Page last updated: 2024-11-01

nitroglycerin and Thrombosis

nitroglycerin has been researched along with Thrombosis in 29 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.

Research Excerpts

ExcerptRelevanceReference
"Adding NTG to a thrombolytic regimen with rt-PA, aspirin and heparin increases the magnitude of restored flow and total patency duration following recanalization in a rabbit model of arterial thrombosis."7.69Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model. ( Battler, A; Chernine, A; Hasdai, D; Kornowski, R; Ovadia, Z, 1995)
"Nitroglycerin inhibits platelet aggregation in vitro, but its effect on thrombosis and platelet function in vivo is controversial."7.69Nitroglycerin inhibits experimental thrombosis and reocclusion after thrombolysis. ( Davis, JH; Guevara, T; Lucchesi, BR; Rote, WE; Werns, SW, 1994)
" This report documents a therapeutic role for nitroglycerin, a nitric oxide donor, in the treatment of acutely thrombosed external hemorrhoids and anal fissure."3.69Treatment of benign anal disease with topical nitroglycerin. ( Gorfine, SR, 1995)
"Adding NTG to a thrombolytic regimen with rt-PA, aspirin and heparin increases the magnitude of restored flow and total patency duration following recanalization in a rabbit model of arterial thrombosis."3.69Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model. ( Battler, A; Chernine, A; Hasdai, D; Kornowski, R; Ovadia, Z, 1995)
"Nitroglycerin inhibits platelet aggregation in vitro, but its effect on thrombosis and platelet function in vivo is controversial."3.69Nitroglycerin inhibits experimental thrombosis and reocclusion after thrombolysis. ( Davis, JH; Guevara, T; Lucchesi, BR; Rote, WE; Werns, SW, 1994)
"LV thrombosis was found in 427 patients (5."2.69Predischarge two-dimensional echocardiographic evaluation of left ventricular thrombosis after acute myocardial infarction in the GISSI-3 study. ( Chiarella, F; Domenicucci, S; Maggioni, A; Santoro, E; Vecchio, C, 1998)
"We report a case of acute renal infarction due to underlying arterial fibrillation, where a novel interventional therapeutic method was used."1.72A rare cause of abdominal pain managed unconventionally: acute renal infarction caused by atrial fibrillation: a case report. ( Ge, T; Song, EJ; Tang, S; Wang, J; Zhou, W; Zhu, Z, 2022)
"Evidence suggests that children with familial hypercholesterolemia (FH) have endothelial dysfunction."1.35Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia. ( Antoniades, C; Charakida, M; Latsios, G; Pitsavos, C; Siasos, G; Skoumas, I; Stefanadi, E; Stefanadis, C; Tousoulis, D; Vasiliadou, C, 2009)
"Nitroglycerin was infused to produce a 10% decrease in mean arterial pressure in 27 normal pigs by exposing their circulating arterial blood to porcine aortic media in an ex vivo perfusion chamber."1.29Methylene blue inhibits the antithrombotic effect of nitroglycerin. ( Baribeau, J; Johnstone, MT; Lacoste, L; Lam, JY; Théroux, P; Waters, D, 1993)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19909 (31.03)18.7374
1990's12 (41.38)18.2507
2000's4 (13.79)29.6817
2010's2 (6.90)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Ge, T1
Zhu, Z1
Wang, J1
Zhou, W1
Song, EJ1
Tang, S1
Stanisavljevic, N1
Stojanovich, L1
Djokovic, A1
Todic, B1
Dopsaj, V1
Saponjski, J1
Saponjski, D1
Markovic, O1
Belizna, C1
Zdravkovic, M1
Marisavljevic, D1
Charakida, M1
Tousoulis, D1
Skoumas, I1
Pitsavos, C1
Vasiliadou, C1
Stefanadi, E1
Antoniades, C1
Latsios, G1
Siasos, G1
Stefanadis, C1
Chłopicki, S1
Akingbola, O1
Singh, D1
Steiner, R1
Frieberg, E1
Petrescu, M1
Saxonhouse, MA1
ANNONI, G1
FERRARIO, R1
MAGGI, A1
PERLICK, E1
Cherrier, F1
Amor, M1
Godenir, JP1
Neimann, JL1
Cuillière, M1
Houppe, JP1
Gorfine, SR1
Kornowski, R1
Chernine, A1
Hasdai, D1
Ovadia, Z1
Battler, A1
Meng, YY1
Trachtenburg, J1
Ryan, US1
Abendschein, DR1
Westberg, G1
Shultz, PJ1
Raij, L1
Johnstone, MT1
Lam, JY1
Lacoste, L1
Baribeau, J1
Théroux, P1
Waters, D1
Werns, SW1
Rote, WE1
Davis, JH1
Guevara, T1
Lucchesi, BR1
Berrazueta, JR1
Poveda, JJ1
Ochoteco, J1
Amado, JA1
Puebla, F1
Salas, E1
Sarabia, M1
Ottman, EH1
Gall, SA1
Chiarella, F1
Santoro, E1
Domenicucci, S1
Maggioni, A1
Vecchio, C1
Bülow, C1
Harling, H1
Kayanoki, Y1
Kawata, S1
Yamasaki, E1
Kiso, S1
Inoue, S1
Tamura, S1
Taniguchi, N1
Matsuzawa, Y1
Cavcić, J1
Turcić, J1
Martinac, P1
Mestrović, T1
Mladina, R1
Pezerović-Panijan, R1
Taylor, AJ1
Bobik, A1
Berndt, MC1
Ramsay, D1
Jennings, G1
Gorlin, R1
Kay, HB1
Walsh, DB1
Zwolak, RM1
McDaniel, MD1
Schneider, JR1
Cronenwett, JL1
Diederen, W1
Kadatz, R1
Hurwitz, MM1
Perloff, JK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Warfarin After Anterior ST-Elevation Myocardial Infarction[NCT00662467]20 participants (Actual)Interventional2006-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for nitroglycerin and Thrombosis

