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nitroglycerin and Ventricular Fibrillation

nitroglycerin has been researched along with Ventricular Fibrillation in 41 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.

Research Excerpts

ExcerptRelevanceReference
" During cardiac catheterisation, she was found to have a right coronary artery vasospasm, which resolved with intravenous nitroglycerin."7.78Ventricular fibrillation coinciding with phentermine initiation. ( Klima, LD; Norris, LA; Tobbia, P, 2012)
"To estimate whether the administration of a vasodilatator such as nitroglycerin in combination with epinephrine during cardiopulmonary resuscitation would improve resuscitation outcome in an established model of ventricular fibrillation."7.75Nitroglycerin and epinephrine improve coronary perfusion pressure in a porcine model of ventricular fibrillation arrest: a pilot study. ( Dontas, I; Kitsou, V; Kouskouni, E; Papadimitriou, D; Perrea, D; Rokas, G; Serpetinis, I; Stroumpoulis, K; Xanthos, T, 2009)
"The effect of nitroglycerin on vulnerability to ventricular fibrillation was examined in 44 chloralose-anesthetized dogs."7.66Effect of nitroglycerin on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. ( Lown, B; Stockman, MB; Verrier, RL, 1979)
"Sinus tachycardia bigeminy, ventricular rhythm, ventricular tachycardia, and ventricular fibrillation are produced by relatively small intravenous doses of epinephrine in nonanesthetized dogs and in dogs anesthetized with thiamylal sodium."7.65Arrhythmias in dogs associated with epinephrine and thiamylal anesthesia. ( Hamlin, RL; Muir, WW; Werner, LL, 1975)
"The threshold for ventricular fibrillation induced by a 200 msec train of pulses was measured during a control period and during an intravenous infusion of nitroglycerin in 14 nonischemic open chest dogs."7.65Effect of nitroglycerin on ventricular fibrillation threshold of nonischemic myocardium. ( Dashkoff, N; Pitt, B; Roland, JM; Varghese, PJ, 1976)
" However, the optimal combination, and dosage of cardiovascular drugs to minimize side effects, and to improve outcome has yet to be found."5.31Combination drug therapy with vasopressin, adrenaline (epinephrine) and nitroglycerin improves vital organ blood flow in a porcine model of ventricular fibrillation. ( Benditt, D; Iskos, DN; Lindner, KH; Lurie, KG; McKnite, SH; Sugiyama, A; Voelckel, WG; Wenzel, V; Zielinski, TM, 2002)
"The cardioprotective and antithrombotic activity of molsidomine, a novel therapeutic agent for the treatment of coronary heart disease, was investigated in a series of animal models of myocardial ischemia."4.77The activity of molsidomine in experimental models of ischemic cardiac disease. ( Martorana, PA; Nitz, RE, 1985)
" During cardiac catheterisation, she was found to have a right coronary artery vasospasm, which resolved with intravenous nitroglycerin."3.78Ventricular fibrillation coinciding with phentermine initiation. ( Klima, LD; Norris, LA; Tobbia, P, 2012)
"To estimate whether the administration of a vasodilatator such as nitroglycerin in combination with epinephrine during cardiopulmonary resuscitation would improve resuscitation outcome in an established model of ventricular fibrillation."3.75Nitroglycerin and epinephrine improve coronary perfusion pressure in a porcine model of ventricular fibrillation arrest: a pilot study. ( Dontas, I; Kitsou, V; Kouskouni, E; Papadimitriou, D; Perrea, D; Rokas, G; Serpetinis, I; Stroumpoulis, K; Xanthos, T, 2009)
"We investigated the antiarrhythmic effects of intrapericardial nitroglycerin (NTG) during acute myocardial ischemia in the porcine heart."3.72Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart. ( Kumar, K; Nearing, BD; Nguyen, K; Verrier, RL; Waxman, S; Wellenius, GA; Zhao, SX, 2003)
"The effect of nitroglycerin on vulnerability to ventricular fibrillation was examined in 44 chloralose-anesthetized dogs."3.66Effect of nitroglycerin on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. ( Lown, B; Stockman, MB; Verrier, RL, 1979)
