nitroglycerin has been researched along with Muscle Relaxation in 278 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 9.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular ." | 7.69 | Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. ( Freeman, BA; Griendling, KK; Harrison, DG; Kurz, S; Münzel, T; Rajagopalan, S; Tarpey, M, 1996) |
| "To evaluate the potency of vasodilatory drugs in hypoxia, we studied the effects of nitroglycerin (NTG), prostaglandin E1 (PGE1), and hydralazine on porcine coronary artery constricted with endothelin-1 (ET-1) in both oxygenated and hypoxic conditions." | 7.69 | Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries. ( Fujihara, H; Fujiwara, N; Fukuda, S; Sakuma, K; Shimoji, K; Tanaka, T; Toriumi, T; Tsukui, A, 1994) |
| " The relaxant actions of nitroglycerin (previously considered to be an endothelium-independent relaxing agent) and acetylcholine (an endothelium-dependent relaxing agent) were compared on 4 vascular preparations (dorsal pedal artery, saphenous vein, left anterior descending coronary artery and circumflex coronary artery) from dogs with and without pacing-induced congestive heart failure (CHF)." | 7.68 | Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure. ( Armstrong, PW; Forster, C; Main, JS, 1990) |
| "In the rabbit subarachnoid hemorrhage (SAH) model, the sensitivity of spastic basilar arteries to nitric oxide (NO) was enhanced whereas the endothelial function to release/produce NO became impaired, as described previously." | 5.31 | Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. ( Azuma, H; Hirakawa, K; Isotani, E; Ito, Y; Mizuno, Y, 2000) |
| "Halothane has been reported to inhibit endothelium-dependent relaxation in a variety of vessels." | 5.29 | Effects of halothane on EDRF/cGMP-mediated vascular smooth muscle relaxations. ( Bina, S; Freas, W; Hart, JL; Jing, M; Muldoon, SM; Van Dyke, RA, 1993) |
| "Continuous nitroglycerin (NTG) administration causes pharmacologic tolerance in humans and animals, whereas intermittent dosing is capable of avoiding or reducing tolerance development." | 5.29 | Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels. ( Bauer, JA; Fung, HL; Gopalakrishnan, M; Kwon, YW; Triggle, DJ; Zheng, W, 1993) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 5.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "Glyceryl trinitrate, isosorbide dinitrate, and isosorbide-5-mononitrate are organic nitrate esters commonly used in the treatment of angina pectoris, myocardial infarction, and congestive heart failure." | 4.79 | Mechanisms of action of nitrates. ( Ahlner, J; Torfgård, KE, 1994) |
| "To report the use of regional anesthesia and iv nitroglycerin to provide anesthesia and uterine relaxation for three Cesarean deliveries (CD) involving ex utero intrapartum treatment (EXIT) of potentially life-threatening airway obstruction in the newborn." | 3.74 | Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure. ( George, RB; Habib, AS; Melnick, AH; Rose, EC, 2007) |
| "To evaluate the potency of vasodilatory drugs in hypoxia, we studied the effects of nitroglycerin (NTG), prostaglandin E1 (PGE1), and hydralazine on porcine coronary artery constricted with endothelin-1 (ET-1) in both oxygenated and hypoxic conditions." | 3.69 | Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries. ( Fujihara, H; Fujiwara, N; Fukuda, S; Sakuma, K; Shimoji, K; Tanaka, T; Toriumi, T; Tsukui, A, 1994) |
| "Carbon monoxide (CO), a vasodilator, has been implicated as an activator of soluble guanylyl cyclase (sGC) to effect smooth muscle relaxation; however, this idea has not received universal support." | 3.69 | The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate. ( Brien, JF; Hussain, AS; Marks, GS; Nakatsu, K, 1997) |
| "The purpose of this study was to examine and compare pulmonary vascular smooth muscle relaxation by clinically used agents as related to cGMP mediation (sodium nitroprusside, nitroglycerin) and cAMP mediation (isoproterenol, prostaglandin E1 (PGE1), and amrinone) in isolated rat pulmonary arterial rings." | 3.69 | Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms. ( Banerjee, A; Fullerton, DA; Hahn, AR; Harken, AH, 1994) |
| "We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular ." | 3.69 | Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. ( Freeman, BA; Griendling, KK; Harrison, DG; Kurz, S; Münzel, T; Rajagopalan, S; Tarpey, M, 1996) |
