nitroglycerin has been researched along with Stroke in 57 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Some studies have suggested that transdermal administration of glyceryl trinitrate (GTN; nitroglycerin) in the first few hours after symptom onset increases the chance of a favourable outcome after ischaemic stroke or intracerebral haemorrhage, possibly through an increase in intracranial collateral blood flow and a reduction in blood pressure." | 9.30 | Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial. ( Caminada, K; de Leeuw, FE; Dippel, DWJ; Fransen, PSS; Hofmeijer, J; Kerkhoff, H; Kruyt, ND; Nederkoorn, PJ; Siegers, A; van den Berg, SA; van der Worp, HB, 2019) |
| "There is currently insufficient evidence to recommend the use of NO donors, L-arginine or NOS-I in acute stroke, and only one drug (GTN) has been assessed." | 8.95 | Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. ( Appleton, JP; Bath, PM; Krishnan, K, 2017) |
| "The study was conducted to test the hypothesis that nitroglycerin (NTG) increases cerebral perfusion focally and globally in acute ischemic stroke patients, using serial perfusion-weighted imaging (PWI) magnetic resonance imaging measurements." | 8.02 | Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke. ( Asdaghi, N; Beaulieu, C; Buck, B; Butcher, K; Emery, D; Gioia, L; Jeerakathil, T; Kate, M; Shuaib, A, 2021) |
| "Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke." | 7.88 | Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. ( Bix, GJ; Fraser, JF; Gorman, A; Learoyd, AE; Maniskas, ME; Roberts, JM; Trueman, R, 2018) |
| "Pooled analyses of previous randomised studies have suggested that very early treatment with glyceryl trinitrate (also known as nitroglycerin) improves functional outcome in patients with acute ischaemic stroke or intracerebral haemorrhage, but this finding was not confirmed in a more recent trial (RIGHT-2)." | 5.51 | Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial. ( Berkhemer, OA; Boomars, R; Boomsma, JMF; Caminada, K; de Leeuw, FE; Dippel, DWJ; Emmer, BJ; Esteve Cuevas, LM; Fransen, PSS; Hofmeijer, J; Kerkhoff, H; Kwa, VIH; Lingsma, HF; Lok, T; Majoie, CBLM; Miedema, I; Nederkoorn, PJ; Nieboer, D; O Pruissen, DM; Raaijmakers, TWM; Reinink, H; Roos, YBWEM; Schipper, MH; Schonewille, WJ; Siegers, A; Uniken Venema, SM; van 't Net, A; van den Berg, SA; van der Lugt, A; van der Worp, HB; van Dijk, GW; van Eijkelenburg, RPJ; van Oostenbrugge, RJ; van Vliet, JA; Visser, MC; Zwetsloot, CP, 2022) |
| "Transient focal ischemia caused by middle cerebral artery occlusion (MCAo) produces apoptotic cell death in the penumbra area." | 5.34 | Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression. ( Amantea, D; Bagetta, G; Blandini, F; Corasaniti, MT; Greco, R; Nappi, G; Tassorelli, C, 2007) |
| "Background and Purpose- Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset." | 5.30 | Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data From the RIGHT-2 Trial. ( Anderson, CS; Appleton, JP; Bath, PM; Berge, E; Cala, L; Dixon, M; England, TJ; Godolphin, PJ; Hepburn, T; Krishnan, K; Mair, G; Montgomery, AA; Phillips, SJ; Potter, J; Price, CI; Randall, M; Robinson, TG; Roffe, C; Rothwell, PM; Sandset, EC; Sanossian, N; Saver, JL; Siriwardena, AN; Sprigg, N; Venables, G; Wardlaw, JM; Woodhouse, LJ, 2019) |