ArticleYear
[The vascular endothelium and pharmacological therapy of atherothrombosis].
    Kardiologia polska, 2003, Volume: 59 Suppl 2

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atherosclerosis;

2003
Management of neonatal thrombosis.
    Clinics in perinatology, 2012, Volume: 39, Issue:1

    Topics: Diagnosis, Differential; Diagnostic Imaging; Heparin; Humans; Infant, Newborn; Microsurgery; Nitrogl

2012
[CHRONIC COR PULMONALE AS A RESULT OF THROMBOEMBOLIC DISEASES].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1964, Oct-01, Volume: 19

    Topics: Aminophylline; Coumarins; Drug Therapy; Humans; Hypertension; Hypertension, Pulmonary; Lung; Nitrogl

1964
[Unstable angina. Generalities. Innovations].
    Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Angioplasty, Ba

1983
Angina pectoris: getting the most from drug therapy.
    Drugs, 1977, Volume: 13, Issue:4

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Corona

1977

Trials

3 trials available for nitroglycerin and Thrombosis

ArticleYear
The anti-inflammatory and analgesic action of transdermal glyceryltrinitrate in the treatment of infusion-related thrombophlebitis.
    Postgraduate medical journal, 1993, Volume: 69, Issue:807

    Topics: Administration, Cutaneous; Adult; Aged; Cyclic GMP; Double-Blind Method; Female; Forearm; Humans; In

1993
Predischarge two-dimensional echocardiographic evaluation of left ventricular thrombosis after acute myocardial infarction in the GISSI-3 study.
    The American journal of cardiology, 1998, Apr-01, Volume: 81, Issue:7

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Echocardiogra

1998
Comparison of topically applied 0.2% glyceryl trinitrate ointment, incision and excision in the treatment of perianal thrombosis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2001, Volume: 33, Issue:4

    Topics: Administration, Topical; Anesthesia, Local; Follow-Up Studies; Hemorrhoids; Humans; Nitroglycerin; O

2001

Other Studies

21 other studies available for nitroglycerin and Thrombosis

ArticleYear
A rare cause of abdominal pain managed unconventionally: acute renal infarction caused by atrial fibrillation: a case report.
    Journal of medical case reports, 2022, Oct-19, Volume: 16, Issue:1

    Topics: Abdominal Pain; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Diltiazem; Humans;

2022
Asymmetric Dimethylarginine Is a Marker of Endothelial Dysfunction in Thrombotic Antiphospholipid Syndrome Patients.
    International journal of molecular sciences, 2022, Oct-14, Volume: 23, Issue:20

    Topics: Antiphospholipid Syndrome; Arginine; Biomarkers; C-Reactive Protein; Dilatation, Pathologic; Endothe

2022
Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia.
    Atherosclerosis, 2009, Volume: 204, Issue:2

    Topics: Adolescent; Age Factors; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studi

2009
High-dose tissue plasminogen activator, topical nitroglycerin, and heparin for severe ischemic injury in a neonate.
    Clinical pediatrics, 2012, Volume: 51, Issue:11

    Topics: Administration, Cutaneous; Catheterization; Drug Therapy, Combination; Femoral Artery; Fibrinolytic

2012
[USE OF TRINITROGLYCERIN BY VENOUS OR ARTERIAL ROUTE IN ARTERIOPATHIES EXCLUDING CORONARY CIRCULATION].
    Minerva cardioangiologica, 1963, Volume: 11

