Page last updated: 2024-11-01

nitroglycerin and Syncope

nitroglycerin has been researched along with Syncope in 64 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)

Research Excerpts

ExcerptRelevanceReference
" The aim of this article is to evaluate, in an elderly population with unexplained syncope, whether the impact of sublingual nitroglycerin (NTG) used as a provocative agent is dose-dependent."9.13Head-up tilt testing with different nitroglycerin dosages: experience in elderly patients with unexplained syncope. ( Antunes, E; da Silva, MN; Feliciano, J; Ferreira, R; Oliveira, MM; Santos, S; Silva, S; Timoteo, AT, 2008)
"It is unknown if the head-upright tilt test in patients who receive isoproterenol and nitroglycerin can identify different populations with vasovagal syncope."9.10Comparison between isoproterenol and nitroglycerin sensitized head-upright tilt in patients with unexplained syncope and negative or positive passive head-up tilt response. ( Delépine, S; Dupuis, J; Geslin, P; Lefthériotis, G; Prunier, F; Victor, J; Vielle, B, 2002)
"The head-up tilt test (TT) performed after sublingual nitroglycerine application (NTG) is a tool that is commonly accepted and widely used in diagnosing patients with unexplained syncope."9.10[Usefulness of the tilt test with nitroglycerine application in diagnosing of patients with unexplained syncope: new aspects of the well-known problem]. ( Cholewa, M; Dłuzniewska, E; Gielerak, G; Makowski, K; Roszczyk, A, 2003)
"Head-up tilt testing potentiated by sublingual nitroglycerin (NTG), advocated by an Italian group, is a simple and safe but still not a standardized, diagnostic tool for the investigation of syncope."9.09'The Italian Protocol': a simplified head-up tilt testing potentiated with oral nitroglycerin to assess patients with unexplained syncope. ( Alboni, P; Ammirati, F; Bartoletti, A; Brignole, M; Del Rosso, A; Foglia Manzillo, G; Menozzi, C; Raviele, A; Sutton, R, 2000)
"The findings suggest that nitroglycerin triggers head-up tilt-induced syncope by increasing epinephrine levels, whereas isoproterenol induces syncope by decreasing left ventricular volume."9.09Different mechanisms of isoproterenol-induced and nitroglycerin-induced syncope during head-up tilt in patients with unexplained syncope: important role of epinephrine in nitroglycerin-induced syncope. ( Isojima, K; Kurita, A; Nishioka, T; Ohsuzu, F; Satomura, K; Takase, B; Uehata, A, 2001)
"The aim of our study was to evaluate the prevalence and clinical predictors of cardioinhibitory (CI) responses with asystole at the nitroglycerin (NTG)-potentiated head-up tilt test (HUTT) in patients with a history of syncope admitted to a tertiary referral syncope unit."8.12Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors. ( Brignole, M; Chamberland, C; Comune, A; Golino, P; Huynh, T; Laezza, N; Nigro, G; Papa, AA; Parente, E; Rago, A; Russo, V, 2022)
"The aim of this prospective study was to assess the diagnostic value of a sublingual nitroglycerin (NTG) potentiated head-up tilt (HUT) testing protocol in children with unexplained syncope."7.74Tilt testing potentiated with sublingual nitroglycerin in children with unexplained syncope. ( Foglia-Manzillo, G; Fteita, N; Giada, F; Nessi, I; Raviele, A; Santarone, M, 2007)
" Nitroglycerin provocation tilt is a useful modality for evaluating neurally mediated syncope."7.72Endogenous opioids and epinephrine in nitroglycerin provocation tilt test in patients with neurally mediated syncope. ( Katsushika, S; Kurita, A; Matsushima, Y; Ohsuzu, F; Sato, T; Satomura, K; Takase, B; Umeda, E, 2003)
"Nitroglycerin (NTG) administration occasionally leads to syncope due to severe hypotension and bradycardia."7.71Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action. ( Ceska, R; Hradec, J; Malik, J; Malik, M; Melenovsky, V; Simek, J; Wichterle, D, 2002)
"Short-duration head-up tilt test potentiated with sublingual nitroglycerin provides an adequate specificity and positivity rate in patients with unexplained syncope."7.70Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. ( Bartoletti, A; Bartoli, P; Bonechi, F; Brandinelli-Geri, A; Del Rosso, A; Fierro, A; Ieri, A; Maioli, M; Mazza, F; Michelucci, A; Russo, L; Salvetti, E; Sansoni, M; Zipoli, A, 1998)
"Head-up tilt testing (HUTT) potentiated with sublingual nitroglycerin has gained acceptance as means of diagnosing neurally mediated syncope."7.70Reproducibility of head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. ( Beretta, S; Corrado, G; Foglia-Manzillo, G; Giada, F; Raviele, A; Santarone, M, 1999)
"The aim of our present study was to assess the value of nitroglycerin infusion during upright posture as a new provocative test for diagnosis of vasovagal syncope."7.69Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. ( Alboni, P; Brignole, M; Di Pede, F; Dinelli, M; Gasparini, G; Menozzi, C; Piccolo, E; Raviele, A, 1994)
"This study was undertaken to assess the value of sublingual nitroglycerin administration during upright tilt as a simple practical test for the diagnosis of vasovagal syncope."7.69Value of head-up tilt testing potentiated with sublingual nitroglycerin to assess the origin of unexplained syncope. ( Alboni, P; Brignole, M; Dinelli, M; Gasparini, G; Lolli, G; Menozzi, C; Mureddu, R; Musso, G; Oddone, D; Raviele, A, 1995)
