nitrous oxide and Anesthesia studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

Excerpt	Relevance	Reference
"The Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia (ENIGMA)-I and ENIGMA-II were randomized clinical trials that assessed the safety of nitrous oxide anesthesia in patients undergoing noncardiac surgery."	9.51	Safety of Nitrous Oxide Anesthesia in a Selected Group of Patients Undergoing Neurosurgery: An Exploratory Subgroup Analysis of the ENIGMA Trials. ( Cheng, J; Gaudet, J; Gondar, R; Leslie, K; Myles, PS; Nouri, A; Patel, KK; Schaller, K; Sun, X; Tessitore, E, 2022)
"To investigate the overall incidence and associated factors of epileptiform discharges in children during sevoflurane anesthesia."	9.22	Epileptiform EEG discharges during sevoflurane anesthesia in children: A meta-analysis. ( Han, Y; Miao, M; Sun, M; Xu, Y; Yang, Y; Zhang, J; Zhang, L; Zhang, Y, 2022)
" The aim of this prospective, randomized study was to investigate the effects of low-flow sevoflurane anesthesia on the pulmonary functions in patients undergoing laparoscopic cholecystectomy."	9.22	Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery. ( Aksoy, M; But, A; Doger, C; Gokcinar, D; Kahveci, K; Katar, D; Ornek, D, 2016)
"One hundred ASA physical status I and II patients, aged between 18 and 50 years, were randomly assigned to receive either propofol-nitrous oxide or sevoflurane-nitrous oxide maintenance of anesthesia."	9.19	Comparison of cognitive, ambulatory, and psychomotor recovery profiles after day care anesthesia with propofol and sevoflurane. ( Badhe, AS; Parida, S, 2014)
"Although there have been a large number of reports on the effects of opioids on the bispectral index (BIS) during anesthesia, the effects of pentazocine on the BIS have not been reported."	9.15	Pentazocine increases bispectral index without surgical stimulation during nitrous oxide-sevoflurane anesthesia. ( Hagihira, S; Imamura, T; Nagasaka, H; Onuki, K; Onuki, N; Shimada, J; Yamanishi, Y; Yoshikawa, S, 2011)
"The major purpose of this study is to evaluate and compare the clinical characteristics of sevoflurane-nitrous oxide and propofol-nitrous oxide anesthesias conveyed by laryngeal mask airway (LMA) in patients for gynecological procedures."	9.12	Comparison of the anesthesia profiles between sevoflurane-nitrous oxide and propofol-nitrous oxide conveyed by laryngeal mask airway in patients undergoing ambulatory gynecological surgery. ( Chen, CH; Chen, WM; Shyr, MH; Yang, YL, 2006)
"4 mg x kg(-1)) attenuates the occurrence of OCR, but with the reduced occurrence of OCR we were not able to attenuate the occurrence of PONV, therefore the association of OCR and PONV in strabismus surgery in children anesthetized with halothane and nitrous oxide remains unclear, and if there is a link between the two, it could be related to arrhythmias and not bradycardia."	9.12	Association of oculocardiac reflex and postoperative nausea and vomiting in strabismus surgery in children anesthetized with halothane and nitrous oxide. ( Carev, M; Dogas, Z; Karanovic, N; Kardum, G; Ujevic, A, 2006)
" We assessed the effects of desflurane anesthesia on QTc interval and cardiac rhythm and compared them with sevoflurane anesthesia in children."	9.12	The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children. ( Aypar, E; Celiker, A; Karagoz, AH; Ocal, T; Ozer, S, 2007)
" Consequently, propofol consumption was smaller in the entropy group during the whole anesthesia period (P < 0."	9.11	Spectral entropy monitoring is associated with reduced propofol use and faster emergence in propofol-nitrous oxide-alfentanil anesthesia. ( Høymork, S; Mustola, S; Nyblom, S; Sampson, T; Sandin, R; Talja, P; Vakkuri, A; van Gils, M; Viertiö-Oja, H; Yli-Hankala, A, 2005)
"The aim of the current study was to investigate whether there are differences in amplitudes and intrapatient variability of motor evoked potentials to five pulses of transcranial electrical stimulation between ketamine/N2O- and propofol/N2O-based anesthesia."	9.10	Amplitudes and intrapatient variability of myogenic motor evoked potentials to transcranial electrical stimulation during ketamine/N2O- and propofol/N2O-based anesthesia. ( Furuya, H; Inoue, S; Kakimoto, M; Kawaguchi, M; Kitaguchi, K; Morimoto, T; Sakaki, T; Sakamoto, T, 2002)
"A randomized prospective study was performed on the anesthetic induction, maintenance, and recovery characteristics of sevoflurane-nitrous oxide, compared to that of target- controlled propofol and fentanyl anesthesia, for forty day-case hysteroscopic surgery."	9.10	Comparison of sevoflurane-nitrous oxide and target-controlled propofol with fentanyl anesthesia for hysteroscopy. ( Hong, JY; Kim, SM; Oh, JI, 2002)
"The authors investigated whether an intravenous administration of magnesium sulfate reduces propofol infusion requirements during maintenance of propofol-N2O anesthesia."	9.10	Intravenous magnesium sulfate administration reduces propofol infusion requirements during maintenance of propofol-N2O anesthesia: part I: comparing propofol requirements according to hemodynamic responses: part II: comparing bispectral index in control a ( Choi, JC; Kim, C; Kim, JS; Lee, SG; Um, DJ; Yoon, KB, 2002)
"During propofol anesthesia at normoventilation, 50% of brain tumor patients showed signs suggesting cerebral hypoperfusion, but this could not be demonstrated during isoflurane/nitrous oxide anesthesia."	9.09	Jugular bulb oxygen saturation during propofol and isoflurane/nitrous oxide anesthesia in patients undergoing brain tumor surgery. ( Jansen, GF; Kedaria, MB; Odoom, JA; van Praagh, BH, 1999)
" We found that, during propofol anesthesia with or without fentanyl, a heart rate increase > or =10 bpm and a systolic blood pressure increase > or =15 mm Hg are reliable indicators for detecting accidental intravascular injection."	9.09	Fentanyl pretreatment does not impair the reliability of an epinephrine-containing test dose during propofol-nitrous oxide anesthesia. ( Takahashi, S; Tanaka, M; Toyooka, H, 1999)
" Anesthesia was induced and maintained with propofol, nitrous oxide:oxygen (60:40), and fentanyl."	9.09	The potency (ED50) and cardiovascular effects of rapacuronium (Org 9487) during narcotic-nitrous oxide-propofol anesthesia in neonates, infants, and children. ( Bui, DT; Darrow, EJ; Fletcher, JE; Hannallah, RS; Kaplan, RF; Slaven, JS; Tsai, KT, 1999)
"We sought to compare effects of remifentanil- and fentanyl-based anesthesia on the morphology of somatosensory evoked potentials (SSEPs) and speed of recovery from anesthesia."	9.09	Remifentanil- and fentanyl-based anesthesia for intraoperative monitoring of somatosensory evoked potentials. ( Dy, EA; Graziano, GP; Lovely, LK; Samra, SK; Welch, KB, 2001)
" In Groups I and II, anesthesia was induced with propofol (1."	9.08	Sevoflurane for outpatient anesthesia: a comparison with propofol. ( Fredman, B; Klein, K; Nathanson, MH; Smith, I; Wang, J; White, PF, 1995)
"We studied the intensity of neuromuscular block that is adequate for surgical relaxation at different end-tidal levels of enflurane during N2O-O2-fentanyl anesthesia in 30 patients undergoing upper abdominal surgery."	9.08	Dependence of the adequacy of muscle relaxation on the degree of neuromuscular block and depth of enflurane anesthesia during abdominal surgery. ( Olkkola, KT; Tammisto, T, 1995)
"The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children."	9.08	Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children. Comparison of four anesthetic techniques using nitrous oxide with halothane or propofol. ( Kataria, BK; Lea, DE; Milmoe, GJ; Montana, J; Nicodemus, HF; Pudimat, MA; Tefft, MC; Ved, SA; Walden, TL, 1996)
"Sixty-two patients undergoing LH were randomized to receive either isoflurane-N2O or propofol-N2O anesthesia."	9.08	Recovery and outcome after propofol and isoflurane anesthesia in patients undergoing laparoscopic hysterectomy. ( Eriksson, H; Korttila, K; Nelskylä, K; Soikkeli, A, 1997)
"Titrating propofol with BIS monitoring during balanced anesthesia decreased propofol use and significantly improved recovery."	9.08	Bispectral index monitoring allows faster emergence and improved recovery from propofol, alfentanil, and nitrous oxide anesthesia. BIS Utility Study Group. ( Gan, TJ; Glass, PS; Manberg, P; Payne, F; Rosow, C; Sebel, P; Windsor, A, 1997)
" Seventy-eight children, aged 3-12 yr, were allocated randomly to receive either nitrous oxide and halothane or nitrous oxide and a propofol infusion for the maintenance of anesthesia."	9.07	Propofol infusion and the incidence of emesis in pediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Weir, PM; Wilton, NC, 1993)
" This study obtains the infusion requirements of rocuronium in 30 patients in whom anesthesia was maintained with barbiturate-nitrous oxide-opioid, nitrous oxide and enflurane, or nitrous oxide and isoflurane."	9.07	Continuous intravenous infusion of rocuronium (ORG 9426) in patients receiving balanced, enflurane, or isoflurane anesthesia. ( Fragen, RJ; Ling, D; Shanks, CA, 1993)
" The aim of this study was to obtain a precise hemodynamic profile of anesthesia induction with propofol under conditions of daily routine (additional 70% nitrous oxide) and to evaluate the influence of (1) premedication with lormetazepam and (2) additional i."	9.06	[Hemodynamics under propofol-nitrous oxide anesthesia: effects of premedication with lormetazepam and of additional fentanyl]. ( Brüssel, T; Heinecke, A; Meinshausen, E; Prien, T; Van Aken, H, 1987)
"The effects of glycopyrrolate and atropine given prior to thiopental-N2O-halothane anesthesia on bradyarrhythmias associated with the administration of succinylcholine were studied and compared."	9.05	Thiopental-nitrous oxide- halothane anesthesia and repeated succinylcholine: comparison of preoperative glycopyrrolate and atropine administration. ( Eriksen, S; Hommelgaard, P; Sørensen, O; Viby-Mogensen, J, 1980)
" Thirty patients were randomly assigned to receive one of three anesthetics: thiopental, nitrous oxide and oxygen, enflurane, plus muscle relaxant; thiopental, nitrous oxide and oxygen, narcotic, plus muscle relaxant; or spinal anesthesia with tetracaine."	9.05	Liver function in patients with mild alcoholic hepatitis, after enflurane, nitrous oxide-narcotic, and spinal anesthesia. ( Fairley, HB; Glenn, JD; Zinn, SE, 1985)
"We compared dl-sotalol-induced electrocardiographic responses in intact dogs using a repeated-measures design among 1% halothane anesthesia, 1."	8.02	In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state. ( Akie, Y; Goto, A; Hagiwara-Nagasawa, M; Hoshiai, K; Izumi-Nakaseko, H; Kambayashi, R; Kawai, S; Matsumoto, A; Nunoi, Y; Saito, H; Sugiyama, A; Takei, Y, 2021)
"To determine whether continuous administration of nitrous oxide and remifentanil—either alone or together—alters blood flow in oral tissues during sevoflurane anesthesia."	7.81	Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits. ( Ichinohe, T; Kanbe, H; Kasahara, M; Matsuura, N; Okada, R; Okamoto, S, 2015)
" At all three levels of anesthesia, we examined evoked physiological responses to fractional inspiratory ratio variations of oxygen (FiO2) and nitrous oxide (N2O)."	7.77	Effects of isoflurane anesthesia on the cardiovascular function of the C57BL/6 mouse. ( Constantinides, C; Janssen, BJ; Mean, R, 2011)
"In this follow-up investigation of a previous gene association study, we prospectively included 140 healthy individuals undergoing elective surgery under general anesthesia that included 66% nitrous oxide."	7.75	A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia. ( Eberle, C; Födinger, M; Hüpfl, M; Mittlböck, M; Nagele, P; Zeugswetter, B, 2009)
" Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia."	7.75	Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009)
"Data were obtained from 58 patients receiving sufentanil-sevoflurane-nitrous oxide anesthesia."	7.74	The comparability of bispectral index and state entropy index during maintenance of sufentanil-sevoflurane-nitrous oxide anesthesia. ( Aegerter, P; Aimé, I; Fermanian, C; Fischler, M; Laloë, PA; Lefoll-Masson, C; Liu, N; Taylor, G; Verroust, N, 2007)
