nitrophenols and Communicable-Diseases

nitrophenols has been researched along with Communicable-Diseases* in 2 studies

Other Studies

2 other study(ies) available for nitrophenols and Communicable-Diseases

Article	Year
Immunochemical termination of self-tolerance. Proceedings of the National Academy of Sciences of the United States of America, 2008, Aug-12, Volume: 105, Issue:32 The ability to selectively induce a strong immune response against self-proteins, or increase the immunogenicity of specific epitopes in foreign antigens, would have a significant impact on the production of vaccines for cancer, protein-misfolding diseases, and infectious diseases. Here, we show that site-specific incorporation of an immunogenic unnatural amino acid into a protein of interest produces high-titer antibodies that cross-react with WT protein. Specifically, mutation of a single tyrosine residue (Tyr(86)) of murine tumor necrosis factor-alpha (mTNF-alpha) to p-nitrophenylalanine (pNO(2)Phe) induced a high-titer antibody response in mice, whereas no significant antibody response was observed for a Tyr(86) --> Phe mutant. The antibodies generated against the pNO(2)Phe are highly cross-reactive with native mTNF-alpha and protect mice against lipopolysaccharide (LPS)-induced death. This approach may provide a general method for inducing an antibody response to specific epitopes of self- and foreign antigens that lead to a neutralizing immune response. Topics: Amino Acid Substitution; Animals; Antibody Formation; Communicable Diseases; Endotoxemia; Epitopes; Immunochemistry; Lipopolysaccharides; Male; Metabolic Diseases; Mice; Mutation, Missense; Neoplasms; Nitrophenols; Self Tolerance; Tumor Necrosis Factor-alpha; Vaccines	2008
N(2-CHLOR 4-NITROPHENYL)-5-CHLORSALICYLAMIDE IN TAENIA SAGINATA INFESTATIONS IN CHILDREN. Indian pediatrics, 1964, Volume: 1 Topics: Animals; Anthelmintics; Biomedical Research; Cestode Infections; Child; Communicable Diseases; Drug Therapy; Infant; Nitrophenols; Placebos; Taenia; Taenia saginata; Toxicology	1964

Article

Year

Immunochemical termination of self-tolerance.

Proceedings of the National Academy of Sciences of the United States of America, 2008, Aug-12, Volume: 105, Issue:32

The ability to selectively induce a strong immune response against self-proteins, or increase the immunogenicity of specific epitopes in foreign antigens, would have a significant impact on the production of vaccines for cancer, protein-misfolding diseases, and infectious diseases. Here, we show that site-specific incorporation of an immunogenic unnatural amino acid into a protein of interest produces high-titer antibodies that cross-react with WT protein. Specifically, mutation of a single tyrosine residue (Tyr(86)) of murine tumor necrosis factor-alpha (mTNF-alpha) to p-nitrophenylalanine (pNO(2)Phe) induced a high-titer antibody response in mice, whereas no significant antibody response was observed for a Tyr(86) --> Phe mutant. The antibodies generated against the pNO(2)Phe are highly cross-reactive with native mTNF-alpha and protect mice against lipopolysaccharide (LPS)-induced death. This approach may provide a general method for inducing an antibody response to specific epitopes of self- and foreign antigens that lead to a neutralizing immune response.

Topics: Amino Acid Substitution; Animals; Antibody Formation; Communicable Diseases; Endotoxemia; Epitopes; Immunochemistry; Lipopolysaccharides; Male; Metabolic Diseases; Mice; Mutation, Missense; Neoplasms; Nitrophenols; Self Tolerance; Tumor Necrosis Factor-alpha; Vaccines

2008

N(2-CHLOR 4-NITROPHENYL)-5-CHLORSALICYLAMIDE IN TAENIA SAGINATA INFESTATIONS IN CHILDREN.

Indian pediatrics, 1964, Volume: 1

Topics: Animals; Anthelmintics; Biomedical Research; Cestode Infections; Child; Communicable Diseases; Drug Therapy; Infant; Nitrophenols; Placebos; Taenia; Taenia saginata; Toxicology

1964