nitroglycerin and Reperfusion Injury studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

Excerpt	Relevance	Reference
"The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits."	7.73	Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. ( Khodosovskii, MN; Zinchuk, VV, 2006)
" This study was performed to assess the ultrastructural changes and to evaluate the protective effect of NO as donor nitroglycerin (NTG) treatment of ischemia-reperfusion injury in rat lungs."	7.72	Ultrastructural evaluation of the protective effect of nitroglycerin in preservation-reperfusion injury of rat lungs. ( Cho, CH; Jheon, SH; Kang, YN; Keum, DY; Kim, SP; Kwon, KY; Park, CK; Park, KK, 2004)
"Until two decades ago nitroglycerin was contraindicated in acute myocardial infarction (MI)."	6.17	Nitrates in myocardial infarction. ( Jugdutt, BI, 1994)
"Nitroglycerin (NTG) has been reported to possess preconditioning-like (PCL) protections on heart and other tissues."	5.35	Nitroglycerin protects small intestine from ischemia-reperfusion injury via NO-cGMP pathway and upregulation of alpha-CGRP. ( Dun, Y; Hao, Y; Li, J; Yang, C; Zhang, M; Zhang, Y, 2009)
"A warm ischemic period with concomitant reperfusion injury is a major limiting factor in the transplantation of lungs retrieved from NHBDs."	5.33	Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs. ( Egan, TM; Hoffmann, SC; Sadoff, JD; Schlidt, SA; Sevala, M, 2006)
"The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits."	3.73	Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. ( Khodosovskii, MN; Zinchuk, VV, 2006)
" This study was performed to assess the ultrastructural changes and to evaluate the protective effect of NO as donor nitroglycerin (NTG) treatment of ischemia-reperfusion injury in rat lungs."	3.72	Ultrastructural evaluation of the protective effect of nitroglycerin in preservation-reperfusion injury of rat lungs. ( Cho, CH; Jheon, SH; Kang, YN; Keum, DY; Kim, SP; Kwon, KY; Park, CK; Park, KK, 2004)
"Nitroglycerin has a favourable haemodynamic profile which promotes forward blood flow."	2.50	The effects of nitroglycerin during cardiopulmonary resuscitation. ( Stefaniotou, A; Varvarousi, G; Varvarousis, DP; Xanthos, T, 2014)
"Group 2 (T_D): 2 h testicular torsion was induced, afterward detorsion was performed and maintained for 2 h."	1.56	Nitroglycerin ameliorates sperm parameters, oxidative stress and testicular injury following by testicular torsion/detorsion in male rats. ( Davoodi, F; Farjanikish, G; Kheradmand, A; Raisi, A; Taheri, S, 2020)
"Nitroglycerin (NTG) has been reported to possess preconditioning-like (PCL) protections on heart and other tissues."	1.35	Nitroglycerin protects small intestine from ischemia-reperfusion injury via NO-cGMP pathway and upregulation of alpha-CGRP. ( Dun, Y; Hao, Y; Li, J; Yang, C; Zhang, M; Zhang, Y, 2009)
"Nitroglycerin (GTN) has been shown, in both human and animal studies, to induce a protective phenotype that limits tissue damage after ischemia and reperfusion."	1.35	The mechanism of nitrate-induced preconditioning. ( Di Stolfo, G; Dragoni, S; Forconi, S; Gori, T; Leone, MC; Lisi, M; Parker, JD, 2008)
" Superoxide decreases the bioavailability of nitric oxide (NO) via its reaction that yields peroxynitrite."	1.33	Endothelial dysfunction in trauma patients: a preliminary communication. ( Lang, JD; Mathru, M, 2005)
"A warm ischemic period with concomitant reperfusion injury is a major limiting factor in the transplantation of lungs retrieved from NHBDs."	1.33	Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs. ( Egan, TM; Hoffmann, SC; Sadoff, JD; Schlidt, SA; Sevala, M, 2006)
