Page last updated: 2024-11-01

nitroglycerin and Obesity

nitroglycerin has been researched along with Obesity in 35 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
" No difference was found in the dose-response curves among these 3 groups (P >."5.31Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats. ( Fung, HL; Wang, EQ, 2002)
" As a result of the proposed method of treatment had improved the clinical course of CCH due to lower body weight, body mass index (BMI) and abdominal obesity indexes (AOI), which were characterized by decreasing the duration and frequency of angina attacks, reducing the number of nitroglycerin tablets taken, and also increased exercise tolerance (ET)."3.79[Оptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity]. ( Teslenko, IuV, 2013)
"Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis."2.73Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. ( Gutterman, DD; Hoffmann, RG; Jurva, JW; Kulinski, JP; Phillips, SA; Pleuss, J; Syed, AQ, 2008)
"Although menopause was not associated with vascular impairment, short-term improvement in vascular function was observed in those using menopausal hormonal therapy."1.91Effect of menopause and age on vascular impairment. ( Aittokallio, J; Hautajärvi, T; Heinonen, O; Kalleinen, N; Polo, O; Raitakari, O; Riskumäki, M; Saaresranta, T; Vahlberg, T, 2023)
"Thus, type II diabetes mellitus impairs nitric oxide synthase-dependent responses of cerebral arterioles."1.32Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats. ( Mayhan, WG; Schwaninger, RM; Sun, H, 2003)
"Obesity has been reported to be associated with coronary artery disease and other atherosclerotic diseases."1.30The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. ( Akishita, M; Ako, J; Eto, M; Hashimoto, M; Kozaki, K; Ouchi, Y; Sugimoto, N; Toba, K; Yoshizumi, M, 1998)
"Based on our results, as coronary atherosclerosis becomes more severe, the adjusted brachial artery FMD becomes more severely impaired."1.30The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery. ( Arai, Y; Hirase, H; Kaku, B; Mizuno, S; Moriuchi, I; Murakami, T; Nagata, M; Nio, Y; Ohnaka, M; Ohsato, K; Takahashi, Y, 1998)
" Identical dose-response curves were produced by PGF2 alpha in arteries from OH and LN dogs."1.29Decreased potency of contraction to alpha-adrenoceptor stimulation in renal arteries from obese hypertensive dogs. ( Granger, JP; Ratz, PH; West, DB, 1993)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19907 (20.00)18.7374
1990's7 (20.00)18.2507
2000's16 (45.71)29.6817
2010's4 (11.43)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Aittokallio, J1
Saaresranta, T1
Riskumäki, M1
Hautajärvi, T1
Vahlberg, T1
Polo, O1
Heinonen, O1
Raitakari, O1
Kalleinen, N1
Teslenko, IuV1
Takahashi, F1
Goto, M1
Wada, Y1
Hasebe, N1
Rajendran, S1
Willoughby, SR1
Chan, WP1
Liberts, EA1
Heresztyn, T1
Saha, M1
Marber, MS1
Norman, RJ1
Horowitz, JD1
Chung, WB1
Hamburg, NM1
Holbrook, M1
Shenouda, SM1
Dohadwala, MM1
Terry, DF1
Gokce, N2
Vita, JA2
Peña, AS1
Belobrajdic, DP1
Wiltshire, E1
Gent, R1
Hirte, C1
Couper, J1
Chan, DC1
Wong, AT1
Yamashita, S1
Watts, GF1
Wang, EQ1
Fung, HL1
Hamdy, O1
Ledbury, S1
Mullooly, C1
Jarema, C1
Porter, S1
Ovalle, K1
Moussa, A1
Caselli, A1
Caballero, AE1
Economides, PA1
Veves, A1
Horton, ES1
Shimabukuro, M1
Higa, N1
Asahi, T1
Oshiro, Y1
Takasu, N1
Tagawa, T1
Ueda, S1
Shimomura, I1
Funahashi, T1
Matsuzawa, Y1
Anfossi, G2
Russo, I1
Massucco, P2
Mattiello, L2
Trovati, M2
SCHWARTZ, W1
Schwaninger, RM1
Sun, H1
Mayhan, WG1
Kelly, AS1
Wetzsteon, RJ1
Kaiser, DR1
Steinberger, J1
Bank, AJ1
Dengel, DR1
McDonnell, M1
Forse, AR1
Istfan, N1
Stoeckl, M1
Lipinska, I1
Keaney, JF1
Apovian, CM1
McErlane, K1
Esposito, K1
Ciotola, M1
Schisano, B1
Gualdiero, R1
Sardelli, L1
Misso, L1
Giannetti, G1
Giugliano, D1
Fulop, T1
Jebelovszki, E1
Erdei, N1
Szerafin, T1
Forster, T1
Edes, I1
Koller, A1
Bagi, Z1
Phillips, SA1
Jurva, JW1
Syed, AQ2
Kulinski, JP1
Pleuss, J1
Hoffmann, RG1
Gutterman, DD1
Aggoun, Y1
Farpour-Lambert, NJ1
Marchand, LM1
Golay, E1
Maggio, AB1
Beghetti, M1
Ratz, PH1
West, DB1
Granger, JP1
Mularoni, EM1
Burzacca, S1
Ponziani, MC1
Cavalot, F1
Hashimoto, M1
Akishita, M1
Eto, M1
Kozaki, K1
Ako, J1
Sugimoto, N1
Yoshizumi, M1
Toba, K1
Ouchi, Y1
Bülow, C1
Harling, H1
Kaku, B1
Mizuno, S1
Ohsato, K1
Murakami, T1
Moriuchi, I1
Arai, Y1
Nio, Y1
Hirase, H1
Nagata, M1
Takahashi, Y1
Ohnaka, M1
Laight, DW1
Kengatharan, KM1
Gopaul, NK1
Anggård, EE1
Carrier, MJ1
Arcaro, G1
Zamboni, M1
Rossi, L1
Turcato, E1
Covi, G1
Armellini, F1
Bosello, O1
Lechi, A1
Al Suwaidi, J1
Higano, ST1
Holmes, DR1
Lennon, R1
Lerman, A1
Whalley, GA1
Bagg, W1
Doughty, RN1
Gamble, G1
Braatvedt, G1
Sharpe, N1
Hodgman, JR1
Smirnov, VE1
Wenger, R1
Tempero, KF1
Logue, RB1
Robinson, PH1
Miller, HC1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Relationship of Adiponectin in Adipose Tissue, Thy-1 in Plaques, and Inflammatory[NCT02519257]96 participants (Actual)Interventional2008-08-31Completed
Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity[NCT01821313]43 participants (Actual)Interventional2012-09-30Completed
Effects of the Atkins Diet Versus a Low Fat Diet on Endothelial Function, Lipid Profiles, and Systemic Markers of Inflammation[NCT00993278]Phase 360 participants (Actual)Interventional2008-08-31Completed
A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium[NCT01550315]27 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

