nitrophenols and Fever

Acute disophenol toxicosis, induced in 10 dogs by giving 33, 35, or 40 mg of disophenol/kg of body weight, was treated with the antipyretic dipyrone, lactated Ringer's infusions, or ice baths. Rectal temperature and estimates of hemoglobin concentration, packed cell volume, and total white blood cell count and differential count were recorded. Higher hemogram values were sometimes observed for dogs dying of the toxicosis. Toxicosis was induced in 5 other dogs which were not treated; 1 of these, given the low dose of disophenol, recovered. Two of 3 dogs (67%) treated with the antipyretic recovered, 0 of 2 (0%) given lactated Ringer's infusion recovered, and 2 of 5 dogs (40%) treated with ice baths recovered. One of the surviving dogs treated with antipyretic was given the low disophenol dose and all the other survivors were given the medium disophenol dosage level.

Topics: Animals; Anthelmintics; Dipyrone; Dog Diseases; Dogs; Female; Fever; Hematocrit; Hyperventilation; Ice; Infusions, Parenteral; Injections, Subcutaneous; Leukocytosis; Lymphopenia; Male; Nitrophenols; Vomiting

Topics: Acidosis; Animals; Anthelmintics; Bicarbonates; Body Temperature; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Ethanol; Female; Fever; Ice; Iodine; Lactates; Nephritis; Nitrophenols; Physical Exertion; Temperature

Topics: Animals; Body Temperature; Fever; Lagomorpha; Nitrophenols; Pharmacology; Pyrogens; Rabbits; Research

Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Body Temperature; Fever; Nitrophenols; Reserpine

Topics: Dinitrophenols; Fever; Hot Temperature; Nitrophenols

Topics: Aminopyrine; Antipyretics; Dinitrophenols; Diphtheria; Fever; Nitrophenols; Vaccination; Vaccines

Topics: Adrenal Cortex Hormones; Body Temperature; Cortisone; Desoxycorticosterone; Dinitrophenols; Fever; Nitrophenols; Temperature