| "We have examined the interaction of zaprinast, a selective inhibitor of cGMP phosphodiesterase, with guanylate cyclase activators on vascular smooth muscle relaxation in vitro and in vivo." | 3.68 | In vitro and in vivo interactions of nitrovasodilators and zaprinast, a cGMP-selective phosphodiesterase inhibitor. ( Lappe, RW; Merkel, LA; Perrone, MH; Rivera, LM, 1992) |
| " The relaxant actions of nitroglycerin (previously considered to be an endothelium-independent relaxing agent) and acetylcholine (an endothelium-dependent relaxing agent) were compared on 4 vascular preparations (dorsal pedal artery, saphenous vein, left anterior descending coronary artery and circumflex coronary artery) from dogs with and without pacing-induced congestive heart failure (CHF)." | 3.68 | Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure. ( Armstrong, PW; Forster, C; Main, JS, 1990) |
| " Heterologous desensitization could not be demonstrated to the vasoactive peptides angiotensin II or vasopressin, nor to nitroglycerin which has previously been shown to exhibit heterologous desensitization with other nitrovasodilators and shares some common elements in the pathway to vascular smooth muscle relaxation with ANF." | 3.68 | Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings. ( McWilliam, TM; Rankin, AJ; Swift, FV; Triggle, CR, 1990) |
| "Smooth muscle relaxation is well tolerated, can be administered on an outpatient basis, does not cause any lesion of the continence organ, and subsequently, does not lead to any permanent latent or apparent fecal incontinence." | 2.44 | Nonsurgical approaches for the treatment of anal fissures. ( Chopra, S; Dhawan, S, 2007) |
| " Incubation with CGRP8-37 (10(-6) M) specifically during the 90-minute desensitization period with nitroglycerin resulted in even greater impairment in the response to nitroglycerin in tolerant rings, even though the calcitonin gene-related peptide antagonist had been washed out before completion of the nitroglycerin dose-response curve." | 1.33 | Nitroglycerin-induced release of calcitonin gene-related peptide from sensory nerves attenuates the development of nitrate tolerance. ( Ghatta, S; O'Rourke, ST, 2006) |
| "In the rabbit subarachnoid hemorrhage (SAH) model, the sensitivity of spastic basilar arteries to nitric oxide (NO) was enhanced whereas the endothelial function to release/produce NO became impaired, as described previously." | 1.31 | Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin. ( Azuma, H; Hirakawa, K; Isotani, E; Ito, Y; Mizuno, Y, 2000) |
| " The dose-response curve of CpCr(NO)2Cl was displaced to the right by hemoglobin, as well as methylene blue, showing involvement of the NO/cGMP pathway." | 1.31 | Vasodilator effects of organotransition-metal nitrosyl complexes, novel nitric oxide donors. ( Legzdins, P; Pang, CC; Poon, JS; Wang, YX, 2000) |
| " This dose of ZD2574 markedly blunted the pressor response to ET-1, indicating effective blockade of ET(A) receptors, and also abolished the initial transient depressor response to ET-1, indicating that blockade of endothelial ET(B) receptors also occurred using this dosage regimen for ZD2574." | 1.31 | Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat. ( Adams, MA; Bennett, BM; Fraser, AB; Ratz, JD; Rees-Milton, KJ, 2000) |
| " Conclusively, nipradilol, beta-blocker with nitric oxide-releasing action, in contrast to the other beta-blockers and nitric oxide donors, showed a successful anti-atherosclerotic effect through the restoration of nitric oxide bioavailability and possible interaction with oxygen radicals." | 1.31 | Anti-atherosclerotic effect of beta-blocker with nitric oxide-releasing action on the severe atherosclerosis. ( Hayashi, T; Iguchi, A; Kano, H; Matsui-Hirai, H; Sumi, D; Thakur, NK; Tsunekawa, T, 2002) |
| " Vitamin C inhibited relaxation to GTN but potentiated relaxations to NP and SNAP, causing a parallel shift to a lower concentration range of the log dose-response curve by approximately one log unit at the highest dose." | 1.31 | Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors. ( Chowienczyk, PJ; de Saram, K; Khokher, S; McNeill, KL; Ritter, JM, 2002) |
| "Halothane has been shown to inhibit the action of NO on blood vessels." | 1.30 | Halothane attenuates nitric oxide relaxation of rat aortas by competition for the nitric oxide receptor site on soluble guanylyl cyclase. ( Bina, S; Hart, JL; Jing, M; Ling, GS; Muldoon, SM, 1998) |
| "Nisoldipine was about 10 times more potent than was nifedipine (EC50, 6." | 1.29 | Synergistic effect of nisoldipine and nitroglycerin on human internal mammary artery. ( Buxton, BF; Johnston, CI; Liu, JJ, 1994) |
