nitroglycerin has been researched along with Obesity in 35 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " No difference was found in the dose-response curves among these 3 groups (P >." | 5.31 | Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats. ( Fung, HL; Wang, EQ, 2002) |
| " As a result of the proposed method of treatment had improved the clinical course of CCH due to lower body weight, body mass index (BMI) and abdominal obesity indexes (AOI), which were characterized by decreasing the duration and frequency of angina attacks, reducing the number of nitroglycerin tablets taken, and also increased exercise tolerance (ET)." | 3.79 | [Оptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity]. ( Teslenko, IuV, 2013) |
| "Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis." | 2.73 | Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. ( Gutterman, DD; Hoffmann, RG; Jurva, JW; Kulinski, JP; Phillips, SA; Pleuss, J; Syed, AQ, 2008) |
| "Although menopause was not associated with vascular impairment, short-term improvement in vascular function was observed in those using menopausal hormonal therapy." | 1.91 | Effect of menopause and age on vascular impairment. ( Aittokallio, J; Hautajärvi, T; Heinonen, O; Kalleinen, N; Polo, O; Raitakari, O; Riskumäki, M; Saaresranta, T; Vahlberg, T, 2023) |
| "Thus, type II diabetes mellitus impairs nitric oxide synthase-dependent responses of cerebral arterioles." | 1.32 | Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats. ( Mayhan, WG; Schwaninger, RM; Sun, H, 2003) |
| "Obesity has been reported to be associated with coronary artery disease and other atherosclerotic diseases." | 1.30 | The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. ( Akishita, M; Ako, J; Eto, M; Hashimoto, M; Kozaki, K; Ouchi, Y; Sugimoto, N; Toba, K; Yoshizumi, M, 1998) |
| "Based on our results, as coronary atherosclerosis becomes more severe, the adjusted brachial artery FMD becomes more severely impaired." | 1.30 | The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery. ( Arai, Y; Hirase, H; Kaku, B; Mizuno, S; Moriuchi, I; Murakami, T; Nagata, M; Nio, Y; Ohnaka, M; Ohsato, K; Takahashi, Y, 1998) |
| " Identical dose-response curves were produced by PGF2 alpha in arteries from OH and LN dogs." | 1.29 | Decreased potency of contraction to alpha-adrenoceptor stimulation in renal arteries from obese hypertensive dogs. ( Granger, JP; Ratz, PH; West, DB, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.00) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 16 (45.71) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Aittokallio, J | 1 |
| Saaresranta, T | 1 |
| Riskumäki, M | 1 |
| Hautajärvi, T | 1 |
| Vahlberg, T | 1 |
| Polo, O | 1 |
| Heinonen, O | 1 |
| Raitakari, O | 1 |
| Kalleinen, N | 1 |
| Teslenko, IuV | 1 |
| Takahashi, F | 1 |
| Goto, M | 1 |
| Wada, Y | 1 |
| Hasebe, N | 1 |
| Rajendran, S | 1 |
| Willoughby, SR | 1 |
| Chan, WP | 1 |
| Liberts, EA | 1 |
| Heresztyn, T | 1 |
| Saha, M | 1 |
| Marber, MS | 1 |
| Norman, RJ | 1 |
| Horowitz, JD | 1 |
| Chung, WB | 1 |
| Hamburg, NM | 1 |
