nitroglycerin and Myocardial Ischemia studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Research Excerpts

Excerpt	Relevance	Reference
"To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia."	9.30	Effects of Nicorandil Versus Nitroglycerin on Arterial Oxygenation During Two-Lung Ventilation and One-Lung Ventilation in Patients With Risk Factors for Myocardial Ischemia: A Prospective, Randomized, Double-Blind Study. ( Inoue, M; Kawano, H; Kinoshita, M; Kondo, A; Murakami, C, 2019)
"Intermittent intravenous dobutamine therapy is used to treat patients with decompensated end-stage chronic heart failure (CHF), in whom the vascular endothelium is usually impaired."	9.11	Impact of short-term intermittent intravenous dobutamine therapy on endothelial function in patients with severe chronic heart failure. ( Feinberg, MS; Freimark, D; Hochberg, N; Matezky, S; Shechter, M, 2004)
"To investigate the effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease (CAD)."	9.11	The effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease. ( Bedding, A; Braat, S; Effron, M; Emmick, J; Kloner, R; MacDonald, T; Mitchell, M; Patterson, D; Warner, M, 2005)
" The aim of the present study was to compare the efficacy of nitroglycerin transdermal patches intermittently or continuously administered to patients with myocardial ischemia evaluated by the echocardiography dipyridamole stress test."	9.10	Efficacy of transdermal nitroglycerin patches evaluated by dipyridamole-induced myocardial ischemia in patients with coronary artery disease. Comparison between continuous and intermittent schedule. ( Abete, P; Ferrara, N; Furgi, G; Leosco, D; Longobardi, G; Nicolino, A; Rengo, F; Vitale, DF, 2002)
"To evaluate the use of a high dose of nitroglycerin (NTG) for prophylaxis against myocardial ischemia and infarction in patients undergoing coronary artery bypass graft (CABG) surgery with accelerated recovery."	9.09	Prophylactic nitroglycerin did not reduce myocardial ischemia during accelerated recovery management of coronary artery bypass graft surgery patients. ( Groban, L; Hammon, JW; Hines, M; Kon, ND; Murphy, B; Prielipp, RC; Rogers, AT; Royster, RL; Zvara, DA, 2000)
"This study was aimed at assessing the incidence and mechanisms of myocardial ischemia early after coronary artery bypass grafting and the effects of treatment with nitroglycerine."	9.08	Early postoperative myocardial ischemia after coronary artery bypass grafting. Detrimental effects of nitroglycerine infusion. ( Chiariello, L; Cirillo, F; Crea, F; De Paulis, R; Gaspardone, A; Gioffrè, PA; Iamele, M; Penta de Peppo, A; Pierri, MD; Tomai, F, 1995)
" In order to test the immediate response of right ventricular hemodynamic parameters to nitroglycerin and dobutamine usually used to treat severe left ventricular dysfunction, we studied 17 congestive heart failure patients (15 men, two women; mean age 55 +/- 13 years) with end-stage idiopathic dilated cardiomyopathy (n = 10) or end-stage ischemic heart disease (n = 7), left ventricular ejection fraction < 35% (mean 22 +/- 8%), and sinus rhythm."	9.08	Beneficial cumulative role of both nitroglycerin and dobutamine on right ventricular systolic function in congestive heart failure patients awaiting heart transplantation. ( Berder, V; Cherrier, F; Danchin, N; Feldmann, L; Juillière, Y; Perrin, O, 1995)
"The antianginal efficacy of 240 mg sustained release verapamil once daily doses and 300 mg diltiazem was studied in 20 normotensive patients with chronic stable angina pectoris, using a randomized, double-blind crossover design."	9.08	Antianginal efficacy over 24 hours and exercise hemodynamic effects of once daily sustained-release 300 mg diltiazem and 240 mg verapamil in stable angina pectoris. ( Ciaburri, F; De Rosa, ML; Della Guardia, D; Giordano, A; Melfi, M; Rengo, F, 1998)
"The efficacy and safety of amlodipine (5-10 mg) once daily were studied in an open study in patients with symptomatic myocardial ischemia."	9.07	An open multicenter efficacy and safety evaluation of amlodipine in the treatment of symptomatic myocardial ischemia. ( Beckerman, B, 1991)
"This study was carried out to determine the effect of the once-daily calcium channel blocking agent amlodipine (half-life 35 to 50 h) on the circadian pattern of myocardial ischemia in patients with chronic stable angina."	9.07	Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind Circadian Anti-Ischemia Program in Europe (CAPE Trial). ( Deanfield, JE; Detry, JM; Lichtlen, PR; Magnani, B; Sellier, P; Thaulow, E, 1994)
"Short-term, intermittent nitroglycerin patch therapy significantly reduces myocardial ischemia, particularly in patients with large ischemic perfusion defects."	9.07	Transdermal nitroglycerin patch therapy reduces the extent of exercise-induced myocardial ischemia: results of a double-blind, placebo-controlled trial using quantitative thallium-201 tomography. ( Fenimore, NL; Francis, MJ; Mahmarian, JJ; Marks, GF; Morales-Ballejo, H; Pratt, CM; Verani, MS, 1994)
"The optimal medical regimen for the treatment of cocaine associated myocardial ischemia has not been defined."	9.07	Nitroglycerin in the treatment of cocaine associated chest pain--clinical safety and efficacy. ( DiSano, MJ; Dyer, S; Fairweather, P; Feldman, JA; Fish, SS; Gennis, P; Hoffman, RS; Hollander, JE; Schumb, DA; Wax, P, 1994)
"A prospective, randomized study was performed on 120 patients undergoing elective coronary bypass grafting to define the effect of the calcium channel blocker diltiazem on perioperative ischemia, arrhythmias, and myocardial function."	9.07	Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting. ( Christoph, M; Fasol, R; Gleichauf, M; Hannes, W; Keilich, M; Seitelberger, R, 1994)
"The aim of our study was to investigate the effect of transdermal nitroglycerin (NTG) on effort-induced silent myocardial ischemia in asymptomatic patients treated with beta-blockers or calcium antagonists."	9.07	Efficacy of long-term administration of transdermal nitroglycerin in asymptomatic patients with effort-induced silent myocardial ischemia. ( Bracchetti, D; Casella, G; Mezzetti, M; Pavesi, PC; Rubboli, A; Sangiorgio, P, 1994)
"To evaluate the efficacy of intravenous nitroglycerin (TNG) in preventing intraoperative myocardial ischemia (MI) under general anesthesia."	8.95	Efficacy of prophylactic doses of intravenous nitroglycerin in preventing myocardial ischemia under general anesthesia: A systematic review and meta-analysis with trial sequential analysis. ( Denawa, Y; Hoshijima, H; Iwase, Y; Kuratani, N; Mieda, T; Mihara, T; Nagasaka, H; Shiga, T; Takeuchi, R; Wajima, Z, 2017)
"The responses of cardiovascular parameters to left-ventricular myocardial ischemia induced under control conditions and after administration of nitroglycerin or acetylcholine were examined in rabbits."	7.80	Changes in pulmonary hemodynamics induced by experimental myocardial ischemia in nitroglycerin- or acetylcholine-treated rabbits. ( Evlakhov, VI; Poyasov, IZ, 2014)
"Nitroglycerin only has a limited late preconditioning protective effect in conscious animals submitted to a reversible prolonged ischemia since it protects against arrhythmias but not against stunning."	7.74	Nitroglycerin induces late preconditioning against arrhythmias but not stunning in conscious sheep. ( Lascano, EC; Negroni, JA; Valle, HF, 2007)
"In women with suspected myocardial ischemia, higher genistein blood levels are associated with impaired nonendothelial-dependent and endothelial-dependent coronary microvascular function."	7.74	Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) Study. ( Bairey Merz, CN; Johnson, BD; Kelsey, SF; Kerensky, RA; McGorray, SP; Pepine, CJ; Pohost, G; Reis, SE; Rogers, WJ; Sopko, G; von Mering, GO, 2007)
"ST-segment elevation is frequently induced by dobutamine in patients with a recent myocardial infarction and may represent dyskinesia of the infarcted region or myocardial viability and ischaemia."	7.72	Dobutamine-induced ST-segment elevation associated with a biphasic response of wall motion in patients with a recent myocardial infarction is caused by myocardial ischaemia and is abolished by revascularization of the infarct-related artery. ( Canosi, U; Klersy, C; Lanzarini, L; Previtali, M; Scelsi, L; Sebastiani, R, 2003)
"This study was undertaken to evaluate the efficacy of an early 201Tl reinjection and imaging protocol in combination with sublingual nitroglycerin, to detect myocardial ischemia and/or viability, and to reduce the need for conventional (4 h) redistribution imaging."	7.70	Early postexercise thallium-201 reinjection after sublingual nitroglycerin augmentation: effects on detection of myocardial ischemia and/or viability. ( Antonopoulos, A; Georgiou, E; Kyriakidis, M; Nikolopoulos, D; Proukakis, C; Toutouzas, P, 1998)
"ST-elevation acute myocardial ischemia occurred after phenylephrine infusion in a patient with severe coronary artery disease and recent myocardial infarction."	7.70	Autonomic neural control during acute myocardial ischemia after phenylephrine infusion and subsequent nitroglycerin-induced hypotension and bradycardia. ( Del Greco, M; Disertori, M; Nollo, G, 1999)
"An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead."	7.69	Myocardial ischemia induced by topical use of 5-fluorouracil. ( Gotsman, MS; Gurewich, J; Rozenman, Y, 1995)
"Nitroglycerin-induced hypoxia does not compromise oxidative metabolism of myocardium as can be assessed by a concomitant decrease in coronary sinus lactate concentration."	7.69	Nitroglycerin-induced hypoxemia does not produce myocardial ischemia. ( Bilgen, F; Calişirişçi, U; Canik, S; Demirtaş, M; Kopman, EA; Ozler, A; Toraman, F; Yiğiter, B, 1997)
"The nitroglycerin-induced increase in tissue Po2 was disproportionate to the increase in MBF, indicating enhanced O2 unloading."	5.33	Effects of nitroglycerin on erythrocyte rheology and oxygen unloading: novel role of S-nitrosohemoglobin in relieving myocardial ischemia. ( Bin, JP; Christiansen, J; Doctor, A; Fisher, NG; Hendersen, EM; Kaul, S; Le, DE; Leong-Poi, H; Lindner, J, 2006)
"Nitroglycerine was infused under pressure into the internal thoracic artery in experimental group."	5.32	[Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia]. ( Sheng, J; Wang, CF; Wu, X; Zhu, J, 2004)
"To compare the effects of nicorandil and nitroglycerin on arterial oxygenation during two-lung ventilation (TLV) and one-lung ventilation (OLV) in patients with risk factors for myocardial ischemia."	5.30	Effects of Nicorandil Versus Nitroglycerin on Arterial Oxygenation During Two-Lung Ventilation and One-Lung Ventilation in Patients With Risk Factors for Myocardial Ischemia: A Prospective, Randomized, Double-Blind Study. ( Inoue, M; Kawano, H; Kinoshita, M; Kondo, A; Murakami, C, 2019)
"5-Fluorouracil (5-FU) is a commonly employed chemotherapeutic agent."	5.29	In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. ( Chokshi, S; Fingert, HJ; Isner, JM; Mosseri, M; Varticovski, L, 1993)
"Nitroglycerin was given by intravenous infusion for 5-7 days."	5.28	[The effects of nitroglycerin on refractory congestive heart failure by intravenous infusion]. ( Ma, S, 1992)
"To determine whether, at trough levels, ranolazine improves the total exercise time of patients who have symptoms of chronic angina and who experience angina and ischemia at low workloads despite taking standard doses of atenolol, amlodipine, or diltiazem and to determine times to angina onset and to electrocardiographic evidence of myocardial ischemia, effect on angina attacks and nitroglycerin use, and effect on long-term survival in an open-label observational study extension."	5.11	Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. ( Chaitman, BR; Chumakova, G; Kuch, J; Parker, JO; Pepine, CJ; Skettino, SL; Skopal, J; Wang, W; Wolff, AA, 2004)
"Intermittent intravenous dobutamine therapy is used to treat patients with decompensated end-stage chronic heart failure (CHF), in whom the vascular endothelium is usually impaired."	5.11	Impact of short-term intermittent intravenous dobutamine therapy on endothelial function in patients with severe chronic heart failure. ( Feinberg, MS; Freimark, D; Hochberg, N; Matezky, S; Shechter, M, 2004)
"To investigate the effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease (CAD)."	5.11	The effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease. ( Bedding, A; Braat, S; Effron, M; Emmick, J; Kloner, R; MacDonald, T; Mitchell, M; Patterson, D; Warner, M, 2005)
" The aim of the present study was to compare the efficacy of nitroglycerin transdermal patches intermittently or continuously administered to patients with myocardial ischemia evaluated by the echocardiography dipyridamole stress test."	5.10	Efficacy of transdermal nitroglycerin patches evaluated by dipyridamole-induced myocardial ischemia in patients with coronary artery disease. Comparison between continuous and intermittent schedule. ( Abete, P; Ferrara, N; Furgi, G; Leosco, D; Longobardi, G; Nicolino, A; Rengo, F; Vitale, DF, 2002)
"The aim of this study was to assess the influence of incremental nitroglycerin infusion (NTG+Inf) on the myocardial uptake of 99mTc-tetrofosmin (TF) in order to determine whether nitrates enhance the detection of viable myocardium with TF in patients with coronary artery disease (CAD) and left ventricular dysfunction."	5.10	Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium-201. ( Ergin, A; Kula, M; Topsakal, R; Tutuş, A; Unal, S, 2003)
"A randomized single blind cross-over trial with placebo lead-in has been conducted in 71 anginal patients with arterial hypotension (group 1) and 38 ischemic heart disease patients with normal arterial pressure (group 2) to compare efficacy of therapy with isosorbide dinitrate (ID), sustac-forte (SF), isosorbide dinitrate retard (IDR) and trinitrolong (TN)."	5.10	[Nitrates in therapy of effort angina in hypotensive patients]. ( Borovkova, NV; Chernov, VI; Demochko, AV; Idrisova, EM; Karpov, RS; Kladieva, EA; Shishkina, AA; Vorob'eva, EV, 2003)