| " Vessels were exposed to thiacetarsamide and dose-response relationships were applied to methacholine and nitroglycerin." | 1.29 | Thiacetarsamide depresses relaxation of canine pulmonary artery in vitro. ( Kaiser, L; Maksimowich, DS; Williams, JF, 1996) |
| "5 microM) had no significant effect on relaxation dose-response curves (DRCs) to ACh, NTG or NO." | 1.29 | Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide. ( Khan, SA; Mathews, WR; Meisheri, KD, 1993) |
| "Continuous nitroglycerin (NTG) administration causes pharmacologic tolerance in humans and animals, whereas intermittent dosing is capable of avoiding or reducing tolerance development." | 1.29 | Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels. ( Bauer, JA; Fung, HL; Gopalakrishnan, M; Kwon, YW; Triggle, DJ; Zheng, W, 1993) |
| "3." | 1.29 | Differential vasodilator properties of KRN2391, cromakalim, nitroglycerin and nifedipine in rabbit isolated femoral artery and vein. ( Fukushima, H; Izawa, T; Kashiwabara, T; Ogawa, N, 1994) |
| "Nitroglycerin relaxation was not different; however, methacholine relaxation was significantly depressed in rings exposed to serum from heartworm-infected dogs when compared with that of controls." | 1.29 | Effect of serum from dogs infected with Dirofilaria immitis on endothelium-dependent relaxation of rat aorta in vitro. ( Kaiser, L; Lamb, VL; Williams, JF, 1993) |
| " Nitroglycerin pre-exposure (10 microM for 30 min) provoked a significant shift to the right of the dose-response curve to nitroglycerin in aortae isolated from rats of 8 weeks, 12 and 18 months." | 1.29 | Nitrate tolerance and aging in isolated rat aorta. ( Berkenboom, G; Brékine, D; Fontaine, J; Unger, P, 1993) |
| " None of the K+ channel blockers had an effect on the dose-response curve to NO, on the noradrenaline-induced contraction or on the relaxation to nitroglycerine (GTN)." | 1.29 | Prejunctional modulation of the nitrergic innervation of the canine ileocolonic junction via potassium channels. ( Boeckxstaens, GE; De Man, JG; De Winter, BY; Herman, AG; Pelckmans, PP; Van Maercke, YM, 1993) |
| "Halothane has been reported to inhibit endothelium-dependent relaxation in a variety of vessels." | 1.29 | Effects of halothane on EDRF/cGMP-mediated vascular smooth muscle relaxations. ( Bina, S; Freas, W; Hart, JL; Jing, M; Muldoon, SM; Van Dyke, RA, 1993) |
| "In severe preeclampsia absence of lactate-induced dilatation of placental vessels may contribute to the fetal complications associated with impaired blood flow and vasospasm." | 1.29 | Absence of relaxation to lactate in human placental vessels of pregnancies with severe preeclampsia. ( Fayngersh, RP; Figueroa, R; Jiang, H; Martinez, E; Omar, HA; Tejani, N; Wolin, MS, 1995) |
| "Pretreatment with iloprost did not significantly affect the concentration-response curve to any agent." | 1.28 | Relaxant effects on iloprost in canine cerebral artery. ( Cook, D; Doi, M; Kasuya, H; Weir, B; Zhang, H, 1992) |
| "4." | 1.28 | Impaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol. ( Dalipram, RA; Dusting, GJ; Sobey, CG; Woodman, OL, 1992) |
| "Pretreatment with phorone, a glutathione S-transferase substrate, depleted cellular glutathione and decreased nitrite production from GTN." | 1.28 | Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase. ( Burk, RF; Hill, KE; Hoover, RL; Hunt, RW; Jones, R, 1992) |
| "Pretreatment with methylene blue (10(-5) M) or nitroglycerin (3 x 10(-8) M) inhibited or potentiated, respectively, the relaxing action of melatonin." | 1.28 | The mode of vasorelaxing action of melatonin in rabbit aorta. ( Oe, H; Satake, N; Sawada, T; Shibata, S, 1991) |
| "Cromakalim is an effective spasmolytic against a number of vasoconstrictors in the dog coronary artery." | 1.28 | Spasmolytic effect of cromakalim in dog coronary artery in vitro. ( Angus, JA; Keily, SG; McPherson, GA, 1991) |
| " The ANF dose-response curves were similar in both tissues, however, relaxation was fast and transient in portal veins whereas it was sustained and of slow onset in aortas." | 1.28 | Different time course of atrial natriuretic factor-induced relaxation in rabbit aorta and portal vein. ( Castañeda-Hernández, G; De León, H; Hong, E, 1990) |
| " Following exposure for 24 h to a NTG patch (15 mg/24 h), NTG dose-response curves were not altered suggesting there was no development of tolerance to transdermal NTG." | 1.28 | Responsiveness of peripheral veins to transdermal and sublingual nitroglycerin in healthy male volunteers. ( Blaschke, TF; Hiremath, AN; Hoffman, BB, 1989) |