"Ischemia-reperfusion injury is a serious clinical situation which can cause serious morbidity and mortality."	1.33	Role of glyceryl trinitrate, a nitric oxide donor, in the renal ischemia-reperfusion injury of rats. ( Akyol, H; Bingul, S; Colak, E; Gul, AE; Kaptanoglu, L; Kucuk, HF; Kurt, N; Ozalp, F; Torlak, OA, 2006)
"Reperfusion injury is a perplexing cause of early graft failure after lung transplantation and today we know that reperfusion may be more harmful to tissues than the preceding ischemia."	1.33	Beneficial effects of supplemental nitric oxide donor given during reperfusion period in reperfusion-induced lung injury. ( Demirel, R; Dilek, FH; Esme, H; Fidan, H; Solak, O; Unlu, M, 2006)
"Reperfusion induced pulmonary edema in the NTG- group, but not in the NTG+ group."	1.31	Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury. ( Bando, T; Hitomi, S; Isowa, N; Kawashima, M; Liu, M; Nakamura, T; Toyokuni, S; Wada, H, 2000)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (26.67)	18.2507
2000's	22 (48.89)	29.6817
2010's	10 (22.22)	24.3611
2020's	1 (2.22)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double - Blind, Placebo - Controlled Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction of the Forearm Vasculature in Healthy Male Subjects[NCT05217654]	Phase 1	32 participants (Anticipated)	Interventional	2022-02-18	Recruiting
Adenosine Receptor Involvement in Acute Ischemic Preconditioning of the Vascular Endothelium[NCT00184847]		8 participants (Anticipated)	Interventional	2005-03-31	Suspended
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury[NCT00987974]	Phase 4	48 participants (Anticipated)	Interventional	2009-09-30	Completed
Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty: A Pilot Randomized Control Trial[NCT02406131]		40 participants (Anticipated)	Interventional	2018-04-30	Suspended (stopped due to logistic issues - no available scans for participants at the moment need to postponed starting dates)
A Clinical Study Investigating Ischemic Preconditioning in Type II Diabetic Patients Undergoing Coronary Artery Bypass Graft Surgery.[NCT00397163]	Phase 1	200 participants (Anticipated)	Interventional	2010-12-31	Completed
A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062]		21 participants (Actual)	Interventional	2015-07-31	Completed
Pilot Study for the Development of Transient Forearm Endothelial Dysfunction[NCT00453531]	Phase 1/Phase 2	6 participants (Actual)	Interventional	2007-03-26	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
The effects of nitroglycerin during cardiopulmonary resuscitation. European journal of pharmacology, 2014, Jul-05, Volume: 734 Topics: Animals; Cardiopulmonary Resuscitation; Humans; Neuroprotective Agents; Nitroglycerin; Reperfusion I	2014
Nitrates in myocardial infarction. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:4 Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Tolera	1994

Article	Year
Repeated daily dosing with sildenafil provides sustained protection from endothelial dysfunction caused by ischemia and reperfusion: a human in vivo study. American journal of physiology. Heart and circulatory physiology, 2014, Sep-15, Volume: 307, Issue:6 Topics: Administration, Cutaneous; Adolescent; Adult; Biomarkers; Drug Administration Schedule; Endothelium,	2014