"We assessed the efficacy of a continuous infusion of nicardipine and nitroglycerin in reducing the incidence and severity of perioperative myocardial ischemia during elective coronary artery bypass grafting procedures in a prospective, randomized, controlled study."	5.09	Antiischemic effects of nicardipine and nitroglycerin after coronary artery bypass grafting. ( Apostolidou, IA; Despotis, GJ; Hauptmann, EL; Hogue, CW; Lappas, DG; McCawley, CA; Skubas, NJ, 1999)
"To evaluate the use of a high dose of nitroglycerin (NTG) for prophylaxis against myocardial ischemia and infarction in patients undergoing coronary artery bypass graft (CABG) surgery with accelerated recovery."	5.09	Prophylactic nitroglycerin did not reduce myocardial ischemia during accelerated recovery management of coronary artery bypass graft surgery patients. ( Groban, L; Hammon, JW; Hines, M; Kon, ND; Murphy, B; Prielipp, RC; Rogers, AT; Royster, RL; Zvara, DA, 2000)
"We evaluated the clinical efficacy of transdermal nitroglycerin (NTG-TTS), a patch application of a nitrate, in the treatment of 27 patients with angina pectoris who had asymptomatic myocardial ischemic (SMI) attacks, using a double-blind cross-over method."	5.09	Efficacy of anti-anginal drugs in the treatment of angina pectoris associated with silent myocardial ischemia: importance of quantitative Holter ECG data for patient activity. ( Ino-Oka, E; Inooka, H; Kutsuwa, Y; Sagawa, K; Takahashi, T; Umeda, S, 2000)
"Perioperative infusion of the calcium channel antagonist diltiazem reduces the occurrence and extent of postoperative myocardial ischemia."	5.09	Diltiazem versus nitroglycerin for myocardial protection following coronary artery bypass grafting as assessed by dobutamine stress echocardiography. ( Chevtchik, O; Grubhofer, G; Hiesmayr, M; Lassnigg, A; Podesser, B; Seitelberger, R; Simon-Kupilik, N; Wild, T; Wutte, M, 2001)
"This study was conducted to determine whether rebound ischemia occurs during nitrate-free periods with intermittent cutaneous nitroglycerin therapy in patients with angina pectoris who are receiving background antianginal therapy."	5.08	Intermittent transdermal nitrates do not improve ischemia in patients taking beta-blockers or calcium antagonists: potential role of rebound ischemia during the nitrate-free period. ( Daxini, BV; Freedman, SB; Kelly, DT; Noyce, D, 1995)
"This study was aimed at assessing the incidence and mechanisms of myocardial ischemia early after coronary artery bypass grafting and the effects of treatment with nitroglycerine."	5.08	Early postoperative myocardial ischemia after coronary artery bypass grafting. Detrimental effects of nitroglycerine infusion. ( Chiariello, L; Cirillo, F; Crea, F; De Paulis, R; Gaspardone, A; Gioffrè, PA; Iamele, M; Penta de Peppo, A; Pierri, MD; Tomai, F, 1995)
" In order to test the immediate response of right ventricular hemodynamic parameters to nitroglycerin and dobutamine usually used to treat severe left ventricular dysfunction, we studied 17 congestive heart failure patients (15 men, two women; mean age 55 +/- 13 years) with end-stage idiopathic dilated cardiomyopathy (n = 10) or end-stage ischemic heart disease (n = 7), left ventricular ejection fraction < 35% (mean 22 +/- 8%), and sinus rhythm."	5.08	Beneficial cumulative role of both nitroglycerin and dobutamine on right ventricular systolic function in congestive heart failure patients awaiting heart transplantation. ( Berder, V; Cherrier, F; Danchin, N; Feldmann, L; Juillière, Y; Perrin, O, 1995)
" Two patients in group 2 required treatment with nitroglycerin for myocardial ischemia."	5.08	The effect of midazolam at two plasma concentrations of hemodynamics and sufentanil requirement in coronary artery surgery. ( Epema, AH; Hennis, PJ; Huet, RC; van der Maaten, JM, 1996)
"We sought to evaluate the effects of intermittent transdermal nitroglycerin (TD-NTG) on the occurrence of ischemia during patch-off hours in patients with stable angina pectoris receiving a beta-adrenergic blocking agent or calcium antagonist, or both."	5.08	Effects of intermittent transdermal nitroglycerin on occurrence of ischemia after patch removal: results of the second transdermal intermittent dosing evaluation study (TIDES-II). ( Bell, DM; Handberg-Thurmond, EM; Lopez, LM; Marks, RG; McGorray, S; Pepine, CJ, 1997)
"The present study demonstrates that diltiazem infusion provides superior anti-ischemic protection and control of supraventricular arrhythmias as compared to nitroglycerin and does not produce any negative inotropic effect, as demonstrated by transesophageal echocardiography."	5.08	Cardioprotective effects of diltiazem infusion in the perioperative period. ( Kler, TS; Kohli, VM; Malhotra, R; Mehta, Y; Mishra, M; Trehan, N, 1997)
"Three hundred nine patients with coronary artery disease, stable angina pectoris, and positive exercise tests were randomized to receive mibefradil (50, 100, or 150 mg), amlodipine (10 mg), or placebo."	5.08	Efficacy of mibefradil compared with amlodipine in suppressing exercise-induced and daily silent ischemia: results of a multicenter, placebo-controlled trial. ( Braat, S; Kadr, H; Kobrin, I; Ramires, JA; Rutsch, W; Tzivoni, D, 1997)
"The antianginal efficacy of 240 mg sustained release verapamil once daily doses and 300 mg diltiazem was studied in 20 normotensive patients with chronic stable angina pectoris, using a randomized, double-blind crossover design."	5.08	Antianginal efficacy over 24 hours and exercise hemodynamic effects of once daily sustained-release 300 mg diltiazem and 240 mg verapamil in stable angina pectoris. ( Ciaburri, F; De Rosa, ML; Della Guardia, D; Giordano, A; Melfi, M; Rengo, F, 1998)
"The efficacy and safety of amlodipine (5-10 mg) once daily were studied in an open study in patients with symptomatic myocardial ischemia."	5.07	An open multicenter efficacy and safety evaluation of amlodipine in the treatment of symptomatic myocardial ischemia. ( Beckerman, B, 1991)
"This study was carried out to determine the effect of the once-daily calcium channel blocking agent amlodipine (half-life 35 to 50 h) on the circadian pattern of myocardial ischemia in patients with chronic stable angina."	5.07	Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind Circadian Anti-Ischemia Program in Europe (CAPE Trial). ( Deanfield, JE; Detry, JM; Lichtlen, PR; Magnani, B; Sellier, P; Thaulow, E, 1994)
"Short-term, intermittent nitroglycerin patch therapy significantly reduces myocardial ischemia, particularly in patients with large ischemic perfusion defects."	5.07	Transdermal nitroglycerin patch therapy reduces the extent of exercise-induced myocardial ischemia: results of a double-blind, placebo-controlled trial using quantitative thallium-201 tomography. ( Fenimore, NL; Francis, MJ; Mahmarian, JJ; Marks, GF; Morales-Ballejo, H; Pratt, CM; Verani, MS, 1994)
"The optimal medical regimen for the treatment of cocaine associated myocardial ischemia has not been defined."	5.07	Nitroglycerin in the treatment of cocaine associated chest pain--clinical safety and efficacy. ( DiSano, MJ; Dyer, S; Fairweather, P; Feldman, JA; Fish, SS; Gennis, P; Hoffman, RS; Hollander, JE; Schumb, DA; Wax, P, 1994)
"A prospective, randomized study was performed on 120 patients undergoing elective coronary bypass grafting to define the effect of the calcium channel blocker diltiazem on perioperative ischemia, arrhythmias, and myocardial function."	5.07	Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting. ( Christoph, M; Fasol, R; Gleichauf, M; Hannes, W; Keilich, M; Seitelberger, R, 1994)
"The aim of our study was to investigate the effect of transdermal nitroglycerin (NTG) on effort-induced silent myocardial ischemia in asymptomatic patients treated with beta-blockers or calcium antagonists."	5.07	Efficacy of long-term administration of transdermal nitroglycerin in asymptomatic patients with effort-induced silent myocardial ischemia. ( Bracchetti, D; Casella, G; Mezzetti, M; Pavesi, PC; Rubboli, A; Sangiorgio, P, 1994)
"The results indicate that when used as monotherapy, intermittent transdermal nitroglycerin preparations lessen symptoms but are ineffective for the long-term prophylaxis of silent myocardial ischemia."	5.07	Transdermal nitroglycerin reduces the frequency of anginal attacks but fails to prevent silent ischemia. ( Bonetti, F; Chierchia, SL; Luca, C; Rossetti, E, 1993)
"We evaluated the impact of prophylactic nitroglycerin on the incidence of perioperative myocardial ischemia in patients with known or suspected coronary artery disease who undergo noncardiac surgery."	5.07	Prophylactic nitroglycerin infusion during noncardiac surgery does not reduce perioperative ischemia. ( Coromilas, J; Dodds, TM; Levy, DG; Stone, JG; Weinberger, M, 1993)
"To evaluate the efficacy of intravenous nitroglycerin (TNG) in preventing intraoperative myocardial ischemia (MI) under general anesthesia."	4.95	Efficacy of prophylactic doses of intravenous nitroglycerin in preventing myocardial ischemia under general anesthesia: A systematic review and meta-analysis with trial sequential analysis. ( Denawa, Y; Hoshijima, H; Iwase, Y; Kuratani, N; Mieda, T; Mihara, T; Nagasaka, H; Shiga, T; Takeuchi, R; Wajima, Z, 2017)
"Short-acting nitrates are beneficial in acute myocardial ischemia."	4.91	Use of nitrates in ischemic heart disease. ( Giuseppe, C; Hans-Ulrich, I; Paul, J, 2015)
"We report a 23-month old girl who presented with bilateral epiphora who underwent bilateral lacrimal probing and syringing, during which a cocaine adrenaline solution was used."	3.81	Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure. ( McGovern, E; McMahon, CJ; Moylett, E, 2015)
" We investigated the ameliorating effect of CGRP in myocardial ischemia induced by endothelin-1 (ET-1), with special emphasis on myocardial microvascular hemodynamics and levels of energy-related metabolites."	3.80	Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1: intravital microscopic observation and (31)P-MR spectroscopic studies. ( Aonuma, K; Homma, S; Kimura, T; Miyauchi, T; Miyauchi, Y; Sakai, S; Yanagi, K, 2014)
"The responses of cardiovascular parameters to left-ventricular myocardial ischemia induced under control conditions and after administration of nitroglycerin or acetylcholine were examined in rabbits."	3.80	Changes in pulmonary hemodynamics induced by experimental myocardial ischemia in nitroglycerin- or acetylcholine-treated rabbits. ( Evlakhov, VI; Poyasov, IZ, 2014)
"In 30 patients with chest pain and angiographically normal coronary arteries or mild atherosclerosis, we studied endothelium-dependent responses with acetylcholine (ACH) and endothelium-independent function with nitroglycerin and adenosine in the left anterior descending artery."	3.77	Myocardial ischaemia in patients with coronary endothelial dysfunction: insights from body surface ECG mapping and implications for invasive evaluation of chronic chest pain. ( Lennon, RJ; Lerman, A; Prasad, A; Rihal, CS; Summers, MR, 2011)
" Continuous infusion of nitroglycerin was started during CPB and continued after CPB to dilate the newly implanted coronary arteries for the prevention of myocardial ischemia and to decrease afterload and pulmonary vascular resistance."	3.75	Anesthetic management for severe aortic regurgitation in an infant repaired by Ross procedure. ( Harasawa, K; Morimoto, Y; Saito, H; Watabe, A, 2009)
"Nitroglycerin only has a limited late preconditioning protective effect in conscious animals submitted to a reversible prolonged ischemia since it protects against arrhythmias but not against stunning."	3.74	Nitroglycerin induces late preconditioning against arrhythmias but not stunning in conscious sheep. ( Lascano, EC; Negroni, JA; Valle, HF, 2007)
"In women with suspected myocardial ischemia, higher genistein blood levels are associated with impaired nonendothelial-dependent and endothelial-dependent coronary microvascular function."	3.74	Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) Study. ( Bairey Merz, CN; Johnson, BD; Kelsey, SF; Kerensky, RA; McGorray, SP; Pepine, CJ; Pohost, G; Reis, SE; Rogers, WJ; Sopko, G; von Mering, GO, 2007)
"We investigated the antiarrhythmic effects of intrapericardial nitroglycerin (NTG) during acute myocardial ischemia in the porcine heart."	3.72	Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart. ( Kumar, K; Nearing, BD; Nguyen, K; Verrier, RL; Waxman, S; Wellenius, GA; Zhao, SX, 2003)
"ST-segment elevation is frequently induced by dobutamine in patients with a recent myocardial infarction and may represent dyskinesia of the infarcted region or myocardial viability and ischaemia."	3.72	Dobutamine-induced ST-segment elevation associated with a biphasic response of wall motion in patients with a recent myocardial infarction is caused by myocardial ischaemia and is abolished by revascularization of the infarct-related artery. ( Canosi, U; Klersy, C; Lanzarini, L; Previtali, M; Scelsi, L; Sebastiani, R, 2003)
"As part of the Women's Ischemia Syndrome Evaluation (WISE) sponsored by the National Heart, Lung, and Blood Institute, 163 women referred for clinically indicated coronary angiography underwent coronary reactivity assessment with quantitative coronary angiography and intracoronary Doppler flow before and after intracoronary administration of acetylcholine, adenosine, and nitroglycerin and were then followed up for clinical outcomes."	3.72	Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). ( Arant, CB; Bairey Merz, CN; Handberg, E; Johnson, BD; Kerensky, RA; McGorray, SP; Olson, MB; Pepine, CJ; Sharaf, BL; Smith, KM; Sopko, G; von Mering, GO; Wessel, TR, 2004)
