nitrous oxide has been researched along with Ache in 334 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pain intensity was comparable in multiparous patients 20-30 minutes after administration of meperidine and nitrous oxide." | 9.69 | Meperidine Compared With Nitrous Oxide for Intrapartum Pain Relief in Multiparous Patients: A Randomized Controlled Trial. ( Dagilayske, D; Garmi, G; Inbar, S; Salim, R; Zafran, N; Zuarez-Easton, S, 2023) |
| "The nitrous oxide system provides clinically significant pain reduction, increases patient satisfaction, and improves cosmetic results of MFU-V treatment." | 9.51 | Prospective, Single-arm, Split-face Pain Management Evaluation of Nitrous Oxide System During Micro-Focused Ultrasound With Visualization. ( Dong, K; Lultschik, S; Sapra, S; Tran, J, 2022) |
| "This study aims to evaluate the safety and analgesic efficacy of pre-mixed nitrous oxide/oxygen mixture treatment of pain induced by dressing change for perianal abscess." | 9.34 | Pre-mixed nitrous oxide/oxygen mixture treatment of pain induced by postoperative dressing change for perianal abscess: Study protocol for a randomized, controlled trial. ( Bao, WQ; Dai, YL; Gao, HX; Gao, LL; Ge, ZM; Li, YX; Li, ZJ; Liu, Q; Meng, K; Mou, JY; Yang, Y; Yu, JQ; Zhang, JJ; Zhang, TT, 2020) |
| "This prospective, double-blind, placebo-controlled study was designed to determine the efficacy of nitrous oxide (N(2)O) in alleviating the pain that followed sequential injection of propofol and rocuronium." | 9.17 | Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection. ( Kim, CH; Kim, E; Kim, HK; Kim, HY; Kwon, JY; Lee, DW, 2013) |
| " Due to the severity of the pain suffered, ethically it was decided to help as many as possible, so patients given the letters A, B or C were treated using a canister with the appropriate letter containing preprepared nitrous oxide/oxygen mixture (NOOM)." | 9.16 | Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain: study protocol for a randomized controlled trial. ( Guangyi, W; Guoxia, M; Hongtai, T; Jianqiang, Y; Jijun, Z; Lu, T; Ming, Y; Shichu, X; Wanfang, Z; Wannian, Z; Wen, N; Wenjun, H; Xiaoyan, H; Xiuqiang, M; Xiuying, D; Yinsheng, W; Yuxiang, L; Zhaofan, X, 2012) |
| "To determine technical and clinical factors associated with pain when using an analgesic protocol with 50% nitrous oxide/oxygen and anesthetic cream (lidocaine and prilocaine, Emla(®)) for children with cerebral palsy undergoing botulinum toxin injections." | 9.15 | Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream. ( Blajan, V; Brochard, S; Garlantezec, R; Houx, L; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2011) |
| "This randomized, single-dose, double-blind, Phase III study was designed to compare the level of procedural pain after use of premixed equimolar mixture of 50% oxygen and nitrous oxide (EMONO) or placebo (premixed 50% nitrogen and oxygen)." | 9.15 | Equimolar nitrous oxide/oxygen versus placebo for procedural pain in children: a randomized trial. ( Billoët, C; de Lucas, R; Dequenne, V; García, S; Onody, P; Pascual-Pascual, SI; Reinoso-Barbero, F, 2011) |
| "To compare the effectiveness of nitrous oxide/oxygen (N(2)O/O(2)) and fentanyl in relieving pain among patients with an isolated long bone fracture or main joint dislocation of the limbs." | 9.15 | Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: a randomized trial. ( Amini, A; Derakhshanfar, H; Dolatabadi, AA; Hatamabadi, H; Kariman, H; Majidi, A; Shahrami, A; Sheibani, K; Yaseri, M, 2011) |
| "To investigate the time of administration and concentration of inhaled nitrous oxide (N(2)O) needed to reduce the pain associated with intravenous (i." | 9.14 | The effective time and concentration of nitrous oxide to reduce venipuncture pain in children. ( Fukao, T; Furuya, A; Horimoto, Y; Ishiyama, T; Ito, M; Matsukawa, T; Nishi, M; Okuyama, K; Sato, H; Suwa, M, 2009) |
| "To compare intravenous titrated midazolam 5-10 mg and inhaled Entonox in addition to local anaesthesia in order to identify which agent provides optimum pain relief." | 9.13 | Midazolam in conjunction with local anaesthesia is superior to Entonox in providing pain relief during bone marrow aspirate and trephine biopsy. ( Allotey, D; Bratby, L; Chakupurakal, G; de la Rue, J; Delgado, J; Holder, K; Milligan, DW; Nikolousis, E; Pitchapillai, S, 2008) |
| " Mean +/- SD Modified Behavioral Pain Scale pain scores for EMLA, nitrous oxide/oxygen, and nitrous oxide/oxygen plus EMLA were, respectively, 9." | 9.13 | EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children. ( Annequin, D; Biran, V; Carbajal, R; Cimerman, P; Epaud, R; Fauroux, B; Gold, F; Lenclen, R; Thibault, P, 2008) |
| "To assess the efficacy of equimolar mixture of nitrous oxide/oxygen (EMNO) to prevent pain induced by venous access ports (VAPs) implantation in cancer patients." | 9.12 | Prospective, double-blind, randomized trial of equimolar mixture of nitrous oxide/oxygen to prevent pain induced by insertion of venous access ports in cancer patients. ( Bussières, L; Chevret, S; d'Agostino, P; di Palma, M; Douard, MC; Falissard, B; George, B; Kriegel, I; Misset, JL; Thierry, P, 2006) |
| "Inhaled nitrous oxide (N2O) is a potent sedative-analgesic-anxiolytic agent that may relieve anxiety and discomfort during CAF ablation." | 9.12 | A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation. ( Bertaux, G; Fraison, M; Fromentin, S; Gonzalez, S; Laurent, G; Martel, A; Pierre, FS; Wolf, JE, 2006) |
| "This prospective study assessed the role of a 50:50 mixture of nitrous oxide (N2O) and oxygen for pain relief during the termination of first trimester pregnancies by suction evacuation under conscious sedation." | 9.12 | A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination. ( Caves, N; Ho, PC; Kan, AS; Ng, EH; Wong, SY, 2006) |
| " This article summarises a survey of the use of nitrous oxide to minimise the psychological trauma and pain that was undertaken within the paediatric unit of a district general hospital (Williams et al 2004)." | 9.12 | Inhaled nitrous oxide during painful procedures: a satisfaction survey. ( Rayner, R; Richardson, K; Riley, A; Williams, V, 2006) |
| "Patients experiencing pain during daily dressing changes were given entonox plus either placebo or oral transmucosal fentanyl citrate (OTFC) for two consecutive dressing changes in a randomised double-blind placebo-controlled crossover trial." | 9.12 | Oral transmucosal fentanyl citrate versus placebo for painful dressing changes: a crossover trial. ( Barker, L; Larsen, D; MacIntyre, PA; Margetts, L, 2007) |
| "Nitrous oxide inhalation significantly reduces cystoscopy related pain without significant complications." | 9.12 | Nitrous oxide inhalation to improve patient acceptance and reduce procedure related pain of flexible cystoscopy for men younger than 55 years. ( Barua, JM; Calleary, JG; Masood, J; Van-Mallaerts, R, 2007) |
| " lidocaine and nitrous oxide (N2O) in oxygen (O2) inhalation pre-treatment was compared with either treatment alone in the prevention of pain on propofol injection." | 9.11 | A combination of lidocaine and nitrous oxide in oxygen is more effective in preventing pain on propofol injection than either treatment alone. ( Elsaigh, I; Galvin, E; Harmon, D; Leonard, I; Niazi, A; Wahid, Z, 2005) |
| "In a randomized, double-blind, prospective trial we compared the efficacy of pre-treatment with nitrous oxide (with or without premixed lignocaine in propofol) for the prevention of propofol-induced pain." | 9.11 | Effect of nitrous oxide in reducing pain of propofol injection in adult patients. ( Neema, PK; Rathod, RC; Sinha, PK, 2005) |
| "To investigate if 50% nitrous oxide reduces the pain during injection of propofol mixed with lidocaine in children." | 9.10 | In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine. ( Beh, T; Kim, J; Splinter, W, 2002) |
| "Inhalation of nitrous oxide or adminstration of remifentanil attenuated pain-induced changes in CBFV(MCA)." | 9.10 | Remifentanil and nitrous oxide reduce changes in cerebral blood flow velocity in the middle cerebral artery caused by pain. ( Bauer, P; Benzer, A; Hinteregger, M; Kolbitsch, C; Lorenz, IH; Luger, TJ; Pfeiffer, KP; Schmidauer, C; Spiegel, M; Streif, W, 2003) |
| " Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0." | 9.10 | Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. ( Harmon, D; Lowe, D; Rozario, C, 2003) |
| "The authors conducted this study to compare the pain on injection of the three mandibular block techniques and to determine the effect that the delivery of nitrous oxide:oxygen, or N2O:O2, had on this pain." | 9.10 | Injection pain: comparison of three mandibular block techniques and modulation by nitrous oxide:oxygen. ( Haas, DA; Jacobs, S; May, S; Meechan, JG, 2003) |
| "To compare the effects of nitrous oxide with lidocaine on pain on injection caused by propofol in children." | 9.10 | [Prevention of pain on injection with propofol in children: comparison of nitrous oxide with lidocaine]. ( Ecoffey, C; Geslot, D; Lembert, N; Wodey, E, 2002) |
| "kg-1 propofolis not effective in the treatment of postoperative vomiting in children after adenotonsillectomy when a standardized anaesthetic with thiopentone, halothane, nitrous oxide, and 1." | 9.08 | Subhypnotic propofol does not treat postoperative vomiting in children after adenotonsillectomy. ( Carr, AS; Lerman, J; McAuliffe, G; Sikich, N; Smith, HS; Zestos, MM, 1997) |
| "To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group." | 9.08 | [Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998) |
| "We have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique." | 9.08 | Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain. ( Arendt-Nielsen, L; Curatolo, M; Luginbühl, M; Petersen-Felix, S; Schnider, TW; Zbinden, AM, 1998) |
| "To compare carbon dioxide and nitrous oxide pneumoperitoneum with respect to intraoperative and postoperative pain during laparoscopic sterilization under local anesthesia." | 9.07 | The effect of nitrous oxide and carbon dioxide pneumoperitoneum on operative and postoperative pain during laparoscopic sterilization under local anesthesia. ( Ling, FW; Lipscomb, GH; McCord, ML; Summitt, RL, 1994) |
| "Nitrous oxide in a concentration of 35% has been shown to ameliorate the pain of acute myocardial infarction." | 9.04 | Nitrous oxide as an analgesic in acute myocardial infarction. ( Lown, B; Thompson, PL, 1976) |
| " We wanted to study whether nitrous oxide/oxygen (NOO, Livopan(®), Linde Gas Therapeutics, Unterschleißheim, Germany) can reduce ISP in patients receiving intracutaneous BT injections for axillary or palmar hyperhidrosis (HH)." | 7.81 | Botulinum toxin therapy for hyperhidrosis: reduction of injection site pain by nitrous oxide/oxygen mixtures. ( Dengler, R; Dressler, D; Kollewe, K; Paracka, L, 2015) |
| "The Livopan study is a prospective, single-centre, explorative, controlled, observational study to investigate the pain reduction in patients after applying a nitrous oxide/oxygen mixture (Livopan) during PDT according to the visual analogue scale in 60 patients." | 7.81 | Pain reduction in patients after applying a nitrous oxide/oxygen mixture (Livopan) during photodynamic therapy: study protocol for an observational study (Livopan study). ( Enk, A; Fink, C; Gholam, P; Uhlmann, L, 2015) |
| "Using the rat chronic constriction injury (CCI) pain model, we evaluated whether nitrous oxide (N2O), a gas shown to have potent anti-hyperalgesic properties, may alleviate neuropathic pain." | 7.76 | A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. ( Bessière, B; Chateauraynaud, J; Laboureyras, E; Laulin, JP; Simonnet, G, 2010) |
| "Nitrous oxide gas, mixed 50:50 with oxygen, is an effective and safe analgesic which, although widely used in many areas of clinical practice, has not been fully recognized in the community setting for painful procedures." | 7.72 | Use of Entonox in the community for control of procedural pain. ( Evans, A, 2003) |
| "Although the equimolecular mixture of oxygen and nitrous oxide (EMONO) seems a good choice to relieve procedure-related pain in children, it has not been accepted everywhere." | 7.70 | Fixed 50% nitrous oxide oxygen mixture for painful procedures: A French survey. ( Annequin, D; Carbajal, R; Chauvin, P; Gall, O; Murat, I; Tourniaire, B, 2000) |
| "Combinations of transcutaneous electrical stimulation (TES) and inhalation of nitrous oxide with oxygen have been used for surgical pain control and this report explored the possible synergism of these two treatments." | 7.66 | Effects of nitrous oxide, transcutaneous electrical stimulation, and their combination on brain potentials elicited by painful stimulation. ( Chapman, CR; Colpitts, YH; Gehrig, JD; Gerlach, R; Schimek, F, 1983) |
| "Effects of inhaling three levels of nitrous oxide in oxygen on event-related brain potentials (ERPs) and pain report were examined in 10 volunteers undergoing painful electrical stimulation of tooth pulp." | 7.66 | Effect of nitrous oxide concentration on event-related potentials during painful tooth stimulation. ( Benedetti, C; Chapman, CR; Chen, AC; Colpitts, YH, 1982) |
| "The effects of 50% nitrous oxide and 50% oxygen and of 30% nitrous oxide and 70% oxygen were evaluated in 88 patients with significant pain while in the prehospital setting." | 7.66 | Prehospital administration of nitrous oxide for control of pain. ( Amey, BD; Ballinger, JA; Harrison, EE, 1981) |
| "The continuous administration of nitrous oxide, in subjects who remain conscious, caused only a relatively small increase in the threshold of appreciation of pain, induced experimentally by tibial pressure and a hot wire applied to the thenar eminence." | 7.65 | Pain during continuous nitrous oxide administration. ( Hall, GM; Morgan, M; Petrie, A; Whitwam, JG, 1976) |
| "Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0." | 7.11 | Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022) |
| "morphine during painful bedsore and ulcer care in adult and elderly patients, we conducted a randomized, crossover, multicenter, prospective, open-label, pilot study." | 6.73 | Nitrous oxide-oxygen mixture during care of bedsores and painful ulcers in the elderly: a randomized, crossover, open-label pilot study. ( Basset, P; Bosson, JL; Couturier, P; Franco, A; Horvath, R; Paris, A; Thiery, S, 2008) |
| "Nitrous oxide was beneficial during incidents in five of seven patients; the remaining two patients reported an overall preference for the nitrous oxide day." | 6.71 | Self-administered nitrous oxide for the management of incident pain in terminally ill patients: a blinded case series. ( Dudgeon, DJ; Griffiths, JM; Milne, B; Parlow, JL; Stewart, GI; Tod, DA, 2005) |
| "Six patients with uncontrolled cancer-related pain were studied." | 6.68 | Patient-controlled analgesia with nitrous oxide in cancer pain. ( Keating, HJ; Kundrat, M, 1996) |
| "Frequent blisters appear spontaneously, and are often preceded by erythema and itching." | 5.72 | Procedural analgesia with nitrous oxide at home for epidermolysis bullosa: A case report. ( Annicchiarico, G; Attolini, E; Dipietro, G; Laterza, C; Murciano, M; Rubino, A; Storelli, S, 2022) |
| "Pain intensity was comparable in multiparous patients 20-30 minutes after administration of meperidine and nitrous oxide." | 5.69 | Meperidine Compared With Nitrous Oxide for Intrapartum Pain Relief in Multiparous Patients: A Randomized Controlled Trial. ( Dagilayske, D; Garmi, G; Inbar, S; Salim, R; Zafran, N; Zuarez-Easton, S, 2023) |
| "Nitrous oxide may increase the success of the IANB." | 5.62 | Nitrous Oxide/Oxygen Effect on IANB Injection Pain and Mandibular Pulpal Anesthesia in Asymptomatic Subjects. ( Dds, MB; Drum, M; Fowler, S; Kushnir, B; Nusstein, J; Reader, A, 2021) |
| "The nitrous oxide system provides clinically significant pain reduction, increases patient satisfaction, and improves cosmetic results of MFU-V treatment." | 5.51 | Prospective, Single-arm, Split-face Pain Management Evaluation of Nitrous Oxide System During Micro-Focused Ultrasound With Visualization. ( Dong, K; Lultschik, S; Sapra, S; Tran, J, 2022) |
| "Nitrous oxide (N2O) with rapid analgesic effect is often used to relieve pain induced by diagnostic procedures." | 5.41 | Efficacy of nitrous oxide in adults undergoing puncture biopsy: A systematic review and meta-analysis of randomized controlled trials. ( Ding, Z; Jiang, X; Li, Y; Tang, L; Wang, F; Wang, Z; Xing, Y, 2023) |