" Particular attention was reserved to some controversial topics, such as the tilting angle, the duration of the passive and pharmacological stages of the test, the type and dosage of the drug utilized."6.41[The tilt test enhanced with oral nitroglycerin in patients with unexplained syncope: the Italian Protocol. The Working Group on Syncope of the Associazione Italiana di Aritmologia e Cardiostimolazione--the Arrhythmia Area of the Associazione Nazionale Me ( Alboni, P; Ammirati, F; Bartoletti, A; Brignole, M; Del Rosso, A; Foglia Manzillo, G; Menozzi, C; Raviele, A, 2000)
"The median time of syncopal episode occurred after NTG administration in the ALDH2*1/*1 group was 6 min (interquartile range [IQR]: 5."5.72The effects of ALDH2 Glu487Lys polymorphism on vasovagal syncope patients undergoing head-up tilt test supplemented with sublingual nitroglycerin. ( Hu, B; Jin, JF; Pu, JL; Wang, XD; Xia, G; Ye, Y, 2022)
" The aim of this article is to evaluate, in an elderly population with unexplained syncope, whether the impact of sublingual nitroglycerin (NTG) used as a provocative agent is dose-dependent."5.13Head-up tilt testing with different nitroglycerin dosages: experience in elderly patients with unexplained syncope. ( Antunes, E; da Silva, MN; Feliciano, J; Ferreira, R; Oliveira, MM; Santos, S; Silva, S; Timoteo, AT, 2008)
"It is unknown if the head-upright tilt test in patients who receive isoproterenol and nitroglycerin can identify different populations with vasovagal syncope."5.10Comparison between isoproterenol and nitroglycerin sensitized head-upright tilt in patients with unexplained syncope and negative or positive passive head-up tilt response. ( Delépine, S; Dupuis, J; Geslin, P; Lefthériotis, G; Prunier, F; Victor, J; Vielle, B, 2002)
"The head-up tilt test (TT) performed after sublingual nitroglycerine application (NTG) is a tool that is commonly accepted and widely used in diagnosing patients with unexplained syncope."5.10[Usefulness of the tilt test with nitroglycerine application in diagnosing of patients with unexplained syncope: new aspects of the well-known problem]. ( Cholewa, M; Dłuzniewska, E; Gielerak, G; Makowski, K; Roszczyk, A, 2003)
"Head-up tilt testing potentiated by sublingual nitroglycerin (NTG), advocated by an Italian group, is a simple and safe but still not a standardized, diagnostic tool for the investigation of syncope."5.09'The Italian Protocol': a simplified head-up tilt testing potentiated with oral nitroglycerin to assess patients with unexplained syncope. ( Alboni, P; Ammirati, F; Bartoletti, A; Brignole, M; Del Rosso, A; Foglia Manzillo, G; Menozzi, C; Raviele, A; Sutton, R, 2000)
"The findings suggest that nitroglycerin triggers head-up tilt-induced syncope by increasing epinephrine levels, whereas isoproterenol induces syncope by decreasing left ventricular volume."5.09Different mechanisms of isoproterenol-induced and nitroglycerin-induced syncope during head-up tilt in patients with unexplained syncope: important role of epinephrine in nitroglycerin-induced syncope. ( Isojima, K; Kurita, A; Nishioka, T; Ohsuzu, F; Satomura, K; Takase, B; Uehata, A, 2001)
"Little is still known about the positivity rate of nitroglycerin (NTG) potentiated head-up tilt test (HUTT) according to the history-based clinical features of syncope."4.31The clinical presentation of syncope influences the head-up tilt test responses. ( Brignole, M; Comune, A; Golino, P; Laezza, N; Nigro, G; Parente, E; Rago, A; Russo, V, 2023)
"The aim of our study was to evaluate the prevalence and clinical predictors of cardioinhibitory (CI) responses with asystole at the nitroglycerin (NTG)-potentiated head-up tilt test (HUTT) in patients with a history of syncope admitted to a tertiary referral syncope unit."4.12Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors. ( Brignole, M; Chamberland, C; Comune, A; Golino, P; Huynh, T; Laezza, N; Nigro, G; Papa, AA; Parente, E; Rago, A; Russo, V, 2022)
" According to the nitroglycerin-potentiated diagnostic tilt test response, the study population was divided into two groups: HUTT+ Group (61 patients, mean age 37 ± 10; 27 male) and HUTT- Group (34 patients, mean age 38 ± 11; 15 male) with no tilt-induced syncope."3.81Which hemodynamic parameter predicts nitroglycerin-potentiated head-up tilt test response? ( Calabrò, P; Ciardiello, C; Nigro, G; Papa, AA; Proietti, R; Rago, A; Russo, MG; Russo, V, 2015)
" These findings indicated reduced arterial resistance in nitroglycerin-induced presyncope."3.77Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test. ( Ilveskoski, E; Kähönen, M; Kööbi, T; Koskela, J; Leskinen, M; Mustonen, J; Nordhausen, K; Pörsti, I; Tahvanainen, A, 2011)
"To evaluate, in a population referred for syncope of unknown etiology, the value of tilt testing with sublingual nitroglycerin and to compare the responses obtained in elderly and younger patients."3.74Use of nitroglycerin in the active phase of tilt testing: is there a difference in elderly patients? ( Antunes, E; Feliciano, J; Ferreira, R; Oliveira, M; Pelicano, N; Quininha, J; Silva, S; Timóteo, AT, 2007)
"The aim of this prospective study was to assess the diagnostic value of a sublingual nitroglycerin (NTG) potentiated head-up tilt (HUT) testing protocol in children with unexplained syncope."3.74Tilt testing potentiated with sublingual nitroglycerin in children with unexplained syncope. ( Foglia-Manzillo, G; Fteita, N; Giada, F; Nessi, I; Raviele, A; Santarone, M, 2007)
"Sublingual nitroglycerin is advocated to sensitize the passive 70 degrees head-upright tilt test (HUTT) of patients with unexplained syncope."3.73Late hemodynamic changes during a negative passive head-up tilt predict the symptomatic outcome to a nitroglycerin sensitized tilt. ( Bellard, E; Dupuis, JM; Fortrat, JO; Lefthériotis, G; Schang, D; Victor, J, 2005)