" Subsequent angiography revealed normal coronary anatomy with spasm of the right coronary artery that disappeared after ingestion of one sublingual nitroglycerin tablet."3.66Coronary spasm with ventricular fibrillation during thyrotoxicosis: response to attaining euthyroid state. ( Achuff, SC; Genecin, A; Greene, HL; Wei, JY, 1979)
"Sinus tachycardia bigeminy, ventricular rhythm, ventricular tachycardia, and ventricular fibrillation are produced by relatively small intravenous doses of epinephrine in nonanesthetized dogs and in dogs anesthetized with thiamylal sodium."3.65Arrhythmias in dogs associated with epinephrine and thiamylal anesthesia. ( Hamlin, RL; Muir, WW; Werner, LL, 1975)
"The threshold for ventricular fibrillation induced by a 200 msec train of pulses was measured during a control period and during an intravenous infusion of nitroglycerin in 14 nonischemic open chest dogs."3.65Effect of nitroglycerin on ventricular fibrillation threshold of nonischemic myocardium. ( Dashkoff, N; Pitt, B; Roland, JM; Varghese, PJ, 1976)
" However, the optimal combination, and dosage of cardiovascular drugs to minimize side effects, and to improve outcome has yet to be found."1.31Combination drug therapy with vasopressin, adrenaline (epinephrine) and nitroglycerin improves vital organ blood flow in a porcine model of ventricular fibrillation. ( Benditt, D; Iskos, DN; Lindner, KH; Lurie, KG; McKnite, SH; Sugiyama, A; Voelckel, WG; Wenzel, V; Zielinski, TM, 2002)
"Contemporary approaches to the diagnosis and treatment of acute coronary syndromes have revolutionized the role of the nurse in the coronary care unit."1.27Nursing management of the patient with acute myocardial infarction. ( Boone, S; Del Negro, AA, 1986)
"Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities."1.27Protective activity of defibrotide against lethal acute myocardial ischemia in the cat. ( Mantovani, M; Niada, R; Pescador, R; Porta, R; Prino, G, 1986)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199023 (56.10)18.7374
1990's6 (14.63)18.2507
2000's10 (24.39)29.6817
2010's2 (4.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kitsou, V1
Xanthos, T1
Stroumpoulis, K1
Rokas, G1
Papadimitriou, D1
Serpetinis, I1
Dontas, I1
Perrea, D1
Kouskouni, E1
Dettorre, K1
Brywczynski, J1
McKinney, J1
Slovis, C1
Nicholson, DJ1
Passen, EL1
Wann, S1
Molina-Povedano, MA1
Riera-Sagrera, M1
Ferreruela-Serlavós, M1
Fiol-Sala, M1
Tobbia, P1
Norris, LA1
Klima, LD1
Lurie, KG1
Voelckel, WG1
Iskos, DN1
McKnite, SH1
Zielinski, TM1
Sugiyama, A1
Wenzel, V1
Benditt, D1
Lindner, KH1
Seniuk, W1
Mularek-Kubzdela, T1
Grygier, M1
Grajek, S1
Cieśliński, A1
Kumar, K1
Nguyen, K1
Waxman, S1
Nearing, BD1
Wellenius, GA1
Zhao, SX1
Verrier, RL3
Shinlapawittayatorn, K1
Chattipakorn, S1
Sungnoon, R1
Chattipakorn, N1
Fiderer, W1
Grosse, W1
Biscoping, J1
Kowey, PR1
Lown, B2
Berisso, MZ1
Cavallini, A1
Iannetti, M1
Jugdutt, BI1
Becker, LC1
Hutchins, GM1
Bulkley, BH1
Reid, PR1
Kallman, CH1
Pepine, CJ1
Feldman, RL1
Conti, CR1
Santamore, WP1
Bove, AA1
Carey, RA1
Bussmann, WD1
Micke, G1
Hildenbrand, R1
Klepzig, H1
Weston, CF1
Tigg, A1
Griffiths, BE1
Rumoroso, JR1
Inguanzo, R1
Cembellín, JC1
Bodegas, A1
Barrenetxea, JI1
Kariya, N1
Toyoyama, H1
Furuichi, K1
Kubota, H1
Toyoda, Y1
De Maio, VJ1
Stiell, IG1
Wells, GA1
Spaite, DW1
Tillmanns, H1
Muir, WW1
Werner, LL1
Hamlin, RL1
Stockman, MB1
Wei, JY1
Genecin, A1
Greene, HL1
Achuff, SC1
Rentrop, KP1
Blanke, H1
Karsch, KR1
Kreuzer, H1
Dashkoff, N1
Roland, JM1
Varghese, PJ1
Pitt, B1
Kreuzer, J1
von Hodenberg, E1
Jahn, L1
Kübler, W1
Takayanagi, K1
Fujito, T1
Morooka, S1
Takabatake, Y1
Nakamura, Y1
Holmberg, S1
Boone, S1
Del Negro, AA1
Toole, JG1
Kleinhenz, TJ1
Niada, R1
Porta, R1
Pescador, R1
Mantovani, M1
Prino, G1
Quigley, PJ1
Maurer, BJ1
Kuhnen, R1
Nitsch, J1
Lüderitz, B1
Nitz, RE1
Martorana, PA1
Smith, ER2
Kent, KM2
Redwood, DR1
Epstein, SE2
Borer, JS1
Goldstein, RE1
Sommer, A1
Torresani, J1
Heuillet, G1
Jausseran, JM1
Chevalier-Cholat, AM1
McLean, KH1
Wynn, A1