| "Our study sought to determine whether or not nitrous oxide analgesia decreases pain compared to oxygen placebo during external cephalic version for breech presentation." | 5.41 | Nitrous oxide analgesia for external cephalic version: A randomized controlled trial. ( Chen, F; Fardelmann, KL; Harker, E; Li, Q; Penwarden, AA; Redmon, BF; Smith, KA; Straube, LE; Strauss, R, 2021) |
| "Nitrous oxide was effective in inducing anesthesia in neonatal piglets during handling." | 5.37 | Nitrous oxide by itself is insufficient to relieve pain due to castration in piglets. ( Lay, DC; Rault, JL, 2011) |
| "Nitrous oxide (N(2)O) is an attractive agent for procedural analgesia and sedation of children in the emergency department (ED)." | 5.35 | Limited analgesic efficacy of nitrous oxide for painful procedures in children. ( Babl, FE; Oakley, E; Puspitadewi, A; Sharwood, LN, 2008) |
| "Nitrous oxide is an effective analgesic when performing bone-marrow biopsies." | 5.35 | [Pain prevention with fixed 50% nitrous oxide-oxygen mixture during bone-marrow biopsy]. ( Bernit, E; Gayet, S; Harlé, JR; Kaplanski, G; Mazodier, K; Sati, H; Schleinitz, N; Veit, V, 2009) |
| "Pain was evaluated with the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS), the Visual Analogue Scale (VAS) and the Face Pain Scale (FPS) for the children and with a VAS for the parents." | 5.35 | Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children. ( Blajan, V; Brochard, S; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2009) |
| "This study aims to evaluate the safety and analgesic efficacy of pre-mixed nitrous oxide/oxygen mixture treatment of pain induced by dressing change for perianal abscess." | 5.34 | Pre-mixed nitrous oxide/oxygen mixture treatment of pain induced by postoperative dressing change for perianal abscess: Study protocol for a randomized, controlled trial. ( Bao, WQ; Dai, YL; Gao, HX; Gao, LL; Ge, ZM; Li, YX; Li, ZJ; Liu, Q; Meng, K; Mou, JY; Yang, Y; Yu, JQ; Zhang, JJ; Zhang, TT, 2020) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 5.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| "To assess whether inhaled nitrous oxide is noninferior to intravenous (IV) sedation for pain control during outpatient surgical abortion between 12 and 16 weeks of gestation." | 5.27 | Nitrous Oxide Compared With Intravenous Sedation for Second-Trimester Abortion: A Randomized Controlled Trial. ( Espey, E; Pitotti, J; Sheeder, J; Singh, RH; Teal, S; Thaxton, L, 2018) |
| "The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 5.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
| " Evidence regarding the effect of Nitrous oxide is limited to a small number of participants with inconsistent results on pain score and success rate." | 5.22 | Effect of nitrous oxide use on external cephalic version success rate; a systematic review and meta-analysis. ( Iskander, R; Izhaki, I; Massalha, M; Salim, R, 2022) |
| " Further research is required to determine whether the use of nitrous oxide has a role, and to develop a safe and effective analgesic strategy to fully ameliorate the pain of ROP screening." | 5.22 | Analgesia for retinopathy of prematurity screening: A systematic review. ( Hamilton, DL; Hassan, R; Savant, SV; Thirunavukarasu, AJ, 2022) |
| "The results of this study suggest that nitrous oxide inhalation combined with propofol sedation attenuates the hypotensive effect and pain associated with propofol injections, along with potentiating the amnesic effect." | 5.20 | A prospective, randomized controlled trial of conscious sedation using propofol combined with inhaled nitrous oxide for dental treatment. ( Hanamoto, H; Kudo, C; Morimoto, Y; Niwa, H; Sugimura, M; Yokoe, C, 2015) |
| "Entonox is a 50 : 50 combination of nitrous oxide and oxygen, which may be used to manage pain during colonoscopy." | 5.20 | A randomized controlled trial comparing continuous and as-required nitrous oxide use during screening colonoscopy. ( Ball, AJ; Din, S; Donnelly, M; Riley, SA, 2015) |
| "This prospective, double-blind, placebo-controlled study was designed to determine the efficacy of nitrous oxide (N(2)O) in alleviating the pain that followed sequential injection of propofol and rocuronium." | 5.17 | Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection. ( Kim, CH; Kim, E; Kim, HK; Kim, HY; Kwon, JY; Lee, DW, 2013) |
| "To determine if the addition of an inhaled equimolar mixture of nitrous oxide (N(2)O) and oxygen (EMONO) would produce superior pain relief to standard pharmacological and non-pharmacological measures during eye examination screening for retinopathy of prematurity (ROP) in premature infants." | 5.16 | Nitrous oxide analgesia during retinopathy screening: a randomised controlled trial. ( Ali, N; Chen, J; Galic, IJ; Levesque, L; Mandel, R, 2012) |
| " Due to the severity of the pain suffered, ethically it was decided to help as many as possible, so patients given the letters A, B or C were treated using a canister with the appropriate letter containing preprepared nitrous oxide/oxygen mixture (NOOM)." | 5.16 | Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain: study protocol for a randomized controlled trial. ( Guangyi, W; Guoxia, M; Hongtai, T; Jianqiang, Y; Jijun, Z; Lu, T; Ming, Y; Shichu, X; Wanfang, Z; Wannian, Z; Wen, N; Wenjun, H; Xiaoyan, H; Xiuqiang, M; Xiuying, D; Yinsheng, W; Yuxiang, L; Zhaofan, X, 2012) |
| " access, and blood sampling pain and stress affect hormone values, treatment with N(2)O or midazolam influence the glucose and stress hormone levels differently." | 5.16 | Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children. ( Ekbom, K; Jakobsson, J; Kalman, S; Marcus, C, 2012) |
| " Nitrous oxide (N(2)O) has the advantages of being a sedative agent that does not require a painful injection and that offers shallower levels of sedation and a rapid recovery of mental state." | 5.16 | A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children. ( Eun, SC; Heo, CY; Jo, YH; Kim, K; Kim, SH; Kim, TY; Lee, JH; Rhee, JE, 2012) |
| "To determine technical and clinical factors associated with pain when using an analgesic protocol with 50% nitrous oxide/oxygen and anesthetic cream (lidocaine and prilocaine, Emla(®)) for children with cerebral palsy undergoing botulinum toxin injections." | 5.15 | Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream. ( Blajan, V; Brochard, S; Garlantezec, R; Houx, L; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2011) |
| "This randomized, single-dose, double-blind, Phase III study was designed to compare the level of procedural pain after use of premixed equimolar mixture of 50% oxygen and nitrous oxide (EMONO) or placebo (premixed 50% nitrogen and oxygen)." | 5.15 | Equimolar nitrous oxide/oxygen versus placebo for procedural pain in children: a randomized trial. ( Billoët, C; de Lucas, R; Dequenne, V; García, S; Onody, P; Pascual-Pascual, SI; Reinoso-Barbero, F, 2011) |
| "To compare the effectiveness of nitrous oxide/oxygen (N(2)O/O(2)) and fentanyl in relieving pain among patients with an isolated long bone fracture or main joint dislocation of the limbs." | 5.15 | Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: a randomized trial. ( Amini, A; Derakhshanfar, H; Dolatabadi, AA; Hatamabadi, H; Kariman, H; Majidi, A; Shahrami, A; Sheibani, K; Yaseri, M, 2011) |
| "Entonox provides better pain relief and faster recovery than midazolam-fentanyl and so is more effective for colonoscopy." | 5.14 | Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy. ( Culbert, B; Duthie, GS; Gardiner, A; Hughes, M; Maslekar, S, 2009) |
| "To investigate the time of administration and concentration of inhaled nitrous oxide (N(2)O) needed to reduce the pain associated with intravenous (i." | 5.14 | The effective time and concentration of nitrous oxide to reduce venipuncture pain in children. ( Fukao, T; Furuya, A; Horimoto, Y; Ishiyama, T; Ito, M; Matsukawa, T; Nishi, M; Okuyama, K; Sato, H; Suwa, M, 2009) |
| "Whether nitrous oxide (N(2)O) increases the incidence of postoperative nausea and vomiting (PONV) after laparoscopic gynecologic surgery is still controversial, which may be due to the administration of different concentrations of inspired N(2)O." | 5.13 | The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study. ( Gan, TJ; Mraovic, B; Simurina, T; Skitarelic, N; Sonicki, Z, 2008) |
| "To compare intravenous titrated midazolam 5-10 mg and inhaled Entonox in addition to local anaesthesia in order to identify which agent provides optimum pain relief." | 5.13 | Midazolam in conjunction with local anaesthesia is superior to Entonox in providing pain relief during bone marrow aspirate and trephine biopsy. ( Allotey, D; Bratby, L; Chakupurakal, G; de la Rue, J; Delgado, J; Holder, K; Milligan, DW; Nikolousis, E; Pitchapillai, S, 2008) |
| "To compare nitrous oxide 50%/oxygen 50% (N(2)O/O(2)- entonox) plus local anaesthetic (LA) with placebo (oxygen) plus LA in the management of pain experienced by patients undergoing a bone marrow biopsy." | 5.13 | Improving the patient's experience of a bone marrow biopsy - an RCT. ( Burke, D; Johnson, H; Newell, R; Parapia, L; Plews, C, 2008) |
| " Mean +/- SD Modified Behavioral Pain Scale pain scores for EMLA, nitrous oxide/oxygen, and nitrous oxide/oxygen plus EMLA were, respectively, 9." | 5.13 | EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children. ( Annequin, D; Biran, V; Carbajal, R; Cimerman, P; Epaud, R; Fauroux, B; Gold, F; Lenclen, R; Thibault, P, 2008) |
| "To assess the efficacy of equimolar mixture of nitrous oxide/oxygen (EMNO) to prevent pain induced by venous access ports (VAPs) implantation in cancer patients." | 5.12 | Prospective, double-blind, randomized trial of equimolar mixture of nitrous oxide/oxygen to prevent pain induced by insertion of venous access ports in cancer patients. ( Bussières, L; Chevret, S; d'Agostino, P; di Palma, M; Douard, MC; Falissard, B; George, B; Kriegel, I; Misset, JL; Thierry, P, 2006) |
| "Morphine or Entonox alone are unlikely to provide adequate analgesia for chest drain removal pain in children." | 5.12 | The efficacy of morphine and Entonox analgesia during chest drain removal in children. ( Bruce, E; Franck, L; Howard, RF, 2006) |
| "Inhaled nitrous oxide (N2O) is a potent sedative-analgesic-anxiolytic agent that may relieve anxiety and discomfort during CAF ablation." | 5.12 | A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation. ( Bertaux, G; Fraison, M; Fromentin, S; Gonzalez, S; Laurent, G; Martel, A; Pierre, FS; Wolf, JE, 2006) |
| "This prospective study assessed the role of a 50:50 mixture of nitrous oxide (N2O) and oxygen for pain relief during the termination of first trimester pregnancies by suction evacuation under conscious sedation." | 5.12 | A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination. ( Caves, N; Ho, PC; Kan, AS; Ng, EH; Wong, SY, 2006) |
| "A 50% nitrous oxide/oxygen (N(2)O/O(2)) premix is widely used to alleviate pain or anxiety during brief care procedures in various medical domains." | 5.12 | Safety of inhalation of a 50% nitrous oxide/oxygen premix: a prospective survey of 35 828 administrations. ( Gil, P; Hennequin, M; Onody, P, 2006) |
| " This article summarises a survey of the use of nitrous oxide to minimise the psychological trauma and pain that was undertaken within the paediatric unit of a district general hospital (Williams et al 2004)." | 5.12 | Inhaled nitrous oxide during painful procedures: a satisfaction survey. ( Rayner, R; Richardson, K; Riley, A; Williams, V, 2006) |
| " Patients in both groups were given the option to control their pain with nitrous oxide (N(2)O) sedation administered through a nose mask as often and for as long as they wanted during the procedure." | 5.12 | The use of hypnosis to improve pain management during voluntary interruption of pregnancy: an open randomized preliminary study. ( Dodin, S; Marc, I; Masse, B; Rainville, P; Vaillancourt, L; Verreault, R, 2007) |
| "Patients experiencing pain during daily dressing changes were given entonox plus either placebo or oral transmucosal fentanyl citrate (OTFC) for two consecutive dressing changes in a randomised double-blind placebo-controlled crossover trial." | 5.12 | Oral transmucosal fentanyl citrate versus placebo for painful dressing changes: a crossover trial. ( Barker, L; Larsen, D; MacIntyre, PA; Margetts, L, 2007) |
| "Nitrous oxide inhalation significantly reduces cystoscopy related pain without significant complications." | 5.12 | Nitrous oxide inhalation to improve patient acceptance and reduce procedure related pain of flexible cystoscopy for men younger than 55 years. ( Barua, JM; Calleary, JG; Masood, J; Van-Mallaerts, R, 2007) |
| "s: The aim of the study was to evaluate the efficacy and safety of premixed 50% nitrous oxide and oxygen on the quality of sedation and pain control during fiberoptic bronchoscopy (FB) in children." | 5.11 | The efficacy of premixed nitrous oxide and oxygen for fiberoptic bronchoscopy in pediatric patients: a randomized, double-blind, controlled study. ( Clément, A; Fauroux, B; Gall, O; Koscielny, S; Onody, P; Tourniaire, B, 2004) |
| "Although the equimolecular mixture of oxygen and nitrous oxide (EMONO) seems a good choice to relieve procedure-related pain in children, it has not been evaluated for insertion of central venous catheters in children." | 5.11 | Effectiveness of fixed 50% nitrous oxide oxygen mixture and EMLA cream for insertion of central venous catheters in children. ( Abdeladhim, AB; Abdelkefi, A; Abdennebi, YB; Aouf, S; Béjaoui, M; Ladeb, S; Mellouli, F; Othman, TB; Torjman, L, 2004) |
| " lidocaine and nitrous oxide (N2O) in oxygen (O2) inhalation pre-treatment was compared with either treatment alone in the prevention of pain on propofol injection." | 5.11 | A combination of lidocaine and nitrous oxide in oxygen is more effective in preventing pain on propofol injection than either treatment alone. ( Elsaigh, I; Galvin, E; Harmon, D; Leonard, I; Niazi, A; Wahid, Z, 2005) |
| "In a randomized, double-blind, prospective trial we compared the efficacy of pre-treatment with nitrous oxide (with or without premixed lignocaine in propofol) for the prevention of propofol-induced pain." | 5.11 | Effect of nitrous oxide in reducing pain of propofol injection in adult patients. ( Neema, PK; Rathod, RC; Sinha, PK, 2005) |
| "The pretreatment with nitrous oxide is a time effective and safe method for use at paediatric outpatient departments to reduce pain, facilitate venous cannulation, and thereby reduce the number of costly cancellations of planned procedures." | 5.11 | Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments. ( Ekbom, K; Jakobsson, J; Marcus, C, 2005) |
| "To investigate if 50% nitrous oxide reduces the pain during injection of propofol mixed with lidocaine in children." | 5.10 | In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine. ( Beh, T; Kim, J; Splinter, W, 2002) |
| "Inhalation of nitrous oxide or adminstration of remifentanil attenuated pain-induced changes in CBFV(MCA)." | 5.10 | Remifentanil and nitrous oxide reduce changes in cerebral blood flow velocity in the middle cerebral artery caused by pain. ( Bauer, P; Benzer, A; Hinteregger, M; Kolbitsch, C; Lorenz, IH; Luger, TJ; Pfeiffer, KP; Schmidauer, C; Spiegel, M; Streif, W, 2003) |
| " Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0." | 5.10 | Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. ( Harmon, D; Lowe, D; Rozario, C, 2003) |
| "The authors conducted this study to compare the pain on injection of the three mandibular block techniques and to determine the effect that the delivery of nitrous oxide:oxygen, or N2O:O2, had on this pain." | 5.10 | Injection pain: comparison of three mandibular block techniques and modulation by nitrous oxide:oxygen. ( Haas, DA; Jacobs, S; May, S; Meechan, JG, 2003) |
| "To compare the effects of nitrous oxide with lidocaine on pain on injection caused by propofol in children." | 5.10 | [Prevention of pain on injection with propofol in children: comparison of nitrous oxide with lidocaine]. ( Ecoffey, C; Geslot, D; Lembert, N; Wodey, E, 2002) |
| "The efficacy of an inhaled equimolar mixture of nitrous oxide and oxygen (Entonox/MEOPA) to prevent procedural pain during renal percutaneous biopsies in children was assessed." | 5.09 | [Analgesia with oxygen-nitrous oxide mixture during percutaneous renal biopsy in children]. ( Monceaux, F; Niaudet, P; Petitjean, C; Piétrement, C; Salomon, R, 2001) |
| "The objective was to determine whether an inhaled 50:50 mixture of nitrous oxide and oxygen (N(2)O/O(2)) provides significant pain and anxiety relief during intravenous cannulation in healthy adults." | 5.09 | Inhaled nitrous oxide versus placebo as an analgesic and anxiolytic adjunct to peripheral intravenous cannulation. ( Gerhardt, RT; King, KM; Wiegert, RS, 2001) |