" Nitroglycerin provocation tilt is a useful modality for evaluating neurally mediated syncope."3.72Endogenous opioids and epinephrine in nitroglycerin provocation tilt test in patients with neurally mediated syncope. ( Katsushika, S; Kurita, A; Matsushima, Y; Ohsuzu, F; Sato, T; Satomura, K; Takase, B; Umeda, E, 2003)
"Nitroglycerin (NTG) administration occasionally leads to syncope due to severe hypotension and bradycardia."3.71Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action. ( Ceska, R; Hradec, J; Malik, J; Malik, M; Melenovsky, V; Simek, J; Wichterle, D, 2002)
"Short-duration head-up tilt test potentiated with sublingual nitroglycerin provides an adequate specificity and positivity rate in patients with unexplained syncope."3.70Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. ( Bartoletti, A; Bartoli, P; Bonechi, F; Brandinelli-Geri, A; Del Rosso, A; Fierro, A; Ieri, A; Maioli, M; Mazza, F; Michelucci, A; Russo, L; Salvetti, E; Sansoni, M; Zipoli, A, 1998)
"Head-up tilt testing (HUTT) potentiated with sublingual nitroglycerin has gained acceptance as means of diagnosing neurally mediated syncope."3.70Reproducibility of head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. ( Beretta, S; Corrado, G; Foglia-Manzillo, G; Giada, F; Raviele, A; Santarone, M, 1999)
" In both patients, hyperventilation test caused severe myocardial ischaemia (ST segment elevation) and sudden development of presyncopal sustained ventricular tachycardia which immediately responded to intravenous nitroglycerin."3.69[Syncope and chest pain. Demonstration of the mechanism by the hyperventilation test]. ( Alcalá López, JE; Alvarez López, M; Azpitarte Almagro, J; Baún Mellado, O, 1995)
"This study was undertaken to assess the value of sublingual nitroglycerin administration during upright tilt as a simple practical test for the diagnosis of vasovagal syncope."3.69Value of head-up tilt testing potentiated with sublingual nitroglycerin to assess the origin of unexplained syncope. ( Alboni, P; Brignole, M; Dinelli, M; Gasparini, G; Lolli, G; Menozzi, C; Mureddu, R; Musso, G; Oddone, D; Raviele, A, 1995)
"The aim of our present study was to assess the value of nitroglycerin infusion during upright posture as a new provocative test for diagnosis of vasovagal syncope."3.69Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. ( Alboni, P; Brignole, M; Di Pede, F; Dinelli, M; Gasparini, G; Menozzi, C; Piccolo, E; Raviele, A, 1994)
"Within a half-year period, we encountered six cases of patients harmed by the adverse effects of self-administered nitroglycerin--syncope, delayed definitive medical care, and the worsening of nonischemic symptoms."3.68Defining the proper role for self-administered sublingual nitroglycerin. A survey of physicians and patients. ( Bassan, M, 1991)
"Nitrates rarely cause coronary steal and myocardial ischaemia."2.43Side effects of using nitrates to treat angina. ( Rodgers, T; Thadani, U, 2006)
" Particular attention was reserved to some controversial topics, such as the tilting angle, the duration of the passive and pharmacological stages of the test, the type and dosage of the drug utilized."2.41[The tilt test enhanced with oral nitroglycerin in patients with unexplained syncope: the Italian Protocol. The Working Group on Syncope of the Associazione Italiana di Aritmologia e Cardiostimolazione--the Arrhythmia Area of the Associazione Nazionale Me ( Alboni, P; Ammirati, F; Bartoletti, A; Brignole, M; Del Rosso, A; Foglia Manzillo, G; Menozzi, C; Raviele, A, 2000)
"The median time of syncopal episode occurred after NTG administration in the ALDH2*1/*1 group was 6 min (interquartile range [IQR]: 5."1.72The effects of ALDH2 Glu487Lys polymorphism on vasovagal syncope patients undergoing head-up tilt test supplemented with sublingual nitroglycerin. ( Hu, B; Jin, JF; Pu, JL; Wang, XD; Xia, G; Ye, Y, 2022)
"Thirteen patients had orthostatic hypotension (OH)."1.48Monitoring of cerebral oximetry during head-up tilt test in adults with history of syncope and orthostatic intolerance. ( Bachus, E; Fedorowski, A; Hamrefors, V; Holm, H; Magnusson, M; Melander, O; Sutton, R, 2018)
"Syncope is a common condition."1.40Poor diagnostic performance of tilt testing in hypertensive patients with unexplained syncope. ( Ceccofiglio, A; Cellai, T; Del Rosso, A; Marchionni, N; Mussi, C; Rafanelli, M; Ungar, A, 2014)
"Syncope is a common cause of acute hospitalization and may be associated with poor quality of life."1.35[Investigation in suspected syncope. A study of more than 1,174 consecutively referred patients]. ( Mehlsen, AB; Mehlsen, J, 2008)
"After the procedure both symptoms and orthostatic hypotension disappeared."1.35Persistent atrial fibrillation associated with syncope due to orthostatic hypotension: a case report. ( Baratella, MC; D'este, D; Reato, S, 2009)
"Syncope is a frequent complaint which imposes a considerable burden on the health care systems."1.34[Pseudosyncope and pseudoseizure]. ( Abrahám, G; Benedek, K; Beniczky, S; Pálinkás, A; Rudas, L; Vécsei, L, 2007)
"Type of vasovagal syncope was defined according to American Experts Classification described in official guidelines of American College of Cardiology (ACC)."1.31[Estimation of head-up tilt test in diagnosis of syncope of unknown origin. Can we come up with better results?]. ( Cholewa, M; Gielerak, G, 2002)
" Carefully designed dosing regimens and/or appropriate use of nitrate formulations (to include a nitrate-free period each day) will decrease or eliminate the problem of nitrate tolerance."1.29Therapy of angina pectoris with long-acting nitrates: which agent and when? ( Abrams, J, 1996)

