Page last updated: 2024-10-19

nitrous oxide and Acute Post-Traumatic Stress Disorder

nitrous oxide has been researched along with Acute Post-Traumatic Stress Disorder in 5 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Research Excerpts

ExcerptRelevanceReference
" We examined whether the N-methyl d-aspartate receptor (NMDAR) antagonist gas nitrous oxide (N2O) could reduce the frequency of intrusive memories by inhibiting NMDAR-dependent memory consolidation in a laboratory analogue of psychological trauma."9.22Nitrous oxide speeds the reduction of distressing intrusive memories in an experimental model of psychological trauma. ( Bisby, JA; Das, RK; Freeman, TP; Kamboj, SK; Lazzarino, AI; Nikolova, V; Tamman, A, 2016)
" We examined whether the N-methyl d-aspartate receptor (NMDAR) antagonist gas nitrous oxide (N2O) could reduce the frequency of intrusive memories by inhibiting NMDAR-dependent memory consolidation in a laboratory analogue of psychological trauma."5.22Nitrous oxide speeds the reduction of distressing intrusive memories in an experimental model of psychological trauma. ( Bisby, JA; Das, RK; Freeman, TP; Kamboj, SK; Lazzarino, AI; Nikolova, V; Tamman, A, 2016)
"Posttraumatic Stress Disorder (PTSD) is a debilitating mental health disorder."1.62The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development. ( Breines Simonsen, T; Deforges, C; Eberhard-Gran, M; Garthus-Niegel, S; Horsch, A; Noël, Y; Robertson, M; Stuijfzand, S, 2021)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's3 (60.00)2.80

Authors

AuthorsStudies
Liu, H1
Kerzner, J1
Demchenko, I1
Wijeysundera, DN1
Kennedy, SH1
Ladha, KS1
Bhat, V1
Varias, A1
van Roessel, P1
Parsiani, M1
Filippou-Frye, M1
Neylan, TC1
Nagele, P1
Yesavage, J1
Clark, JD1
Rodriguez, CI1
Deforges, C1
Stuijfzand, S1
Noël, Y1
Robertson, M1
Breines Simonsen, T1
Eberhard-Gran, M1
Garthus-Niegel, S1
Horsch, A1
Printz, C1
Das, RK1
Tamman, A1
Nikolova, V1
Freeman, TP1
Bisby, JA1
Lazzarino, AI1
Kamboj, SK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD)[NCT03375294]Phase 23 participants (Actual)Interventional2018-04-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Patients Who Met and Exceeded Response Criteria of Clinician Administered PTSD Scale for DSM-5 (CAPS-5)

Patients given CAPS-5 (Clinician Administered PTSD Scale for DSM-5), a 30-item structured interview that can be used to assess PTSD symptoms over the past week. For the CAPS-5 the minimum units are 0 and maximum units on the total scale are 80. The higher the number on the CAPS-5, the more severe the symptoms. Response was defined as at least a 12 point reduction on the CAPS-5 (NCT03375294)
Timeframe: Baseline and 1 week post inhalation

InterventionParticipants (Count of Participants)
Nitrous Oxide2

Reviews

1 review available for nitrous oxide and Acute Post-Traumatic Stress Disorder

ArticleYear
Nitrous oxide for the treatment of psychiatric disorders: A systematic review of the clinical trial landscape.
    Acta psychiatrica Scandinavica, 2022, Volume: 146, Issue:2

    Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Nitrous Oxide; Stress Disorders, Post-Traumati

2022

Trials

1 trial available for nitrous oxide and Acute Post-Traumatic Stress Disorder

ArticleYear
Nitrous oxide speeds the reduction of distressing intrusive memories in an experimental model of psychological trauma.
    Psychological medicine, 2016, Volume: 46, Issue:8

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Female; Heart Rate; Humans; Male; Memory; Memory Consol

2016

Other Studies

3 other studies available for nitrous oxide and Acute Post-Traumatic Stress Disorder

ArticleYear
Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series.
    The Journal of clinical psychiatry, 2020, 06-30, Volume: 81, Issue:4

    Topics: Adult; Anesthetics, Inhalation; Humans; Middle Aged; Nitrous Oxide; Stress Disorders, Post-Traumatic

2020
The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development.
    Journal of affective disorders, 2021, 02-15, Volume: 281

    Topics: Cohort Studies; Female; Humans; Morphine; Nitrous Oxide; Pregnancy; Prospective Studies; Stress Diso

2021
Indiana CTSI scientists target therapeutic for posttraumatic stress disorder.
    Clinical and translational science, 2015, Volume: 8, Issue:2

    Topics: Animals; Antidepressive Agents; Brain; Humans; Indiana; Nitrous Oxide; Rats; Stress Disorders, Post-

2015