nitroglycerin has been researched along with Subarachnoid Hemorrhage in 20 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Controlled hypotension with nitroglycerin has been used n 30 neurosurgical procedures for aneurysms clipping, artero-veinous malformations, cerebral vascularised tumours and in some cases in the course of serial carotido-cerebral angiography." | 7.66 | [Controlled hypotension with nitroglycerin in neurosurgery (author's transl)]. ( Benech, F; Liboni, W; Lo Russo, G; Urciuoli, R, 1980) |
| "Nitroglycerin was used in a target dose of 14 microg/kg/h." | 6.71 | Transdermal nitroglycerin in patients with subarachnoid hemorrhage. ( Andres, R; Barth, L; Ozdoba, C; Reinert, M; Seiler, R; Wiest, R, 2004) |
| "In the rabbit subarachnoid hemorrhage (SAH) model, the sensitivity of spastic basilar arteries to nitric oxide (NO) was enhanced whereas the endothelial function to release/produce NO became impaired, as described previously." | 5.31 | Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. ( Azuma, H; Hirakawa, K; Isotani, E; Ito, Y; Mizuno, Y, 2000) |
| "Controlled hypotension with nitroglycerin has been used n 30 neurosurgical procedures for aneurysms clipping, artero-veinous malformations, cerebral vascularised tumours and in some cases in the course of serial carotido-cerebral angiography." | 3.66 | [Controlled hypotension with nitroglycerin in neurosurgery (author's transl)]. ( Benech, F; Liboni, W; Lo Russo, G; Urciuoli, R, 1980) |
| "Nitroglycerin was used in a target dose of 14 microg/kg/h." | 2.71 | Transdermal nitroglycerin in patients with subarachnoid hemorrhage. ( Andres, R; Barth, L; Ozdoba, C; Reinert, M; Seiler, R; Wiest, R, 2004) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| "Patients with cerebral vasospasm caused by aneurysmal subarachnoid hemorrhage (aSAH) are often treated with intra-arterial (IA) vasodilator infusion." | 1.62 | Use of single versus multiple vasodilator agents in the treatment of cerebral vasospasm: is more better than less? ( Bulsara, K; Chen, PR; Day, AL; Erkmen, K; Kim, DH; Lopez-Rivera, V; Oni-Orisan, AO; Sanzgiri, A; Sheriff, FG; Sheth, S; Vahidy, FS, 2021) |
| "Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a major cause of high morbidity and mortality." | 1.37 | Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. ( Fandino, J; Fathi, AR; Graupner, T; Jakob, SM; Marbacher, S; Schroth, G; Wehrli, F, 2011) |
| "In the rabbit subarachnoid hemorrhage (SAH) model, the sensitivity of spastic basilar arteries to nitric oxide (NO) was enhanced whereas the endothelial function to release/produce NO became impaired, as described previously." | 1.31 | Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. ( Azuma, H; Hirakawa, K; Isotani, E; Ito, Y; Mizuno, Y, 2000) |
| "To investigate the effects of subarachnoid hemorrhage (SAH) on the responsiveness of human cerebral arteries to vasoactive substances, the authors measured the isometric tension generated in helical strips of basilar and middle cerebral arteries isolated from human cadavers." | 1.29 | Altered reactivity of human cerebral arteries after subarachnoid hemorrhage. ( Abe, T; Akiyama, M; Kaito, N; Onoue, H; Tokudome, S; Tomii, M, 1995) |
