nitrophenols has been researched along with Laryngeal-Neoplasms* in 3 studies
3 other study(ies) available for nitrophenols and Laryngeal-Neoplasms
| Article | Year |
|---|---|
Humoral immunostimulation. I. Increased uptake of (125I)iododeoxyuridine and (3H)thymidine into TNP-cells treated with anti-TNP antibody.
Interaction of microgram quantities of highly purified rabbit anti-TNP antibodies with TNP-substituted HeLa, HEp-2, and L cells caused an intense stimulation of radioactive nucleoside ([(125)I]UdR and [(3)H]TdR) uptake which was maximal 24-72 h after exposure of cells to antibody. The stimulation of nucleoside uptake and presumaly DNA synthesis was shown to be immuno logically mediated because unsubstituted cells were not stimulated by anti-TNP antibody, normal rabbit gamma globulin did not stimulate TNP-cells, and a hapten inhibitor, epsilon-DNP-lysine, prevented the stimulation of TNP-cells by anti-TNP antibody. These findings demonstrate that interaction of antibody with cell surface antigen can alter cell membrane transport, and possibly can enhance cell growth. Topics: Animals; Antibodies; Carcinoma; Cell Line; Female; Glucose Oxidase; HeLa Cells; Humans; Idoxuridine; Iodides; Iodine Radioisotopes; Kinetics; L Cells; Laryngeal Neoplasms; Mice; Neoplasms; Nitrophenols; Peroxidases; Thymidine; Tritium; Trypsin | 1974 |
Affinity cytotoxicity of tumor cells with antibody-glucose oxidase conjugates, peroxidase, and arsphenamine.
Topics: Animals; Antibodies; Arsphenamine; Carcinoembryonic Antigen; Carcinoma, Squamous Cell; Cell Line; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Glucose Oxidase; Goats; Haptens; HeLa Cells; Humans; Immunoglobulin G; Laryngeal Neoplasms; Nitrophenols; Peroxidases | 1974 |
Stimulation of cells by antibody.
Tumor cell lines exposed to immunoglobulins specific for cell surface antigens developed increased cellular incorporation of [(125)I]iododeoxyuridine and [(3)H]thymidine (up to 200-fold increases over cells treated with normal rabbit immunoglobulins). Antibody-stimulated cells multiplied more rapidly and lived longer than control cells in tissue culture. These observations were made both with cells substituted with 2,4,6-trinitrophenol and purified antibody against 2,4,6-trinitrophenol, and with several cell lines and their respective whole-cell antibodies. Antibodies that were stimulatory at low concentrations were cytotoxic at high concentrations. These observations may have significance in regard to enhancing effects of antibodies on tumor cell growth in vivo. Topics: Animals; Antibodies, Neoplasm; Carcinoma; Cell Line; Colonic Neoplasms; Cross Reactions; DNA, Neoplasm; Epitopes; Female; HeLa Cells; Humans; Idoxuridine; Iodine Radioisotopes; Laryngeal Neoplasms; Mice; Neoplasms; Nitrophenols; Plasmacytoma; Rabbits; Thymidine; Tritium | 1973 |