Reviews

5 reviews available for nitroglycerin and Ventricular Fibrillation

ArticleYear
Pre-hospital cardiac arrest associated with coronary artery spasm.
    International journal of cardiology, 1993, Volume: 38, Issue:1

    Topics: Adult; Cardiac Catheterization; Coronary Angiography; Coronary Vasospasm; Echocardiography; Ergonovi

1993
[Non-invasive acute therapy of cardiac infarction].
    Der Internist, 2001, Volume: 42, Issue:5

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Calcium Chann

2001
The activity of molsidomine in experimental models of ischemic cardiac disease.
    American heart journal, 1985, Volume: 109, Issue:3 Pt 2

    Topics: Animals; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Electric Stimulation;

1985
Acute myocardial infarction and muscle salvage: a potential role for pharmacological agents.
    Canadian journal of surgery. Journal canadien de chirurgie, 1974, Volume: 17, Issue:2

    Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Assisted Circulation; Collateral Circulation; Coronar

1974
The early phase of acute myocardial infarction: pharmacologic aspects of therapy.
    Annals of internal medicine, 1973, Volume: 78, Issue:6

    Topics: Animals; Atropine; Bradycardia; Death, Sudden; Dogs; Electrocardiography; Glucocorticoids; Heart Rat

1973

Trials

2 trials available for nitroglycerin and Ventricular Fibrillation

ArticleYear
Captopril in acute myocardial infarction: beneficial effects on infarct size and arrhythmias.
    Clinical cardiology, 1995, Volume: 18, Issue:8

    Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Clinical Enzyme Tests; Creatine Kinase; Double-

1995
[Coronary angina and stimulation of carotid sinus nerves. Long-term results].
    Archives des maladies du coeur et des vaisseaux, 1973, Volume: 66, Issue:10

    Topics: Aged; Angina Pectoris; Angiography; Carotid Sinus; Clinical Trials as Topic; Drug-Related Side Effec

1973

Other Studies

34 other studies available for nitroglycerin and Ventricular Fibrillation

ArticleYear
Nitroglycerin and epinephrine improve coronary perfusion pressure in a porcine model of ventricular fibrillation arrest: a pilot study.
    The Journal of emergency medicine, 2009, Volume: 37, Issue:4

    Topics: Animals; Cardiopulmonary Resuscitation; Drug Therapy, Combination; Epinephrine; Female; Heart Arrest

2009
Not the nitro? Patient goes into prehospital V-fib arrest following nitroglycerin.
    JEMS : a journal of emergency medical services, 2009, Volume: 34, Issue:5

    Topics: Adult; Ambulatory Care; Chest Pain; Electrocardiography; Heart Arrest; Humans; Male; Nitroglycerin;

2009
Computed tomography for coronary anatomy and perfusion-guiding therapy in a patient with an occluded left anterior descending coronary artery.
    The American heart hospital journal, 2009,Winter, Volume: 7, Issue:2