| "The effects of intravenous nitroglycerin (NTG) combined with dopamine on intracranial pressure (ICP) and cerebral arteriovenous oxygen difference (AVDO2) were studied in 11 patients with acute subarachnoid haemorrhage (SAH)." | 1.29 | Effects of intravenous nitroglycerin combined with dopamine on intracranial pressure and cerebral arteriovenous oxygen difference in patients with acute subarachnoid haemorrhage. ( Aoki, H; Boku, E; Goda, K; Imanishi, M; Iwanaga, H; Koshimae, N; Okuchi, K; Sakaki, T; Tokunaga, H, 1995) |
| "Especially in patients with severe subarachnoid hemorrhage classified as CT group 3 or 4, symptomatic vasospasm occurred in 11 patients (30." | 1.28 | [Clinical effect of nitroglycerin (GTN) on prevention of cerebral vasospasm]. ( Goto, T; Ogayama, H; Sasaki, J; Sasanuma, J; Watanabe, K, 1991) |
| "These results suggest that subarachnoid hemorrhage influences both the generation of EDRF and the constriction of affected arteries." | 1.28 | Pharmacological studies on relaxation of spastic primate cerebral arteries in subarachnoid hemorrhage. ( Cook, DA; Findlay, JM; Kanamaru, K; Krueger, CA; Weir, BK, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, PR | 1 |
| Bulsara, K | 1 |
| Lopez-Rivera, V | 1 |
| Sheriff, FG | 1 |
| Sanzgiri, A | 1 |
| Sheth, S | 1 |
| Oni-Orisan, AO | 1 |
| Vahidy, FS | 1 |
| Erkmen, K | 1 |
| Kim, DH | 1 |
| Day, AL | 1 |
| Fathi, AR | 1 |
| Marbacher, S | 2 |
| Graupner, T | 2 |
| Wehrli, F | 1 |
| Jakob, SM | 2 |
| Schroth, G | 1 |
| Fandino, J | 2 |
| Castriota, F | 1 |
| Cremonesi, A | 1 |
| Manetti, R | 1 |
| Liso, A | 1 |
| Oshola, K | 1 |
| Ricci, E | 1 |
| Balestra, G | 1 |
| Reinert, M | 1 |
| Wiest, R | 1 |
| Barth, L | 1 |
| Andres, R | 1 |
| Ozdoba, C | 1 |
| Seiler, R | 1 |
| Ziliene, V | 1 |
| Neuschmelting, V | 1 |
| Pluta, RM | 1 |
| Artru, F | 1 |
| Philippon, B | 1 |
| Poussel, JF | 1 |
| Montarry, M | 1 |
| Deleuze, R | 1 |
| Farelli, S | 1 |
| Mazzone, P | 1 |
| Robbiano, F | 1 |
| Turco, M | 1 |
| Urciuoli, R | 1 |
| Benech, F | 1 |
| Liboni, W | 1 |
| Lo Russo, G | 1 |
| Frazee, JG | 1 |
| Giannotta, SL | 1 |
| Stern, WE | 1 |
| Onoue, H | 1 |
| Kaito, N | 1 |
| Akiyama, M | 1 |
| Tomii, M | 1 |
| Tokudome, S | 1 |
| Abe, T | 1 |
| Sutter, B | 1 |
| Suzuki, S | 1 |
| Arthur, AS | 1 |
| Kassell, NF | 1 |
| Lee, KS | 1 |
| Iwanaga, H | 2 |
| Okuchi, K | 1 |
| Koshimae, N | 1 |
| Goda, K | 1 |
| Imanishi, M | 1 |
| Tokunaga, H | 1 |
| Aoki, H | 1 |
| Boku, E | 1 |
| Sakaki, T | 1 |
| Nakao, K | 1 |
| Murata, H | 1 |
| Kanamaru, K | 2 |
| Waga, S | 1 |
| Ito, Y | 1 |
| Isotani, E | 1 |
| Mizuno, Y | 1 |
| Azuma, H | 1 |
| Hirakawa, K | 1 |
| Abe, K | 1 |
| Yoshiya, I | 1 |
| Sasanuma, J | 1 |
| Goto, T | 1 |
| Ogayama, H | 1 |
| Sasaki, J | 1 |
| Watanabe, K | 1 |
| Weir, BK | 1 |
| Findlay, JM | 1 |
| Krueger, CA | 1 |
| Cook, DA | 1 |
| Poletti, CE | 1 |
| Wepsic, JG | 1 |
| Sweet, WH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury[NCT04951453] | 150 participants (Actual) | Observational | 2021-08-18 | Active, not recruiting | |||
| Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage[NCT05686265] | 32 participants (Anticipated) | Observational | 2023-05-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitroglycerin and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
2 trials available for nitroglycerin and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Transdermal nitroglycerin in patients with subarachnoid hemorrhage.