| Holbrook, M | 1 |
| Shenouda, SM | 1 |
| Dohadwala, MM | 1 |
| Terry, DF | 1 |
| Gokce, N | 2 |
| Vita, JA | 2 |
| Peña, AS | 1 |
| Belobrajdic, DP | 1 |
| Wiltshire, E | 1 |
| Gent, R | 1 |
| Hirte, C | 1 |
| Couper, J | 1 |
| Chan, DC | 1 |
| Wong, AT | 1 |
| Yamashita, S | 1 |
| Watts, GF | 1 |
| Wang, EQ | 1 |
| Fung, HL | 1 |
| Hamdy, O | 1 |
| Ledbury, S | 1 |
| Mullooly, C | 1 |
| Jarema, C | 1 |
| Porter, S | 1 |
| Ovalle, K | 1 |
| Moussa, A | 1 |
| Caselli, A | 1 |
| Caballero, AE | 1 |
| Economides, PA | 1 |
| Veves, A | 1 |
| Horton, ES | 1 |
| Shimabukuro, M | 1 |
| Higa, N | 1 |
| Asahi, T | 1 |
| Oshiro, Y | 1 |
| Takasu, N | 1 |
| Tagawa, T | 1 |
| Ueda, S | 1 |
| Shimomura, I | 1 |
| Funahashi, T | 1 |
| Matsuzawa, Y | 1 |
| Anfossi, G | 2 |
| Russo, I | 1 |
| Massucco, P | 2 |
| Mattiello, L | 2 |
| Trovati, M | 2 |
| SCHWARTZ, W | 1 |
| Schwaninger, RM | 1 |
| Sun, H | 1 |
| Mayhan, WG | 1 |
| Kelly, AS | 1 |
| Wetzsteon, RJ | 1 |
| Kaiser, DR | 1 |
| Steinberger, J | 1 |
| Bank, AJ | 1 |
| Dengel, DR | 1 |
| McDonnell, M | 1 |
| Forse, AR | 1 |
| Istfan, N | 1 |
| Stoeckl, M | 1 |
| Lipinska, I | 1 |
| Keaney, JF | 1 |
| Apovian, CM | 1 |
| McErlane, K | 1 |
| Esposito, K | 1 |
| Ciotola, M | 1 |
| Schisano, B | 1 |
| Gualdiero, R | 1 |
| Sardelli, L | 1 |
| Misso, L | 1 |
| Giannetti, G | 1 |
| Giugliano, D | 1 |
| Fulop, T | 1 |
| Jebelovszki, E | 1 |
| Erdei, N | 1 |
| Szerafin, T | 1 |
| Forster, T | 1 |
| Edes, I | 1 |
| Koller, A | 1 |
| Bagi, Z | 1 |
| Phillips, SA | 1 |
| Jurva, JW | 1 |
| Syed, AQ | 2 |
| Kulinski, JP | 1 |
| Pleuss, J | 1 |
| Hoffmann, RG | 1 |
| Gutterman, DD | 1 |
| Aggoun, Y | 1 |
| Farpour-Lambert, NJ | 1 |
| Marchand, LM | 1 |
| Golay, E | 1 |
| Maggio, AB | 1 |
| Beghetti, M | 1 |
| Ratz, PH | 1 |
| West, DB | 1 |
| Granger, JP | 1 |
| Mularoni, EM | 1 |
| Burzacca, S | 1 |
| Ponziani, MC | 1 |
| Cavalot, F | 1 |
| Hashimoto, M | 1 |
| Akishita, M | 1 |
| Eto, M | 1 |
| Kozaki, K | 1 |
| Ako, J | 1 |
| Sugimoto, N | 1 |
| Yoshizumi, M | 1 |
| Toba, K | 1 |
| Ouchi, Y | 1 |
| Bülow, C | 1 |
| Harling, H | 1 |
| Kaku, B | 1 |
| Mizuno, S | 1 |
| Ohsato, K | 1 |
| Murakami, T | 1 |
| Moriuchi, I | 1 |
| Arai, Y | 1 |
| Nio, Y | 1 |
| Hirase, H | 1 |
| Nagata, M | 1 |
| Takahashi, Y | 1 |
| Ohnaka, M | 1 |
| Laight, DW | 1 |
| Kengatharan, KM | 1 |
| Gopaul, NK | 1 |
| Anggård, EE | 1 |
| Carrier, MJ | 1 |
| Arcaro, G | 1 |
| Zamboni, M | 1 |
| Rossi, L | 1 |
| Turcato, E | 1 |
| Covi, G | 1 |
| Armellini, F | 1 |
| Bosello, O | 1 |
| Lechi, A | 1 |
| Al Suwaidi, J | 1 |
| Higano, ST | 1 |
| Holmes, DR | 1 |
| Lennon, R | 1 |
| Lerman, A | 1 |
| Whalley, GA | 1 |
| Bagg, W | 1 |
| Doughty, RN | 1 |
| Gamble, G | 1 |
| Braatvedt, G | 1 |
| Sharpe, N | 1 |
| Hodgman, JR | 1 |
| Smirnov, VE | 1 |
| Wenger, R | 1 |
| Tempero, KF | 1 |
| Logue, RB | 1 |
| Robinson, PH | 1 |