    Topics: Aged; Coronary Angiography; Coronary Circulation; Coronary Occlusion; Coronary Vessels; Humans; Male

2009
[Recurrent cardiac arrest and coronary vasospasm].
    Medicina intensiva, 2011, Volume: 35, Issue:9

    Topics: Cardiopulmonary Resuscitation; Comorbidity; Coronary Vasospasm; Electric Countershock; Epinephrine;

2011
Ventricular fibrillation coinciding with phentermine initiation.
    BMJ case reports, 2012, Oct-12, Volume: 2012

    Topics: Aged; Appetite Depressants; Coronary Vasospasm; Female; Humans; Nitroglycerin; Phentermine; Vasodila

2012
Combination drug therapy with vasopressin, adrenaline (epinephrine) and nitroglycerin improves vital organ blood flow in a porcine model of ventricular fibrillation.
    Resuscitation, 2002, Volume: 54, Issue:2

    Topics: Animals; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Coronary Circulation; Drug Ther

2002
Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study.
    Journal of internal medicine, 2002, Volume: 252, Issue:4

    Topics: Amiodarone; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Car

2002
Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart.
    Journal of the American College of Cardiology, 2003, May-21, Volume: 41, Issue:10

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Dobutamine; Electrocar

2003
Effects of combined sildenafil-nitric oxide donor on defibrillation efficacy.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:10

    Topics: Animals; Electric Countershock; Heart Ventricles; Hemodynamics; Myocardium; Nitric Oxide; Nitroglyce

2007
[Intraoperative coronary artery spasm with cardiac arrest: cardiologic acute intervention].
    Der Anaesthesist, 2008, Volume: 57, Issue:3

    Topics: Anesthesia; Blood Gas Analysis; Coronary Angiography; Coronary Vasospasm; Heart Arrest; Humans; Intr

2008
Decreased vulnerability to ventricular fibrillation by vasodilator-induced baroreceptor sensitisation.
    Cardiovascular research, 1983, Volume: 17, Issue:2

    Topics: Alprostadil; Animals; Denervation; Dogs; Epoprostenol; Female; Male; Nitroglycerin; Norepinephrine;

1983
Sudden death during continuous Holter monitoring out of hospital after nitroglycerin consumption.
    The American journal of cardiology, 1984, Sep-01, Volume: 54, Issue:6

    Topics: Adult; Death, Sudden; Electrocardiography; Humans; Male; Myocardial Infarction; Nitroglycerin; Ventr

1984
Effect of intravenous nitroglycerin on collateral blood flow and infarct size in the conscious dog.
    Circulation, 1981, Volume: 63, Issue:1

    Topics: Animals; Arterial Occlusive Diseases; Collateral Circulation; Coronary Vessels; Dogs; Dose-Response

1981
Action of intracoronary nitroglycerin in refractory coronary artery spasm.
    Circulation, 1982, Volume: 65, Issue:2

    Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Coronary Vasospasm; Coronary Vessels; Ergonovine;

1982
Tachycardia induced reduction in coronary blood flow distal to a stenosis.
    International journal of cardiology, 1982, Volume: 2, Issue:1

    Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Disease; Coronar

1982
Left main coronary artery spasm.
    International journal of cardiology, 1995, Volume: 51, Issue:2

    Topics: Amlodipine; Angina Pectoris; Coronary Vasospasm; Diagnosis, Differential; Follow-Up Studies; Humans;

1995
Coronary artery spasm induced by trigeminal nerve stimulation and vagal reflex during intracranial operation.
    Journal of neurosurgical anesthesiology, 1999, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Autonomic Nervous System; Bradycardia; Coronary Vasospasm; Craniotomy; El

1999
Cardiac arrest witnessed by emergency medical services personnel: descriptive epidemiology, prodromal symptoms, and predictors of survival. OPALS study group.
    Annals of emergency medicine, 2000, Volume: 35, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Ambulances; Cohort Studies; Confidence Intervals; Elect

2000
Arrhythmias in dogs associated with epinephrine and thiamylal anesthesia.
    American journal of veterinary research, 1975, Volume: 36, Issue:9

