nitroglycerin has been researched along with Raynaud Disease in 38 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical nitroglycerin has been tried for the alleviation of Raynaud's phenomenon in rheumatic diseases, but its effect is not widely recognized." | 5.07 | [Nitroglycerin tape for Raynaud's phenomenon of rheumatic disease patients--an evaluation of skin temperature by thermography]. ( Akama, T; Kashiwagi, H; Natsuda, H; Shibui, Y; Suzuki, H; Yamane, K; Yuhara, T, 1994) |
| "In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma." | 2.84 | Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate. ( Dinsdale, G; Herrick, AL; Hughes, M; Manning, J; Moore, T; Murray, A; Roberts, C; Wilkinson, J, 2017) |
| " However, these different dosage forms are not all equal in terms of safety and efficacy, and not every one is commercially available for use in clinical practice." | 2.58 | Use of nitroglycerin ointment to treat primary and secondary Raynaud's phenomenon: a systematic literature review. ( Chan, T; Cruz, JE; Hermes-DeSantis, ER; Luen, M; Qiu, O, 2018) |
| "Limited systemic sclerosis, including CREST syndrome, manifests as fibrotic skin changes restricted to the hands and face, with vascular, musculoskeletal, and visceral involvement." | 1.48 | Botulinum toxin for treatment of Raynaud phenomenon in CREST syndrome. ( Berk-Krauss, J; Christman, MP; Franks, A; Liebman, TN; Sicco, KL, 2018) |
| "The current treatment options for Raynaud phenomenon are often ineffective and can have undesirable adverse effects." | 1.35 | Therapy: A local approach to Raynaud phenomenon. ( Herrick, AL, 2009) |
| "Thermal hyperemia is dramatically altered in patients with secondary RP in comparison with subjects with primary RP." | 1.33 | Local hyperemia to heating is impaired in secondary Raynaud's phenomenon. ( Boignard, A; Carpentier, PH; Cracowski, JL; Duc, C; Grange, L; Minson, CT; Salvat-Melis, M; Sarrot-Reynauld, F, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (42.11) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 6 (15.79) | 29.6817 |
| 2010's | 8 (21.05) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, PO | 1 |
| Drobek, HH | 1 |
| Porwolik, M | 1 |
| Pietrauszka, K | 1 |
| Miziołek, B | 1 |
| Bergler-Czop, B | 1 |
| Brzezińska-Wcisło, L | 1 |
| Qiu, O | 1 |
| Chan, T | 1 |
| Luen, M | 1 |
| Cruz, JE | 1 |
| Hermes-DeSantis, ER | 1 |
| Berk-Krauss, J | 1 |
| Christman, MP | 1 |
| Franks, A | 1 |
| Sicco, KL | 1 |
| Liebman, TN | 1 |
| Poredos, P | 2 |
| Hughes, M | 1 |
| Moore, T | 2 |
| Manning, J | 2 |
| Wilkinson, J | 1 |
| Dinsdale, G | 1 |
| Roberts, C | 1 |
| Murray, A | 1 |
| Herrick, AL | 3 |
| LUND, F | 1 |
| FOX, MJ | 1 |
| LESLIE, CL | 1 |
| Chung, L | 1 |
| Shapiro, L | 1 |
| Fiorentino, D | 1 |
| Baron, M | 1 |
| Shanahan, J | 1 |
| Sule, S | 1 |