| Miller, HC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relationship of Adiponectin in Adipose Tissue, Thy-1 in Plaques, and Inflammatory[NCT02519257] | 96 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity[NCT01821313] | 43 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| Effects of the Atkins Diet Versus a Low Fat Diet on Endothelial Function, Lipid Profiles, and Systemic Markers of Inflammation[NCT00993278] | Phase 3 | 60 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium[NCT01550315] | 27 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary analysis will involve a non-parametric, paired, Signed Rank test of flow mediated dilation (FMD) between all subjects (POTS & control subjects) on the high sodium diet vs low sodium diet (NCT01550315)
Timeframe: FMD was assessed on the morning of day 7, after 6 days of being on either a high salt diet or a low salt diet.
| Intervention | percentage of change (Mean) |
|---|---|
| High Sodium POTS | 12.75 |
| Low Sodium Diet POTS | 11.65 |
| High Sodium Controls | 11.43 |
| Low Sodium Controls | 12.75 |
1 review available for nitroglycerin and Obesity
| Article | Year |
|---|---|
Angina pectoris: diagnosis, evaluation and therapy.
Topics: Angina Pectoris; Angiography; Digitalis Glycosides; Ethanol; Female; Heart Function Tests; Humans; M | 1973 |
5 trials available for nitroglycerin and Obesity
| Article | Year |
|---|---|
Adiponectin relates to smooth muscle function and folate in obese children.
Topics: Adiponectin; Adolescent; Body Mass Index; Child; Cholesterol, LDL; Cross-Sectional Studies; Endothel | 2010 |
Apolipoprotein B-48 as a determinant of endothelial function in obese subjects with type 2 diabetes mellitus: effect of fenofibrate treatment.
Topics: Adult; Aged; Analysis of Variance; Apolipoprotein B-48; Apolipoprotein C-III; Brachial Artery; Chole | 2012 |
Hypoadiponectinemia is closely linked to endothelial dysfunction in man.
Topics: Adiponectin; Adult; Body Mass Index; Endothelium, Vascular; Fasting; Forearm; Humans; Intercellular | 2003 |
Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise.
Topics: Adolescent; Blood Glucose; Body Mass Index; C-Reactive Protein; Child; Cholesterol; Endothelium, Vas | 2004 |
Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity.
Topics: Adult; Blood Pressure; Brachial Artery; Diet, Carbohydrate-Restricted; Diet, Fat-Restricted; Endothe | 2008 |
29 other studies available for nitroglycerin and Obesity
| Article | Year |
|---|---|
Effect of menopause and age on vascular impairment.
Topics: Brachial Artery; Cardiovascular Diseases; Endothelium, Vascular; Female; Humans; Hypoxia; Menopause; | 2023 |
[Оptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity].
Topics: Adult; Aged; Angina, Stable; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Body Weight; | 2013 |
Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cal | 2015 |
Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects.
Topics: Adenosine Diphosphate; Adult; Albuterol; Arginine; Body Composition; C-Reactive Protein; Cohort Stud | 2009 |
The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors.
Topics: Adaptation, Physiological; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Atherosclerosis; | 2009 |
Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats.