| "Some studies have suggested that transdermal administration of glyceryl trinitrate (GTN; nitroglycerin) in the first few hours after symptom onset increases the chance of a favourable outcome after ischaemic stroke or intracerebral haemorrhage, possibly through an increase in intracranial collateral blood flow and a reduction in blood pressure." | 5.30 | Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial. ( Caminada, K; de Leeuw, FE; Dippel, DWJ; Fransen, PSS; Hofmeijer, J; Kerkhoff, H; Kruyt, ND; Nederkoorn, PJ; Siegers, A; van den Berg, SA; van der Worp, HB, 2019) |
| "There is currently insufficient evidence to recommend the use of NO donors, L-arginine or NOS-I in acute stroke, and only one drug (GTN) has been assessed." | 4.95 | Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. ( Appleton, JP; Bath, PM; Krishnan, K, 2017) |
| "The study was conducted to test the hypothesis that nitroglycerin (NTG) increases cerebral perfusion focally and globally in acute ischemic stroke patients, using serial perfusion-weighted imaging (PWI) magnetic resonance imaging measurements." | 4.02 | Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke. ( Asdaghi, N; Beaulieu, C; Buck, B; Butcher, K; Emery, D; Gioia, L; Jeerakathil, T; Kate, M; Shuaib, A, 2021) |
| "Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke." | 3.88 | Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. ( Bix, GJ; Fraser, JF; Gorman, A; Learoyd, AE; Maniskas, ME; Roberts, JM; Trueman, R, 2018) |
| "High blood pressure is common in acute stroke and associated with a worse functional outcome." | 2.90 | Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial. ( Appleton, JP; Bath, PM; Dixon, M; Scutt, P; Sprigg, N; Wardlaw, JM; Woodhouse, LJ, 2019) |
| "High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable results, and the management of high blood pressure in ultra-acute stroke remains unclear." | 2.90 | Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. ( , 2019) |
| "Post-stroke dysphagia is common, associated with poor outcome and often requires non-oral feeding/fluids." | 2.87 | Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial. ( Bath, PM; Bereczki, D; Berge, E; Bladin, CF; Caso, V; Christensen, HK; Cohen, DL; Collins, R; Czlonkowska, A; de Silva, A; Etribi, A; Hamdy, S; Laska, AC; Ntaios, G; Ozturk, S; Phillips, SJ; Prasad, K; Roffe, C; Scutt, P; Smithard, DG; Sprigg, N; Szatmari, S; Woodhouse, LJ, 2018) |
| "Inhalation of NO at 80 ppm for 4 h in STEMI was safe but did not reduce infarct size relative to absolute LVmass at 48-72h." | 2.87 | Nitric oxide for inhalation in ST-elevation myocardial infarction (NOMI): a multicentre, double-blind, randomized controlled trial. ( Adriaenssens, T; Belmans, A; Bennett, J; Bloch, KD; Bogaert, J; Claus, P; Desmet, W; Dubois, C; Durak, M; Goetschalckx, K; Janssens, SP; Lech, P; Lux, A; Merkely, B; Pokreisz, P; Sinnaeve, P; Szelid, Z; Toth, A; Van de Werf, F; Vandenberghe, K; Vermeersch, P; Vranckx, P; Zalewski, J; Zmudka, K, 2018) |
