nitroglycerin has been researched along with Spasm in 86 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to compare the efficacy of nitroglycerin and diltiazem versus nitroglycerin alone in preventing radial artery spasm (RAS) during transradial coronary procedures." | 9.16 | Nitroglycerin plus diltiazem versus nitroglycerin alone for spasm prophylaxis with transradial approach. ( Dharma, S; Pancholy, S; Patel, T; Radadiya, R; Shah, S; Vyas, C, 2012) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 9.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "Nitroglycerin is preferable to diltiazem for prevention of conduit spasm." | 9.09 | Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm. ( Aldea, GS; Alkon, JD; Keaney, JF; Macron, DS; Shapira, OM; Shemin, RJ; Vita, JA, 2000) |
| "In phenoxybenzamine-treated sections of radial artery, circulating vasoconstrictor agonists may still contribute to the induction of spasm." | 7.72 | Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. ( Chester, MR; Conant, AR; Dihmis, WC; Oo, AY; Shackcloth, MJ; Simpson, AW, 2003) |
| "There are few reports regarding the concordance of coronary arterial response between acetylcholine (ACh) and ergonovine (ER) spasm provocation tests." | 7.72 | Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations. ( Fukuda, H; Hayashi, Y; Kawada, H; Kohno, H; Ochi, N; Sueda, S; Uraoka, T, 2004) |
| "In this study the effect of glyceryl trinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was evaluated in nine female patients with sphincter of Oddi dyskinesia." | 7.69 | Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration. ( Csernay, L; Lonovics, J; Madácsy, L; Velosy, B, 1997) |
| "We report clinical experience with the coronary vasodilator nifedipine in 127 patients with symptoms of myocardial ischemia associated with electrocardiographic or angiographic evidence, or both, of coronary-artery spasm." | 7.66 | Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. ( Achuff, S; Antman, E; Braunwald, E; Geltman, E; Goldberg, S; Heupler, F; Kerin, NZ; Liang, CS; MacAlpin, R; Muller, J; Neff, RK; Reichek, N; Rubenfire, M; Tabatznik, B, 1980) |
| "Recent experience has suggested that the ergonovine maleate test is a safe procedure for the diagnosis of variant angina pectoris, because ergonovine-induced coronary vasospasm has generally been reversible by sublingual nitroglycerin." | 7.66 | Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin. ( Buxton, A; Goldberg, S; Hirshfeld, JW; Mann, T; Oliva, P; Overlie, P; Williams, DO; Wilson, J, 1980) |
| "Anal sphincter spasm is a common finding in patients with anal fissure disease." | 5.30 | Topical nitroglycerin in the management of anal fissure: an explosive outcome! ( Cooperman, H; Fleshner, P; Manookian, CM; Moore, B; Sokol, T; Teng, F, 1998) |
| "The spasm was refractory to oral calcium channel blocking agents and direct intraarterial infusion of tolazoline (Priscoline)." | 5.27 | Bilateral upper extremity ischemia after administration of dihydroergotamine-heparin for prophylaxis of deep venous thrombosis. ( Blackshear, WM; Cruse, CW; Schwartz, JA; Seifert, KB; Suslavitch, F, 1988) |
| "The aim of this study was to compare the efficacy of nitroglycerin and diltiazem versus nitroglycerin alone in preventing radial artery spasm (RAS) during transradial coronary procedures." | 5.16 | Nitroglycerin plus diltiazem versus nitroglycerin alone for spasm prophylaxis with transradial approach. ( Dharma, S; Pancholy, S; Patel, T; Radadiya, R; Shah, S; Vyas, C, 2012) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 5.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "Nitroglycerin is preferable to diltiazem for prevention of conduit spasm." | 5.09 | Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm. ( Aldea, GS; Alkon, JD; Keaney, JF; Macron, DS; Shapira, OM; Shemin, RJ; Vita, JA, 2000) |
| "The benefits of nitroglycerin are numerous, from ensuring accurate interpretation of diagnostic angiograms to treatment of coronary spasm and support of PCIs in simple or complex lesion types." | 3.85 | Nitroglycerin and the enduring principles of coronary procedures. ( Topaz, O, 2017) |