"The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia."	7.72	Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. ( Boemke, W; Francis, RC; Frerking, I; Höhne, C; Kaczmarczyk, G; Swenson, ER; Vogler, P, 2004)
"This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats."	7.72	Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004)
" Anesthesia was induced with thiopental sodium 4 mg/kg intravenously (IV) and succinylcholine 1 mg/kg IV, and maintained with nitrous oxide (N(2)O) 67% and sevoflurane in oxygen."	7.71	Changes in heart rate variability in sevoflurane and nitrous oxide anesthesia: effects of respiration and depth of anesthesia. ( Nakatsuka, I; Ochiai, R; Takeda, J, 2002)
" Removal of the tumor was performed under propofol, nitrous oxide, and epidural anesthesia."	7.70	[Propofol anesthesia for a patient with insulinoma]. ( Amaki, Y; Fujiwara, C; Kamide, M; Onozawa, H; Sato, Y; Tanifuji, Y, 1998)
"In the present study, we examined the effect of sevoflurane and remifentanil on intraocular pressure (IOP) and fluid dynamics."	7.70	Trabecular outflow facility and formation rate of aqueous humor during anesthesia with sevoflurane-nitrous oxide or sevoflurane-remifentanil in rabbits. ( Artru, AA; Momota, Y, 1999)
"We studied lung function in children with and without asthma receiving anesthesia with sevoflurane."	7.70	Respiratory mechanics during sevoflurane anesthesia in children with and without asthma. ( Habre, W; Scalfaro, P; Sims, C; Sly, PD; Tiller, K, 1999)
"Implicit memory of intraoperatively presented stories was recently detected by using the reading speed paradigm during propofol-alfentanil-nitrous oxide anesthesia."	7.70	No implicit memory for stories played during isoflurane/alfentanil/nitrous oxide anesthesia: a reading speed measurement. ( Hussein, S; Leuwer, M; Lüllwitz, E; Mitzlaff, B; Münte, S; Münte, TF; Piepenbrock, SA, 2000)
"kg-1 in patients receiving nitrous oxide/opioid anesthesia."	7.69	The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. ( Abalos, A; Abou-Donia, MM; Belmont, MR; Eppich, L; Lien, CA; Quessy, S; Savarese, JJ, 1995)
" The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly."	7.69	Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995)
"Ninety-nine ASA physical status 1 or 2 patients undergoing elective surgical procedures under nitrous oxide/opioid/barbiturate anesthesia were studied."	7.69	The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. ( Abalos, A; Abou-Donia, MM; Belmont, MR; Eppich, L; Lien, CA; Quessy, S; Savarese, JJ, 1995)
"DNA single strand breaks were determined in peripheral lymphocytes of neurosurgical patients before and after 180 min of general anesthesia with isoflurane (CAS 26675-46-7)-nitrous oxide-oxygen."	7.68	DNA single strand breaks in peripheral human lymphocytes after anesthesia with isoflurane-nitrous oxide-oxygen. ( Antonini-Rumpf, E; Lanz, E; Reitz, M, 1993)
"Patients undergoing kidney transplantation often suffer from essential hypertension and coronary artery disease, for which perioperative treatment with nifedipine proved to be effective."	7.68	[Anesthesia for renal transplantation: continuous neuromuscular blockade with atracurium and the management of intraoperative hypertension with nifedipine]. ( Blobner, M; Felber, AR; Gögler, S; Jelen, G; Jelen-Esselborn, S, 1993)
"Patients for myocardial revascularization were divided into 50% oxygen-50% nitrogen group (group A) and 50% oxygen-50% nitrous oxide group (group B) according to the kind of gas administered after the induction of anesthesia."	7.68	[Influence of posture changes on hemodynamics under fentanyl-diazepam anesthesia--effects of nitrous oxide]. ( Hosoyamada, A; Kobori, M; Saida, K; Yamamoto, N, 1993)
"15 mg/kg and succinylcholine 1 mg/kg were compared in 26 adult patients (ASA I and II) during nitrous oxide-oxygen-propofol-fentanyl anesthesia."	7.68	Neuromuscular and hemodynamic effects of mivacurium and succinylcholine in adult patients during nitrous oxide-propofol-fentanyl anesthesia. ( Hwang, KH; Kim, SC; Kim, SY; Muteki, T; Ueda, N, 1993)
" Reproducible tce-MERs were recordable from the tibialis anterior muscle during nitrous oxide/opioid anesthesia in 11 patients."	7.68	Low concentrations of isoflurane abolish motor evoked responses to transcranial electrical stimulation during nitrous oxide/opioid anesthesia in humans. ( Drummond, JC; Kalkman, CJ; Ribberink, AA, 1991)
"To determine in infants and children the neuromuscular effect of pipecuronium during alfentanil-N2O/O2 anesthesia, the authors studied 32 ASA Physical Status 1 and 2 pediatric patients undergoing minor elective surgery, divided into three groups according to their age: group 1 included 12 infants, 1."	7.68	Neuromuscular effect of pipecuronium bromide in infants and children during nitrous oxide-alfentanil anesthesia. ( Gemperle, G; Morel, DR; Pittet, JF; Rouge, JC; Tassonyi, E, 1990)
"The effect of morphine, diazepam, N2O/O2 anesthesia on baroreflex control of heart rate in humans was investigated in this study."	7.67	Baroreceptor reflex control of heart rate during morphine sulfate, diazepam, N2O/O2 anesthesia in humans. ( Ebert, TJ; Kampine, JP; Kotrly, KJ; Roerig, DL; Vucins, EJ, 1984)
"Effects of sevoflurane anesthesia on organ blood flow were examined in nine healthy isocapnic pigs using 15-mumol diameter radionuclide-labeled microspheres that were injected into the left atrium."	7.67	Porcine systemic and regional organ blood flow during 1.0 and 1.5 minimum alveolar concentrations of sevoflurane anesthesia without and with 50% nitrous oxide. ( Manohar, M; Parks, CM, 1984)
" In this paper, the authors report the effect of urethane anesthesia on the local cerebral glucose utilization."	7.67	[Alterations in local cerebral glucose utilization during various anesthesia--the effect of urethane and a review]. ( Ishii, S; Ito, M; Miyaoka, M, 1984)
"To test the possibility that mice selectively bred for resistance (HI mice) and susceptibility (LO mice) to nitrous oxide anesthesia have general differences in central nervous system sensitivity to other depressants, we examined the effects of four barbiturates in these two lines of mice."	7.67	Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia. ( Bainton, CR; Eger, EI; Koblin, DD; Lurz, FW; Nelson, NT; O'Connor, B, 1984)
"We determined the dose-response relationships of mivacurium (BW B1090U) in children (2-10 years) during nitrous oxide-halothane anesthesia (0."	7.67	Clinical pharmacology of mivacurium chloride (BW B1090U) in children during nitrous oxide-halothane and nitrous oxide-narcotic anesthesia. ( Brandom, BW; Cook, DR; Dong, ML; Foster, VJ; Horn, MC; McNulty, BF; Sarner, JB; Woelfel, SK, 1989)
"Eighty-one pediatric patients, ranging from neonates to adolescents, were studied during fentanyl-N2O-O2 anesthesia to determine for each of them the vecuronium infusion required to maintain 90-95% neuromuscular block (NMB)."	7.67	Vecuronium infusion requirements in pediatric patients during fentanyl-N2O-O2 anesthesia. ( Meretoja, OA, 1989)
"The purpose of this study was to evaluate neuromuscular and cardiovascular effects of doxacurium chloride, a new long-acting neuromuscular blocking agent, during a stable state of nitrous oxide and narcotic anesthesia."	7.67	The neuromuscular blocking and cardiovascular effects of doxacurium chloride in patients receiving nitrous oxide narcotic anesthesia. ( Abou-Donia, MM; Choi, WW; Forbes, RB; Gergis, SD; Mehta, MP; Murray, DJ; Rudd, GD; Sokoll, MD, 1988)
" When the ventilating gas was changed to nitrous oxide (N2O) 66%, balance oxygen, intraocular pressure increased from 14."	7.66	Nitrous oxide increases intraocular pressure after intravitreal sulfur hexafluoride injection. ( Capuano, C; Hartung, J; Wolf, GL, 1983)
"Arterial acid-base and selected physiologic measures of gopher snakes (Pituophis melanoleucus catenifer) during ketamine or halothane-nitrous oxide anesthesia were compared with base-line values."	7.66	Physiologic and acid-base measures of gopher snakes during ketamine or halothane-nitrous oxide anesthesia. ( Bush, M; Custer, RS, 1980)
"The characteristics of phase II neuromuscular block following repeated intravenous injections of succinylcholine (SCh) were determined in 15 adult patients during enflurane, halothane, or fentanyl-nitrous oxide anesthesia."	7.66	Characteristics of succinylcholine-produced phase II neuromuscular block during enflurane, halothane, and fentanyl anesthesia. ( Hilgenberg, JC; Stoelting, RK, 1981)
"The cardiovascular effects of halothane anesthesia in a mixture of nitrous oxide and oxygen were studied on piglets 7 hr to 25 days of age."	7.65	Age-dependent cardiovascular effects of halothane anesthesia in neonatal pigs. ( Crane, L; Gootman, N; Gootman, PM, 1975)
"Methoxyflurane has been used for general anesthesia at The Montreal Children's Hospital since its clinical introduction in 1960, and has been administered to more than 5000 patients undergoing most types of pediatric operations."	7.64	METHOXYFLURANE ANESTHESIA IN PEDIATRICS: A CLINICAL REPORT. ( DAVENPORT, HT; QUAN, P, 1964)
"Nitrous oxide was randomly administered in concentrations of 0, 20, 40, 60, and 75 vol%, to ten patients for each nitrous oxide concentration."	6.68	Interaction of isoflurane and nitrous oxide combinations similar for median electroencephalographic frequency and clinical anesthesia. ( Röpcke, H; Schwilden, H, 1996)
"Desflurane is a new volatile anaesthetic with an extremely low blood/gas partition coefficient of 0."	6.68	[Awakening from anesthesia and recovery of cognitive function after desflurane or isoflurane]. ( Allhoff, T; Conzen, P; Loscar, M; Ott, E; Peter, K, 1996)
"Nitrous oxide can also inhibit major enzymatic pathways and repeated exposure may lead to neurologic damage."	6.44	Nitrous oxide in pediatric anesthesia: friend or foe? ( Baum, VC; Schmitt, EL, 2008)
"Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia."	6.38	Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. ( Flippo, TS; Holder, WD, 1993)
"The Evaluation of Nitrous Oxide in the Gas Mixture for Anesthesia (ENIGMA)-I and ENIGMA-II were randomized clinical trials that assessed the safety of nitrous oxide anesthesia in patients undergoing noncardiac surgery."	5.51	Safety of Nitrous Oxide Anesthesia in a Selected Group of Patients Undergoing Neurosurgery: An Exploratory Subgroup Analysis of the ENIGMA Trials. ( Cheng, J; Gaudet, J; Gondar, R; Leslie, K; Myles, PS; Nouri, A; Patel, KK; Schaller, K; Sun, X; Tessitore, E, 2022)
"Moreover, the duration of the reactive hyperemia was shorter in the ketamine than in the pentobarbital group (118+/-47 vs."	5.31	Comparison between the effects of pentobarbital or ketamine/nitrous oxide anesthesia on metabolic and endothelial components of coronary reactive hyperemia. ( Pagliaro, P; Penna, C; Rastaldo, R, 2001)
"Thiopental was "trapped" during the early distribution phase to a considerable extent in the vessel-rich tissues of rats simultaneously anesthetized with halothane; this pharmacokinetic interaction might be explained hemodynamically: in many tissues regional blood flow is reduced by halothane; thereby a delayed "washout" of thiopental from the vessel-rich tissues could take place and redistribution would be delayed; additional factors as e."	5.28	Increase of thiopental concentration in tissues of the rat due to an anesthesia with halothane. ( Altmayer, P; Büch, HP; Büch, U; Isenberg, JC, 1991)
" Guaifenesin amplifies the effect of several anaesthetics, which complement one another, allowing the dosage to be decreased and thereby reducing the cardiovascular stress."	5.28	[Combination anesthesia in sheep with ketamine-(fentanyl)-guaifenesin (My 301)-laughing gas-halothane]. ( Blättchen, C; Blümel, G; Brosch, W; Erhardt, W; Roder, J; Schindele, M, 1990)
"To investigate the overall incidence and associated factors of epileptiform discharges in children during sevoflurane anesthesia."	5.22	Epileptiform EEG discharges during sevoflurane anesthesia in children: A meta-analysis. ( Han, Y; Miao, M; Sun, M; Xu, Y; Yang, Y; Zhang, J; Zhang, L; Zhang, Y, 2022)
" The aim of this prospective, randomized study was to investigate the effects of low-flow sevoflurane anesthesia on the pulmonary functions in patients undergoing laparoscopic cholecystectomy."	5.22	Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery. ( Aksoy, M; But, A; Doger, C; Gokcinar, D; Kahveci, K; Katar, D; Ornek, D, 2016)