    Topics: Anesthesia, Intravenous; Animals; Arrhythmias, Cardiac; Blood Pressure; Bundle of His; Cardiac Compl

1975
Effect of nitroglycerin on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion.
    The American journal of cardiology, 1979, Volume: 43, Issue:2

    Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Coronary Disease; Dogs; Drug Therapy, Combinati

1979
Coronary spasm with ventricular fibrillation during thyrotoxicosis: response to attaining euthyroid state.
    The American journal of cardiology, 1979, Volume: 43, Issue:2

    Topics: Coronary Angiography; Coronary Disease; Electrocardiography; Female; Humans; Hyperthyroidism; Middle

1979
Initial experience with transluminal recanalization of the recently occluded infarct-related coronary artery in acute myocardial infarction -- comparison with conventionally treated patients.
    Clinical cardiology, 1979, Volume: 2, Issue:2

    Topics: Adult; Aged; Angioplasty, Balloon; Coronary Angiography; Creatine Kinase; Electrocardiography; Femal

1979
Effect of nitroglycerin on ventricular fibrillation threshold of nonischemic myocardium.
    The American journal of cardiology, 1976, Volume: 38, Issue:2

    Topics: Action Potentials; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Co

1976
[Recurrent ventricular fibrillation in a patient with angiographically normal coronary arteries and intermittent ST segment elevation].
    Zeitschrift fur Kardiologie, 1990, Volume: 79, Issue:8

    Topics: Adult; Angina Pectoris; Angiocardiography; Drug Therapy, Combination; Electrocardiography; Humans; M

1990
Headache angina with fatal outcome.
    Japanese heart journal, 1990, Volume: 31, Issue:4

    Topics: Aged; Angina Pectoris; Electrocardiography, Ambulatory; Female; Headache; Humans; Male; Middle Aged;

1990
Myocardial infarction--coronary care.
    Acta medica Scandinavica. Supplementum, 1986, Volume: 712

    Topics: Adrenergic beta-Antagonists; Animals; Coronary Care Units; Fibrinolytic Agents; Heart Rupture; Human

1986
Nursing management of the patient with acute myocardial infarction.
    Cardiovascular clinics, 1986, Volume: 16, Issue:3

    Topics: Angioplasty, Balloon; Coronary Care Units; Early Ambulation; Emergency Medical Services; Fibrinolyti

1986
Nitroglycerin and potassium.
    The American journal of cardiology, 1986, Apr-15, Volume: 57, Issue:11

    Topics: Humans; Injections; Nitroglycerin; Potassium; Ventricular Fibrillation

1986
Protective activity of defibrotide against lethal acute myocardial ischemia in the cat.
    Thrombosis research, 1986, May-01, Volume: 42, Issue:3

    Topics: Animals; Cats; Coronary Disease; Creatine Kinase; Epoprostenol; Heart Ventricles; Hemodynamics; Male

1986
Ventricular fibrillation during coronary angiography: association with potassium-containing glyceryl trinitrate.
    The American journal of cardiology, 1985, Jul-01, Volume: 56, Issue:1

    Topics: Angina Pectoris; Angiography; Angioplasty, Balloon; Coronary Angiography; Humans; Male; Middle Aged;

1985
[Explosion of transdermal nitroglycerin during defibrillation].
    Deutsche medizinische Wochenschrift (1946), 1985, Jan-04, Volume: 110, Issue:1

    Topics: Aged; Electric Countershock; Electrodes; Explosions; Female; Humans; Myocardial Infarction; Nitrogly

1985
Beneficial electrophysiologic effects of nitroglycerin during acute myocardial infarction.
    The American journal of cardiology, 1974, Volume: 33, Issue:4

    Topics: Animals; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Electric Stimulation; E

1974
Nitroglycerin-induced reduction in the incidence of spontaneous ventricular fibrillation during coronary occlusion in dogs.
    The American journal of cardiology, 1974, Volume: 33, Issue:4

    Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Elect

1974
A coronary care unit: results of the first year of operation.
    The Medical journal of Australia, 1968, Mar-23, Volume: 1, Issue:12

    Topics: Acute Disease; Adult; Aged; Anticoagulants; Arrhythmias, Cardiac; Digitoxin; Electrocardiography; Fe

1968