"This study was undertaken to evaluate the efficacy of an early 201Tl reinjection and imaging protocol in combination with sublingual nitroglycerin, to detect myocardial ischemia and/or viability, and to reduce the need for conventional (4 h) redistribution imaging."	3.70	Early postexercise thallium-201 reinjection after sublingual nitroglycerin augmentation: effects on detection of myocardial ischemia and/or viability. ( Antonopoulos, A; Georgiou, E; Kyriakidis, M; Nikolopoulos, D; Proukakis, C; Toutouzas, P, 1998)
"During the management of acute myocardial infarction, we observed that clinical and electrocardiographic indications of myocardial ischemia worsened upon nitroglycerin infusion and were promptly relieved upon streptokinase infusion."	3.70	Is nitroglycerin detrimental in patients with coronary artery ectasia? A case report. ( Caccavo, N; Sanyal, S, 1998)
"ST-elevation acute myocardial ischemia occurred after phenylephrine infusion in a patient with severe coronary artery disease and recent myocardial infarction."	3.70	Autonomic neural control during acute myocardial ischemia after phenylephrine infusion and subsequent nitroglycerin-induced hypotension and bradycardia. ( Del Greco, M; Disertori, M; Nollo, G, 1999)
"An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead."	3.69	Myocardial ischemia induced by topical use of 5-fluorouracil. ( Gotsman, MS; Gurewich, J; Rozenman, Y, 1995)
" The administration of nitroglycerin during cardiac PET imaging results in improved resting defects, which suggests transiently abnormal resting perfusion with silent myocardial ischemia."	3.69	Silent myocardial ischemia during PET. ( Garza, D; Grella, R; Horowitz, SF; Nagy, B; Van Tosh, A, 1995)
"Rapid atrial pacing was used to induce myocardial ischemia, with the same pacing rate before and after an intracoronary injection of 50 micrograms nitroglycerin."	3.69	Variable responses of highly stenotic coronary arteries and collateral circulation to intracoronary injection of nitroglycerin in patients with chronic effort angina. ( Fujita, M; Inoko, M; Miwa, K; Yamanishi, K, 1994)
"Three hundred prehospital patients who were given nitroglycerin by advanced life support personnel for presumed myocardial ischemia or congestive heart failure; excluded were those without repeat vital signs or ECG monitoring and those given additional medications."	3.69	Safety of prehospital nitroglycerin. ( Holliman, CJ; Meador, S; Roth, GS; Swope, G; Wuerz, R, 1994)
"Local application of low-dose dobutamine together with arterial blood by selective suction and pressure-regulated retroinfusion during brief myocardial ischemia resulted in improved regional myocardial function without undesired effects on non-ischemic myocardium or systemic hemodynamics."	3.69	Targeting of dobutamine to ischemic myocardium without systemic effects by selective suction and pressure-regulated retroinfusion. ( Boekstegers, P; Giehrl, W; von Degenfeld, G, 1997)
"Nitroglycerin-induced hypoxia does not compromise oxidative metabolism of myocardium as can be assessed by a concomitant decrease in coronary sinus lactate concentration."	3.69	Nitroglycerin-induced hypoxemia does not produce myocardial ischemia. ( Bilgen, F; Calişirişçi, U; Canik, S; Demirtaş, M; Kopman, EA; Ozler, A; Toraman, F; Yiğiter, B, 1997)
"In 12 patients undergoing coronary angiography, systolic blood pressure (intraarterial catheter) was reduced by an intravenous bolus of nitroglycerin during a spontaneous episode of transient chest pain and myocardial ischemia (ST segment depression on the electrocardiogram) and 30 min after recovery."	3.68	Impairment of the arterial baroreflex during symptomatic and silent myocardial ischemia in humans. ( Alessio, P; Gregorini, L; Mancia, G; Omboni, S; Perondi, R; Pomidossi, G; Rimini, A; Saino, A; Zanchetti, A, 1993)
"Ranolazine was administered at a dose of 375 mg twice daily for 4 weeks and was increased to 500 mg twice daily for the rest of the study."	2.80	Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease. ( Rehberger-Likozar, A; Šebeštjen, M, 2015)
"It has been reported that the nitrate tolerance related to continuous dosing of nitrates reduces drug efficacy, and therefore eccentric dosing of nitrates is recommended."	2.72	Inhibition of nitrate tolerance without reducing vascular response during eccentric dosing of nitrates. ( Kanamasa, K; Morii, H; Naito, N; Nakano, K, 2006)
"44 patients (pts) with dilated cardiomyopathy (Group I) and 34 patients with ischemic heart disease (Group II) were assessed."	2.72	Markers of pulmonary hypertension in potential candidates to heart transplantation. ( Drwiła, R; Kapelak, B; Konstanty, J; Krochin, M; Marek, G; Piatek, J; Podolec, P; Przybyłowski, P; Rudziński, P; Sadowski, J; Sobczyk, D; Wierzbicki, K; Wójcik, S; Wróbel, K, 2006)
"Nicorandil is an antianginal drug that exerts both a conventional nitrate effect and an independent ATP-dependent potassium channel-opening effect."	2.70	Nicorandil infusion leads to good recovery from ischemia of left ventricular regional work in comparison with nitroglycerin. ( Adachi, H; Hoshizaki, H; Isobe, N; Naito, S; Nogami, A; Oshima, S; Sugawara, M; Taniguchi, K; Toyama, T, 2002)
" To assess whether an unattenuated antiischemic and antianginal efficacy during the hours of intermittent dosing can be maintained, a modified drug-release profile with increasing plasma concentrations was evaluated using a double-blind, placebo-controlled crossover protocol."	2.69	Increasing nitroglycerin release from patches enables circumvention of early nitrate tolerance. ( Lehmann, G; Reiniger, G, 1998)
" We determined the mean of 2 separate measurements of heparin dosage requirement, antithrombin III activity, and the dose of intravenous nitroglycerin or isosorbide dinitrate at the time that the ratio of activated partial thromboplastin time (aPTT) to baseline aPTT was 1."	2.68	Interaction of intravenous heparin and organic nitrates in acute ischemic syndromes. ( Cho, SK; In, HH; Kim, JJ; Kim, SS; Koh, KK; Lee, HJ; Moon, TH; Park, GS; Song, JH, 1995)
"nitroglycerin were studied."	2.67	Clinical response to intravenous nitroglycerin infused through polyethylene or polyvinyl chloride tubing. ( Altavela, JL; Gacioch, GM; Haas, CE; Nowak, DR; Powers, J, 1994)
"Asymmetric dosage regimes have been introduced to circumvent development of nitrate tolerance."	2.67	Influence of glyceryl trinitrate on venous and arterial effects of chronic, asymmetric isosorbide dinitrate treatment in patients with ischemic heart disease. ( Jørgensen, LH; Refsum, HE; Thaulow, E, 1994)
"Both atenolol and diltiazem were of similar efficacy in increasing nonischemic exercise duration in patients with variable-threshold angina and acted primarily by slowing the resting heart rate."	2.67	Investigation of therapeutic mechanisms of atenolol and diltiazem in patients with variable-threshold angina. ( Davies, GJ; Nadazdin, A, 1994)
"Myocardial ischemia was diagnosed by Holter monitoring and the repeated assessment of 12-lead ECG and serum enzyme levels and defined as a transient ischemic event, transient coronary spasm or myocardial infarction."	2.67	Diltiazem provides anti-ischemic and anti-arrhythmic protection in patients undergoing coronary bypass grafting. ( Fasol, R; Hannes, W; Holubarsch, CH; Schindler, M; Schlosser, V; Schumacher, B; Seitelberger, R; Zajonc, H, 1993)
"(i) Cardiac shock wave therapy improves the angina pectoris symptom (including the decrease of Canadian Cardiovascular Society class [-0·86 (-1·12, -0·65), P < 0·00001], nitroglycerin dosage (times/weeks) [-0·71 (-1·08, -0·33), P = 0·0002] and a increase of Seattle Angina Questionnaire score [5·64 (3·12, 8·15), P < 0·0001)]); (ii) CSWT leads to a reduce in heart failure (including a reduction of New York Heart Association functional class [-0·49 (-0·62, -0·37), P < 0·00001], a stable rise in 6-min walking distance [68·38 (39·70, 97·05), P < 0·00001] and a growth in left ventricular ejection fraction with echocardiography screening [6·73 (4·67,8·80), P < 0·00001]); (iii) CSWT improves myocardial viability within improving in total score of perfusion imaging [-5·19 (-8·08, -2·30), P = 0·0004] and total score of metabolism imaging [-5·33 (-7·77, -2·90), P < 0·0001]."	2.52	Clinical effect of cardiac shock wave therapy on patients with ischaemic heart disease: a systematic review and meta-analysis. ( Guo, T; Liu, L; Pan, X; Wang, J; Zhou, C, 2015)
"Hydralazine is an efficient reactive oxygen species (ROS) scavenger and an inhibitor of O2- generation."	2.43	The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine. ( Daiber, A; Hink, U; Mollnau, H; Mülsch, A; Münzel, T; Oelze, M; Warnholtz, A, 2005)
"Consideration of pharmacotherapy of ischemic heart disease in Japan from the aspect of improvement of long-term prognosis shows that calcium antagonists and nitrates, for which there is no evidence of improved long-term mortality, are commonly prescribed, whereas the use of beta-blockers, for which there is clear evidence of improvement, lags well behind Western countries."	2.40	[Evidence-based pharmacological therapy of ischemic heart disease: with reference to the long-term prognosis]. ( Ishikawa, K, 1998)
"The mainstay of treatment of unstable angina (prolonged episode of angina at rest and recent onset angina at rest, or with minimal exertion with a crescendo pattern) is aspirin, heparin, or both."	2.39	Nitrates for unstable angina. ( Opie, LH; Thadani, U, 1994)
"Coronary vasospasm is characterized by transient and reversible vasoconstriction that can cause myocardial ischemia."	1.91	A Rare Case of Vasospasm Presenting with Acute Coronary Syndrome and Leading to Total Occlusion. ( Güzel, T, 2023)
"Participants aged 60 years or more with ischemic heart disease and without a history of hip fracture from The Health Improvement Network, an electronic medical records database in the United Kingdom, were included."	1.46	Intermittent Nitrate Use and Risk of Hip Fracture. ( Kiel, DP; Lu, N; Misra, D; Neogi, T; Peloquin, C; Zhang, Y, 2017)
"Microvascular coronary dysfunction (MCD) in women with no obstructive CAD portends an adverse prognosis of a 2."	1.38	Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. ( Anderson, RD; Azarbal, B; Handberg, E; Johnson, BD; Kar, S; Kelsey, SF; Kothawade, K; Lerman, A; Mehta, PK; Merz, CN; Pepine, CJ; Petersen, J; Samuels, B; Sharaf, B; Shaw, L; Shufelt, C; Sopko, G; Wei, J, 2012)
"nitroglycerin, can increase the radiotracer uptake in areas with moderate and severe hypoperfusion."	1.35	Viable myocardium scintigraphy with intravenous nitroglycerine by computed tomography with Tc-99m (MIBI). ( Almeida, RS; Camargo, TN; Lima, EJ; Nascimento, MW; Ramos Filho, J; Silva, RM, 2008)
"Transient myocardial ischemia was likely due to dobutamine-induced coronary spasm."	1.35	Late myocardial ischemia with ST-segment elevation after negative dobutamine stress echocardiography in a patient with normal coronary arteries. ( Baria, L; Cabani, E; Lattanzi, F; Paci, AM; Pieroni, A; Tommasi, SM, 2009)
"The nitroglycerin-induced increase in tissue Po2 was disproportionate to the increase in MBF, indicating enhanced O2 unloading."	1.33	Effects of nitroglycerin on erythrocyte rheology and oxygen unloading: novel role of S-nitrosohemoglobin in relieving myocardial ischemia. ( Bin, JP; Christiansen, J; Doctor, A; Fisher, NG; Hendersen, EM; Kaul, S; Le, DE; Leong-Poi, H; Lindner, J, 2006)
" The diagnosis of paroxystic ischemic mitral regurgitation was confirmed and a treatment based on high dosage of calcium-blocker was decided."	1.32	[Mitral insufficiency related to a spasm of the left anterior descending artery. A case report]. ( Avierinos, JF; Bonnet, JL; Collart, F; Dieuzaide, P; Franceschi, F; Habib, G; Mesana, T; Quilici, J; Sbragia, P; Thuny, F, 2003)
"Acute mediastinitis is an uncommon and potentially devastating infection."	1.32	Acute mediastinitis: a severe complication of transdermal therapy in a patient with ischaemic heart disease. A case report. ( Cattelan, AM; Concia, E; Faggian, F; Lanzafame, M; Lattuada, E; Trevenzoli, M, 2003)
"Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance."	1.32	Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy. ( Fukudome, T; Hamasaki, S; Ishida, S; Kataoka, T; Minagoe, S; Mizoguchi, E; Ninomiya, Y; Okui, H; Otsuji, Y; Saihara, K; Shinsato, T; Tei, C, 2004)
"Nitroglycerine was infused under pressure into the internal thoracic artery in experimental group."	1.32	[Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia]. ( Sheng, J; Wang, CF; Wu, X; Zhu, J, 2004)
"Esmolol was used in 25% of patients to reduce motion of the left ventricle (LV) during the left internal mammary artery (LIMA)-LAD anastomosis, but was used less often as the surgeons adapted to the use of a retractor that stabilized the ventricular wall adjacent to the site of the LIMA-LAD anastomosis."	1.30	Minimally invasive direct coronary artery bypass: anesthetic, monitoring, and pain control considerations. ( Gravlee, GP; Heres, EK; Magovern, JA; Malkowski, MJ; Marquez, J, 1998)
"When nitroglycerin was used, hemodynamic parameters changed in two stages: 1) systemic blood pressure initially slightly increased; 2) decreases in this and other central hemodynamic parameters occurred."	1.29	[Effects of nitroglycerin on myocardial contraction in patients with ischemic heart disease]. ( Buniamian, AA; Flerov, EV; Iakovlev, VF; Seleznev, MN, 1995)
"5-Fluorouracil (5-FU) is a commonly employed chemotherapeutic agent."	1.29	In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. ( Chokshi, S; Fingert, HJ; Isner, JM; Mosseri, M; Varticovski, L, 1993)
" The beneficial nitrate effect can be preserved by appropriate dosing which provides a period of many hours of nitrate washout during each 24 h period."	1.29	Nitrate tolerance--problems both new and old. ( Parker, JO, 1996)
"Nitroglycerin was given by intravenous infusion for 5-7 days."	1.28	[The effects of nitroglycerin on refractory congestive heart failure by intravenous infusion]. ( Ma, S, 1992)

