nitroglycerin has been researched along with Syndrome in 48 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Guidelines recommend short-acting nitrates, such as sublingual nitroglycerin, for the treatment of acute angina pectoris in patients with chronic coronary syndromes (CCSs), common comorbidities in HF." | 9.51 | Vericiguat in Combination with Short-Acting Nitroglycerin in Patients With Chronic Coronary Syndromes: The Randomized, Phase Ib, VENICE Study. ( Becker, C; Besche, N; Boettcher, M; Donath, F; Düngen, HD; Gurniak, M; Karakas, M; Koch, T; Mikus, G; Thuermann, PA; Werner, N, 2022) |
| "We have conducted a prospective double blind randomized and placebo controlled clinical study in 20 patients with shoulder pain syndrome caused by supraspinatus tendinitis to determine whether transdermal nitroglycerin (NTG) has analgesic action in this condition." | 9.08 | Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. ( Amado, JA; Berrazueta, JR; Losada, A; Ochoteco, A; Poveda, J; Riestra, A; Salas, E, 1996) |
| "Intravenous ephedrine administered during a C-section was observed to cause an acute coronary syndrome in a pregnant woman with normal coronaries." | 7.72 | Acute coronary syndrome induced by intravenous ephedrine in pregnant woman with normal coronaries. ( Chamoun, A; Gedevanishvili, A; Rahman, AM; Uretsky, BF, 2004) |
| "Severe bradycardia associated with profound systemic arterial hypotension was observed in 3 patients following sublingual nitroglycerin administration." | 7.66 | Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration. ( Nemerovski, M; Shah, PK, 1981) |
| "Intravenous trinitroglycerine (IV TNT) was used in 17 patients with myocardial pre-infarction syndrome defined by the presence of prolonged spontaneous attacks of attacks of angina, with electrocardiographic changes, persisting despite medical treatment with beta-blockers and oral nitrite derivatives." | 7.66 | [Intravenous trinitroglycerin in the treatment of pre-infarction syndrome. Preliminary results (author's transl)]. ( Baudet, M; Besse, P; Bourdarias, JP; Ferreira, A; Huret, JF; Page, A; Roudaut, R, 1979) |
| "Nitrates have been used as vasodilators in AHFS for many years and have been shown to improve some aspects of AHFS in some small studies." | 6.49 | Nitrates for acute heart failure syndromes. ( Brooks, SC; Diercks, DB; Fermann, GJ; Kidney, R; McCabe, A; Pospisil, C; Salter, N; Seupaul, RA; Wakai, A, 2013) |
| "Sympathetic crashing acute pulmonary edema (SCAPE) describes the most severe presentation of acute heart failure (AHF)." | 5.62 | High-dose nitroglycerin infusion for the management of sympathetic crashing acute pulmonary edema (SCAPE): A case series. ( Bisanzo, M; Blohm, E; DeWitt, KM; Porter, BA; Sheeser, M; Stemple, K, 2021) |
| " Guidelines recommend short-acting nitrates, such as sublingual nitroglycerin, for the treatment of acute angina pectoris in patients with chronic coronary syndromes (CCSs), common comorbidities in HF." | 5.51 | Vericiguat in Combination with Short-Acting Nitroglycerin in Patients With Chronic Coronary Syndromes: The Randomized, Phase Ib, VENICE Study. ( Becker, C; Besche, N; Boettcher, M; Donath, F; Düngen, HD; Gurniak, M; Karakas, M; Koch, T; Mikus, G; Thuermann, PA; Werner, N, 2022) |