| "In phenoxybenzamine-treated sections of radial artery, circulating vasoconstrictor agonists may still contribute to the induction of spasm." | 3.72 | Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. ( Chester, MR; Conant, AR; Dihmis, WC; Oo, AY; Shackcloth, MJ; Simpson, AW, 2003) |
| "There are few reports regarding the concordance of coronary arterial response between acetylcholine (ACh) and ergonovine (ER) spasm provocation tests." | 3.72 | Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations. ( Fukuda, H; Hayashi, Y; Kawada, H; Kohno, H; Ochi, N; Sueda, S; Uraoka, T, 2004) |
| "In this study the effect of glyceryl trinitrate on the prostigmine-morphine-induced sphincter of Oddi spasm was evaluated in nine female patients with sphincter of Oddi dyskinesia." | 3.69 | Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration. ( Csernay, L; Lonovics, J; Madácsy, L; Velosy, B, 1997) |
| "We report clinical experience with the coronary vasodilator nifedipine in 127 patients with symptoms of myocardial ischemia associated with electrocardiographic or angiographic evidence, or both, of coronary-artery spasm." | 3.66 | Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. ( Achuff, S; Antman, E; Braunwald, E; Geltman, E; Goldberg, S; Heupler, F; Kerin, NZ; Liang, CS; MacAlpin, R; Muller, J; Neff, RK; Reichek, N; Rubenfire, M; Tabatznik, B, 1980) |
| "Recent experience has suggested that the ergonovine maleate test is a safe procedure for the diagnosis of variant angina pectoris, because ergonovine-induced coronary vasospasm has generally been reversible by sublingual nitroglycerin." | 3.66 | Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin. ( Buxton, A; Goldberg, S; Hirshfeld, JW; Mann, T; Oliva, P; Overlie, P; Williams, DO; Wilson, J, 1980) |
| " Subsequent angiography revealed normal coronary anatomy with spasm of the right coronary artery that disappeared after ingestion of one sublingual nitroglycerin tablet." | 3.66 | Coronary spasm with ventricular fibrillation during thyrotoxicosis: response to attaining euthyroid state. ( Achuff, SC; Genecin, A; Greene, HL; Wei, JY, 1979) |
| "Coronary artery spasm was induced by intravascular administration of ergonovine maleate (Ergotrate) during cardiac catheterization." | 3.65 | Coronary artery spasm. medical management, surgical denervation, and autotransplantation. ( Angell, WW; Clark, DA; Mitchell, RL; Quint, RA, 1977) |
| " He had a normal left coronary arteriogram when the diffuse spasm was relieved by nitroglycerin." | 3.65 | Coronary hypertonia and angina. ( Choquet, Y; Lapointe, L; Levy, R; Primeau, R; Proulx, J, 1974) |
| "Coronary spasm has been described in the context of carcinoid heart disease, but few information are available over perioperative coronary spasm." | 1.39 | Early diffuse coronary artery spasm after heart valve surgery in the carcinoid syndrome. ( Anselmi, A; Boulmier, D; Corbineau, H; Ruggieri, VG, 2013) |
| "Radial artery spasm is a frequent complication of the transradial approach for coronary angiography and angioplasty." | 1.32 | Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures. ( Eccleshall, SC; Kiemeneij, F; Laarman, G; Slagboom, T; Vajifdar, BU; van der Wieken, R, 2003) |
| "Nitroglycerin ointment is a newly described treatment for several painful anal conditions." | 1.30 | Treatment of proctalgia fugax with topical nitroglycerin: report of a case. ( Cataldo, PA; Lowenstein, B, 1998) |
| "Anal sphincter spasm is a common finding in patients with anal fissure disease." | 1.30 | Topical nitroglycerin in the management of anal fissure: an explosive outcome! ( Cooperman, H; Fleshner, P; Manookian, CM; Moore, B; Sokol, T; Teng, F, 1998) |
| "The spasm was refractory to oral calcium channel blocking agents and direct intraarterial infusion of tolazoline (Priscoline)." | 1.27 | Bilateral upper extremity ischemia after administration of dihydroergotamine-heparin for prophylaxis of deep venous thrombosis. ( Blackshear, WM; Cruse, CW; Schwartz, JA; Seifert, KB; Suslavitch, F, 1988) |