| "The purpose of this study was to evaluate the effect of ethyl chloride spray on the anxiety and pain associated with placing an intravenous catheter in patients sedated with nitrous oxide." | 5.09 | Venous cannulation and topical ethyl chloride in patients receiving nitrous oxide. ( Beirne, OR; Crecelius, C; Rouhfar, L, 1999) |
| " Desflurane, with the characteristics of rapid onset and minimal metabolism, may provide better analgesia and safety for labour pain control." | 5.08 | Desflurane analgesia for vaginal delivery. ( Abboud, TK; Donovan, MM; Peres Da Silva, E; Swart, F; Yakal, K; Zhu, J, 1995) |
| "kg-1 propofolis not effective in the treatment of postoperative vomiting in children after adenotonsillectomy when a standardized anaesthetic with thiopentone, halothane, nitrous oxide, and 1." | 5.08 | Subhypnotic propofol does not treat postoperative vomiting in children after adenotonsillectomy. ( Carr, AS; Lerman, J; McAuliffe, G; Sikich, N; Smith, HS; Zestos, MM, 1997) |
| "To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group." | 5.08 | [Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998) |
| "We have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique." | 5.08 | Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain. ( Arendt-Nielsen, L; Curatolo, M; Luginbühl, M; Petersen-Felix, S; Schnider, TW; Zbinden, AM, 1998) |
| " Acetaminophen and meperidine were given for postoperative pain." | 5.07 | Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994) |
| "To compare carbon dioxide and nitrous oxide pneumoperitoneum with respect to intraoperative and postoperative pain during laparoscopic sterilization under local anesthesia." | 5.07 | The effect of nitrous oxide and carbon dioxide pneumoperitoneum on operative and postoperative pain during laparoscopic sterilization under local anesthesia. ( Ling, FW; Lipscomb, GH; McCord, ML; Summitt, RL, 1994) |
| "A clinical trial of a 50:50 mixture of nitrous oxide and oxygen for pain relief was carried out to determine the feasibility of its use in a field setting and the side-effects produced by this sedative/analgesic." | 5.05 | Patient-controlled inhalational analgesia in prehospital care: a study of side-effects and feasibility. ( Cannon, G; Paris, PM; Stewart, RD; Stoy, WA, 1983) |
| " Patients in whom anesthesia was induced with etomidate had a greater incidence of pain on injection and myoclonus and a lesser incidence of apnea than patients in whom anesthesia was induced with thiopental." | 5.05 | Etomidate versus thiopental for induction of anesthesia. ( Giese, JL; Nelissen, RH; Pace, NL; Stanley, TH; Stockham, RJ, 1985) |
| "The analgesic effect of self-administered nitrous oxide 50%/oxygen 50% ('Entonox" analgesic apparatus) was compared with air given by the same method in a double-blind trial in 81 patients with myocardial infarction." | 5.04 | A double-blind trial of patient-controlled nitrous-oxide/oxygen analgesia in myocardial infarction. ( Brown, MG; Ewing, DJ; Hoskins, MR; Irving, JB; Kerr, F; Kirby, BJ, 1975) |
| "Nitrous oxide in a concentration of 35% has been shown to ameliorate the pain of acute myocardial infarction." | 5.04 | Nitrous oxide as an analgesic in acute myocardial infarction. ( Lown, B; Thompson, PL, 1976) |
| "Nitrous oxide is an effective sedative/analgesic for mildly to moderately painful paediatric procedures." | 4.89 | Nitrous oxide provides safe and effective analgesia for minor paediatric procedures--a systematic review. ( Bayat, A; Jacobsson, ML; Pedersen, RS; Steen, NP, 2013) |
| "The primary objective was to compare the overall effectiveness of nitrous oxide mixtures to other types of pain relief used during colonoscopy procedures to provide adequate pain/discomfort relief." | 4.87 | Nitrous oxide for colonoscopy. ( Aboumarzouk, OM; Agarwal, T; Milewski, PJ; Nelson, RL; Syed Nong Chek, SA, 2011) |
| "Morphine alone does not provide satisfactory analgesia for chest drain removal pain." | 4.83 | Chest drain removal pain and its management: a literature review. ( Bruce, EA; Franck, LS; Howard, RF, 2006) |
| "Nitrous oxide may be used to alleviate dental anxiety and to diminish or eliminate dental pain." | 4.81 | Environmental health risk of chronic exposure to nitrous oxide in dental practice. ( Szymańska, J, 2001) |
| "Systemic labour pain treatment with opioids and inhaled nitrous oxide has for many decades frequently been used in medically developed countries." | 4.80 | Traditional analgesic agents: are parenteral narcotics passé and do inhalational agents still have a place in labour? ( Irestedt, L; Olofsson, C, 1998) |
| " However, its analgesic efficacy remains uncertain for painful procedures; therefore, a combination with intranasal fentanyl (INF), an opioid, was suggested." | 3.91 | Nitrous Oxide 70% for Procedural Analgosedation in a Pediatric Emergency Department-With or Without Intranasal Fentanyl? ( Landolt, MA; Seiler, M; Staubli, G, 2019) |
| "Numerous reports describe the successful use of nitrous oxide for analgesia in children undergoing painful procedures." | 3.85 | Successful use of nitrous oxide during lumbar punctures: A call for nitrous oxide in pediatric oncology clinics. ( Lawell, M; Livingston, M; McAllister, N, 2017) |
| "MEOPA (equimolar mixture of oxygen and nitrous oxide) is used for its analgesic and anxiolytic properties in order to obtain conscious sedation of the patient when performing painful care." | 3.85 | [MEOPA use practices in a university hospital: Which conformity?] ( Cosset, C; Jolliet, P; Joyau, C; Kuhn, E; Le Pelletier, A; Nizard, J; Paille, C; Veyrac, G; Victorri-Vigneau, C, 2017) |
| " We wanted to study whether nitrous oxide/oxygen (NOO, Livopan(®), Linde Gas Therapeutics, Unterschleißheim, Germany) can reduce ISP in patients receiving intracutaneous BT injections for axillary or palmar hyperhidrosis (HH)." | 3.81 | Botulinum toxin therapy for hyperhidrosis: reduction of injection site pain by nitrous oxide/oxygen mixtures. ( Dengler, R; Dressler, D; Kollewe, K; Paracka, L, 2015) |
| "The Livopan study is a prospective, single-centre, explorative, controlled, observational study to investigate the pain reduction in patients after applying a nitrous oxide/oxygen mixture (Livopan) during PDT according to the visual analogue scale in 60 patients." | 3.81 | Pain reduction in patients after applying a nitrous oxide/oxygen mixture (Livopan) during photodynamic therapy: study protocol for an observational study (Livopan study). ( Enk, A; Fink, C; Gholam, P; Uhlmann, L, 2015) |
| " However, persisting neurological signs despite adequate treatment lately led to diagnose subacute combined medullar degeneration due to abnormal cobalamin (vitamin B12) metabolism induced by repeated use of nitrous oxide during painful episodes of sickle-cell disease." | 3.80 | [Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration]. ( Cabral, D; Chaugny, C; Collin-Masson, H; De Beauchêne, M; Fagniez, O; Simon, J; Veyssier-Belot, C, 2014) |
| "Using the rat chronic constriction injury (CCI) pain model, we evaluated whether nitrous oxide (N2O), a gas shown to have potent anti-hyperalgesic properties, may alleviate neuropathic pain." | 3.76 | A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. ( Bessière, B; Chateauraynaud, J; Laboureyras, E; Laulin, JP; Simonnet, G, 2010) |
| " In contrast, pain intensity evaluated by the patient tended to be lower in the Entonox group (mean VAS: 2." | 3.74 | [Value of nitrous oxide-oxygen mixture (Entonox) in transrectal prostate biopsies]. ( Dubruille, T; Michel, F; Spie, R; Watfa, J, 2008) |
| "The limited potency of nitrous oxide mandates the use of a hyperbaric chamber to produce anesthesia." | 3.74 | A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber. ( Antognini, JF; Atherley, RJ; Carstens, E; Dutton, RC; Eger, EI; Laster, MJ, 2007) |
| "This report examines the pain-related pupil dilation response (PDR), tracking it across mixture concentrations of nitrous oxide (N(2)O) in oxygen (O(2)) and relating its variation to change in long latency somatosensory evoked potentials (SEPs) and visual analogue scale (VAS) pain report." | 3.74 | Pupil dilation response to noxious stimulation: effect of varying nitrous oxide concentration. ( Chapman, CR; Kim, B; Nakajima, I; Oi, Y; Oka, S; Shimizu, O, 2007) |
| "Nitrous oxide gas, mixed 50:50 with oxygen, is an effective and safe analgesic which, although widely used in many areas of clinical practice, has not been fully recognized in the community setting for painful procedures." | 3.72 | Use of Entonox in the community for control of procedural pain. ( Evans, A, 2003) |
| "Between 1st April 1997 and 31st March 1998, children who had to undergo a painful procedure were proposed to inhale 50% nitrous oxide before the procedure." | 3.70 | [Utilization of an equimolar mixture of oxygen-nitrous oxide in a general pediatric ward]. ( Blayo, M; Blondin, G; Broussine, L; Laguette, D; Lew, J; Mehu, G; Queinnec, C; Thirion, S; Vic, P, 1999) |
| "Although the equimolecular mixture of oxygen and nitrous oxide (EMONO) seems a good choice to relieve procedure-related pain in children, it has not been accepted everywhere." | 3.70 | Fixed 50% nitrous oxide oxygen mixture for painful procedures: A French survey. ( Annequin, D; Carbajal, R; Chauvin, P; Gall, O; Murat, I; Tourniaire, B, 2000) |
| " with formalin, behavioural correlates of the amount and pattern of Fos-like immunoreactivity (Fos-Ll) (molecular responses to pain) were studied to test if early phase treatment with 75% nitrous oxide or 2% halothane, or both, suppressed subsequent spinal sensitization." | 3.69 | Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin. ( Shieh, JY; Shyu, BC; Sun, WZ, 1996) |
| "Entonox, a nitrous oxide/oxygen gas widely used as an analgesic in child-bith, can be used for other patients undergoing a variety of painful procedures." | 3.69 | Entonox: too useful to be limited to childbirth? ( Lawler, K, 1995) |
| "Significant changes were found for pain assessment, local anesthesia procedures, and nitrous oxide administration." | 3.69 | [Pain in lumbar puncture. Results of a 2-year discussion at the French Society of Pediatric Oncology]. ( Annequin, D; Bouffet, E; Castaing, MC; Douard, MC; Pichard-Léandri, E, 1996) |
| "Nitrous oxide-pain interactions were studied by comparing regional cerebral blood flow responses to a 48 degrees C tonic heat stimulus, applied to each volunteer's left forearm, during room air inhalation with those obtained while 20% nitrous oxide was administered." | 3.69 | In vivo imaging of nitrous oxide-induced changes in cerebral activation during noxious heat stimuli. ( Firestone, LL; Gyulai, FE; Mintun, MA; Winter, PM, 1997) |
| "The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered." | 3.67 | Cognitive modification of pain: information in combination with N2O. ( Chen, ACN; Clark, DW; Dworkin, SF; Schubert, MM, 1984) |
| "The effect of 33% nitrous oxide/67% oxygen was compared with 100% oxygen and air on verbal reports of either sensory intensity or unpleasantness of sensations associated with painful electrical tooth pulp stimulation." | 3.67 | Nitrous oxide analgesia: a psychophysical evaluation using verbal descriptor scaling. ( Dubner, R; Gracely, RH; Heft, MW, 1984) |
| "Combinations of transcutaneous electrical stimulation (TES) and inhalation of nitrous oxide with oxygen have been used for surgical pain control and this report explored the possible synergism of these two treatments." | 3.66 | Effects of nitrous oxide, transcutaneous electrical stimulation, and their combination on brain potentials elicited by painful stimulation. ( Chapman, CR; Colpitts, YH; Gehrig, JD; Gerlach, R; Schimek, F, 1983) |
| "Effects of inhaling three levels of nitrous oxide in oxygen on event-related brain potentials (ERPs) and pain report were examined in 10 volunteers undergoing painful electrical stimulation of tooth pulp." | 3.66 | Effect of nitrous oxide concentration on event-related potentials during painful tooth stimulation. ( Benedetti, C; Chapman, CR; Chen, AC; Colpitts, YH, 1982) |
| "The analgesic effectiveness of 50% nitrous oxide and oxygen or oxygen-enriched air, measured by variations in pain threshold, was studied at an altitude of 1460 m and simulated altitudes of sea level and 3300 m." | 3.66 | Nitrous oxide analgesia and altitude. ( Dennett, JE; James, MF; Manson, ED, 1982) |
| "The effects of 50% nitrous oxide and 50% oxygen and of 30% nitrous oxide and 70% oxygen were evaluated in 88 patients with significant pain while in the prehospital setting." | 3.66 | Prehospital administration of nitrous oxide for control of pain. ( Amey, BD; Ballinger, JA; Harrison, EE, 1981) |
| "Analgesia with a mixture containing 50% nitrous oxide and 50% oxygen (Nitronox) was evaluated in 47 patients with abdominal pain, chest pain, musculoskeletal trauma, and burns." | 3.66 | Self-administered analgesia with nitrous oxide. Adjunctive aid for emergency medical care systems. ( Atkins, JM; Montgomery, SJ; Roberts, BG; Thal, ER, 1979) |
| "The continuous administration of nitrous oxide, in subjects who remain conscious, caused only a relatively small increase in the threshold of appreciation of pain, induced experimentally by tibial pressure and a hot wire applied to the thenar eminence." | 3.65 | Pain during continuous nitrous oxide administration. ( Hall, GM; Morgan, M; Petrie, A; Whitwam, JG, 1976) |
| " For unanesthetized tubes the mean pain rating depended on the dose of diazepam and fentanyl given to the patient (p less than ." | 3.65 | Laparoscopic tubal clip sterilization under local anesthesia. ( Edelman, DA; Fishburne, JI; Hulka, JF; Mercer, JP; Omran, KF, 1974) |
| "Patients with renal lithiasis were included and were randomized to Group A (basal analgesia: midazolam (1 mg), fentanyl (0." | 3.11 | Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL). ( Alcoba-García, MP; Bueno-Serrano, G; González-Enguita, C; González-López, R; Llanos-Jiménez, L; Mahillo-Fernández, I; Tabares-Jiménez, J, 2022) |
| "AMSA and P-ASA approaches were used with CIT." | 2.79 | Pain sensation and injection techniques in maxillary dento-alveolar surgery procedures in children--a comparison between conventional and computerized injection techniques (The Wand). ( Jälevik, B; Klingberg, G, 2014) |
| "Pain was evaluated by patients before and after the procedure using a Visual Analog Scale." | 2.76 | Evaluation of analgesic effect of equimolar mixture of oxygen and nitrous oxide inhalation during percutaneous biopsy of focal liver lesions: a double-blind randomized study. ( d'Assignies, G; Meskine, N; Sibert, A; Vilgrain, V; Vullierme, MP; Zappa, M, 2011) |
| "Pain was graded from 1 (no pain) to 4 (severe pain)." | 2.76 | Nitrous oxide for analgesia in colonoscopy without sedation. ( Aabakken, L; Bretthauer, M; Furholm, S; Hoff, G; Hoff, I; Løberg, M, 2011) |
| "Pain was recorded on 100 mm visual analogue scales (VAS) after lignocaine injection or ethyl chloride spray and following i." | 2.73 | Lignocaine is a better analgesic than either ethyl chloride or nitrous oxide for peripheral intravenous cannulation. ( Carr, S; Frampton, C; Pearson, S; Robinson, PA, 2007) |
| "morphine during painful bedsore and ulcer care in adult and elderly patients, we conducted a randomized, crossover, multicenter, prospective, open-label, pilot study." | 2.73 | Nitrous oxide-oxygen mixture during care of bedsores and painful ulcers in the elderly: a randomized, crossover, open-label pilot study. ( Basset, P; Bosson, JL; Couturier, P; Franco, A; Horvath, R; Paris, A; Thiery, S, 2008) |
| "Nitrous oxide was beneficial during incidents in five of seven patients; the remaining two patients reported an overall preference for the nitrous oxide day." | 2.71 | Self-administered nitrous oxide for the management of incident pain in terminally ill patients: a blinded case series. ( Dudgeon, DJ; Griffiths, JM; Milne, B; Parlow, JL; Stewart, GI; Tod, DA, 2005) |
| "Six patients with uncontrolled cancer-related pain were studied." | 2.68 | Patient-controlled analgesia with nitrous oxide in cancer pain. ( Keating, HJ; Kundrat, M, 1996) |
| "Isoflurane 0." | 2.67 | Isoflurane in labour. ( Hasan, MA; Thomas, TA; Wee, MY, 1993) |
| "Frequent blisters appear spontaneously, and are often preceded by erythema and itching." | 1.72 | Procedural analgesia with nitrous oxide at home for epidermolysis bullosa: A case report. ( Annicchiarico, G; Attolini, E; Dipietro, G; Laterza, C; Murciano, M; Rubino, A; Storelli, S, 2022) |
