nitroglycerin has been researched along with Scleroderma, Systemic in 13 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma." | 2.84 | Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate. ( Dinsdale, G; Herrick, AL; Hughes, M; Manning, J; Moore, T; Murray, A; Roberts, C; Wilkinson, J, 2017) |
| "The pathogenesis of systemic sclerosis (SSc) includes vasculopathy with endothelial dysfunction." | 1.34 | Endothelial dysfunction precedes atherosclerosis in systemic sclerosis--relevance for prevention of vascular complications. ( Dér, H; Kerekes, G; Shoenfeld, Y; Soltész, P; Szamosi, S; Szegedi, G; Szekanecz, Z; Szucs, G; Tímár, O, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Pintea Bentea, G | 1 |
| Wauters, A | 1 |
| Wautrecht, JC | 1 |
| Cogan, E | 1 |
| Hughes, M | 1 |
| Moore, T | 1 |
| Manning, J | 1 |
| Wilkinson, J | 1 |
| Dinsdale, G | 1 |
| Roberts, C | 1 |
| Murray, A | 1 |
| Herrick, AL | 3 |
| Vinogradov, AA | 1 |
| Shilkina, NP | 1 |
| Kostyreva, NA | 1 |
| Szabolcsi, O | 1 |
| Nagy-Toldi, A | 1 |
| Zeher, M | 1 |
| Végh, J | 1 |
| Karoli, NA | 1 |
| Orlova, EE | 1 |
| Rebrov, AP | 1 |
| Szucs, G | 1 |
| Tímár, O | 1 |
| Szekanecz, Z | 1 |
| Dér, H | 1 |
| Kerekes, G | 1 |
| Szamosi, S | 1 |
| Shoenfeld, Y | 1 |
| Szegedi, G | 1 |
| Soltész, P | 1 |
| Gush, RJ | 1 |
| Tully, M | 1 |
| Jayson, MI | 2 |
| Aikimbaev, KS | 1 |
| Oğuz, M | 1 |
| Ozbek, S | 1 |
| Demirtaş, M | 1 |
| Birand, A | 1 |
| Batyraliev, T | 1 |
| Marczin, N | 1 |
| Riedel, B | 1 |
| Royston, D | 1 |
| Yacoub, M | 1 |
| Shinohara, T | 1 |
| Yanai, H | 1 |
| Hidaka, T | 1 |
| Suzuki, K | 1 |
| Ohsuzu, F | 1 |
| Kan, C | 1 |
| Akimoto, S | 1 |
| Abe, M | 1 |
| Okada, K | 1 |
| Ishikawa, O | 1 |
| Anderson, ME | 1 |
| Moore, TL | 1 |
| Hollis, S | 1 |
| King, TA | 1 |
| Ahmad, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.[NCT02801305] | Phase 2 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for nitroglycerin and Scleroderma, Systemic
| Article | Year |
|---|---|
Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate.
Topics: Administration, Cutaneous; Adult; Aged; Blood Flow Velocity; Cross-Over Studies; Double-Blind Method | 2017 |
A controlled trial of the effect of topical glyceryl trinitrate on skin blood flow and skin elasticity in scleroderma.
Topics: Administration, Topical; Adult; Aged; Double-Blind Method; Elasticity; Female; Humans; Male; Middle | 1994 |
Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis.
Topics: Administration, Topical; Adult; Aged; Female; Fingers; Humans; Laser-Doppler Flowmetry; Male; Microc | 2002 |
10 other studies available for nitroglycerin and Scleroderma, Systemic
| Article | Year |
|---|---|
Laser Doppler imaging evaluation of nitroglycerin patch application in systemic sclerosis patients.
Topics: Administration, Cutaneous; Blood Flow Velocity; Case-Control Studies; Cold Temperature; Female; Hand | 2020 |
[Brachial artery responsiveness in patients with systemic lupus erythematosus and scleroderma systematica].
Topics: Adult; Brachial Artery; Endothelium, Vascular; Humans; Lupus Erythematosus, Systemic; Middle Aged; N | 2010 |
[Systemic sclerosis in a patient suffering from breast cancer].
Topics: Adult; Amlodipine; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Duct | 2012 |
[Endothelial dysfunction in patients with scleroderma systemic].
Topics: Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Male | 2006 |
Endothelial dysfunction precedes atherosclerosis in systemic sclerosis--relevance for prevention of vascular complications.
Topics: Adult; Age Factors; Aged; Atherosclerosis; Brachial Artery; Carotid Artery, Common; Endothelium, Vas | 2007 |
Comparative assessment of the effects of vasodilators on peripheral vascular reactivity in patients with systemic scleroderma and Raynaud's phenomenon: color Doppler flow imaging study.
Topics: Adult; Captopril; Cold Temperature; Female; Fingers; Humans; Male; Nifedipine; Nitroglycerin; Pulsat | 1996 |
Exhaled nitric oxide and pulmonary response to iloprost in systemic sclerosis.
Topics: Airway Resistance; Capillaries; Humans; Iloprost; Infusions, Intravenous; Lung; Nitric Oxide; Nitrog | 1998 |
Acute congestive heart failure associated with a limited form of systemic sclerosis and primary biliary cirrhosis.
Topics: Acute Disease; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Centromere; Coronary Circu | 2001 |
Preliminary thermographic evaluation of new nitroglycerine tape on the peripheral circulatory disturbance in systemic sclerosis.
Topics: Administration, Cutaneous; Adult; Aged; Case-Control Studies; Drug Delivery Systems; Female; Fingers | 2002 |
Scleroderma and impotence: response to nitroglycerin applied to the fingers and penis.
Topics: Adult; Erectile Dysfunction; Fingers; Humans; Male; Nitroglycerin; Penis; Scleroderma, Systemic; Ski | 1990 |