Topics: Analysis of Variance; Animals; Male; Models, Animal; Nitroglycerin; Obesity; Rats; Rats, Sprague-Daw | 2002 |
Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome.
Topics: Blood Flow Velocity; Blood Pressure; Body Mass Index; Brachial Artery; Endothelium, Vascular; Exerci | 2003 |
Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.
Topics: Acetylcysteine; Adenosine Diphosphate; Adult; Amifostine; Antioxidants; Collagen; Cyclic GMP; Drug R | 2003 |
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates; | 1964 |
Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Blotting, Western; Cerebrovascular Circul | 2003 |
Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients.
Topics: Adult; Blood Glucose; Brachial Artery; Endothelium, Vascular; Female; Gastric Bypass; Humans; Male; | 2005 |
Keeping track of the patch: transdermal delivery in obese patients.
Topics: Administration, Cutaneous; Angina Pectoris; Diabetes Mellitus, Type 2; Female; Humans; Middle Aged; | 2005 |
Endothelial microparticles correlate with endothelial dysfunction in obese women.
Topics: Adult; Body Mass Index; Brachial Artery; Endothelial Cells; Endothelium; Female; Humans; Middle Aged | 2006 |
Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
Topics: Aged; Arterioles; Body Mass Index; Brachial Artery; Bradykinin; Coronary Vessels; Female; Humans; Hy | 2007 |
Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure.
Topics: Atherosclerosis; Blood Pressure; Brachial Artery; Carotid Artery Diseases; Carotid Artery, Common; C | 2008 |
Decreased potency of contraction to alpha-adrenoceptor stimulation in renal arteries from obese hypertensive dogs.
Topics: Animals; Dinoprost; Dogs; Endothelins; Female; Hypertension; In Vitro Techniques; Nitroglycerin; Obe | 1993 |
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Blood Glucose; Blood Platelets; Blood Pressure; | 1998 |
The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation.
Topics: Adipose Tissue; Adult; Blood Flow Velocity; Body Constitution; Body Mass Index; Brachial Artery; Cho | 1998 |
[Combined nitroglycerin-heparin infusion in mesenteric venous thrombosis].
Topics: Adult; Anticoagulants; Drug Combinations; Female; Heparin; Humans; Infusions, Intravenous; Intestine | 1998 |
The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery.
Topics: Adult; Aged; Angina, Unstable; Brachial Artery; Coronary Angiography; Coronary Artery Disease; Coron | 1998 |
Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo.
Topics: Acetylcholine; Animals; Antioxidants; Body Weight; Dietary Supplements; Drug Tolerance; Lipid Peroxi | 1998 |
Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity.
Topics: Adipose Tissue; Adult; Arteriosclerosis; Biomarkers; Blood Flow Velocity; Body Composition; Endothel | 1999 |
Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries.
Topics: Acetylcholine; Adenosine; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Analysis of | 2001 |
Pseudonormal diastolic filling unmasked with glyceryl trinitrate in patients with type 2 diabetes with poor metabolic control.
Topics: Biomarkers; Blood Glucose; Body Surface Area; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diastole | 2001 |
Modern medical management of angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Assisted Circulation; Coronary Angiography; Digitalis | 1975 |
[Rheoencephalographic method of of analyzing several risk factors for cerebrovascular disease (epidemiologic study)].
Topics: Adult; Age Factors; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Hypercho | 1977 |
[Possibilities in the prevention of myocardial infarct].
Topics: Adrenergic beta-Antagonists; Age Factors; Gymnastics; Humans; Hypertension; Myocardial Infarction; N | 1974 |
Medical management of angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Anticoagulants; Antidepressive Agents; Blood Pressure; | 1972 |
The medical and surgical treatment of angina pectoris.
Topics: Angina Pectoris; Epinephrine; Exercise Therapy; Humans; Nitroglycerin; Norepinephrine; Obesity; Smok | 1972 |