Tolerance to nitroglycerin-induced preconditioning of the endothelium: a human in vivo study. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2 Topics: Acetylcholine; Administration, Cutaneous; Adult; Antioxidants; Ascorbic Acid; Dose-Response Relation	2010
Chronic protection against ischemia and reperfusion-induced endothelial dysfunction during therapy with different organic nitrates. Clinical research in cardiology : official journal of the German Cardiac Society, 2012, Volume: 101, Issue:6 Topics: Adult; Aldehyde Dehydrogenase; Analysis of Variance; Cells, Cultured; Drug Administration Schedule;	2012
Nitroglycerin protects the endothelium from ischaemia and reperfusion: human mechanistic insight. British journal of clinical pharmacology, 2007, Volume: 64, Issue:2 Topics: Adult; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Mitochondrial Membrane	2007
Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:9 Topics: Adult; Double-Blind Method; Endothelium, Vascular; Humans; Ischemic Preconditioning; Isosorbide Dini	2007
Nitrates in myocardial infarction. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:4 Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Tolera	1994
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001
Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation, 2001, Mar-27, Volume: 103, Issue:12 Topics: Acetylcholine; Adult; Blood Flow Velocity; Dose-Response Relationship, Drug; Endothelium, Vascular;	2001

Article	Year
Nitroglycerin ameliorates sperm parameters, oxidative stress and testicular injury following by testicular torsion/detorsion in male rats. Experimental and molecular pathology, 2020, Volume: 117 Topics: Animals; Antioxidants; Apoptosis; Catalase; Glutathione Peroxidase; Humans; Male; Malondialdehyde; N	2020
In Utero Exposure to Alcohol Impairs Reactivity of Cerebral Arterioles and Increases Susceptibility of the Brain to Damage Following Ischemia/Reperfusion in Adulthood. Alcoholism, clinical and experimental research, 2019, Volume: 43, Issue:4 Topics: Acetophenones; Adenosine Diphosphate; Animals; Arterioles; Brain; Enzyme Inhibitors; Ethanol; Excita	2019
Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats. Drug research, 2019, Volume: 69, Issue:11 Topics: Acute Kidney Injury; Animals; Antioxidants; Creatinine; Electrolytes; Kidney; Lipid Peroxidation; Ma	2019
[Effect of verapamil and nitroglycerin on transplanted lung function in canines]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2014, Volume: 39, Issue:8 Topics: Animals; Blood Gas Analysis; Dogs; Hemodynamics; Lung; Lung Transplantation; Nitroglycerin; Organ Pr	2014
Nitroglycerin protects small intestine from ischemia-reperfusion injury via NO-cGMP pathway and upregulation of alpha-CGRP. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009, Volume: 13, Issue:3 Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic GMP; Guanylate Cyclase; Intestine, Small	2009
Combining cariporide with glyceryl trinitrate optimizes cardiac preservation during porcine heart transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009, Volume: 9, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Disaccharides; Electrolytes; Glutamates; Glutathione;	2009
Nitroglycerin-induced preconditioning: interaction with nitrate tolerance. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2 Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug	2010
Hypothermic machine perfusion ameliorates ischemia-reperfusion injury in rat lungs from non-heart-beating donors. Transplantation, 2011, Oct-27, Volume: 92, Issue:8 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; Hypothermia, Induced; Lung; Lung Transplantati	2011
