Page last updated: 2024-10-19

nitrous oxide and Acute Pain

nitrous oxide has been researched along with Acute Pain in 12 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"Methoxyflurane is more effective than MEOPA in acute pain in burn dressing, improved patient comfort, and improved dressing quality."9.34[Use of methoxyflurane on acute pain during burn dressing in adult consultation]. ( Bertrand-Vasseur, A; Duteille, F; Leduc, A; Perrot, P; Verdier, J, 2020)
"A short-cut review of the literature was carried out to establish whether inhaled methoxyflurane (Penthrox) is comparable or superior with a standard inhalational analgesia for the management of acute pain."9.01BET 1: Green or blue for you? Methoxyflurane (Penthrox) or nitrous oxide/oxygen 50% mixture (Entonox) for the management of acute pain in the ED. ( Quinn, E; Rahman, SM, 2019)
"Methoxyflurane is more effective than MEOPA in acute pain in burn dressing, improved patient comfort, and improved dressing quality."5.34[Use of methoxyflurane on acute pain during burn dressing in adult consultation]. ( Bertrand-Vasseur, A; Duteille, F; Leduc, A; Perrot, P; Verdier, J, 2020)
"Acute pain is the most common complaint in Emergency Department (ED) admissions, and options for analgesia are limited."2.90Analgesic Effect of Nitrous Oxide/Oxygen Mixture for Traumatic Pain in the Emergency Department: A Randomized, Double-Blind Study. ( Dai, YL; Gao, HX; Gao, LL; Li, YX; Liu, Q; Wang, YL; Yang, JJ; Yu, JQ; Zhang, JJ; Zhang, TT, 2019)
"Acute pain is always the most common complaint in Emergency Department admissions and options for analgesia are limited."2.87A fixed nitrous oxide/oxygen mixture as an analgesic for trauma patients in emergency department: study protocol for a randomized, controlled trial. ( Bao, JT; Dai, YL; Feng, K; Gao, LL; Li, Q; Li, YX; Liu, Q; Ma, L; Wang, QH; Wang, YL; Yang, LS; Yu, QJ; Yu, YY; Zhang, JJ, 2018)
"Treatment of acute pain is a central task in emergency medicine."2.82[Volatile anesthetics for prehospital analgesia by paramedics-An overview]. ( Beywinkler, C; Doppler, R; Egger, A; Kreutziger, J; Trimmel, H; Voelckel, WG, 2022)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (75.00)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Trimmel, H1
Egger, A1
Doppler, R1
Beywinkler, C1
Voelckel, WG1
Kreutziger, J1
Wang, Z1
Wang, F1
Li, Y1
Xing, Y1
Jiang, X1
Li, C1
Ding, Z1
Tang, L1
Gao, LL2
Yu, JQ1
Liu, Q2
Gao, HX1
Dai, YL2
Zhang, JJ2
Wang, YL2
Zhang, TT1
Yang, JJ1
Li, YX2
Delafontaine, A1
Presedo, A1
Mohamed, D1
Lopes, D1
Wood, C1
Alberti, C1
Yang, LS1
Feng, K1
Ma, L1
Yu, YY1
Li, Q1
Wang, QH1
Bao, JT1
Yu, QJ1
Andolfatto, G1
Innes, K1
Dick, W1
Jenneson, S1
Willman, E1
Stenstrom, R1
Zed, PJ1
Benoit, G1
Verdier, J1
Leduc, A1
Duteille, F1
Bertrand-Vasseur, A1
Perrot, P1
Rahman, SM1
Quinn, E1
Ducassé, JL1
Siksik, G1
Durand-Béchu, M1
Couarraze, S1
Vallé, B1
Lecoules, N1
Marco, P1
Lacombe, T1
Bounes, V1
Faguer, S1
Ruiz, J1
Mari, A1
Young, A1
Ismail, M1
Papatsoris, AG1
Barua, JM1
Calleary, JG1
Masood, J1
Johnston, KD1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Evaluation of the Efficacy of MEOPA Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia."[NCT00632528]Phase 364 participants (Actual)Interventional2008-03-31Completed
Chronic Postsurgical Pain in Cerebral Palsy[NCT05764681]500 participants (Anticipated)Observational2023-03-31Not yet recruiting
Prehospital Analgesia With Intra-Nasal Ketamine[NCT02753114]Phase 4120 participants (Actual)Interventional2017-11-06Completed
Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post Traumatic Acute Pain in the Emergency Department[NCT05229055]Phase 2/Phase 31,000 participants (Anticipated)Interventional2023-04-15Recruiting
Efficacy of Premixed Nitrous Oxide and Oxygen in Patient With Out-of-hospital Moderate Acute Pain: a Randomized Double-blind Study[NCT01356745]Phase 460 participants (Actual)Interventional2010-02-28Completed
Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation[NCT05579288]Early Phase 160 participants (Anticipated)Interventional2022-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for nitrous oxide and Acute Pain