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-19908 (12.50)18.7374
1990's11 (17.19)18.2507
2000's29 (45.31)29.6817
2010's9 (14.06)24.3611
2020's7 (10.94)2.80

Authors

AuthorsStudies
Russo, V4
Parente, E3
Rago, A4
Comune, A3
Laezza, N3
Papa, AA2
Chamberland, C1
Huynh, T1
Golino, P3
Brignole, M9
Nigro, G4
Xia, G1
Jin, JF1
Ye, Y1
Wang, XD1
Hu, B1
Pu, JL1
Tomaino, M1
Sabatini, A1
Carretta, D1
Meglič, B1
Danieli, A1
Tajdini, M1
Aminorroaya, A1
Rahimi, B1
Mortazavi, SH1
Vasheghani Farahani, A1
Sadeghian, S1
Easapour Moghadam, M1
Soltani, D1
Bozorgi, A1
Ghariq, M1
Thijs, RD1
Bek, LM1
van Zwet, EW1
Benditt, DG1
van Dijk, JG1
Bachus, E1
Holm, H1
Hamrefors, V1
Melander, O1
Sutton, R2
Magnusson, M1
Fedorowski, A1
Malik, SA1
Porter, TT1
Pavlides, G1
Chatzizisis, Y1
Rafanelli, M2
Morrione, A1
Del Rosso, A8
Marchionni, N3
Ungar, A4
Cellai, T2
Ceccofiglio, A1
Mussi, C2
Couceiro, R1
Carvalho, P1
Paiva, RP1
Muehlsteff, J1
Henriques, J1
Eickholt, C1
Brinkmeyer, C1
Kelm, M1
Meyer, C1
Ciardiello, C1
Proietti, R1
Calabrò, P1
Russo, MG1
Wittig, T1
Timoteo, AT2
Oliveira, MM1
Feliciano, J2
Antunes, E2
da Silva, MN1
Silva, S2
Santos, S1
Ferreira, R2
Dhawan, SS1
Shirwany, A1
Reato, S1
Baratella, MC1
D'este, D1
Tahvanainen, A1
Koskela, J1
Leskinen, M1
Ilveskoski, E1
Nordhausen, K1
Kähönen, M1
Kööbi, T1
Mustonen, J1
Pörsti, I1
Furukawa, T1
Maggi, R1
Solano, A1
Croci, F1
Lin, P1
Wang, C1
Cao, MJ1
Luo, HY1
Xu, Y1
Xie, ZW1
Bartoli, P3
Masotti, G1
Delépine, S1
Prunier, F1
Lefthériotis, G2
Dupuis, J1
Vielle, B1
Geslin, P1
Victor, J2
Gielerak, G3
Cholewa, M4
Fisher, JD1
Kim, SG1
Ferrick, KJ1
Gross, JN1
Palma, EC1
Scavin, GM1
Takase, B2
Matsushima, Y1
Umeda, E1
Satomura, K2
Katsushika, S1
Ohsuzu, F2
Sato, T1
Kurita, A2
Leinonen, P1
Makowski, K3
Dłuzniewska, E2
Roszczyk, A2
Bartoletti, A5
Nava, S1
Mont, L1
Silva, RM1
Rogel, U1
Osorio, P1
Bartholomay, E1
Berruezo, A1
Chueca, E1
Brugada, J1
Gieroba, ZJ1
Newton, JL1
Parry, SW1
Norton, M1
Lawson, J1
Kenny, RA1
Bellard, E1
Fortrat, JO1
Schang, D1
Dupuis, JM1
Gierelak, G1
Guzik, P1
Kramarz, E1
Kowal, J1
Thadani, U1
Rodgers, T1
Benedek, K1
Pálinkás, A1
Abrahám, G1
Beniczky, S1
Vécsei, L1
Rudas, L1
Oliveira, M1
Pelicano, N1
Quininha, J1
Foglia-Manzillo, G2
Giada, F2
Fteita, N1
Nessi, I1
Santarone, M2
Raviele, A6
Mehlsen, AB1
Mehlsen, J1
Jastrzebska-Maj, E1
Mizia-Stec, K1
Jakubowski, D1
Sugrue, DD1
Wood, DL1
McGoon, MD1
Alcalá López, JE1
Azpitarte Almagro, J1
Alvarez López, M1
Baún Mellado, O1
Menozzi, C4
Gasparini, G2
Alboni, P4
Musso, G1
Lolli, G1
Oddone, D1
Dinelli, M2
Mureddu, R1
Mauric, A1
Samani, NJ1
de Bono, DP1
Di Pede, F1
Piccolo, E1
Abrams, J1
Brandinelli-Geri, A1
Bonechi, F2
Maioli, M2
Mazza, F1
Michelucci, A1
Russo, L1
Salvetti, E1
Sansoni, M1
Zipoli, A1
Fierro, A1
Ieri, A2
Gardini, A1
Benedini, G1
Proto, C1
Natale, A1
Sra, J1
Akhtar, M1
Kusmirek, L1
Tomassoni, G1
Leonelli, F1
Newby, K1
Beheiry, S1
Pacifico, A1
Oraii, S1
Maleki, M1
Minooii, M1
Kafaii, P1
Beretta, S1
Corrado, G1
Ammirati, F2
Foglia Manzillo, G2
Calkins, H1
Uehata, A1
Nishioka, T1
Isojima, K1
Melenovsky, V1
Wichterle, D1
Malik, J1
Simek, J1
Hradec, J1
Ceska, R1
Malik, M1
Verrill, PJ1