| "Central adjudication of serious adverse events (SAEs) can be undertaken in clinical trials, especially for open-label studies where outcome assessment may be at risk of bias." | 2.87 | Central adjudication of serious adverse events did not affect trial's safety results: Data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial. ( Bath, PM; Bereczki, D; Berge, E; Collins, R; Díez-Tejedor, E; Godolphin, PJ; Gommans, J; Lees, KR; Montgomery, AA; Ozturk, S; Phillips, S; Pocock, S; Prasad, K; Sprigg, N; Szatmari, S; Wang, Y; Woodhouse, LJ, 2018) |
| "Infections were associated with an increased risk of death (p < 0." | 2.84 | Infections Up to 76 Days After Stroke Increase Disability and Death. ( Bath, PM; Bereczki, D; Berge, E; Caso, V; Christensen, H; Collins, R; Czlonkowska, A; El Etribi, A; Farr, TD; Fone, KC; Gommans, J; Laska, AC; Learoyd, AE; Ntaios, G; Ozturk, S; Pocock, SJ; Prasad, K; Shaw, L; Sprigg, N; Trueman, RC; Wardlaw, JM; Woodhouse, L, 2017) |
| " Safety outcomes were adverse events." | 2.82 | Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta-analysis of randomized trials. ( Chan, WL; Lee, WF; Lim, BL; Loo, KV; Man Goh, CJ; Ng, WM; Situ, W, 2022) |
| "In patients with intracerebral hemorrhage within 48 hours of onset, GTN lowered blood pressure was safe but did not improve functional outcome." | 2.82 | Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. ( Adami, A; Bath, PM; Becker, JL; Berge, E; Cala, LA; Casado, AM; Caso, V; Chen, C; Christensen, H; Collins, R; Czlonkowska, A; de Silva, A; Dineen, RA; Gommans, J; Koumellis, P; Krishnan, K; Lees, KR; Ntaios, G; Ozturk, S; Phillips, SJ; Pocock, SJ; Scutt, P; Sprigg, N; Szatmari, S; Wardlaw, JM; Woodhouse, L, 2016) |
| "High blood pressure is associated with poor outcome after stroke." | 2.80 | Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. ( , 2015) |
| "Nitric oxide donors are candidate treatments for acute stroke, potentially through hemodynamic, reperfusion, and neuroprotectant effects, especially if given early." | 2.80 | Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial. ( Bath, PM; Berge, E; Gommans, J; Krishnan, K; Ntaios, G; Scutt, P; Sprigg, N; Wardlaw, J; Woodhouse, L, 2015) |
| "High blood pressure is common during the acute phase of stroke and is associated with a poor outcome." | 2.79 | Statistical analysis plan for the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial. ( Bath, PM; Houlton, A; Pocock, S; Sprigg, N; Wardlaw, J; Woodhouse, L, 2014) |
| "15), and serious adverse events, 14 (56%) versus 10 (63%; P=0." | 2.78 | Feasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the rapid intervention with glyceryl trinitrate in Hypertensive Stroke Trial (RIGHT, ISRCTN66434824). ( Ankolekar, S; Bath, PM; Cox, P; Cross, I; Fuller, M; Renton, C; Siriwardena, AN; Sprigg, N, 2013) |
| "High blood pressure is a common complication in acute stroke and is associated with a poor outcome." | 2.76 | The effect of transdermal glyceryl trinitrate on 24 h ambulatory blood pressure in acute/subacute stroke. ( Bath, AJ; Bath, PM; Geeganage, CM, 2011) |