ArticleYear
[Volatile anesthetics for prehospital analgesia by paramedics-An overview].
    Der Anaesthesist, 2022, Volume: 71, Issue:3

    Topics: Acute Pain; Adult; Allied Health Personnel; Anesthetics; Child; Emergency Medical Services; Humans;

2022
BET 1: Green or blue for you? Methoxyflurane (Penthrox) or nitrous oxide/oxygen 50% mixture (Entonox) for the management of acute pain in the ED.
    Emergency medicine journal : EMJ, 2019, Volume: 36, Issue:8

    Topics: Acute Pain; Analgesics; Emergency Service, Hospital; Humans; Methoxyflurane; Nitrous Oxide; Oxygen;

2019
Entonox® inhalation to reduce pain in common diagnostic and therapeutic outpatient urological procedures: a review of the evidence.
    Annals of the Royal College of Surgeons of England, 2012, Volume: 94, Issue:1

    Topics: Acute Pain; Ambulatory Care; Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Inh

2012

Trials

7 trials available for nitrous oxide and Acute Pain

ArticleYear
Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial.
    Trials, 2023, Nov-27, Volume: 24, Issue:1

    Topics: Acute Pain; Adolescent; Analgesics; Anterior Cruciate Ligament Reconstruction; Humans; Musculoskelet

2023
Analgesic Effect of Nitrous Oxide/Oxygen Mixture for Traumatic Pain in the Emergency Department: A Randomized, Double-Blind Study.
    The Journal of emergency medicine, 2019, Volume: 57, Issue:4

    Topics: Acute Pain; Adult; Analgesics; Double-Blind Method; Drug Combinations; Emergency Service, Hospital;

2019
Equimolar mixture of nitroux oxyde and oxygen during post-operative physiotherapy in patients with cerebral palsy: A randomized, double-blind, placebo-controlled study.
    European journal of pain (London, England), 2017, Volume: 21, Issue:10

    Topics: Acute Pain; Adolescent; Analgesics, Non-Narcotic; Cerebral Palsy; Child; Double-Blind Method; Female

2017
Equimolar mixture of nitroux oxyde and oxygen during post-operative physiotherapy in patients with cerebral palsy: A randomized, double-blind, placebo-controlled study.
    European journal of pain (London, England), 2017, Volume: 21, Issue:10

    Topics: Acute Pain; Adolescent; Analgesics, Non-Narcotic; Cerebral Palsy; Child; Double-Blind Method; Female

2017
Equimolar mixture of nitroux oxyde and oxygen during post-operative physiotherapy in patients with cerebral palsy: A randomized, double-blind, placebo-controlled study.
    European journal of pain (London, England), 2017, Volume: 21, Issue:10

    Topics: Acute Pain; Adolescent; Analgesics, Non-Narcotic; Cerebral Palsy; Child; Double-Blind Method; Female