| Hsu, V | 1 |
| Rothfield, N | 1 |
| Steen, V | 1 |
| Martin, RW | 1 |
| Smith, E | 1 |
| Mayes, M | 1 |
| Simms, R | 1 |
| Pope, J | 1 |
| Kahaleh, B | 1 |
| Csuka, ME | 1 |
| Gruber, B | 1 |
| Collier, D | 1 |
| Sweiss, N | 1 |
| Gilbert, A | 1 |
| Dechow, FJ | 2 |
| Gregory, J | 2 |
| Wigley, FM | 2 |
| Gargh, K | 1 |
| Baildam, EM | 1 |
| Cleary, GA | 1 |
| Beresford, MW | 1 |
| McCann, LJ | 1 |
| Donegani, E | 1 |
| Takáts, A | 1 |
| Garai, I | 1 |
| Papp, G | 1 |
| Hevér, T | 1 |
| Csiki, E | 1 |
| András, C | 1 |
| Csiki, Z | 1 |
| Hummers, LK | 1 |
| Dugowson, CE | 1 |
| Wise, RA | 1 |
| Michalek, J | 1 |
| Yenokyan, G | 1 |
| McGready, J | 1 |
| Klein-Weigel, P | 1 |
| Krall, K | 1 |
| Falkensammer, J | 1 |
| Heinz-Erian, P | 1 |
| Ulmer, H | 1 |
| Fraedrich, G | 1 |
| KLECKNER, MS | 1 |
| ALLEN, EV | 2 |
| WAKIM, KG | 2 |
| KLECKNER, M | 1 |
| Boignard, A | 1 |
| Salvat-Melis, M | 1 |
| Carpentier, PH | 1 |
| Minson, CT | 1 |
| Grange, L | 1 |
| Duc, C | 1 |
| Sarrot-Reynauld, F | 1 |
| Cracowski, JL | 1 |
| Franks, AG | 1 |
| Peterson, LL | 1 |
| Vorhies, C | 1 |
| Grenholm, R | 1 |
| Itoh, F | 1 |
| Teh, LS | 1 |
| Tully, MP | 1 |
| O'Reilly, D | 1 |
| Jayson, MI | 2 |
| Singh, S | 1 |
| De Trafford, JC | 1 |
| Baskerville, PA | 1 |
| Martin, JF | 1 |
| Natsuda, H | 1 |
| Shibui, Y | 1 |
| Yuhara, T | 1 |
| Akama, T | 1 |
| Suzuki, H | 1 |
| Yamane, K | 1 |
| Kashiwagi, H | 1 |
| Aikimbaev, KS | 1 |
| Oğuz, M | 1 |
| Ozbek, S | 1 |
| Demirtaş, M | 1 |
| Birand, A | 1 |
| Batyraliev, T | 1 |
| Piérard, GE | 1 |
| Shinohara, T | 1 |
| Yanai, H | 1 |
| Hidaka, T | 1 |
| Suzuki, K | 1 |
| Ohsuzu, F | 1 |
| Anderson, ME | 1 |
| Moore, TL | 1 |
| Hollis, S | 1 |
| King, TA | 1 |
| Allegra, C | 1 |
| Pollari, G | 1 |
| Beaucher, WN | 1 |
| Coffman, JD | 1 |
| Hänsgen, K | 1 |
| Podhaisky, H | 1 |
| Sternitzky, R | 1 |
| Nilsson, H | 1 |
| Nahir, AM | 1 |
| Schapira, D | 1 |
| Scharf, Y | 1 |
| Coppock, JS | 1 |
| Hardman, JM | 1 |
| Bacon, PA | 1 |
| Woods, KL | 1 |
| Kendall, MJ | 1 |
| Fischer, M | 1 |
| Reinhold, B | 1 |
| Falck, H | 1 |
| Török, M | 1 |
| Alexander, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study to Investigate the Effect of Cocoa Flavanols on Symptoms in Primary Raynaud's Phenomenon[NCT03815162] | 27 participants (Actual) | Interventional | 2018-10-16 | Completed | |||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.[NCT02801305] | Phase 2 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nitroglycerin and Raynaud Disease
| Article | Year |
|---|---|
Drug Treatment of Raynaud's Phenomenon of the Nipple.
Topics: Breast Diseases; Breast Feeding; Calcium Channel Blockers; Female; Humans; Nifedipine; Nipples; Nitr | 2020 |
What is the Best Way to Treat Patients with Raynaud's Phenomenon and a Tendency towards Hypotension?