Reconditioning of lungs donated after circulatory death with normothermic ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2012, Volume: 31, Issue:2 Topics: Adenosine Triphosphate; Animals; Bucladesine; Dogs; Lung; Lung Transplantation; Models, Animal; Nitr	2012
Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. The Journal of surgical research, 2003, Volume: 114, Issue:1 Topics: Administration, Topical; Animals; Bile; Hemodynamics; Intestinal Diseases; Intestinal Mucosa; Intest	2003
Continuous infusion of nitroglycerin improves pulmonary graft function of non-heart-beating donor lungs. Transplantation, 2004, Jun-27, Volume: 77, Issue:12 Topics: Animals; Heart Arrest; Infusions, Intravenous; Lung; Lung Transplantation; Microscopy, Electron, Sca	2004
Ultrastructural evaluation of the protective effect of nitroglycerin in preservation-reperfusion injury of rat lungs. Transplantation proceedings, 2004, Volume: 36, Issue:7 Topics: Animals; Edema; Lung; Nitroglycerin; Organ Preservation; Pulmonary Alveoli; Rats; Rats, Sprague-Dawl	2004
Exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass--response to acetylcholine and nitroglycerin. British journal of anaesthesia, 2005, Volume: 94, Issue:2 Topics: Acetylcholine; Aged; Aged, 80 and over; Biomarkers; Breath Tests; Cardiac Surgical Procedures; Cardi	2005
Improved preservation of the rat heart with celsior solution supplemented with cariporide plus glyceryl trinitrate. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:8 Topics: Animals; Aorta; Blood Flow Velocity; Cardiac Output; Cold Temperature; Cryopreservation; Disaccharid	2005
Endothelial dysfunction in trauma patients: a preliminary communication. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3 Topics: Adult; Body Mass Index; Endothelium, Vascular; Female; Hemodynamics; Humans; Male; Middle Aged; Nitr	2005
Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, Volume: 25, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Cyclic GMP; Death; Enzyme Activation; Guanylate Cycla	2006
Role of glyceryl trinitrate, a nitric oxide donor, in the renal ischemia-reperfusion injury of rats. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2006, Volume: 38, Issue:5 Topics: Animals; Blood Urea Nitrogen; Creatine; Glomerular Filtration Rate; Kidney; Nitric Oxide; Nitric Oxi	2006
[Nitroglycerin tolerance aggravates arterial ischemia/reperfusion injury by increasing nitrotyrosine and ONOO- production]. Zhonghua xin xue guan bing za zhi, 2006, Volume: 34, Issue:8 Topics: Animals; Aorta; Drug Tolerance; Glutathione; In Vitro Techniques; Male; Nitroglycerin; Rats; Rats, S	2006
Beneficial effects of supplemental nitric oxide donor given during reperfusion period in reperfusion-induced lung injury. The Thoracic and cardiovascular surgeon, 2006, Volume: 54, Issue:7 Topics: Analysis of Variance; Animals; Heart-Lung Transplantation; Lung; Lung Transplantation; Neutrophils;	2006
Glyceryl trinitrate inhibits hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for preeclampsia. The American journal of pathology, 2007, Volume: 170, Issue:3 Topics: Aldehydes; Apoptosis; Blotting, Western; Caspase 3; Collagen Type XI; Female; Humans; Hypoxia; Immun	2007
Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:6 Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Aspartate Aminotransferases; Ischemia	2006