Bassan, M1
Tatár, P1
Bulas, J1
Kvetnanský, R1
Strec, V1
Toivonen, LK1
Pohjola-Sintonen, S1
Nilsson, G1
Wretborn, M1
Powell, WJ1
Whiting, RB1
Dinsmore, RE1
Sanders, CA1
Lanfranchi, A1
Beraud, P1
Nager, F1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
New Perspective on Exploring the Post-apneic Blood Pressure Surge in Patients With Obstructive Sleep Apnea[NCT06172998]Early Phase 1350 participants (Anticipated)Interventional2022-04-01Recruiting
Effects of Insulin on Hypotension and Sarcopenia[NCT03248271]0 participants (Actual)Observational2017-10-01Withdrawn (stopped due to Study design was changed to the study was changed to Insulin, hypotension and sarcopenia.)
The Effect of Capsaicin-Phenylephrine-Caffeine Formulation on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope[NCT04972123]Phase 2140 participants (Actual)Interventional2021-07-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for nitroglycerin and Syncope

ArticleYear
Vasospastic Angina Presenting With Syncope and Chest Pain: A Case Report and Brief Literature Review.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2017, Volume: 70, Issue:11

    Topics: Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Chest Pain; Coronary Angiography; Coronary

2017
Side effects of using nitrates to treat angina.
    Expert opinion on drug safety, 2006, Volume: 5, Issue:5

    Topics: Angina Pectoris; Coronary Disease; Drug Interactions; Headache; Humans; Isosorbide Dinitrate; Nitrat

2006
[The tilt test enhanced with oral nitroglycerin in patients with unexplained syncope: the Italian Protocol. The Working Group on Syncope of the Associazione Italiana di Aritmologia e Cardiostimolazione--the Arrhythmia Area of the Associazione Nazionale Me
    Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2000, Volume: 1, Issue:2

    Topics: Administration, Oral; Cardiology; Clinical Protocols; Humans; Italy; Nitroglycerin; Societies, Medic

2000
Isoproterenol-provoked versus nitroglycerin-provoked tilt tests: do they differ?
    Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:7

    Topics: Humans; Isoproterenol; Nitroglycerin; Syncope; Tilt-Table Test

2001

Trials

13 trials available for nitroglycerin and Syncope

ArticleYear
Short-duration head-up tilt test potentiated with sublingual nitroglycerin in suspected vasovagal syncope: the fast Italian protocol.
    European heart journal, 2023, Jul-14, Volume: 44, Issue:27

    Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Nitroglycerin; Randomized Controlled Trials as Topic

2023
Comparison of trinitroglycerin and adenosine as provocative agents for head-up tilt test in patients with unexplained syncope: a semi-crossover randomized clinical trial with prospective follow-up.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2021, Volume: 60, Issue:1

    Topics: Adenosine; Female; Follow-Up Studies; Humans; Male; Nitroglycerin; Prospective Studies; Syncope; Syn

2021
Head-up tilt testing with different nitroglycerin dosages: experience in elderly patients with unexplained syncope.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2008, Volume: 10, Issue:9