Topics: Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypotension; Losartan; Nifedipine; Nitrog | 2020 |
Use of nitroglycerin ointment to treat primary and secondary Raynaud's phenomenon: a systematic literature review.
Topics: Administration, Cutaneous; Humans; Microcirculation; Nitroglycerin; Ointments; Raynaud Disease; Trea | 2018 |
Raynaud's Syndrome: a neglected disease.
Topics: Calcium Channel Blockers; Epoprostenol; Humans; Iloprost; Ischemia; Life Style; Neglected Diseases; | 2016 |
[Raynaud's syndrome, 2011].
Topics: Adrenergic alpha-Antagonists; Angiography; Angiotensin-Converting Enzyme Inhibitors; Body Temperatur | 2012 |
[How I treat...Raynaud's phenomenon].
Topics: Calcium Channel Blockers; Humans; Nitroglycerin; Raynaud Disease; Vasodilator Agents | 1998 |
Pharmacological treatment of Raynaud's phenomenon with special reference to calcium-entry blockers.
Topics: Adrenergic alpha-Antagonists; Alprostadil; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel | 1986 |
11 trials available for nitroglycerin and Raynaud Disease
| Article | Year |
|---|---|
Reduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate.
Topics: Administration, Cutaneous; Adult; Aged; Blood Flow Velocity; Cross-Over Studies; Double-Blind Method | 2017 |
MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud's phenomenon: a randomized, controlled trial.
Topics: Administration, Topical; Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitroglyceri | 2009 |
A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon.
Topics: Administration, Cutaneous; Adult; Aged; Chemistry, Pharmaceutical; Cross-Over Studies; Dose-Response | 2013 |
Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease.
Topics: Administration, Topical; Adult; Clinical Trials as Topic; Collagen Diseases; Double-Blind Method; Fe | 1982 |
Sustained-release transdermal glyceryl trinitrate patches as a treatment for primary and secondary Raynaud's phenomenon.
Topics: Administration, Cutaneous; Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Doubl | 1995 |
[Nitroglycerin tape for Raynaud's phenomenon of rheumatic disease patients--an evaluation of skin temperature by thermography].
Topics: Administration, Cutaneous; Adult; Aged; Female; Humans; Male; Middle Aged; Nitroglycerin; Raynaud Di | 1994 |
Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis.
Topics: Administration, Topical; Adult; Aged; Female; Fingers; Humans; Laser-Doppler Flowmetry; Male; Microc | 2002 |
Pharmacological treatment of Raynaud's phenomenon with special reference to calcium-entry blockers.
Topics: Adrenergic alpha-Antagonists; Alprostadil; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel | 1986 |
Double-blind randomized trial of nitroderm TTS in the treatment of Raynaud's phenomenon.
Topics: Administration, Topical; Adult; Double-Blind Method; Drug Evaluation; Female; Humans; Middle Aged; N | 1986 |
Objective relief of vasospasm by glyceryl trinitrate in secondary Raynaud's phenomenon.
Topics: Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Fingers; Humans; Nitroglycerin; Rayna | 1986 |
Topical nitroglycerin ointment in Raynaud's phenomenon.
Topics: Administration, Topical; Adult; Aged; Cardiac Output; Double-Blind Method; Female; Fingers; Hemodyna | 1985 |
21 other studies available for nitroglycerin and Raynaud Disease
| Article | Year |
|---|---|
Botulinum toxin for treatment of Raynaud phenomenon in CREST syndrome.
Topics: Acetylcholine Release Inhibitors; Administration, Topical; Aged; Botulinum Toxins; CREST Syndrome; D | 2018 |
Percutaneous nitroglycerin treatment in cases of peripheral circulatory disorders, especially Raynaud's disease.
Topics: Administration, Cutaneous; Cardiovascular Diseases; Humans; Nitroglycerin; Raynaud Disease | 1948 |
Treatment of Raynaud's diseases with nitroglycerine.
Topics: Humans; Nitroglycerin; Raynaud Disease | 1948 |
Therapy: A local approach to Raynaud phenomenon.