    Topics: Arteriosclerosis; Cerebral Hemorrhage; Cerebrovascular Disorders; Coronary Circulation; Diabetic Ang

1963
Treatment of benign anal disease with topical nitroglycerin.
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:5

    Topics: Administration, Topical; Adult; Anal Canal; Defecation; Female; Fissure in Ano; Follow-Up Studies; H

1995
Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model.
    European heart journal, 1995, Volume: 16, Issue:2

    Topics: Animals; Aspirin; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Drug Therapy, Combina

1995
Potentiation of endogenous nitric oxide with superoxide dismutase inhibits platelet-mediated thrombosis in injured and stenotic arteries.
    Journal of the American College of Cardiology, 1995, Volume: 25, Issue:1

    Topics: Animals; Arteries; Aspirin; Blood Platelets; Cardiovascular Agents; Constriction, Pathologic; Cyclic

1995
Exogenous nitric oxide prevents endotoxin-induced glomerular thrombosis in rats.
    Kidney international, 1994, Volume: 46, Issue:3

    Topics: Animals; Arginine; Blood Pressure; Kidney Diseases; Kidney Glomerulus; Lipopolysaccharides; Male; NG

1994
Methylene blue inhibits the antithrombotic effect of nitroglycerin.
    Journal of the American College of Cardiology, 1993, Volume: 21, Issue:1

    Topics: Animals; Antifibrinolytic Agents; Aorta; Cyclic GMP; Drug Evaluation, Preclinical; Fibrinolytic Agen

1993
Nitroglycerin inhibits experimental thrombosis and reocclusion after thrombolysis.
    American heart journal, 1994, Volume: 127, Issue:4 Pt 1

    Topics: Animals; Anistreplase; Blood Flow Velocity; Carotid Arteries; Clinical Protocols; Dogs; Male; Nitrog

1994
Myocardial infarction in the third trimester of pregnancy secondary to an aortic valve thrombus.
    Obstetrics and gynecology, 1993, Volume: 81, Issue:5 ( Pt 2)

    Topics: Adult; Aortic Valve; Female; Heart Valve Prosthesis; Heparin; Humans; Myocardial Infarction; Nifedip

1993
[Combined nitroglycerin-heparin infusion in mesenteric venous thrombosis].
    Ugeskrift for laeger, 1998, Jun-08, Volume: 160, Issue:24

    Topics: Adult; Anticoagulants; Drug Combinations; Female; Heparin; Humans; Infusions, Intravenous; Intestine

1998
Reduced nitric oxide production by L-arginine deficiency in lysinuric protein intolerance exacerbates intravascular coagulation.
    Metabolism: clinical and experimental, 1999, Volume: 48, Issue:9

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Antithrombin III; Arginine; Blood Coagulation Disorders

1999
Experimental rupture of atherosclerotic lesions increases distal vascular resistance: a limiting factor to the success of infarct angioplasty.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Volume: 22, Issue:1

    Topics: Adenosine; Animals; Arteriosclerosis; Capillary Permeability; Hindlimb; Iliac Artery; Microcirculati

2002
Principles in selection of therapy.
    Major problems in internal medicine, 1976, Volume: 11

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Antihypertensive Agents; Arrhythmias, Cardiac; Coronar

1976
Intragraft drug infusion as an adjunct to balloon catheter thrombectomy for salvage of thrombosed infragenicular vein grafts: a preliminary report.
    Journal of vascular surgery, 1990, Volume: 11, Issue:6

    Topics: Aged; Blood Vessel Prosthesis; Catheterization; Female; Graft Occlusion, Vascular; Heparin; Humans;

1990
Local oxygen tension and blood flow in the normal and chronic ischemic myocardium in the anesthetized dog.
    Advances in experimental medicine and biology, 1973, Volume: 39

    Topics: Anesthesia, Intravenous; Animals; Chloralose; Collateral Circulation; Constriction; Coronary Circula

1973
When "refractory" angina has an unsuspected cause.
    Geriatrics, 1972, Volume: 27, Issue:8

    Topics: Aged; Angina Pectoris; Angiography; Coronary Disease; Extracorporeal Circulation; Female; Heart Fail

1972
Coronary artery disease. Antidote to a stereotype.
    The American journal of cardiology, 1972, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aneurysm; Angina Pectoris; Aortic Arch Syndromes; Arteries; Arterios

1972
Problems with prosthetic valve surgery.
    Postgraduate medicine, 1971, Volume: 49, Issue:6

    Topics: Adult; Anemia, Hemolytic; Angina Pectoris; Aortic Valve Insufficiency; Aortic Valve Stenosis; Cardia

1971