FMD (% Change)

The primary analysis will involve a non-parametric, paired, Signed Rank test of flow mediated dilation (FMD) between all subjects (POTS & control subjects) on the high sodium diet vs low sodium diet (NCT01550315)
Timeframe: FMD was assessed on the morning of day 7, after 6 days of being on either a high salt diet or a low salt diet.

Interventionpercentage of change (Mean)
High Sodium POTS12.75
Low Sodium Diet POTS11.65
High Sodium Controls11.43
Low Sodium Controls12.75

Reviews

1 review available for nitroglycerin and Obesity

ArticleYear
Angina pectoris: diagnosis, evaluation and therapy.
    Geriatrics, 1973, Volume: 28, Issue:11

    Topics: Angina Pectoris; Angiography; Digitalis Glycosides; Ethanol; Female; Heart Function Tests; Humans; M

1973

Trials

5 trials available for nitroglycerin and Obesity

ArticleYear
Adiponectin relates to smooth muscle function and folate in obese children.
    International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2010, Volume: 5, Issue:2

    Topics: Adiponectin; Adolescent; Body Mass Index; Child; Cholesterol, LDL; Cross-Sectional Studies; Endothel

2010
Apolipoprotein B-48 as a determinant of endothelial function in obese subjects with type 2 diabetes mellitus: effect of fenofibrate treatment.
    Atherosclerosis, 2012, Volume: 221, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Apolipoprotein B-48; Apolipoprotein C-III; Brachial Artery; Chole

2012
Hypoadiponectinemia is closely linked to endothelial dysfunction in man.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:7

    Topics: Adiponectin; Adult; Body Mass Index; Endothelium, Vascular; Fasting; Forearm; Humans; Intercellular

2003
Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise.
    The Journal of pediatrics, 2004, Volume: 145, Issue:6

    Topics: Adolescent; Blood Glucose; Body Mass Index; C-Reactive Protein; Child; Cholesterol; Endothelium, Vas

2004
Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:2

    Topics: Adult; Blood Pressure; Brachial Artery; Diet, Carbohydrate-Restricted; Diet, Fat-Restricted; Endothe

2008

Other Studies

29 other studies available for nitroglycerin and Obesity

ArticleYear
Effect of menopause and age on vascular impairment.
    Maturitas, 2023, Volume: 169

    Topics: Brachial Artery; Cardiovascular Diseases; Endothelium, Vascular; Female; Humans; Hypoxia; Menopause;

2023
[Оptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity].
    Georgian medical news, 2013, Issue:224

    Topics: Adult; Aged; Angina, Stable; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Body Weight;

2013
Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:19

    Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cal

2015
Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects.
    Atherosclerosis, 2009, Volume: 204, Issue:2

    Topics: Adenosine Diphosphate; Adult; Albuterol; Arginine; Body Composition; C-Reactive Protein; Cohort Stud

2009
The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:4

    Topics: Adaptation, Physiological; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Atherosclerosis;

2009
Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats.
    AAPS pharmSci, 2002, Volume: 4, Issue:4

    Topics: Analysis of Variance; Animals; Male; Models, Animal; Nitroglycerin; Obesity; Rats; Rats, Sprague-Daw