| "To compare the safety and efficacy of nesiritide versus intravenous nitroglycerin (NTG) in patients with acute coronary syndromes enrolled in the Vasodilation in the Management of Acute Congestive heart failure trial." | 5.11 | Nesiritide in congestive heart failure associated with acute coronary syndromes: a pilot study of safety and efficacy. ( Emerman, CL; Peacock, WF; Young, J, 2004) |
| "We have conducted a prospective double blind randomized and placebo controlled clinical study in 20 patients with shoulder pain syndrome caused by supraspinatus tendinitis to determine whether transdermal nitroglycerin (NTG) has analgesic action in this condition." | 5.08 | Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. ( Amado, JA; Berrazueta, JR; Losada, A; Ochoteco, A; Poveda, J; Riestra, A; Salas, E, 1996) |
| "As part of the Women's Ischemia Syndrome Evaluation (WISE) sponsored by the National Heart, Lung, and Blood Institute, 163 women referred for clinically indicated coronary angiography underwent coronary reactivity assessment with quantitative coronary angiography and intracoronary Doppler flow before and after intracoronary administration of acetylcholine, adenosine, and nitroglycerin and were then followed up for clinical outcomes." | 3.72 | Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). ( Arant, CB; Bairey Merz, CN; Handberg, E; Johnson, BD; Kerensky, RA; McGorray, SP; Olson, MB; Pepine, CJ; Sharaf, BL; Smith, KM; Sopko, G; von Mering, GO; Wessel, TR, 2004) |
| "Intravenous ephedrine administered during a C-section was observed to cause an acute coronary syndrome in a pregnant woman with normal coronaries." | 3.72 | Acute coronary syndrome induced by intravenous ephedrine in pregnant woman with normal coronaries. ( Chamoun, A; Gedevanishvili, A; Rahman, AM; Uretsky, BF, 2004) |
| "The aim of this study was to evaluate the effects of hyperventilation (HV) and of ic nitroglycerin (NTG) on coronary diameters and hemodynamics in 32 patients with angina pectoris." | 3.67 | [Abnormal coronary response to vasomotor stimuli: analogies between variant angina and X syndrome]. ( Bugiardini, R; Lenzi, S; Morgagni, GL; Ottani, F; Pozzati, A; Puddu, P, 1989) |
| "Severe bradycardia associated with profound systemic arterial hypotension was observed in 3 patients following sublingual nitroglycerin administration." | 3.66 | Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration. ( Nemerovski, M; Shah, PK, 1981) |
| "Intravenous trinitroglycerine (IV TNT) was used in 17 patients with myocardial pre-infarction syndrome defined by the presence of prolonged spontaneous attacks of attacks of angina, with electrocardiographic changes, persisting despite medical treatment with beta-blockers and oral nitrite derivatives." | 3.66 | [Intravenous trinitroglycerin in the treatment of pre-infarction syndrome. Preliminary results (author's transl)]. ( Baudet, M; Besse, P; Bourdarias, JP; Ferreira, A; Huret, JF; Page, A; Roudaut, R, 1979) |
| " We determined the mean of 2 separate measurements of heparin dosage requirement, antithrombin III activity, and the dose of intravenous nitroglycerin or isosorbide dinitrate at the time that the ratio of activated partial thromboplastin time (aPTT) to baseline aPTT was 1." | 2.68 | Interaction of intravenous heparin and organic nitrates in acute ischemic syndromes. ( Cho, SK; In, HH; Kim, JJ; Kim, SS; Koh, KK; Lee, HJ; Moon, TH; Park, GS; Song, JH, 1995) |