2017
Equimolar mixture of nitroux oxyde and oxygen during post-operative physiotherapy in patients with cerebral palsy: A randomized, double-blind, placebo-controlled study.
    European journal of pain (London, England), 2017, Volume: 21, Issue:10

    Topics: Acute Pain; Adolescent; Analgesics, Non-Narcotic; Cerebral Palsy; Child; Double-Blind Method; Female

2017
A fixed nitrous oxide/oxygen mixture as an analgesic for trauma patients in emergency department: study protocol for a randomized, controlled trial.
    Trials, 2018, Sep-29, Volume: 19, Issue:1

    Topics: Acute Pain; Administration, Inhalation; Analgesics, Non-Narcotic; China; Double-Blind Method; Emerge

2018
Prehospital Analgesia With Intranasal Ketamine (PAIN-K): A Randomized Double-Blind Trial in Adults.
    Annals of emergency medicine, 2019, Volume: 74, Issue:2

    Topics: Acute Pain; Administration, Intranasal; Adult; Aged; Analgesics; Anesthetics, Inhalation; Double-Bli

2019
Prehospital Analgesia With Intranasal Ketamine (PAIN-K): A Randomized Double-Blind Trial in Adults.
    Annals of emergency medicine, 2019, Volume: 74, Issue:2

    Topics: Acute Pain; Administration, Intranasal; Adult; Aged; Analgesics; Anesthetics, Inhalation; Double-Bli

2019
Prehospital Analgesia With Intranasal Ketamine (PAIN-K): A Randomized Double-Blind Trial in Adults.
    Annals of emergency medicine, 2019, Volume: 74, Issue:2

    Topics: Acute Pain; Administration, Intranasal; Adult; Aged; Analgesics; Anesthetics, Inhalation; Double-Bli

2019
Prehospital Analgesia With Intranasal Ketamine (PAIN-K): A Randomized Double-Blind Trial in Adults.
    Annals of emergency medicine, 2019, Volume: 74, Issue:2

    Topics: Acute Pain; Administration, Intranasal; Adult; Aged; Analgesics; Anesthetics, Inhalation; Double-Bli

2019
[Use of methoxyflurane on acute pain during burn dressing in adult consultation].
    Annales de chirurgie plastique et esthetique, 2020, Volume: 65, Issue:2

    Topics: Acute Pain; Adult; Anesthetics, Inhalation; Bandages; Burns; Female; Humans; Male; Methoxyflurane; N

2020
Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2013, Volume: 20, Issue:2

    Topics: Acute Pain; Adult; Aged; Analgesia; Double-Blind Method; Emergency Service, Hospital; Female; Humans

2013
Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2013, Volume: 20, Issue:2

    Topics: Acute Pain; Adult; Aged; Analgesia; Double-Blind Method; Emergency Service, Hospital; Female; Humans

2013
Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2013, Volume: 20, Issue:2

    Topics: Acute Pain; Adult; Aged; Analgesia; Double-Blind Method; Emergency Service, Hospital; Female; Humans

2013
Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2013, Volume: 20, Issue:2

    Topics: Acute Pain; Adult; Aged; Analgesia; Double-Blind Method; Emergency Service, Hospital; Female; Humans

2013

Other Studies

2 other studies available for nitrous oxide and Acute Pain

ArticleYear
Massive hyperhomocysteinaemia as a complication of nitrous oxide inhalation.
    British journal of clinical pharmacology, 2016, Volume: 81, Issue:2

    Topics: Acute Pain; Administration, Inhalation; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Female

2016
Entonox® inhalation to reduce pain in common diagnostic and therapeutic outpatient urological procedures: a review of the evidence.
    Annals of the Royal College of Surgeons of England, 2012, Volume: 94, Issue:4

    Topics: Acute Pain; Anesthetics, Combined; Anesthetics, Inhalation; Female; Humans; Male; Nitrous Oxide; Oxy

2012