| "Nitrous oxide may increase the success of the IANB." | 1.62 | Nitrous Oxide/Oxygen Effect on IANB Injection Pain and Mandibular Pulpal Anesthesia in Asymptomatic Subjects. ( Dds, MB; Drum, M; Fowler, S; Kushnir, B; Nusstein, J; Reader, A, 2021) |
| "Nitrous oxide was available for the first 5 months studied, followed by 6 months methoxyflurane availability." | 1.62 | Frequency and duration of ambulance officer exposure to nitrous oxide and methoxyflurane in New Zealand. ( Allison, SJ; Chase, JG; Docherty, PD; Pons, D, 2021) |
| "Sevoflurane MAC was not significantly reduced by N2O and its antinociceptive action was almost completely abolished in KOP-knockout (KO) mice." | 1.40 | κ-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice. ( Fukagawa, H; Fukuda, K; Koyama, T, 2014) |
| "Nalbuphine was the most commonly used opioid for moderate PVOE and morphine for severe PVOE." | 1.40 | How French paediatric emergency departments manage painful vaso-occlusive episodes in sickle cell disease patients. ( Carbajal, R; Courtois, E; Galeotti, C, 2014) |
| "Nitrous oxide was effective in inducing anesthesia in neonatal piglets during handling." | 1.37 | Nitrous oxide by itself is insufficient to relieve pain due to castration in piglets. ( Lay, DC; Rault, JL, 2011) |
| "Nitrous oxide (N(2)O) is an attractive agent for procedural analgesia and sedation of children in the emergency department (ED)." | 1.35 | Limited analgesic efficacy of nitrous oxide for painful procedures in children. ( Babl, FE; Oakley, E; Puspitadewi, A; Sharwood, LN, 2008) |
| "Nitrous oxide is an effective analgesic when performing bone-marrow biopsies." | 1.35 | [Pain prevention with fixed 50% nitrous oxide-oxygen mixture during bone-marrow biopsy]. ( Bernit, E; Gayet, S; Harlé, JR; Kaplanski, G; Mazodier, K; Sati, H; Schleinitz, N; Veit, V, 2009) |
| "Pain was evaluated with the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS), the Visual Analogue Scale (VAS) and the Face Pain Scale (FPS) for the children and with a VAS for the parents." | 1.35 | Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children. ( Blajan, V; Brochard, S; Le Moine, P; Lefranc, J; Lempereur, M; Peudenier, S; Rémy-Néris, O, 2009) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 1.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| "After obtaining institutional approval, antinociceptive dose-response and time-course to N2O was measured in wild-type and transgenic mice (D79N), with a nonfunctional alpha2A adrenoceptor using tail-flick latency." | 1.30 | Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. ( Davies, MF; Guo, TZ; Kingery, WS; Limbird, LE; Maze, M; Patterson, AJ, 1999) |
| "Nitrous oxide is a gas that has been used to provide analgesia to patients for more than a century." | 1.30 | [Analgesia using a (50/50) mixture of nitrous oxide/oxygen in children]. ( Carbajal, R, 1999) |
| "If emergency physicians would treat the pain of their patients as they would want it to be treated in themselves or their families, then we will have made great strides as a specialty in mastering the art and science of analgesia." | 1.27 | Pain management in the child. ( Paris, PM, 1987) |
| "The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 1.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 121 (36.23) | 18.7374 |
| 1990's | 44 (13.17) | 18.2507 |
| 2000's | 87 (26.05) | 29.6817 |
| 2010's | 66 (19.76) | 24.3611 |
| 2020's | 16 (4.79) | 2.80 |
| Authors | Studies |
|---|---|
| Murciano, M | 1 |
| Laterza, C | 1 |
| Attolini, E | 1 |
| Storelli, S | 1 |
| Dipietro, G | 1 |
| Rubino, A | 1 |
| Annicchiarico, G | 1 |
| Massalha, M | 1 |
| Izhaki, I | 1 |
| Iskander, R | 1 |
| Salim, R | 2 |
| Thirunavukarasu, AJ | 1 |
| Hassan, R | 1 |
| Savant, SV | 1 |
| Hamilton, DL | 1 |
| Friedrichsdorf, SJ | 2 |
| Bueno-Serrano, G | 1 |
| Alcoba-García, MP | 1 |
| Tabares-Jiménez, J | 1 |
| González-López, R | 1 |
| Llanos-Jiménez, L | 1 |
| Mahillo-Fernández, I | 1 |
| González-Enguita, C | 1 |
| Tran, J | 1 |
| Lultschik, S | 1 |
| Sapra, S | 1 |
| Dong, K | 1 |
| Zuarez-Easton, S | 1 |
| Zafran, N | 1 |
| Garmi, G | 1 |
| Dagilayske, D | 1 |
| Inbar, S | 1 |
| Wang, Z | 1 |
| Wang, F | 1 |
| Xing, Y | 1 |
| Jiang, X | 1 |
| Ding, Z | 1 |
| Li, Y | 1 |
| Tang, L | 1 |
| Maiandi, S | 1 |
| Ghizzardi, G | 1 |
| Edefonti, V | 1 |
| Giacchero, R | 1 |
| Lusignani, M | 1 |
| Giannì, ML | 1 |
| Tieri, M | 1 |
| Cosi, A | 1 |
| Lombardi, L | 1 |
| De Icco, V | 1 |
| D Ercole, S | 1 |
| Ferdeghini, R | 1 |
| Tripodi, D | 1 |
| Fan, TT | 1 |
| Han, M | 1 |
| Liang, Y | 1 |
| Cao, GH | 1 |
| Song, GD | 1 |
| Zhang, JJ | 1 |
| Gao, HX | 1 |
| Zhang, TT | 1 |
| Bao, WQ | 1 |
| Mou, JY | 1 |
| Meng, K | 1 |
| Dai, YL | 1 |
| Gao, LL | 1 |
| Liu, Q | 1 |
| Li, ZJ | 1 |
| Ge, ZM | 1 |
| Yang, Y | 1 |
| Yu, JQ | 1 |
| Li, YX | 1 |
| Straube, LE | 1 |
| Fardelmann, KL | 1 |
| Penwarden, AA | 1 |
| Chen, F | 1 |
| Harker, E | 1 |
| Redmon, BF | 1 |
| Li, Q | 1 |
| Strauss, R | 1 |
| Smith, KA | 1 |
| Arnold, WR | 1 |
| Carnevale, LN | 1 |
| Xie, Z | 1 |
| Baylon, JL | 1 |
| Tajkhorshid, E | 1 |
| Hu, H | 1 |
| Das, A | 1 |
| Kushnir, B | 1 |
| Fowler, S | 1 |
| Drum, M | 1 |
| Nusstein, J | 1 |
| Reader, A | 1 |
| Dds, MB | 1 |
| Allison, SJ | 1 |
| Docherty, PD | 1 |
| Pons, D | 1 |
| Chase, JG | 1 |
| Johnson, OG | 1 |
| Taylor, DM | 1 |
| Lee, M | 1 |
| Ding, JL | 1 |
| Ashok, A | 1 |
| Johnson, D | 1 |
| Peck, D | 1 |
| Knott, J | 1 |
| Weinberg, L | 1 |
| Livingston, M | 2 |
| Lawell, M | 1 |
| McAllister, N | 1 |
| Ingelmo, P | 1 |
| Wei, A | 1 |
| Rivera, G | 1 |
| Victorri-Vigneau, C | 3 |
| Paille, C | 1 |
| Joyau, C | 1 |
| Veyrac, G | 1 |
| Cosset, C | 1 |
| Le Pelletier, A | 1 |
| Jolliet, P | 2 |
| Nizard, J | 1 |
| Kuhn, E | 1 |
| Paracka, L | 2 |
| Kollewe, K | 2 |
| Wegner, F | 1 |
| Dressler, D | 2 |
| Seiler, M | 1 |
| Landolt, MA | 1 |
| Staubli, G | 1 |
| Dong, T | 1 |
| Liu, M | 1 |
| Lv, K | 1 |
| Forster, V | 1 |
| Escherich, G | 1 |
| Halsey, C | 1 |
| Bostrom, B | 1 |
| McAllister, NR | 1 |
| Thaxton, L | 1 |
| Pitotti, J | 1 |
| Espey, E | 1 |
| Teal, S | 1 |
| Sheeder, J | 1 |
| Singh, RH | 1 |
| Katsogiannou, M | 1 |
| Donato, XC | 1 |
| Loundou, A | 1 |
| Glowaczower, E | 1 |
| Raffray, M | 1 |
| Planchet-Barraud, B | 1 |
| Quarello, E | 1 |
| Brechard, MP | 1 |
| Desbriere, R | 1 |
| Doersch, KM | 1 |
| Machen, GL | 1 |
| Thai, KH | 1 |
| Sung, J | 1 |
| El Tayeb, MM | 1 |
| Gillman, MA | 4 |
| Prud'homme, T | 1 |
| Dajean-Trutaud, S | 1 |
| Rousselet, M | 2 |
| Feuillet, F | 2 |
| Carpentier-Cheraud, M | 1 |
| Bonnot, O | 2 |
| Hyon, I | 1 |
| Grall-Bronnec, M | 2 |
| Lopez-Cazaux, S | 1 |
| Delgove, A | 1 |
| Harper, L | 1 |
| Berciaud, S | 1 |
| Lalioui, A | 1 |
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| Almenrader, N | 1 |
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| Steen, NP | 1 |
| Jacobsson, ML | 1 |
| Chaugny, C | 1 |
| Simon, J | 1 |
| Collin-Masson, H | 1 |
| De Beauchêne, M | 1 |
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| Veyssier-Belot, C | 1 |
| Kim, E | 1 |
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| Lee, DW | 1 |
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| Barnay, P | 1 |
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| Krebs, G | 1 |
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| Koyama, T | 3 |
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| Jälevik, B | 1 |
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| Carbajal, R | 5 |
| Lyke, A | 1 |
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| Hanamoto, H | 1 |
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| Kudo, C | 1 |
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| Couec, ML | 1 |
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| Perrouin, F | 1 |
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| Bailey, B | 1 |
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| Sutter, C | 1 |
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| Spie, R | 1 |
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| JAMISON, R | 1 |
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| Sharwood, LN | 1 |
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| Rault, JL | 1 |
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| TOMPA, F | 1 |
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| BERGSTROEM-WALAN, MB | 1 |
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| Koscielny, S | 1 |
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| Chapman, CR | 7 |
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| Plews, C | 1 |
| Newell, R | 1 |
| Parapia, L | 1 |
| Gudgin, EJ | 1 |
| Besser, MW | 1 |
| Craig, JI | 1 |
| Paris, A | 1 |
| Horvath, R | 1 |
| Basset, P | 1 |
| Thiery, S | 1 |
| Couturier, P | 1 |
| Franco, A | 1 |
| Bosson, JL | 1 |
| Lindman, N | 1 |
| Anderson, RE | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrous Oxide Versus Intravenous Sedation for Anesthesia[NCT02755090] | 39 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| Multicentre, Prospective, Uncontrolled Study to Describe the Present, Felt and Sought Effects of EMONO in Children During Dental Care[NCT03453411] | 679 participants (Actual) | Observational | 2018-05-17 | Completed | |||
| Efficacy of External Cold and a Vibrating Device in Reducing Discomfort of Dental Injections in Children - A Split Mouth Randomized Clinical Trial[NCT02675387] | 60 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the Pediatric Emergency Department: a Double Blind Randomized Versus Placebo Controlled Trial[NCT06181695] | Phase 3 | 182 participants (Anticipated) | Interventional | 2024-05-02 | Not yet recruiting | ||
| Optimizing the Use of Entonox® During Screening Colonoscopy: an Open Randomised Controlled Trial[NCT01865721] | Phase 4 | 100 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| PHEDRE Trial Protocol - Observational Study of the Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) and Analgesics in the French Sickle-cell Disease Population[NCT02580565] | 1,004 participants (Actual) | Observational | 2015-09-25 | Completed | |||
| Comparing Pain Relief in Early Labor: Nitrous Oxide Versus Butorphonol Study[NCT01636999] | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn | |||
| Evaluation of the Effect of the Presence Of Clowns on Pain and Anxiety Seen During Injections Botulinum Toxin in Child[NCT03149263] | 80 participants (Actual) | Observational | 2015-11-10 | Completed | |||
| A Randomized Controlled Trial on the Effectiveness of Inhaled Nitrous Oxide for Pain Relief During ROP Screening Exam in the Pre-term Infant[NCT00623220] | Phase 3 | 40 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial[NCT00318825] | Phase 4 | 200 participants (Anticipated) | Interventional | 2006-04-30 | Completed | ||
| Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion[NCT03751423] | Phase 3 | 123 participants (Anticipated) | Interventional | 2019-06-10 | Suspended (stopped due to Study on-hold due to COVID-19 pandemic restrictions. Will resume when possible.) | ||
| A Pilot Randomized Controlled Crossover Trial of the Effectiveness of Disposable Nitrous Oxide Canisters in Providing Improved Pain Control During Burn Dressing Changes.[NCT03695887] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2019-10-01 | Recruiting | ||
| Validity of Bispectral Index Monitoring During Deep Sedation for Botulinum Toxin Injection in Children With Cerebral Palsy[NCT02096549] | 22 participants (Actual) | Observational | 2014-03-31 | Completed | |||
| Comparison of N2O Inhalation and Ketamine IV Injection for Sedation in the Treatment of Laceration of Pediatric Patients.[NCT00834730] | Phase 4 | 32 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| The Effect of Touch on Pain and Anxiety During the Bone Marrow Biopsy Procedure[NCT04935775] | 46 participants (Actual) | Interventional | 2021-10-13 | Completed | |||
| Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement[NCT02696460] | 21 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Analgesic Efficacy and Safety of Nalbuphine Versus Morphine for Perioperative Tumor Ablation: a Randomized, Control, Multicentre Trial[NCT05073744] | Phase 4 | 316 participants (Anticipated) | Interventional | 2021-09-05 | Recruiting | ||
| An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366] | Phase 4 | 121 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017] | Phase 4 | 0 participants (Actual) | Interventional | 2020-11-01 | Withdrawn (stopped due to Sponsoring staff have left institution) | ||
| Evaluation of the Analgesy Using a Local Anesthetic (Lidocaine and Prolocaine) Eutectic Mixture and/or Nitric Oxide at 50% in Oxygen (Livopan®) in Pediatric Patients That During Lumbar Puncture[NCT00808171] | Phase 4 | 52 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651] | Phase 1 | 20 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| MEOPA Breathing Analgesia vs Local Anesthesia for Oocyte Retrieval in ART: a Prospective, Randomized Controlled Study[NCT00853177] | Phase 4 | 77 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Efficacy and Safety of Methoxyflurane Vaporized (PENTHROX®) in the Treatment of Acute Trauma Pain in Pre-hospital Setting and in the Emergency Department in Italy: a Multicentre, Randomized, Controlled, Open-label Study[NCT03585374] | Phase 3 | 272 participants (Actual) | Interventional | 2018-02-08 | Completed | ||
| Single-dose Potassium Supplementation in ADHD Patients With Lidocaine Ineffectiveness[NCT03563573] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2018-07-01 | Enrolling by invitation | ||
| Prevalence of Lidocaine Ineffectiveness in Those With Hard-to-treat ADHD[NCT04167189] | Early Phase 1 | 28 participants (Actual) | Interventional | 2018-01-20 | Completed | ||
| Reliability Testing of a Non-invasive, Pain-free, Taste-based Assessment Approach to Lidocaine Effectiveness[NCT03680885] | Early Phase 1 | 20 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Assessing the Frequency of Lidocaine Ineffectiveness in the General Population vs. Males With ADHD, and Females With ADHD, With or Without PMS[NCT03676725] | Early Phase 1 | 90 participants (Actual) | Interventional | 2019-08-14 | Completed | ||
| iPad as a Distraction Tool During Facial Laceration Repair[NCT02217436] | 80 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| Optimal Lidocaine Propofol Mixture for Painless Induction of Anesthesia[NCT05898061] | 100 participants (Anticipated) | Observational [Patient Registry] | 2023-03-01 | Recruiting | |||
| The Effect of Different Applications of Tourniquet on Total Knee Arthroplasty[NCT03256058] | 60 participants (Anticipated) | Interventional | 2017-08-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Iowa Satisfaction with Anesthesia Scale (ISAS) was given to women following a surgical abortion. The ISAS score is the mean of 11 responses to questions regarding satisfaction with anesthesia and has a score range of -3 (disagree strongly) to 3 (agree strongly). (NCT02755090)
Timeframe: Assessed 30 minutes after procedure completion.
| Intervention | units on a scale (Mean) |
|---|---|
| Nitrous Oxide and IV Saline | 0.7 |
| Standard Care Group (IV Sedation and Oxygen) | 1.8 |
To compare women's maximum procedural pain measured on a visual analog scale (VAS) during a surgical abortion between 12 weeks 0 days to 16 weeks 0 days gestational age between women randomized to nitrous oxide versus intravenous sedation. A score of 0 represents no pain and a score of 100 represents pain as bad as it could be. (NCT02755090)
Timeframe: Assessed immediately following completion of the procedure (as defined as removal of the speculum)
| Intervention | units on a scale (Mean) |
|---|---|
| Nitrous Oxide and IV Saline | 54.1 |
| Standard Care Group (IV Sedation and Oxygen) | 34.0 |
Weighted average Observational Score Behavioral Distress Revised (OSBD-R) scored from videotapes of the entire laceration repair procedure Scale 0-23.5 (0 low/better, 23.5 high/worse) (NCT02217436)
Timeframe: Entire laceration repair procedure
| Intervention | units on a scale (Median) |
|---|---|
| iPad | 2.3 |
| Standard Care | 0.8 |
Parent rating of own anxiety during the procedure Likert-based scale 1-5 (1 low/better, 5 high/worse) (NCT02217436)
Timeframe: Survey administered immediately following the laceration repair
| Intervention | score on a scale (Median) |
|---|---|
| iPad | 2 |
| Standard Care | 4 |
29 reviews available for nitrous oxide and Ache
| Article | Year |
|---|---|
Effect of nitrous oxide use on external cephalic version success rate; a systematic review and meta-analysis.
