Page last updated: 2024-11-01

nitroglycerin and Tendinitis

nitroglycerin has been researched along with Tendinitis in 27 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Tendinitis: Inflammation of TENDONS. It is characterized by the degeneration of tendons accompanied by an inflammatory repair response, fibroblastic proliferation, and formation of granulation tissue. Tendinitis is not a clinical diagnosis and can be confirmed only by histopathological findings.

Research Excerpts

ExcerptRelevanceReference
"This study aims to determine the effects of transdermal nitroglycerine on shoulder pain and on functional shoulder movement in patients with spinal cord injuries and shoulder tendinopathies."9.15Transdermal nitroglycerine treatment of shoulder tendinopathies in patients with spinal cord injuries. ( Alcanyis-Alberola, M; García-Massó, X; Giner-Pascual, M; Gonzalez, LM; Querol, F; Salinas-Huertas, S, 2011)
"To compare transdermal nitroglycerin (NTG) and corticosteroid infiltration in patients with rotator cuff tendinitis (RCT)."9.09[Transdermal nitroglycerin versus corticosteroid infiltration for rotator cuff tendinitis]. ( Caballero, J; Gallardo, C; Martínez, T; Pons, S, 2001)
"We have conducted a prospective double blind randomized and placebo controlled clinical study in 20 patients with shoulder pain syndrome caused by supraspinatus tendinitis to determine whether transdermal nitroglycerin (NTG) has analgesic action in this condition."9.08Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. ( Amado, JA; Berrazueta, JR; Losada, A; Ochoteco, A; Poveda, J; Riestra, A; Salas, E, 1996)
"This study aims to determine the effects of transdermal nitroglycerine on shoulder pain and on functional shoulder movement in patients with spinal cord injuries and shoulder tendinopathies."5.15Transdermal nitroglycerine treatment of shoulder tendinopathies in patients with spinal cord injuries. ( Alcanyis-Alberola, M; García-Massó, X; Giner-Pascual, M; Gonzalez, LM; Querol, F; Salinas-Huertas, S, 2011)
"To compare transdermal nitroglycerin (NTG) and corticosteroid infiltration in patients with rotator cuff tendinitis (RCT)."5.09[Transdermal nitroglycerin versus corticosteroid infiltration for rotator cuff tendinitis]. ( Caballero, J; Gallardo, C; Martínez, T; Pons, S, 2001)
"We have conducted a prospective double blind randomized and placebo controlled clinical study in 20 patients with shoulder pain syndrome caused by supraspinatus tendinitis to determine whether transdermal nitroglycerin (NTG) has analgesic action in this condition."5.08Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. ( Amado, JA; Berrazueta, JR; Losada, A; Ochoteco, A; Poveda, J; Riestra, A; Salas, E, 1996)
" Six of these articles concerning different topics (depression, tuberculosis detection, anticoagulation at home, cholinesterase inhibitors, insomnia and therapies, transdermal nitroglycerin and tendinopathies) are presented."4.83[Primary care in general internal medicine: relevant information in 2005]. ( Amstutz, V; Bodenmann, P; Favrat, B; Martin, S; Michaelis-Conus, K; Pasche, O, 2006)
"(2,3) Conservative management options for chronic Achilles tendinopathy include eccentric (lengthening) exercises, extracorporeal shockwave therapy (ESWT), topical nitroglycerin, low level laser therapy, orthoses, splints or injections (e."3.78Management of chronic Achilles tendinopathy. ( , 2012)
"The effects were independent of the dosage used."2.82Effectiveness of topical glyceryl trinitrate in treatment of tendinopathy - systematic review and meta-analysis. ( Johansson, J; Juhola, J; Kemppi, V; Saltychev, M, 2022)
"A prospective, randomized, double-blind, placebo-controlled trial involving a total of sixty-five patients (eighty-four Achilles tendons) was performed to compare continuous application of topical glyceryl trinitrate (at a dosage of 1."2.71Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial. ( Appleyard, RC; Murrell, GA; Nelson, J; Paoloni, JA, 2004)
"The term tendinopathy is preferred to tendinitis because of the presence of a disordered and degenerative healing process-not inflammation-in the pathologic tendon."2.61Management of Chronic Tendon Injuries. ( Kane, SF; Olewinski, LH; Tamminga, KS, 2019)
"Achilles tendinopathy is a painful condition that occurs commonly in both active and inactive individuals."2.45Conservative treatment of Achilles tendinopathy: emerging techniques. ( Ishikawa, SN; Lake, JE, 2009)
"Achilles tendinopathy is generally caused by chronic stress to the tendon, leading to a defective arrangement of collagen fibers in the Achilles tendon."2.44Noninsertional Achilles tendinopathy: pathology and management. ( McCabe, F; McShane, JM; Ostick, B, 2007)
"The ideal treatment for tendinopathy remains unclear."2.44Treatment of tendinopathy: what works, what does not, and what is on the horizon. ( Andres, BM; Murrell, GA, 2008)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.70)18.2507
2000's14 (51.85)29.6817
2010's11 (40.74)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Saltychev, M1
Johansson, J1
Kemppi, V1
Juhola, J1
Challoumas, D1
Kirwan, PD1
Borysov, D1
Clifford, C1
McLean, M1
Millar, NL1
van Rijn, D1
van den Akker-Scheek, I2
Steunebrink, M2
Diercks, RL1
Zwerver, J2
van der Worp, H1
Kane, SF1
Olewinski, LH1
Tamminga, KS1
Papalia, R1
Moro, L1
Franceschi, F1
Albo, E1
D'Adamio, S1
Di Martino, A1
Vadalà, G1
Faldini, C1
Denaro, V1
Nguyen, L1
Kelsberg, G1
Beecher, D1
Safranek, S1
Knobloch, K2
Thermann, H1
Cumpston, M1
Johnston, RV1
Wengier, L1
Buchbinder, R1
Lake, JE1
Ishikawa, SN1
Courville, XF1
Coe, MP1
Hecht, PJ1
Gambito, ED1
Gonzalez-Suarez, CB1
Oquiñena, TI1
Agbayani, RB1
Hüfner, T1
Giner-Pascual, M1
Alcanyis-Alberola, M1
Querol, F1
Salinas-Huertas, S1
García-Massó, X1
Gonzalez, LM1
Orchard, J1
Kountouris, A1
Brandsema, R1
Groenenboom, P1
Weir, A1
Paoloni, JA3
Appleyard, RC2
Nelson, J2
Murrell, GA5
Bodenmann, P1
Pasche, O1
Amstutz, V1
Martin, S1
Michaelis-Conus, K1
Favrat, B1
McShane, JM1
Ostick, B1
McCabe, F1
Kane, TP1
Ismail, M1
Calder, JD1
Glaser, T1
Poddar, S1
Tweed, B1
Webb, CW1
Andres, BM1
Berrazueta, JR1
Losada, A1
Poveda, J1
Ochoteco, A1
Riestra, A1
Salas, E1
Amado, JA1
Pons, S1
Gallardo, C1
Caballero, J1
Martínez, T1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Stromal Vascular Fraction (SVF) and Platelets Rich Plasma (PRP) in Osteoarthritis and Tendinopathy: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study: (SPOT Study).[NCT05660824]Phase 4195 participants (Anticipated)Interventional2023-06-30Not yet recruiting
TENDOSHOCK-2010 - Combined Sclerosing Therapy, Extracorporeal Shockwave Therapy, Eccentric Training and Topical Glyceryl Trinitrate for Athletic Tendinopathies[NCT01185951]Phase 2114 participants (Actual)Interventional2007-01-31Active, not recruiting
Eccentric Training With Our Without Elbow Brace for Epicondylitis - a Randomized Clinical Trial[NCT01273688]Phase 390 participants (Anticipated)Interventional2011-02-28Not yet recruiting
The Use of Topical Glyceryl Trinitrate (GTN) and Eccentric Exercises in the Treatment of Midportion Achilles Tendinopathy: a Randomized Placebo Controlled Trial[NCT02499484]76 participants (Actual)Interventional2016-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