| "Coronary spasm is due to strong contraction of coronary vascular smooth muscle cells which is triggered by an increase of intracellular calcium ions; hyperventilation plus TRIS-buffer infusion induces coronary spasm by decreasing hydrogen ions which antagonize the action of calcium ions." | 1.26 | Pathophysiology and treatment of coronary arterial spasm. ( Yasue, H, 1980) |
| "Coronary spasm was triggered in 16 cases, reproducing the chest pain in 11 patients, and accompanied by electrical changes in 15 cases, 12 subepicardial ischaemias and 3 subendocardial ischaemias." | 1.26 | [Methyl-ergometrin maleate test during coronary arteriography in spontaneous chest pain]. ( Benacerraf, A; Castillo-Fenoy, A; Tonnelier, M; Wagniart, P, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (51.16) | 18.7374 |
| 1990's | 13 (15.12) | 18.2507 |
| 2000's | 14 (16.28) | 29.6817 |
| 2010's | 8 (9.30) | 24.3611 |
| 2020's | 7 (8.14) | 2.80 |
| Authors | Studies |
|---|---|
| da Silva, RL | 2 |
| de Andrade, PB | 2 |
| Dangas, G | 1 |
| Joaquim, RM | 2 |
| da Silva, TRW | 2 |
| Vieira, RG | 1 |
| Pereira, VC | 2 |
| Sousa, AGM | 2 |
| Feres, F | 2 |
| Costa, JR | 2 |
| Abdelazeem, B | 1 |
| Abuelazm, MT | 1 |
| Swed, S | 1 |
| Gamal, M | 1 |
| Atef, M | 1 |
| Al-Zeftawy, MA | 1 |
| Noori, MA | 1 |
| Lutz, A | 1 |
| Volgman, AS | 1 |
| Jin, J | 1 |
| Unasa, H | 1 |
| Bahl, P | 1 |
| Mauiliu-Wallis, M | 1 |
| Svirskis, D | 1 |
| Hill, A | 1 |
| Economou, FI | 1 |
| Doundoulakis, I | 1 |
| Kalamakidou, I | 1 |
| Koliastasis, L | 1 |
| Soulaidopoulos, S | 1 |
| Samara, M | 1 |
| Dimitriadis, K | 1 |
| Papazisis, G | 1 |
| Tsiachris, D | 1 |
| Tsioufis, K | 1 |
| Dangas, GD | 1 |
| Fattah, T | 1 |
| Zanella, RA | 1 |
| Angelini, P | 1 |
| Uribe, C | 1 |
| Salem, PA | 1 |
| Murai, K | 1 |
| Fujino, M | 1 |
| Kataoka, Y | 1 |
| Noguchi, T | 1 |
| Topaz, O | 1 |
| Anselmi, A | 1 |
| Corbineau, H | 1 |
| Boulmier, D | 1 |
| Ruggieri, VG | 1 |
| Blasco-Navalpotro, MÁ | 1 |
| Orejas-Gallego, A | 1 |
| Flordelís-Lasierra, JL | 1 |
| Prior-Gómez, N | 1 |
| Jiménez-Jiménez, J | 1 |
| Seoane-Leston, FJ | 1 |
| Collet, C | 1 |
| Corral, JM | 1 |
| Cavalcante, R | 1 |
| Tateishi, H | 1 |
| Belzarez, O | 1 |
| Ribamar Costa, J | 1 |
| Costa, R | 1 |
| Chamié, D | 1 |
| Onuma, Y | 1 |
| de Winter, RJ | 1 |
| Abizaid, A | 1 |
| Serruys, PW | 1 |
| Yoshizaki, T | 1 |
| Tabuchi, N | 1 |
| Toyama, M | 1 |
| Alcock, R | 1 |
| Lowe, HC | 1 |
| Dharma, S | 1 |
| Shah, S | 1 |
| Radadiya, R | 1 |
| Vyas, C | 1 |
| Pancholy, S | 1 |
| Patel, T | 1 |
| Asghar, H | 1 |
| Shroff, A | 1 |
| Clemens, RK | 1 |
| Lillis, AP | 1 |
| Alomari, AI | 1 |
| Seniuk, W | 1 |
| Mularek-Kubzdela, T | 1 |
| Grygier, M | 1 |
| Grajek, S | 1 |
| Cieśliński, A | 1 |
| Kiemeneij, F | 1 |
| Vajifdar, BU | 1 |
| Eccleshall, SC | 1 |
| Laarman, G | 1 |
| Slagboom, T | 1 |
| van der Wieken, R | 1 |
| Conant, AR | 1 |
| Shackcloth, MJ | 1 |
| Oo, AY | 1 |
| Chester, MR | 1 |
| Simpson, AW | 1 |
| Dihmis, WC | 1 |
| Sueda, S | 1 |
| Kohno, H | 1 |
| Fukuda, H | 1 |
| Ochi, N | 1 |
| Kawada, H | 1 |
| Hayashi, Y | 1 |
| Uraoka, T | 1 |
| Chen, CW | 1 |
| Lin, CL | 1 |
| Lin, TK | 1 |
| Lin, CD | 1 |
| Muralidharan, V | 1 |
| Jamidar, P | 1 |
| Bertrand, OF | 1 |
| Larose, E | 1 |
| Rodés-Cabau, J | 1 |
| Tarhan, IA | 1 |
| Kehlibar, T | 1 |
| Arslan, Y | 1 |
| Yilmaz, M | 1 |
| Dumantepe, M | 1 |
| Berkoz, K | 1 |
| Pancaroglu, C | 1 |
| Ozler, A | 1 |
| Riboulot, M | 1 |
| Pizzalla, L | 1 |
| Myon, Y | 1 |
| Malgouzou, M | 1 |
| Henry, X | 1 |
| Stoppa, R | 1 |
| Beinart, C | 1 |
| Sos, TA | 1 |
| Saddekni, S | 1 |
| Weiner, MA | 1 |
| Sniderman, KW | 1 |
| Blackwell, JN | 1 |
| Castell, DO | 1 |
| Zmyslowski, WP | 1 |
| Burstow, D | 1 |
| Murphy, A | 1 |
| Dumont, L | 1 |
| LeLorier, J | 1 |
| Stanley, P | 1 |
| Chartrand, C | 1 |
| Antman, E | 1 |
| Muller, J | 1 |
| Goldberg, S | 2 |
| MacAlpin, R | 1 |
| Rubenfire, M | 1 |
| Tabatznik, B | 1 |
| Liang, CS | 1 |
| Heupler, F | 1 |
| Achuff, S | 1 |
| Reichek, N | 1 |
| Geltman, E | 1 |
| Kerin, NZ | 1 |
| Neff, RK | 1 |
| Braunwald, E | 1 |
| Conti, CR | 2 |
| Curry, RC | 1 |
| MacAlpin, RN | 1 |
| Ginsburg, R | 1 |
| Bristow, MR | 1 |
| Harrison, DC | 2 |
| Stinson, EB | 1 |