Research

Studies (198)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Endothelial Dysfunction (FMD)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	112 (56.57)	18.2507
2000's	60 (30.30)	29.6817
2010's	23 (11.62)	24.3611
2020's	3 (1.52)	2.80

Authors	Studies
Güzel, T	1
Takahashi, N	1
Gall, E	1
Fan, D	1
Majid, M	1
Amsterdam, EA	1
Simsek, EC	1
Sari, C	1
Kucukokur, M	1
Ekmekci, C	1
Colak, A	1
Ozdogan, O	1
Hoshijima, H	1
Denawa, Y	1
Mihara, T	1
Takeuchi, R	1
Kuratani, N	1
Mieda, T	1
Iwase, Y	1
Shiga, T	1
Wajima, Z	1
Nagasaka, H	1
Spapen, J	1
Jacobs, R	1
Lochy, S	1
Huyghens, L	1
Spapen, H	1
Murakami, C	1
Kawano, H	1
Kinoshita, M	2
Kondo, A	1
Inoue, M	1
Nawarskas, JJ	1
Koury, J	1
Lauber, DA	1
Felton, LA	1
Hoque, MH	1
Kabir, FI	1
Arzu, J	1
Amin, MR	1
Zaman, SM	1
Ear-E-Mahabub, SM	1
Joarder, AI	1
Singha, CK	1
Banerjee, RS	1
Meyer, N	1
Tran, O	1
Hartsfield, C	1
Nguyen, L	1
Kazi, DS	1
Koch, B	1
Fekete, V	1
Murlasits, Z	1
Aypar, E	1
Bencsik, P	1
Sárközy, M	1
Szénási, G	1
Ferdinandy, P	4
Csont, T	3
Sedlak, TL	1
Johnson, BD	4
Pepine, CJ	6
Reis, SE	2
Bairey Merz, CN	3
Homma, S	1
Kimura, T	1
Sakai, S	2
Yanagi, K	1
Miyauchi, Y	1
Aonuma, K	1
Miyauchi, T	1
Evlakhov, VI	1
Poyasov, IZ	1
Chan, YH	1
Yiu, KH	1
Lau, KK	1
Yiu, YF	1
Li, SW	1
Lam, TH	1
Lau, CP	1
Siu, CW	1
Tse, HF	1
McGovern, E	1
Moylett, E	1
McMahon, CJ	1
Giuseppe, C	1
Paul, J	1
Hans-Ulrich, I	1
Rehberger-Likozar, A	1
Šebeštjen, M	1
Boden, WE	1
Padala, SK	1
Cabral, KP	1
Buschmann, IR	1
Sidhu, MS	1
Wang, J	1
Zhou, C	1
Liu, L	1
Pan, X	1
Guo, T	2
Misra, D	1
Peloquin, C	1
Kiel, DP	1
Neogi, T	1
Lu, N	1
Zhang, Y	1
Tanaka, S	1
Yokoyama, C	1
Kawamura, I	1
Takasugi, N	1
Kubota, T	1
Ushikoshi, H	1
Aoyama, T	1
Kawasaki, M	1
Nishigaki, K	1
Takemura, G	1
Minatoguchi, S	1
Baharvand, B	1
Dehaj, ME	1
Rasoulian, B	1
Namdari, M	1
Shikhani, Y	1
Kiani, AA	1
Zoghbi, GJ	1
Dorfman, TA	1
Iskandrian, AE	1
Ramos Filho, J	1
Nascimento, MW	1
Silva, RM	1
Camargo, TN	1
Almeida, RS	1
Lima, EJ	1
Le Brun-Ly, V	1
Martin, J	1
Venat-Bouvet, L	1
Darodes, N	1
Labourey, JL	1
Genet, D	1
Tubiana-Mathieu, N	1
Cabani, E	1
Lattanzi, F	1
Paci, AM	1
Pieroni, A	1
Baria, L	1
Tommasi, SM	1
Watabe, A	1
Saito, H	1
Harasawa, K	1
Morimoto, Y	1
Koczmara, C	1
Hyland, S	1
Greenall, J	1
Pietrucha, A	1
Piwowarska, W	1
Wang, Y	1
Cai, HY	1
Ma, TK	1
Tao, SM	1
Sun, S	1
Chen, MQ	1
Gu, Y	1
Pang, JH	1
Xiao, JM	1
Yang, XY	1
Yang, C	1
Summers, MR	1
Lerman, A	2
Lennon, RJ	1
Rihal, CS	1
Prasad, A	1
Brugaletta, S	1
Heo, JH	1
Garcia-Garcia, HM	1
Farooq, V	1
van Geuns, RJ	1
de Bruyne, B	1
Dudek, D	1
Smits, PC	1
Koolen, J	1
McClean, D	1
Dorange, C	1
Veldhof, S	1
Rapoza, R	1
Onuma, Y	1
Bruining, N	1
Ormiston, JA	1
Serruys, PW	1
Fukuma, N	1
Kato, K	1
Munakata, K	1
Hayashi, H	1
Kato, Y	1
Aisu, N	1
Takahashi, H	1
Mabuchi, K	1
Mizuno, K	1
Wei, J	1
Mehta, PK	1
Samuels, B	1
Kar, S	1
Anderson, RD	1
Azarbal, B	1
Petersen, J	1
Sharaf, B	1
Handberg, E	2
Shufelt, C	1
Kothawade, K	1
Sopko, G	3
Shaw, L	1
Kelsey, SF	2
Merz, CN	1
Mitka, M	1
Pinelli, A	1
Trivulzio, S	1
Tomasoni, L	1
Bertolini, B	1
Brenna, S	1
Bonacina, E	1
Isobe, N	1
Oshima, S	1
Taniguchi, K	1
Hoshizaki, H	1
Adachi, H	1
Toyama, T	1
Naito, S	1
Nogami, A	1
Sugawara, M	1
Shry, EA	1
Dacus, J	1
Van De Graaff, E	1
Hjelkrem, M	1
Stajduhar, KC	1
Steinhubl, SR	1
Thuny, F	1
Dieuzaide, P	1
Avierinos, JF	1
Collart, F	1
Quilici, J	1
Franceschi, F	1
Sbragia, P	1
Habib, G	1
Bonnet, JL	1
Mesana, T	1
López de la Iglesia, J	1
Martínez Ramos, E	1
Pardo Franco, L	1
Escudero Alvarez, S	1
Cañón de la Parra, RI	1
Costas Mira, MT	1
Longobardi, G	1
Ferrara, N	1
Abete, P	1
Leosco, D	1
Furgi, G	1
Nicolino, A	1
Vitale, DF	1
Rengo, F	2
Kumar, K	1
Nguyen, K	1
Waxman, S	1
Nearing, BD	1
Wellenius, GA	1
Zhao, SX	1
Verrier, RL	1
Kula, M	1
Tutuş, A	1
Unal, S	1
Topsakal, R	1
Ergin, A	1
Jessurun, GA	1
Hautvast, RW	2
Tio, RA	1
DeJongste, MJ	1
Bianco, JA	1
Ushkalova, EA	1
Idrisova, EM	1
Borovkova, NV	1
Kladieva, EA	1
Chernov, VI	2
Demochko, AV	1
Shishkina, AA	1
Vorob'eva, EV	1
Karpov, RS	1
Lanzarini, L	1
Scelsi, L	1
Canosi, U	1
Klersy, C	1
Sebastiani, R	1
Previtali, M	1
Chaitman, BR	1
Parker, JO	3
Skopal, J	1
Chumakova, G	1
Kuch, J	1
Wang, W	1
Skettino, SL	1
Wolff, AA	1
von Mering, GO	2
Arant, CB	1
Wessel, TR	1
McGorray, SP	2
Sharaf, BL	1
Smith, KM	1
Olson, MB	1
Kerensky, RA	2
Faggian, F	1
Lattuada, E	1
Lanzafame, M	1
Trevenzoli, M	1
Cattelan, AM	1
Concia, E	1
Kataoka, T	1
Hamasaki, S	1
Ishida, S	1
Saihara, K	1
Okui, H	1
Fukudome, T	1
Shinsato, T	1
Mizoguchi, E	1
Ninomiya, Y	1
Otsuji, Y	1
Minagoe, S	1
Tei, C	1
Wu, X	1
Wang, CF	1
Sheng, J	1
Zhu, J	1
Schulman, SP	1
Freimark, D	1
Feinberg, MS	1
Matezky, S	1
Hochberg, N	1
Shechter, M	1
Tepliakov, AT	1
Rybal'chenko, EV	1
Krylov, AL	1
Stepacheva, TA	1
Vesnina, ZhV	1
D'iakova, ML	1
Matthews, MA	1
Kunselman, SJ	1
Gascho, JA	1
Gilchrist, IC	1
Jneid, H	1
Chandra, M	1
Alshaher, M	1
Hornung, CA	1
Tang, XL	2
Leesar, M	1
Bolli, R	2
Martsevich, SIu	1
Shangina, OA	1
Kostin, VI	1
Koturga, LI	1
Fan, Q	2
Gao, F	2
Zhang, L	1
Christopher, TA	1
Lopez, BL	1
Ma, XL	1
Daiber, A	1
Mülsch, A	1
Hink, U	1
Mollnau, H	1
Warnholtz, A	1
Oelze, M	1
Münzel, T	1
Patterson, D	1
Kloner, R	1
Effron, M	1
Emmick, J	1
Bedding, A	1
Warner, M	1
Mitchell, M	1
Braat, S	2
MacDonald, T	1
Patel, AR	1
Kuvin, JT	1
Sliney, KA	1
Rand, WM	1
Pandian, NG	1
Karas, RH	1
Beckerman, B	1
Kazachkina, SS	1
Balakhonova, TV	1
Lupanov, VP	1
Pogorelova, OA	1
Rogoza, AN	1
Naumov, VG	1
Iliodromitis, EK	1
Gaitanaki, C	1
Lazou, A	1
Aggeli, IK	1
Gizas, V	1
Bofilis, E	1
Zoga, A	1
Beis, I	1
Kremastinos, DT	1
Yang, XC	1
Cao, XB	1
Wang, SY	1
Yang, SL	1
Liu, XL	1
Bin, JP	1
Doctor, A	1
Lindner, J	1
Hendersen, EM	1
Le, DE	1
Leong-Poi, H	1
Fisher, NG	1
Christiansen, J	1
Kaul, S	1
Siński, M	1
Lewandowski, J	1
Abramczyk, P	1
Nowosad, H	1
Grzelak-Szafrańiska, H	1
Morii, H	1
Naito, N	1
Nakano, K	1
Kanamasa, K	1
Niyaz, K	1
Niaz, K	1
Zaman, MU	1
Kamal, S	1
Usmani, S	1
Habib, S	1
Hashmi, H	1
Husssain, SW	1
Lascano, EC	1
Valle, HF	1
Negroni, JA	1
Pohost, G	1
Rogers, WJ	1
Minin, SM	1
Makarova, EV	1
Krivoshchekov, EV	1
Lishmanov, IuB	1
Wierzbicki, K	1
Przybyłowski, P	1
Sobczyk, D	1
Konstanty, J	1
Kapelak, B	1
Drwiła, R	1
Krochin, M	1
Podolec, P	1
Wójcik, S	1
Marek, G	1
Wróbel, K	1
Piatek, J	1
Rudziński, P	1
Sadowski, J	1
Krüger, D	2
Al Mokhtari, NE	1
Wieckhorst, A	1
Rausche, T	1
Simon-Herrmann, G	1
Simon, R	1
Nakae, I	1
Quan, L	1
Sugimoto, Y	1
Tsutamoto, T	1
Ferraro, S	1
Ambrosio, G	1
Codella, C	1
Liguori, L	1
Trimigliozzi, P	1
Maddalena, G	1
Desiderio, A	1
Chiariello, M	1
Koh, KK	1
Park, GS	1
Song, JH	1
Moon, TH	1
In, HH	1
Kim, JJ	1
Lee, HJ	1
Cho, SK	1
Kim, SS	1
Przyklenk, K	1
Kloner, RA	1
Szilvássy, Z	3
Csonka, C	1
Nagy, E	1
Koltai, M	2
Dux, L	2
Batlouni, M	1
Mathew, J	1
Thannoli, N	1
Narra, L	1
el Khadra, M	1
Seleznev, MN	1
Iakovlev, VF	1
Flerov, EV	1
Buniamian, AA	1
Khosla, S	1
Coutinho, NB	1
Megellas, MM	1
Mukherjee, D	1
Somberg, JC	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235]	Phase 2	60 participants (Actual)	Interventional	2011-07-31	Completed
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction[NCT00832702]		433 participants (Anticipated)	Observational	2008-09-17	Active, not recruiting
[NCT00000554]	Phase 3	0 participants	Interventional	2001-05-31	Completed
Non-invasive Fractional Flow Reserve CT (FFRCT) Scan for the Study of Coronary Vaso-motion[NCT02809157]		10 participants (Anticipated)	Observational	2014-10-31	Active, not recruiting
The Effects of Traditional Acupuncture on Mechanisms of Coronary Heart Disease[NCT00570024]		145 participants (Actual)	Interventional	2006-01-31	Completed
WISE Ancillary Study Data Analyses: Efficacy of Hormone Replacement on Myocardial Ischemia in Postmenopausal Women With Normal/Minimal Coronary Artery Disease: Data Analysis[NCT00600106]		37 participants (Actual)	Interventional	1999-12-31	Completed
Randomized, Double-Blind, Active-Controlled, Multicenter Trial of Abciximab And Bivalirudin in Patients With Non-ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Interventions (ISAR-REACT-4)[NCT00373451]	Phase 4	1,721 participants (Actual)	Interventional	2006-07-31	Completed
Comparative Randomized Single-blind Trial of Amiloride in Coronary Heart Disease[NCT01231165]	Phase 2/Phase 3	70 participants (Actual)	Interventional	2009-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of endothelial dysfunction.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: Baseline

Endothelial Dysfunction (FMD)

Intervention	percentage of pre-stimulus diameter (Mean)
Hormone Replacement Therapy	8.2
Placebo	8.8

"Endothelial dysfunction refers to altered vasoactive, anticoagulant, and anti-inflammatory properties of endothelium, and dysregulated vascular growth remodeling that results from a loss of nitric oxide (NO) bioactivity in the endothelium. Brachial Artery Reactivity Testing (BART), high-frequency ultrasonographic imaging of the brachial artery, evaluates flow-mediated vasodilation (FMD), an endothelium-dependent function. The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function.~Flow-mediated vasodilation is typically expressed as the change in post-stimulus diameter as a percentage of the baseline diameter [diameter after cuff deflation - baseline diameter / baseline diameter) x 100]." (NCT00600106)
Timeframe: 12 weeks