14 reviews available for nitroglycerin and Tendinitis

ArticleYear
Effectiveness of topical glyceryl trinitrate in treatment of tendinopathy - systematic review and meta-analysis.
    Disability and rehabilitation, 2022, Volume: 44, Issue:20

    Topics: Achilles Tendon; Glycerol; Humans; Nitroglycerin; Pain; Tendinopathy; Tennis Elbow

2022
Topical glyceryl trinitrate for the treatment of tendinopathies: a systematic review.
    British journal of sports medicine, 2019, Volume: 53, Issue:4

    Topics: Achilles Tendon; Activities of Daily Living; Administration, Cutaneous; Cumulative Trauma Disorders;

2019
Management of Chronic Tendon Injuries.
    American family physician, 2019, 08-01, Volume: 100, Issue:3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cryotherapy; Exer

2019
Endothelial dysfunction and tendinopathy: how far have we come?
    Musculoskeletal surgery, 2013, Volume: 97, Issue:3

    Topics: Aging; Animals; Apoptosis; Biomarkers; Cumulative Trauma Disorders; Endothelium, Vascular; Enzyme In

2013
Topical glyceryl trinitrate for rotator cuff disease.
    The Cochrane database of systematic reviews, 2009, Jul-08, Issue:3

    Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Humans; Nitroglycerin; Randomize

2009
Conservative treatment of Achilles tendinopathy: emerging techniques.
    Foot and ankle clinics, 2009, Volume: 14, Issue:4

    Topics: Achilles Tendon; Animals; Aprotinin; Electrocoagulation; High-Energy Shock Waves; Humans; Nitroglyce

2009
Current concepts review: noninsertional Achilles tendinopathy.
    Foot & ankle international, 2009, Volume: 30, Issue:11

    Topics: Achilles Tendon; Aprotinin; Exercise Therapy; High-Energy Shock Waves; Humans; Low-Level Light Thera