"One hundred ASA physical status I and II patients, aged between 18 and 50 years, were randomly assigned to receive either propofol-nitrous oxide or sevoflurane-nitrous oxide maintenance of anesthesia."	5.19	Comparison of cognitive, ambulatory, and psychomotor recovery profiles after day care anesthesia with propofol and sevoflurane. ( Badhe, AS; Parida, S, 2014)
"Although there have been a large number of reports on the effects of opioids on the bispectral index (BIS) during anesthesia, the effects of pentazocine on the BIS have not been reported."	5.15	Pentazocine increases bispectral index without surgical stimulation during nitrous oxide-sevoflurane anesthesia. ( Hagihira, S; Imamura, T; Nagasaka, H; Onuki, K; Onuki, N; Shimada, J; Yamanishi, Y; Yoshikawa, S, 2011)
"To determine if specially trained professional clowns allayed preoperative anxiety and resulted in a smooth anesthetic induction compared to the use of midazolam or no intervention."	5.14	Clowns for the prevention of preoperative anxiety in children: a randomized controlled trial. ( Dobija, N; Golan, G; Keidan, I; Perel, A; Tighe, P, 2009)
"Whether nitrous oxide (N(2)O) increases the incidence of postoperative nausea and vomiting (PONV) after laparoscopic gynecologic surgery is still controversial, which may be due to the administration of different concentrations of inspired N(2)O."	5.13	The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study. ( Gan, TJ; Mraovic, B; Simurina, T; Skitarelic, N; Sonicki, Z, 2008)
"4 mg x kg(-1)) attenuates the occurrence of OCR, but with the reduced occurrence of OCR we were not able to attenuate the occurrence of PONV, therefore the association of OCR and PONV in strabismus surgery in children anesthetized with halothane and nitrous oxide remains unclear, and if there is a link between the two, it could be related to arrhythmias and not bradycardia."	5.12	Association of oculocardiac reflex and postoperative nausea and vomiting in strabismus surgery in children anesthetized with halothane and nitrous oxide. ( Carev, M; Dogas, Z; Karanovic, N; Kardum, G; Ujevic, A, 2006)
" Anesthesia was induced with a combination of sevoflurane, nitrous oxide and oxygen."	5.12	Propofol and remifentanil for deep sedation in children undergoing gastrointestinal endoscopy. ( Abu-Shahwan, I; Mack, D, 2007)
" We assessed the effects of desflurane anesthesia on QTc interval and cardiac rhythm and compared them with sevoflurane anesthesia in children."	5.12	The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children. ( Aypar, E; Celiker, A; Karagoz, AH; Ocal, T; Ozer, S, 2007)
"The aim of the current study was to investigate whether there are differences in amplitudes and intrapatient variability of motor evoked potentials to five pulses of transcranial electrical stimulation between ketamine/N2O- and propofol/N2O-based anesthesia."	5.10	Amplitudes and intrapatient variability of myogenic motor evoked potentials to transcranial electrical stimulation during ketamine/N2O- and propofol/N2O-based anesthesia. ( Furuya, H; Inoue, S; Kakimoto, M; Kawaguchi, M; Kitaguchi, K; Morimoto, T; Sakaki, T; Sakamoto, T, 2002)
"Dosage guidelines for muscle relaxants are based on dose-response studies, normally performed after several minutes of stable nitrous oxide (N O)-opioid anesthesia."	5.10	Duration of anesthesia before muscle relaxant injection influences level of paralysis. ( Debaene, B; Donati, F; Plaud, B, 2002)
"The authors investigated whether an intravenous administration of magnesium sulfate reduces propofol infusion requirements during maintenance of propofol-N2O anesthesia."	5.10	Intravenous magnesium sulfate administration reduces propofol infusion requirements during maintenance of propofol-N2O anesthesia: part I: comparing propofol requirements according to hemodynamic responses: part II: comparing bispectral index in control a ( Choi, JC; Kim, C; Kim, JS; Lee, SG; Um, DJ; Yoon, KB, 2002)
"The pressure in air-filled endotracheal cuffs increases steadily throughout general anesthesia with nitrous oxide (N2O)."	5.09	Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. ( Bensaid, S; Duvaldestin, P; Leiutaud, T; Menival, V; Saidi, N; Tu, HN, 1999)
"During propofol anesthesia at normoventilation, 50% of brain tumor patients showed signs suggesting cerebral hypoperfusion, but this could not be demonstrated during isoflurane/nitrous oxide anesthesia."	5.09	Jugular bulb oxygen saturation during propofol and isoflurane/nitrous oxide anesthesia in patients undergoing brain tumor surgery. ( Jansen, GF; Kedaria, MB; Odoom, JA; van Praagh, BH, 1999)
" Anesthesia was induced and maintained with propofol, nitrous oxide:oxygen (60:40), and fentanyl."	5.09	The potency (ED50) and cardiovascular effects of rapacuronium (Org 9487) during narcotic-nitrous oxide-propofol anesthesia in neonates, infants, and children. ( Bui, DT; Darrow, EJ; Fletcher, JE; Hannallah, RS; Kaplan, RF; Slaven, JS; Tsai, KT, 1999)
"We sought to compare effects of remifentanil- and fentanyl-based anesthesia on the morphology of somatosensory evoked potentials (SSEPs) and speed of recovery from anesthesia."	5.09	Remifentanil- and fentanyl-based anesthesia for intraoperative monitoring of somatosensory evoked potentials. ( Dy, EA; Graziano, GP; Lovely, LK; Samra, SK; Welch, KB, 2001)
" In Groups I and II, anesthesia was induced with propofol (1."	5.08	Sevoflurane for outpatient anesthesia: a comparison with propofol. ( Fredman, B; Klein, K; Nathanson, MH; Smith, I; Wang, J; White, PF, 1995)
"We studied the intensity of neuromuscular block that is adequate for surgical relaxation at different end-tidal levels of enflurane during N2O-O2-fentanyl anesthesia in 30 patients undergoing upper abdominal surgery."	5.08	Dependence of the adequacy of muscle relaxation on the degree of neuromuscular block and depth of enflurane anesthesia during abdominal surgery. ( Olkkola, KT; Tammisto, T, 1995)
"The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children."	5.08	Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children. Comparison of four anesthetic techniques using nitrous oxide with halothane or propofol. ( Kataria, BK; Lea, DE; Milmoe, GJ; Montana, J; Nicodemus, HF; Pudimat, MA; Tefft, MC; Ved, SA; Walden, TL, 1996)
"Sixty-two patients undergoing LH were randomized to receive either isoflurane-N2O or propofol-N2O anesthesia."	5.08	Recovery and outcome after propofol and isoflurane anesthesia in patients undergoing laparoscopic hysterectomy. ( Eriksson, H; Korttila, K; Nelskylä, K; Soikkeli, A, 1997)
" Clonidine reduced enflurane requirements, intraoperative tachycardia, and myocardial ischemia (1/28 clonidine patients vs 5/24 placebo, P = 0."	5.07	Premedication with oral and transdermal clonidine provides safe and efficacious postoperative sympatholysis. ( Busse, JR; Drijvers, G; Ellis, JE; Foss, JF; Laff, SP; Mantha, S; McKinsey, JF; Pedlow, S; Shah, M; Sorrentino, MJ, 1994)
" Seventy-eight children, aged 3-12 yr, were allocated randomly to receive either nitrous oxide and halothane or nitrous oxide and a propofol infusion for the maintenance of anesthesia."	5.07	Propofol infusion and the incidence of emesis in pediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Weir, PM; Wilton, NC, 1993)
" This study obtains the infusion requirements of rocuronium in 30 patients in whom anesthesia was maintained with barbiturate-nitrous oxide-opioid, nitrous oxide and enflurane, or nitrous oxide and isoflurane."	5.07	Continuous intravenous infusion of rocuronium (ORG 9426) in patients receiving balanced, enflurane, or isoflurane anesthesia. ( Fragen, RJ; Ling, D; Shanks, CA, 1993)
"Intraocular pressure (IOP) measurements in children are frequently performed under halothane-nitrous oxide anesthesia; however, anesthesia face masks may limit access to the eyes, and tracheal intubation is associated with transient increases in IOP."	5.07	Comparative effects of laryngeal mask airway and endotracheal tube insertion on intraocular pressure in children. ( Stevens, JL; Tychsen, L; Watcha, MF; White, PF, 1992)
"he safety and efficacy of oral transmucosal fentanyl citrate (OTFC) as a preanesthetic medication and the efficacy of droperidol as a prophylactic anti-emetic were evaluated in 100 children aged 2-8 yr undergoing general anesthesia for outpatient surgery."	5.07	Oral transmucosal fentanyl citrate for preanesthetic medication of pediatric day surgery patients with and without droperidol as a prophylactic anti-emetic. ( Friesen, RH; Lockhart, CH, 1992)
" The aim of this study was to obtain a precise hemodynamic profile of anesthesia induction with propofol under conditions of daily routine (additional 70% nitrous oxide) and to evaluate the influence of (1) premedication with lormetazepam and (2) additional i."	5.06	[Hemodynamics under propofol-nitrous oxide anesthesia: effects of premedication with lormetazepam and of additional fentanyl]. ( Brüssel, T; Heinecke, A; Meinshausen, E; Prien, T; Van Aken, H, 1987)
"The effects of glycopyrrolate and atropine given prior to thiopental-N2O-halothane anesthesia on bradyarrhythmias associated with the administration of succinylcholine were studied and compared."	5.05	Thiopental-nitrous oxide- halothane anesthesia and repeated succinylcholine: comparison of preoperative glycopyrrolate and atropine administration. ( Eriksen, S; Hommelgaard, P; Sørensen, O; Viby-Mogensen, J, 1980)
" Thirty patients were randomly assigned to receive one of three anesthetics: thiopental, nitrous oxide and oxygen, enflurane, plus muscle relaxant; thiopental, nitrous oxide and oxygen, narcotic, plus muscle relaxant; or spinal anesthesia with tetracaine."	5.05	Liver function in patients with mild alcoholic hepatitis, after enflurane, nitrous oxide-narcotic, and spinal anesthesia. ( Fairley, HB; Glenn, JD; Zinn, SE, 1985)
" Our approach for anesthesia revealed a combination of fentanyl, low dose propofol and nitrous oxide."	4.95	Anesthetic management of a pediatric patient with Electron Transfer Flavoprotein Dehydrogenase deficiency (ETFDH) and acute appendicitis: case report and review of the literature. ( Astyrakaki, E; Blevrakis, E; Chalkiadakis, G; Chrysos, E; Lilitsis, E; Xenaki, S, 2017)
" Anesthesia was performed with sevoflurane in 40% O2 and without the use of nitrous oxide."	4.91	Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature. ( Accardo, R; Accardo, RR; Arcamone, M; Arcamone, MM; Belli, A; Belli, AA; Caliendo, D; Caliendo, DD; Cascella, M; Cascella, MM; Cuomo, A; Cuomo, AA; De Franciscis, S; De Franciscis, SS; De Luca, E; De Luca, EE; Di Caprio, B; Di Caprio, BB; Di Sauro, F; Di Sauro, FF; Giannoni, G; Giannoni, GG; Iermano, C; Iermano, CC; Maciariello, M; Maciariello, MM; Marracino, M; Marracino, MM; Morelli, E; Morelli, EE; Russo, V; Russo, VV; Viscardi, D; Viscardi, DD, 2015)
" The exposed group was constituted by anesthesia providers who were mainly exposed to the anesthetics sevoflurane and isoflurane (10 ppm) and to a lesser degree to nitrous oxide (150 ppm), and the control group was constituted by physicians who had no exposure to WAGs."	4.02	Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anesthesia providers. ( Arruda, NM; Aun, AG; Braz, JRC; Braz, LG; Braz, MG; Chen, CY; Corrêa, CR; de Carvalho, LR; De Vivo, I; Figueiredo, DBS; Lara, JR; Nogueira, FR; Silva, MAP; Souza, KM, 2021)
"In this prospective observational study, 128 patients aged 18-65 years of American Society of Anesthesiologist physical status I and II undergoing laparoscopic cholecystectomy were enrolled and allocated alternately into two groups, Study Group (Maintenance of anesthesia with sevoflurane 1-2%, oxygen/nitrous oxide mixture; 40/60), Control Group (Maintenance of anesthesia with sevoflurane 1-2%, oxygen/air mixture; 40/60) were analysed and comapared."	3.88	Evaluation of Endotracheal Tube Cuff Pressure in Laparoscopic Cholecystectomy and Postoperative Sore Throat. ( Lakhe, G; Sharma, SM, 2018)
"In 1847, British anesthesia pioneer John Snow (1813-1858) observed that patients did not manifest cyanosis during induction with hypoxic mixtures of ether vapor in air."	3.88	John Snow and the First Second-Gas Effect. ( Alston, TA; Shin, CH, 2018)