| " Dose-response curves were plotted from data obtained following exposure to histamine (10(-7)-10(-3)) and GTN (10(-9)-10(-7)) and compared to responses from age-matched untreated controls, diabetic and diabetic rats treated with insulin (2 U/day)." | 1.28 | Histamine relaxation of aortic rings from diabetic rats. ( Chang, KS; Tanz, RD; Weller, TS, 1989) |
| "Nitroglycerin was less effective than nitroprusside in elevating cyclic GMP levels, but was an effective relaxant in both tissues." | 1.27 | Lack of correlation between cyclic GMP elevation and relaxation of nonvascular smooth muscle by nitroglycerin, nitroprusside, hydroxylamine and sodium azide. ( Diamond, J, 1983) |
| "Nitroglycerin was a more potent antagonist (10-10,000 fold) of contractions produced by norepinephrine in the large coronary artery than in the other three vascular beds." | 1.27 | Comparative relaxant effects of nitroglycerin in isolated rings from various canine vascular beds. ( Gharaibeh, MN; Gross, GJ, 1984) |
| " Reasonably good temporal and dose-response correlations between cyclic GMP elevation and relaxation were obtained with acetylcholine." | 1.27 | Possible role for cyclic GMP in endothelium-dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin. ( Chu, EB; Diamond, J, 1983) |
| "Methylene blue pretreatment produced approximately 5-fold shifts to the right of both nitroglycerin and nitroprusside relaxation curves." | 1.27 | Nitroglycerin tolerance and cyclic GMP generation in the longitudinal smooth muscle of the guinea-pig ileum. ( Burkman, AM; Fertel, RH; Keith, RA; Sokoloski, TD, 1983) |
| " Two nitroglycerin dose-response curves were performed (n = 18)--one before (1st dose-response curve, from 10(-9) to 1." | 1.27 | N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings. ( Abdollah, A; Armstrong, PW; Moffat, JA, 1987) |
| " Isolated bovine pulmonary arteries and veins were contracted submaximally and cumulative dose-response relationships to glyceryl trinitrate were obtained; the vein was approximately 10 times more sensitive than the artery to glyceryl trinitrate induced relaxation." | 1.27 | A comparative study of glyceryl trinitrate biotransformation and glyceryl trinitrate induced relaxation in bovine pulmonary artery and vein. ( Brien, JF; Kawamoto, JH; Marks, GS; Nakatsu, K, 1987) |
| "Papaverine was shown to be the substance able to cause the biggest relaxation effect." | 1.27 | Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study. ( Barbanti, G; Beneforti, P; Lapini, A; Turini, D, 1988) |
| " When arterial strips were processed by radioimmunoassay for dosage of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) after the relaxing action of the contrast medium occurred, a decrease in cAMP from 2." | 1.26 | Effects of angiographic contrast medium on isolated canine coronary arteries. ( Cingolani, H; Lardani, H; Rinaldi, G, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (24.46) | 18.7374 |
| 1990's | 175 (62.95) | 18.2507 |
| 2000's | 33 (11.87) | 29.6817 |
| 2010's | 2 (0.72) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davey, DD | 1 |
| Erhardt, PW | 1 |
| Cantor, EH | 1 |
| Greenberg, SS | 2 |
| Ingebretsen, WR | 1 |
| Wiggins, J | 1 |
| Reynolds, JN | 1 |
| Bennett, BM | 6 |
| Boegman, RJ | 1 |
| Jhamandas, K | 1 |
| Ratz, JD | 2 |
| Zavorin, SI | 1 |
| Scutaru, D | 1 |
| Dumitrascu, A | 1 |
| Thatcher, GR | 1 |
| Fok, H | 1 |
| Guilcher, A | 1 |
| Li, Y | 3 |
| Brett, S | 1 |
| Shah, A | 1 |
| Clapp, B | 1 |
| Chowienczyk, P | 1 |
| Clift, K | 1 |
| Clift, J | 1 |
| Fornet, I | 1 |
| Ortiz-Gómez, JR | 1 |
| Palacio, FJ | 1 |
| López, MA | 1 |
| Intapad, S | 1 |
| Dimitropoulou, C | 1 |
| Snead, C | 1 |
| Piyachaturawat, P | 1 |
| Catravas, JD | 1 |
| Fujimoto, S | 1 |
| Togane, Y | 1 |
| Matsuzaki, C | 1 |
| Yamashina, S | 1 |
| Nakano, H | 1 |
| Yamazaki, J | 1 |
| Yoshino, G | 1 |
| Madhani, M | 1 |
| Scotland, RS | 1 |
| MacAllister, RJ | 1 |
| Hobbs, AJ | 1 |
| de la Lande, IS | 2 |
| Siebert, TE | 1 |
| Bennett, CL | 1 |
| Stafford, I | 2 |
| Horowitz, JD | 5 |
| Bény, JL | 2 |
| Thorlacius, K | 1 |
| Bodelsson, M | 1 |
| Teixeira, CE | 1 |
| Priviero, FB | 1 |
| Claudino, MA | 1 |
| Baracat, JS | 1 |
| De Nucci, G | 1 |
| Webb, RC | 1 |
| Antunes, E | 1 |
| Ghatta, S | 1 |
| O'Rourke, ST | 2 |
| El-Demerdash, E | 1 |
| Benkó, R | 1 |
| Undi, S | 1 |
| Wolf, M | 1 |
| Magyar, K | 1 |
| Tóvölgyi, Z | 1 |
| Rumbus, Z | 1 |
| Barthó, L | 1 |
| Esplugues, JV | 1 |
| Rocha, M | 1 |
| Nuñez, C | 1 |
| Bosca, I | 1 |
| Ibiza, S | 1 |