| Yasue, H | 1 |
| Buxton, A | 1 |
| Hirshfeld, JW | 1 |
| Wilson, J | 1 |
| Mann, T | 1 |
| Williams, DO | 1 |
| Overlie, P | 1 |
| Oliva, P | 1 |
| Erbel, R | 1 |
| Effert, S | 1 |
| Wessén, A | 1 |
| Elowsson, P | 1 |
| Axemo, P | 1 |
| Lindberg, B | 1 |
| Izzat, MB | 1 |
| West, RR | 1 |
| Ragoonanan, C | 1 |
| Angelini, GD | 1 |
| Ding, YY | 1 |
| Malone-Lee, JG | 1 |
| Park, SJ | 1 |
| Park, SW | 1 |
| Kim, JJ | 1 |
| Song, JK | 1 |
| Hong, MK | 1 |
| Kang, DH | 1 |
| Cheong, SS | 1 |
| Lee, CW | 1 |
| Lee, JK | 1 |
| Dufour, P | 1 |
| Vinatier, D | 1 |
| Bouthors, AS | 1 |
| Orazi, G | 1 |
| Subtil, D | 1 |
| Monnier, JC | 1 |
| Puech, F | 1 |
| Feliu Palá, X | 1 |
| Encinas Méndez, X | 1 |
| Poveda Gómez, S | 1 |
| Martí Sintes, G | 1 |
| Velosy, B | 1 |
| Madácsy, L | 1 |
| Lonovics, J | 1 |
| Csernay, L | 1 |
| Lund, JN | 1 |
| Scholefield, JH | 1 |
| Lowenstein, B | 1 |
| Cataldo, PA | 1 |
| Manookian, CM | 1 |
| Fleshner, P | 1 |
| Moore, B | 1 |
| Teng, F | 1 |
| Cooperman, H | 1 |
| Sokol, T | 1 |
| Brisinda, G | 1 |
| Maria, G | 1 |
| Bentivoglio, AR | 1 |
| Cassetta, E | 1 |
| Gui, D | 1 |
| Albanese, A | 1 |
| Hallett, M | 1 |
| Shapira, OM | 1 |
| Alkon, JD | 1 |
| Macron, DS | 1 |
| Keaney, JF | 1 |
| Vita, JA | 1 |
| Aldea, GS | 1 |
| Shemin, RJ | 1 |
| Rinaldi, G | 1 |
| Navia, D | 1 |
| Vaccarino, G | 1 |
| Segura, E | 1 |
| Albertal, J | 1 |
| Toyoyama, H | 1 |
| Kariya, N | 1 |
| Hase, I | 1 |
| Toyoda, Y | 1 |
| Bittar, DA | 1 |
| Reddy, P | 1 |
| White, CM | 1 |
| Song, J | 1 |
| Johnson, AD | 1 |
| Stroud, HA | 1 |
| Vieweg, WV | 1 |
| Ross, J | 1 |
| Feldman, RL | 1 |
| Pepine, CJ | 1 |
| Hansen, JF | 1 |
| Sandøe, E | 1 |
| Liss, JP | 1 |
| Wei, JY | 1 |
| Genecin, A | 1 |
| Greene, HL | 1 |
| Achuff, SC | 1 |
| Benacerraf, A | 2 |
| Castillo-Fenoy, A | 1 |
| Tonnelier, M | 2 |
| Wagniart, P | 1 |
| Friedman, AC | 1 |
| Spindola-Franco, H | 1 |
| Nivatpumin, T | 1 |
| Salem, BI | 1 |
| Terasawa, M | 1 |
| Mathur, VS | 1 |
| Garcia, E | 1 |
| de Castro, CM | 1 |
| Hall, RJ | 1 |
| Fenoy, AC | 1 |
| Hennetier, G | 1 |
| Morin, B | 1 |
| Bertrand, ME | 2 |
| Lablanche, JM | 1 |
| Tilmant, PY | 1 |
| Clark, DA | 1 |
| Quint, RA | 1 |
| Mitchell, RL | 1 |
| Angell, WW | 1 |
| Laisné, C | 1 |
| Lefebvre, JM | 1 |
| Carré, A | 1 |
| Warembourg, H | 1 |
| Lekieffre, J | 1 |
| Robertson, WC | 1 |
| Guglielmo, LD | 1 |
| Montemartini, C | 1 |
| Bobba, P | 1 |
| Specchia, G | 1 |
| Angoli, L | 1 |
| Deservi, S | 1 |
| Mussini, A | 1 |
| Marinoni, GP | 1 |
| Kinoshita, K | 1 |
| Matsuzaki, K | 1 |
| Mayumi, H | 1 |
| Asou, T | 1 |
| Masuda, M | 1 |
| Kawachi, Y | 1 |
| Tokunaga, K | 1 |
| Dalvi, BV | 1 |
| Gupta, KG | 1 |
| Munsi, SC | 1 |
| Vengsarkar, AS | 1 |
| Geller, LI | 1 |
| Petrenko, VF | 1 |
| Schott, G | 1 |
| Riedel, K | 1 |
| Jett, GK | 1 |
| Arcici, JM | 1 |
| Hatcher, CR | 1 |
| Abel, PW | 1 |
| Guyton, RA | 1 |
| Seifert, KB | 1 |
| Blackshear, WM | 1 |
| Cruse, CW | 1 |
| Schwartz, JA | 1 |
| Suslavitch, F | 1 |
| Orlando, RC | 1 |
| Bozymski, EM | 1 |
| Hart, NJ | 1 |
| Silverman, ME | 1 |
| King, SB | 1 |
| Schroeder, JS | 1 |
| Silverman, JF | 1 |
| Choquet, Y | 1 |
| Proulx, J | 1 |
| Primeau, R | 1 |
| Lapointe, L | 1 |
| Levy, R | 1 |
| Morgan, MG | 1 |
| Hellstrom, HR | 1 |
| King, MJ | 1 |
| Zir, LM | 1 |
| Kaltman, AJ | 1 |
| Fox, AC | 1 |
| Demany, MA | 1 |
| Tambe, A | 1 |
| Zimmerman, HA | 1 |
| Kareva, GF | 1 |
| Kramer, P | 1 |
| Kurz, JF | 1 |
| Shore, JM | 1 |
| Silverman, A | 1 |
| Siegel, M | 1 |
| Bakal, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention[NCT02832115] | Phase 4 | 100 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638] | 240 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | |||
| Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy[NCT00927849] | 63 participants (Actual) | Interventional | 2002-09-30 | Completed | |||
| Botulin Toxin Versus Isosorbidedinitrate Ointment in Treatment Anal Fissure; A Prospective, Blinded, Randomized Trial[NCT00827736] | Phase 4 | 73 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in Radial artery cross sectional area in mm^2 - Before application of topical nitroglycerine / placebo (Pre dilation) vs Prior to arterial puncture after application of topical nitroglycerine / placebo (Post-dilation) (NCT02832115)