| "Many patients with acute stroke are taking antihypertensive medications." | 2.72 | Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122). ( , 2006) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| " Safety outcomes include reported adverse events." | 1.62 | Benefits and safety of transdermal glyceryl trinitrate in acute stroke: a systematic review and meta-analysis of randomised trials (protocol). ( Chan, WL; Lee, WF; Lim, BL; Ng, WM; Tay, WL, 2021) |
| "In all participants and those with lacunar syndrome (LACS; 1,397, 34." | 1.56 | Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke. ( Adami, A; Appleton, JP; Bath, PM; Becker, JL; Berge, E; Cala, LA; Casado, AM; Caso, V; Christensen, HK; Dineen, RA; Gommans, J; Koumellis, P; Sprigg, N; Szatmari, S; Wardlaw, JM; Woodhouse, LJ, 2020) |
| "Microvascular coronary dysfunction (MCD) in women with no obstructive CAD portends an adverse prognosis of a 2." | 1.38 | Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. ( Anderson, RD; Azarbal, B; Handberg, E; Johnson, BD; Kar, S; Kelsey, SF; Kothawade, K; Lerman, A; Mehta, PK; Merz, CN; Pepine, CJ; Petersen, J; Samuels, B; Sharaf, B; Shaw, L; Shufelt, C; Sopko, G; Wei, J, 2012) |
| "Transient focal ischemia caused by middle cerebral artery occlusion (MCAo) produces apoptotic cell death in the penumbra area." | 1.34 | Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression. ( Amantea, D; Bagetta, G; Blandini, F; Corasaniti, MT; Greco, R; Nappi, G; Tassorelli, C, 2007) |
| "These findings demonstrate that NO bioavailability is reduced in hypertensive subjects with familial history of stroke." | 1.33 | Nitric oxide release is impaired in hypertensive individuals with familial history of stroke. ( Balla, C; Cosentino, F; De Luca, N; De Sensi, F; De Siati, L; Francia, P; Musumeci, B; Rao, MA; Volpe, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.75) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (26.32) | 29.6817 |
| 2010's | 31 (54.39) | 24.3611 |
| 2020's | 10 (17.54) | 2.80 |
| Authors | Studies |
|---|---|
| Lim, BL | 2 |
| Lee, WF | 2 |
| Ng, WM | 2 |
| Situ, W | 1 |
| Loo, KV | 1 |
| Man Goh, CJ | 1 |
| Chan, WL | 2 |
| Tunnage, B | 1 |
| Woodhouse, LJ | 13 |
| Dixon, M | 7 |
| Anderson, C | 1 |
| Ankolekar, S | 2 |
| Appleton, J | 1 |
| Cala, L | 2 |
| England, T | 2 |
| Krishnan, K | 9 |
| Havard, D | 5 |
| Mair, G | 2 |
| Muir, K | 1 |
| Phillips, S | 4 |
| Potter, J | 2 |
| Price, C | 1 |
| Randall, M | 2 |
| Robinson, TG | 2 |
| Roffe, C | 3 |
| Sandset, E | 1 |
| Siriwardena, N | 1 |
| Scutt, P | 10 |
| Wardlaw, JM | 10 |
| Sprigg, N | 18 |
| Bath, PM | 27 |
| van den Berg, SA | 2 |
| Uniken Venema, SM | 1 |
| Reinink, H | 1 |
| Hofmeijer, J | 2 |
| Schonewille, WJ | 1 |
| Miedema, I | 1 |
| Fransen, PSS | 2 |
| O Pruissen, DM | 1 |
| Raaijmakers, TWM | 1 |
| van Dijk, GW | 1 |
| de Leeuw, FE | 2 |
| van Vliet, JA | 1 |
| Kwa, VIH | 1 |
| Kerkhoff, H | 2 |
| van 't Net, A | 1 |
| Boomars, R | 1 |
| Siegers, A | 2 |
| Lok, T | 1 |
| Caminada, K | 2 |
| Esteve Cuevas, LM | 1 |
| Visser, MC | 1 |
| Zwetsloot, CP | 1 |
| Boomsma, JMF | 1 |
| Schipper, MH | 1 |
| van Eijkelenburg, RPJ | 1 |
| Berkhemer, OA | 1 |
| Nieboer, D | 1 |
| Lingsma, HF | 1 |
| Emmer, BJ | 1 |
| van Oostenbrugge, RJ | 1 |
| van der Lugt, A | 1 |