2009
Evidence on the effectiveness of topical nitroglycerin in the treatment of tendinopathies: a systematic review and meta-analysis.
    Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:8

    Topics: Acute Disease; Administration, Cutaneous; Chronic Disease; Clinical Trials as Topic; Humans; Nitrogl

2010
The management of tennis elbow.
    BMJ (Clinical research ed.), 2011, May-10, Volume: 342

    Topics: Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Botulinum Toxins, Typ

2011
[Primary care in general internal medicine: relevant information in 2005].
    Revue medicale suisse, 2006, Jan-25, Volume: 2, Issue:50

    Topics: Administration, Cutaneous; Administration, Oral; Alzheimer Disease; Anticoagulants; Cholinesterase I

2006
Using nitric oxide to treat tendinopathy.
    British journal of sports medicine, 2007, Volume: 41, Issue:4

    Topics: Achilles Tendon; Administration, Cutaneous; Animals; Free Radical Scavengers; Humans; Nitric Oxide;

2007
Noninsertional Achilles tendinopathy: pathology and management.
    Current sports medicine reports, 2007, Volume: 6, Issue:5

    Topics: Achilles Tendon; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Di

2007
Clinical inquiries. What's the best way to treat Achilles tendonopathy?
    The Journal of family practice, 2008, Volume: 57, Issue:4

    Topics: Achilles Tendon; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Braces; Exercise;

2008
Treatment of tendinopathy: what works, what does not, and what is on the horizon.
    Clinical orthopaedics and related research, 2008, Volume: 466, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Glucocorticoids; Humans; Interce

2008

Trials

9 trials available for nitroglycerin and Tendinitis

ArticleYear
Comparison of the Effect of 5 Different Treatment Options for Managing Patellar Tendinopathy: A Secondary Analysis.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2019, Volume: 29, Issue:3

    Topics: Administration, Cutaneous; Adolescent; Adult; Athletes; Double-Blind Method; Exercise Therapy; Extra

2019
Transdermal nitroglycerine treatment of shoulder tendinopathies in patients with spinal cord injuries.
    Spinal cord, 2011, Volume: 49, Issue:9

    Topics: Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitroglycerin; Placebo Effect; Should

2011
Topical glyceryl trinitrate treatment of chronic patellar tendinopathy: a randomised, double-blind, placebo-controlled clinical trial.
    British journal of sports medicine, 2013, Volume: 47, Issue:1

    Topics: Administration, Cutaneous; Adolescent; Adult; Analgesics; Chronic Pain; Double-Blind Method; Humans;

2013
Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial.
    The Journal of bone and joint surgery. American volume, 2004, Volume: 86, Issue:5

    Topics: Achilles Tendon; Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female;

2004
Topical glyceryl trinitrate application in the treatment of chronic supraspinatus tendinopathy: a randomized, double-blinded, placebo-controlled clinical trial.
    The American journal of sports medicine, 2005, Volume: 33, Issue:6

    Topics: Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female; Humans; Male; Mi

2005
Three-year followup study of topical glyceryl trinitrate treatment of chronic noninsertional Achilles tendinopathy.
    Foot & ankle international, 2007, Volume: 28, Issue:10

    Topics: Achilles Tendon; Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female;

2007
Topical glyceryl trinitrate and noninsertional Achilles tendinopathy: a clinical and cellular investigation.
    The American journal of sports medicine, 2008, Volume: 36, Issue:6

    Topics: Achilles Tendon; Administration, Topical; Adult; Aged; Combined Modality Therapy; Humans; Middle Age

2008
Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study.
    Pain, 1996, Volume: 66, Issue:1

    Topics: Administration, Cutaneous; Adult; Analgesia; Double-Blind Method; Female; Humans; Male; Middle Aged;

1996
[Transdermal nitroglycerin versus corticosteroid infiltration for rotator cuff tendinitis].
    Atencion primaria, 2001, Oct-31, Volume: 28, Issue:7

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections, Intra-Articular; In

2001

Other Studies

4 other studies available for nitroglycerin and Tendinitis

ArticleYear
Clinical inquiries. Are topical nitrates safe and effective for upper extremity tendinopathies?
    The Journal of family practice, 2014, Volume: 63, Issue:8

    Topics: Administration, Topical; Arthralgia; Humans; Nitroglycerin; Tendinopathy; Upper Extremity; Vasodilat

2014
[Achilles tendinopathy--modern evidence-based recommendations].
    MMW Fortschritte der Medizin, 2008, Jun-26, Volume: 150, Issue:26-27

    Topics: Achilles Tendon; Administration, Topical; Bandages; Diagnosis, Differential; Humans; Neovascularizat

2008
[Conservative treatment of Achilles tendinopathy].
    Der Unfallchirurg, 2010, Volume: 113, Issue:9

    Topics: Achilles Tendon; Administration, Topical; Arthralgia; Cryotherapy; Evidence-Based Medicine; Humans;

2010
Management of chronic Achilles tendinopathy.
    Drug and therapeutics bulletin, 2012, Volume: 50, Issue:8

    Topics: Achilles Tendon; Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Analgesics; Blood Transf

2012