nitrophenols and Hookworm-Infections

Six critical tests with disophenol were conducted in July, 1978, in fur seal pups (Callorhinus ursinus) naturally-infected with adult hookworms, Uncinaria lucasi, and infested with various stages of two species of sucking lice, Proechinopthirus fluctus (Ferris) and Antarctophthirus callorhini (Osborn). Disophenol at a dose rate of 12.5 mg/kg was administered subcutaneously to each of six pups. Each pup was contained in an individual cage for 60 h posttreatment at which time pups were exmained at necropsy. Efficacy against hookworms ranged from 2% to 88% and of both species of lice ranged from 26% to 90% for the six pups. Disophenol removed approximately 90% of all adult lice but only slightly more than 60% of all nymphs. The only sign of toxicosis was a probable drug related fluid-like feces for four pups from 12 to 60 h posttreatment.

Topics: Alaska; Animals; Caniformia; Fur Seals; Hookworm Infections; Lice Infestations; Nitrophenols

One controlled and six critical tests were conducted in July, 1977 with northern fur seal pups (Callorhinus ursinus) to determine the efficacies of a single dose of dichlorvos capsules at 29.3 to 32.8 mg/kg, tablets at 10.5 to 11.5 mg/kg, or disophenol at 9.9 mg/kg given subcutaneously against natural infections of adult Uncinaria lucasi. In the controlled test, 20 pups were treated and 10 pups were nontreated. Removal of hookworms in this test was 99% for five pups receiving dichlorvos capsules, 99% for five pups receiving dichlorvos tablets, and 77% for 10 pups receiving disophenol. Also, both formulations of dichlorvos and the formulation of disophenol were highly active against natural infestations of two species of sucking lice (Proechinophthirus fluctus and Antarctopthirus callorhini). In critical tests with four pups treated with dichlorvos capsules at 28.6 to 30.6 mg/kg, removal of hookworms was uniformly 100%. Disophenol at 9.9 mg/kg removed 100% and less than 1% of hookworms in two pups, respectively, in critical tests.

Topics: Alaska; Animals; Caniformia; Dichlorvos; Female; Fur Seals; Hookworm Infections; Lice Infestations; Male; Nitrophenols

Topics: Age Factors; Animals; Body Temperature; Dog Diseases; Dogs; Hookworm Infections; Injections, Subcutaneous; Leukocyte Count; Nitrophenols; Pedigree; Respiration; Weaning

Topics: Animals; Anthelmintics; Hookworm Infections; Nitrophenols; Poultry; Poultry Diseases; Research; Strongyloidea; Trachea

Topics: Ancylostomatoidea; Animals; Anthelmintics; Dog Diseases; Dogs; Hookworm Infections; Nitrophenols