Inducible Myocardial Ischemia

Intervention	percentage of pre-stimulus diameter (Mean)
Hormone Replacement Therapy	8.8
Placebo	7.3

Inducible myocardial ischemia measured by P-31 gated magnetic resonance cardiac spectroscopy (MRS) is reported as change (∆) in PCr/ATP ratio, with isometric submaximal handgrip stress. PCr/ATP ratio defined as (stress-[average of rest and recovery periods]) / average of rest and recover periods X 100, and expressed as % mean ± SD. For this trial, myocardial ischemia was pre-specified as a fall in quantitative PCR/ATP ratio >20% from rest, and a lower value is considered indicative of greater ischemia. (NCT00600106)
Timeframe: 12 weeks

Inducible Myocardial Ischemia

Intervention	percent change in PCR/ATP ratio (Mean)
Hormone Replacement Therapy	-7.7
Placebo	1.1

Physical Functional Disability - Functional Capacity (Exercise Induced ST Segment Depression)

Intervention	percent changed in PCR/ATP ratio (Mean)
Hormone Replacement Therapy	-13.8
Placebo	-7.0

"Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain.~In electrocardiography, the ST segment connects the QRS complex and the T wave and has duration of 80 to 120 ms. It should be essentially level with the PR and TP segment. The normal ST segment has a slight upward concavity. Flat, downsloping, or depressed ST segment may indicate coronary ishcemia. Positive treadmill exercise stress test (>1.0 mm horizontal / downsloping or >1.5 upsloping ST segment depression measured 0.08 msec after the J point)." (NCT00600106)
Timeframe: Baseline

Physical Functional Disability - Functional Capacity (Metabolism Equivalents)

Intervention	mm (Mean)
Hormone Replacement Therapy	-0.79
Placebo	-0.79

Intervention	metabolism equivalents (Mean)
Hormone Replacement Therapy	6.1
Placebo	5.8

Physical Functional Disability - Functional Capacity (METs)

Intervention	metabolism equivalents (Mean)
Hormone Replacement Therapy	6.1
Placebo	5.4

Physical functional disability measured by exercise stress testing. Functional capacity was measured as metabolism equivalents (METs), exercise duration, and exercise-induced chest pain. A MET is defined as the resting metabolic rate, that is, the amount or oxygen consumet at rest, sitting quietly in a chair, approximately 3.5 ml O2 / kg / min (1.2 kcallmin for a 70-kg person). As such, work at METs requires twice the resting metabolism or 7.0 ml O2/kg/min, and so on. (NCT00600106)
Timeframe: Baseline

Physical Functional Disability - Functional Capacity (METs)

Intervention	metabolism equivalents (Mean)
Hormone Replacement Therapy	5.4
Placebo	5.4

Physical Functional Disability - Functional Capacity (Stress Induced ST Segment Depression)

Intervention	metabolism equivalents (Mean)
Hormone Replacement Therapy	6.1
Placebo	5.4

Quality of Life - Health Survey

Intervention	mm (Mean)
Hormone Replacement Therapy	-1.05
Placebo	-0.63

"Quality of life assessed by cardiac symptoms and psychological questionnaires (SF 36 scale - Short Form Health Survey) The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions.~Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability." (NCT00600106)
Timeframe: 12 weeks

Quality of Life - Health Survey

Intervention	units on a scale (Mean)
	Physical functioning	Role-physical	Role-emotional	Bodily pain	General health	Mental health	Vitality	Social functioning
Hormone Replacement Therapy	59.4	58.8	76.5	54.5	55.2	66.4	35.6	59.4
Placebo	44.4	25.0	66.7	41.5	57.2	69.3	41.2	56.1

Quality of Life - Menopause Symptoms

Intervention	units on a scale (Mean)
	Physical functioning	Role-physical	Role-emotional	Bodily pain	General health	Mental health	Vitality	Social functioning
Hormone Replacement Therapy	60.8	54.2	70.3	53.3	55.4	66.7	35.6	59.4
Placebo	43.8	37.3	66.7	42.1	57.4	65.7	42.9	53.2

Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: 12 weeks

Quality of Life - Menopause Symptoms

Intervention	percent of participants (Number)
	Hot flushes or flashing	Poor memory	Change in sexual desire	Vaginal dryness	Avoiding intimacy
Hormone Replacement Therapy	41	59	35	35	24
Placebo	89	78	67	67	56

Quality of life assessed by menopausal symptoms and psychological questionnaires (NCT00600106)
Timeframe: Baseline

Article	Year
Efficacy of prophylactic doses of intravenous nitroglycerin in preventing myocardial ischemia under general anesthesia: A systematic review and meta-analysis with trial sequential analysis. Journal of clinical anesthesia, 2017, Volume: 40 Topics: Anesthesia, General; Hemodynamics; Humans; Infusions, Intravenous; Intraoperative Complications; Myo	2017
Use of nitrates in ischemic heart disease. Expert opinion on pharmacotherapy, 2015, Volume: 16, Issue:11 Topics: Angina Pectoris; Coronary Artery Disease; Delayed-Action Preparations; Drug Tolerance; Humans; Myoca	2015
Role of short-acting nitroglycerin in the management of ischemic heart disease. Drug design, development and therapy, 2015, Volume: 9 Topics: Administration, Sublingual; Aerosols; Animals; Chemistry, Pharmaceutical; Coronary Circulation; Exer	2015
Clinical effect of cardiac shock wave therapy on patients with ischaemic heart disease: a systematic review and meta-analysis. European journal of clinical investigation, 2015, Volume: 45, Issue:12 Topics: Aged; Clinical Trials as Topic; Female; High-Energy Shock Waves; Humans; Male; Middle Aged; Myocardi	2015
The effects of medications on myocardial perfusion. Journal of the American College of Cardiology, 2008, Aug-05, Volume: 52, Issue:6 Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Cardiovascular Agents; Humans; Hydroxymethylg	2008
[Intravenous nitroglycerin in cardiology]. Kardiologiia, 2003, Volume: 43, Issue:9 Topics: Humans; Hypertension; Infusions, Intravenous; Myocardial Ischemia; Nitroglycerin; Vasodilator Agents	2003
[Nitrates. The place in contemporary therapy of ischemic heart disease]. Kardiologiia, 2005, Volume: 45, Issue:7 Topics: Angina Pectoris; Contraindications; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Myoca	2005
The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine. The American journal of cardiology, 2005, Oct-10, Volume: 96, Issue:7B Topics: Animals; Clinical Trials as Topic; Coronary Angiography; Disease Models, Animal; Dose-Response Relat	2005
[Nitroglycerin: secular drug always current]. Arquivos brasileiros de cardiologia, 1994, Volume: 63, Issue:6 Topics: Animals; Cardiac Output, Low; Coronary Circulation; Drug Tolerance; Humans; Myocardial Ischemia; Nit	1994
Nitrates for unstable angina. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:5 Topics: Administration, Oral; Administration, Topical; Adrenergic beta-Antagonists; Angina, Unstable; Calciu	1994
[Importance of thiols (SH group) in the cardiovascular system]. Ugeskrift for laeger, 1993, Nov-08, Volume: 155, Issue:45 Topics: Cardiovascular System; Glutathione; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitr	1993
Cocaine-associated myocardial infarction. Journal of the Royal Society of Medicine, 1996, Volume: 89, Issue:8 Topics: Adult; Aged; Aspirin; Benzodiazepines; Cocaine; Humans; Middle Aged; Myocardial Infarction; Myocardi	1996
[Evidence-based pharmacological therapy of ischemic heart disease: with reference to the long-term prognosis]. Journal of cardiology, 1998, Volume: 31, Issue:2 Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Evidence-Based Medicine; Humans; Myocardial I	1998
The 'vasovagal effect' of nitrates: an under-recognised complication of nitrate use. International journal of clinical practice, 1998, Volume: 52, Issue:6 Topics: Adult; Bradycardia; Humans; Hypotension; Isosorbide Dinitrate; Male; Myocardial Ischemia; Nitroglyce	1998
[Nitrates in cardiology practice]. Casopis lekaru ceskych, 2000, Jun-07, Volume: 139, Issue:11 Topics: Humans; Isosorbide Dinitrate; Molsidomine; Myocardial Ischemia; Nitroglycerin; Vasodilator Agents	2000