Topics: Administration, Topical; Emulsions; Fingers; Hemodynamics; Humans; Microcirculation; Nitroglycerin; | 2009 |
A retrospective clinical analysis of pharmacological modalities used for symptomatic relief of Raynaud's phenomenon in children treated in a UK paediatric rheumatology centre.
Topics: Administration, Cutaneous; Adolescent; Calcium Channel Blockers; Child; Child, Preschool; Delayed-Ac | 2010 |
[Nitrates at high altitude, that is the inappropriate use of a drug].
Topics: Administration, Cutaneous; Altitude Sickness; Angina Pectoris; Brain Edema; Disorders of Excessive S | 2011 |
Lack of seasonal variation in flow-mediated dilatation of the brachial artery in women with primary Raynaud's phenomenon and healthy controls.
Topics: Adult; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Female; Fingers; Humans; Nitrogl | 2003 |
[RHEOGRAPHIC INDICES OF THE INTENSITY OF THE BLOOD CIRCULATION IN THE EXTREMITIES].
Topics: Blood Circulation; Dogs; Electrocardiography; Extremities; Nitroglycerin; Plethysmography; Plethysmo | 1963 |
The use of glyceryl trinitrate (nitroglycerin) ointment in the treatment of Raynaud's diseases and Raynaud's phenomenon.
Topics: Humans; Nitroglycerin; Raynaud Disease | 1950 |
The effect of local application of glyceryl trinitrate (nitroglycerine) on Raynaud's disease and Raynaud's phenomenon; studies on blood flow and clinical manifestations.
Topics: Hemodynamics; Humans; Nitroglycerin; Raynaud Disease | 1951 |
Local hyperemia to heating is impaired in secondary Raynaud's phenomenon.
Topics: Adult; Cell Count; Cohort Studies; Endothelium, Vascular; Female; Fingers; Hot Temperature; Humans; | 2005 |
Raynaud's syndrome. Treatment with sublingual administration of nitroglycerin, swinging arm maneuver, and biofeedback training.
Topics: Adult; Aged; Arm; Biofeedback, Psychology; Female; Humans; Male; Middle Aged; Movement; Nitroglyceri | 1983 |
[Nitroglycerin ointment for numb hands].
Topics: Female; Humans; Middle Aged; Nitroglycerin; Ointments; Raynaud Disease | 1983 |
A rheoencephalographic study of the cerebral blood flow in patients with the vibration disease.
Topics: Adult; Age Factors; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Nitroglycerin; P | 1983 |
Response of digital arteries to endothelium dependent and independent vasodilators in patients with Raynaud's phenomenon.
Topics: Acetylcholine; Adult; Arginine; Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; E | 1995 |
Comparative assessment of the effects of vasodilators on peripheral vascular reactivity in patients with systemic scleroderma and Raynaud's phenomenon: color Doppler flow imaging study.
Topics: Adult; Captopril; Cold Temperature; Female; Fingers; Humans; Male; Nifedipine; Nitroglycerin; Pulsat | 1996 |
Acute congestive heart failure associated with a limited form of systemic sclerosis and primary biliary cirrhosis.
Topics: Acute Disease; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Centromere; Coronary Circu | 2001 |
Aimed pharmacological treatment of Raynaud's disease.
Topics: Adult; Benzyl Compounds; Dihydroergotoxine; Ethanolamines; Female; Hand; Humans; Middle Aged; Nitrog | 1979 |
Vasodilator drugs for peripheral vascular disease.
Topics: Humans; Nitroglycerin; Ointments; Prazosin; Quinazolines; Raynaud Disease | 1979 |
Vasodilator drugs for peripheral vascular disease.
Topics: Griseofulvin; Humans; Nitroglycerin; Prazosin; Quinazolines; Raynaud Disease | 1979 |
[Effect of nitroglycerin on finger artery blood pressure].
Topics: Adult; Blood Pressure; Female; Fingers; Humans; Ischemia; Male; Middle Aged; Nitroglycerin; Raynaud | 1991 |