nitroglycerin has been researched along with Sepsis in 8 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the context of a strict resuscitation protocol, based upon fulfillment of systemic hemodynamic end points in patients with early-phase severe sepsis or septic shock, we conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow." | 9.14 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. ( Bakker, AJ; Boerma, EC; Bruins, N; Buter, H; Egbers, PH; Gerritsen, RT; Ince, C; Kaiferova, K; Kingma, WP; Koetsier, PM; Konijn, A; Koopmans, M; Kuiper, MA; van Roon, EN, 2010) |
| " In contrast, no significant reduction in nitroglycerine-induced vascular relaxation was seen in rats with sepsis irrespective of pentoxifylline treatment." | 7.69 | Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis. ( Ba, ZF; Chaudry, IH; Wang, P; Wood, TJ, 1996) |
| "In the context of a strict resuscitation protocol, based upon fulfillment of systemic hemodynamic end points in patients with early-phase severe sepsis or septic shock, we conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow." | 5.14 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. ( Bakker, AJ; Boerma, EC; Bruins, N; Buter, H; Egbers, PH; Gerritsen, RT; Ince, C; Kaiferova, K; Kingma, WP; Koetsier, PM; Konijn, A; Koopmans, M; Kuiper, MA; van Roon, EN, 2010) |
| " In contrast, no significant reduction in nitroglycerine-induced vascular relaxation was seen in rats with sepsis irrespective of pentoxifylline treatment." | 3.69 | Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis. ( Ba, ZF; Chaudry, IH; Wang, P; Wood, TJ, 1996) |
| " Dose-response relaxation curves were determined for acetylcholine (ACh; 10(-8) to 10(-5) M), which stimulates endothelial nitric oxide production, and for nitroglycerine (10(-9) to 10(-6) M), which directly provides nitric oxide in vivo." | 1.29 | A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis. ( Chaudry, IH; Morrison, AM; Wang, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cox, LA | 1 |
| van Eijk, LT | 1 |
| Ramakers, BP | 1 |
| Dorresteijn, MJ | 1 |
| Gerretsen, J | 1 |
| Kox, M | 1 |
| Pickkers, P | 1 |
| Boerma, EC | 1 |
| Koopmans, M | 1 |
| Konijn, A | 1 |
| Kaiferova, K | 1 |
| Bakker, AJ | 1 |
| van Roon, EN | 1 |
| Buter, H | 1 |
| Bruins, N | 1 |
| Egbers, PH | 1 |
| Gerritsen, RT | 1 |
| Koetsier, PM | 1 |
| Kingma, WP | 1 |
| Kuiper, MA | 1 |
| Ince, C | 2 |
| Spronk, PE | 1 |
| Rommes, JH | 1 |
| Schaar, C | 1 |
| Dungel, P | 1 |
| Mittermayr, R | 1 |
| Haindl, S | 1 |
| Osipov, A | 1 |
| Wagner, C | 1 |
| Redl, H | 1 |
| Kozlov, AV | 1 |
| Wang, P | 4 |
| Ba, ZF | 3 |
| Chaudry, IH | 4 |
| Wood, TJ | 2 |
| Zhou, M | 1 |
| Morrison, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Evaluation of the Effect of Nitroglycerine Versus Placebo on the Microcirculation by Means of SDF Imaging in Septic Patients on the ICU[NCT00493415] | Phase 3 | 70 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nitroglycerin and Sepsis
| Article | Year |
|---|---|
Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo.
Topics: Adult; Blood Flow Velocity; Endothelium, Vascular; Endotoxemia; Forearm; Healthy Volunteers; Humans; | 2015 |
Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial.
Topics: Administration, Sublingual; Adult; Aged; Blood Flow Velocity; Cause of Death; Critical Care; Dose-Re | 2010 |
6 other studies available for nitroglycerin and Sepsis
| Article | Year |
|---|---|
Thrombolysis in fulminant purpura: observations on changes in microcirculatory perfusion during successful treatment.
Topics: Ear; Fibrinolytic Agents; Humans; IgA Vasculitis; Ketanserin; Male; Microcirculation; Middle Aged; N | 2006 |
Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate.
Topics: Animals; Cell Respiration; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Light; Male | 2008 |
Nitric oxide. To block or enhance its production during sepsis?
Topics: Acetylcholine; Animals; Aorta, Thoracic; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitr | 1994 |
Inhibition of the biologic activity of tumor necrosis factor maintains vascular endothelial cell function during hyperdynamic sepsis.
Topics: Acetylcholine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 1996 |
Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Endothelium, Vascular; Heart Rate; Male; Nitroglyceri | 1996 |
A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis.
Topics: Acetylcholine; Animals; Anticoagulants; Aorta; Cecum; Endothelium, Vascular; Heparin, Low-Molecular- | 1996 |