Timeframe: Application of nitroglycerine / placebo until prior to arterial puncture. Approximate 60 to 120 minutes
| Intervention | mm^2 (Mean) |
|---|---|
| Study | 2.5 |
| Control | -0.2 |
Need to abort procedure or convert to transfemoral access (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
| Intervention | Participants (Count of Participants) |
|---|---|
| Study | 0 |
| Control | 4 |
Patient discomfort or pain during procedure measured using Visual analog scale 0-10, 0 being no discomfort or pain (best) and 10 being worst discomfort or pain (worst) (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
| Intervention | score on a scale (Mean) |
|---|---|
| Study | 0.792 |
| Control | 0.875 |
"Incidence of radial artery spasm indicated by a Radial artery spasm score of 1 or more. Radial artery spasm score is sum of:~Intraprocedural pain in the forearm aggravated by movement of the catheter/sheath - Absent :0; Present:1~Difficulty in manipulating the catheter- Absence :0; Present:1~Difficulty with sheath removal: Absent: 0; Present:1~Additional use of intraarterial nitroglycerine or verapamil after the initial vasodilator cocktail- No:0; Yes:1" (NCT02832115)
Timeframe: Intraprocedural: From procedure start to application of radial band. Approximate time 30 to 90 minutes.
| Intervention | Participants (Count of Participants) |
|---|---|
| Study | 8 |
| Control | 15 |
Radial pulse at end of procedure 0- 4+, 0 indicating no palpable pulse (worst); 1 + indicating a faint, but detectable pulse; 2 + suggesting a slightly more diminished pulse than normal; 3 + is a normal pulse; and 4 + indicating a bounding pulse (best). (NCT02832115)
Timeframe: At the end of transradial cardiac catheterization after sheath removal
| Intervention | score on a scale (Mean) |
|---|---|
| Study | 2.208333333 |
| Control | 2.166666667 |
using a visual analog scale (VAS) with which each patients noted the severity of pain at each evaluated time using a linear between zero (no pain) and 10 ( severe pain) (NCT00927849)
Timeframe: one year after the procedure
| Intervention | score in scale (Mean) |
|---|---|
| Surgical Group Lateral Sphincterotomy | 4.16 |
| Glycein Trinitrate Group | 4.18 |
| Botilinium Toxin Injection | 4.2 |
5 reviews available for nitroglycerin and Spasm
| Article | Year |
|---|---|
The efficacy of nitroglycerin to prevent radial artery spasm and occlusion during and after transradial catheterization: A systematic review and meta-analysis of randomized controlled trials.
Topics: Arterial Occlusive Diseases; Cardiac Catheterization; Humans; Nitroglycerin; Radial Artery; Randomiz | 2022 |
Can Targeting Sphincter Spasm Reduce Post-Haemorrhoidectomy Pain? A Systematic Review and Meta-Analysis.
Topics: Botulinum Toxins; Diltiazem; Hemorrhoidectomy; Humans; Nitroglycerin; Pain, Postoperative; Spasm | 2023 |
[Coronary spasm. Clinical significance and therapeutic consequences].
Topics: Angina Pectoris, Variant; Cardiac Catheterization; Coronary Disease; Electrocardiography; Humans; Ni | 1981 |
[Coronary artery spasm (author's transl)].
Topics: Coronary Disease; Humans; Nitroglycerin; Radiography; Spasm | 1979 |
[Nitrolingual spray in coronary spasms].
Topics: Adult; Aerosols; Aged; Angina Pectoris; Biliary Tract Diseases; Colic; Coronary Disease; Diagnosis, | 1970 |
9 trials available for nitroglycerin and Spasm
| Article | Year |
|---|---|
Randomized Clinical Trial on Prevention of Radial Occlusion After Transradial Access Using Nitroglycerin: PATENS Trial.
Topics: Arterial Occlusive Diseases; Cardiac Catheterization; Humans; Nitroglycerin; Prospective Studies; Ra | 2022 |
Prevention of Radial Artery Spasm With Transdermal Glyceryl Trinitrate Patches: The NURSE-TTS Randomized Study.
Topics: Humans; Nitroglycerin; Peripheral Vascular Diseases; Radial Artery; Spasm; Treatment Outcome; Vasodi | 2023 |
Pressure-mediated versus pharmacologic treatment of radial artery spasm during cardiac catheterisation: a randomised pilot study.