Dynamics of nitroglycerin-induced exhaled nitric oxide after lung transplantation: evidence of pulmonary microvascular injury? The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:12 Topics: Adult; Case-Control Studies; Coronary Artery Bypass; Exhalation; Female; Humans; Infusions, Intraven	2007
The mechanism of nitrate-induced preconditioning. Clinical hemorheology and microcirculation, 2008, Volume: 39, Issue:1-4 Topics: Endothelium, Vascular; Equipment Design; Free Radicals; Humans; Ischemic Preconditioning; Mitochondr	2008
Comparative study on the effects of intracoronary nicorandil and nitroglycerin in ischaemic, reperfused porcine hearts. European heart journal, 1995, Volume: 16, Issue:5 Topics: Animals; Female; Hemodynamics; Injections, Intra-Arterial; Male; Niacinamide; Nicorandil; Nitroglyce	1995
Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathione S-transferase and lipid peroxidation. Japanese journal of pharmacology, 1994, Volume: 65, Issue:3 Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase;	1994
Nitroglycerin maintains graft vascular homeostasis and enhances preservation in an orthotopic rat lung transplant model. The Journal of thoracic and cardiovascular surgery, 1995, Volume: 109, Issue:2 Topics: Animals; Graft Survival; Homeostasis; Isotonic Solutions; Lung Transplantation; Male; Nitroglycerin;	1995
Effect of endotoxin-enhanced hepatic reperfusion injury on endothelium-dependent relaxation in rat aorta. Shock (Augusta, Ga.), 1996, Volume: 6, Issue:2 Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Bacterial Toxins; Constriction; Disease Model	1996
Glyceryl trinitrate prevents neutrophil activation but not thromboxane release following ischaemia-reperfusion injury. The British journal of surgery, 1996, Volume: 83, Issue:8 Topics: Animals; Aortic Diseases; Arterial Occlusive Diseases; Blood Pressure; Leukocyte Count; Lung; Male;	1996
Attenuation of lung graft reperfusion injury by a nitric oxide donor. The Journal of thoracic and cardiovascular surgery, 1997, Volume: 113, Issue:2 Topics: Animals; Cardioplegic Solutions; Disease Models, Animal; Disease Progression; Hemodynamics; Hydralaz	1997
Glyceryl trinitrate prevents neutrophil activation but not thromboxane release following ischaemia-reperfusion injury. The British journal of surgery, 1997, Volume: 84, Issue:1 Topics: Humans; Neutrophil Activation; Nitric Oxide; Nitroglycerin; Reperfusion Injury; Thromboxanes	1997
Relative susceptibility of endothelium and myocardial cells to ischaemia-reperfusion injury. Acta physiologica Scandinavica, 1997, Volume: 161, Issue:1 Topics: Animals; Aorta; Coronary Vessels; Endothelium, Vascular; Hypothermia, Induced; Male; Muscle Fibers,	1997
Nitroglycerine reduces neutrophil activation and acute damage in latissimus dorsi muscle grafts. The Annals of thoracic surgery, 1998, Volume: 66, Issue:6 Topics: Animals; Cardiomyoplasty; Endothelium, Vascular; Intraoperative Care; Male; Neutrophil Activation; N	1998
Cytoprotective effects of nitroglycerin in ischemia-reperfusion-induced lung injury. American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:3 Pt 1 Topics: Animals; Cyclic GMP; DNA Damage; Immunoenzyme Techniques; Lung; Lung Transplantation; Male; Nitrogly	2000
Nitroglycerin alters alveolar type II cell ultrastructure after ischemia and reperfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2001, Volume: 20, Issue:8 Topics: Animals; Cell Survival; Disaccharides; Electrolytes; Epithelium; Glutamates; Glutathione; Histidine;	2001