| Roos, YBWEM | 1 |
| Majoie, CBLM | 1 |
| Dippel, DWJ | 2 |
| Nederkoorn, PJ | 2 |
| van der Worp, HB | 2 |
| Law, ZK | 1 |
| Dineen, RA | 4 |
| Gao, J | 1 |
| Cheng, Z | 1 |
| Jiang, S | 1 |
| Wills, M | 1 |
| Wehbe, A | 1 |
| Rajah, GB | 1 |
| Geng, X | 1 |
| Ding, Y | 1 |
| Appleton, JP | 13 |
| Haywood, LJ | 3 |
| Williams, J | 3 |
| Siriwardena, AN | 5 |
| Anderson, CS | 1 |
| Berge, E | 10 |
| England, TJ | 1 |
| Godolphin, PJ | 2 |
| Hepburn, T | 2 |
| Montgomery, AA | 3 |
| Phillips, SJ | 4 |
| Price, CI | 1 |
| Rothwell, PM | 3 |
| Sandset, EC | 2 |
| Sanossian, N | 1 |
| Saver, JL | 1 |
| Venables, G | 1 |
| Adami, A | 3 |
| Becker, JL | 3 |
| Cala, LA | 3 |
| Casado, AM | 3 |
| Caso, V | 4 |
| Christensen, HK | 3 |
| Gommans, J | 8 |
| Koumellis, P | 3 |
| Szatmari, S | 6 |
| Kate, M | 1 |
| Gioia, L | 1 |
| Asdaghi, N | 1 |
| Jeerakathil, T | 1 |
| Shuaib, A | 1 |
| Buck, B | 1 |
| Emery, D | 1 |
| Beaulieu, C | 1 |
| Butcher, K | 1 |
| Tay, WL | 1 |
| Learoyd, AE | 2 |
| Woodhouse, L | 5 |
| Shaw, L | 2 |
| Bereczki, D | 4 |
| Christensen, H | 4 |
| Collins, R | 6 |
| Czlonkowska, A | 4 |
| El Etribi, A | 1 |
| Farr, TD | 1 |
| Laska, AC | 2 |
| Ntaios, G | 7 |
| Ozturk, S | 6 |
| Pocock, SJ | 2 |
| Prasad, K | 3 |
| Fone, KC | 1 |
| Trueman, RC | 1 |
| Howard, H | 1 |
| Haywood, L | 1 |
| Pocock, S | 4 |
| Hamdy, S | 1 |
| Smithard, DG | 1 |
| Cohen, DL | 1 |
| Bladin, CF | 1 |
| de Silva, A | 2 |
| Etribi, A | 1 |
| Janssens, SP | 1 |
| Bogaert, J | 1 |
| Zalewski, J | 1 |
| Toth, A | 1 |
| Adriaenssens, T | 1 |
| Belmans, A | 1 |
| Bennett, J | 1 |
| Claus, P | 1 |
| Desmet, W | 1 |
| Dubois, C | 1 |
| Goetschalckx, K | 1 |
| Sinnaeve, P | 1 |
| Vandenberghe, K | 1 |
| Vermeersch, P | 1 |
| Lux, A | 1 |
| Szelid, Z | 1 |
| Durak, M | 1 |
| Lech, P | 1 |
| Zmudka, K | 1 |
| Pokreisz, P | 1 |
| Vranckx, P | 1 |
| Merkely, B | 1 |
| Bloch, KD | 1 |
| Van de Werf, F | 1 |
| Billington, CK | 1 |
| Glover, M | 1 |
| Bath, PMW | 1 |
| Díez-Tejedor, E | 1 |
| Lees, KR | 3 |
| Wang, Y | 1 |
| Johnston, KC | 1 |
| Durkalski-Mauldin, VL | 1 |
| Kruyt, ND | 1 |
| Fuller, M | 1 |
| Cross, I | 1 |
| Renton, C | 1 |
| Cox, P | 1 |
| Houlton, A | 1 |
| Wardlaw, J | 4 |
| Hankey, GJ | 1 |
| Koziolek, MJ | 1 |
| Lüders, S | 1 |
| Lyakishev, AA | 1 |
| Chen, C | 3 |
| Maniskas, ME | 1 |
| Roberts, JM | 1 |
| Trueman, R | 1 |
| Gorman, A | 1 |
| Fraser, JF | 1 |
| Bix, GJ | 1 |
| Sare, GM | 1 |
| Gray, LJ | 1 |
| Kuhlmann, U | 1 |
| Hoyer, J | 1 |
| Heidenreich, S | 1 |
| Holzgreve, H | 1 |
| Geeganage, CM | 1 |
| Bath, AJ | 1 |
| Wei, J | 1 |
| Mehta, PK | 1 |
| Johnson, BD | 1 |
| Samuels, B | 1 |
| Kar, S | 1 |
| Anderson, RD | 1 |
| Azarbal, B | 1 |
| Petersen, J | 1 |
| Sharaf, B | 1 |
| Handberg, E | 1 |
| Shufelt, C | 1 |
| Kothawade, K | 1 |
| Sopko, G | 1 |
| Lerman, A | 1 |
| Kelsey, SF | 1 |
| Pepine, CJ | 1 |
| Merz, CN | 1 |
| Gubitz, G | 1 |
| Willmot, M | 2 |
| Bath, P | 1 |
| Castriota, F | 1 |
| Cremonesi, A | 1 |
| Manetti, R | 1 |
| Liso, A | 1 |
| Oshola, K | 1 |
| Ricci, E | 1 |
| Balestra, G | 1 |
| HOHNEN, HW | 1 |
| MEESE, T | 1 |
| Ziliene, V | 1 |
| Sun, H | 1 |
| Zheng, H | 1 |
| Molacek, E | 1 |
| Fang, Q | 1 |