| Herance, JR | 1 |
| Ortega, A | 1 |
| Serrador, JM | 1 |
| D'Ocon, P | 1 |
| Victor, VM | 1 |
| George, RB | 1 |
| Melnick, AH | 1 |
| Rose, EC | 1 |
| Habib, AS | 1 |
| Qin, X | 1 |
| Zheng, X | 1 |
| Qi, H | 1 |
| Dou, D | 1 |
| Raj, JU | 1 |
| Gao, Y | 1 |
| Dhawan, S | 1 |
| Chopra, S | 1 |
| Mendes, ES | 1 |
| Horvath, G | 1 |
| Rebolledo, P | 1 |
| Monzon, ME | 1 |
| Casalino-Matsuda, SM | 1 |
| Wanner, A | 1 |
| Gruetter, CA | 5 |
| Kadowitz, PJ | 5 |
| Ignarro, LJ | 7 |
| Ruskoaho, H | 1 |
| Nakamura, Y | 1 |
| Shiraki, Y | 1 |
| Nabata, H | 1 |
| Sakai, K | 1 |
| Shibata, S | 7 |
| Satake, N | 7 |
| Takagi, T | 1 |
| Kerfoot, F | 1 |
| Suh, TK | 1 |
| Braughler, JM | 1 |
| Gruetter, DY | 1 |
| Lyon, JE | 1 |
| Axelsson, KL | 9 |
| Andersson, RG | 7 |
| Wikberg, JE | 3 |
| Keith, RA | 2 |
| Burkman, AM | 2 |
| Sokoloski, TD | 2 |
| Fertel, RH | 2 |
| Lardani, H | 1 |
| Rinaldi, G | 1 |
| Cingolani, H | 1 |
| Diamond, J | 2 |
| Chu, EB | 1 |
| Edwards, JC | 1 |
| Hyman, AL | 1 |
| Burke, TM | 1 |
| Wood, KS | 2 |
| Wolin, MS | 3 |
| Byrick, RJ | 1 |
| Hobbs, EG | 1 |
| Martineau, R | 1 |
| Noble, WH | 1 |
| Moffat, JA | 2 |
| Armstrong, PW | 4 |
| Marks, GS | 12 |
| Muramatsu, I | 2 |
| Fujii, K | 1 |
| Sakakibara, Y | 1 |
| Fujiwara, M | 1 |
| Karaki, H | 1 |
| Murakami, K | 1 |
| Nakagawa, H | 2 |
| Urakawa, N | 1 |
| Gharaibeh, MN | 1 |
| Gross, GJ | 2 |
| Toda, N | 8 |
| Armstrong, JA | 1 |
| Diemer, MJ | 1 |
| Warltier, DC | 1 |
| Hardman, HF | 1 |
| Wessén, A | 2 |
| Elowsson, P | 1 |
| Axemo, P | 2 |
| Lindberg, B | 2 |
| Klockenbusch, W | 1 |
| Schrör, K | 2 |
| La Rochelle, CD | 1 |
| Dubois-Randé, JL | 2 |
| Richard, V | 1 |
| Hittinger, L | 2 |
| Giudicelli, JF | 2 |
| Berdeaux, A | 2 |
| Khan, SA | 1 |
| Mathews, WR | 1 |
| Meisheri, KD | 1 |
| Bauer, JA | 2 |
| Fung, HL | 5 |
| Zheng, W | 1 |
| Kwon, YW | 1 |
| Gopalakrishnan, M | 1 |
| Triggle, DJ | 1 |
| Okamura, T | 6 |
| He, GW | 1 |
| Yang, CQ | 1 |
| Wilson, GJ | 1 |
| Rebeyka, IM | 1 |
| Chabaud, F | 1 |
| Danna, M | 1 |
| Kitamura, Y | 2 |
| Kojda, G | 1 |
| Beck, JK | 1 |
| Meyer, W | 1 |
| Noack, E | 1 |
| Fukuda, S | 2 |
| Sakuma, K | 2 |
| Tsukui, A | 2 |
| Fujiwara, N | 2 |
| Tanaka, T | 2 |
| Fujihara, H | 1 |
| Toriumi, T | 1 |
| Shimoji, K | 2 |
| Li, CG | 2 |
| Brosch, SF | 1 |
| Rand, MJ | 2 |
| Desai, KM | 3 |
| Warner, TD | 2 |
| Bishop, AE | 1 |
| Polak, JM | 1 |
| Vane, JR | 3 |
| Ishibashi, T | 5 |
| Kawada, T | 2 |
| Kato, K | 3 |
| Hamaguchi, M | 2 |
| Imai, S | 6 |
| Bank, AJ | 3 |
| Wilson, RF | 1 |
| Kubo, SH | 2 |
| Holte, JE | 2 |
| Dresing, TJ | 1 |
| Wang, H | 2 |
| Rioux, F | 1 |
| Drapeau, G | 1 |
| Marceau, F | 1 |
| Braun, M | 1 |
| Grosser, T | 1 |
| Singer, AH | 1 |
| Tsao, PS | 1 |
| Wang, BY | 1 |
| Bloch, DA | 1 |
| Cooke, JP | 1 |
| Mercier, FJ | 1 |
| Benhamou, D | 1 |
| Miyauchi, N | 1 |
| Takahashi, M | 2 |
| Fujioka, H | 1 |
| Kinoshita, M | 3 |
| Zhou, Q | 2 |
| Pieper, GM | 6 |
| Peltier, BA | 1 |
| Briejer, MR | 2 |
| Akkermans, LM | 2 |
| Meulemans, AL | 3 |
| Lefebvre, RA | 3 |
| Schuurkes, JA | 3 |
| Dukhanin, AS | 1 |
| Shilo, VIu | 1 |
| Nikitin, VB | 1 |
| Engalycheva, GN | 1 |
| Bell, DR | 1 |
| Rensberger, HJ | 1 |
| Koritnik, DR | 1 |
| Koshy, A | 1 |
| Torfgård, KE | 1 |
| Ahlner, J | 7 |
| Iversen, HH | 1 |
| Gustafsson, LE | 1 |
| Leone, AM | 1 |
| Wiklund, NP | 1 |
| Hussain, AS | 5 |
| Poklewska-Koziell, M | 2 |
| Brien, JF | 10 |
| Nakatsu, K | 10 |
| Sasage, H | 1 |
| Fullerton, DA | 1 |
| Hahn, AR | 1 |
| Banerjee, A | 1 |
| Harken, AH | 1 |
| Salas, E | 1 |
| López, MG | 1 |
| Villarroya, M | 1 |
| Sánchez-García, P | 1 |
| De Pascual, R | 1 |
| Dixon, WR | 1 |
| García, AG | 1 |
| Isono, T | 1 |
| Sato, N | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers[NCT01216735] | 32 participants (Actual) | Interventional | 2008-09-30 | Completed | |||
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Airway Blood flow (Qaw) will be measured before and 15 minutes after albuterol inhalation (delta Qaw). (NCT01216735)
Timeframe: 3 weeks treatment period of ICS or placebo
| Intervention | % change (Mean) |
|---|---|
| Fluticasone | 40.9 |
| Placebo | 0.0 |
Flow-mediated vasodilation response in the brachial artery will be measured before and 15 minutes.after albuterol inhalation (NCT01216735)
Timeframe: 3 weeks of treatment
| Intervention | % change (Mean) |
|---|---|
| Fluticasone | 3.9 |
| Placebo | 4.8 |
5 reviews available for nitroglycerin and Muscle Relaxation
| Article | Year |
|---|---|
Nonsurgical approaches for the treatment of anal fissures.