| "Nitrates have been used as vasodilators in AHFS for many years and have been shown to improve some aspects of AHFS in some small studies." | 2.49 | Nitrates for acute heart failure syndromes. ( Brooks, SC; Diercks, DB; Fermann, GJ; Kidney, R; McCabe, A; Pospisil, C; Salter, N; Seupaul, RA; Wakai, A, 2013) |
| "Sympathetic crashing acute pulmonary edema (SCAPE) describes the most severe presentation of acute heart failure (AHF)." | 1.62 | High-dose nitroglycerin infusion for the management of sympathetic crashing acute pulmonary edema (SCAPE): A case series. ( Bisanzo, M; Blohm, E; DeWitt, KM; Porter, BA; Sheeser, M; Stemple, K, 2021) |
| "Non-painful symptoms in migraine following headache resolution can last up to days." | 1.62 | The migraine postdrome: Spontaneous and triggered phenotypes. ( Bose, PR; Goadsby, PJ; Karsan, N; Nagaraj, K; Peréz-Rodríguez, A, 2021) |
| "Kounis syndrome has been known as allergenic angina and/or allergenic myocardial infarction following an allergic reaction." | 1.38 | A case of coronary spasm with resultant acute myocardial infarction: likely the result of an allergic reaction. ( Aydin, MK; Yurtdaş, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (27.08) | 18.7374 |
| 1990's | 3 (6.25) | 18.2507 |
| 2000's | 23 (47.92) | 29.6817 |
| 2010's | 4 (8.33) | 24.3611 |
| 2020's | 5 (10.42) | 2.80 |
| Authors | Studies |
|---|---|
| Boettcher, M | 1 |
| Düngen, HD | 1 |
| Donath, F | 1 |
| Mikus, G | 1 |
| Werner, N | 1 |
| Thuermann, PA | 1 |
| Karakas, M | 1 |
| Besche, N | 1 |
| Koch, T | 1 |
| Gurniak, M | 1 |
| Becker, C | 1 |
| Jc, M | 1 |
| Chopra, A | 1 |
| Js, H | 1 |
| Mahajan, A | 1 |
| Nair, T | 1 |
| Ray, S | 1 |
| Tr, M | 1 |
| Pandey, A | 1 |
| Srivastava, S | 1 |
| Kumar, YS | 1 |
| Navasundi, G | 1 |
| Das, DR | 1 |
| Abhyankar, MV | 1 |
| Revankar, S | 1 |
| Mate, P | 1 |
| Stemple, K | 1 |
| DeWitt, KM | 1 |
| Porter, BA | 1 |
| Sheeser, M | 1 |
| Blohm, E | 1 |
| Bisanzo, M | 1 |
| Huang, SH | 1 |
| Chang, SW | 1 |
| Wang, AY | 1 |
| Karsan, N | 1 |
| Peréz-Rodríguez, A | 1 |
| Nagaraj, K | 1 |
| Bose, PR | 1 |
| Goadsby, PJ | 1 |
| Wakai, A | 1 |
| McCabe, A | 1 |
| Kidney, R | 1 |
| Brooks, SC | 1 |
| Seupaul, RA | 1 |
| Diercks, DB | 1 |
| Salter, N | 1 |
| Fermann, GJ | 1 |
| Pospisil, C | 1 |
| Izzo, D | 1 |
| Brillantino, A | 1 |
| Iacobellis, F | 1 |
| Falco, P | 1 |
| Renzi, A | 1 |
| Rea, R | 1 |
| Sedlak, TL | 1 |
| Johnson, BD | 2 |
| Pepine, CJ | 2 |
| Reis, SE | 1 |
| Bairey Merz, CN | 2 |
| Yurtdaş, M | 1 |
| Aydin, MK | 1 |
| Skelding, KA | 1 |
| Goldstein, JA | 1 |
| Mehta, L | 1 |
| Pica, MC | 1 |
| O'Neill, WW | 1 |
| Honderick, T | 1 |
| Williams, D | 1 |
| Seaberg, D | 1 |
| Wears, R | 1 |
| Vita, JA | 1 |
| Gokce, N | 1 |
| Duffy, SJ | 1 |
| Kahn, D | 1 |
| Tomasian, D | 1 |
| Palmisano, J | 1 |
| Thomas, S | 1 |
| Holbrook, M | 1 |
| Keaney, JF | 1 |
| Suleĭmenova, BA | 1 |
| Kovalev, NN | 1 |
| Totskiĭ, AD | 1 |
| Finsterer, J | 1 |
| Schlager, T | 1 |
| Kopsa, W | 1 |
| Wild, E | 1 |
| Pasquetto, G | 1 |
| Reimers, B | 1 |
| Favero, L | 1 |
| Saccà, S | 1 |
| Cernetti, C | 1 |
| Napodano, M | 1 |
| Piccolo, P | 1 |
| Pascotto, P | 1 |
| von Mering, GO | 1 |
| Arant, CB | 1 |
| Wessel, TR | 1 |
| McGorray, SP | 1 |
| Sharaf, BL | 1 |
| Smith, KM | 1 |