Article	Year
Effects of Nicorandil Versus Nitroglycerin on Arterial Oxygenation During Two-Lung Ventilation and One-Lung Ventilation in Patients With Risk Factors for Myocardial Ischemia: A Prospective, Randomized, Double-Blind Study. Journal of cardiothoracic and vascular anesthesia, 2019, Volume: 33, Issue:3 Topics: Aged; Aged, 80 and over; Blood Gas Analysis; Double-Blind Method; Female; Humans; Male; Myocardial I	2019
Comparison between Glyceryl Trinitrate and Trimetazidine in Ischaemic Cardiomyopathy Patients. Mymensingh medical journal : MMJ, 2019, Volume: 28, Issue:1 Topics: Bangladesh; Cardiomyopathies; Humans; Male; Myocardial Contraction; Myocardial Ischemia; Nitroglycer	2019
Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease. Coronary artery disease, 2015, Volume: 26, Issue:8 Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Human	2015
Endothelial-dependent vasomotion in a coronary segment treated by ABSORB everolimus-eluting bioresorbable vascular scaffold system is related to plaque composition at the time of bioresorption of the polymer: indirect finding of vascular reparative therap European heart journal, 2012, Volume: 33, Issue:11 Topics: Absorbable Implants; Acetylcholine; Aged; Coronary Vessels; Drug-Eluting Stents; Endothelium, Vascul	2012
Nicorandil infusion leads to good recovery from ischemia of left ventricular regional work in comparison with nitroglycerin. Circulation journal : official journal of the Japanese Circulation Society, 2002, Volume: 66, Issue:10 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Electrocardiography;	2002
Efficacy of transdermal nitroglycerin patches evaluated by dipyridamole-induced myocardial ischemia in patients with coronary artery disease. Comparison between continuous and intermittent schedule. Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:6 Topics: Administration, Cutaneous; Aged; Coronary Artery Disease; Cross-Over Studies; Dipyridamole; Double-B	2002
Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium-201. Nuclear medicine communications, 2003, Volume: 24, Issue:9 Topics: Adult; Aged; Coronary Artery Disease; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myo	2003
Electrical neuromodulation improves myocardial perfusion and ameliorates refractory angina pectoris in patients with syndrome X: fad or future? European journal of pain (London, England), 2003, Volume: 7, Issue:6 Topics: Adult; Angina Pectoris; Coronary Circulation; Dipyridamole; Female; Humans; Male; Microvascular Angi	2003
[Nitrates in therapy of effort angina in hypotensive patients]. Klinicheskaia meditsina, 2003, Volume: 81, Issue:11 Topics: Angina Pectoris; Cross-Over Studies; Exercise Test; Humans; Hypotension; Isosorbide Dinitrate; Male;	2003
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA, 2004, Jan-21, Volume: 291, Issue:3 Topics: Acetanilides; Adrenergic beta-Antagonists; Aged; Amlodipine; Angina Pectoris; Atenolol; Calcium Chan	2004
Impact of short-term intermittent intravenous dobutamine therapy on endothelial function in patients with severe chronic heart failure. American heart journal, 2004, Volume: 148, Issue:5 Topics: Adrenergic beta-Agonists; Adult; Aged; Brachial Artery; Dobutamine; Drug Therapy, Combination; Endot	2004
Delayed preconditioning-mimetic actions of nitroglycerin in patients undergoing exercise tolerance tests. Circulation, 2005, May-24, Volume: 111, Issue:20 Topics: Aged; Coronary Artery Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Me	2005
The effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease. British journal of clinical pharmacology, 2005, Volume: 60, Issue:5 Topics: Aged; Analysis of Variance; Blood Pressure; Carbolines; Coronary Artery Disease; Cross-Over Studies;	2005
An open multicenter efficacy and safety evaluation of amlodipine in the treatment of symptomatic myocardial ischemia. Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 1 Topics: Adult; Aged; Amlodipine; Blood Pressure; Calcium Channel Blockers; Drug Administration Schedule; Fem	1991
[Comparison of the effect of nitroglycerine and pentaerithritol compositum on exercise time restricted by anginal pain or objective parameters of ischaemia in patients with stable angina]. Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 114, Issue:2 Topics: Aged; Angina Pectoris; Chest Pain; Double-Blind Method; Exercise Test; Female; Humans; Male; Middle	2005
Inhibition of nitrate tolerance without reducing vascular response during eccentric dosing of nitrates. Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:10 Topics: Administration, Cutaneous; Administration, Oral; Administration, Sublingual; Adult; Aged; Angiotensi	2006
Markers of pulmonary hypertension in potential candidates to heart transplantation. Przeglad lekarski, 2006, Volume: 63, Issue:12 Topics: Adult; Biomarkers; Cardiomyopathy, Dilated; Dose-Response Relationship, Drug; Drug Resistance; Femal	2006
[ECG-dipyridamole and ECG-exercise test in the assessment of ischemic cardiopathy: effects of the acute administration of nitroglycerin]. Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:4 Topics: Dipyridamole; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Isch	1995
Interaction of intravenous heparin and organic nitrates in acute ischemic syndromes. The American journal of cardiology, 1995, Oct-01, Volume: 76, Issue:10 Topics: Acute Disease; Aged; Analysis of Variance; Anticoagulants; Antithrombin III; Drug Interactions; Fema	1995
Reactivity of coronary arteries in relation to serum magnesium levels in patients with ischaemic heart disease--a quantitative coronary angiographic study. Magnesium research, 1995, Volume: 8, Issue:1 Topics: Adult; Aged; Coronary Angiography; Coronary Vessels; Female; Humans; Magnesium; Male; Middle Aged; M	1995
[Prevention of myocardial ischemia. Study following aortocoronary bypass operation with the calcium antagonist diltiazem]. Der Anaesthesist, 1995, Volume: 44, Issue:2 Topics: Adult; Aged; Coronary Artery Bypass; Diltiazem; Female; Hemodynamics; Humans; Male; Middle Aged; Myo	1995
[Clinical evaluation of prophylactic nitroglycerin infusion during coronary artery bypass grafting]. Masui. The Japanese journal of anesthesiology, 1995, Volume: 44, Issue:4 Topics: Anesthesia, General; Cardiopulmonary Bypass; Catecholamines; Coronary Artery Bypass; Creatine Kinase	1995
Intermittent transdermal nitrates do not improve ischemia in patients taking beta-blockers or calcium antagonists: potential role of rebound ischemia during the nitrate-free period. Journal of the American College of Cardiology, 1995, Volume: 25, Issue:2 Topics: Administration, Cutaneous; Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Calcium Channel B	1995
Intermittent transdermal nitroglycerin therapy in angina pectoris. Clinically effective without tolerance or rebound. Minitran Efficacy Study Group. Circulation, 1995, Mar-01, Volume: 91, Issue:5 Topics: Administration, Cutaneous; Angina Pectoris; Dose-Response Relationship, Drug; Double-Blind Method; D	1995
Redistribution of myocardial blood flow with topical nitroglycerin in patients with coronary artery disease. Circulation, 1995, Mar-01, Volume: 91, Issue:5 Topics: Administration, Cutaneous; Ammonia; Angina Pectoris; Coronary Circulation; Deoxyglucose; Double-Blin	1995
Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind Circadian Anti-Ischemia Program in Europe (CAPE Trial). Journal of the American College of Cardiology, 1994, Nov-15, Volume: 24, Issue:6 Topics: Adult; Aged; Amlodipine; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Drug T	1994
Effects of nitroglycerin by technetium-99m sestamibi tomoscintigraphy on resting regional myocardial hypoperfusion in stable patients with healed myocardial infarction. The American journal of cardiology, 1994, Nov-01, Volume: 74, Issue:9 Topics: Coronary Circulation; Echocardiography; Female; Heart; Humans; Male; Middle Aged; Myocardial Contrac	1994
Transdermal nitroglycerin patch therapy reduces the extent of exercise-induced myocardial ischemia: results of a double-blind, placebo-controlled trial using quantitative thallium-201 tomography. Journal of the American College of Cardiology, 1994, Volume: 24, Issue:1 Topics: Administration, Cutaneous; Aged; Angina Pectoris; Chi-Square Distribution; Double-Blind Method; Elec	1994
Nitroglycerin in the treatment of cocaine associated chest pain--clinical safety and efficacy. Journal of toxicology. Clinical toxicology, 1994, Volume: 32, Issue:3 Topics: Adult; Chest Pain; Cocaine; Female; Follow-Up Studies; Hemodynamics; Humans; Male; Myocardial Infarc	1994
Clinical response to intravenous nitroglycerin infused through polyethylene or polyvinyl chloride tubing. American journal of hospital pharmacy, 1994, Feb-15, Volume: 51, Issue:4 Topics: Aged; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Morphine; Myocardial Ischemia; Nitr	1994
Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting. The Journal of thoracic and cardiovascular surgery, 1994, Volume: 107, Issue:3 Topics: Arrhythmias, Cardiac; Biomarkers; Coronary Artery Bypass; Creatine Kinase; Diltiazem; Echocardiograp	1994
Influence of glyceryl trinitrate on venous and arterial effects of chronic, asymmetric isosorbide dinitrate treatment in patients with ischemic heart disease. Clinical cardiology, 1994, Volume: 17, Issue:2 Topics: Aged; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Exercise	1994
Efficacy of long-term administration of transdermal nitroglycerin in asymptomatic patients with effort-induced silent myocardial ischemia. Cardiology, 1994, Volume: 84, Issue:4-5 Topics: Administration, Cutaneous; Adult; Aged; Coronary Disease; Double-Blind Method; Drug Administration S	1994
Investigation of therapeutic mechanisms of atenolol and diltiazem in patients with variable-threshold angina. American heart journal, 1994, Volume: 127, Issue:2 Topics: Aged; Angina Pectoris, Variant; Atenolol; Blood Pressure; Coronary Angiography; Diltiazem; Double-Bl	1994
Ischemia in collateral-dependent myocardium: effects of nifedipine and diltiazem in man. American heart journal, 1993, Volume: 126, Issue:1 Topics: Aged; Blood Pressure; Collateral Circulation; Coronary Disease; Diltiazem; Electrocardiography; Exer	1993
Transdermal nitroglycerin reduces the frequency of anginal attacks but fails to prevent silent ischemia. Journal of the American College of Cardiology, 1993, Volume: 21, Issue:2 Topics: Administration, Cutaneous; Angina Pectoris; Double-Blind Method; Drug Administration Schedule; Drug	1993
Prophylactic nitroglycerin infusion during noncardiac surgery does not reduce perioperative ischemia. Anesthesia and analgesia, 1993, Volume: 76, Issue:4 Topics: Aged; Blood Pressure; Coronary Disease; Double-Blind Method; Electrocardiography, Ambulatory; Female	1993
Diltiazem provides anti-ischemic and anti-arrhythmic protection in patients undergoing coronary bypass grafting. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1993, Volume: 7, Issue:5 Topics: Arrhythmias, Cardiac; Coronary Artery Bypass; Creatine Kinase; Diltiazem; Electrocardiography, Ambul	1993
Early postoperative myocardial ischemia after coronary artery bypass grafting. Detrimental effects of nitroglycerine infusion. Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:11 Topics: Aged; Coronary Artery Bypass; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged;	1995
Beneficial cumulative role of both nitroglycerin and dobutamine on right ventricular systolic function in congestive heart failure patients awaiting heart transplantation. International journal of cardiology, 1995, Nov-10, Volume: 52, Issue:1 Topics: Cardiomyopathy, Dilated; Cardiotonic Agents; Dobutamine; Drug Therapy, Combination; Female; Heart Fa	1995
The effect of midazolam at two plasma concentrations of hemodynamics and sufentanil requirement in coronary artery surgery. Journal of cardiothoracic and vascular anesthesia, 1996, Volume: 10, Issue:3 Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthesia Recovery Period;	1996
Effect of pre-treatment with transdermal glyceryl trinitrate on myocardial ischaemia during coronary angioplasty. Heart (British Cardiac Society), 1996, Volume: 76, Issue:6 Topics: Administration, Cutaneous; Angioplasty, Balloon, Coronary; Coronary Disease; Coronary Vessels; Doubl	1996
Allergic reactions to local glyceryl trinitrate administration. The British journal of clinical practice, 1996, Volume: 50, Issue:8 Topics: Adhesives; Administration, Cutaneous; Aged; Angina Pectoris; Dermatitis, Contact; Drug Administratio	1996
Effects of intermittent transdermal nitroglycerin on occurrence of ischemia after patch removal: results of the second transdermal intermittent dosing evaluation study (TIDES-II). Journal of the American College of Cardiology, 1997, Volume: 30, Issue:4 Topics: Administration, Cutaneous; Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Calcium Channe	1997
Cardioprotective effects of diltiazem infusion in the perioperative period. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1997, Volume: 12, Issue:3 Topics: Aged; Arrhythmias, Cardiac; Cardiovascular Agents; Coronary Artery Bypass; Diltiazem; Double-Blind M	1997
Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance. Circulation, 1997, Oct-21, Volume: 96, Issue:8 Topics: Administration, Oral; Adult; Aged; Antioxidants; Blood Platelets; Cyclic GMP; Double-Blind Method; D	1997
Efficacy of mibefradil compared with amlodipine in suppressing exercise-induced and daily silent ischemia: results of a multicenter, placebo-controlled trial. Circulation, 1997, Oct-21, Volume: 96, Issue:8 Topics: Adult; Aged; Amlodipine; Angina Pectoris; Benzimidazoles; Double-Blind Method; Electrocardiography,	1997
[The evaluation of the effect of venodilatation in 2 different systems of transdermal nitroglycerin release]. Recenti progressi in medicina, 1997, Volume: 88, Issue:9 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analysis of Variance; Drug Delivery Systems; Fem	1997
Antianginal efficacy over 24 hours and exercise hemodynamic effects of once daily sustained-release 300 mg diltiazem and 240 mg verapamil in stable angina pectoris. International journal of cardiology, 1998, Jan-05, Volume: 63, Issue:1 Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Di	1998
Intravenous nitroglycerin reduces ischaemia in unstable angina pectoris: a double-blind placebo-controlled study. Journal of internal medicine, 1998, Volume: 243, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Double-Blind Method; Female; Humans; Incidence; In	1998
[Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance]. Journal of cardiology, 1998, Volume: 31, Issue:3 Topics: Aged; Antioxidants; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Humans; Male; Mi	1998
Randomized, double-blind, placebo-controlled study of the preventive effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance. Journal of the American College of Cardiology, 1998, Volume: 31, Issue:6 Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cyclic GMP; Double-Blind Method; Drug Therapy, Combination	1998
Increasing nitroglycerin release from patches enables circumvention of early nitrate tolerance. Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:2 Topics: Adult; Blood Pressure; Coronary Disease; Electrocardiography; Exercise; Half-Life; Hemodynamics; Hum	1998
Does sublingual 17 beta-oestradiol have any effects on exercise capacity and myocardial ischaemia in post-menopausal women with stable coronary artery disease? European heart journal, 1998, Volume: 19, Issue:7 Topics: Administration, Sublingual; Coronary Disease; Cross-Over Studies; Double-Blind Method; Electrocardio	1998
Antiischemic effects of nicardipine and nitroglycerin after coronary artery bypass grafting. The Annals of thoracic surgery, 1999, Volume: 67, Issue:2 Topics: Aged; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Electrocardiograph	1999
Effects of nicardipine and nitroglycerin on perioperative myocardial ischemia in patients undergoing coronary artery bypass surgery. Seminars in thoracic and cardiovascular surgery, 1999, Volume: 11, Issue:2 Topics: Calcium Channel Blockers; Coronary Artery Bypass; Female; Hemodynamics; Humans; Male; Middle Aged; M	1999
A new clinical application of nitroglycerin as an aid to venipuncture in nitroglycerin tape users. Anesthesia and analgesia, 2000, Volume: 90, Issue:2 Topics: Administration, Topical; Humans; Injections, Intravenous; Myocardial Ischemia; Nitroglycerin; Phlebo	2000
Prophylactic nitroglycerin did not reduce myocardial ischemia during accelerated recovery management of coronary artery bypass graft surgery patients. Journal of cardiothoracic and vascular anesthesia, 2000, Volume: 14, Issue:5 Topics: Adult; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial In	2000
Efficacy of anti-anginal drugs in the treatment of angina pectoris associated with silent myocardial ischemia: importance of quantitative Holter ECG data for patient activity. Internal medicine (Tokyo, Japan), 2000, Volume: 39, Issue:12 Topics: Administration, Cutaneous; Aged; Angina Pectoris; Coronary Angiography; Cross-Over Studies; Double-B	2000
Diltiazem versus nitroglycerin for myocardial protection following coronary artery bypass grafting as assessed by dobutamine stress echocardiography. Wiener klinische Wochenschrift, 2001, Jun-15, Volume: 113, Issue:11-12 Topics: Adrenergic beta-Agonists; Aged; Coronary Artery Bypass; Diltiazem; Dobutamine; Echocardiography; Fem	2001