    Topics: Aged; Dose-Response Relationship, Drug; Female; Head-Down Tilt; Humans; Male; Nitroglycerin; Reprodu

2008
Usefulness and safety of shortened head-up tilt testing potentiated with sublingual glyceryl trinitrate in older patients with recurrent unexplained syncope.
    Journal of the American Geriatrics Society, 2002, Volume: 50, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Electrocardiography; Female; Head; Heart Rate; Human

2002
Comparison between isoproterenol and nitroglycerin sensitized head-upright tilt in patients with unexplained syncope and negative or positive passive head-up tilt response.
    The American journal of cardiology, 2002, Sep-01, Volume: 90, Issue:5

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Age Factors; Aged; Female; France; Heart Rate; Humans;

2002
[Usefulness of the tilt test with nitroglycerine application in diagnosing of patients with unexplained syncope: new aspects of the well-known problem].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2003, Volume: 15, Issue:85

    Topics: Adolescent; Adult; Aged; Female; Head-Down Tilt; Humans; Male; Middle Aged; Nitroglycerin; Severity

2003
Short head-up tilt test potentiated with oral nitroglycerine: comparison with a conventional test using isoproterenol.
    Pacing and clinical electrophysiology : PACE, 2004, Volume: 27, Issue:8

    Topics: Female; Heart Diseases; Humans; Isoproterenol; Male; Middle Aged; Nitroglycerin; Syncope; Tilt-Table

2004
Use of sublingual nitroglycerin during head-up tilt-table testing in patients >60 years of age.
    The American journal of cardiology, 1998, Nov-15, Volume: 82, Issue:10

    Topics: Administration, Sublingual; Aged; Bradycardia; Cardiotonic Agents; Dose-Response Relationship, Drug;

1998
Comparing two different protocols for tilt table testing: sublingual glyceryl trinitrate versus isoprenaline infusion.
    Heart (British Cardiac Society), 1999, Volume: 81, Issue:6

    Topics: Adolescent; Adult; Cardiotonic Agents; Female; Humans; Isoproterenol; Male; Middle Aged; Nitroglycer

1999
Methodology of head-up tilt testing potentiated with sublingual nitroglycerin in unexplained syncope.
    The American journal of cardiology, 2000, Apr-15, Volume: 85, Issue:8

    Topics: Administration, Sublingual; Adult; Female; Humans; Male; Nitroglycerin; Reproducibility of Results;

2000
'The Italian Protocol': a simplified head-up tilt testing potentiated with oral nitroglycerin to assess patients with unexplained syncope.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2000, Volume: 2, Issue:4

    Topics: Administration, Oral; Adult; Aged; Female; Humans; Italy; Male; Middle Aged; Nitroglycerin; Sensitiv

2000
Different mechanisms of isoproterenol-induced and nitroglycerin-induced syncope during head-up tilt in patients with unexplained syncope: important role of epinephrine in nitroglycerin-induced syncope.
    Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Volume; Epinephrine; Female; Head-Down Tilt; Human

2001
Venous plasma adrenaline response to orthostatic syncope during tilting in healthy men.
    Clinical physiology (Oxford, England), 1986, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Epinephrine; Humans; Hypotension, Orthostatic; Male; Nitroglycerin; Norepinephrin

1986

Other Studies

47 other studies available for nitroglycerin and Syncope

ArticleYear
Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2022, Volume: 32, Issue:3

    Topics: Diuretics; Female; Heart Arrest; Humans; Male; Nitroglycerin; Prevalence; Retrospective Studies; Syn

2022
The effects of ALDH2 Glu487Lys polymorphism on vasovagal syncope patients undergoing head-up tilt test supplemented with sublingual nitroglycerin.
    BMC cardiovascular disorders, 2022, 10-28, Volume: 22, Issue:1

    Topics: Aldehyde Dehydrogenase, Mitochondrial; Humans; Nitroglycerin; Polymorphism, Genetic; Syncope; Syncop

2022
The clinical presentation of syncope influences the head-up tilt test responses.
    European journal of internal medicine, 2023, Volume: 110

    Topics: Female; Humans; Male; Nitroglycerin; Retrospective Studies; Syncope; Syncope, Vasovagal; Tilt-Table

2023
Glyceryl trinitrate-induced blood pressure variability decrease during head-up tilt test predicts vasovagal response.
    Blood pressure monitoring, 2023, Oct-01, Volume: 28, Issue:5

    Topics: Blood Pressure; Heart Rate; Humans; Nitroglycerin; Syncope; Syncope, Vasovagal; Tilt-Table Test

2023
A higher proportion of men than of women fainted in the phase without nitroglycerin in tilt-induced vasovagal syncope.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020, Volume: 30, Issue:5

    Topics: Female; Humans; Male; Nitroglycerin; Retrospective Studies; Syncope; Syncope, Vasovagal; Tilt-Table

2020
Monitoring of cerebral oximetry during head-up tilt test in adults with history of syncope and orthostatic intolerance.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2018, 09-01, Volume: 20, Issue:9

    Topics: Adult; Aged; Arterial Pressure; Cerebrovascular Circulation; Female; Frontal Lobe; Humans; Hypotensi

2018
Chronic nitrate therapy reduces positivity rate of tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope.
    European journal of internal medicine, 2013, Volume: 24, Issue:6

    Topics: Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Multivariate Analysis; Nitrates; Nitrogl