Topics: Breech Presentation; Female; Humans; Nitrous Oxide; Pain; Pregnancy; Prospective Studies; Version, F | 2022 |
Analgesia for retinopathy of prematurity screening: A systematic review.
Topics: Acetaminophen; Analgesia; Fentanyl; Humans; Infant, Newborn; Nitrous Oxide; Pain; Pain Measurement; | 2022 |
Efficacy of nitrous oxide in adults undergoing puncture biopsy: A systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Analgesics; Biopsy, Needle; Humans; Nitrous Oxide; Pain; Randomized Controlled Trials as Topi | 2023 |
Mini-Review: A Brief History of Nitrous Oxide (N2O) Use in Neuropsychiatry.
Topics: Anesthesia, Dental; Anesthetics, Inhalation; Anti-Anxiety Agents; Anxiety; Humans; Nitrous Oxide; Pa | 2019 |
Nitrous oxide provides safe and effective analgesia for minor paediatric procedures--a systematic review.
Topics: Adolescent; Analgesia; Analgesics, Non-Narcotic; Catheterization, Peripheral; Child; Child, Preschoo | 2013 |
Pharmacotherapy for acute pain in children: current practice and recent advances.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, | 2011 |
Pain relief in the treatment of shoulder injury.
Topics: Analgesics; Conscious Sedation; Humans; Hypnotics and Sedatives; Midazolam; Morphine; Nitrous Oxide; | 2011 |
Nitrous oxide for colonoscopy.
Topics: Analgesia; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, Combined; Colonoscopy; | 2011 |
[Pain management in Stevens-Johnson syndrome, toxic epidermal necrolysis and other blistering diseases].
Topics: Analgesics; Anti-Anxiety Agents; Combined Modality Therapy; Disease Management; Drug Therapy, Combin | 2011 |
A systematic review of interventions for reducing pain and distress in children undergoing voiding cystourethrography.
Topics: Anesthetics, Inhalation; Anxiety; Child; Fluoroscopy; Hot Temperature; Humans; Hypnotics and Sedativ | 2012 |
[Sedation and analgesia in emergency structure. Paediatry: Which sedation and analgesia for the child under spontaneous ventilation?].
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, D | 2012 |
Analgesia without sedatives during colonoscopies: worth considering?
Topics: Alfentanil; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Colonoscopy; Humans; Nitrous Ox | 2012 |
[Utilization of Meopa to ease pain].
Topics: Analgesics, Non-Narcotic; Anesthesia, Inhalation; Contraindications; Humans; Monitoring, Physiologic | 2012 |
Strategies of pain reduction during the bone marrow biopsy.
Topics: Analgesics; Anesthesia, Inhalation; Anesthesia, Local; Anti-Anxiety Agents; Anxiety; Biopsy, Needle; | 2013 |
Chest drain removal pain and its management: a literature review.
Topics: Adult; Age Factors; Analgesia; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; Anti-I | 2006 |
Management of pain in childhood.
Topics: Acetaminophen; Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Local; | 2007 |
Traditional analgesic agents: are parenteral narcotics passé and do inhalational agents still have a place in labour?
Topics: Administration, Inhalation; Analgesia, Obstetrical; Female; Humans; Infusions, Parenteral; Meperidin | 1998 |
ABC of labour care. Relief of pain.
Topics: Adaptation, Psychological; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthetics, Inhalation; Fem | 1999 |
Pharmacology of emergency department pain management and conscious sedation.
Topics: Adrenal Cortex Hormones; Analgesics; Analgesics, Non-Narcotic; Conscious Sedation; Emergency Medicin | 2000 |
Environmental health risk of chronic exposure to nitrous oxide in dental practice.
Topics: Anesthetics, Inhalation; Dental Auxiliaries; Dentists; Environmental Health; Female; Humans; Male; N | 2001 |
[Local anesthesia in dentistry. Additional techniques].
Topics: Anesthesia, Dental; Anesthetics, Inhalation; Anesthetics, Local; Behavior; Behavior Therapy; Dental | 1996 |
Neurobiology of nitrous oxide-induced antinociceptive effects.
Topics: Analgesics; Animals; Humans; Neurons; Nitrous Oxide; Pain | 2002 |
The nature and management of labor pain: executive summary.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Obstetrical; Female; Hu | 2002 |
Signal detection theory measurement of pain: a review and critique.
Topics: Acupuncture Therapy; Age Factors; Diazepam; Discrimination, Psychological; Electric Stimulation; Fem | 1977 |
Paediatric analgesia. Which drug? Which dose?
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics; Anti-Inflammatory Agents; Child; Child, Presc | 1991 |
The changing nature of pain control. Clinical aspects of endorphins and enkephalins.
Topics: Acupuncture Therapy; Amino Acids; Analgesics, Opioid; Animals; Differential Threshold; Electric Stim | 1985 |
Evoked potentials as correlates of pain and pain relief in man.
Topics: Acupuncture Therapy; Analgesics; Brain; Dental Pulp; Evoked Potentials; Fentanyl; Humans; Naloxone; | 1986 |
Advances in anaesthesia.
Topics: Analgesics; Anesthesia; Anesthesia, General; Anesthesia, Intravenous; Body Fluids; Halothane; Humans | 1968 |
Awareness during anesthesia.
Topics: Anesthesia, General; Cognition; Consciousness; Female; Humans; Male; Mastectomy; Memory; Middle Aged | 1968 |
94 trials available for nitrous oxide and Ache
| Article | Year |
|---|---|
Value of Music and Nitrous Oxide for Pain Control during Extracorporeal Shock Wave Lithotripsy (ESWL).
Topics: Analgesics; Fentanyl; Humans; Ketoprofen; Lithiasis; Lithotripsy; Midazolam; Music; Nitrous Oxide; P | 2022 |
Prospective, Single-arm, Split-face Pain Management Evaluation of Nitrous Oxide System During Micro-Focused Ultrasound With Visualization.
Topics: Humans; Nitrous Oxide; Pain; Pain Management; Pain Measurement; Patient Satisfaction; Prospective St | 2022 |
Meperidine Compared With Nitrous Oxide for Intrapartum Pain Relief in Multiparous Patients: A Randomized Controlled Trial.
Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Female; Humans; Infant, Newborn; Meperidine; | 2023 |
Is the equimolar mixture of oxygen and nitrous oxide (EMONO) associated with audiovisuals effective in reducing pain and side effects during peripheral venous access placement in children? Protocol for a single-centre randomised controlled trial from Ital
Topics: Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Humans; Italy; Nitrous Oxi | 2023 |
[Application effects of nitrous oxide and oxygen mixed inhalation technology on analgesia and sedation during debridement and dressing change in children with moderate or severe burns].
Topics: Analgesia; Analgesics; Bandages; Burns; Child; Debridement; Female; Follow-Up Studies; Humans; Male; | 2023 |
Pre-mixed nitrous oxide/oxygen mixture treatment of pain induced by postoperative dressing change for perianal abscess: Study protocol for a randomized, controlled trial.
Topics: Abscess; Bandages; China; Double-Blind Method; Humans; Nitrous Oxide; Oxygen; Pain; Pain Measurement | 2020 |
Nitrous oxide analgesia for external cephalic version: A randomized controlled trial.
Topics: Analgesia; Breech Presentation; Female; Humans; Infant; Nitrous Oxide; Pain; Pregnancy; Treatment Ou | 2021 |
Inhaled nitrous oxide can reduce the pain perception in post Caldwell-Luc operation patients-a randomised trial.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Fem | 2017 |
Nitrous Oxide Compared With Intravenous Sedation for Second-Trimester Abortion: A Randomized Controlled Trial.
Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, | 2018 |
Managing pain and anxiety during transabdominal chorionic villus sampling. A noninferiority randomized trial of nitrous oxide vs local anesthesia.
Topics: Adult; Anesthesia, Local; Chorionic Villi Sampling; Female; Humans; Nitrous Oxide; Pain; Pain Manage | 2019 |
The MEOPAeDent trial protocol-an observational study of the Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) effects in paediatric dentistry.
Topics: Adolescent; Child; Child, Preschool; Female; France; Humans; Male; Nitrous Oxide; Oxygen; Pain; Pedi | 2019 |
Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection.
Topics: Administration, Inhalation; Adult; Androstanols; Double-Blind Method; Female; Humans; Injections; Ma | 2013 |
Pain sensation and injection techniques in maxillary dento-alveolar surgery procedures in children--a comparison between conventional and computerized injection techniques (The Wand).
Topics: Adolescent; Anesthesia, Dental; Anesthetics, Inhalation; Anesthetics, Local; Bicuspid; Child; Consci | 2014 |
A prospective, randomized controlled trial of conscious sedation using propofol combined with inhaled nitrous oxide for dental treatment.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Inh | 2015 |
A randomized controlled trial comparing continuous and as-required nitrous oxide use during screening colonoscopy.
Topics: Administration, Inhalation; Aged; Analgesics, Non-Narcotic; Colonoscopy; Drug Administration Schedul | 2015 |
The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study.
Topics: Adult; Aged; Anesthesia; Dose-Response Relationship, Drug; Female; Gynecologic Surgical Procedures; | 2008 |
Midazolam in conjunction with local anaesthesia is superior to Entonox in providing pain relief during bone marrow aspirate and trephine biopsy.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Combined | 2008 |
Randomized clinical trial of Entonox versus midazolam-fentanyl sedation for colonoscopy.
Topics: Administration, Inhalation; Adult; Aged; Anesthetics, Combined; Attitude of Health Personnel; Colono | 2009 |
The effective time and concentration of nitrous oxide to reduce venipuncture pain in children.
Topics: Adolescent; Anesthetics, Inhalation; Child; Dose-Response Relationship, Drug; Facial Expression; Fem | 2009 |
Determining the technical and clinical factors associated with pain for children undergoing botulinum toxin injections under nitrous oxide and anesthetic cream.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Botulinum Toxins, Type A; Cerebral Palsy; C | 2011 |
Evaluation of analgesic effect of equimolar mixture of oxygen and nitrous oxide inhalation during percutaneous biopsy of focal liver lesions: a double-blind randomized study.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Analgesics; Biopsy, Needle; Double-Blind | 2011 |
Equimolar nitrous oxide/oxygen versus placebo for procedural pain in children: a randomized trial.
Topics: Administration, Inhalation; Adolescent; Anesthesia, Inhalation; Child; Double-Blind Method; Drug Com | 2011 |
Nitrous oxide analgesia during retinopathy screening: a randomised controlled trial.
Topics: Administration, Inhalation; Analgesia; Analgesics, Non-Narcotic; Double-Blind Method; Drug Combinati | 2012 |
Nitrous oxide for analgesia in colonoscopy without sedation.
Topics: Administration, Inhalation; Adult; Analgesia; Anesthetics, Inhalation; Colonic Diseases; Colonoscopy | 2011 |
Nitrous oxide/oxygen compared with fentanyl in reducing pain among adults with isolated extremity trauma: a randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Inhalation; Extremities | 2011 |
A double-blind, randomized controlled trial of the use of a 50:50 mixture of nitrous oxide/oxygen in legal abortions.
Topics: Abortion, Legal; Adult; Analgesics, Non-Narcotic; Anesthesia, Local; Double-Blind Method; Female; Hu | 2012 |
Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain: study protocol for a randomized controlled trial.
Topics: Administration, Inhalation; Analgesics; Bandages; Burns; China; Double-Blind Method; Humans; Nitrous | 2012 |
Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children.
Topics: Adolescent; Anesthetics, Local; Blood Glucose; Blood Specimen Collection; Catheterization, Periphera | 2012 |
A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Inhala | 2012 |
In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine.
Topics: Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; Female; Humans; Injections, | 2002 |
[Tolerance of nitrous oxide-oxygen sedation for painful procedures in emergency pediatrics: report of 600 cases].
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Child; Child, Preschool; Emergency Medicine; Female; | 2002 |
Remifentanil and nitrous oxide reduce changes in cerebral blood flow velocity in the middle cerebral artery caused by pain.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Inhalation; Blood Flow | 2003 |
Entonox as an analgesic agent.
Topics: Analgesics; Double-Blind Method; Drug Administration Schedule; Humans; Nitrous Oxide; Oxygen; Pain | 2003 |
Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Intravenous; A | 2003 |
Effective reduction of anxiety and pain during venous cannulation in children: a comparison of analgesic efficacy conferred by nitrous oxide, EMLA and combination.
Topics: Adolescent; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Local | 2003 |
Injection pain: comparison of three mandibular block techniques and modulation by nitrous oxide:oxygen.
Topics: Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Inhalation; Anesthetics, L | 2003 |
Entonox analgesia for prostatic biopsy.
Topics: Analgesia; Anesthetics, Combined; Biopsy; Double-Blind Method; Humans; Male; Nitrous Oxide; Oxygen; | 2003 |
The efficacy of premixed nitrous oxide and oxygen for fiberoptic bronchoscopy in pediatric patients: a randomized, double-blind, controlled study.
Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Bronchoscopy; Child; Child, Preschool | 2004 |
Effectiveness of fixed 50% nitrous oxide oxygen mixture and EMLA cream for insertion of central venous catheters in children.
Topics: Adolescent; Age Distribution; Catheterization, Central Venous; Child; Child, Preschool; Female; Huma | 2004 |
Self-administered nitrous oxide for the management of incident pain in terminally ill patients: a blinded case series.
Topics: Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Cross-Over Studies | 2005 |
Nitrous oxide-oxygen inhalation for outpatient otologic examination and minor procedures performed on the uncooperative child.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Diagnostic Techniques, Otological; Female; Humans; | 2005 |
A combination of lidocaine and nitrous oxide in oxygen is more effective in preventing pain on propofol injection than either treatment alone.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Double-Bli | 2005 |
Effect of nitrous oxide in reducing pain of propofol injection in adult patients.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; F | 2005 |
Prospective, double-blind, randomized trial of equimolar mixture of nitrous oxide/oxygen to prevent pain induced by insertion of venous access ports in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Catheterization, Peripheral; Catheters, In | 2006 |
Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments.
Topics: Adolescent; Analgesics; Anesthetics, Inhalation; Anxiety; Catheterization; Child; Female; Humans; Li | 2005 |
The efficacy of morphine and Entonox analgesia during chest drain removal in children.
Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; Chest Tubes | 2006 |
A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation.
Topics: Administration, Inhalation; Analgesics, Opioid; Anesthetics, Inhalation; Anxiety; Atrial Flutter; Ca | 2006 |
A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination.
Topics: Abortion, Induced; Adolescent; Adult; Anxiety; Double-Blind Method; Female; Humans; Nitrous Oxide; O | 2006 |
A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination.
Topics: Abortion, Induced; Adolescent; Adult; Anxiety; Double-Blind Method; Female; Humans; Nitrous Oxide; O | 2006 |
A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination.
Topics: Abortion, Induced; Adolescent; Adult; Anxiety; Double-Blind Method; Female; Humans; Nitrous Oxide; O | 2006 |
A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination.
Topics: Abortion, Induced; Adolescent; Adult; Anxiety; Double-Blind Method; Female; Humans; Nitrous Oxide; O | 2006 |
Safety of inhalation of a 50% nitrous oxide/oxygen premix: a prospective survey of 35 828 administrations.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Anesthetics, Combined; Anesthetics, Inhalation | 2006 |
A randomized comparison of nitrous oxide plus hematoma block versus ketamine plus midazolam for emergency department forearm fracture reduction in children.