| Patel, KP | 1 |
| Mayhan, WG | 1 |
| Ghadami, A | 1 |
| Whysall, B | 1 |
| Clarke, W | 1 |
| Lavallée, PC | 1 |
| Bonnin, P | 1 |
| Labreuche, J | 1 |
| Amarenco, P | 1 |
| Lévy, B | 1 |
| Cosentino, F | 1 |
| Francia, P | 1 |
| Musumeci, B | 1 |
| De Siati, L | 1 |
| Rao, MA | 1 |
| De Luca, N | 1 |
| Balla, C | 1 |
| De Sensi, F | 1 |
| Volpe, M | 1 |
| Greco, R | 1 |
| Amantea, D | 1 |
| Blandini, F | 1 |
| Nappi, G | 1 |
| Bagetta, G | 1 |
| Corasaniti, MT | 1 |
| Tassorelli, C | 1 |
| Rigatelli, G | 1 |
| Dell'avvocata, F | 1 |
| Cardaioli, P | 1 |
| Pathansali, R | 1 |
| Iddenden, R | 1 |
| Bath, FJ | 1 |
| Kanji, S | 1 |
| Corman, C | 1 |
| Douen, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Collaborative, International, Multicentre, Randomised, Parallel-group, Single and Outcome Blinded, Controlled, Factorial Trial to Investigate the Safety and Efficacy of Treatment With Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, a[NCT00989716] | Phase 3 | 3,500 participants (Anticipated) | Interventional | 2001-07-31 | Recruiting | ||
| The Effects of Nitric Oxide for Inhalation on Myocardial Infarction Size[NCT01398384] | Phase 2 | 250 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235] | Phase 2 | 60 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction[NCT00832702] | 433 participants (Anticipated) | Observational | 2008-09-17 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for nitroglycerin and Stroke
| Article | Year |
|---|---|
Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta-analysis of randomized trials.
Topics: Cerebral Hemorrhage; Humans; Ischemic Stroke; Nitroglycerin; Randomized Controlled Trials as Topic; | 2022 |
Transdermal delivery of glyceryl trinitrate: clinical applications in acute stroke.
Topics: Administration, Cutaneous; Hemodynamics; Humans; Nitric Oxide Donors; Nitroglycerin; Quality of Life | 2020 |
Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke.
Topics: Acute Disease; Arginine; Brain Ischemia; Enzyme Inhibitors; Headache; Humans; Nitric Oxide Donors; N | 2017 |
[Blood pressure treatment in the acute stage of stroke].
Topics: Acute Disease; Administration, Cutaneous; Antihypertensive Agents; Blood Pressure; Evidence-Based Me | 2015 |
William M. Feinberg Award for Excellence in Clinical Stroke: High Explosive Treatment for Ultra-Acute Stroke: Hype of Hope.
Topics: Acute Disease; Awards and Prizes; Humans; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Stroke; | 2016 |
Therapeutic Potential of Transdermal Glyceryl Trinitrate in the Management of Acute Stroke.
Topics: Administration, Cutaneous; Blood Pressure; Cerebrovascular Circulation; Humans; Nitric Oxide Donors; | 2017 |
[Hypertensive emergency].
Topics: Antihypertensive Agents; Aortic Aneurysm; Aortic Dissection; Emergencies; Humans; Hypertension; Nitr | 2008 |
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
29 trials available for nitroglycerin and Stroke
| Article | Year |
|---|---|
Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.
Topics: Adult; Aged; Ambulances; Brain Ischemia; Hospitals; Humans; Nitroglycerin; Prospective Studies; Stro | 2022 |
Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial.