"To determine whether continuous administration of nitrous oxide and remifentanil—either alone or together—alters blood flow in oral tissues during sevoflurane anesthesia."	3.81	Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits. ( Ichinohe, T; Kanbe, H; Kasahara, M; Matsuura, N; Okada, R; Okamoto, S, 2015)
" At all three levels of anesthesia, we examined evoked physiological responses to fractional inspiratory ratio variations of oxygen (FiO2) and nitrous oxide (N2O)."	3.77	Effects of isoflurane anesthesia on the cardiovascular function of the C57BL/6 mouse. ( Constantinides, C; Janssen, BJ; Mean, R, 2011)
"This study examines the effects of changing oxygen fractional inspiration ratio (FiO(2)), and nitrous oxide (N(2)O) for the improvement of cardiovascular control of mean arterial blood pressure (MAP) and heart rate (HR) in C57BL/6 mice under isoflurane anesthesia (1."	3.76	Heart rate and blood pressure variability effects as a result of oxygen and nitrous oxide administration in the anesthetized mouse. ( Constantinides, C; Janssen, B; Mean, R, 2010)
"In this follow-up investigation of a previous gene association study, we prospectively included 140 healthy individuals undergoing elective surgery under general anesthesia that included 66% nitrous oxide."	3.75	A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia. ( Eberle, C; Födinger, M; Hüpfl, M; Mittlböck, M; Nagele, P; Zeugswetter, B, 2009)
" Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia."	3.75	Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009)
"The limited potency of nitrous oxide mandates the use of a hyperbaric chamber to produce anesthesia."	3.74	A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. ( Antognini, JF; Atherley, RJ; Carstens, E; Dutton, RC; Eger, EI; Laster, MJ, 2007)
" Anesthesia was shown to interrupt soman-induced seizures and to attenuate edema and cell change in certain sensitive brain areas."	3.74	Cerebral edema induced in mice by a convulsive dose of soman. Evaluation through diffusion-weighted magnetic resonance imaging and histology. ( Bernabé, D; Carpentier, P; Delacour, C; Dorandeu, F; Foquin, A; Lahrech, H; Montigon, O; Segebarth, C; Testylier, G, 2007)
"The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia."	3.72	Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. ( Boemke, W; Francis, RC; Frerking, I; Höhne, C; Kaczmarczyk, G; Swenson, ER; Vogler, P, 2004)
"This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats."	3.72	Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004)
" Anesthesia was induced with thiopental sodium 4 mg/kg intravenously (IV) and succinylcholine 1 mg/kg IV, and maintained with nitrous oxide (N(2)O) 67% and sevoflurane in oxygen."	3.71	Changes in heart rate variability in sevoflurane and nitrous oxide anesthesia: effects of respiration and depth of anesthesia. ( Nakatsuka, I; Ochiai, R; Takeda, J, 2002)
" Removal of the tumor was performed under propofol, nitrous oxide, and epidural anesthesia."	3.70	[Propofol anesthesia for a patient with insulinoma]. ( Amaki, Y; Fujiwara, C; Kamide, M; Onozawa, H; Sato, Y; Tanifuji, Y, 1998)
"In the present study, we examined the effect of sevoflurane and remifentanil on intraocular pressure (IOP) and fluid dynamics."	3.70	Trabecular outflow facility and formation rate of aqueous humor during anesthesia with sevoflurane-nitrous oxide or sevoflurane-remifentanil in rabbits. ( Artru, AA; Momota, Y, 1999)
"We studied lung function in children with and without asthma receiving anesthesia with sevoflurane."	3.70	Respiratory mechanics during sevoflurane anesthesia in children with and without asthma. ( Habre, W; Scalfaro, P; Sims, C; Sly, PD; Tiller, K, 1999)
"Soon after announcement of the first American ether anesthesias in 1846 one started to anesthetize with ether in Europe."	3.70	[Contribution of Berlin clinics and especially the Charité to the development of modern anesthesia in Germany]. ( Kox, WJ; Kühne, H; Wauer, HJ, 2000)
"kg-1 in patients receiving nitrous oxide/opioid anesthesia."	3.69	The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. ( Abalos, A; Abou-Donia, MM; Belmont, MR; Eppich, L; Lien, CA; Quessy, S; Savarese, JJ, 1995)
" The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly."	3.69	Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995)
"Ninety-nine ASA physical status 1 or 2 patients undergoing elective surgical procedures under nitrous oxide/opioid/barbiturate anesthesia were studied."	3.69	The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. ( Abalos, A; Abou-Donia, MM; Belmont, MR; Eppich, L; Lien, CA; Quessy, S; Savarese, JJ, 1995)
"The use of general anesthesia, especially nitrous oxide, for oocyte retrieval has an adverse effect on IVF outcome."	3.69	The impact of different types of anesthesia on in vitro fertilization-embryo transfer treatment outcome. ( Ben-Nun, I; Beyth, Y; Ghetler, Y; Gonen, O; Judeiken, R; Shapiro, A; Shulman, A, 1995)
" Induction and maintenance of anesthesia either with sufentanil and midazolam or with sufentanil and nitrous oxide."	3.69	Comparison of two techniques of narcotic-induced anesthesia for use during recording of magnetic motor evoked potentials in dogs. ( Mattheeuws, DR; Nijs, J; Van Ham, LM; Vanderstraeten, GG, 1996)
", and burnt surface ranging from 6 to 60 per cent, measurements of the mean body temperature are done during anesthesia with halothane, methoxyflurane and ketamine."	3.68	[Mean body temperature during anesthesia in children with burns--its information value and use]. ( Taneva, E, 1993)
"Patients undergoing kidney transplantation often suffer from essential hypertension and coronary artery disease, for which perioperative treatment with nifedipine proved to be effective."	3.68	[Anesthesia for renal transplantation: continuous neuromuscular blockade with atracurium and the management of intraoperative hypertension with nifedipine]. ( Blobner, M; Felber, AR; Gögler, S; Jelen, G; Jelen-Esselborn, S, 1993)
" Forty five women undergoing laparoscopy for gynecological procedure were studied after dividing into four groups; general anesthesia with control ventilation or epidural anesthesia with spontaneous breathing, plus insufflation with carbon dioxide (CO2) or nitrous oxide (N2O)."	3.68	[The effects of anesthetic techniques and insufflating gases on ventilation during laparoscopy]. ( Fukushima, K; Konishi, M; Nishio, I; Noguchi, J; Ochiai, R; Takeda, J, 1993)
"The paper evaluates the level of analgesic protection by assaying cortisol and prolactin levels in two groups of 20 patients each undergoing general anesthesia using two different techniques: TIVA with propofol and fentanyl, and BPN-nitrous oxide."	3.68	[Blood levels of cortisol and prolactin. Are they indices of the degree of protection against surgical stress?]. ( Alpa, E; Bonilauri, M; Faraldi, C; Federici, E; Launo, C; Napoleone, M; Palermo, S; Riverso, P, 1992)
"The effects of age on the pharmacokinetics and pharmacodynamics of vecuronium in eight elderly patients aged 72-86 yr and eight younger adults aged 26-48 yr undergoing elective surgical procedures under nitrous oxide-fentanyl anesthesia were studied."	3.68	Distribution, elimination, and action of vecuronium in the elderly. ( Diaz, J; Lien, CA; Matteo, RS; Ornstein, E; Schwartz, AE, 1991)
" Anesthesia was induced and maintained with 66% nitrous oxide in oxygen and alfentanil."	3.68	Pharmacodynamics of alfentanil. The role of plasma protein binding. ( Bovill, JG; Burm, AG; Gladines, MP; Hennis, PJ; Lemmens, HJ, 1992)
"This report describes methods for making repeated recordings from visual cortex in infant macaque monkeys (age range 5 weeks to 7 months) both under nitrous oxide anesthesia and in an alert behaving state."	3.68	Methods for repeated recording in visual cortex of anesthetized and awake behaving infant monkeys. ( Rodman, HR, 1991)
" Reproducible tce-MERs were recordable from the tibialis anterior muscle during nitrous oxide/opioid anesthesia in 11 patients."	3.68	Low concentrations of isoflurane abolish motor evoked responses to transcranial electrical stimulation during nitrous oxide/opioid anesthesia in humans. ( Drummond, JC; Kalkman, CJ; Ribberink, AA, 1991)
"To determine in infants and children the neuromuscular effect of pipecuronium during alfentanil-N2O/O2 anesthesia, the authors studied 32 ASA Physical Status 1 and 2 pediatric patients undergoing minor elective surgery, divided into three groups according to their age: group 1 included 12 infants, 1."	3.68	Neuromuscular effect of pipecuronium bromide in infants and children during nitrous oxide-alfentanil anesthesia. ( Gemperle, G; Morel, DR; Pittet, JF; Rouge, JC; Tassonyi, E, 1990)
"The effects of two levels of Saffan anesthesia (standard recording level: 2-4 mg/kg/min, and 10X recording level) and a single level of pentobarbital (5 mg/kg) on the power spectral density of efferent phrenic discharge were investigated in piglets aged from less than 1 day to 50 days."	3.68	Effects of anesthesia on efferent phrenic activity in neonatal swine. ( Cohen, HL; Condemi, G; Eberle, LP; Gandhi, MR; Gootman, PM; Sica, AL; Steele, AM, 1990)
"The effect of morphine, diazepam, N2O/O2 anesthesia on baroreflex control of heart rate in humans was investigated in this study."	3.67	Baroreceptor reflex control of heart rate during morphine sulfate, diazepam, N2O/O2 anesthesia in humans. ( Ebert, TJ; Kampine, JP; Kotrly, KJ; Roerig, DL; Vucins, EJ, 1984)
" In this paper, the authors report the effect of urethane anesthesia on the local cerebral glucose utilization."	3.67	[Alterations in local cerebral glucose utilization during various anesthesia--the effect of urethane and a review]. ( Ishii, S; Ito, M; Miyaoka, M, 1984)
"To test the possibility that mice selectively bred for resistance (HI mice) and susceptibility (LO mice) to nitrous oxide anesthesia have general differences in central nervous system sensitivity to other depressants, we examined the effects of four barbiturates in these two lines of mice."	3.67	Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia. ( Bainton, CR; Eger, EI; Koblin, DD; Lurz, FW; Nelson, NT; O'Connor, B, 1984)
"The neuromuscular and cardiovascular effects of mivacurium chloride (BW B1090U) were evaluated in 90 children (2-12 yr) during N2O:O2 halothane or N2O:O2 narcotic anesthesia."	3.67	Neuromuscular and cardiovascular effects of mivacurium in children. ( Alifimoff, JK; Eberly, C; Goudsouzian, NG; Griswold, J; McNulty, BF; Miler, V; Savarese, JJ; Smeets, R, 1989)
"The dose-response of pipecuronium bromide, the time course of its neuromuscular blocking effects, and the reversibility of the residual block by neostigmine and edrophonium have been investigated in patients undergoing various types of anesthesia."	3.67	Dose-response relation and time course of action of pipecuronium bromide in humans anesthetized with nitrous oxide and isoflurane, halothane, or droperidol and fentanyl. ( Agoston, S; Richardson, FJ; Wierda, JM, 1989)
"Eighty-one pediatric patients, ranging from neonates to adolescents, were studied during fentanyl-N2O-O2 anesthesia to determine for each of them the vecuronium infusion required to maintain 90-95% neuromuscular block (NMB)."	3.67	Vecuronium infusion requirements in pediatric patients during fentanyl-N2O-O2 anesthesia. ( Meretoja, OA, 1989)
"Vecuronium kinetics and dynamics were determined in five infants (3 to 11 months old) and five children (1 to 5 years old) during anesthesia with 70% nitrous oxide and 0."	3.67	Vecuronium kinetics and dynamics in anesthetized infants and children. ( Castagnoli, K; Fisher, DM; Miller, RD, 1985)
"In six dogs initially anesthetized with halothane-N2O-O2 for surgery and maintained during the experiment with high spinal anesthesia and local infiltration, diazepam 3."	3.67	Reversal of the cerebral effects of diazepam in the dog by the benzodiazepine antagonist Ro15-1788. ( Michenfelder, JD; Milde, JH; Roald, OK; Steen, PA, 1986)