Topics: Adolescent; Analgesics; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Anxiety Agents; Child; Ch | 2006 |
Inhaled nitrous oxide (Entonox) as a short acting sedative during bone marrow examination.
Topics: Administration, Inhalation; Anesthetics, Combined; Anesthetics, Local; Bone Marrow Examination; Drug | 2006 |
Inhaled nitrous oxide during painful procedures: a satisfaction survey.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Catheterization, Peripheral; Child; Child, Preschool; C | 2006 |
The use of hypnosis to improve pain management during voluntary interruption of pregnancy: an open randomized preliminary study.
Topics: Abortion, Induced; Adult; Anxiety; Dilatation and Curettage; Female; Humans; Hypnosis; Nitrous Oxide | 2007 |
[Evaluation of analgesic protocol with nitrous oxide and EMLA cream during botulinum toxin injections in children].
Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Local; Botulinum Toxins, Type A; Cerebral Palsy; | 2007 |
Oral transmucosal fentanyl citrate versus placebo for painful dressing changes: a crossover trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Combined; Ban | 2007 |
Nitrous oxide inhalation to improve patient acceptance and reduce procedure related pain of flexible cystoscopy for men younger than 55 years.
Topics: Adult; Anesthetics, Combined; Cystoscopy; Double-Blind Method; Gels; Humans; Male; Middle Aged; Nitr | 2007 |
Tolerability of an equimolar mix of nitrous oxide and oxygen during painful procedures in very elderly patients.
Topics: Aged, 80 and over; Anesthetics, Inhalation; Female; Humans; Male; Nitrous Oxide; Oxygen; Pain; Pain | 2007 |
Tolerability of an equimolar mix of nitrous oxide and oxygen during painful procedures in very elderly patients.
Topics: Aged, 80 and over; Anesthetics, Inhalation; Female; Humans; Male; Nitrous Oxide; Oxygen; Pain; Pain | 2007 |
Tolerability of an equimolar mix of nitrous oxide and oxygen during painful procedures in very elderly patients.
Topics: Aged, 80 and over; Anesthetics, Inhalation; Female; Humans; Male; Nitrous Oxide; Oxygen; Pain; Pain | 2007 |
Tolerability of an equimolar mix of nitrous oxide and oxygen during painful procedures in very elderly patients.
Topics: Aged, 80 and over; Anesthetics, Inhalation; Female; Humans; Male; Nitrous Oxide; Oxygen; Pain; Pain | 2007 |
Lignocaine is a better analgesic than either ethyl chloride or nitrous oxide for peripheral intravenous cannulation.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anesthetics, Loca | 2007 |
The analgesic effect of inhalational Entonox for extracorporeal shock wave lithotripsy.
Topics: Adult; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Combined; Female; Humans; Lithotrips | 2007 |
Improving the patient's experience of a bone marrow biopsy - an RCT.
Topics: Analysis of Variance; Anesthetics, Inhalation; Bone Marrow Examination; Double-Blind Method; Female; | 2008 |
Entonox as a sedative for bone marrow aspiration and biopsy.
Topics: Analgesics; Anesthesia, Inhalation; Anesthesia, Intravenous; Biopsy, Needle; Bone Marrow Examination | 2008 |
Nitrous oxide-oxygen mixture during care of bedsores and painful ulcers in the elderly: a randomized, crossover, open-label pilot study.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Cross-Over Studies; Drug Therapy, Combination; Female; | 2008 |
EMLA cream and nitrous oxide to alleviate pain induced by palivizumab (Synagis) intramuscular injections in infants and young children.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani | 2008 |
The influence of carbon dioxide and nitrous oxide on pain during laparoscopy: a double-blind, controlled trial.
Topics: Adult; Age Factors; Aged; Ascites; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Fe | 1982 |
Patient-controlled inhalational analgesia in prehospital care: a study of side-effects and feasibility.
Topics: Analgesia; Clinical Trials as Topic; Drug Combinations; Emergencies; Humans; Nitrous Oxide; Oxygen; | 1983 |
Comparison of CO2- and N2O-induced discomfort during peritoneoscopy under local anesthesia.
Topics: Adult; Aged; Anesthesia, Local; Carbon Dioxide; Double-Blind Method; Female; Humans; Laparoscopy; Ma | 1982 |
Antagonism of nitrous oxide analgesia by naloxone in man.
Topics: Analgesia; Arm Injuries; Drug Antagonism; Humans; Ischemia; Male; Naloxone; Nitrous Oxide; Pain; Tou | 1980 |
Desflurane analgesia for vaginal delivery.
Topics: Acid-Base Equilibrium; Adaptation, Physiological; Adult; Analgesia, Obstetrical; Anesthetics, Inhala | 1995 |
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans | 1994 |
Isoflurane in labour.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Drug Combinations; Female; | 1993 |
A comparison of EMLA cream versus nitrous oxide for pediatric venous cannulation.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Anxiety; Catheterization, Per | 1995 |
[EMLA cream in hematology].
Topics: Adolescent; Adult; Anesthesia, General; Anesthetics; Anesthetics, Local; Child; Child, Preschool; Dr | 1995 |
Patient-controlled analgesia with nitrous oxide in cancer pain.
Topics: Analgesia, Patient-Controlled; Humans; Neoplasms; Nitrous Oxide; Pain; Treatment Outcome | 1996 |
Analgesia for venepuncture in a paediatric surgery centre.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthetics, Local; Chi | 1995 |
The effect of nitrous oxide and carbon dioxide pneumoperitoneum on operative and postoperative pain during laparoscopic sterilization under local anesthesia.
Topics: Administration, Oral; Adult; Alfentanil; Analgesia; Analgesics, Opioid; Anesthesia, Local; Anestheti | 1994 |
Subhypnotic propofol does not treat postoperative vomiting in children after adenotonsillectomy.
Topics: Adenoidectomy; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Antiemetics; C | 1997 |
[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination].
Topics: Adjuvants, Anesthesia; Administration, Rectal; Anesthesia, Local; Anesthetics, Inhalation; Anestheti | 1998 |
Modified double burst stimulation of varying stimulating currents.
Topics: Adult; Analysis of Variance; Anesthesia Recovery Period; Anesthetics, Inhalation; Electric Stimulati | 1998 |
Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain.
Topics: Adult; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Cross-Over Studies; Female; Humans; Male; | 1998 |
A randomized clinical trial of continuous-flow nitrous oxide and midazolam for sedation of young children during laceration repair.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Child; Child, Preschool; Conscious Sedation; Emergen | 2001 |
[Analgesia with oxygen-nitrous oxide mixture during percutaneous renal biopsy in children].
Topics: Administration, Inhalation; Age Factors; Analgesia; Anesthetics, Combined; Biopsy, Needle; Chemistry | 2001 |
Inhaled nitrous oxide versus placebo as an analgesic and anxiolytic adjunct to peripheral intravenous cannulation.
Topics: Administration, Inhalation; Adolescent; Adult; Anesthetics, Inhalation; Anxiety; Catheterization, Pe | 2001 |
Venous cannulation and topical ethyl chloride in patients receiving nitrous oxide.
Topics: Administration, Cutaneous; Adolescent; Adult; Aerosols; Aged; Analysis of Variance; Anesthetics, Inh | 1999 |
[Prevention of pain on injection with propofol in children: comparison of nitrous oxide with lidocaine].
Topics: Analgesics; Child; Humans; Hypnotics and Sedatives; Injections; Lidocaine; Nitrous Oxide; Pain; Pain | 2002 |
Comparison of anileridine and pethidine in preventing pain responses during nitrous oxide-oxygen anaesthesia.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Carbon Dioxi | 1975 |
A double-blind trial of patient-controlled nitrous-oxide/oxygen analgesia in myocardial infarction.
Topics: Adult; Aged; Air; Analgesia; Clinical Trials as Topic; Community Participation; Coronary Care Units; | 1975 |
Nitrous oxide as an analgesic in acute myocardial infarction.
Topics: Acute Disease; Blood Pressure; Clinical Trials as Topic; Drug Tolerance; History, Medieval; Humans; | 1976 |
Recovery profile after desflurane-nitrous oxide versus isoflurane-nitrous oxide in outpatients.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Inhalation; Cognition | 1991 |
An evaluation of combining thiopentone and etomidate for the induction of anaesthesia.
Topics: Adult; Anesthesia; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Bloo | 1990 |
Effects of three anaesthesia methods on haemodynamic responses connected with the use of thigh tourniquet in orthopaedic patients.
Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Spinal; Blood Pressure; Bupivacaine; C | 1985 |
Etomidate versus thiopental for induction of anesthesia.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Inhalation; Anesthes | 1985 |
Apparent improvement in postoperative lung volumes by using the Entonox apparatus. A preliminary report.
Topics: Adult; Anesthesia, Inhalation; Female; Herniorrhaphy; Humans; Male; Middle Aged; Morphine; Nitrous O | 1973 |
Comparison between nitrous oxide and methoxyflurane for obstetrical analgesia.
Topics: Adult; Anesthesia, Obstetrical; Apgar Score; Clinical Trials as Topic; Female; Humans; Labor, Obstet | 1971 |
Post-operative pain relief: comparison of methadone and morphine when used concurrently with nitrous-oxide analgesia.
Topics: Humans; Methadone; Morphine; Nitrous Oxide; Pain; Postoperative Care | 1966 |
211 other studies available for nitrous oxide and Ache
| Article | Year |
|---|---|
Procedural analgesia with nitrous oxide at home for epidermolysis bullosa: A case report.
Topics: Adult; Analgesia; Anesthetics, Inhalation; Blister; Epidermolysis Bullosa; Epidermolysis Bullosa Dys | 2022 |
Prevention and treatment of pediatric pain and anxiety caused by botulinum neurotoxin A injections: Inadmissible without nitrous oxide analgesia and sedation?
Topics: Analgesia; Anxiety; Botulinum Toxins, Type A; Child; Conscious Sedation; Humans; Nitrous Oxide; Pain | 2022 |
Nitrous oxide and hypnotherapy in paediatric dentistry.
Topics: Anxiety; Child; Female; Humans; Hypnosis; Male; Nitrous Oxide; Pain; Pediatric Dentistry | 2023 |
Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel.
Topics: Animals; Anti-Inflammatory Agents; Dopamine; Endocannabinoids; Epoxy Compounds; Female; Humans; Inte | 2021 |
Nitrous Oxide/Oxygen Effect on IANB Injection Pain and Mandibular Pulpal Anesthesia in Asymptomatic Subjects.
Topics: Anesthesia, Dental; Anesthetics, Local; Humans; Mandibular Nerve; Nerve Block; Nitrous Oxide; Oxygen | 2021 |
Frequency and duration of ambulance officer exposure to nitrous oxide and methoxyflurane in New Zealand.
Topics: Air Pollutants, Occupational; Ambulances; Anesthetics, Inhalation; Health Personnel; Humans; Inhalat | 2021 |
Patient satisfaction with procedural sedation in the emergency department.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Female | 2017 |
Successful use of nitrous oxide during lumbar punctures: A call for nitrous oxide in pediatric oncology clinics.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Follow-Up Studies; Hum | 2017 |
Nitrous oxide for procedural analgesia at home in a child with epidermolysis bullosa.
Topics: Administration, Inhalation; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Blister; Child, | 2017 |
Nitrous gas analgesia and sedation for lumbar punctures in children: Has the time for practice change come?
Topics: Analgesia; Child; Humans; Neoplasms; Nitrous Oxide; Pain; Spinal Puncture | 2017 |
[MEOPA use practices in a university hospital: Which conformity?]
Topics: Analgesics; Cross-Sectional Studies; France; Guideline Adherence; Health Care Surveys; Health Person | 2017 |
Strategies to decrease injection site pain in botulinum toxin therapy.
Topics: Adult; Anesthetics, Local; Botulinum Toxins, Type A; Female; Humans; Male; Middle Aged; Nitrous Oxid | 2017 |
Nitrous Oxide 70% for Procedural Analgosedation in a Pediatric Emergency Department-With or Without Intranasal Fentanyl?
Topics: Administration, Intranasal; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Drug Therapy, Combi | 2019 |
Use of Local Anesthesia for Pediatric Dental Patients.
Topics: Adolescent; Anesthesia, Dental; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Local; Anes | 2017 |
Comment on: "Successful use of nitrous oxide during lumbar punctures: A call for nitrous oxide in pediatric oncology clinics".
Topics: Child; Humans; Neoplasms; Nitrous Oxide; Pain; Spinal Puncture | 2018 |
Reply to: Comment on: Successful use of nitrous oxide during lumbar punctures: A call for nitrous oxide in pediatric oncology clinics.
Topics: Child; Humans; Neoplasms; Nitrous Oxide; Pain; Spinal Puncture | 2018 |
Feasibility and clinical outcomes of ureteral stenting in the office procedural suite.
Topics: Adult; Aged; Ambulatory Care; Anesthetics, Inhalation; Anesthetics, Local; Feasibility Studies; Fema | 2018 |
Efficacy, pain, and overall patient satisfaction with pediatric upper arm fracture reduction in the emergency department.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Inhalation; Attitude of Health Personnel; Child; Child, | 2019 |
Psychiatric manifestation and pancytopenia during a sickle cell vaso-occlusive crisis: An unusual etiology.
Topics: Adolescent; Anemia, Sickle Cell; Anesthetics, Inhalation; Arterial Occlusive Diseases; Female; Gait | 2019 |
Anesthesia for a child with Camurati-Engelmann disease.
Topics: Anesthesia, General; Anesthetics, Inhalation; Camurati-Engelmann Syndrome; Child; Colonoscopy; Human | 2013 |
[Vitamin B12 deficiency due to nitrous oxide use: unrecognized cause of combined spinal cord degeneration].
Topics: Analgesics, Non-Narcotic; Anemia, Sickle Cell; Drug-Related Side Effects and Adverse Reactions; Huma | 2014 |
[Renal denervation for resistant hypertension without general anesthesia: advantage of a MEOPA morphine protocol. Preliminary experience].
Topics: Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Catheter Ablation; Denervation; Drug Combination | 2013 |
Entonox(R) for the relief of pain or anxiety during IUS/IUD fitting.
Topics: Anesthetics, Combined; Conscious Sedation; Intrauterine Devices; Nitrous Oxide; Oxygen; Pain | 2014 |
κ-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Isoflurane; Lumbar Vertebrae; Methyl Eth | 2014 |
How French paediatric emergency departments manage painful vaso-occlusive episodes in sickle cell disease patients.
Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Emergency Service, Hospital; France; Guideline A | 2014 |
High times, fair maidens, and sweet air: romantic interludes in the life of Dr. Crawford Long.
Topics: Anesthesiology; Anesthetics, Inhalation; England; Ether; History, 19th Century; Love; Nitrous Oxide; | 2014 |
Botulinum toxin therapy for hyperhidrosis: reduction of injection site pain by nitrous oxide/oxygen mixtures.
Topics: Adult; Analgesics; Axilla; Botulinum Toxins; Dermatologic Agents; Female; Hand; Humans; Hyperhidrosi | 2015 |
Pain reduction in patients after applying a nitrous oxide/oxygen mixture (Livopan) during photodynamic therapy: study protocol for an observational study (Livopan study).
Topics: Analgesics; Drug Combinations; Humans; Keratosis, Actinic; Nitrous Oxide; Oxygen; Pain; Pain Measure | 2015 |
Nitrous oxide/oxygen inhalation provides effective analgesia during the administration of tumescent local anaesthesia for endovenous laser ablation.
Topics: Administration, Inhalation; Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Local; Female; Humans | 2015 |
PHEDRE trial protocol - observational study of the prevalence of problematic use of Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) and analgesics in the French sickle-cell disease population.
Topics: Adolescent; Adult; Analgesics; Anemia, Sickle Cell; Child; Female; France; Humans; Male; Nitrous Oxi | 2015 |
F. A. Sweetland's "Liquid Nitrous Oxide" Trade Card.
Topics: Advertising; Anesthetics, Inhalation; History, 19th Century; Humans; Illinois; Nitrous Oxide; Pain; | 2015 |
Painful progress.
Topics: Anesthesia; Animals; Aspirin; Brain; Cocaine; Complex Regional Pain Syndromes; Dental Caries; Electr | 2016 |
Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: The FAN observational study.
Topics: Adolescent; Analgesia; Anesthetics, Inhalation; Anxiety; Australia; Canada; Child; Child, Preschool; | 2017 |
[Value of nitrous oxide-oxygen mixture (Entonox) in transrectal prostate biopsies].
Topics: Administration, Inhalation; Administration, Rectal; Aged; Anxiety; Biopsy; Gels; Humans; Lidocaine; | 2008 |
Nitrous oxide-oxygen analgesia; indications for use and technic of induction.
Topics: Analgesia; Humans; Mouth; Nitrous Oxide; Oxygen; Pain; Pain Management | 1947 |
The mechanism of nitrous oxide analgesia.
