nitroglycerin has been researched along with Placenta, Retained in 19 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Placenta, Retained: A placenta that fails to be expelled after BIRTH of the FETUS. A PLACENTA is retained when the UTERUS fails to contract after the delivery of its content, or when the placenta is abnormally attached to the MYOMETRIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nitroglycerin administration was not associated with an increase in headaches (RR 1." | 4.91 | Nitroglycerin for management of retained placenta. ( Abdel-Aleem, H; Abdel-Aleem, MA; Shaaban, OM, 2015) |
| "Currently, the only effective treatments for a retained placenta are the surgical procedures of manual removal of placenta (MROP) and uterine curettage, which are not universally available, particularly in low- and middle-income countries." | 2.90 | Nitroglycerin for treatment of retained placenta: A randomised, placebo-controlled, multicentre, double-blind trial in the UK. ( Brewin, J; Carruthers, KF; Chua, GN; Denison, FC; Hallowell, N; Hudson, J; Lawton, J; McPherson, G; Norman, JE; Norrie, J; Peace, M; Scotland, G, 2019) |
| "The only way to treat a retained placenta is for a trained doctor to remove it by an operation in theatre." | 2.90 | Glyceryl trinitrate to reduce the need for manual removal of retained placenta following vaginal delivery: the GOT-IT RCT. ( Brewin, J; Brook-Smith, S; Carruthers, KF; Chua, GN; Clarkson, C; Denison, FC; Hallowell, N; Hudson, J; Lawton, J; McPherson, G; Norman, JE; Norrie, J; Peace, M; Scotland, G, 2019) |
| "A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby." | 2.84 | A pragmatic group sequential, placebo-controlled, randomised trial to determine the effectiveness of glyceryl trinitrate for retained placenta (GOT-IT): a study protocol. ( Brewin, J; Brook-Smith, S; Carruthers, KF; Clarkson, C; Denison, FC; Forrest, M; Hallowell, N; Hodges, L; Hudson, J; Lawton, J; McDonald, A; McPherson, GC; Morrow, S; Norman, JE; Norrie, J; Peace, M; Scotland, G, 2017) |
| "The rates of successful removal of the retained placenta in the study (n=20) and control (n=20) groups were compared, as were blood pressure, pulse rate, blood loss, and adverse effects." | 2.76 | Intravenous nitroglycerin for controlled cord traction in the management of retained placenta. ( Permpolprasert, L; Prechapanich, J; Suksopee, P; Suwanvichai, S; Visalyaputra, S; Yimyam, S, 2011) |
| "A common approach in the management of retained placenta is administration of oxytocin followed by controlled cord traction." | 2.73 | Sublingual nitroglycerin seems to be effective in the management of retained placenta. ( Bullarbo, M; Ekerhovd, E, 2008) |
| "Sublingual nitroglycerin for treatment of retained placenta seems to be effective without causing serious adverse effects." | 2.71 | Sublingual nitroglycerin for management of retained placenta. ( Bullarbo, M; Ekerhovd, E; Tjugum, J, 2005) |
| "Retained placenta affects 0." | 2.47 | Tocolysis for management of retained placenta. ( Abdel-Aleem, H; Abdel-Aleem, MA; Shaaban, OM, 2011) |
| "A nitroglycerin tablet was used to relax the lower uterine segment and cervix, which allowed the placenta to pass through the cervix for delivery." | 1.39 | A novel treatment for management of a trapped placenta using intracervical nitroglycerin tablets. ( Gray, R; Pasternak, A; Rodgers, BC, 2013) |
| "The incidence and importance of retained placenta (RP) varies greatly around the world." | 1.35 | The retained placenta. ( Weeks, AD, 2008) |
| "Postpartum haemorrhage due to retained placenta is one of the commonest life-threatening conditions during the third stage of labour." | 1.32 | Intravenous nitro-glycerine versus general anaesthesia for placental extraction--a sequential comparison. ( Chiu, JW; Jha, S; Yeo, IS, 2003) |
| "Nitroglycerin (NTG) has been demonstrated to provide uterine relaxation in the management of various obstetric complications." | 1.29 | Alternating nitroglycerin and syntocinon to facilitate uterine exploration and removal of an adherent placenta. ( Ananthanarayan, C; Chan, AS; Rolbin, SH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denison, FC | 3 |
| Carruthers, KF | 3 |
| Hudson, J | 3 |
| McPherson, G | 2 |
| Chua, GN | 2 |
| Peace, M | 3 |
| Brewin, J | 3 |
| Hallowell, N | 3 |
| Scotland, G | 3 |
| Lawton, J | 3 |
| Norrie, J | 3 |
| Norman, JE | 3 |
| Brook-Smith, S | 2 |
| Clarkson, C | 2 |
| McPherson, GC | 1 |
| McDonald, A | 1 |
| Forrest, M | 1 |
| Morrow, S | 1 |
| Hodges, L | 1 |
| Rodgers, BC | 1 |
| Pasternak, A | 1 |
| Gray, R | 1 |
| Duffy, JM | 1 |
| Wilson, MJ | 1 |
| Khan, KS | 1 |
| Abdel-Aleem, H | 2 |
| Abdel-Aleem, MA | 2 |
| Shaaban, OM | 2 |
| Kashanian, M | 1 |
| Hasankhani, S | 1 |
| Sheikhansari, N | 1 |
| Bahasadri, S | 1 |
| Homam, H | 1 |
| Weeks, AD | 1 |
| Visalyaputra, S | 1 |
| Prechapanich, J | 1 |
| Suwanvichai, S | 1 |
| Yimyam, S | 1 |
| Permpolprasert, L | 1 |
| Suksopee, P | 1 |
| Jha, S | 1 |
| Chiu, JW | 1 |
| Yeo, IS | 1 |
| Chedraui, PA | 1 |
| Insuasti, DF | 1 |
| Bullarbo, M | 2 |
| Tjugum, J | 1 |
| Ekerhovd, E | 2 |
| Chan, AS | 1 |
| Ananthanarayan, C | 1 |
| Rolbin, SH | 1 |
| Lowenwirt, IP | 1 |
| Zauk, RM | 1 |
| Handwerker, SM | 1 |
| Dufour, P | 1 |
| Vinatier, D | 1 |
| Puech, F | 1 |
| Axemo, P | 1 |
| Fu, X | 1 |
| Lindberg, B | 1 |
| Ulmsten, U | 1 |
| Wessén, A | 1 |
| Harnett, MJ | 1 |
| Segal, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| GOT-IT Trial: A Pragmatic Group Sequential Placebo Controlled Randomised Trial to Determine the Effectiveness of Glyceryl Trinitrate for Retained Placenta.[NCT02085213] | Phase 4 | 1,107 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Maternal Outcomes Following Manual Lysis of the Placenta After Fifteen Compared to Thirty Minutes. A Randomized Controlled Trial.[NCT03626844] | 100 participants (Anticipated) | Interventional | 2018-11-20 | Suspended (stopped due to Insufficient resources.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nitroglycerin and Placenta, Retained
| Article | Year |
|---|---|
What is the optimal pharmacological management of retained placenta?
