nitroglycerin has been researched along with Sclerosis, Systemic in 13 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma." | 2.84 | Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate. ( Dinsdale, G; Herrick, AL; Hughes, M; Manning, J; Moore, T; Murray, A; Roberts, C; Wilkinson, J, 2017) |
| "The pathogenesis of systemic sclerosis (SSc) includes vasculopathy with endothelial dysfunction." | 1.34 | Endothelial dysfunction precedes atherosclerosis in systemic sclerosis--relevance for prevention of vascular complications. ( Dér, H; Kerekes, G; Shoenfeld, Y; Soltész, P; Szamosi, S; Szegedi, G; Szekanecz, Z; Szucs, G; Tímár, O, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Pintea Bentea, G | 1 |
| Wauters, A | 1 |
| Wautrecht, JC | 1 |
| Cogan, E | 1 |
| Hughes, M | 1 |
| Moore, T | 1 |
| Manning, J | 1 |
| Wilkinson, J | 1 |
| Dinsdale, G | 1 |
| Roberts, C | 1 |
| Murray, A | 1 |
| Herrick, AL | 3 |
| Vinogradov, AA | 1 |
| Shilkina, NP | 1 |
| Kostyreva, NA | 1 |
| Szabolcsi, O | 1 |
| Nagy-Toldi, A | 1 |
| Zeher, M | 1 |
| Végh, J | 1 |
| Karoli, NA | 1 |
| Orlova, EE | 1 |
| Rebrov, AP | 1 |
| Szucs, G | 1 |
| Tímár, O | 1 |
| Szekanecz, Z | 1 |
| Dér, H | 1 |
| Kerekes, G | 1 |
| Szamosi, S | 1 |
| Shoenfeld, Y | 1 |
| Szegedi, G | 1 |
| Soltész, P | 1 |
| Gush, RJ | 1 |
| Tully, M | 1 |
| Jayson, MI | 2 |
| Aikimbaev, KS | 1 |
| Oğuz, M | 1 |
| Ozbek, S | 1 |
| Demirtaş, M | 1 |
| Birand, A | 1 |
| Batyraliev, T | 1 |
| Marczin, N | 1 |
| Riedel, B | 1 |
| Royston, D | 1 |
| Yacoub, M | 1 |
| Shinohara, T | 1 |
| Yanai, H | 1 |
| Hidaka, T | 1 |
| Suzuki, K | 1 |
| Ohsuzu, F | 1 |
| Kan, C | 1 |
| Akimoto, S | 1 |
| Abe, M | 1 |
| Okada, K | 1 |
| Ishikawa, O | 1 |
| Anderson, ME | 1 |
| Moore, TL | 1 |
| Hollis, S | 1 |
| King, TA | 1 |
| Ahmad, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.[NCT02801305] | Phase 2 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for nitroglycerin and Sclerosis, Systemic
| Article | Year |
|---|---|
Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate.
Topics: Administration, Cutaneous; Adult; Aged; Blood Flow Velocity; Cross-Over Studies; Double-Blind Method | 2017 |
A controlled trial of the effect of topical glyceryl trinitrate on skin blood flow and skin elasticity in scleroderma.
Topics: Administration, Topical; Adult; Aged; Double-Blind Method; Elasticity; Female; Humans; Male; Middle | 1994 |
Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis.
Topics: Administration, Topical; Adult; Aged; Female; Fingers; Humans; Laser-Doppler Flowmetry; Male; Microc | 2002 |
10 other studies available for nitroglycerin and Sclerosis, Systemic
| Article | Year |
|---|---|
Laser Doppler imaging evaluation of nitroglycerin patch application in systemic sclerosis patients.
Topics: Administration, Cutaneous; Blood Flow Velocity; Case-Control Studies; Cold Temperature; Female; Hand | 2020 |
[Brachial artery responsiveness in patients with systemic lupus erythematosus and scleroderma systematica].
Topics: Adult; Brachial Artery; Endothelium, Vascular; Humans; Lupus Erythematosus, Systemic; Middle Aged; N | 2010 |
[Systemic sclerosis in a patient suffering from breast cancer].
Topics: Adult; Amlodipine; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Duct | 2012 |
[Endothelial dysfunction in patients with scleroderma systemic].
Topics: Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Male | 2006 |
Endothelial dysfunction precedes atherosclerosis in systemic sclerosis--relevance for prevention of vascular complications.
Topics: Adult; Age Factors; Aged; Atherosclerosis; Brachial Artery; Carotid Artery, Common; Endothelium, Vas | 2007 |
Comparative assessment of the effects of vasodilators on peripheral vascular reactivity in patients with systemic scleroderma and Raynaud's phenomenon: color Doppler flow imaging study.
Topics: Adult; Captopril; Cold Temperature; Female; Fingers; Humans; Male; Nifedipine; Nitroglycerin; Pulsat | 1996 |
Exhaled nitric oxide and pulmonary response to iloprost in systemic sclerosis.
Topics: Airway Resistance; Capillaries; Humans; Iloprost; Infusions, Intravenous; Lung; Nitric Oxide; Nitrog | 1998 |
Acute congestive heart failure associated with a limited form of systemic sclerosis and primary biliary cirrhosis.
Topics: Acute Disease; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Centromere; Coronary Circu | 2001 |
Preliminary thermographic evaluation of new nitroglycerine tape on the peripheral circulatory disturbance in systemic sclerosis.
Topics: Administration, Cutaneous; Adult; Aged; Case-Control Studies; Drug Delivery Systems; Female; Fingers | 2002 |
Scleroderma and impotence: response to nitroglycerin applied to the fingers and penis.
Topics: Adult; Erectile Dysfunction; Fingers; Humans; Male; Nitroglycerin; Penis; Scleroderma, Systemic; Ski | 1990 |