Topics: Analgesia; Humans; Nitrous Oxide; Pain; Pain Management | 1948 |
Limited analgesic efficacy of nitrous oxide for painful procedures in children.
Topics: Adolescent; Analgesics, Non-Narcotic; Attitude of Health Personnel; Child; Child, Preschool; Conscio | 2008 |
[Pain prevention with fixed 50% nitrous oxide-oxygen mixture during bone-marrow biopsy].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Biopsy, Needle; Bone Marrow; B | 2009 |
Deletion of mu-opioid receptor in mice does not affect the minimum alveolar concentration of volatile anaesthetics and nitrous oxide-induced analgesia.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Dr | 2009 |
A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Functional Laterality; Male; Naltrexone; Narcotic Antag | 2010 |
Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children.
Topics: Administration, Cutaneous; Administration, Inhalation; Adolescent; Anesthetics; Anti-Dyskinesia Agen | 2009 |
Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; | 2010 |
Nitrous oxide analgesia.
Topics: Analgesia; Humans; Nitrous Oxide; Pain; Pain Management | 1947 |
[Management of the pain of bedsores in the elderly].
Topics: Aged; Analgesics; France; Humans; Nitrous Oxide; Oxygen Inhalation Therapy; Pain; Pain Measurement; | 2010 |
Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway.
Topics: Adrenochrome; Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; | 2011 |
Use of fixed 50% nitrous oxide-oxygen mixture for lumbar punctures in pediatric patients.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug Combinations; Fe | 2011 |
Nitrous oxide by itself is insufficient to relieve pain due to castration in piglets.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Male; Nitrous Oxide; Orchiectomy; Pain; Swine | 2011 |
Conscious sedation or general anaesthetic for intramuscular botulinum toxin injections in children - a two centre cross-sectional prospective audit.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Female; Humans; Lidocaine; Male; Nitrous Oxide; Pain; Para | 2012 |
Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blotting, Western; | 2012 |
Does anesthetic technique influence cancer?
Topics: Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Spinal; Female; Humans; I | 2012 |
Conscious sedation or general anaesthetic for intramuscular botulinum toxin injections in children - a two centre cross-sectional prospective audit.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Female; Humans; Lidocaine; Male; Nitrous Oxide; Pain; Para | 2013 |
Evidence for the involvement of spinal cord alpha1 adrenoceptors in nitrous oxide-induced antinociceptive effects in Fischer rats.
Topics: Analgesics, Non-Narcotic; Animals; Atmosphere Exposure Chambers; Male; Nitrous Oxide; Pain; Proto-On | 2002 |
Future trends in prehospital pain management.
Topics: Acupressure; Analgesics; Emergency Medical Technicians; Emergency Treatment; Forecasting; Humans; Ni | 2003 |
The face of pain: how to assess & manage patient pain in the field.
Topics: Analgesics; Education, Continuing; Emergency Medical Technicians; Emergency Treatment; Humans; Infan | 2003 |
[Better prevention of procedural pain].
Topics: Analgesia; Anesthetics, Inhalation; Diagnostic Techniques and Procedures; Drug Storage; Humans; Nitr | 2003 |
Using Entonox in the community.
Topics: Anesthetics, Combined; Bandages; Community Health Nursing; Drug Storage; Humans; Nitrous Oxide; Oxyg | 2001 |
Pure nitrous oxide at labour; an experimental and clinical investigation of the blood gases in conjunction with intermittent administration of pure nitrous oxide as pain relieving agent during delivery labour.
Topics: Blood; Blood Gas Analysis; Female; Humans; Labor, Obstetric; Nitrous Oxide; Pain; Pregnancy | 1952 |
[Tocographic studies on pain in labor in nitrous oxide and trichloroethylene anesthesia].
Topics: Anesthesia; Anesthesia, Inhalation; Female; Humans; Labor, Obstetric; Nitrous Oxide; Pain; Pregnancy | 1953 |
The effect of nisentil hydrochloride and lorfan tartrate on respiration during nitrous oxide-oxygen anesthesia.
Topics: Alphaprodine; Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Levallorphan; Morphine De | 1956 |
Intramuscular lignocaine; an adjuvant to nitrous oxide-oxygen anaesthesia.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Humans; Lidocaine; Nitrous Oxide; Oxygen; Pain; Pai | 1957 |
Infrared analysis for the estimation of carbon dioxide in the presence of nitrous oxide.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesiology; Carbon Dioxide; Humans; Lidocaine; | 1957 |
Levallorphan and meperidine in anesthesia; study of effects in supplementation of nitrous oxide-oxygenthiopental sodium anesthesia.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Inhalation; Levallorphan; Meperidine; M | 1958 |
Meperidine-levallorphan in anesthesia; study of usefulness of such mixtures in supplementation of nitrous oxide-oxygen-thiopental anesthesia.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Inhalation; Anesthesiology; Levallorpha | 1958 |
[Analgesic anesthesia with nitrous oxide in operations of short duration].
Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Humans; Nitrous Oxide; Pain; Pain Manag | 1961 |
[Results of intravenous barbiturate with N2O anesthesia].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Intravenous; Barbiturates; Nitrous Oxid | 1961 |
EFFICACY OF EDUCATION FOR CHILDBIRTH.
Topics: Aging; Anxiety; Blood Pressure; Education; Female; Humans; Hypnotics and Sedatives; Labor, Obstetric | 1963 |
ANAESTHESIA AND ANALGESIA IN DOMICILIARY MIDWIFERY.
Topics: Analgesia; Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Inhalation; Anesthes | 1964 |
RELIEF OF POST-OPERATIVE PAIN: COMPARISON OF A 25 PER CENT NITROUS-OXIDE AND OXYGEN MIXTURE WITH MORPHINE.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Humans; Morphine; Nitrous Oxide; Oxygen; Oxygen | 1964 |
VALUE OF PREMIXED NITROUS-OXIDE-AND-OXYGEN MIXTURES IN THE RELIEF OF POST-OPERATIVE PAIN. DOUBLE-BLIND TRIAL OF 25 PERCENT NITROUS OXIDE IN OXYGEN, 15 PERCENT NITROUS OXIDE IN OXYGEN, AND OXYGEN.
Topics: Analgesia; Biomedical Research; Double-Blind Method; Humans; Nitrous Oxide; Oxygen; Oxygen Inhalatio | 1964 |
THE PROTECTIVE EFFECT OF THIOPENTONE AGAINST MUSCULAR PAIN AND STIFFNESS WHICH FOLLOWS THE USE OF SUXAMETHONIUM CHLORIDE.
Topics: Adolescent; Analgesia; Biomedical Research; Child; Geriatrics; Humans; Nitrous Oxide; Pain; Pain Man | 1964 |
THERAPEUTIC INHALATION ANAESTHESIA. NEW APPLICATION OF MODERN ANAESTHESIA.
Topics: Analgesia; Anesthesia, Inhalation; Coronary Disease; Humans; Narcotherapy; Nitrous Oxide; Oxygen; Pa | 1964 |
THE USE OF NITROUS OXIDE AND OXYGEN MIXTURES IN THE RELIEF OF POST OPERATIVE PAIN.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesiology; Drug Therapy; Humans; Nitrous Oxide; Oxygen; Pai | 1964 |
[Individual sensitivity to pain and the effects of nitrogen oxide analgesia].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Dentistry, Operative; Nitric Oxide; Nitrous Oxide; | 1955 |
Nitrous oxide analgesia in relation to mental performance.
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Mental Processes; Nitrous Oxide; Pain; Pain Managem | 1960 |
The nature and management of labor pain: part II. Pharmacologic pain relief.
Topics: Analgesia, Epidural; Anesthesia, Obstetrical; Decision Making; Female; Humans; Labor, Obstetric; Nit | 2003 |
Nitrous oxide suppresses tonic and phasic nociceptive behaviors but not formalin-induced c-Fos expression in the rat spinal cord dorsal horn.
Topics: Anesthetics, Inhalation; Animals; Formaldehyde; Halothane; Immunohistochemistry; Nitrous Oxide; Pain | 2003 |
Use of Entonox in the community for control of procedural pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Combined; Bandages; Contraindica | 2003 |
Nitrous oxide hypalgesia in man; pain threshold determinations of the tooth with special reference to the role of oxygen lack and oxygen excess, arterial oxygen saturation, concentration of blood gases and application to operative dentistry.
Topics: Analgesia; Blood Gas Analysis; Dentistry, Operative; Humans; Nitrous Oxide; Oxygen; Pain; Pain Manag | 1951 |
[Nitrogenoxydul; oxygen analgesia in the dental practice].
Topics: Analgesia; Dentistry, Operative; Nitrous Oxide; Oxygen; Pain; Pain Management | 1951 |
Nitrous oxide-oxygen analgesia in major surgery.
Topics: Analgesia; Humans; Nitrous Oxide; Oxygen; Pain; Pain Management | 1952 |
[Indication of nitrous oxide-oxygen analgesia and its limitation with respect to local anesthesia].
Topics: Analgesia; Anesthesia, Local; Humans; Nitrous Oxide; Oxygen; Pain; Pain Management | 1951 |
[Pain sedation with MEOPA].
Topics: Conscious Sedation; Drug Combinations; Humans; Nitrous Oxide; Oxygen Compounds; Pain | 2004 |
Nitrous oxide sedation reduces discomfort caused by atrial defibrillation shocks.
Topics: Administration, Inhalation; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Atrial Fibrillation | 2004 |
Incident pain.
Topics: Activities of Daily Living; Analgesics, Non-Narcotic; Humans; Neoplasms; Nitrous Oxide; Pain; Pain M | 2005 |
[3/6 Use of equimolar mix of oxygen and nitrogen monoxide (Meopa)].
Topics: Administration, Inhalation; Child; Drug Combinations; Humans; Nitrous Oxide; Nurse's Role; Oxygen Co | 2005 |
Simplifying prehospital analgesia. Why certain medications should or should not be used for pain management in the field.
Topics: Analgesics; Anesthetics, Combined; Butorphanol; Emergency Medical Services; Emergency Medical Techni | 2005 |
Painful procedures in children with cancer: comparison of moderate sedation and general anesthesia for lumbar puncture and bone marrow aspiration.
Topics: Analgesics, Non-Narcotic; Anesthesia, General; Bone Marrow Examination; Child; Child, Preschool; Con | 2005 |
A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber.
Topics: Action Potentials; Anesthesia; Anesthetics, Inhalation; Animals; Atmosphere Exposure Chambers; Atmos | 2007 |
Corresponding minimum alveolar concentrations of isoflurane and isoflurane/nitrous oxide have divergent effects on thalamic nociceptive signalling.
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Animals; Drug Synergism; Hot Temperature; Isoflurane | 2007 |
Pupil dilation response to noxious stimulation: effect of varying nitrous oxide concentration.
Topics: Adult; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Combinations; Electric Stimu | 2007 |
Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats.
Topics: Analgesics, Opioid; Animals; Anxiety; Atmosphere Exposure Chambers; Behavior, Animal; Disease Models | 2007 |
[Protocol for management of acute pain in the emergency room].
Topics: Acute Disease; Adult; Clinical Protocols; Drug Combinations; Drug Monitoring; Emergency Nursing; Eme | 2007 |
Health aspects among personnel working with nitrous oxide for procedural pain management in children.
Topics: Air Pollution, Indoor; Anesthetics, Inhalation; Child; Diffusion; Environmental Monitoring; Hemoglob | 2008 |
[Pain in children].
Topics: Age Factors; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anesthetics, Local; Child; Child, Pr | 2008 |
Dopamine D2-like receptor in the nucleus accumbens is involved in the antinociceptive effect of nitrous oxide.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Antagonists; Formaldehyde; M | 2008 |
Pelvic pneumography in the diagnosis of polycystic disease of the ovary, including Stein-Leventhal syndrome. A comparison with the normal pelvic pneumogram.
Topics: Adolescent; Adult; Cysts; Dysmenorrhea; Female; Hirsutism; Humans; Infertility, Female; Menstruation | 1967 |
Techniques of inhalational analgesia in the postoperative period.
Topics: Anesthesia, Inhalation; Humans; Nitrous Oxide; Pain; Postoperative Care; Postoperative Complications | 1967 |
Possible mechanisms of action of nitrous oxide at the opioid receptor.
Topics: Animals; Humans; Nitrous Oxide; Pain; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity R | 1984 |
Megaloblastic haemopoiesis after multiple short-term exposure to nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acute Disease; Adult; Anemia, Macrocytic; | 1982 |
The effects of small doses of barbiturate on the activity of primate nociceptive tract cells.
Topics: Anesthesia, General; Animals; Cerebral Decortication; Decerebrate State; Halothane; Nerve Fibers; Ni | 1984 |
Cognitive modification of pain: information in combination with N2O.
Topics: Adult; Analysis of Variance; Cognition; Dental Pulp; Electric Stimulation; Female; Humans; Nitrous O | 1984 |
[Principles of preclinical pain treatment of emergency patients].
Topics: Analgesics; Anesthesia, Inhalation; Anesthesia, Local; Emergencies; First Aid; Humans; Ketamine; Mep | 1984 |
[Experiences with nitrous oxide analgesia in emergency care].
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Arousal; Child; Child, Preschool; Drug Therapy, Com | 1984 |
Analgesic effects of nitrous oxide with controlled painful stimuli.
Topics: Adolescent; Adult; Anesthesia, Dental; Dental Pulp; Electric Stimulation; Female; Humans; Nitrous Ox | 1983 |
Nitrous oxide analgesia: a psychophysical evaluation using verbal descriptor scaling.
Topics: Anesthesia, Dental; Dental Pulp; Dental Pulp Test; Double-Blind Method; Electric Stimulation; Female | 1984 |
Nitrous oxide analgesia and children's perception of pain.
Topics: Anesthesia, Dental; Child; Child, Preschool; Dental Restoration, Permanent; Double-Blind Method; Hum | 1984 |
Effects of nitrous oxide, transcutaneous electrical stimulation, and their combination on brain potentials elicited by painful stimulation.
Topics: Adult; Anesthesia, Inhalation; Brain; Electric Stimulation; Electric Stimulation Therapy; Electroenc | 1983 |
Management of acute and postoperative pain.
Topics: Acute Disease; Anesthetics, Local; Cryosurgery; Electric Stimulation Therapy; Humans; Injections; Na | 1983 |
Therapeutic nitrous oxide analgesia.
Topics: Humans; Nitrous Oxide; Pain; Postoperative Care | 1983 |
Effect of naloxone on N2O analgesia.
Topics: Humans; Naloxone; Nitrous Oxide; Pain; Sensory Thresholds | 1983 |
Cognitive reversal of expected nitrous oxide analgesia for acute pain.
Topics: Adult; Analgesics; Cognition; Dental Pulp; Electric Stimulation; Humans; Nitrous Oxide; Pain; Sensor | 1983 |
Effects of nitrous oxide exposure on Met-enkephalin levels in discrete areas of rat brain.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Methionine; Male; Nitrous Oxide; Pain; Radioimmuno | 1984 |
History of anesthesia in Lebanon 1800-1914.
Topics: Anesthesia; Anesthesia, Local; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthesiology; Anesthet | 1982 |
Pain control in dentistry.
Topics: Analgesics; Anesthesia, Dental; Humans; Nitrous Oxide; Pain | 1980 |
[Conscious sedation in dentistry].
Topics: Anesthesia, Dental; Anesthesia, Intravenous; Humans; Nitrous Oxide; Pain | 1980 |
[Psychosomatic pain control with laughing gas analgesia (I). Psychological prevention necessary].
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anxiety; Humans; Nitrous Oxide; Pain | 1982 |
[Psychosomatic pain control with laughing gas analgesia (II). Action - indications - contraindications].
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Humans; Nitrous Oxide; Pain | 1982 |
[Psychosomatic pain control in laughing gas analgesia (III)].
Topics: Analgesia; Anesthesia, Dental; Audioanalgesia; Humans; Nitrous Oxide; Pain | 1982 |
Effect of nitrous oxide concentration on event-related potentials during painful tooth stimulation.
Topics: Adult; Analgesics; Dental Pulp; Electric Stimulation; Evoked Potentials; Humans; Male; Nitrous Oxide | 1982 |
Pre-hospital analgesia with Entonox.
Topics: Adolescent; Adult; Aged; Ambulances; Analgesia; Child; Child, Preschool; Drug Combinations; Emergenc | 1982 |
Nitrous oxide analgesia and altitude.
Topics: Adult; Altitude; Anesthesia, Inhalation; Female; Humans; Male; Nitrous Oxide; Pain; Sensory Threshol | 1982 |
[Reaction to pain and wakefulness in anesthesia for cesarean section].
Topics: Anesthesia, Obstetrical; Cesarean Section; Female; Humans; Methoxyflurane; Nitrous Oxide; Pain; Prea | 1982 |
The effects of high-dose fentanyl on cerebral circulation and metabolism in rats.
Topics: Animals; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electroencephalograph | 1982 |
Prehospital administration of nitrous oxide for control of pain.