Topics: Anal Canal; Botulinum Toxins; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Muscle Relaxation; | 2007 |
Mechanisms of action of nitrates.
Topics: Angina Pectoris; Blood Platelets; Cyclic GMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme Syst | 1994 |
The use of intravenous nitroglycerin for cervico-uterine relaxation: a review of the literature.
Topics: Breech Presentation; Cervix Uteri; Cesarean Section; Female; Humans; Infusions, Intravenous; Muscle | 1997 |
The role of nitric oxide synthase/nitric oxide in vascular smooth muscle control.
Topics: Administration, Inhalation; Amyl Nitrite; Arginine; Calcium Signaling; Cardiopulmonary Bypass; Cycli | 2000 |
Glyceryl trinitrate and acute uterine relaxation: a literature review.
Topics: Animals; Cyclic GMP; Female; Hemodynamics; Humans; Muscle Relaxation; Nitric Oxide; Nitroglycerin; O | 2001 |
6 trials available for nitroglycerin and Muscle Relaxation
| Article | Year |
|---|---|
Augmentation pressure is influenced by ventricular contractility/relaxation dynamics: novel mechanism of reduction of pulse pressure by nitrates.
Topics: Adult; Aged; Arterial Pressure; Blood Pressure; Cardiac Catheterization; Dose-Response Relationship, | 2014 |
Assessments of embryo transfer after in-vitro fertilization: effects of glyceryl trinitrate.
Topics: Cervix Uteri; Double-Blind Method; Embryo Transfer; Female; Fertilization in Vitro; Humans; Muscle R | 1993 |
Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy?
Topics: Acute Disease; Administration, Rectal; Administration, Topical; Adult; Anal Canal; Anesthetics, Loca | 1997 |
Nitroglycerin to facilitate fetal extraction during cesarean delivery.
Topics: Adult; Cesarean Section; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Extr | 1998 |
Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Blood | 1999 |
[The local effect of nitroglycerin ointment in dilating veins. A possible aid in establishing drip infusions].
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusions, Parenteral; Male; Muscle C | 1985 |
267 other studies available for nitroglycerin and Muscle Relaxation
| Article | Year |
|---|---|
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aza Compounds; Ca | 1991 |
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cyclic GMP; Dose-Response Relationship, Drug; Guanyl | 2002 |
Uterine relaxation during caesarean section under regional anaesthesia: a survey of UK obstetric anaesthetists.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Cesarean Section; Female; Humans; Muscle Relaxation | 2008 |
[Use of nitroglycerin to facilitate obstetric analgesia].
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Female; Humans; Infant, Newborn; Labor, Induced; | 2008 |
Regulation of asthmatic airway relaxation by estrogen and heat shock protein 90.
Topics: Animals; Asthma; Cells, Cultured; Estradiol; Estrogens; HSP90 Heat-Shock Proteins; Humans; Macrolide | 2012 |
Effects of long-term administration of methionine on vascular endothelium in rabbits.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cysteine; | 2003 |
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, T | 2003 |
Influence of the endothelium on ex vivo tolerance and metabolism of glyceryl trinitrate in rat aorta.
Topics: Animals; Aorta; Chromatography, Gas; Drug Tolerance; Endothelium, Vascular; In Vitro Techniques; Mus | 2004 |
Characterization of purine receptors in mouse thoracic aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine; Adenos | 2004 |
Sevoflurane promotes endothelium-dependent smooth muscle relaxation in isolated human omental arteries and veins.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Arteries; Cyclic GMP; Endothelium, Vascular | 2004 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; | 2006 |
Nitroglycerin-induced release of calcitonin gene-related peptide from sensory nerves attenuates the development of nitrate tolerance.
Topics: Animals; Aorta, Thoracic; Calcitonin Gene-Related Peptide; Capsaicin; Diltiazem; Dose-Response Relat | 2006 |
Evidences for prevention of nitroglycerin tolerance by carvedilol.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Carbazoles; Carvedilol; Drug Interactions; Dr | 2006 |
P(2) purinoceptors account for the non-nitrergic NANC relaxation in the rat ileum.
Topics: Animals; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Ileum; In Vitro Techniq | 2006 |
Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antioxidants; Cyclic GMP; Do | 2006 |
Case series: Combined spinal epidural anesthesia for Cesarean delivery and ex utero intrapartum treatment procedure.
Topics: Adult; Airway Obstruction; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupiva | 2007 |
cGMP-dependent protein kinase in regulation of basal tone and in nitroglycerin- and nitric-oxide-induced relaxation in porcine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blotting, Western; Coro | 2007 |
Effect of an inhaled glucocorticoid on endothelial function in healthy smokers.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Androstadienes; Bronchodilator Agents; End | 2008 |
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite.