"Effects of age on the pharmacodynamics of alfentanil, as a supplement to nitrous oxide anesthesia, were studied in younger (31-52 years; n = 14) and older (56-86 years; n = 14) women undergoing curative surgery for primary breast cancer."	3.67	Age has no effect on the pharmacodynamics of alfentanil. ( Bovill, JG; Burm, AG; Hennis, PJ; Lemmens, HJ, 1988)
"The purpose of this study was to evaluate neuromuscular and cardiovascular effects of doxacurium chloride, a new long-acting neuromuscular blocking agent, during a stable state of nitrous oxide and narcotic anesthesia."	3.67	The neuromuscular blocking and cardiovascular effects of doxacurium chloride in patients receiving nitrous oxide narcotic anesthesia. ( Abou-Donia, MM; Choi, WW; Forbes, RB; Gergis, SD; Mehta, MP; Murray, DJ; Rudd, GD; Sokoll, MD, 1988)
"8 to 25 kg), indirect calorimetry was used for the calculation of energy needs (E, kcal/h), fluid volume (FV, ml/h) and electrolyte requirements (sodium, Na+, and potassium, K+, mmol/liter per hour) during halothane anesthesia."	3.67	Energy expenditure and fluid and electrolyte requirements in anesthetized infants and children. ( Lindahl, SG, 1988)
" During both sedation with nitrous oxide or halothane anesthesia, Vf values using closed perfusion were similar to values previously reported using open perfusion."	3.67	Closed ventriculocisternal perfusion to determine CSF production rate and pressure. ( Artru, AA; Hornbein, TF, 1986)
"Nitrous oxide is often used as anesthesia during ophthalmic surgery that requires intraocular injection of sulfur hexafluoride gas or air."	3.67	Effect of nitrous oxide on gas bubble volume in the anterior chamber. ( Capuano, C; Hartung, J; Wolf, GL, 1985)
" When the ventilating gas was changed to nitrous oxide (N2O) 66%, balance oxygen, intraocular pressure increased from 14."	3.66	Nitrous oxide increases intraocular pressure after intravitreal sulfur hexafluoride injection. ( Capuano, C; Hartung, J; Wolf, GL, 1983)
"Arterial acid-base and selected physiologic measures of gopher snakes (Pituophis melanoleucus catenifer) during ketamine or halothane-nitrous oxide anesthesia were compared with base-line values."	3.66	Physiologic and acid-base measures of gopher snakes during ketamine or halothane-nitrous oxide anesthesia. ( Bush, M; Custer, RS, 1980)
"469 anesthetics for children were divided into 6 groups to investigate the possibility of oral or rectal administration of ketamine in comparison with intravenous or intramuscular injection and N2O:O2:halothane anesthesia."	3.66	[Smooth induction of anaesthesia in children by means of oral or rectal ketamine-dehydrobenzperidol application (author's transl)]. ( Cetina, J, 1982)
"The characteristics of phase II neuromuscular block following repeated intravenous injections of succinylcholine (SCh) were determined in 15 adult patients during enflurane, halothane, or fentanyl-nitrous oxide anesthesia."	3.66	Characteristics of succinylcholine-produced phase II neuromuscular block during enflurane, halothane, and fentanyl anesthesia. ( Hilgenberg, JC; Stoelting, RK, 1981)
" An enhancement of the indomethacin response during nitrous oxide anesthesia was mainly observed in structures which show a maintained or increased CBF during anesthesia."	3.66	Effect of indomethacin on local cerebral blood flow in awake, minimally restrained rats. ( Dahlgren, N; Ingvar, M; Siesjö, BK; Yokoyama, HJ, 1981)
"In our experience nitrous oxide-oxygen-morphine-curare anesthesia has proved preferable because of the need for swifly awakening patients after instrumentation to ascertain neurologic status."	3.66	Posterior spinal fusion with Harrington instrumentation using "balanced" anesthesia. ( Anderson, M, 1978)
"In dogs in neurolept-anesthesia the successive administration of alpha- and beta-adrenergic blocking agents and atropine, which should cause the functional equivalent of surgical denervation of the heart, always results in a marked tachycardia."	3.66	Incomplete cardiac vagal blockade with atropine in the anesthetized dog. ( Bennekers, JH; Brunsting, JR; Schuil, HA; Zijlstra, WG, 1979)
"The cardiovascular effects of halothane anesthesia in a mixture of nitrous oxide and oxygen were studied on piglets 7 hr to 25 days of age."	3.65	Age-dependent cardiovascular effects of halothane anesthesia in neonatal pigs. ( Crane, L; Gootman, N; Gootman, PM, 1975)
"Methoxyflurane has been used for general anesthesia at The Montreal Children's Hospital since its clinical introduction in 1960, and has been administered to more than 5000 patients undergoing most types of pediatric operations."	3.64	METHOXYFLURANE ANESTHESIA IN PEDIATRICS: A CLINICAL REPORT. ( DAVENPORT, HT; QUAN, P, 1964)
"Sevoflurane concentration was controlled to keep the bispectral index at approximately 50."	2.74	Landiolol, a new ultra-short-acting beta1-blocker, reduces anaesthetic requirement during sevoflurane/N(2)O/fentanyl anaesthesia in surgical patients. ( Ando, Y; Fujinaga, A; Fukusaki, M; Sumikawa, K; Tanabe, T; Terao, Y; Yamashita, K, 2009)
"Because the intensity of postoperative pain in end-stage kidney insufficiency patients can be modified by the type of received anaesthesia, it was decided to analyze the influence of standardized general anaesthesia on postoperative morphine consumption."	2.69	The influence of the type of anaesthesia on postoperative pain after kidney transplantation. ( Lazowski, T, 2000)
"Mivacurium infusion was modified at five-minute intervals in order to keep the height of the first twitch in TOF(T1) at 5% of its control value."	2.68	Dose-response relationships for edrophonium antagonism of mivacurium-induced neuromuscular block during N2O-enflurane-alfentanil anaesthesia. ( Drolet, P; Girard, M; Marcotte, J; Perreault, L, 1995)
"Desflurane is a new volatile anaesthetic with an extremely low blood/gas partition coefficient of 0."	2.68	[Awakening from anesthesia and recovery of cognitive function after desflurane or isoflurane]. ( Allhoff, T; Conzen, P; Loscar, M; Ott, E; Peter, K, 1996)
"Rewarming from hypothermia is often associated with an afterdrop (a further reduction in core temperature, despite cutaneous warming)."	2.67	Absence of nonshivering thermogenesis in anesthetized adult humans. ( Hynson, JM; McGuire, J; Moayeri, A; Sessler, DI, 1993)
"Postoperative pain was graded as strong, medium, mild, and painfree state."	2.66	[Anesthesia in patients with varicose syndrome]. ( Kujundzić, D; Zanić-Matanić, D, 1989)
"Single dose-response curves were determined for suxamethonium in neonates, infants and children during thiopentone-fentanyl-nitrous oxide anaesthesia."	2.66	Dose-response curves for suxamethonium in neonates, infants and children. ( Baker, RD; McKiernan, EP; Meakin, G; Morris, P, 1989)
"Alfentanil was given subsequently to two groups of patients: either as a bolus injection (n = 15) over 3 s, or as a slow injection (n = 15) over 30 s."	2.66	[Lung compliance in man is impaired by the rapid injection of alfentanyl]. ( Buhl, R; Freye, E; Hartung, E, 1986)
"Nitrous oxide can also inhibit major enzymatic pathways and repeated exposure may lead to neurologic damage."	2.44	Nitrous oxide in pediatric anesthesia: friend or foe? ( Baum, VC; Schmitt, EL, 2008)
"Sudden sensorineural hearing loss is infrequent, with an estimated incidence of 5 to 20 cases yearly per 100,000 people."	2.43	Unilateral sensorineural hearing loss after spine surgery: Case report and review of the literature. ( La Marca, F; Park, P; Smythe, P; Telian, SA; Toung, JS, 2006)
"Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia."	2.38	Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency. ( Flippo, TS; Holder, WD, 1993)
"Patients with G6PD deficiency are prone to develop haemolysis following any kind of oxidative stress and in ACM, there is a disturbed cranio-spinal pressure relationship."	1.43	G6PD Deficiency with Arnold-Chiari Malformation. ( Bhatia, PK; Sethi, P; Sharma, V; Singh, YR; Verma, S, 2016)
"Nitrous oxide was used in less than 10% of the centres, and 15% avoided neuromuscular block when neurophysiological monitoring was used during the surgery."	1.38	[Questionnaire on the anaesthesiology treatment of patients subjected to posterior fossa neurosurgery]. ( Badenes Quiles, R; Fábregas Juliá, N; Hernández Palazón, J; Honorato, C; Ingelmo Ingelmo, I; Rama-Maceiras, P; Romero Krauchi, O; Rubio Romero, R; Sánchez Ledesma, MJ; Valencia Sola, L, 2012)
"Nitrous oxide is an attractive agent for procedural sedation and analgesia in the emergency department; however, there are limited safety data for high-concentration continuous-flow nitrous oxide (50%-70%) and its use in young children."	1.35	High-concentration nitrous oxide for procedural sedation in children: adverse events and depth of sedation. ( Babl, FE; Barnett, P; Oakley, E; Seaman, C; Sharwood, LN, 2008)
"Congenital nasolacrimal duct obstruction affects more than 6% of newborns."	1.34	[Use of MEOPA during nasolacrimal duct probing in children]. ( Lala-Gitteau, E; Majzoub, S; Pisella, PJ, 2007)
"The duration of seizure activity was longer in sevoflurane patients, 35 (17."	1.32	Anaesthesia for electroconvulsive therapy: a comparison of sevoflurane with propofol. ( Dawson, P; Hodgson, RE; Hold, AR; Rout, CC; Zuma, K, 2004)
"Buprenorphine and flunixin were given before and after surgery, and the wound margin was infiltrated with 0."	1.30	Anaesthesia for lambs undergoing spinal surgery: a case series. ( Clutton, RE; Funnell, OD; Murison, PJ, 1998)
" The elimination half-life was long in both groups (90."	1.29	The effects of halothane and nitrous oxide on the pharmacokinetics of propofol in dogs. ( Grant, S; Nolan, AM; Reid, J, 1993)
" Neuromuscular function was recorded by adductor pollicis emg and a cumulative log-probit dose-response curve of rocuronium was established."	1.29	Rocuronium in infants, children and adults during balanced anaesthesia. ( Erkola, O; Juvakoski, M; Meretoja, OA; Rautoma, P; Taivainen, T, 1996)
"Thiopental was "trapped" during the early distribution phase to a considerable extent in the vessel-rich tissues of rats simultaneously anesthetized with halothane; this pharmacokinetic interaction might be explained hemodynamically: in many tissues regional blood flow is reduced by halothane; thereby a delayed "washout" of thiopental from the vessel-rich tissues could take place and redistribution would be delayed; additional factors as e."	1.28	Increase of thiopental concentration in tissues of the rat due to an anesthesia with halothane. ( Altmayer, P; Büch, HP; Büch, U; Isenberg, JC, 1991)
" Guaifenesin amplifies the effect of several anaesthetics, which complement one another, allowing the dosage to be decreased and thereby reducing the cardiovascular stress."	1.28	[Combination anesthesia in sheep with ketamine-(fentanyl)-guaifenesin (My 301)-laughing gas-halothane]. ( Blättchen, C; Blümel, G; Brosch, W; Erhardt, W; Roder, J; Schindele, M, 1990)
"Mivacurium was initially administered as a single bolus in doses from 0."	1.28	Neuromuscular and cardiovascular effects of mivacurium chloride in surgical patients receiving nitrous oxide-narcotic or nitrous oxide-isoflurane anaesthesia. ( Abou-Donia, M; Choi, WW; Forbes, RB; Gergis, SD; Kirchner, J; Mehta, MP; Murray, DJ; Sokoll, MD, 1989)
"2."	1.28	Disposition of alfentanil in patients receiving a renal transplant. ( Bower, S; Sear, JW, 1989)
"Cats were given systemically the anticholinesterase paraoxon at a dosage (3 mg/kg i."	1.28	Persistence of central respiratory rhythmogenesis after maximal acetylcholinesterase inhibition in unanaesthetized cats. ( Delamanche, IS; Denavit-Saubié, M; Foutz, AS, 1989)
" The N2O dosage affected on the migration of PMNs to the cornea."	1.27	Suppression of chemotaxis to corneal inflammation by nitrous oxide. ( Kripke, BJ; Kupferman, A; Luu, KC, 1987)
"A case of malignant hyperthermia during isoflurane anaesthesia without the use of muscle relaxants in a healthy 7-year-old girl is presented."	1.27	Malignant hyperthermia during isoflurane anaesthesia. A case report. ( Johannesson, G; Rogstadius, J; Veel, T, 1987)
"Chloroform was used in St."	1.26	The early history of anaesthesia in Newfoundland. ( Wright, DJ, 1979)
"The relatives of a patient who died from malignant hyperpyrexia were examined clinically and biochemically."	1.25	Malignant hyperpyrexia: Investigation of a family after a fatal case. ( Appleyard, TN; Ryan, DW, 1975)