Article	Year
A Rare Case of Vasospasm Presenting with Acute Coronary Syndrome and Leading to Total Occlusion. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2023, Volume: 51, Issue:6 Topics: Acute Coronary Syndrome; Angina Pectoris; Constriction, Pathologic; Coronary Vasospasm; Humans; Male	2023
ST Elevation During Recovery Phase of Exercise Test. The American journal of medicine, 2020, Volume: 133, Issue:11 Topics: Aged; Bradycardia; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Electrocardiogra	2020
Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries. Journal of clinical ultrasound : JCU, 2021, Volume: 49, Issue:4 Topics: Adult; Aged; Brachial Artery; Coronary Vessels; Cytokines; Dilatation, Pathologic; Endothelium, Vasc	2021
A patient with relapsing myocardial ischaemia. Acta cardiologica, 2017, Volume: 72, Issue:3 Topics: Coronary Angiography; Coronary Vasospasm; Coronary Vessels; Electrocardiography; Humans; Injections,	2017
Open-Label Study of the Stability of Sublingual Nitroglycerin Tablets in Simulated Real-Life Conditions. The American journal of cardiology, 2018, 12-15, Volume: 122, Issue:12 Topics: Administration, Sublingual; Drug Packaging; Drug Stability; Humans; Myocardial Ischemia; Nitroglycer	2018
Revascularization Rates and Associated Costs in Patients With Stable Ischemic Heart Disease Initiating Ranolazine Versus Traditional Antianginals as Add-on Therapy. The American journal of cardiology, 2019, 05-15, Volume: 123, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cost-Benefit Analysis; Delayed-Action Preparations; Fema	2019
Myocardial postconditioning is lost in vascular nitrate tolerance. Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:3 Topics: Animals; Coronary Circulation; Coronary Vessels; Drug Tolerance; Endothelium, Vascular; Enzyme Activ	2013
Brachial artery constriction during brachial artery reactivity testing predicts major adverse clinical outcomes in women with suspected myocardial ischemia: results from the NHLBI-sponsored women's ischemia Syndrome Evaluation (WISE) Study. PloS one, 2013, Volume: 8, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Brachial Artery; Female; Follow-Up Studies; Humans; Middle Aged; Mod	2013
Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1: intravital microscopic observation and (31)P-MR spectroscopic studies. Life sciences, 2014, Nov-24, Volume: 118, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Cardi	2014
Changes in pulmonary hemodynamics induced by experimental myocardial ischemia in nitroglycerin- or acetylcholine-treated rabbits. Bulletin of experimental biology and medicine, 2014, Volume: 157, Issue:4 Topics: Acetylcholine; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Heart Atria; Hemodynamic	2014
The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: role of incorporating PR prolongation. Atherosclerosis, 2014, Volume: 237, Issue:2 Topics: Aged; Atrial Fibrillation; Body Mass Index; Cardiovascular Diseases; Carotid Intima-Media Thickness;	2014
Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure. Irish medical journal, 2015, Volume: 108, Issue:3 Topics: Administration, Topical; Anesthetics, Local; Cardiovascular Agents; Cocaine; Diagnostic Techniques,	2015
Intermittent Nitrate Use and Risk of Hip Fracture. The American journal of medicine, 2017, Volume: 130, Issue:2 Topics: Aged; Angina, Stable; Female; Hip Fractures; Humans; Isosorbide Dinitrate; Kaplan-Meier Estimate; Ma	2017
Conservative medication follow-up for over 20 years of a patient with ischemic heart disease after diagnosis of chronic total occlusion of the 3 main coronary arteries. Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:7 Topics: Acute Coronary Syndrome; Administration, Sublingual; Angina Pectoris; Antihypertensive Agents; Chron	2008
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels. International journal of cardiology, 2009, Jun-26, Volume: 135, Issue:2 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin	2009
Viable myocardium scintigraphy with intravenous nitroglycerine by computed tomography with Tc-99m (MIBI). Arquivos brasileiros de cardiologia, 2008, Volume: 91, Issue:3 Topics: Adult; Aged; Blood Pressure; Chi-Square Distribution; Coronary Circulation; Female; Heart Rate; Huma	2008
Cardiac toxicity with capecitabine, vinorelbine and trastuzumab therapy: case report and review of fluoropyrimidine-related cardiotoxicity. Oncology, 2009, Volume: 76, Issue:5 Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera	2009
Late myocardial ischemia with ST-segment elevation after negative dobutamine stress echocardiography in a patient with normal coronary arteries. Journal of cardiovascular medicine (Hagerstown, Md.), 2009, Volume: 10, Issue:4 Topics: Administration, Sublingual; Aged, 80 and over; Angina Pectoris; Biomarkers; Coronary Angiography; Co	2009
Anesthetic management for severe aortic regurgitation in an infant repaired by Ross procedure. Journal of anesthesia, 2009, Volume: 23, Issue:2 Topics: Anesthesia; Aortic Valve; Aortic Valve Insufficiency; Cardiac Surgical Procedures; Cardiopulmonary B	2009
ALERT: Revatio is another brand name for sildenafil. Dynamics (Pembroke, Ont.), 2009,Spring, Volume: 20, Issue:2 Topics: Canada; Contraindications; Drug Interactions; Female; Humans; Hypertension, Pulmonary; Medication Er	2009
Angina. A primer on what can happen if a heart is in need of blood. Harvard health letter, 2009, Volume: 34, Issue:9 Topics: Angina Pectoris; Humans; Myocardial Ischemia; Myocardium; Nitroglycerin; Vasodilator Agents	2009
[The influence of nitroglycerin on sinus node chronotropic response in ischemic heart disease]. Kardiologia polska, 2004, Volume: 61 Suppl 2 Topics: Adult; Aged; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Sick	2004
Cardiac shock wave therapy reduces angina and improves myocardial function in patients with refractory coronary artery disease. Clinical cardiology, 2010, Volume: 33, Issue:11 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; China; Coronary Artery Disease; Coronary Circ	2010
Myocardial ischaemia in patients with coronary endothelial dysfunction: insights from body surface ECG mapping and implications for invasive evaluation of chronic chest pain. European heart journal, 2011, Volume: 32, Issue:22 Topics: Acetylcholine; Adult; Blood Flow Velocity; Chest Pain; Chronic Pain; Coronary Circulation; Electroca	2011
Baroreflex mechanisms and response to exercise in patients with heart disease. Clinical physiology and functional imaging, 2012, Volume: 32, Issue:4 Topics: Adrenergic alpha-Agonists; Aged; Baroreflex; Blood Pressure; Chi-Square Distribution; Exercise; Exer	2012
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:6 Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co	2012
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:6 Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co	2012
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:6 Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co	2012
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study. JACC. Cardiovascular interventions, 2012, Volume: 5, Issue:6 Topics: Acetylcholine; Adenosine; Adult; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Co	2012
Guideline stresses medical therapy for treating stable ischemic heart disease. JAMA, 2013, Jan-16, Volume: 309, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Decision Making; Diet; Evidence-Based Practice	2013
Cardiac necrosis markers associated with low nitric oxide levels in the plasma of rabbits after treatment with vasopressin: protective effects of nitroglycerin administration. Pharmacological research, 2002, Volume: 45, Issue:6 Topics: Animals; Biomarkers; Creatine Kinase; Creatine Kinase, MB Form; Electrocardiography; Fibrinogen; Iso	2002
Usefulness of the response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency department. The American journal of cardiology, 2002, Dec-01, Volume: 90, Issue:11 Topics: Administration, Sublingual; Aged; Chest Pain; Electrocardiography; Emergency Service, Hospital; Fema	2002
[Mitral insufficiency related to a spasm of the left anterior descending artery. A case report]. Archives des maladies du coeur et des vaisseaux, 2003, Volume: 96, Issue:1 Topics: Aged; Arteriosclerosis; Calcium Channel Blockers; Cardiac Catheterization; Coronary Vasospasm; Echoc	2003
[Questionnaire for patients with ischaemic cardiopathy on their reaction to various alarm symptoms]. Atencion primaria, 2003, Mar-15, Volume: 31, Issue:4 Topics: Aged; Angina Pectoris; Chest Pain; Emergencies; Emergency Service, Hospital; Female; Humans; Male; M	2003
Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart. Journal of the American College of Cardiology, 2003, May-21, Volume: 41, Issue:10 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Dobutamine; Electrocar	2003
Absolute quantitation of myocardial blood flow after nitroglycerin and ischemic cardiomyopathy with a low ejection fraction. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003, Volume: 44, Issue:11 Topics: Coronary Circulation; Humans; Myocardial Ischemia; Nitroglycerin; Stroke Volume; Vascular Resistance	2003
Dobutamine-induced ST-segment elevation associated with a biphasic response of wall motion in patients with a recent myocardial infarction is caused by myocardial ischaemia and is abolished by revascularization of the infarct-related artery. Acta cardiologica, 2003, Volume: 58, Issue:6 Topics: Adrenergic beta-Agonists; Aged; Angioplasty, Balloon, Coronary; Biomarkers; Coronary Angiography; Co	2003
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation, 2004, Feb-17, Volume: 109, Issue:6 Topics: Acetylcholine; Adenosine; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Co	2004
Acute mediastinitis: a severe complication of transdermal therapy in a patient with ischaemic heart disease. A case report. Le infezioni in medicina, 2003, Volume: 11, Issue:2 Topics: Acute Disease; Administration, Cutaneous; Cellulitis; Humans; Male; Mediastinitis; Middle Aged; Myoc	2003
Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy. The American journal of cardiology, 2004, Aug-15, Volume: 94, Issue:4 Topics: Acetylcholine; Aged; Blood Flow Velocity; Cardiac Volume; Coronary Angiography; Coronary Artery Dise	2004
[Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2004, Volume: 16, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Female; Infusion Pumps; Male; Myocardial Ischemia; Nitroglyce	2004
Antiplatelet therapy in non-ST-segment elevation acute coronary syndromes. JAMA, 2004, Oct-20, Volume: 292, Issue:15 Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery B	2004
[An experience of the use of stenting for recurrence of myocardial ischemia after coronary artery bypass grafting]. Kardiologiia, 2005, Volume: 45, Issue:1 Topics: Coronary Angiography; Coronary Artery Bypass; Coronary Restenosis; Exercise Test; Female; Humans; Hy	2005
Differential release of cardiac enzymes after percutaneous coronary intervention. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2005, Volume: 65, Issue:1 Topics: Angioplasty, Balloon, Coronary; Biomarkers; Calcium Channel Blockers; Coronary Vessels; Creatine Kin	2005
[Effects of therapy with various groups of antianginal agents on life quality of the elderly with coronary heart disease and comorbid depression]. Klinicheskaia meditsina, 2005, Volume: 83, Issue:7 Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Atenolol; Calcium Channel Blockers; Depression; Dise	2005
Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia. Apoptosis : an international journal on programmed cell death, 2005, Volume: 10, Issue:6 Topics: Adaptation, Physiological; Animals; Apoptosis; Blood Pressure; Caspase 3; Creatine Kinase; Dietary S	2005
Peripheral vascular endothelial function correlates with exercise capacity in women. Clinical cardiology, 2005, Volume: 28, Issue:9 Topics: Adult; Age Factors; Aged; Body Mass Index; Brachial Artery; Endothelium, Vascular; Exercise Test; Ex	2005
[Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina]. Terapevticheskii arkhiv, 2005, Volume: 77, Issue:10 Topics: Adult; Aged; Angina Pectoris; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Exercise	2005
Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning. Basic research in cardiology, 2006, Volume: 101, Issue:4 Topics: Animals; Blood Pressure; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated P	2006
Glutathione reverses peroxynitrite-mediated deleterious effects of nitroglycerin on ischemic rat hearts. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:3 Topics: Animals; Apoptosis; Glutathione; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reper	2006
Effects of nitroglycerin on erythrocyte rheology and oxygen unloading: novel role of S-nitrosohemoglobin in relieving myocardial ischemia. Circulation, 2006, May-30, Volume: 113, Issue:21 Topics: Animals; Blood Flow Velocity; Blood Gas Monitoring, Transcutaneous; Blood Viscosity; Dogs; Erythrocy	2006
Assessment of viable myocardium by nitrate augmented 99mTc MIBI myocardial perfusion imaging. JPMA. The Journal of the Pakistan Medical Association, 2007, Volume: 57, Issue:2 Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Radiopharmaceuti	2007
Nitroglycerin induces late preconditioning against arrhythmias but not stunning in conscious sheep. Scandinavian cardiovascular journal : SCJ, 2007, Volume: 41, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Consciousness; Coronary Circulation; Disease	2007
Phytoestrogens and coronary microvascular function in women with suspected myocardial ischemia: a report from the Women's Ischemia Syndrome Evaluation (WISE) Study. Journal of women's health (2002), 2007, Volume: 16, Issue:4 Topics: Acetylcholine; Adenosine; Adult; Aged; Blood Flow Velocity; Coronary Angiography; Coronary Artery Di	2007
[Scintigaraphic assessment of viability of the ischemic myocardium while carrying out nitroglycerine-mediated and orthostatic tests]. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2006, Volume: 12, Issue:3 Topics: Adult; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Myocardial Ischemia; Nitroglycer	2006
Evidence of pathological coronary flow patterns in patients with isolated coronary artery aneurysms. Coronary artery disease, 2008, Volume: 19, Issue:4 Topics: Aged; Angina Pectoris; Blood Flow Velocity; Cohort Studies; Coronary Aneurysm; Coronary Angiography;	2008
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:3 Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Crom	1994
Low-dose i.v. acetylcholine acts as a "preconditioning-mimetic" in the canine model. Journal of cardiac surgery, 1995, Volume: 10, Issue:4 Suppl Topics: Acetylcholine; Animals; Disease Models, Animal; Dogs; Heart; Humans; Infusions, Intravenous; Myocard	1995
Nitroglycerin-induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin. British journal of pharmacology, 1995, Volume: 115, Issue:7 Topics: Animals; Coronary Vessels; Drug Tolerance; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Ni	1995
Transmural myocardial ischaemia during dobutamine stress echocardiography. Lancet (London, England), 1995, Aug-05, Volume: 346, Issue:8971 Topics: Aged; Angina Pectoris; Atropine; Chest Pain; Dobutamine; Echocardiography; Female; Humans; Myocardia	1995
[Effects of nitroglycerin on myocardial contraction in patients with ischemic heart disease]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:6 Topics: Adult; Coronary Artery Bypass; Electrocardiography; Heart; Hemodynamics; Humans; Middle Aged; Myocar	1995
Can nitroglycerin convert effort-induced angina in men into silent myocardial ischemia? The American journal of cardiology, 1995, Aug-15, Volume: 76, Issue:5 Topics: Administration, Sublingual; Aged; Angina Pectoris; Blood Pressure; Data Interpretation, Statistical;	1995
Myocardial ischemia induced by topical use of 5-fluorouracil. International journal of cardiology, 1995, Volume: 49, Issue:3 Topics: Administration, Topical; Aged; Aged, 80 and over; Angina Pectoris; Carcinoma, Basal Cell; Drug Thera	1995
[Fast-acting nitroglycerin derivatives]. Soins; la revue de reference infirmiere, 1994, Issue:589 Topics: Humans; Myocardial Ischemia; Nitroglycerin; Time Factors	1994
Current status of silent myocardial ischemia. The Canadian journal of cardiology, 1995, Volume: 11, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; El	1995
Silent myocardial ischemia during PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1995, Volume: 36, Issue:6 Topics: Aged; Heart; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Tomography, Emission-Com	1995