Topics: Amyl Nitrite; Animals; Cattle; Coronary Vessels; Enzyme Activation; Guanylate Cyclase; In Vitro Tech | 1981 |
Prevention of cardiac hypertrophy by long-term treatment with isosorbide dinitrate and prazosin but not by minoxidil in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Female; Hypertension; Isosorbide Dinitrate; Male; Minoxidil; | 1984 |
Comparative effects of nicorandil and nitroglycerin on tracheal and vascular smooth muscle in the dog, in vivo and in vitro.
Topics: Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; In Vitro Te | 1984 |
Relaxing effect of nicorandil (N-2-(hydroxyethyl)-nicotinamide nitrate), a new anti-angina agent, on the isolated vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Basilar Artery; Calcium; Cats; Coronary Vessels; In Vitro Techniques; Male | 1984 |
Dissociation of increases in cyclic GMP from relaxation of arterial smooth muscle.
Topics: Animals; Cyclic GMP; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smoot | 1981 |
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; In Vitro Techniques; Methemoglobin; Methylene Blue; M | 1981 |
Correlation between vascular smooth muscle relaxation and increase in cyclic GMP induced by some organic nitro esters.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Ethylene Glycols; In Vitr | 1981 |
Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Male; Methylene Blue; Mus | 1982 |
Vascular smooth muscle relaxation by nitro compounds: reduced relaxation and cGMP elevation in tolerant vessels and reversal of tolerance by dithiothreitol.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dithiothreitol; Drug Tolerance; Ferricyanides; Glutathione; | 1982 |
Effects of angiographic contrast medium on isolated canine coronary arteries.
Topics: Animals; Contrast Media; Coronary Angiography; Coronary Vessels; Cyclic AMP; Dogs; Dose-Response Rel | 1982 |
Nitroglycerin tolerance and cyclic GMP generation in the longitudinal smooth muscle of the guinea-pig ileum.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Female; Guinea Pigs; Ileum; M | 1983 |
Lack of correlation between cyclic GMP elevation and relaxation of nonvascular smooth muscle by nitroglycerin, nitroprusside, hydroxylamine and sodium azide.
Topics: Animals; Azides; Colon; Cyclic GMP; Female; Guinea Pigs; Hydroxylamine; Hydroxylamines; Male; Muscle | 1983 |
Possible role for cyclic GMP in endothelium-dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium; Female; In Vitro Techniques; Male; | 1983 |
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.
Topics: Animals; Cattle; Cyclic GMP; Female; In Vitro Techniques; Mercaptoethanol; Muscle Relaxation; Muscle | 1984 |
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.
Topics: Acetylcholine; Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endotheliu | 1984 |
Nitroglycerin relaxes large airways.
Topics: Adult; Aged; Anesthesia, Intravenous; Blood Pressure; Dose-Response Relationship, Drug; Humans; Midd | 1983 |
Investigation of the role of prostaglandins in nitroglycerin-induced relaxation of isolated rabbit blood vessels.
Topics: Animals; Arachidonic Acids; Bradykinin; Celiac Artery; In Vitro Techniques; Indomethacin; Male; Mese | 1983 |
Vasorelaxing actions of molsidomine and its metabolites, in comparison with nitroglycerin.
Topics: Animals; Calcium; Dogs; Female; Male; Methemoglobin; Methylene Blue; Molsidomine; Muscle Contraction | 1983 |
Nitroglycerine-induced biphasic relaxation in vascular smooth muscle of rat aorta.
Topics: Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, | 1984 |
Comparative relaxant effects of nitroglycerin in isolated rings from various canine vascular beds.
Topics: Animals; Dogs; Female; Femoral Artery; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contra | 1984 |
Responses of human, monkey and dog coronary arteries in vitro to carbocyclic thromboxane A2 and vasodilators.
Topics: Adult; Aged; Animals; Coronary Vessels; Dinoprost; Dogs; Epoprostenol; Female; Humans; In Vitro Tech | 1984 |
Absence of metabolite formation during nitroglycerin-induced relaxation of isolated blood vessels.
Topics: Animals; Biotransformation; Dogs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle | 1980 |
Relaxation of potassium-depolarized canine, bovine and porcine large coronary arteries by nitroglycerin, chromonar and two dihydropyridine calcium antagonists.
Topics: Animals; Calcium; Cattle; Chromonar; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Femal | 1981 |
The use of intravenous nitroglycerin for emergency cervico-uterine relaxation.
Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Cervix Uteri; Emergencies; Female; Humans; Inje | 1995 |
Prostacyclin contributes to nitroglycerin-mediated relaxation of human umbilical arteries.
Topics: Epoprostenol; Female; Humans; In Vitro Techniques; Indomethacin; Molsidomine; Muscle Relaxation; Mus | 1993 |
The role of NO release in the control of large and small coronary artery tone in conscious dogs.
Topics: Acetylcholine; Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascu | 1993 |
Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Charybdotoxin; Colforsin; Drug Interactions | 1993 |
Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels.
Topics: Administration, Cutaneous; Animals; Aorta, Thoracic; Binding Sites; Drug Tolerance; Glyburide; Heart | 1993 |
Responses to perivascular nerve stimulation of distal temporal arteries from dogs and monkeys.