Research

Studies (1,143)

Authors

Clinical Trials (24)

Trial Overview

Trial Outcomes

Cardiac Arrest

Hospital Stay (Days)

Myocardial Infarction (MI)

Pulmonary Embolism

Stroke

The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.

Wound Infection

Change in Plasma Total Homocysteine Concentration (tHcy)

Timeframe	Studies, this research(%)	All Research%
pre-1990	910 (79.62)	18.7374
1990's	114 (9.97)	18.2507
2000's	64 (5.60)	29.6817
2010's	41 (3.59)	24.3611
2020's	14 (1.22)	2.80

Authors	Studies
Chan, CS	2
Chan, MTV	2
Hönemann, C	1
Kim, SC	2
Daras, C	1
Miao, M	1
Han, Y	1
Zhang, Y	1
Xu, Y	1
Zhang, L	1
Yang, Y	1
Sun, M	1
Zhang, J	1
Coveney, J	1
Khan, U	1
Beattie, T	1
Habibullah, AK	1
Hoque, MF	1
Jahan, MS	1
Alim, A	1
Rahman, MR	1
Banik, D	1
Fernández-Cantalejo Padial, J	1
Heras, E	1
Hernández, B	1
Jiménez, AB	1
Martínez, A	1
López-Herce, J	1
Mencía, S	1
Trombetta, A	1
Cossovel, F	1
Grasso, DL	1
Barbi, E	1
Strätling, MWM	1
Joo, SS	1
Bechtold, H	1
Jaffe, RA	1
Brock-Utne, JG	2
Souza, KM	1
De Vivo, I	1
Chen, CY	1
Nogueira, FR	1
Aun, AG	1
Arruda, NM	1
Lara, JR	1
Silva, MAP	1
Figueiredo, DBS	1
Corrêa, CR	1
de Carvalho, LR	1
Braz, JRC	1
Braz, LG	1
Braz, MG	1
Saito, H	1
Kambayashi, R	1
Hagiwara-Nagasawa, M	1
Nunoi, Y	1
Goto, A	1
Izumi-Nakaseko, H	1
Kawai, S	1
Takei, Y	1
Matsumoto, A	1
Hoshiai, K	1
Akie, Y	1
Sugiyama, A	1
Patel, KK	1
Sun, X	1
Cheng, J	1
Schaller, K	1
Tessitore, E	1
Gondar, R	1
Gaudet, J	1
Myles, PS	4
Leslie, K	4
Nouri, A	1
Kohtala, S	1
Rantamäki, T	1
Lilitsis, E	1
Astyrakaki, E	1
Blevrakis, E	1
Xenaki, S	1
Chalkiadakis, G	1
Chrysos, E	1
Mashari, A	1
Wasowicz, M	1
Lakhe, G	1
Sharma, SM	1
Shin, CH	1
Alston, TA	1
Zafirova, Z	1
Sheehan, C	1
Hosseinian, L	1
Rizvanović, N	1
Čaušević, S	1
Hrnčić, N	1
Hatibović, H	1
Scotland, T	1
Kumakura, S	1
Yamaguchi, K	1
Sugasawa, Y	1
Murakami, T	1
Kikuchi, T	1
Inada, E	1
Nagaoka, I	1
Parida, S	1
Badhe, AS	1
Enekvist, B	1
Johansson, A	1
Desai, MS	1
Desai, SP	1
Kasahara, M	1
Ichinohe, T	1
Okamoto, S	1
Okada, R	1
Kanbe, H	1
Matsuura, N	1
Ramanadham, SR	1
Costa, CR	1
Narasimhan, K	1
Coleman, JE	1
Rohrich, RJ	1
Borghi, L	1
Rosenbloom, JM	1
Schonberger, RB	1
Cascella, M	1
Cascella, MM	1
Arcamone, M	1
Arcamone, MM	1
Morelli, E	1
Morelli, EE	1
Viscardi, D	1
Viscardi, DD	1
Russo, V	1
Russo, VV	1
De Franciscis, S	1
De Franciscis, SS	1
Belli, A	1
Belli, AA	1
Accardo, R	1
Accardo, RR	1
Caliendo, D	1
Caliendo, DD	1
De Luca, E	1
De Luca, EE	1
Di Caprio, B	1
Di Caprio, BB	1
Di Sauro, F	1
Di Sauro, FF	1
Giannoni, G	1
Giannoni, GG	1
Iermano, C	1
Iermano, CC	1
Maciariello, M	1
Maciariello, MM	1
Marracino, M	1
Marracino, MM	1
Cuomo, A	1
Cuomo, AA	1
Smits, GJP	1
Thijssen, WAMH	1
Pain, S	1
Doger, C	1
Kahveci, K	1
Ornek, D	1
But, A	1
Aksoy, M	1
Gokcinar, D	1
Katar, D	1
Hoffmann, U	1
Sheng, H	2
Ayata, C	1
Warner, DS	3
Chan, MT	2
Peyton, PJ	1
Buckley, N	1
Kasza, J	1
Paech, MJ	3
Beattie, WS	1
Sessler, DI	3
Forbes, A	1
Wallace, S	1
Chen, Y	1
Tian, Y	1
Wu, WK	1
Verma, S	1
Bhatia, PK	1
Sharma, V	1
Sethi, P	1
Singh, YR	1
Pesa, NL	1
Bause, GS	1
Mahajan, R	1
Gupta, R	1
Sharma, A	1
Taivainen, T	3
Klockars, J	1
Hiller, A	2
Wennervirta, J	1
van Gils, MJ	1
Suominen, P	1
Mraovic, B	1
Simurina, T	1
Sonicki, Z	1
Skitarelic, N	1
Gan, TJ	2
VIGNE, J	1
RAPIN, M	3
CHERRY, H	2
PALLIN, IM	2
FLORCKEN, H	1
SONNENSCHEIN, RR	1
JAMISON, R	1
KRAFT, KA	1
MOSS, AA	2
URRY, A	1
MECCA, AS	1
FAUVET, E	1
SCHULTZ, H	1
WILLINGER, L	2
HUDSON, MP	1
WYRICK, W	1
VINING, JA	1
SMITH, C	1
HINGSON, RA	1
EDWARDS, WB	1
BRODY, J	1
Ali, Z	1
Prabhakar, H	1
Bithal, PK	2
Dash, HH	1
Tanabe, T	1
Fukusaki, M	1
Fujinaga, A	1
Ando, Y	1
Yamashita, K	1
Terao, Y	1
Sumikawa, K	2
Golan, G	1
Tighe, P	1
Dobija, N	1
Perel, A	1
Keidan, I	1
Nagele, P	1
Zeugswetter, B	1
Eberle, C	1
Hüpfl, M	1
Mittlböck, M	1
Födinger, M	1
Eberspächer, E	1
Eckel, B	1
Engelhard, K	1
Müller, K	1
Hoffman, WE	2
Blobner, M	2
Werner, C	1
Ellett, AE	1
Shields, JC	1
Ifune, C	1
Roa, N	1
Vannucci, A	1
Sanders, RD	1
Maze, M	2
SELDIN, HM	2
HAWKINSON, O	1
BURGMAYER, J	1
WELLS, ER	2
SEARLES, PW	1
HENRY, P	1
BOURNE, JG	3
CLEMENT, FW	3
CLARKE, LT	1
BARNARD, RD	1
NEFF, W	2
MAYER, EC	1
de la LUZ PERALES, M	1
ROVENSTINE, EA	1
SCHOTZ, S	3
MULCAHY, LL	1
HARRIS, L	1
CONROY, WA	2
BACHRACH, EH	1
JOHNSON, WP	1
Mayhew, JF	1
López-Valverde, A	1
Montero, J	1
Albaladejo, A	1
Gómez de Diego, R	1
TYLER, EA	1
HUDSON, F	1
CLAUDEL, M	1
HOLADAY, DA	1
MURTAGH, BL	1
BARTON, GD	1
WICKS, WR	1
LIVINGSTONE, HM	1
KNIGHT, RT	1
OULLIBER, VJ	1
HARROUN, P	1
BECKERT, FE	1
HATHAWAY, HR	1
Perouansky, M	1
Rau, V	1
Ford, T	1
Oh, SI	1
Perkins, M	1
Eger, EI	7
Pearce, RA	1
Zhou, ZW	1
Shu, Y	1
Li, M	1
Guo, X	1
Pac-Soo, C	1
Ma, D	1
Constantinides, C	2
Mean, R	2
Janssen, B	1
Theerapongpakdee, S	1
Bunsangjaroen, P	1
Horatanaruang, D	1
Phanpanusit, T	1
Asava-aree, C	1
Uppan, K	1
Janssen, BJ	1
Graham, AM	1
Peyton, P	2
El Dawlatly, AA	1
Rajkumar, A	1
Bajekal, R	1
Onuki, K	1
Onuki, N	1
Imamura, T	1
Yamanishi, Y	1
Yoshikawa, S	1
Hagihira, S	1
Shimada, J	1
Nagasaka, H	1
Kavanagh, T	1
Buggy, DJ	1
Gauberti, M	1
Obiang, P	1
Guedin, P	1
Balossier, A	1
Gakuba, C	1
Diependaele, AS	1
Chazalviel, L	1
Vivien, D	1
Young, AR	1
Agin, V	1
Orset, C	1
Dhany, AL	1
Mitchell, T	1
Foy, C	1
Ingelmo Ingelmo, I	1
Fábregas Juliá, N	1
Rama-Maceiras, P	1
Rubio Romero, R	1
Badenes Quiles, R	1
Valencia Sola, L	1
Romero Krauchi, O	1
Honorato, C	1
Hernández Palazón, J	1
Sánchez Ledesma, MJ	1
van Zundert, T	1
Brimacombe, J	2
Zhou, ZJ	1
Wang, X	1
Zheng, S	1
Zhang, XF	1
Duthie, DJ	1
Inoue, S	1
Kawaguchi, M	1
Kakimoto, M	1
Sakamoto, T	1
Kitaguchi, K	1
Furuya, H	1
Morimoto, T	1
Sakaki, T	1
Hong, JY	1
Oh, JI	1
Kim, SM	1
Plaud, B	1
Debaene, B	1
Donati, F	2
Shibukawa, K	1
Kawamata, M	1
Seki, S	1
Narimatsu, E	1
Namiki, A	2
Choi, JC	1
Yoon, KB	1
Um, DJ	1
Kim, C	1
Kim, JS	1
Lee, SG	1
Lin, CY	1
Pypendop, BH	1
Ilkiw, JE	2
Imai, A	1
Bolich, JA	1
FRUMIN, MJ	4
RACKOW, H	3
VAN NOUHUYS, F	1
SHANE, SM	1
ASHMAN, H	1
FOLDES, FF	7
CERAVOLO, AJ	1
CARPENTER, SL	1
BRIASCO, G	1
RADEMAKER, GG	1
BROWN, AK	1
EICHENBERGER, F	1
GORDONOFF, T	1
HELD, AJ	3
VONOW, P	5
MATTER, J	1
ERIKSSON, SG	1
PALAZZI, S	2
NEYROUD, M	1
WALCH, E	1
RIEHM, H	1
MORRIS, LE	1
SCHILLING, EA	1
FREDERICKSON, EL	1
Singer, H	1
VOSS, W	1
FORSSELL, C	1
GOTHMAN, B	1
EISAMAN, JL	1
CAYLOR, HD	1
JACKSON, CE	1
ROE, H	1
RUBEN, H	6
WOLFERS, P	1
ANMELAVA, NV	1
DLHOS, E	1
SCHMID-SCHMIDSFELDEN, O	1
HAMPEL, K	1
MOHELSKY, HM	1
SCHON, F	2
BERGQUIST, K	1
LUNDIN, S	1
THOREN, L	1
JOHANSEN, S	1
PRESTON, FS	1
COURVILLE, CB	1
SANCHEZ-PEREZ, JM	1
AMYES, EW	1
GOLDEN, AA	2
FINOTTI, A	1
COHEN, EN	1
PAULSON, WJ	1
WALL, J	1
ELERT, B	1
DUNNOM, WR	1
LICHTENSTEIN, ME	1
METHOD, H	1
WOLF, H	2
BASSI, M	1
DE CARO, PA	1
CREHAN, A	1
KUNZ, T	1
IMO, K	1
GRIESSER, G	1
BOZZA, M	1
ZETZMANN, M	2
STEIN, ML	1
TRACKSDORF, H	3
FUCHS, E	1
NUCKEL, H	1
EYMERI, M	1
COLEMAN, F	1
MOIR, LJ	1
SERGEEV, AV	2
SKINHOJ, E	1
SEVERINGHAUS, JW	1
KRUEGER-JANSON, CE	2
FINK, BR	2
BERGNER, RP	1
HERD, RM	1
KLINE, K	1
LAWRENCE, D	1
HUTTON, CE	1
SIKER, ES	4
PAHK, NM	2
SWERDLOW, M	4
BLITZER, MH	1
DOUGLAS, MH	1
WALL, W	1
WEBER, HJ	1
GREENWALD, L	1
EDMUNDS, F	1
HAUBRICK, T	1
GRAY, J	1
PARAISO, A	1
ROSSELLO, S	1
HARMS, BH	1
FRANK, H	1
HAMILTON, WK	2
CULLEN, SC	4
WEAVER, RH	1
VIRTUE, RW	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effect of Minimal Flow Sevoflurane Anesthesia on Blood Gas Analysis and Hemodynamic Parameters in Laparoscopic Cholecystectomies, a Randomised Controlled Trial.[NCT04813952]		70 participants (Actual)	Interventional	2021-02-15	Completed
Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).[NCT00430989]	Phase 4	7,112 participants (Actual)	Interventional	2007-04-30	Completed
Effect of Dexmedetomidine as Anesthetic Coadjuvant on Plasmatic Cortisol Response in Transsphenoidal Surgery for Pituitary Tumors[NCT02549768]	Phase 4	40 participants (Anticipated)	Interventional	2015-09-30	Recruiting
A Prospective, Randomized Controlled Study to Compare the Effect of Sevoflurane and Propofol for Maintenance of Anesthesia on Postoperative Recovery After Transsphenoidal Resection of Pituitary Adenoma[NCT05822817]	Phase 4	252 participants (Anticipated)	Interventional	2023-05-03	Recruiting
The Effect of Dream Doctors in Children Undergoing Digestive Endoscopic Procedures: Physiological and Biological Assessment of Emotional and Cognitive Consequences[NCT02668679]		99 participants (Actual)	Interventional	2016-03-30	Completed
Can Medical Clowns Prevent the Usage of Sedation During the Performance of EEG in Young Children[NCT05257096]		100 participants (Anticipated)	Interventional	2019-05-01	Recruiting
Influence of Preoperative Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia[NCT00901394]		63 participants (Actual)	Interventional	2009-03-31	Completed
Influence of the MTHFR 677C>T Mutation on Homocysteine Levels After Nitrous Oxide Anesthesia.[NCT00482456]	Phase 4	140 participants (Actual)	Interventional	2005-01-31	Completed
Shortening of the Twitch Stabilization Period by Tetanic Stimulation in Acceleromyography in Children and Young Adults[NCT02552875]	Phase 4	80 participants (Actual)	Interventional	2014-09-30	Completed
Efficiency of Preoxygenation in Obese Patients: Evaluation of Traditional Method Versus Pressure Assisted Preoxygenation.[NCT00673634]		30 participants (Actual)	Interventional	2008-03-31	Completed
The Efficacy and Tolerability of Different Levels of Inspiratory Support and PEEP During Preoxygenation. A Randomized Controlled Trial.[NCT00922753]		20 participants (Actual)	Interventional	2007-02-28	Completed
Addition of Nitrous Oxide to a Sevoflurane or Propofol Based Anesthetic and Its Effects on Depth of Anesthesia Indices (N20)[NCT00717574]		32 participants (Actual)	Interventional	2008-03-31	Completed
Evaluation of Nitrous Oxide In the Gas Mixture for Anaesthesia: a Randomised Controlled Trial[NCT00164047]	Phase 4	2,070 participants (Anticipated)	Interventional	2003-04-30	Completed
Comparison of Desflurane Balanced Anesthesia Versus TIVA-TCI (Total IntraVenous Anesthesia-Target Controlled Infusion) in Patients Undergoing Ophthalmic Ambulatory Surgery: A Single Center, Prospective, Randomized, Controlled Study[NCT02922660]		209 participants (Actual)	Interventional	2016-10-31	Completed
Comparative Study Between Combined General Anesthesia With Peribulbar Block Versus Traditional General Anesthesia in Patients Undergoing Strabismus Surgery[NCT04549844]	Phase 4	70 participants (Anticipated)	Interventional	2019-08-14	Recruiting
Reducing Intra-operative Pressure Variations in Paediatric Microcuff Endotracheal Tube Cuffs[NCT03240354]		49 participants (Actual)	Interventional	2018-08-06	Completed
Opioid Free Versus Opioid Balanced Anesthesia in Middle Ear Surgery.[NCT03809949]	Phase 4	60 participants (Actual)	Interventional	2019-01-16	Completed
Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy: a Prospective, Randomized, Controlled Clinical Study[NCT05779176]		252 participants (Anticipated)	Interventional	2023-05-01	Not yet recruiting
Longitudinal Assessment of Neurological Recovery in Patients Following Nitrous Oxide Abuse[NCT05714917]		100 participants (Anticipated)	Observational	2023-04-01	Not yet recruiting
The Effect of Different Concentrations of Sevoflorane on Intraocular Pressure in Children Undergoing Ocular Surgery Under General Anesthesia[NCT01248689]		21 participants (Anticipated)	Interventional	2011-02-28	Not yet recruiting
Endotracheal Tube Cuff Pressure Protocol to Reduce Dysphagia Following Anterior Cervical Spine Surgery: A Prospective Randomized Pilot Study[NCT00332683]		40 participants (Actual)	Interventional	2006-06-06	Completed
Changes in the Cuff Pressure in Infants in the Absence of Nitrous Oxide[NCT03088761]		20 participants (Anticipated)	Observational	2017-05-01	Not yet recruiting
Study of the Effect of Intraoperative Positive Messages on Postoperative Outcomes[NCT02765750]		5 participants (Actual)	Interventional	2016-03-31	Terminated (stopped due to The primary investigator was transferred to another hospital)
Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779]		12 participants (Actual)	Observational	2017-08-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	15
N2O Free Group (FiO2 0.3)	19

Intervention	Days (Median)
Nitrous Oxide: 70% N2O (FiO2 0.3)	6.1
N2O Free Group (FiO2 0.3)	6.1

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	215
N2O Free Group (FiO2 0.3)	219

Intervention	participants (Number)
N2O Group (FiO2 0.3)	18
N2O Free Group (FiO2 0.3)	22

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	26
N2O Free Group (FiO2 0.3)	19

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	283
N2O Free Group (FiO2 0.3)	296

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	321
N2O Free Group (FiO2 0.3)	311

"Difference between baseline (pre-operative) and peak postoperative (i.e., maximum of postoperative value obtained within 30 minutes after anesthesia end time and morning of post-operative day 1) tHcy concentration .~Of note: there were no secondary outcomes." (NCT00901394)
Timeframe: Immediately postoperatively and on postoperative day 1

The Effect of Nitrous Oxide on Bispectral Index (BIS) and State Entropy Index (SE)

Intervention	mcmol/L (Median)
Treatment 1	1.9
Treatment 2	2.7
Control Group	0.5

"We planned this study to compare the effect of adding N2O on BIS and SE during an intravenous or an inhalation anesthetic. We hypothesized that neither BIS nor SE would decrease in response to the addition of N2O to a Propofol anesthetic. We also hypothesized that neither BIS nor SE would decrease in participants under Sevoflurane anesthesia if the inspired concentration of Sevoflurane were carefully and continuously adjusted to maintain a constant end-tidal concentration during the addition and discontinuation of N2O.~BIS (0-100) and SE (0-92) are unitless, ordinal indices of anesthetic depth. Both indices are decreased when the depth of anesthesia is increased." (NCT00717574)
Timeframe: From baseline to 20 minutes after the addition of 60% nitrous oxide