| Olson, MB | 1 |
| Sopko, G | 1 |
| Handberg, E | 1 |
| Kerensky, RA | 1 |
| Peacock, WF | 1 |
| Emerman, CL | 1 |
| Young, J | 1 |
| Little, M | 2 |
| Pereira, PL | 1 |
| Mulcahy, R | 1 |
| Carrette, T | 1 |
| Seymour, J | 1 |
| Isbister, GK | 1 |
| Bonham, RJ | 1 |
| Shlipak, MG | 1 |
| Massie, BM | 1 |
| Gedevanishvili, A | 1 |
| Chamoun, A | 1 |
| Uretsky, BF | 1 |
| Rahman, AM | 1 |
| Stough, WG | 1 |
| O'Connor, CM | 1 |
| Gheorghiade, M | 1 |
| Sosnowski, C | 1 |
| Dabrowski, R | 1 |
| Wiernikowski, A | 1 |
| Rewicki, M | 1 |
| Ruzyłło, W | 1 |
| Mangieri, E | 1 |
| Tanzilli, G | 1 |
| De Vincentis, G | 1 |
| Barillà, F | 1 |
| Remediani, S | 1 |
| Acconcia, MC | 1 |
| Comito, C | 1 |
| Gaudio, C | 1 |
| Scopinaro, F | 1 |
| Puddu, PE | 1 |
| Critelli, G | 1 |
| Kawano, H | 1 |
| Yoshida, T | 1 |
| Miyao, Y | 1 |
| Hokamaki, J | 1 |
| Miyamoto, S | 1 |
| Miyazaki, Y | 1 |
| Nagayoshi, Y | 1 |
| Yamabe, H | 1 |
| Ogawa, H | 1 |
| Previsdomini, M | 1 |
| Stocker, R | 1 |
| Corti, R | 1 |
| Cerutti, B | 1 |
| Perren, A | 1 |
| Mira, E | 1 |
| Piacentino, G | 1 |
| Lanzi, G | 1 |
| Balottin, U | 1 |
| Fazzi, E | 1 |
| Levine, HJ | 1 |
| Nemerovski, M | 1 |
| Shah, PK | 1 |
| Koh, KK | 1 |
| Park, GS | 1 |
| Song, JH | 1 |
| Moon, TH | 1 |
| In, HH | 1 |
| Kim, JJ | 1 |
| Lee, HJ | 1 |
| Cho, SK | 1 |
| Kim, SS | 1 |
| Berrazueta, JR | 1 |
| Losada, A | 1 |
| Poveda, J | 1 |
| Ochoteco, A | 1 |
| Riestra, A | 1 |
| Salas, E | 1 |
| Amado, JA | 1 |
| Abrams, J | 1 |
| Chirkov, YY | 1 |
| Holmes, AS | 1 |
| Willoughby, SR | 1 |
| Stewart, S | 1 |
| Wuttke, RD | 1 |
| Sage, PR | 1 |
| Horowitz, JD | 1 |
| Littrell, KA | 1 |
| Kern, KB | 1 |
| Christiansen, J | 1 |
| Bruun, E | 1 |
| Skjoldbye, B | 1 |
| Hagen, KK | 1 |
| Wandner, V | 1 |
| Cerra, FB | 1 |
| Hassett, J | 1 |
| Siegel, JH | 1 |
| Page, A | 1 |
| Huret, JF | 1 |
| Roudaut, R | 1 |
| Baudet, M | 1 |
| Ferreira, A | 1 |
| Besse, P | 1 |
| Bourdarias, JP | 1 |
| Heyck, H | 1 |
| Gorlin, R | 1 |
| Magarian, GJ | 1 |
| Palac, R | 1 |
| Reinhart, S | 1 |
| Pozzati, A | 1 |
| Morgagni, GL | 1 |
| Ottani, F | 1 |
| Bugiardini, R | 1 |
| Lenzi, S | 1 |
| Puddu, P | 1 |
| Dobrzhanskaia, AK | 1 |
| Kosichkin, MM | 1 |
| Toivonen, LK | 1 |
| Pohjola-Sintonen, S | 1 |
| Betriu, A | 1 |
| Solignac, A | 1 |
| Bourassa, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack: a Cross-over, Randomized Controlled Study[NCT05718310] | 22 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| [NCT00000554] | Phase 3 | 0 participants | Interventional | 2001-05-31 | Completed | ||
| Non-invasive Fractional Flow Reserve CT (FFRCT) Scan for the Study of Coronary Vaso-motion[NCT02809157] | 10 participants (Anticipated) | Observational | 2014-10-31 | Active, not recruiting | |||
| The Effects of Traditional Acupuncture on Mechanisms of Coronary Heart Disease[NCT00570024] | 145 participants (Actual) | Interventional | 2006-01-31 | Completed | |||
| WISE Ancillary Study Data Analyses: Efficacy of Hormone Replacement on Myocardial Ischemia in Postmenopausal Women With Normal/Minimal Coronary Artery Disease: Data Analysis[NCT00600106] | 37 participants (Actual) | Interventional | 1999-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of endothelial dysfunction.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: Baseline
