haemoglobin concentration under propofol and sevoflurane anaesthesia.
    British journal of anaesthesia, 2005, Volume: 94, Issue:3

    Topics: Adult; Aged; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Arthroplasty,

2005
Comparison of changes in jugular venous bulb oxygen saturation and cerebral oxygen saturation during variations of haemoglobin concentration under propofol and sevoflurane anaesthesia.
    British journal of anaesthesia, 2005, Volume: 94, Issue:3

    Topics: Adult; Aged; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Arthroplasty,

2005
Preoperative ketorolac increases bleeding after tonsillectomy in children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:6

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Anesthet

1996
Comparison of sevoflurane and propofol for ambulatory anaesthesia in gynaecological surgery.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12

    Topics: Abortion, Induced; Activities of Daily Living; Adult; Ambulatory Surgical Procedures; Anesthesia, Ge

1998

Other Studies

10 other studies available for nitrous oxide and Blood Loss, Surgical

ArticleYear
Risk factors for nausea and vomiting after day care general anesthesia in mentally challenged patients undergoing dental treatment.
    The Bulletin of Tokyo Dental College, 2011, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Age Factors; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, Gene

2011
Anesthetic management of a patient with Sturge-Weber syndrome undergoing oral surgery.
    Anesthesia progress, 2006,Spring, Volume: 53, Issue:1

    Topics: Adult; Anesthesia, Dental; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Bl

2006
Perioperative management for surgical correction of frontoethmoidal encephalomeningocele in children: a review of 102 cases.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:9

    Topics: Adolescent; Algorithms; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Bl

2007
Anesthetic management of a parturient with hyperhomocysteinemia.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:6

    Topics: Adult; Anesthesia, Spinal; Anesthetics, Inhalation; Anticoagulants; Blood Coagulation; Blood Coagula

2008
Ischaemic optic neuropathy after spinal fusion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:1

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Loss, Surgi

1998
The influence of acute normovolemic hemodilution on the dose-response and time course of action of vecuronium.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:4

    Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Bl

1998
Interleukin-10 production during and after upper abdominal surgery.
    Journal of clinical anesthesia, 1998, Volume: 10, Issue:3

    Topics: Abdomen; Aged; Alprostadil; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthetics, Inhalation; A

1998
The pharmacokinetics of vecuronium in male and female patients.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Area Under Curve; Blood Loss,

1998
[Effect of anesthesia technique on blood loss in breast reduction-plasty. A study of 56 patients operated on by one surgeon].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1998, Volume: 69, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Blood Coagulation Tests; Blood Loss, Surgical; Dose-Response Relation

1998
Nitrous oxide amniodistention compared with fluid amniodistention reduces operation time while inducing no changes in fetal acid-base status in a sheep model for endoscopic fetal surgery.
    American journal of obstetrics and gynecology, 2002, Volume: 186, Issue:3

    Topics: Acid-Base Equilibrium; Amnion; Animals; Blood Loss, Surgical; Female; Fetoscopy; Insufflation; Isoto

2002