Topics: Aged; Cardiac Catheterization; Female; Humans; Male; Middle Aged; Nitroglycerin; Pilot Projects; Pro | 2017 |
Nitroglycerin plus diltiazem versus nitroglycerin alone for spasm prophylaxis with transradial approach.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Cardiovascular Diseases; Diltiazem; Drug Thera | 2012 |
A simple and effective regimen for prevention of radial artery spasm during coronary catheterization.
Topics: Aged; Anticoagulants; Blood Pressure; Cardiac Catheterization; Female; Heparin; Humans; Male; Middle | 2006 |
Effects of normothermic organ bath and verapamil-nitroglycerin solution alone or in combination on the blood flow of radial artery.
Topics: Adult; Aged; Body Temperature; Drug Combinations; Female; Humans; Hypothermia, Induced; Male; Middle | 2007 |
Effect of systemic vasodilators on internal mammary artery flow. Implications for postoperative treatment after myocardial revascularization.
Topics: Blood Flow Velocity; Dobutamine; Enoximone; Female; Humans; Internal Mammary-Coronary Artery Anastom | 1994 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm.
Topics: Coronary Artery Bypass; Costs and Cost Analysis; Creatine Kinase; Diltiazem; Female; Humans; Isosorb | 2000 |
72 other studies available for nitroglycerin and Spasm
| Article | Year |
|---|---|
Effect of randomized prophylactic nitroglycerin on radial artery spasm during transradial catheterization: An analysis based on operator experience.
Topics: Cardiac Catheterization; Humans; Nitroglycerin; Radial Artery; Spasm; Treatment Outcome; Vasodilator | 2023 |
Can Significant Coronary Artery Disease Coexist With Transient Takotsubo Cardiomyopathy, and How Does Spasm Interrelate?
Topics: Aged, 80 and over; Coronary Angiography; Coronary Artery Disease; Electrocardiography; Female; Human | 2023 |
Transdermal Nitroglycerin Patch as a Potential Pretreatment to Prevent Radial Artery Spasm During Transradial Cardiac Catheterization.
Topics: Cardiac Catheterization; Humans; Nitroglycerin; Radial Artery; Spasm; Transdermal Patch; Vasodilator | 2021 |
Nitroglycerin and the enduring principles of coronary procedures.
Topics: Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Humans; Nitroglycerin; Percutaneous Coro | 2017 |
Early diffuse coronary artery spasm after heart valve surgery in the carcinoid syndrome.
Topics: Aged; Carcinoid Heart Disease; Coronary Angiography; Coronary Artery Disease; Heart Failure; Humans; | 2013 |
Coronary spasm secondary to biphasic anaphylaxis after hymenoptera stings.
Topics: Allergens; Anaphylaxis; Angina, Unstable; Animals; Emergency Medical Services; Humans; Hydrocortison | 2016 |
Verapamil and nitroglycerin improves the patency rate of radial artery grafts.
Topics: Administration, Topical; Aged; Coronary Artery Bypass; Drug Combinations; Female; Graft Occlusion, V | 2008 |
Acute leg pain due to iliac artery spasm during coronary angiography: an unusual consequence of an uncommon problem.
Topics: Acute Disease; Aged; Analgesics, Opioid; Coronary Angiography; Fentanyl; Humans; Iliac Artery; Leg; | 2011 |
Preventing spasm during transradial angiography: sometimes less is more.
Topics: Angioplasty, Balloon, Coronary; Diltiazem; Female; Humans; Male; Nitroglycerin; Radial Artery; Spasm | 2012 |
Catheter-induced venous spasm.
Topics: Adolescent; Catheterization; Catheters; Humans; Male; Muscle, Smooth, Vascular; Nitroglycerin; Phleb | 2012 |
Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study.
Topics: Amiodarone; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Car | 2002 |
Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures.
Topics: Aged; Angina Pectoris; Angioplasty; Coronary Angiography; Drug Therapy, Combination; Female; Humans; | 2003 |
Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators.
Topics: Adrenergic alpha-Agonists; Aged; Angiotensin II; Coronary Artery Bypass; Diltiazem; Dose-Response Re | 2003 |
Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations.
Topics: Acetylcholine; Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Ergonovine; Female; Human | 2004 |
Pharmacologic prevention of post-ERCP pancreatitis: is nitroglycerin a sangreal?
Topics: Catheterization; Cholangiopancreatography, Endoscopic Retrograde; Humans; Nitroglycerin; Pancreatiti | 2006 |
Sub-cutaneous nitroglycerin: good example of the "KISS" rule!
Topics: Catheterization; Humans; Injections, Subcutaneous; Nitroglycerin; Radial Artery; Spasm; Vasodilator | 2007 |
[Nitroglycerin test IV in biliary surgery. Comparison with amyl nitrite (author's transl)].
Topics: Adult; Aged; Ampulla of Vater; Amyl Nitrite; Blood Pressure; Cholelithiasis; Female; Gallstones; Hum | 1981 |
Arterial spasm during renal angioplasty.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Arteriosclerosis; Child; | 1983 |
Oesophageal chest pain: a point of view.
Topics: Calcium Channel Blockers; Diagnosis, Differential; Esophageal Diseases; Heart Diseases; Humans; Hydr | 1984 |
Treating peripheral venospasm.