Coronary vasoconstriction mediated by endothelin-1 in neonates. Reversal by nitroglycerin. The Journal of thoracic and cardiovascular surgery, 1995, Volume: 109, Issue:1 Topics: Adult; Animals; Cardiopulmonary Bypass; Child, Preschool; Coronary Vessels; Endothelins; Female; Hea	1995
[The functional dynamics of capillary blood flow in patients with IHD combined with diabetes mellitus]. Terapevticheskii arkhiv, 1994, Volume: 66, Issue:12 Topics: Angina, Unstable; Angiography, Digital Subtraction; Capillaries; Conjunctiva; Diabetes Mellitus, Typ	1994
Comparative examination of Adalat and Cordaflex in anti-ischaemic therapy. Therapia Hungarica (English edition), 1993, Volume: 41, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Electrocardiog	1993
Variable responses of highly stenotic coronary arteries and collateral circulation to intracoronary injection of nitroglycerin in patients with chronic effort angina. Coronary artery disease, 1994, Volume: 5, Issue:6 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cardiac Pacing, Artificial; Chronic Disease; Collatera	1994
Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin. British journal of pharmacology, 1994, Volume: 112, Issue:4 Topics: Animals; Blood Pressure; Cardiac Pacing, Artificial; Cyclic GMP; Drug Tolerance; Male; Myocardial Is	1994
[Endothelial damage and repair in myocardial ischemia and reperfusion]. Japanese circulation journal, 1993, Volume: 57 Suppl 4 Topics: Acetylcholine; Animals; Cats; Coronary Vessels; Endothelium, Vascular; Myocardial Ischemia; Myocardi	1993
Prophylactic nitroglycerin and perioperative ischemia: power analysis and a meta-analysis. Anesthesia and analgesia, 1994, Volume: 79, Issue:5 Topics: Humans; Meta-Analysis as Topic; Myocardial Ischemia; Nitroglycerin	1994
U-46619-induced ischaemic electrocardiographic changes in rats: preventive effects of prostacyclin and nitroglycerin. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:7 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Analysis of Variance; Animals; B	1994
Effects of spinal cord stimulation on myocardial ischaemia during daily life in patients with severe coronary artery disease. A prospective ambulatory electrocardiographic study. British heart journal, 1994, Volume: 71, Issue:5 Topics: Aged; Angina Pectoris; Chronic Disease; Electric Stimulation Therapy; Electrocardiography, Ambulator	1994
Attenuation of coronary flow reserve and myocardial function after temporary subtotal coronary artery occlusion and increased myocardial oxygen demand in dogs. Journal of the American College of Cardiology, 1994, Volume: 24, Issue:3 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Cardiac	1994
The short-term effect of intravenous nitroglycerin on haematocrit; an additional benefit in patients with myocardial ischaemia? European heart journal, 1994, Volume: 15, Issue:1 Topics: Aged; Blood Proteins; Blood Viscosity; Female; Hematocrit; Hemodilution; Hemoglobins; Humans; Infusi	1994
Paradoxic, glycerol-trinitrate induced hypertension. Chest, 1994, Volume: 105, Issue:5 Topics: Aged; Blood Pressure; Female; Humans; Hypertension; Infusions, Intravenous; Myocardial Ischemia; Nit	1994
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property. Clinical and experimental pharmacology & physiology, 1993, Volume: 20, Issue:9 Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating	1993
Impairment of the arterial baroreflex during symptomatic and silent myocardial ischemia in humans. Journal of the American College of Cardiology, 1993, Volume: 22, Issue:7 Topics: Baroreflex; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Myoc	1993
Safety of prehospital nitroglycerin. Annals of emergency medicine, 1994, Volume: 23, Issue:1 Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Bradycardia; Emergencies; Emergency Medi	1994
Attenuation of baroreflex changes in cardiac sympathetic efferent activities during acute myocardial ischemia. American heart journal, 1993, Volume: 126, Issue:2 Topics: Animals; Blood Pressure; Dogs; Efferent Pathways; Female; Heart; Male; Myocardial Ischemia; Nitrogly	1993
In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. Cancer research, 1993, Jul-01, Volume: 53, Issue:13 Topics: Animals; Antineoplastic Agents; Calcium Channels; Drug Interactions; Endothelium, Vascular; Fluorour	1993
Effect of FK409, a novel nitric oxide donor, on acute experimental myocardial ischemia. Japanese journal of pharmacology, 1993, Volume: 62, Issue:3 Topics: Animals; Coronary Circulation; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Electri	1993
Contractile and vascular consequences of blood versus crystalloid cardioplegia in the isolated blood-perfused rat heart. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1993, Volume: 7, Issue:3 Topics: Acetylcholine; Adenosine Triphosphate; Analysis of Variance; Animals; Blood Pressure; Cardioplegic S	1993
Perioperative myocardial ischemia in carotid endarterectomy under cervical plexus block and prophylactic nitroglycerin infusion. Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:3 Topics: Aged; Aged, 80 and over; Arterial Occlusive Diseases; Blood Pressure; Carotid Arteries; Carotid Arte	1993
Left main coronary artery spasm. International journal of cardiology, 1995, Volume: 51, Issue:2 Topics: Amlodipine; Angina Pectoris; Coronary Vasospasm; Diagnosis, Differential; Follow-Up Studies; Humans;	1995
Potential problems with intermittent nitrate therapy. The Canadian journal of cardiology, 1996, Volume: 12 Suppl C Topics: Angina Pectoris; Dose-Response Relationship, Drug; Drug Tolerance; Exercise; Humans; Myocardial Isch	1996
Nitrate tolerance--problems both new and old. The Canadian journal of cardiology, 1996, Volume: 12 Suppl C Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris; Delayed-Action Preparations; Drug	1996
Prophylactic nitroglycerine and incidence of myocardial ischemia in high risk patients following major surgery. Anaesthesia, 1996, Volume: 51, Issue:4 Topics: Humans; Myocardial Ischemia; Nitroglycerin; Postoperative Complications; Retrospective Studies; Vaso	1996
[Effects of nitroglycerin and nifedipine on stunned myocardium due to brief repeated ischemias]. Revista espanola de cardiologia, 1996, Volume: 49, Issue:5 Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Data Interpretation, Statistical; Dogs; Ele	1996
[Detection of stress-induced myocardial ischemia in isolated coronary ectasia and aneurysm (dilatative coronaropathy)]. Zeitschrift fur Kardiologie, 1996, Volume: 85, Issue:6 Topics: Adult; Aged; Coronary Aneurysm; Coronary Angiography; Diagnosis, Differential; Electrocardiography;	1996
Haemodynamic changes during laparoscopic cholecystectomy in the high-risk patient. Endoscopic surgery and allied technologies, 1995, Volume: 3, Issue:4 Topics: Aged; Aged, 80 and over; Anesthesia, General; Blood Pressure; Carbon Dioxide; Cardiac Output; Cathet	1995
[Symptomatic myocardial bridges. Apropos of 6 cases]. Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89, Issue:7 Topics: Adult; Coronary Angiography; Coronary Artery Bypass; Coronary Vessel Anomalies; Exercise Test; Femal	1996
The use of GTN to improve the detection of ischaemic myocardium using 99Tcm-tetrofosmin. Nuclear medicine communications, 1996, Volume: 17, Issue:8 Topics: Administration, Sublingual; Adult; Aged; Coronary Angiography; Coronary Disease; Exercise Test; Fema	1996
Effects of nitroglycerin infusion on segmental wall motion abnormalities after anesthetic induction. Journal of cardiothoracic and vascular anesthesia, 1996, Volume: 10, Issue:6 Topics: Aged; Anesthesia; Coronary Artery Bypass; Echocardiography, Transesophageal; Female; Humans; Male; M	1996
Sympathetic alternans. Evidence for arterial baroreflex control of muscle sympathetic nerve activity in congestive heart failure. Circulation, 1997, Jan-21, Volume: 95, Issue:2 Topics: Adult; Arteries; Baroreflex; Blood Pressure; Cardiomyopathy, Dilated; Diastole; Heart Failure; Human	1997
[Pharmacotherapy of silent myocardial ischemia in patients on hemodialysis]. Vnitrni lekarstvi, 1996, Volume: 42, Issue:12 Topics: Adrenergic beta-Agonists; Adult; Aged; Calcium Channel Blockers; Female; Humans; Kidney Failure, Chr	1996
The relationship between circadian rhythm and ischemic heart disease, and its implication for nitrate patch utilization. The Nurse practitioner, 1997, Volume: 22, Issue:3 Topics: Administration, Cutaneous; Chronotherapy; Humans; Myocardial Ischemia; Nitroglycerin; Vasodilator Ag	1997
[Cardicap treatment of ischemic heart disease in aged patients]. Klinicheskaia meditsina, 1997, Volume: 75, Issue:1 Topics: Administration, Oral; Echocardiography; Electrocardiography, Ambulatory; Exercise Test; Female; Foll	1997
The nitric oxide donor ITF 1129 augments subendocardial blood flow during exercise-induced myocardial ischemia. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:3 Topics: Analysis of Variance; Animals; Dogs; Hemodynamics; Myocardial Contraction; Myocardial Ischemia; Nitr	1997
Lipoprotein(a) selectively impairs receptor-mediated endothelial vasodilator function of the human coronary circulation. Journal of the American College of Cardiology, 1997, Volume: 30, Issue:4 Topics: Acetylcholine; Aged; Case-Control Studies; Coronary Circulation; Coronary Disease; Dose-Response Rel	1997
Nitroglycerin echocardiography and dobutamine. Angiology, 1997, Volume: 48, Issue:10 Topics: Arrhythmias, Cardiac; Cardiotonic Agents; Collateral Circulation; Coronary Circulation; Coronary Ves	1997
Targeting of dobutamine to ischemic myocardium without systemic effects by selective suction and pressure-regulated retroinfusion. Cardiovascular research, 1997, Volume: 35, Issue:2 Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Dobutamine; Drug Administration Schedul	1997
Relative susceptibility of endothelium and myocardial cells to ischaemia-reperfusion injury. Acta physiologica Scandinavica, 1997, Volume: 161, Issue:1 Topics: Animals; Aorta; Coronary Vessels; Endothelium, Vascular; Hypothermia, Induced; Male; Muscle Fibers,	1997
Nitroglycerin-induced hypoxemia does not produce myocardial ischemia. Journal of cardiothoracic and vascular anesthesia, 1997, Volume: 11, Issue:7 Topics: Adult; Aged; Female; Humans; Hypoxia; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Vasodil	1997
Early postexercise thallium-201 reinjection after sublingual nitroglycerin augmentation: effects on detection of myocardial ischemia and/or viability. Clinical cardiology, 1998, Volume: 21, Issue:6 Topics: Adult; Aged; Confounding Factors, Epidemiologic; Exercise Test; Female; Heart; Humans; Male; Middle	1998
Is nitroglycerin detrimental in patients with coronary artery ectasia? A case report. Texas Heart Institute journal, 1998, Volume: 25, Issue:2 Topics: Coronary Angiography; Coronary Vessel Anomalies; Electrocardiography; Follow-Up Studies; Humans; Inf	1998
Minimally invasive direct coronary artery bypass: anesthetic, monitoring, and pain control considerations. Journal of cardiothoracic and vascular anesthesia, 1998, Volume: 12, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia, General	1998
Sildenafil in the treatment of erectile dysfunction. The New England journal of medicine, 1998, Sep-03, Volume: 339, Issue:10 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aged; Coitus; Contraindications; Drug Interactions; Erectile Dy	1998
Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: a comparison with cromakalim and nitroglycerin. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:1 Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cardiac Output, Low; Cromakalim; Dogs; Embolizati	1999
Tl-201 myocardial perfusion SPECT: role of nitrate-augmented redistribution. Clinical nuclear medicine, 1999, Volume: 24, Issue:1 Topics: Coronary Circulation; Coronary Disease; Coronary Vessels; Exercise Test; Female; Follow-Up Studies;	1999
Autonomic neural control during acute myocardial ischemia after phenylephrine infusion and subsequent nitroglycerin-induced hypotension and bradycardia. Giornale italiano di cardiologia, 1999, Volume: 29, Issue:1 Topics: Angina Pectoris; Autonomic Nervous System; Baroreflex; Blood Pressure; Heart Rate; Humans; Male; Mid	1999
ST-T alternans and myocardial ischemia. Angiology, 1999, Volume: 50, Issue:3 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Chi-Square Distribution; Coron	1999
The routine use of sublingual GTN with resting 99Tcm-tetrofosmin myocardial perfusion imaging. Nuclear medicine communications, 1998, Volume: 19, Issue:10 Topics: Administration, Sublingual; Adult; Aged; Coronary Disease; Coronary Vessels; Exercise Test; Female;	1998
Anesthetic management of high-risk cardiac patients undergoing noncardiac surgery under the support of intraaortic balloon pump. Journal of clinical anesthesia, 1999, Volume: 11, Issue:4 Topics: Aged; Anesthesia, General; Angina Pectoris; Carcinoma; Colectomy; Colon, Sigmoid; Coronary Disease;	1999
Nonischemic ST-segment elevation induced by negative inotropic agents. Japanese circulation journal, 1999, Volume: 63, Issue:8 Topics: Adenosine; Animals; Depression, Chemical; Dogs; Dyskinesia, Drug-Induced; Electrocardiography; Femal	1999
Nitric oxide donors attenuate myocardial stunning in conscious rabbits. The American journal of physiology, 1999, Volume: 277, Issue:6 Topics: Analysis of Variance; Animals; Blood Pressure; Consciousness; Heart; Heart Rate; Hemodynamics; Infus	1999
Direct myocardial anti-ischaemic effect of GTN in both nitrate-tolerant and nontolerant rats: a cyclic GMP-independent activation of KATP. British journal of pharmacology, 1999, Volume: 128, Issue:7 Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Cyclic AMP; Glyburide; Heart; Hypoglycemic Ag	1999
Acute myocardial ischemia after administration of ondansetron hydrochloride. Anesthesiology, 2000, Volume: 92, Issue:3 Topics: Acute Disease; Antiemetics; Electrocardiography; Female; Humans; Injections, Intravenous; Middle Age	2000
[Cardiac tomography with 99mTc-tetrofosmin after nitrate administration in patients with ischemic cardiopathy and left ventricular dysfunction]. La Radiologia medica, 2000, Volume: 99, Issue:4 Topics: Adult; Aged; Chronic Disease; Heart; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; N	2000
Nitroglycerin and delayed preconditioning in humans: yet another new mechanism for an old drug? Circulation, 2001, Jun-19, Volume: 103, Issue:24 Topics: Angioplasty, Balloon, Coronary; Animals; Calcium Channel Blockers; Electrocardiography; Endpoint Det	2001
Relationship between vascular dysfunction in peripheral arteries and ischemic episodes during daily life in patients with ischemic heart disease and hypercholesterolemia. American heart journal, 2002, Volume: 144, Issue:1 Topics: Aged; Arrhythmias, Cardiac; Brachial Artery; Electrocardiography; Electrocardiography, Ambulatory; E	2002
[The effects of nitroglycerin on refractory congestive heart failure by intravenous infusion]. Zhonghua xin xue guan bing za zhi, 1992, Volume: 20, Issue:3 Topics: Adult; Aged; Cardiomyopathy, Dilated; Female; Heart Failure; Hemodynamics; Humans; Infusions, Intrav	1992
Fatal torsade de pointes occurring in a patient receiving intravenous vasopressin and nitroglycerin. Journal of clinical gastroenterology, 1992, Volume: 15, Issue:2 Topics: Aged; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Infusions, Intravenous; M	1992
[The multiple coronary spasm as the cause of acute ischemic events. A case report of a simultaneous spasm of the anterior descending and the circumflex during coronary angiography]. Giornale italiano di cardiologia, 1992, Volume: 22, Issue:7 Topics: Acute Disease; Coronary Angiography; Coronary Vasospasm; Humans; Male; Middle Aged; Myocardial Infar	1992

nitroglycerin and Myocardial Ischemia

Research Excerpts

Research

Studies (198)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Endothelial Dysfunction (FMD)

Endothelial Dysfunction (FMD)

Inducible Myocardial Ischemia

Inducible Myocardial Ischemia

Physical Functional Disability - Functional Capacity (Exercise Induced ST Segment Depression)

Physical Functional Disability - Functional Capacity (Metabolism Equivalents)

Physical Functional Disability - Functional Capacity (Metabolism Equivalents)

Physical Functional Disability - Functional Capacity (METs)

Physical Functional Disability - Functional Capacity (METs)

Physical Functional Disability - Functional Capacity (Stress Induced ST Segment Depression)

Quality of Life - Health Survey

Quality of Life - Health Survey

Quality of Life - Menopause Symptoms

Quality of Life - Menopause Symptoms

Reviews

Trials

Other Studies