2013
Poor diagnostic performance of tilt testing in hypertensive patients with unexplained syncope.
    Journal of human hypertension, 2014, Volume: 28, Issue:4

    Topics: Administration, Sublingual; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Autonomic Nervo

2014
A novel multi-parametric algorithm for faint prediction integrating indices of cardiac inotropy and vascular tone.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014, Volume: 2014

    Topics: Adult; Aged; Aged, 80 and over; Algorithms; Blood Pressure; Electrocardiography; Female; Heart Rate;

2014
Which hemodynamic parameter predicts nitroglycerin-potentiated head-up tilt test response?
    Pacing and clinical electrophysiology : PACE, 2015, Volume: 38, Issue:4

    Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Male; Nitroglycerin; Reproducibility of Results;

2015
[Hypertensive crisis: collapse after using nitro spray. For the elderly a low dose chew capsule is better!].
    MMW Fortschritte der Medizin, 2008, May-22, Volume: 150, Issue:21

    Topics: Administration, Sublingual; Aerosols; Dose-Response Relationship, Drug; Emergencies; Epistaxis; Fema

2008
Vasospasm-induced polymorphic ventricular tachycardia.
    The Canadian journal of cardiology, 2008, Volume: 24, Issue:12

    Topics: Angina Pectoris, Variant; Coronary Vasospasm; Echocardiography, Transesophageal; Electrocardiography

2008
Persistent atrial fibrillation associated with syncope due to orthostatic hypotension: a case report.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2009, Volume: 10, Issue:11

    Topics: Adult; Atrial Fibrillation; Bradycardia; Electric Countershock; Electrocardiography; Humans; Hypoten

2009
Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test.
    British journal of clinical pharmacology, 2011, Volume: 71, Issue:1

    Topics: Adult; Case-Control Studies; Electrocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Mi

2011
Effect of clinical triggers on positive responses to tilt-table testing potentiated with nitroglycerin or clomipramine.
    The American journal of cardiology, 2011, Jun-01, Volume: 107, Issue:11

    Topics: Aged; Clomipramine; Female; Humans; Male; Middle Aged; Nitroglycerin; Syncope; Tilt-Table Test; Vaso

2011
[Application of the head-up tilt table test in children under 6 years old].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2012, Volume: 14, Issue:4

    Topics: Age Factors; Blood Pressure; Child; Child, Preschool; Dizziness; Electrocardiography; Female; Humans

2012
[Estimation of head-up tilt test in diagnosis of syncope of unknown origin. Can we come up with better results?].
    Polskie Archiwum Medycyny Wewnetrznej, 2002, Volume: 108, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Case-Control Studies; Diagnosis, Differential; Evaluation Studies

2002
Simplified tilt table test protocol with continuous upright position during medication administration and no hydration.
    Pacing and clinical electrophysiology : PACE, 2003, Volume: 26, Issue:1P2

    Topics: Edrophonium; Fasting; Humans; Isoproterenol; Middle Aged; Nitroglycerin; Syncope; Tilt-Table Test

2003
Endogenous opioids and epinephrine in nitroglycerin provocation tilt test in patients with neurally mediated syncope.
    Japanese heart journal, 2003, Volume: 44, Issue:4

    Topics: Adolescent; Adult; Aged; Analysis of Variance; beta-Endorphin; Blood Pressure; Epinephrine; Female;

2003
[About listening the patient].
    Duodecim; laaketieteellinen aikakauskirja, 2003, Volume: 119, Issue:15

    Topics: Aged; Aged, 80 and over; Aortic Valve Stenosis; Coronary Artery Disease; Female; Humans; Nitroglycer

2003
The clinical utility and diagnostic value of the head-up tilt testing (HUT) protocol.
    Journal of cardiovascular electrophysiology, 2004, Volume: 15, Issue:5

    Topics: Humans; Nitroglycerin; Reproducibility of Results; Sensitivity and Specificity; Syncope; Tilt-Table

2004
Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: a review of 10 years' experience.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:11

    Topics: Aged; Blood Pressure; Chi-Square Distribution; Female; Humans; Male; Nitroglycerin; Syncope; Tilt-Ta

2004
[Estimation of autonomic nervous system tension in patients with syncope of unknown origin--traps in clinical interpretation results of heart rate variability].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2004, Volume: 16, Issue:95

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Autonomic Nervous System; Case-Control Studies; Evalu

2004
Late hemodynamic changes during a negative passive head-up tilt predict the symptomatic outcome to a nitroglycerin sensitized tilt.
    Pacing and clinical electrophysiology : PACE, 2005, Volume: 28, Issue:2

    Topics: Analysis of Variance; Blood Pressure; Cardiography, Impedance; Female; Heart Rate; Hemodynamics; Hum

2005
Effects of therapy based on tilt testing results on the long-term outcome in patients with syncope.
    Kardiologia polska, 2005, Volume: 63, Issue:7

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Female; Fludroco

2005
[Pseudosyncope and pseudoseizure].
    Orvosi hetilap, 2007, Jul-01, Volume: 148, Issue:26

    Topics: Dissociative Disorders; Electroencephalography; Female; Humans; Middle Aged; Nitroglycerin; Seizures

2007
Use of nitroglycerin in the active phase of tilt testing: is there a difference in elderly patients?
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2007, Volume: 26, Issue:4