Topics: Humans; Nitroglycerin; Ointments; Spasm; Veins | 1984 |
The recognition and early management of acute myocardial infarction.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Aortic Aneurysm; Aortic Dissection; Australia; Diagnosis, Diffe | 1984 |
Effect of nitroglycerin on regional myocardial blood flow following an experimental coronary spasm.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Heart Ventricles; Hemodynamics; Nitroglycerin | 1984 |
Nifedipine therapy for coronary-artery spasm. Experience in 127 patients.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Coronary Disease; Female; Humans; Male; Midd | 1980 |
Coronary artery spasm and myocardial ischemia.
Topics: Angina Pectoris, Variant; Coronary Disease; Ergonovine; Humans; Myocardial Infarction; Nitroglycerin | 1980 |
Relation of coronary arterial spasm to sites of organic stenosis.
Topics: Angina Pectoris; Angina Pectoris, Variant; Constriction, Pathologic; Coronary Disease; Coronary Vess | 1980 |
Studies with isolated human coronary arteries. Some general observations, potential mediators of spasm, role of calcium antagonists.
Topics: Acetylcholine; Animals; Calcium; Cattle; Coronary Vessels; Diltiazem; Dogs; Ergonovine; Gallopamil; | 1980 |
Pathophysiology and treatment of coronary arterial spasm.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Atropine; Calcium; Coronary Disease; Coronary Vess | 1980 |
Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin.
Topics: Administration, Oral; Adult; Cardiac Catheterization; Coronary Care Units; Coronary Vessels; Ergonov | 1980 |
The use of intravenous nitroglycerin for emergency cervico-uterine relaxation.
Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Cervix Uteri; Emergencies; Female; Humans; Inje | 1995 |
Glyceryl trinitrate and external urethral sphincter spasm.
Topics: Administration, Topical; Adult; Female; Humans; Nitroglycerin; Spasm; Urethral Diseases | 1993 |
Increased basal tone and hyperresponsiveness to acetylcholine and ergonovine in spasm related coronary arteries in patients with variant angina--basal coronary artery tone in patients with variant angina.
Topics: Acetylcholine; Angina Pectoris, Variant; Coronary Vessels; Dose-Response Relationship, Drug; Ergonov | 1996 |
[Intravenous use of nitroglycerin for emergency relaxation of the cervix and uterus. A case report].
Topics: Adult; Emergencies; Female; Fetal Membranes, Premature Rupture; Humans; Injections, Intravenous; Nit | 1996 |
[Topical nitroglycerin: an alternative in the conservative treatment of biliary fistula].
Topics: Administration, Topical; Aged; Biliary Fistula; Cholecystectomy, Laparoscopic; Humans; Male; Nitrogl | 1996 |
Effect of glyceryl trinitrate on the sphincter of Oddi spasm evoked by prostigmine-morphine administration.
Topics: Adult; Aged; Analgesics, Opioid; Aspartate Aminotransferases; Biliary Tract; Cholinesterase Inhibito | 1997 |
Internal sphincter spasm in anal fissure.
Topics: Adolescent; Adult; Aged; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin; Ointments | 1997 |
Treatment of proctalgia fugax with topical nitroglycerin: report of a case.
Topics: Administration, Topical; Anus Diseases; Female; Humans; Middle Aged; Nitroglycerin; Rectal Diseases; | 1998 |
Topical nitroglycerin in the management of anal fissure: an explosive outcome!
Topics: Administration, Topical; Adult; Aged; Anal Canal; Combined Modality Therapy; Dose-Response Relations | 1998 |
One man's poison--clinical applications of botulinum toxin.
Topics: Administration, Topical; Botulinum Toxins; Botulinum Toxins, Type A; Fissure in Ano; Humans; Injecti | 1999 |
[Vasodilators in isolated human radial arteries].
Topics: Aged; Coronary Artery Bypass; Diltiazem; Humans; Male; Middle Aged; Nitroglycerin; Radial Artery; Sp | 2000 |
The use of intravenous nitroglycerin in a case of spasm of the sphincter of Oddi during laparoscopic cholecystectomy.
Topics: Cholecystectomy, Laparoscopic; Common Bile Duct Diseases; Female; Humans; Infusions, Intravenous; Mi | 2001 |
Nitroglycerine and sphincter of Oddi spasm.
Topics: Humans; Intraoperative Complications; Nitroglycerin; Spasm; Sphincter of Oddi; Vasodilator Agents | 2001 |
Cost analysis of diltiazem and nitroglycerin for the prevention of coronary bypass conduit spasm.
Topics: Coronary Artery Bypass; Costs and Cost Analysis; Diltiazem; Humans; Nitroglycerin; Spasm; Vasodilato | 2001 |
Variant angina pectoris. Clinical presentations, coronary angiographic patterns, and the results of medical and surgical management in 42 consecutive patients.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Coronary Angiography; Electrocardiography; E | 1978 |
Unusual vasomotor coronary arterial responses after nitroglycerin.
Topics: Administration, Oral; Angina Pectoris; Catheterization; Contrast Media; Coronary Angiography; Corona | 1978 |
Treatment of Prinzmetal's angina due to coronary artery spasm using verapamil: a report of three cases.
Topics: Angina Pectoris; Angina Pectoris, Variant; Atropine; Coronary Disease; Electrocardiography; Heart Bl | 1978 |
Ergonovine meleate, angina-like syndrome and coronary spasm.
Topics: Angina Pectoris; Coronary Disease; Ergonovine; Humans; Nitroglycerin; Spasm | 1978 |
Coronary spasm with ventricular fibrillation during thyrotoxicosis: response to attaining euthyroid state.