[Changes of the responses of arterioles to noradrenaline, acetylcholine and nitroglycerin after limb ischemia-reperfusion]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2000, Volume: 14, Issue:3 Topics: Acetylcholine; Animals; Arterioles; Female; Hindlimb; Male; Nitroglycerin; Norepinephrine; Rabbits;	2000
Ischaemic endothelial dysfunction after single or multidose cardioplegia. European heart journal, 1992, Volume: 13, Issue:7 Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Coronary Dise	1992
The effect of prostacyclin as a constituent of a preservation solution in protecting lungs from ischemic injury because of its vasodilatory properties. Transplantation, 1990, Volume: 49, Issue:4 Topics: Animals; Epoprostenol; Lung; Nitroglycerin; Organ Preservation; Rats; Rats, Inbred Strains; Reperfus	1990

nitroglycerin and Reperfusion Injury

Research Excerpts

Research

Studies (45)

Authors

Clinical Trials (7)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Raisi, A	1
Kheradmand, A	1
Farjanikish, G	1
Davoodi, F	1
Taheri, S	1
Cananzi, SG	1
Mayhan, WG	1
Ahmadi, F	1
Hajihashemi, S	1
Rahbari, A	1
Ghanbari, F	1
Stefaniotou, A	1
Varvarousi, G	1
Varvarousis, DP	1
Xanthos, T	1
McLaughlin, K	1
Lytvyn, Y	1
Luca, MC	3
Liuni, A	3
Gori, T	6
Parker, JD	6
Jiang, Z	1
Hu, P	1
Liu, J	1
Wang, D	1
Jin, L	1
Hong, C	1
Li, J	1
Zhang, M	1
Yang, C	1
Dun, Y	1
Zhang, Y	1
Hao, Y	1
Hing, AJ	1
Watson, A	1
Hicks, M	2
Gao, L	2
Faddy, SC	1
McMahon, AC	1
Kesteven, SH	1
Wilson, MK	1
Jansz, P	1
Feneley, MP	1
Macdonald, PS	2
Dragoni, S	5
Di Stolfo, G	4
Sicuro, S	2
Thomas, G	1
Oelze, M	2
Daiber, A	2
Csont, T	1
Nakajima, D	2
Chen, F	2
Yamada, T	2
Sakamoto, J	2
Osumi, A	1
Fujinaga, T	1
Shoji, T	1
Sakai, H	1
Bando, T	3
Date, H	2
Lisi, M	4
Steven, S	1
Stalleicken, D	1
Münzel, T	1
Laghi-Pasini, F	1
Ohsumi, A	1
Khanna, A	1
Rossman, J	1
Caty, MG	1
Fung, HL	1
Loehe, F	1
Preissler, G	1
Annecke, T	1
Bittmann, I	1
Jauch, KW	1
Messmer, K	1
Kwon, KY	1
Cho, CH	1
Kang, YN	1
Kim, SP	1
Park, KK	1
Keum, DY	1
Park, CK	1
Jheon, SH	1
Törnberg, DC	1
Angdin, M	1
Settergen, G	1
Liska, J	1
Lundberg, JO	1
Weitzberg, E	1
Mathru, M	1
Lang, JD	1
Egan, TM	1
Hoffmann, SC	1
Sevala, M	1
Sadoff, JD	1
Schlidt, SA	1
Kucuk, HF	1
Kaptanoglu, L	1
Ozalp, F	1
Kurt, N	1
Bingul, S	1
Torlak, OA	1
Colak, E	1
Akyol, H	1
Gul, AE	1
Fan, Q	1
Zhang, L	1
Gao, F	1
Ma, XL	1
Cao, XB	1
Yang, XC	1
Esme, H	1
Fidan, H	1
Solak, O	1
Dilek, FH	1
Demirel, R	1
Unlu, M	1
Belkacemi, L	1
Bainbridge, SA	1
Dickinson, MA	1
Smith, GN	1
Graham, CH	1
Forconi, S	2
Khodosovskii, MN	1
Zinchuk, VV	1
Pautz, A	1
Kleinert, H	1
Gal, J	1
Kovesi, T	1
Royston, D	1
Marczin, N	1
Leone, MC	1
Klein, HH	1
Pich, S	1
Lindert-Heimberg, S	1
Schade-Brittinger, C	1
Maisch, B	1
Nebendahl, K	1
Naito, A	1
Aniya, Y	1
Sakanashi, M	1
Jugdutt, BI	1
Naka, Y	1
Chowdhury, NC	1
Oz, MC	1
Smith, CR	1
Yano, OJ	1
Michler, RE	1
Stern, DM	1
Pinsky, DJ	1
McKenna, R	1
Laskey, RE	1
Wang, Y	1
Jaeschke, H	1
Mathews, WR	1
Barry, MC	1
Kelly, CJ	1
Stokes, K	1
Abdih, H	1
Sheehan, S	1
Burke, P	1
Bouchier Hayes, D	1
Bhabra, MS	1
Hopkinson, DN	1
Shaw, TE	1
Hooper, TL	2
Clark, S	1
Mankad, PS	2
Amrani, M	1
Rothery, S	1
Severs, NJ	1
Yacoub, MH	2
Tang, AT	1
Geraghty, P	1
Dascombe, MJ	1
Jarvis, JC	1
Salmons, S	1
Kawashima, M	1
Nakamura, T	1
Isowa, N	1
Liu, M	1
Toyokuni, S	1
Hitomi, S	1
Wada, H	1
Kharbanda, RK	1
Peters, M	1
Walton, B	1
Kattenhorn, M	1
Mullen, M	1
Klein, N	1
Vallance, P	1
Deanfield, J	1
MacAllister, R	1
Fehrenbach, A	1
Wittwer, T	1
Meyer, D	1
von Vietinghoff, S	1
Viehöver, M	1
Fehrenbach, H	1
Richter, J	1
Wahlers, T	1
Xing, X	1
Li, JH	1
Guo, ET	1
Chester, AH	1
Mulvin, D	1
Jones, K	1
Howard, R	1
Grosso, M	1
Repine, J	1
Johnston, M	1