Topics: Adolescent; Adult; Ambulances; Brain Ischemia; Cerebral Hemorrhage; Humans; Ischemic Attack, Transie | 2022 |
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial.
Topics: Brain Ischemia; Humans; Ischemic Stroke; Neuroprotection; Nitrates; Nitric Oxide; Nitroglycerin; Pil | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Time intervals and distances travelled for prehospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
Topics: Ambulances; Brain Ischemia; Emergency Medical Services; Humans; Hypertension; Nitroglycerin; Prospec | 2022 |
Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data From the RIGHT-2 Trial.
Topics: Acute Disease; Administration, Cutaneous; Aged; Aged, 80 and over; Blood Pressure; Cerebral Hemorrha | 2019 |
Infections Up to 76 Days After Stroke Increase Disability and Death.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Incidence; Infections; Male; Middle Aged; Nitroglyce | 2017 |
Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053).
Topics: Acute Disease; Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Ambulances; Emergency Medi | 2019 |
Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial.
Topics: Aged; Aged, 80 and over; Deglutition Disorders; Feeding Methods; Female; Humans; Male; Middle Aged; | 2018 |
Nitric oxide for inhalation in ST-elevation myocardial infarction (NOMI): a multicentre, double-blind, randomized controlled trial.
Topics: Administration, Inhalation; Aged; Cyclic GMP; Double-Blind Method; Female; Free Radical Scavengers; | 2018 |
Impact of hydration status on haemodynamics, effects of acute blood pressure-lowering treatment, and prognosis after stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Female; Humans; Mal | 2018 |
Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Hypertension; Ischemic Attack, Transient; M | 2019 |
Central adjudication of serious adverse events did not affect trial's safety results: Data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial.
Topics: Administration, Cutaneous; Antihypertensive Agents; Humans; Nitric Oxide; Nitroglycerin; Prospective | 2018 |
Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke.
Topics: Acute Disease; Administration, Cutaneous; Aged; Aged, 80 and over; Blood Pressure; Female; Humans; M | 2019 |
Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial.
Topics: Administration, Cutaneous; Aged; Emergency Medical Services; Female; Humans; Hypertension; Male; Mid | 2019 |
Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial.
Topics: Ambulances; Humans; Logistic Models; Nitroglycerin; Outcome Assessment, Health Care; Randomized Cont | 2019 |
Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial.
Topics: Aged; Aged, 80 and over; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Nitroglyce | 2019 |
Feasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the rapid intervention with glyceryl trinitrate in Hypertensive Stroke Trial (RIGHT, ISRCTN66434824).
Topics: Aged; Aged, 80 and over; Allied Health Personnel; Ambulances; Bandages; Blood Pressure; Cohort Studi | 2013 |
Statistical analysis plan for the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial.
Topics: Administration, Cutaneous; Data Interpretation, Statistical; Humans; Hypertension; Nitric Oxide; Nit | 2014 |
Baseline characteristics of the 4011 patients recruited into the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; | 2014 |
Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Disease Manag | 2015 |
Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Nitric Oxide | 2015 |
[Efficacy of Nitric Oxide, With or Without Continuing Antihypertensive Treatment, for Management of High Blood Pressure in Acute Stroke. Results of the ENOS study].
Topics: Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combi | 2015 |
Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis.
Topics: Acute Disease; Aged; Aged, 80 and over; Cerebral Hemorrhage; Female; Humans; Male; Middle Aged; Nitr | 2016 |
Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Disability Evaluation; Drug Admini | 2016 |
Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122).
Topics: Antihypertensive Agents; Humans; Hypertension; Nitroglycerin; Research Design; Stroke; Vasodilator A | 2006 |
Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial.
Topics: Aged; Aged, 80 and over; Blood Pressure; Carotid Stenosis; Humans; Ischemia; Male; Middle Aged; Nitr | 2009 |
The effect of transdermal glyceryl trinitrate on 24 h ambulatory blood pressure in acute/subacute stroke.
Topics: Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Female; Humans; Hypertension; Male; Nit | 2011 |
Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke.