Topics: Coronary Angiography; Coronary Disease; Electrocardiography; Female; Humans; Hyperthyroidism; Middle | 1979 |
[Methyl-ergometrin maleate test during coronary arteriography in spontaneous chest pain].
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Blood Pressure; Corona | 1979 |
Coronary spasm: Prinzmetal's variant angina vs. catheter-induced spasm; refractory spasm vs. fixed stenosis.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Cardiac Catheterization; Coronary Disease; D | 1979 |
Left main coronary artery ostial stenosis: clinical markers, angiographic recognition and distinction from left main disease.
Topics: Adult; Aged; Coronary Artery Bypass; Coronary Disease; Electrocardiography; Exercise Test; Hemodynam | 1979 |
[The ergometrine methyl maleate test in the study of coronary spasm (author's transl)].
Topics: Angina Pectoris; Coronary Disease; Electrocardiography; Ergonovine; Humans; Myocardial Infarction; N | 1979 |
Coronary artery spasm. medical management, surgical denervation, and autotransplantation.
Topics: Adult; Angina Pectoris, Variant; Cardiac Catheterization; Coronary Artery Bypass; Coronary Disease; | 1977 |
[Coronary artery spasms].
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Catheterization; Coronary Angiography; Coronary Ar | 1977 |
Letter: Spasm and operative cholangiography.
Topics: Ampulla of Vater; Cholangiography; Diagnostic Techniques, Surgical; Humans; Nitroglycerin; Spasm; Sp | 1975 |
[The provocation of coronary spasm in man by ergonovine maleate. Angiographic demonstration (author's transl)].
Topics: Angiocardiography; Coronary Disease; Ergonovine; Humans; Nitroglycerin; Spasm | 1976 |
A new aspect of coronary artery spasm induced by cardiac surgery.
Topics: Adult; Cardiac Surgical Procedures; Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Dilti | 1991 |
Entrapment of venous catheter following inferior vena caval spasm.
Topics: Cardiac Catheterization; Child; Foreign Bodies; Humans; Male; Nitroglycerin; Spasm; Tetralogy of Fal | 1989 |
[Disorders of esophageal motility as a cause of retrosternal pain].
Topics: Adult; Diagnosis, Differential; Esophageal Diseases; Esophagitis, Peptic; Female; Gastrointestinal M | 1986 |
[Arterial vasospasm as a complication of the prevention of thromboembolism with heparin-dihydroergotamine and its treatment].
Topics: Adolescent; Adult; Dihydroergotamine; Drug Combinations; Femoral Fractures; Foot; Fracture Fixation, | 1986 |
Vasodilator drug effects on internal mammary artery and saphenous vein grafts.
Topics: Animals; Coronary Circulation; Dogs; Ferricyanides; Humans; Mammary Arteries; Nitroglycerin; Nitropr | 1988 |
Bilateral upper extremity ischemia after administration of dihydroergotamine-heparin for prophylaxis of deep venous thrombosis.
Topics: Arm; Brachial Artery; Dihydroergotamine; Drug Combinations; Female; Heparin; Heparin, Low-Molecular- | 1988 |
Clinical and manometric effects of nitroglycerin in diffuse esophageal spasm.
Topics: Adult; Deglutition Disorders; Esophageal Diseases; Esophagus; Humans; Male; Manometry; Muscle, Smoot | 1973 |
Variant angina pectoris caused by coronary artery spasm.
Topics: Angina Pectoris; Arteries; Cardiac Catheterization; Coronary Angiography; Coronary Artery Bypass; Co | 1974 |
Right coronary arterial spasm causing Prinzmetal's variant angina.
Topics: Adult; Angina Pectoris; Arteriosclerosis; Coronary Angiography; Coronary Disease; Humans; Isosorbide | 1974 |
Coronary hypertonia and angina.
Topics: Angina Pectoris; Arteries; Coronary Vessels; Electrocardiography; Humans; Lactates; Male; Middle Age | 1974 |
Letter: Venospasm during cardiac catheterization.
Topics: Administration, Oral; Cardiac Catheterization; Humans; Nitroglycerin; Spasm; Venous Insufficiency | 1974 |
Letter: The action of nitroglycerin.
Topics: Acute Disease; Coronary Vessels; Drug Therapy, Combination; Humans; Methoxamine; Myocardial Infarcti | 1974 |
Variant angina associated with angiographically demonstrated coronary artery spasm and REM sleep.
Topics: Adult; Affective Symptoms; Angina Pectoris; Angiocardiography; Coronary Disease; Electrocardiography | 1973 |
Coronary arterial spasm.
Topics: Adult; Angina Pectoris; Catheterization; Cineangiography; Coronary Angiography; Coronary Disease; De | 1968 |
[The effect of pharmacologic agents coronary circulation in experimental spasms of heart vessels].
Topics: Animals; Blood Circulation; Cats; Coronary Vessels; Methods; Morphine; Nitroglycerin; Papaverine; Ph | 1963 |
Diffuse esophageal spasm.
Topics: Diagnosis, Differential; Diet Therapy; Esophageal Achalasia; Esophageal Diseases; Humans; Kymography | 1970 |
Direct observations of the canine sphincter of Oddi.
Topics: Ampulla of Vater; Amyl Nitrite; Animals; Dogs; Dopamine; Ethanol; Fats; Hydrochloric Acid; Isoproter | 1971 |