Article	Year
Epileptiform EEG discharges during sevoflurane anesthesia in children: A meta-analysis. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2022, Volume: 143 Topics: Anesthesia; Anesthetics, Inhalation; Child; Electroencephalography; Humans; Methyl Ethers; Nitrous O	2022
Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia. Basic & clinical pharmacology & toxicology, 2021, Volume: 129, Issue:2 Topics: Anesthesia; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Depr	2021
Anesthetic management of a pediatric patient with Electron Transfer Flavoprotein Dehydrogenase deficiency (ETFDH) and acute appendicitis: case report and review of the literature. BMC anesthesiology, 2017, Aug-29, Volume: 17, Issue:1 Topics: Acute Disease; Anesthesia; Appendicitis; Child; Drug Therapy, Combination; Female; Fentanyl; Humans;	2017
Update on nitrous oxide and its use in anesthesia practice. Best practice & research. Clinical anaesthesiology, 2018, Volume: 32, Issue:2 Topics: Anesthesia; Anesthesiology; Anesthetics, Inhalation; Female; Humans; Labor Pain; Nitrous Oxide; Preg	2018
Response of the Australian Medical Services to restoration of mobile warfare on the Western Front in 1918 (part II). ANZ journal of surgery, 2019, Volume: 89, Issue:10 Topics: Amputation, Surgical; Anesthesia; Australia; Blood Transfusion; History, 19th Century; History, 20th	2019
Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature. Journal of medical case reports, 2015, Aug-20, Volume: 9 Topics: Aged; Anesthesia; Anesthesia, Inhalation; Colorectal Neoplasms; Homocystinuria; Humans; Male; Methyl	2015
Anesthesia in Experimental Stroke Research. Translational stroke research, 2016, Volume: 7, Issue:5 Topics: Anesthesia; Anesthetics; Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Anima	2016
Can anaesthetic technique effect postoperative outcome? Current opinion in anaesthesiology, 2012, Volume: 25, Issue:2 Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Transfusion; Cognition Disorders; Humans; Ne	2012
Anaesthetic agents for thoracic surgery: what's best? Current opinion in anaesthesiology, 2013, Volume: 26, Issue:1 Topics: Anesthesia; Anesthetics; Anesthetics, Inhalation; Animals; Cognition Disorders; Humans; Immune Syste	2013
A review of the risks and benefits of nitrous oxide in current anaesthetic practice. Anaesthesia and intensive care, 2004, Volume: 32, Issue:2 Topics: Anemia, Megaloblastic; Anesthesia; Anesthetics, Inhalation; Homocysteine; Humans; Hypoxia; Immunosup	2004
Unilateral sensorineural hearing loss after spine surgery: Case report and review of the literature. Surgical neurology, 2006, Volume: 66, Issue:4 Topics: Adrenal Cortex Hormones; Anesthesia; Audiometry; Decompression, Surgical; Ear, Inner; Early Diagnosi	2006
Nitrous oxide in pediatric anesthesia: friend or foe? Current opinion in anaesthesiology, 2008, Volume: 21, Issue:3 Topics: Anesthesia; Anesthetics, Inhalation; Brain; Humans; Nitrous Oxide; Pediatrics; Polymorphism, Single	2008
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[Nitrogen protoxide in neuro-anesthesia]. Minerva anestesiologica, 1988, Volume: 54, Issue:6 Topics: Anesthesia; Animals; Humans; Nitrous Oxide	1988
The coronary circulation and myocardial oxygenation in coronary artery disease: effects of anesthesia. Anesthesia and analgesia, 1986, Volume: 65, Issue:4 Topics: Anesthesia; Calcium Chloride; Coronary Artery Bypass; Coronary Circulation; Coronary Disease; Digoxi	1986
Anesthetic management of the patient with hyperthyroidism. Anesthesiology, 1974, Volume: 41, Issue:6 Topics: Adrenal Cortex Hormones; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Sp	1974
Anaesthesia in the presence of liver disease and for hepatic transplantation. British journal of anaesthesia, 1972, Volume: 44, Issue:9 Topics: Acid-Base Equilibrium; Anesthesia; Blood Circulation; Blood Coagulation; Blood Glucose; Body Tempera	1972
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Anaesthesia and carbohydrate metabolism. British journal of anaesthesia, 1973, Volume: 45, Issue:3 Topics: Acidosis; Anesthesia; Anesthetics; Animals; Bicarbonates; Blood Glucose; Carbohydrate Metabolism; Ca	1973
Effect of anesthesia on myocardial tolerance to ischemia. International anesthesiology clinics, 1974,Spring, Volume: 12, Issue:1 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthesia; Anesthetics; Ani	1974
Effect of anesthetic agents on cardiovascular function and cardiac rhythm. The Veterinary clinics of North America, 1973, Volume: 3, Issue:1 Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Blood Pressure; C	1973
[Pheochromocytoma and anesthesia]. Masui. The Japanese journal of anesthesiology, 1974, Volume: 23, Issue:3 Topics: Adrenal Gland Neoplasms; Anesthesia; Blood Volume; Catecholamines; Halothane; Humans; Methoxyflurane	1974
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Anaesthesia in irreversible renal failure. Guy's Hospital reports, 1970, Volume: 119, Issue:3 Topics: Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Local; Anesthesia, Spinal; Bloo	1970
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Article	Year
Safety of Nitrous Oxide Anesthesia in a Selected Group of Patients Undergoing Neurosurgery: An Exploratory Subgroup Analysis of the ENIGMA Trials. Journal of neurosurgical anesthesiology, 2022, Jul-01, Volume: 34, Issue:3 Topics: Anesthesia; Anesthetics, Inhalation; Humans; Neurosurgery; Nitrous Oxide; Postoperative Complication	2022
Effect of intracuff alkalinized 2% lidocaine on endotracheal tube cuff pressure and postoperative throat symptoms in anaesthesia maintained by nitrous oxide. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2019, Feb-01, Volume: 16, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics; Double-Blind Method; Female; Humans; Intubation, Intratracheal	2019
Effects of nitrous oxide on the production of cytokines and chemokines by the airway epithelium during anesthesia with sevoflurane and propofol. Molecular medicine reports, 2013, Volume: 8, Issue:6 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Body Fluids; Chemokines; Female; Humans; Interleuk	2013
Comparison of cognitive, ambulatory, and psychomotor recovery profiles after day care anesthesia with propofol and sevoflurane. Journal of anesthesia, 2014, Volume: 28, Issue:6 Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalati	2014
Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery. BioMed research international, 2016, Volume: 2016 Topics: Abdomen; Adult; Anesthesia; Arterial Pressure; Carbon Dioxide; Cholecystectomy; Female; Heart Rate;	2016
Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial. British journal of anaesthesia, 2016, Volume: 117, Issue:6 Topics: Aged; Aged, 80 and over; Anesthesia; Anesthetics, Inhalation; Chronic Pain; Female; Hong Kong; Human	2016
The performance of Bispectral Index in children during equi-MAC halothane vs. sevoflurane anaesthesia. European journal of anaesthesiology, 2008, Volume: 25, Issue:11 Topics: Adolescent; Anesthesia; Anesthesia Recovery Period; Anesthesiology; Anesthetics, Inhalation; Child;	2008
The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study. Anesthesia and analgesia, 2008, Volume: 107, Issue:3 Topics: Adult; Aged; Anesthesia; Dose-Response Relationship, Drug; Female; Gynecologic Surgical Procedures;	2008
Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques. Journal of neurosurgical anesthesiology, 2009, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics,	2009
Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques. Journal of neurosurgical anesthesiology, 2009, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics,	2009
Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques. Journal of neurosurgical anesthesiology, 2009, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics,	2009
Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques. Journal of neurosurgical anesthesiology, 2009, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics,	2009
Landiolol, a new ultra-short-acting beta1-blocker, reduces anaesthetic requirement during sevoflurane/N(2)O/fentanyl anaesthesia in surgical patients. European journal of anaesthesiology, 2009, Volume: 26, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anesthesia; Anesthetics; Female; Fentanyl; Hip	2009
Clowns for the prevention of preoperative anxiety in children: a randomized controlled trial. Paediatric anaesthesia, 2009, Volume: 19, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Doubl	2009
Clowns for the prevention of preoperative anxiety in children: a randomized controlled trial. Paediatric anaesthesia, 2009, Volume: 19, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Doubl	2009
Clowns for the prevention of preoperative anxiety in children: a randomized controlled trial. Paediatric anaesthesia, 2009, Volume: 19, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Doubl	2009
Clowns for the prevention of preoperative anxiety in children: a randomized controlled trial. Paediatric anaesthesia, 2009, Volume: 19, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Doubl	2009
Pentazocine increases bispectral index without surgical stimulation during nitrous oxide-sevoflurane anesthesia. Journal of anesthesia, 2011, Volume: 25, Issue:6 Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Consciousness	2011
Comparison of cuff-pressure changes in silicone and PVC laryngeal masks during nitrous oxide anaesthesia in spontaneously breathing children. Anaesthesiology intensive therapy, 2012, Aug-08, Volume: 44, Issue:2 Topics: Adolescent; Anesthesia; Child; Child, Preschool; Female; Humans; Infant; Laryngeal Masks; Male; Nitr	2012
Amplitudes and intrapatient variability of myogenic motor evoked potentials to transcranial electrical stimulation during ketamine/N2O- and propofol/N2O-based anesthesia. Journal of neurosurgical anesthesiology, 2002, Volume: 14, Issue:3 Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Electric Stimulation; Evoked Potentia	2002
Comparison of sevoflurane-nitrous oxide and target-controlled propofol with fentanyl anesthesia for hysteroscopy. Yonsei medical journal, 2002, Volume: 43, Issue:4 Topics: Adult; Anesthesia; Anesthetics; Female; Fentanyl; Hemodynamics; Humans; Hysteroscopy; Methyl Ethers;	2002
Duration of anesthesia before muscle relaxant injection influences level of paralysis. Anesthesiology, 2002, Volume: 97, Issue:3 Topics: Adult; Anesthesia; Anesthetics, Inhalation; Female; Humans; Isoquinolines; Male; Middle Aged; Mivacu	2002
Intravenous magnesium sulfate administration reduces propofol infusion requirements during maintenance of propofol-N2O anesthesia: part I: comparing propofol requirements according to hemodynamic responses: part II: comparing bispectral index in control a Anesthesiology, 2002, Volume: 97, Issue:5 Topics: Adult; Anesthesia; Blood Pressure; Electroencephalography; Female; Heart Rate; Humans; Magnesium Sul	2002
Hemodynamic effects of nitrous oxide in isoflurane-anesthetized cats. American journal of veterinary research, 2003, Volume: 64, Issue:3 Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cats; Dose-Response Relationship, Drug; Hemodynamics;	2003
Entropy of EEG during anaesthetic induction: a comparative study with propofol or nitrous oxide as sole agent. British journal of anaesthesia, 2004, Volume: 92, Issue:2 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Dose-Response Relationsh	2004
Spectral entropy monitoring is associated with reduced propofol use and faster emergence in propofol-nitrous oxide-alfentanil anesthesia. Anesthesiology, 2005, Volume: 103, Issue:2 Topics: Adult; Aged; Alfentanil; Anesthesia; Entropy; Female; Humans; Male; Middle Aged; Nitrous Oxide; Prop	2005
Comparison of the anesthesia profiles between sevoflurane-nitrous oxide and propofol-nitrous oxide conveyed by laryngeal mask airway in patients undergoing ambulatory gynecological surgery. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2006, Volume: 44, Issue:2 Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Female; Gynecologic Surgical Procedures; Humans;	2006
Association of oculocardiac reflex and postoperative nausea and vomiting in strabismus surgery in children anesthetized with halothane and nitrous oxide. Paediatric anaesthesia, 2006, Volume: 16, Issue:9 Topics: Anesthesia; Anesthetics; Arrhythmias, Cardiac; Bradycardia; Child; Child, Preschool; Female; Halotha	2006
Propofol and remifentanil for deep sedation in children undergoing gastrointestinal endoscopy. Paediatric anaesthesia, 2007, Volume: 17, Issue:5 Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Child; Child, Prescho	2007
The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children. Paediatric anaesthesia, 2007, Volume: 17, Issue:6 Topics: Adolescent; Anesthesia; Anesthetics, Inhalation; Arrhythmias, Cardiac; Child; Child, Preschool; Desf	2007
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The effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide. Veterinary anaesthesia and analgesia, 2008, Volume: 35, Issue:5 Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Inhalation; Animals; Dogs; Drug Interactions; Fem	2008
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Is nitrous oxide safe for bone marrow harvest? Anesthesia and analgesia, 1995, Volume: 80, Issue:4 Topics: Adult; Anesthesia; Bone Marrow; Bone Marrow Transplantation; Cell Survival; Colony-Forming Units Ass	1995
Premedication with oral and transdermal clonidine provides safe and efficacious postoperative sympatholysis. Anesthesia and analgesia, 1994, Volume: 79, Issue:6 Topics: Administration, Cutaneous; Administration, Oral; Aged; Anesthesia; Clonidine; Coronary Disease; Doub	1994
Laryngeal mask airway cuff pressure and position: the effect of adding nitrous oxide to the cuff. Anesthesiology, 1994, Volume: 80, Issue:4 Topics: Adolescent; Adult; Aged; Anesthesia; Dose-Response Relationship, Drug; Humans; Laryngeal Masks; Male	1994
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Absence of nonshivering thermogenesis in anesthetized adult humans. Anesthesiology, 1993, Volume: 79, Issue:4 Topics: Adult; Anesthesia; Body Temperature; Body Temperature Regulation; Female; Heating; Humans; Hypotherm	1993