| Intervention | percentage of pre-stimulus diameter (Mean) |
|---|---|
| Hormone Replacement Therapy | 8.2 |
| Placebo | 8.8 |
"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: 12 weeks
| Intervention | percentage of pre-stimulus diameter (Mean) |
|---|---|
| Hormone Replacement Therapy | 8.8 |
| Placebo | 7.3 |
Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: 12 weeks
| Intervention | percent change in PCR/ATP ratio (Mean) |
|---|---|
| Hormone Replacement Therapy | -7.7 |
| Placebo | 1.1 |
Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: Baseline
| Intervention | percent changed in PCR/ATP ratio (Mean) |
|---|---|
| Hormone Replacement Therapy | -13.8 |
| Placebo | -7.0 |
"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Baseline
| Intervention | mm (Mean) |
|---|---|
| Hormone Replacement Therapy | -0.79 |
| Placebo | -0.79 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. (NCT00600106)
Timeframe: Baseline
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.8 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. (NCT00600106)
Timeframe: Exit (12 weeks)
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.4 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Baseline
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 5.4 |
| Placebo | 5.4 |
Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Exit at 12 weeks
| Intervention | metabolism equivalents (Mean) |
|---|---|
| Hormone Replacement Therapy | 6.1 |
| Placebo | 5.4 |
"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Exit (12 weeks)
| Intervention | mm (Mean) |
|---|---|
| Hormone Replacement Therapy | -1.05 |
| Placebo | -0.63 |
"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: 12 weeks
| Intervention | units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Physical functioning | Role-physical | Role-emotional | Bodily pain | General health | Mental health | Vitality | Social functioning | |
| Hormone Replacement Therapy | 59.4 | 58.8 | 76.5 | 54.5 | 55.2 | 66.4 | 35.6 | 59.4 |
| Placebo | 44.4 | 25.0 | 66.7 | 41.5 | 57.2 | 69.3 | 41.2 | 56.1 |
"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: Baseline
| Intervention | units on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Physical functioning | Role-physical | Role-emotional | Bodily pain | General health | Mental health | Vitality | Social functioning | |
| Hormone Replacement Therapy | 60.8 | 54.2 | 70.3 | 53.3 | 55.4 | 66.7 | 35.6 | 59.4 |
| Placebo | 43.8 | 37.3 | 66.7 | 42.1 | 57.4 | 65.7 | 42.9 | 53.2 |
Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: 12 weeks
| Intervention | percent of participants (Number) | ||||
|---|---|---|---|---|---|
| Hot flushes or flashing | Poor memory | Change in sexual desire | Vaginal dryness | Avoiding intimacy | |
| Hormone Replacement Therapy | 41 | 59 | 35 | 35 | 24 |
| Placebo | 89 | 78 | 67 | 67 | 56 |
Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: Baseline
| Intervention | percent of participants (Number) | ||||
|---|---|---|---|---|---|
| Hot flushes or flashing | Poor memory | Change in sexual desire | Vaginal dryness | Avoiding intimacy | |
| Hormone Replacement Therapy | 89 | 76 | 50 | 44 | 39 |
| Placebo | 68 | 53 | 37 | 58 | 37 |
5 reviews available for nitroglycerin and Syndrome
| Article | Year |
|---|---|
Nitrates for acute heart failure syndromes.