    Topics: Age Factors; Aged; Female; Humans; Male; Middle Aged; Nitroglycerin; Prospective Studies; Syncope; T

2007
Tilt testing potentiated with sublingual nitroglycerin in children with unexplained syncope.
    European heart journal, 2007, Volume: 28, Issue:21

    Topics: Administration, Sublingual; Adolescent; Child; Child, Preschool; Female; Humans; Male; Nitroglycerin

2007
[Investigation in suspected syncope. A study of more than 1,174 consecutively referred patients].
    Ugeskrift for laeger, 2008, Feb-25, Volume: 170, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Nitroglycerin; Referr

2008
Tilt testing potentiated with sublingual nitroglycerin in children with unexplained syncope.
    European heart journal, 2008, Volume: 29, Issue:8

    Topics: Administration, Sublingual; Adolescent; Child; Child, Preschool; Humans; Nitroglycerin; Syncope; Til

2008
Carotid sinus hypersensitivity and syncope.
    Mayo Clinic proceedings, 1984, Volume: 59, Issue:9

    Topics: Aged; Atrioventricular Node; Cardiac Pacing, Artificial; Carotid Sinus; Electrophysiology; Humans; M

1984
[Syncope and chest pain. Demonstration of the mechanism by the hyperventilation test].
    Revista espanola de cardiologia, 1995, Volume: 48, Issue:9

    Topics: Chest Pain; Coronary Angiography; Coronary Vasospasm; Electrocardiography; Humans; Hyperventilation;

1995
Value of head-up tilt testing potentiated with sublingual nitroglycerin to assess the origin of unexplained syncope.
    The American journal of cardiology, 1995, Aug-01, Volume: 76, Issue:4

    Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Child; Evalu

1995
Transient reversal of blood flow in an internal thoracic artery to coronary artery graft during syncope.
    Clinical cardiology, 1994, Volume: 17, Issue:8

    Topics: Coronary Artery Bypass; Coronary Circulation; Heart Bypass, Right; Humans; Male; Middle Aged; Nitrog

1994
Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope.
    American heart journal, 1994, Volume: 127, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Case-Control Studies; Female; Heart Rate; Humans; Is

1994
Therapy of angina pectoris with long-acting nitrates: which agent and when?
    The Canadian journal of cardiology, 1996, Volume: 12 Suppl C

    Topics: Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Tolerance; Head

1996
Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope.
    American heart journal, 1998, Volume: 135, Issue:4

    Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Diagnosis, D

1998
Worsening of head-up tilt test response during chronic beta-blocker therapy in patients treated for neurally mediated syncope.
    Giornale italiano di cardiologia, 1998, Volume: 28, Issue:8

    Topics: Adrenergic beta-Antagonists; Adult; Chronic Disease; Female; Follow-Up Studies; Heart Arrest; Humans

1998
Reproducibility of head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope.
    The American journal of cardiology, 1999, Aug-01, Volume: 84, Issue:3

    Topics: Administration, Sublingual; Adolescent; Adult; Aged; Child; Diagnosis, Differential; Female; Humans;

1999
Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action.
    Pacing and clinical electrophysiology : PACE, 2002, Volume: 25, Issue:5

    Topics: Adult; Baroreflex; Blood Pressure; Blood Pressure Determination; Bradycardia; Electrocardiography; H

2002
Adverse reactions to local anaesthetics and vasoconstrictor drugs.
    The Practitioner, 1975, Volume: 214, Issue:1281

    Topics: Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Arteriosclerosis; Blood Pressure; Coronary Dise

1975
Defining the proper role for self-administered sublingual nitroglycerin. A survey of physicians and patients.
    Chest, 1991, Volume: 100, Issue:1

    Topics: Administration, Sublingual; Aged; Attitude; Attitude of Health Personnel; Bradycardia; Data Collecti

1991
Vasodilator therapy-induced pacemaker syndrome.
    Chest, 1987, Volume: 91, Issue:6

    Topics: Humans; Hypotension; Male; Middle Aged; Nifedipine; Nitroglycerin; Pacemaker, Artificial; Syncope; S

1987
[Old age and antihypertensive therapy--causes of nitroglycerin-induced syncope].
    Lakartidningen, 1988, Dec-14, Volume: 85, Issue:50

    Topics: Age Factors; Aged; Antihypertensive Agents; Female; Humans; Male; Middle Aged; Nitroglycerin; Syncop

1988
Symptomatic prognosis in patients with idiopathic hypertrophic subaortic stenosis (IHSS).
    The American journal of medicine, 1973, Volume: 55, Issue:1

    Topics: Administration, Oral; Adolescent; Aged; Angina Pectoris; Blood Pressure; Cardiac Catheterization; Ca

1973
[On the chronic poisoning by nitrated compounds in the workers of explosive factories].
    La Presse medicale, 1969, Apr-26, Volume: 77, Issue:21

    Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Electrocardiography; Female; Heart Rate; Humans; Hyp

1969
[Conservative therapy of angina pectoris].
    Schweizerische medizinische Wochenschrift, 1970, May-16, Volume: 100, Issue:20

    Topics: Acute Disease; Amyl Nitrite; Angina Pectoris; Anticoagulants; Coronary Disease; Digitalis Glycosides

1970