Topics: Drug Administration Routes; Drug Therapy, Combination; Female; Humans; Nitroglycerin; Oxytocics; Oxy | 2014 |
Nitroglycerin for management of retained placenta.
Topics: Administration, Sublingual; Female; Headache; Humans; Nitroglycerin; Oxytocics; Oxytocin; Placenta, | 2015 |
Tocolysis for management of retained placenta.
Topics: Administration, Sublingual; Female; Humans; Nitroglycerin; Oxytocics; Oxytocin; Placenta, Retained; | 2011 |
The use of intravenous nitroglycerin for cervico-uterine relaxation: a review of the literature.
Topics: Breech Presentation; Cervix Uteri; Cesarean Section; Female; Humans; Infusions, Intravenous; Muscle | 1997 |
7 trials available for nitroglycerin and Placenta, Retained
| Article | Year |
|---|---|
Nitroglycerin for treatment of retained placenta: A randomised, placebo-controlled, multicentre, double-blind trial in the UK.
Topics: Administration, Sublingual; Adult; Cost-Benefit Analysis; Delivery, Obstetric; Double-Blind Method; | 2019 |
Glyceryl trinitrate to reduce the need for manual removal of retained placenta following vaginal delivery: the GOT-IT RCT.
Topics: Administration, Sublingual; Adolescent; Adult; Blood Transfusion; Cost-Benefit Analysis; Double-Blin | 2019 |
A pragmatic group sequential, placebo-controlled, randomised trial to determine the effectiveness of glyceryl trinitrate for retained placenta (GOT-IT): a study protocol.
Topics: Administration, Sublingual; Blood Volume; Cost Savings; Cost-Benefit Analysis; Double-Blind Method; | 2017 |
The effects of sequential use of oxytocin and sublingual nitroglycerin in the cases of retained placenta.
Topics: Administration, Sublingual; Adult; Female; Humans; Nitroglycerin; Oxytocics; Oxytocin; Placenta, Ret | 2016 |
Intravenous nitroglycerin for controlled cord traction in the management of retained placenta.
Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Injections, Intravenous; Nitroglycerin; Placenta, | 2011 |
Sublingual nitroglycerin for management of retained placenta.
Topics: Administration, Sublingual; Adult; Blood Pressure; Delivery, Obstetric; Double-Blind Method; Female; | 2005 |
Sublingual nitroglycerin seems to be effective in the management of retained placenta.
Topics: Administration, Sublingual; Adult; Drug Therapy, Combination; Female; Humans; Injections, Intramuscu | 2008 |
8 other studies available for nitroglycerin and Placenta, Retained
| Article | Year |
|---|---|
A novel treatment for management of a trapped placenta using intracervical nitroglycerin tablets.
Topics: Administration, Intravaginal; Adult; Female; Humans; Nitroglycerin; Placenta, Retained; Pregnancy; T | 2013 |
The retained placenta.
Topics: Female; Humans; Labor Stage, Third; Nitroglycerin; Oxytocics; Oxytocin; Placenta, Retained; Pregnanc | 2008 |
Intravenous nitro-glycerine versus general anaesthesia for placental extraction--a sequential comparison.
Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Fentanyl; Hemodynami | 2003 |
Intravenous nitroglycerin in the management of retained placenta.
Topics: Adult; Blood Pressure; Female; Humans; Nitroglycerin; Placenta, Retained; Pregnancy; Pulse | 2003 |
Alternating nitroglycerin and syntocinon to facilitate uterine exploration and removal of an adherent placenta.
Topics: Adult; Blood Pressure; Calcium; Ephedrine; Female; Humans; Infusions, Intravenous; Myosins; Nitrogly | 1995 |
Safety of intravenous glyceryl trinitrate in management of retained placenta.
Topics: Adult; Analgesia, Obstetrical; Female; Hemodynamics; Humans; Injections, Intravenous; Nitroglycerin; | 1997 |
Intravenous nitroglycerin for rapid uterine relaxation.
Topics: Cesarean Section; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Injections, | 1998 |
Presence of placental tissue is necessary for TNG to provide uterine relaxation.
Topics: Adult; Delivery, Obstetric; Female; Humans; Nitroglycerin; Oxytocics; Oxytocin; Placenta; Placenta, | 2000 |