Topics: Acute Disease; Adult; Heart Failure; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Randomiz | 2013 |
Overview of current noninodilator therapies for acute heart failure syndromes.
Topics: Acute Disease; Angiotensin-Converting Enzyme Inhibitors; Digoxin; Diuretics; Heart Failure; Humans; | 2005 |
Difficult problems in the diagnosis of chest pain.
Topics: Angina Pectoris; Basal Cell Nevus Syndrome; Cardiomyopathy, Hypertrophic; Coronary Disease; Diagnosi | 1980 |
Medical therapy of unstable angina and non-Q-wave myocardial infarction.
Topics: Acute Disease; Adrenergic beta-Antagonists; Algorithms; Angina, Unstable; Biomarkers; Calcium Channe | 2000 |
Acute ischemic syndromes. Adjunctive therapy.
Topics: Acute Disease; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Chest | 2002 |
9 trials available for nitroglycerin and Syndrome
| Article | Year |
|---|---|
Vericiguat in Combination with Short-Acting Nitroglycerin in Patients With Chronic Coronary Syndromes: The Randomized, Phase Ib, VENICE Study.
Topics: Adult; Double-Blind Method; Heart Failure; Heterocyclic Compounds, 2-Ring; Humans; Nitroglycerin; Py | 2022 |
Role of 0.4 % glyceryl trinitrate ointment after stapled trans-anal rectal resection for obstructed defecation syndrome: a prospective, randomized trial.
Topics: Adult; Anal Canal; Anus Diseases; Defecation; Defecography; Digestive System Surgical Procedures; Hu | 2014 |
A prospective, randomized, controlled trial of benzodiazepines and nitroglycerine or nitroglycerine alone in the treatment of cocaine-associated acute coronary syndromes.
Topics: Acute Disease; Adult; Angina Pectoris; Anti-Anxiety Agents; Cocaine; Drug Therapy, Combination; Fema | 2003 |
Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease.
Topics: Aged; Atorvastatin; Blood Flow Velocity; Blood Pressure; Cholesterol, HDL; Cholesterol, LDL; Coronar | 2003 |
[Nitroglycerin efficacy in acute coronary syndrome at a prehospital stage. Results of randomized open multicenter study of prehospital use of intravenous and sublingual forms of nitroglycerine in patients with acute coronary syndrome].
Topics: Acute Disease; Administration, Sublingual; Adolescent; Adult; Angina, Unstable; Blood Pressure; Data | 2003 |
Nesiritide in congestive heart failure associated with acute coronary syndromes: a pilot study of safety and efficacy.
Topics: Acute Disease; Cardiac Catheterization; Coronary Disease; Double-Blind Method; Female; Heart Failure | 2004 |
Interaction of intravenous heparin and organic nitrates in acute ischemic syndromes.
Topics: Acute Disease; Aged; Analysis of Variance; Anticoagulants; Antithrombin III; Drug Interactions; Fema | 1995 |
Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study.
