nitroglycerin has been researched along with Vasospasm, Intracranial in 7 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the rabbit subarachnoid hemorrhage (SAH) model, the sensitivity of spastic basilar arteries to nitric oxide (NO) was enhanced whereas the endothelial function to release/produce NO became impaired, as described previously." | 5.31 | Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. ( Azuma, H; Hirakawa, K; Isotani, E; Ito, Y; Mizuno, Y, 2000) |
| "Patients with cerebral vasospasm caused by aneurysmal subarachnoid hemorrhage (aSAH) are often treated with intra-arterial (IA) vasodilator infusion." | 1.62 | Use of single versus multiple vasodilator agents in the treatment of cerebral vasospasm: is more better than less? ( Bulsara, K; Chen, PR; Day, AL; Erkmen, K; Kim, DH; Lopez-Rivera, V; Oni-Orisan, AO; Sanzgiri, A; Sheriff, FG; Sheth, S; Vahidy, FS, 2021) |
| "Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a major cause of high morbidity and mortality." | 1.37 | Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. ( Fandino, J; Fathi, AR; Graupner, T; Jakob, SM; Marbacher, S; Schroth, G; Wehrli, F, 2011) |
| "In the rabbit subarachnoid hemorrhage (SAH) model, the sensitivity of spastic basilar arteries to nitric oxide (NO) was enhanced whereas the endothelial function to release/produce NO became impaired, as described previously." | 1.31 | Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. ( Azuma, H; Hirakawa, K; Isotani, E; Ito, Y; Mizuno, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, PR | 1 |
| Bulsara, K | 1 |
| Lopez-Rivera, V | 1 |
| Sheriff, FG | 1 |
| Sanzgiri, A | 1 |
| Sheth, S | 1 |
| Oni-Orisan, AO | 1 |
| Vahidy, FS | 1 |
| Erkmen, K | 1 |
| Kim, DH | 1 |
| Day, AL | 1 |
| Fathi, AR | 1 |
| Marbacher, S | 2 |
| Graupner, T | 2 |
| Wehrli, F | 1 |
| Jakob, SM | 2 |
| Schroth, G | 1 |
| Fandino, J | 2 |
| Neuschmelting, V | 1 |
| Pluta, RM | 1 |
| Ito, Y | 1 |
| Isotani, E | 1 |
| Mizuno, Y | 1 |
| Azuma, H | 1 |
| Hirakawa, K | 1 |
| Tanaka, Y | 2 |
| Masuzawa, T | 2 |
| Saito, M | 2 |
| Yamada, T | 2 |
| Ebihara, A | 1 |
| Iwasa, H | 1 |
| Mori, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury[NCT04951453] | 150 participants (Actual) | Observational | 2021-08-18 | Active, not recruiting | |||
| Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage[NCT05686265] | 32 participants (Anticipated) | Observational | 2023-05-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nitroglycerin and Vasospasm, Intracranial
| Article | Year |
|---|---|
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
6 other studies available for nitroglycerin and Vasospasm, Intracranial
| Article | Year |
|---|---|
Use of single versus multiple vasodilator agents in the treatment of cerebral vasospasm: is more better than less?
Topics: Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nicardipine; Nitroglycerin; Retrospect | 2021 |
Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo.
Topics: Animals; Disease Models, Animal; Injections, Spinal; Intracranial Aneurysm; Male; Nitroglycerin; Rab | 2011 |
Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo.
Topics: Animals; Basilar Artery; Cerebral Angiography; Female; Injections, Spinal; Male; Nimodipine; Nitric | 2008 |
Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin.
Topics: Administration, Cutaneous; Animals; Basilar Artery; Coronary Angiography; Hemodynamics; In Vitro Tec | 2000 |
Inhibitory effects of verapamil and nitroglycerin on contraction and cytosolic Ca2+ levels in cerebrovascular smooth muscle during chronic cerebral vasospasm.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chronic Disease; Cytosol; Disease Models, Anima | 2001 |
Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Brain Ischemia; Drug Combinations; Female; Huma | 2001 |