nitrous oxide has been researched along with Bipolar Disorder in 4 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this double-blind randomized controlled trial, 25 adults with BD I/II and current treatment-refractory depression received either: (1) nitrous oxide (20 min at 25% concentration) plus intravenous saline (n = 12), or (2) medical air plus intravenous midazolam (2 mg total; n = 13)." | 5.69 | Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement. ( Belo, S; Choi, M; Choi, S; Detzler, G; Dimick, MK; Goldstein, BI; Herrmann, N; Iazzetta, J; Kim, WSH; Levitt, A; MacIntosh, BJ; McIntyre, RS; Mitchell, RHB; Omrin, D; Orser, BA; Riegert, D; Schaffer, A, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Kerzner, J | 1 |
| Demchenko, I | 1 |
| Wijeysundera, DN | 1 |
| Kennedy, SH | 1 |
| Ladha, KS | 1 |
| Bhat, V | 1 |
| Kim, WSH | 1 |
| Dimick, MK | 1 |
| Omrin, D | 1 |
| Mitchell, RHB | 1 |
| Riegert, D | 1 |
| Levitt, A | 1 |
| Schaffer, A | 1 |
| Belo, S | 1 |
| Iazzetta, J | 1 |
| Detzler, G | 1 |
| Choi, M | 1 |
| Choi, S | 1 |
| Herrmann, N | 1 |
| McIntyre, RS | 1 |
| MacIntosh, BJ | 1 |
| Orser, BA | 1 |
| Goldstein, BI | 1 |
| Martin, RF | 1 |
| Desai, SP | 1 |
| Tym, MK | 1 |
| Alexander, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder[NCT02351869] | Phase 2 | 25 participants (Actual) | Interventional | 2015-08-31 | Terminated (stopped due to This study was terminated due to COVID-19 pandemic-related halting of recruitment in the context of an upcoming replacement of the study MRI scanner.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitrous oxide and Bipolar Disorder
| Article | Year |
|---|---|
Nitrous oxide for the treatment of psychiatric disorders: A systematic review of the clinical trial landscape.
Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Nitrous Oxide; Stress Disorders, Post-Traumati | 2022 |
An Examination of Horace Wells' Life as a Manifestation of Major Depressive and Seasonal Affective Disorders.
Topics: Anesthetics, Inhalation; Bipolar Disorder; Chloroform; Connecticut; Dentistry; Depressive Disorder, | 2016 |
1 trial available for nitrous oxide and Bipolar Disorder
| Article | Year |
|---|---|
Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Treatment-Resistant; Double-Bli | 2023 |
1 other study available for nitrous oxide and Bipolar Disorder
| Article | Year |
|---|---|
Nitrous oxide induced manic relapse.
Topics: Adult; Anesthetics, Inhalation; Bipolar Disorder; Female; Humans; Nitrous Oxide; Pregnancy; Pregnanc | 2011 |