Topics: Administration, Cutaneous; Adult; Analgesia; Double-Blind Method; Female; Humans; Male; Middle Aged; | 1996 |
[Chronic idiopathic anal pain syndrome].
Topics: Adult; Anal Canal; Analgesics; Anus Diseases; Botulinum Toxins; Chronic Disease; Colostomy; Female; | 2002 |
34 other studies available for nitroglycerin and Syndrome
| Article | Year |
|---|---|
Experts' Consensus on Use of Long-Acting Nitroglycerine in the Management of Angina and Chronic Coronary Syndrome in India.
Topics: Angina Pectoris; Cardiovascular Agents; Humans; India; Nitroglycerin; Percutaneous Coronary Interven | 2022 |
High-dose nitroglycerin infusion for the management of sympathetic crashing acute pulmonary edema (SCAPE): A case series.
Topics: Acute Disease; Aged; Female; Heart Failure; Humans; Infusions, Intravenous; Male; Middle Aged; Nitro | 2021 |
Gynaecological transurethral resection of the prostate syndrome-induced acute pulmonary oedema treated with high-dose nitro-glycerine: a case report.
Topics: Acute Disease; Female; Humans; Hysteroscopy; Intraoperative Complications; Medical Illustration; Mid | 2020 |
The migraine postdrome: Spontaneous and triggered phenotypes.
Topics: Adolescent; Adult; Fatigue; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nausea; | 2021 |
Brachial artery constriction during brachial artery reactivity testing predicts major adverse clinical outcomes in women with suspected myocardial ischemia: results from the NHLBI-sponsored women's ischemia Syndrome Evaluation (WISE) Study.
Topics: Adult; Aged; Aged, 80 and over; Brachial Artery; Female; Follow-Up Studies; Humans; Middle Aged; Mod | 2013 |
A case of coronary spasm with resultant acute myocardial infarction: likely the result of an allergic reaction.
Topics: Adult; Angina Pectoris; Anti-Bacterial Agents; Ceftriaxone; Coronary Angiography; Coronary Vasospasm | 2012 |
Resolution of refractory no-reflow with intracoronary epinephrine.
Topics: Abciximab; Acute Disease; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Bl | 2002 |
Nitroglycerin-aggravated pre-eclamptic posterior reversible encephalopathy syndrome (PRES).
Topics: Adult; Brain; Brain Diseases; Female; Humans; Magnetic Resonance Imaging; Nitroglycerin; Pre-Eclamps | 2003 |
Distal filter protection during percutaneous coronary intervention in native coronary arteries and saphenous vein grafts in patients with acute coronary syndromes.
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Balloon Occlusion; Biomarkers; Blood Vessel Pro | 2003 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).
Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co | 2004 |
Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome.
Topics: Animals; Bites and Stings; Cnidarian Venoms; Emergency Medical Services; Humans; Hypertension; Nitro | 2004 |
Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome.
Topics: Animals; Bites and Stings; Cnidarian Venoms; Emergency Medical Services; Humans; Hypertension; Magne | 2004 |
Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome.
Topics: Animals; Bites and Stings; Chest Pain; Cnidarian Venoms; Emergency Medical Services; Humans; Hyperte | 2004 |
The clinical challenge of cardiorenal syndrome.
Topics: Angiotensin-Converting Enzyme Inhibitors; Case Management; Cohort Studies; Creatinine; Disease Progr | 2004 |
Acute coronary syndrome induced by intravenous ephedrine in pregnant woman with normal coronaries.
Topics: Acute Disease; Adult; Anesthesia, Obstetrical; Cesarean Section; Coronary Angiography; Coronary Dise | 2004 |
Failure of magnesium in treatment of Irukandji syndrome.
Topics: Adult; Analgesics; Analgesics, Opioid; Bites and Stings; Bronchodilator Agents; Cnidarian Venoms; Ep | 2005 |
Coronary artery stent placement as a treatment of acute coronary syndrome in course of variant angina.