2002
Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome.
    Diabetes care, 2003, Volume: 26, Issue:7

    Topics: Blood Flow Velocity; Blood Pressure; Body Mass Index; Brachial Artery; Endothelium, Vascular; Exerci

2003
Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.
    Thrombosis research, 2003, Apr-15, Volume: 110, Issue:1

    Topics: Acetylcysteine; Adenosine Diphosphate; Adult; Amifostine; Antioxidants; Collagen; Cyclic GMP; Drug R

2003
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
    Journal of the American Geriatrics Society, 1964, Volume: 12

    Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates;

1964
Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats.
    Life sciences, 2003, Nov-14, Volume: 73, Issue:26

    Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Blotting, Western; Cerebrovascular Circul

2003
Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients.
    The American journal of cardiology, 2005, Jan-15, Volume: 95, Issue:2

    Topics: Adult; Blood Glucose; Brachial Artery; Endothelium, Vascular; Female; Gastric Bypass; Humans; Male;

2005
Keeping track of the patch: transdermal delivery in obese patients.
    The American journal of nursing, 2005, Volume: 105, Issue:6

    Topics: Administration, Cutaneous; Angina Pectoris; Diabetes Mellitus, Type 2; Female; Humans; Middle Aged;

2005
Endothelial microparticles correlate with endothelial dysfunction in obese women.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:9

    Topics: Adult; Body Mass Index; Brachial Artery; Endothelial Cells; Endothelium; Female; Humans; Middle Aged

2006
Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:11

    Topics: Aged; Arterioles; Body Mass Index; Brachial Artery; Bradykinin; Coronary Vessels; Female; Humans; Hy

2007
Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure.
    European heart journal, 2008, Volume: 29, Issue:6

    Topics: Atherosclerosis; Blood Pressure; Brachial Artery; Carotid Artery Diseases; Carotid Artery, Common; C

2008
Decreased potency of contraction to alpha-adrenoceptor stimulation in renal arteries from obese hypertensive dogs.
    The American journal of physiology, 1993, Volume: 265, Issue:4 Pt 2

    Topics: Animals; Dinoprost; Dogs; Endothelins; Female; Hypertension; In Vitro Techniques; Nitroglycerin; Obe

1993
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.
    Diabetes care, 1998, Volume: 21, Issue:1

    Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Blood Glucose; Blood Platelets; Blood Pressure;

1998
The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:5

    Topics: Adipose Tissue; Adult; Blood Flow Velocity; Body Constitution; Body Mass Index; Brachial Artery; Cho

1998
[Combined nitroglycerin-heparin infusion in mesenteric venous thrombosis].
    Ugeskrift for laeger, 1998, Jun-08, Volume: 160, Issue:24

    Topics: Adult; Anticoagulants; Drug Combinations; Female; Heparin; Humans; Infusions, Intravenous; Intestine

1998
The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery.
    Japanese circulation journal, 1998, Volume: 62, Issue:6

    Topics: Adult; Aged; Angina, Unstable; Brachial Artery; Coronary Angiography; Coronary Artery Disease; Coron

1998
Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo.
    British journal of pharmacology, 1998, Volume: 125, Issue:4

    Topics: Acetylcholine; Animals; Antioxidants; Body Weight; Dietary Supplements; Drug Tolerance; Lipid Peroxi

1998
Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1999, Volume: 23, Issue:9

    Topics: Adipose Tissue; Adult; Arteriosclerosis; Biomarkers; Blood Flow Velocity; Body Composition; Endothel

1999
Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries.
    Journal of the American College of Cardiology, 2001, Volume: 37, Issue:6

    Topics: Acetylcholine; Adenosine; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Analysis of

2001
Pseudonormal diastolic filling unmasked with glyceryl trinitrate in patients with type 2 diabetes with poor metabolic control.
    Diabetes care, 2001, Volume: 24, Issue:7

    Topics: Biomarkers; Blood Glucose; Body Surface Area; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diastole

2001
Modern medical management of angina pectoris.
    Cardiovascular clinics, 1975, Volume: 7, Issue:1

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Assisted Circulation; Coronary Angiography; Digitalis

1975
[Rheoencephalographic method of of analyzing several risk factors for cerebrovascular disease (epidemiologic study)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:1

    Topics: Adult; Age Factors; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Hypercho

1977
[Possibilities in the prevention of myocardial infarct].
    Medizinische Monatsschrift, 1974, Volume: 28, Issue:6

    Topics: Adrenergic beta-Antagonists; Age Factors; Gymnastics; Humans; Hypertension; Myocardial Infarction; N

1974
Medical management of angina pectoris.
    Circulation, 1972, Volume: 46, Issue:6

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Anticoagulants; Antidepressive Agents; Blood Pressure;

1972
The medical and surgical treatment of angina pectoris.
    Physiotherapy, 1972, Volume: 58, Issue:10

    Topics: Angina Pectoris; Epinephrine; Exercise Therapy; Humans; Nitroglycerin; Norepinephrine; Obesity; Smok

1972