Topics: Adolescent; Adult; Aged; Analgesics; Female; Humans; Male; Middle Aged; Nitrous Oxide; Pain; Preoper | 1981 |
The similarity of the action of nitrous oxide and morphine.
Topics: Humans; Morphine; Nitrous Oxide; Pain | 1981 |
The effects of naloxone on the analgesic activities of general anaesthetics.
Topics: Analgesia; Anesthetics; Animals; Ethanol; Female; Halothane; Mice; Naloxone; Nitrous Oxide; Nocicept | 1981 |
Nitrous oxide for painful procedures.
Topics: Adult; Analgesia; Child; Humans; Nitrous Oxide; Pain | 1981 |
Methodology for studying cerebral evoked potentials challenged.
Topics: Analgesia; Brain; Evoked Potentials; Humans; Nitrous Oxide; Pain; Tooth | 1980 |
Nitrous oxide at higher elevations.
Topics: Adolescent; Adult; Aged; Altitude; Analgesia; Anesthesia, Local; Child; Child, Preschool; Emergency | 1980 |
Nitrous oxide and oxygen in coronary artery disease.
Topics: Hemodynamics; Humans; Myocardial Infarction; Nitrous Oxide; Oxygen; Pain | 1981 |
Eye pain after outpatient anesthesia.
Topics: Ambulatory Surgical Procedures; Anesthesia, Inhalation; Bandages; Child; Cicatrix; Eye; Halothane; H | 1995 |
Adequacy of general anesthesia for cesarean section.
Topics: Adolescent; Adult; Anesthesia, General; Anesthesia, Obstetrical; Awareness; Cesarean Section; Female | 1993 |
Alterations in pain threshold and psychomotor response associated with subanaesthetic concentrations of inhalation anaesthetics in humans.
Topics: Adult; Anesthesia, Inhalation; Anesthetics; Enflurane; Ethers; Halothane; Humans; Isoflurane; Male; | 1993 |
Nitrous oxide and morphine in children with sickle cell crisis.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Child | 1996 |
Remembrance of times past: the significance of c-fos in pain.
Topics: Analgesia; Analgesics; Anesthetics, Inhalation; Animals; Biomarkers; Fentanyl; Humans; Nervous Syste | 1996 |
Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Cell Count; Fentanyl; | 1996 |
Entonox: too useful to be limited to childbirth?
Topics: Adult; Anesthetics; Drug Combinations; Drug Utilization; Female; Humans; Nitrous Oxide; Nurse Midwiv | 1995 |
[Pain in lumbar puncture. Results of a 2-year discussion at the French Society of Pediatric Oncology].
Topics: Anesthetics, Local; Child; Drug Combinations; Humans; Hypnotics and Sedatives; Lidocaine; Lidocaine, | 1996 |
Nitrous oxide antinociception in BXD recombinant inbred mouse strains and identification of quantitative trait loci.
Topics: Animals; Chromosomes; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Inbred | 1996 |
Adequate general anaesthesia--what are we trying to achieve?
Topics: Anesthetics, Inhalation; Animals; Nitrous Oxide; Pain; Rats; Spinal Cord | 1996 |
In vivo imaging of nitrous oxide-induced changes in cerebral activation during noxious heat stimuli.
Topics: Administration, Inhalation; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Brain; Cerebrovascu | 1997 |
Inhalation anesthetics suppress the expression of c-Fos protein evoked by noxious somatic stimulation in the deeper layer of the spinal cord in the rat.
Topics: Analgesia; Anesthetics, Inhalation; Animals; Formaldehyde; Halothane; Hindlimb; Male; Naloxone; Narc | 1997 |
[Management of anxious and painful manifestations in pediatric uroradiology].
Topics: Administration, Rectal; Age Factors; Anesthetics, Inhalation; Anti-Anxiety Agents; Anxiety; Child; C | 1997 |
[When play banishes the pain].
Topics: Anesthetics, Inhalation; Child; Humans; Nitrous Oxide; Pain; Patient Education as Topic; Play Therap | 1997 |
Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses.
Topics: Animals; Chlorofluorocarbons; Cyclobutanes; Desflurane; Dose-Response Relationship, Drug; Fluorocarb | 1998 |
Response to nitrous-oxide and oxygen among dental phobic patients.
Topics: Adult; Anesthetics, Inhalation; Appointments and Schedules; Attitude to Health; Conscious Sedation; | 1998 |
Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Male; Mice; Mice, Transgenic; Nitrous Ox | 1999 |
The day surgery was changed forever.
Topics: Anesthesia, Inhalation; Boston; Ether; General Surgery; History, 19th Century; Hospitals, Municipal; | 1997 |
[Analgesia using a (50/50) mixture of nitrous oxide/oxygen in children].
Topics: Analgesia; Analgesics; Anesthetics, Inhalation; Child; Humans; Hypoxia; Nitrous Oxide; Oxygen; Pain; | 1999 |
Relative effectiveness of lignocaine-prilocaine emulsion and nitrous oxide inhalation for routine preoperative laboratory testing.
Topics: Adult; Age Factors; Analysis of Variance; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetic | 1999 |
[Clinical observation and nursing of nitrous oxide inhalation to ease delivery pain].
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Drug Monitoring; Female; Humans; Nitrous Oxide | 1997 |
[Utilization of an equimolar mixture of oxygen-nitrous oxide in a general pediatric ward].
Topics: Adolescent; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Female; Humans | 1999 |
Strain differences in the antinociceptive effect of nitrous oxide on the tail flick test in rats.
Topics: Analgesics, Non-Narcotic; Animals; Male; Nitrous Oxide; Pain; Pain Measurement; Rats; Rats, Inbred B | 2000 |
Fixed 50% nitrous oxide oxygen mixture for painful procedures: A French survey.
Topics: Administration, Inhalation; Adolescent; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Child; Ch | 2000 |
Nitrous oxide lacks the antinociceptive effect on the tail flick test in newborn rats.
Topics: Aging; Analgesics, Non-Narcotic; Animals; Animals, Newborn; Female; Male; Nitrous Oxide; Pain; Pain | 2000 |
Nitrous oxide analgesia--a 'sting in the tail'.
Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Humans; Nitrous Oxide; Pain; Rats; Receptors, N-Methyl | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
Effectiveness of local anesthesia in pediatric dental practice.
Topics: Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Local; Child; Child, Pre | 2000 |
[The use of a mixture of an equimolecular mixture of oxygen protoxide of nitrogen in pediatrics].
Topics: Analgesics, Non-Narcotic; Anti-Anxiety Agents; Child; Child, Preschool; Humans; Infant; Nitrous Oxid | 2000 |
Substantial surveillance bias in an unblinded study of pain and adverse effects associated with nitrous oxide inhalation or standard medication for colonoscopy.
Topics: Administration, Inhalation; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Intravenous; | 2001 |
Enkephalin release and opioid receptor activation does not mediate the antinociceptive or sedative/hypnotic effects of nitrous oxide.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalins; Genotype; Hypnotics and Sedative | 2001 |
Does nitrous oxide really induce c-Fos expression related to its analgesic effect?
Topics: Anesthetics, Inhalation; Animals; Gene Expression Regulation; Genes, fos; Neurons; Nitrous Oxide; Pa | 2002 |
Why did Humphry Davy and associates not pursue the pain-alleviating effects of nitrous oxide?
Topics: Analgesics, Non-Narcotic; Anesthesia; History, 18th Century; History, 19th Century; Humans; Nitrous | 2002 |
Nitrous oxide analgesia during intra-articular injection for juvenile idiopathic arthritis.
Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Arthritis, Juvenile; Child; Female; H | 2002 |
Nitrous oxide is not beneficial for breakthrough cancer pain.
Topics: Adult; Analgesics, Non-Narcotic; Female; Humans; Male; Middle Aged; Neoplasms; Nitrous Oxide; Pain; | 2002 |
First at the scene: the relief of pain at an accident. Entonox has proved to be a valuable and relatively safe analgesic.
Topics: Accidents; Adult; Burns; Emergency Medical Technicians; Humans; Male; Nitrous Oxide; Oxygen; Pain; R | 1979 |
The control of apprehension and pain for the child and young adult.
Topics: Adolescent; Anesthesia, Dental; Anxiety; Behavior Therapy; Child; Humans; Nitrous Oxide; Pain | 1977 |
[Use of phentanyl with droperidol or seduxen in nitrous oxide anesthesia in patients with blood vessel diseases of the lower extremities accompanied by pain syndrome].
Topics: Adult; Anesthesia, Inhalation; Diazepam; Droperidol; Fentanyl; Humans; Middle Aged; Nitrous Oxide; P | 1979 |
[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities].
Topics: Adult; Aged; Anesthesia, Endotracheal; Diazepam; Droperidol; Drug Therapy, Combination; Fentanyl; Hu | 1979 |
Nitrous oxide effects on cerebral evoked potential to pain: partial reversal with a narcotic antagonist.
Topics: Adult; Anesthesia, Inhalation; Brain; Dental Pulp; Electric Stimulation; Electroencephalography; Evo | 1979 |
Entonox in the emergency department.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Combinations; Emergency Service, Hospital; Hu | 1979 |
Self-administered analgesia with nitrous oxide. Adjunctive aid for emergency medical care systems.
Topics: Adolescent; Adult; Aged; Analgesics; Child; Child, Preschool; Drug Combinations; Emergency Medical S | 1979 |
Self-administered nitrous oxide: an adjunct analgesic.
Topics: Abscess; Adolescent; Adult; Aged; Analgesics; Drainage; Emergency Service, Hospital; Female; Humans; | 1979 |
[Clinical and experimental results with acupuncture-analgesia (author's transl)].
Topics: Acupuncture Therapy; Adult; Aged; Analgesia; Anesthesia, General; Austria; Cerebellar Cortex; Electr | 1976 |
Letter: Nitrous oxide in myocardial infarction.
Topics: Hemodynamics; Humans; Myocardial Infarction; Nitrous Oxide; Pain | 1976 |
Physiological responses under dental sedation and anaesthesia.
Topics: Analgesia; Anesthesia, Dental; Anxiety; Atropine; Blood Pressure; Diazepam; Epinephrine; Heart Rate; | 1976 |
Somatosensory evoked potentials and analgesia in man.
Topics: Adolescent; Adult; Analgesia; Electric Stimulation; Electroencephalography; Evoked Potentials; Femal | 1975 |
Acupuncture compared with 33 per cent nitrous oxide for dental analgesia: A sensory decision theory evaluation.
Topics: Acupuncture Therapy; Adult; Anesthesia, Dental; Anesthesia, Inhalation; Attitude; Dental Pulp; Diffe | 1975 |
[Treatment of pain syndrome in obliterating diseases of the limbs by subcutaneous injection of nitrous oxide].
Topics: Endarteritis; Humans; Injections, Subcutaneous; Leg; Male; Middle Aged; Nitrous Oxide; Pain; Syndrom | 1975 |
[Autosyringe for extrapulmonary administration of gases].
Topics: Analgesia; Female; Humans; Middle Aged; Nitrous Oxide; Pain; Syringes | 1975 |
Pain during continuous nitrous oxide administration.
Topics: Analgesia; Drug Tolerance; Humans; Male; Nitrous Oxide; Pain; Physical Stimulation | 1976 |
The King Edward Memorial Hospital 1,000 mother survey of methods of pain relief in labour.
Topics: Administration, Inhalation; Analgesia, Epidural; Analgesia, Obstetrical; Attitude; Bupivacaine; Fema | 1991 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; | 1991 |
Dental hygiene licensure specifications on pain control procedures.
Topics: Anesthesia, General; Anesthesia, Local; Anesthesiology; Dental Hygienists; Humans; Licensure; Nitrou | 1990 |
[Control of pain and anxiety in pedodontics].
Topics: Anesthesia, Dental; Anxiety; Child; Child, Preschool; Diazepam; Humans; Hydroxyzine; Ketamine; Nitro | 1989 |
Atmospheric concentrations of nitrous oxide in ambulances during Entonox administration.
Topics: Air Pollutants; Ambulances; Analgesia; Australia; Automobile Driving; Drug Combinations; Emergency M | 1989 |
Pain control in dentistry: oral premedication and nitrous oxide.
Topics: Administration, Oral; Anesthesia, Dental; Anesthesia, Inhalation; Anti-Anxiety Agents; Anxiety; Huma | 1985 |
Analgesics in the management of acute pain.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dru | 1986 |
Prehospital pain control: nitrous oxide inhalation.
Topics: Administration, Inhalation; Emergency Medical Services; Humans; Nitrous Oxide; Pain; Pilot Projects | 1989 |
Maternal arterial oxygen saturation during labor and delivery: pain-dependent alterations and effects on the newborn.
Topics: Acid-Base Equilibrium; Anesthesia, Epidural; Anesthesia, Obstetrical; Delivery, Obstetric; Female; H | 1987 |
Pain management in the child.
Topics: Administration, Topical; Anesthetics, Local; Child; Child, Preschool; Cocaine; Drug Combinations; Em | 1987 |
Cortical acetylcholine efflux with hypercapnia and nociceptive stimulation.
Topics: Acetylcholine; Anesthesia, General; Animals; Cerebral Cortex; Cholinergic Fibers; Decerebrate State; | 1985 |
Nitrous oxide sedation/analgesia in emergency medicine.
Topics: Analgesia; Anxiety; Emergencies; Emergency Medicine; Environmental Pollution; Female; Fetal Diseases | 1985 |
Laparoscopic tubal clip sterilization under local anesthesia.
Topics: Adult; Anesthesia, Local; Diazepam; Drug Evaluation; Fallopian Tubes; Female; Fentanyl; Humans; Lapa | 1974 |
Diazepam compared to thiopentone as induction agent for caesarean sections.
Topics: Amnesia; Anesthesia, Intravenous; Anesthesia, Obstetrical; Apgar Score; Atropine; Cesarean Section; | 1974 |
Analgesia and anaesthesia in labour.
Topics: Analgesia; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Obstetrical; Cesarean Section; Fem | 1974 |
Nitrous oxide-oxygen psychosedation. Council on Dental Therapeutics.
Topics: American Dental Association; Analgesia; Anesthesia, Dental; Anesthesia, Inhalation; Dental Equipment | 1972 |
Emergencies and complications from sedation modalities.
Topics: Analgesics; Anesthesia, Dental; Anxiety; Barbiturates; Dental Care; Drug Interactions; Drug-Related | 1973 |
Use of sedation-analgesia in general dentistry.
Topics: Analgesia; Anesthesia, Dental; Diazepam; Humans; Meperidine; Nitrous Oxide; Pain; Pentobarbital; Sco | 1973 |
Analgesic strength of 33 percent nitrous oxide: a signal detection theory evaluation.
Topics: Adult; Analgesics; Anesthesia, Inhalation; Dose-Response Relationship, Drug; Evaluation Studies as T | 1973 |
A comparison of electrocautery and cryocautery for the treatment of cervical erosions and chronic cervicitis.
Topics: Cryosurgery; Electrocoagulation; Female; Hemorrhage; Humans; Nitrous Oxide; Outpatient Clinics, Hosp | 1973 |
Patient's views on general anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Attitude; Cognition; Diazepam; | 1973 |
A method of study.
Topics: Absorption; Acid-Base Equilibrium; Adult; Anesthesia; Anesthesia, Conduction; Anesthesia, Inhalation | 1969 |
[Therapy of coronary insufficiency with carbochromen].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Blood Circulation; Blood Pressure; Chronic Disease; Cor | 1970 |
Peak osmotic water displacement induced by gases in tissue.
Topics: Anesthesia, Inhalation; Anesthetics; Atmospheric Pressure; Diffusion; Diving; Gases; Humans; Inert G | 1972 |
[The effect of oxide-oxygen analgesia on external respiratory function in the postoperative period].
Topics: Abdomen; Analgesia; Humans; Nitrous Oxide; Pain; Postoperative Complications; Respiratory Insufficie | 1971 |
Control of pain and apprehension.
Topics: Analgesia; Anesthesia, Dental; Anxiety; Humans; Nitrous Oxide; Pain | 1969 |
Semantic confusion and differentiation between general anesthesia and relative analgesia. Indications for and recognition of the analgesic stage.
Topics: Analgesia; Anesthesia, Dental; Anesthesia, Inhalation; Anxiety; Humans; Nitrous Oxide; Oxygen; Pain | 1969 |
[Pain and anesthesiology].
Topics: Anesthesia; Anesthesiology; Ethyl Ethers; Europe; General Surgery; History, 18th Century; History, 1 | 1969 |
The use of nitrous oxide as a freezing agent in cryosurgery of the prostate.
Topics: Adenoma; Carcinoma; Catheterization; Cryosurgery; Freezing; Humans; Male; Methods; Nitrous Oxide; Pa | 1970 |
A comparison of neuroleptanesthesia and halothane in neurosurgery.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta | 1970 |
Inhalation anaesthesia and analgesia.
Topics: Abnormalities, Drug-Induced; Analgesia; Anesthesia, Inhalation; Anesthesia, Obstetrical; Anesthesiol | 1967 |