Topics: Angina Pectoris, Variant; Coronary Angiography; Coronary Stenosis; Female; Humans; Male; Middle Aged | 2006 |
Slow coronary flow and stress myocardial perfusion imaging. Different patterns in acute patients.
Topics: Acute Disease; Adult; Blood Pressure; Case-Control Studies; Coronary Angiography; Coronary Circulati | 2006 |
The relationship between endothelial function in the brachial artery and intima plus media thickening of the coronary arteries in patients with chest pain syndrome.
Topics: Aged; Arterial Occlusive Diseases; Brachial Artery; Chest Pain; Coronary Vessels; Endothelium, Vascu | 2007 |
A 66-year-old man has an unexpected low cardiac output syndrome during repeat myocardial revascularization.
Topics: Aged; Angina, Unstable; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output, Low; Cardiotonic Age | 1988 |
Time course of hemoglobin concentrations in the intensive care unit in nonbleeding patients with acute coronary syndrome.
Topics: Acute Disease; Aged; Coronary Care Units; Coronary Disease; Drug Therapy, Combination; Electrocardio | 2007 |
Benign paroxysmal vertigo in childhood: a migraine equivalent.
Topics: Child; Child, Preschool; Female; Fenfluramine; Histamine; Humans; Male; Migraine Disorders; Nitrogly | 1984 |
Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration.
Topics: Aged; Bradycardia; Coronary Disease; Humans; Hypotension; Male; Middle Aged; Nitroglycerin; Syndrome | 1981 |
Stable angina and acute coronary syndromes are associated with nitric oxide resistance in platelets.
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Blood Platelets; Coronary Disease; Female; Humans; Male | 2001 |
[The angina pectoris syndrome. II. Therapeutic principles].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium; Cardiac Glycosides; Humans; Nitroglycerin; Ni | 1979 |
Vasodilator therapy in clinical sepsis with low output syndrome.
Topics: Aged; Cardiac Output; Humans; Middle Aged; Nitroglycerin; Shock, Cardiogenic; Shock, Septic; Syndrom | 1978 |
[Intravenous trinitroglycerin in the treatment of pre-infarction syndrome. Preliminary results (author's transl)].
Topics: Aged; Angina Pectoris; Blood Pressure; Cardiac Output; Cardiomyopathies; Drug Resistance; Female; He | 1979 |
[Cluster headache].
Topics: Age Factors; Ethanol; Headache; Humans; Nitroglycerin; Rest; Seasons; Sex Factors; Syndrome; Time Fa | 1975 |
The syndromes of cardiac pain.
Topics: Angina Pectoris; Angina Pectoris, Variant; Cardiomyopathies; Coronary Angiography; Coronary Circulat | 1976 |
Syndrome of diminished vasodilator reserve of the coronary microcirculation (microvascular angina or syndrome X): diagnosis by combined atrial pacing and thallium 201 imaging--a case report.
Topics: Angina Pectoris; Cardiac Pacing, Artificial; Coronary Vessels; Female; Humans; Microcirculation; Mid | 1990 |
[Abnormal coronary response to vasomotor stimuli: analogies between variant angina and X syndrome].
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Arteriosclerosis; Coronary Disease; Coronary | 1989 |
[Features of peripheral circulatory disorders in patients with progressive muscular dystrophies].
Topics: Adolescent; Adult; Blood Circulation; Disability Evaluation; Extremities; Humans; Middle Aged; Muscu | 1987 |
Vasodilator therapy-induced pacemaker syndrome.
Topics: Humans; Hypotension; Male; Middle Aged; Nifedipine; Nitroglycerin; Pacemaker, Artificial; Syncope; S | 1987 |
The variant form of angina: diagnostic and therapeutic implications.
Topics: Adult; Angina Pectoris; Angiocardiography; Cineangiography; Coronary Artery Bypass; Diagnosis, Diffe | 1974 |