Comparison of cardiovascular changes during anaesthesia and recovery from propofol-alfentanil-nitrous oxide and thiopentone-halothane-nitrous oxide anaesthesia in children undergoing otolaryngological surgery. Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:8 Topics: Alfentanil; Anesthesia; Blood Pressure; Child; Child, Preschool; Double-Blind Method; Electrocardiog	1993
Early and late recovery after major abdominal surgery. Comparison between propofol anaesthesia with and without nitrous oxide and isoflurane anaesthesia. Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:8 Topics: Abdomen; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia Recovery Period; Female; Humans; Iso	1993
Propofol infusion and the incidence of emesis in pediatric outpatient strabismus surgery. Anesthesia and analgesia, 1993, Volume: 76, Issue:4 Topics: Anesthesia; Child; Child, Preschool; Double-Blind Method; Female; Halothane; Humans; Infusions, Intr	1993
Continuous intravenous infusion of rocuronium (ORG 9426) in patients receiving balanced, enflurane, or isoflurane anesthesia. Anesthesiology, 1993, Volume: 78, Issue:4 Topics: Adult; Aged; Androstanols; Anesthesia; Barbiturates; Drug Synergism; Enflurane; Female; Humans; Infu	1993
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Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children. Comparison of four anesthetic techniques using nitrous oxide with halothane or propofol. Anesthesiology, 1996, Volume: 85, Issue:1 Topics: Adenoidectomy; Anesthesia; Child; Child, Preschool; Female; Halothane; Humans; Male; Nitrous Oxide;	1996
Airway sealing pressures of the laryngeal mask airway in pediatric patients. Journal of clinical anesthesia, 1996, Volume: 8, Issue:2 Topics: Adolescent; Air Pressure; Anesthesia; Anesthesiology; Child; Child, Preschool; Elasticity; Halothane	1996
Dose-response relationships for edrophonium antagonism of mivacurium-induced neuromuscular block during N2O-enflurane-alfentanil anaesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:10 Topics: Adolescent; Adult; Aged; Alfentanil; Anesthesia; Cholinesterase Inhibitors; Dose-Response Relationsh	1995
[Awakening from anesthesia and recovery of cognitive function after desflurane or isoflurane]. Der Anaesthesist, 1996, Volume: 45, Issue:2 Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Cognition; Desflurane; Femal	1996
Cisatracurium during halothane and balanced anaesthesia in children. Paediatric anaesthesia, 1996, Volume: 6, Issue:5 Topics: Anesthesia; Anesthesia, Inhalation; Anesthetics, Combined; Anesthetics, Inhalation; Atracurium; Bloo	1996
Haemodynamic effects of high-dose vecuronium compared with pancuronium in beta-blocked patients with coronary artery disease during fentanyl-diazepam-nitrous oxide anaesthesia. Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Anesthesia; Coronary Disease; Diazepam; Female; Fentanyl; Hemodyn	1996
The influence of the duration of isoflurane anaesthesia on neuromuscular effects of mivacurium. Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:2 Topics: Anesthesia; Anesthetics, Inhalation; Child; Child, Preschool; Electromyography; Humans; Infant; Isof	1997
Recovery and outcome after propofol and isoflurane anesthesia in patients undergoing laparoscopic hysterectomy. Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:3 Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anesthetics, Intravenous; Female; Humans; Hysterectom	1997
Bispectral index monitoring allows faster emergence and improved recovery from propofol, alfentanil, and nitrous oxide anesthesia. BIS Utility Study Group. Anesthesiology, 1997, Volume: 87, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alfentanil; Anesthesia; Anesthetics, Intravenous; Electr	1997
The effect of nitrous oxide diffusion on laryngeal mask airway cuff inflation in children. Paediatric anaesthesia, 1998, Volume: 8, Issue:1 Topics: Anesthesia; Anesthetics, Inhalation; Child; Child, Preschool; Diffusion; Humans; In Vitro Techniques	1998
Effects of xenon on hemodynamic responses to skin incision in humans. Anesthesiology, 1999, Volume: 90, Issue:2 Topics: Adult; Anesthesia; Anesthetics, Inhalation; Dermatologic Surgical Procedures; Female; Hemodynamics;	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients. Anesthesia and analgesia, 1999, Volume: 89, Issue:1 Topics: Adult; Aged; Anesthesia; Anesthetics, Inhalation; Female; Humans; Intubation, Intratracheal; Male; M	1999
Droperidol-supplemented anaesthesia decreases post-operative nausea and vomiting but impairs post-operative mood and well-being. European journal of anaesthesiology, 1999, Volume: 16, Issue:5 Topics: Adjuvants, Anesthesia; Adult; Affect; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous;	1999
Jugular bulb oxygen saturation during propofol and isoflurane/nitrous oxide anesthesia in patients undergoing brain tumor surgery. Anesthesia and analgesia, 1999, Volume: 89, Issue:2 Topics: Adult; Anesthesia; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood F	1999
Fentanyl pretreatment does not impair the reliability of an epinephrine-containing test dose during propofol-nitrous oxide anesthesia. Anesthesia and analgesia, 1999, Volume: 89, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Anestheti	1999
The potency (ED50) and cardiovascular effects of rapacuronium (Org 9487) during narcotic-nitrous oxide-propofol anesthesia in neonates, infants, and children. Anesthesia and analgesia, 1999, Volume: 89, Issue:5 Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Child; Child, Prescho	1999
The influence of the type of anaesthesia on postoperative pain after kidney transplantation. Annals of transplantation, 2000, Volume: 5, Issue:1 Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Anesthesia; Fentanyl; Halothane; Humans; Iso	2000
Endotracheal intubation with thiopental/succinylcholine or sevoflurane-nitrous oxide anesthesia in adults: a comparative study. Anesthesia and analgesia, 2001, Volume: 92, Issue:2 Topics: Adult; Anesthesia; Double-Blind Method; Female; Humans; Intubation, Intratracheal; Male; Methyl Ethe	2001
Remifentanil- and fentanyl-based anesthesia for intraoperative monitoring of somatosensory evoked potentials. Anesthesia and analgesia, 2001, Volume: 92, Issue:6 Topics: Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Evoked Potentials, Somatosensory; Fe	2001
The rotational technique with a partially inflated laryngeal mask airway improves the ease of insertion in children. Paediatric anaesthesia, 2002, Volume: 12, Issue:5 Topics: Anesthesia; Anesthetics, Inhalation; Child; Child, Preschool; Humans; Infant; Intraoperative Complic	2002
Awareness during surgery--a new approach. British journal of anaesthesia, 1979, Volume: 51, Issue:11 Topics: Adult; Amnesia; Anesthesia; Anti-Anxiety Agents; Consciousness; Dose-Response Relationship, Drug; Fe	1979
The effectiveness and safety of electroconvulsive therapy (ECT). The Journal of nervous and mental disease, 1977, Volume: 164, Issue:6 Topics: Acute Disease; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Chronic Disease; Clinica	1977
The effect of suxamethonium alone and its interaction with gallamine on the indirectly elicited tetanic and single twitch contractions of skeletal muscle in man during anaesthesia. British journal of clinical pharmacology, 1975, Volume: 2, Issue:5 Topics: Adolescent; Adult; Aged; Anesthesia; Clinical Trials as Topic; Depression, Chemical; Drug Interactio	1975
Cerebral responses to the addition of nitrous oxide to halothane in man. British journal of anaesthesia, 1976, Volume: 48, Issue:10 Topics: Anesthesia; Cerebrovascular Circulation; Clinical Trials as Topic; Electroencephalography; Female; H	1976
Studies on dimethyl tubocurarine in anaesthetized man. British journal of anaesthesia, 1976, Volume: 48, Issue:10 Topics: Anesthesia; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Heart Rate;	1976
Comparative effects of laryngeal mask airway and endotracheal tube insertion on intraocular pressure in children. Anesthesia and analgesia, 1992, Volume: 75, Issue:3 Topics: Anesthesia; Child; Child, Preschool; Epiglottis; Female; Halothane; Hemodynamics; Humans; Infant; In	1992
Use of midazolam ('Dormicum') and flumazenil ('Anexate') in paediatric bronchology. Current medical research and opinion, 1992, Volume: 12, Issue:9 Topics: Anesthesia; Atropine; Bronchoscopy; Child, Preschool; Chronic Disease; Drug Administration Schedule;	1992
Oral transmucosal fentanyl citrate for preanesthetic medication of pediatric day surgery patients with and without droperidol as a prophylactic anti-emetic. Anesthesiology, 1992, Volume: 76, Issue:1 Topics: Administration, Oral; Ambulatory Surgical Procedures; Anesthesia; Anesthesia Recovery Period; Child;	1992
An evaluation of combining thiopentone and etomidate for the induction of anaesthesia. Postgraduate medical journal, 1990, Volume: 66, Issue:777 Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Bloo	1990
[Balanced anesthesia without N2O. Its use in thoracic surgery]. Minerva anestesiologica, 1990, Volume: 56, Issue:9 Topics: Adult; Anesthesia; Female; Humans; Isoflurane; Lung; Male; Nitrous Oxide	1990
A comparison of alfentanil, halothane and enflurane as supplements for outpatient urological surgery. Anaesthesia and intensive care, 1989, Volume: 17, Issue:3 Topics: Alfentanil; Ambulatory Care; Anesthesia; Anesthesia Recovery Period; Anesthetics; Cystoscopy; Enflur	1989
Mivacurium-induced neuromuscular blockade following single bolus doses and with continuous infusion during either balanced or enflurane anesthesia. Anesthesiology, 1989, Volume: 71, Issue:3 Topics: Adult; Anesthesia; Anesthesia Recovery Period; Dose-Response Relationship, Drug; Drug Evaluation; En	1989
[Anesthesia in patients with varicose syndrome]. Acta chirurgica Iugoslavica, 1989, Volume: 36 Suppl 1 Topics: Anesthesia; Halothane; Humans; Ketamine; Nitrous Oxide; Pain, Postoperative; Varicose Veins	1989
Randomized comparison of outcome after propofol-nitrous oxide or enflurane-nitrous oxide anaesthesia in operations of long duration. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1989, Volume: 36, Issue:6 Topics: Adult; Anesthesia; Blood Pressure; Enflurane; Female; Humans; Male; Middle Aged; Nitrous Oxide; Prop	1989
Dose-response curves for suxamethonium in neonates, infants and children. British journal of anaesthesia, 1989, Volume: 62, Issue:6 Topics: Anesthesia; Child; Child, Preschool; Dose-Response Relationship, Drug; Fentanyl; Humans; Infant; Inf	1989
Methotrexate/nitrous-oxide toxic interaction in perioperative chemotherapy for early breast cancer. Lancet (London, England), 1987, Jul-18, Volume: 2, Issue:8551 Topics: Aged; Anesthesia; Breast Neoplasms; Drug Interactions; Humans; Mastectomy; Methotrexate; Nitrous Oxi	1987
[Hemodynamics under propofol-nitrous oxide anesthesia: effects of premedication with lormetazepam and of additional fentanyl]. Der Anaesthesist, 1987, Volume: 36, Issue:11 Topics: Anesthesia; Anesthetics; Anti-Anxiety Agents; Benzodiazepines; Blood Pressure; Cardiac Output; Fenta	1987
The efficacy of flumazenil versus physostigmine after midazolam-alfentanil anaesthesia in man. European journal of anaesthesiology. Supplement, 1988, Volume: 2 Topics: Adult; Alfentanil; Anesthesia; Anesthesia Recovery Period; Double-Blind Method; Female; Fentanyl; Fl	1988
Comparison of three anesthetic techniques on emetic symptoms using sufentanil for outpatient surgery. AANA journal, 1987, Volume: 55, Issue:3 Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthesia; Anesthesia, Inhalation; Anesthesia, I	1987
[Lung compliance in man is impaired by the rapid injection of alfentanyl]. Der Anaesthesist, 1986, Volume: 35, Issue:9 Topics: Adult; Alfentanil; Anesthesia; Anesthetics; Female; Fentanyl; Humans; Lung Compliance; Male; Middle	1986
The minimum alveolar concentration (MAC) of sevoflurane in humans. Anesthesiology, 1987, Volume: 66, Issue:3 Topics: Adult; Anesthesia; Anesthetics; Ethers; Female; Humans; Male; Methyl Ethers; Middle Aged; Nitrous Ox	1987
Liver function in patients with mild alcoholic hepatitis, after enflurane, nitrous oxide-narcotic, and spinal anesthesia. Anesthesia and analgesia, 1985, Volume: 64, Issue:5 Topics: Adult; Alanine Transaminase; Anesthesia; Anesthesia, General; Anesthesia, Spinal; Aspartate Aminotra	1985
A new steroid muscle relaxant. Dacuronium-NB.68 (Organon). Anaesthesia, 1970, Volume: 25, Issue:3 Topics: Androstanes; Anesthesia; Atropine; Clinical Trials as Topic; Gallamine Triethiodide; Halothane; Huma	1970
Some effects of the peritoneal insufflation of carbon dioxide at laparoscopy. Anaesthesia, 1970, Volume: 25, Issue:3 Topics: Adolescent; Adult; Amenorrhea; Anesthesia; Arteries; Blood; Carbon Dioxide; Electrocardiography; Fem	1970
The cardiovascular effects of pancuronium bromide. Anaesthesia, 1970, Volume: 25, Issue:3 Topics: Analgesics; Androstanes; Anesthesia; Bis-Trimethylammonium Compounds; Blood Pressure; Bromides; Hear	1970
The interaction of pentazocine and pethidine in anaesthetized man. Anaesthesia and intensive care, 1973, Volume: 1, Issue:3 Topics: Adult; Anesthesia; Blood Pressure; Depression, Chemical; Drug Interactions; Humans; Meperidine; Nitr	1973
A quantitative evaluation of psycho-prophylaxis in childbirth. Journal of psychosomatic research, 1972, Volume: 16, Issue:2 Topics: Adult; Anesthesia; Apgar Score; Evaluation Studies as Topic; Female; Humans; Labor, Induced; Labor,	1972
Innovar in surgical anaesthesia. Canadian Anaesthetists' Society journal, 1965, Volume: 12, Issue:6 Topics: Adult; Anesthesia; Benperidol; Clinical Trials as Topic; Female; Fentanyl; Humans; Intubation, Intra	1965
Para-anaesthetic headache in female patients. Anaesthesia, 1970, Volume: 25, Issue:3 Topics: Anesthesia; Antiemetics; Barbiturates; Female; Headache; Humans; Methohexital; Migraine Disorders; M	1970
[Minimal anesthetic concentration of halothane for the determination of the effect of premedication]. Der Anaesthesist, 1968, Volume: 17, Issue:2 Topics: Abdomen; Absorption; Adult; Anesthesia; Atropine; Female; Genital Diseases, Female; Halothane; Human	1968

nitrous oxide and Anesthesia