Topics: Aged; Aged, 80 and over; Blood Pressure; Cerebrovascular Circulation; Double-Blind Method; Female; H | 2006 |
The effect of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure and platelet function in acute stroke.
Topics: Administration, Cutaneous; Aged; Blood Platelets; Blood Pressure; Diastole; Double-Blind Method; Fem | 2001 |
20 other studies available for nitroglycerin and Stroke
| Article | Year |
|---|---|
Measures of intracranial compartments in acute intracerebral haemorrhage: data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2).
Topics: Atrophy; Cerebral Hemorrhage; Humans; Hypertension; Leukoaraiosis; Nitroglycerin; Stroke | 2023 |
Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Atrophy; Brain; Cerebral Small Vessel Diseases; | 2020 |
Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke.
Topics: Brain Ischemia; Cerebrovascular Circulation; Humans; Ischemic Stroke; Nitroglycerin; Perfusion; Stro | 2021 |
Benefits and safety of transdermal glyceryl trinitrate in acute stroke: a systematic review and meta-analysis of randomised trials (protocol).
Topics: Activities of Daily Living; Adult; Aged; Brain Ischemia; Humans; Meta-Analysis as Topic; Nitroglycer | 2021 |
Considering prehospital stroke trials: did RIGHT-2 get it right?
Topics: Ambulances; Emergency Medical Services; Humans; Nitroglycerin; Stroke | 2019 |
Blood pressure in acute stroke: which questions remain?
Topics: Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Nitroglycerin; S | 2015 |
ACP Journal Club: glyceryl trinitrate did not improve functional outcome in patients with acute stroke and high BP.
Topics: Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Nitroglycerin; S | 2015 |
Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke.
Topics: Animals; Brain Ischemia; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Mice; Mice, Inbre | 2018 |
[First aid in stroke: what is the tolerable limit for blood pressure?].
Topics: Antihypertensive Agents; Blood Pressure Determination; Emergency Medical Services; Humans; Hypertens | 2009 |
[Hypertensive urgency or hypertensive emergency?].
Topics: Adult; Antihypertensive Agents; Blood Pressure Determination; Emergencies; Female; Follow-Up Studies | 2010 |
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study.
Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co | 2012 |
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study.
Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co | 2012 |
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study.
Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co | 2012 |
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study.
Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co | 2012 |
Management of blood pressure in acute stroke.
Topics: Administration, Cutaneous; Blood Pressure; Humans; Nitroglycerin; Stroke; Vasodilator Agents | 2002 |
Impact of cerebral protection devices on early outcome of carotid stenting.
Topics: Aged; Blood Vessel Prosthesis Implantation; Carotid Artery, Common; Carotid Stenosis; Cerebrovascula | 2002 |
[On the effect of nitroglycerin on the stroke- and minute volume of the heart].
Topics: Heart; Nitrites; Nitroglycerin; Stroke | 1960 |
Role of NAD(P)H oxidase in alcohol-induced impairment of endothelial nitric oxide synthase-dependent dilation of cerebral arterioles.
Topics: Acetophenones; Acetylcholine; Acridines; Adenosine Diphosphate; Alcohol Drinking; Alcohols; Animals; | 2006 |
Flow-mediated vasodilatation of carotid and brachial arteries in healthy subjects and in lacunar stroke patients.
Topics: Blood Flow Velocity; Brachial Artery; Carotid Artery, Common; Case-Control Studies; Female; Humans; | 2006 |
Nitric oxide release is impaired in hypertensive individuals with familial history of stroke.
Topics: Adult; Blood Flow Velocity; Endothelium, Vascular; Enzyme Inhibitors; Female; Genetic Predisposition | 2006 |
Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression.
Topics: Animals; Blotting, Western; Brain Ischemia; Cerebral Cortex; Functional Laterality; Gene Expression; | 2007 |
Acute chest pain and ST-elevation during patent foramen ovale closure.
Topics: Acute Disease; Adult; Analgesics, Opioid; Cardiac Catheterization; Catheterization; Chest Pain; Colo | 2008 |
Blood pressure management in acute stroke: comparison of current guidelines with prescribing patterns.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Female | 2002 |