Topics: Administration, Cutaneous; Blood Flow Velocity; Blood Pressure; Brain Mapping; Cerebrovascular Circu | 2004 |
Carbon dioxide reactivity and local cerebral blood flow during prostaglandin E1- or nitroglycerin-induced hypotension.
Topics: Adult; Aged; Alprostadil; Anesthesia, Inhalation; Blood Pressure; Carbon Dioxide; Cerebrovascular Ci | 1992 |
16 other studies available for nitroglycerin and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Use of single versus multiple vasodilator agents in the treatment of cerebral vasospasm: is more better than less?
Topics: Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nicardipine; Nitroglycerin; Retrospect | 2021 |
Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo.
Topics: Animals; Disease Models, Animal; Injections, Spinal; Intracranial Aneurysm; Male; Nitroglycerin; Rab | 2011 |
Impact of cerebral protection devices on early outcome of carotid stenting.
Topics: Aged; Blood Vessel Prosthesis Implantation; Carotid Artery, Common; Carotid Stenosis; Cerebrovascula | 2002 |
Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo.
Topics: Animals; Basilar Artery; Cerebral Angiography; Female; Injections, Spinal; Male; Nimodipine; Nitric | 2008 |
[Effects of intravenous nitroglycerin on blood pressure, intracranial pressure and total and regional cerebral blood flow in cases of subarachnoid hemorrhage with vasospasm].
Topics: Blood Pressure; Cerebrovascular Circulation; Humans; Intracranial Aneurysm; Intracranial Pressure; I | 1984 |
[Intraoperative controlled hypotension using nitroglycerine].
Topics: Anesthesia, General; Drug Evaluation; Female; Humans; Hypotension, Controlled; Intracranial Arteriov | 1984 |
[Controlled hypotension with nitroglycerin in neurosurgery (author's transl)].
Topics: Adult; Humans; Hypotension; Intracranial Pressure; Intraoperative Complications; Ischemic Attack, Tr | 1980 |
Intravenous nitroglycerin for the treatment of chronic cerebral vasoconstriction in the primate.
Topics: Animals; Brain; Female; Injections, Intravenous; Macaca mulatta; Macaca nemestrina; Male; Nitroglyce | 1981 |
Altered reactivity of human cerebral arteries after subarachnoid hemorrhage.
Topics: Adult; Aged; Analysis of Variance; Bradykinin; Cerebral Arteries; Dinoprost; Epoprostenol; Female; H | 1995 |
Effects of subarachnoid hemorrhage on vascular responses to calcitonin gene-related peptide and its related second messengers.
Topics: Analysis of Variance; Animals; Basilar Artery; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AM | 1995 |
Effects of intravenous nitroglycerin combined with dopamine on intracranial pressure and cerebral arteriovenous oxygen difference in patients with acute subarachnoid haemorrhage.
Topics: Adult; Aged; Brain; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; H | 1995 |
Effects of nitroglycerin on vasospasm and cyclic nucleotides in a primate model of subarachnoid hemorrhage.
Topics: Animals; Blood Pressure; Cerebral Angiography; Cerebral Arteries; Cerebral Cortex; Cerebrovascular C | 1996 |
Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin.
Topics: Administration, Cutaneous; Animals; Basilar Artery; Coronary Angiography; Hemodynamics; In Vitro Tec | 2000 |
[Clinical effect of nitroglycerin (GTN) on prevention of cerebral vasospasm].
Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Female; Humans; Intracranial Aneurysm; Ischemic Att | 1991 |
Pharmacological studies on relaxation of spastic primate cerebral arteries in subarachnoid hemorrhage.
Topics: Acetylcholine; Animals; Calcimycin; Cerebral Angiography; Cerebral Arteries; Endothelium, Vascular; | 1989 |
Middle cerebral arterial spasm from subarachnoid blood: spasmolysis with topical use of nitroglycerin.
Topics: Animals; Cerebral Arterial Diseases; Dogs; Ischemic Attack, Transient; Nitroglycerin; Subarachnoid H | 1972 |