Topics: Adrenergic alpha-Antagonists; Animals; Arginine; Dinoprost; Dogs; Drug Interactions; Electric Stimul | 1993 |
Tolerance of epicardial coronary endothelium and smooth muscle to hyperkalemia.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Vessels; Endothelium, Vasc | 1994 |
A vascular smooth muscles nitric oxide relaxation by a mechanism distinct of calcium changes.
Topics: Acetylcholine; Animals; Arginine; Bradykinin; Calcimycin; Calcium; Coronary Vessels; Cytosol; Dinopr | 1994 |
Role of nitroxidergic nerve in dog retinal arterioles in vivo and arteries in vitro.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arterioles; Atropine; Dogs; Electric Stimulation; End | 1994 |
Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: dependence on intact endothelium.
Topics: Animals; Arginine; Cysteine; Dinoprost; Drug Tolerance; Endothelium, Vascular; In Vitro Techniques; | 1994 |
Hypoxia modifies the vasodilatory effects of nitroglycerin, prostaglandin E1, and hydralazine on isolated porcine coronary arteries.
Topics: Alprostadil; Analysis of Variance; Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelins; H | 1994 |
Inhibition by ethacrynic acid of NO-mediated relaxations of the rat anococcygeus muscle.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cysteine; Drug Interactions; Electric Stimulation; Et | 1994 |
Nitric oxide, and not vasoactive intestinal peptide, as the main neurotransmitter of vagally induced relaxation of the guinea pig stomach.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Electric Stimulation; Gastric Fundus; Guinea Pigs; Im | 1994 |
Contribution of activation of K+ channels to glyceryl trinitrate-induced relaxation of rabbit aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Apamin; Charybdotoxin; Cyclic GMP; En | 1995 |
Direct effects of smooth muscle relaxation and contraction on in vivo human brachial artery elastic properties.
Topics: Adult; Analysis of Variance; Biomechanical Phenomena; Brachial Artery; Compliance; Elasticity; Human | 1995 |
Recombinant human hemoglobin (rHb1.1) selectively inhibits vasorelaxation elicited by nitric oxide donors in rabbit isolated aortic rings.
Topics: Angiotensin I; Animals; Aorta; Captopril; Drug Interactions; Female; Hemoglobins; In Vitro Technique | 1995 |
Bioactivation of nitroglycerin in vascular smooth muscle cells is different from that in non-vascular tissue.
Topics: Animals; Aorta; Biotransformation; Cattle; Cells, Cultured; Coronary Vessels; Cyclic AMP; Cytochrome | 1995 |
Discordant effects of dietary L-arginine on vascular structure and reactivity in hypercholesterolemic rabbits.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Abdominal; Arginine; Cholesterol; Cholesterol, | 1995 |
Nitroglycerin for fetal head entrapment during vaginal breech delivery?
Topics: Breech Presentation; Cesarean Section; Female; Humans; Muscle Relaxation; Nitroglycerin; Obstetric L | 1995 |
Dissociation of hemodynamic and coronary arterial tolerance to nitroglycerin in dogs.
Topics: Animals; Blood Pressure; Coronary Vessels; Cyclic GMP; Dogs; Drug Tolerance; Female; Hemodynamics; I | 1993 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; G | 1995 |
Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium.
Topics: Acetylcholine; Amino Acids; Animals; Arginine; Body Weight; Calcimycin; Diabetes Mellitus, Experimen | 1995 |
5-HT-induced neurogenic relaxations of the guinea-pig proximal colon: investigation into the role of ATP and VIP in addition to nitric oxide.
Topics: Adenosine Triphosphate; Animals; Apamin; Colon; Female; Guinea Pigs; In Vitro Techniques; Isoprotere | 1995 |
[Mechanisms of the vasodilating effect of nitroglycerin and chlorpromazine and features of their interaction in a model of a rat isolated thoracic aorta].
Topics: Animals; Aorta, Thoracic; Chlorpromazine; Dose-Response Relationship, Drug; In Vitro Techniques; Mal | 1994 |
Estrogen pretreatment directly potentiates endothelium-dependent vasorelaxation of porcine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; | 1995 |
Smooth muscle relaxing effects of NO, nitrosothiols and a nerve-induced relaxing factor released in guinea-pig colon.
Topics: Animals; Colon; Cysteine; Electric Stimulation; Female; Guinea Pigs; Half-Life; Hydroxylamine; Hydro | 1994 |
Nitric oxide formation from glyceryl trinitrate by rabbit aortic strip: detection by rabbit taenia coli concurrent with vasorelaxation.
Topics: Animals; Aorta, Thoracic; Biotransformation; Colon; Hemoglobins; In Vitro Techniques; Luminescent Me | 1994 |
Functional role of nerve-derived nitric oxide in isolated dog ophthalmic arteries.
Topics: Animals; Arginine; Autonomic Nervous System; Dogs; Electric Stimulation; Female; Histocytochemistry; | 1995 |
Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit.
Topics: Aminoquinolines; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Drug Interactions; | 1994 |
Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms.
Topics: Alprostadil; Amrinone; Analysis of Variance; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relation | 1994 |
Endothelium-independent relaxation by 17-alpha-estradiol of pig coronary arteries.
Topics: Animals; Aorta, Thoracic; Arginine; Coronary Vessels; Endothelium, Vascular; Estradiol; Female; In V | 1994 |
Tolerance to the vascular effect of a novel nitric oxide-donating vasodilator, FK409.
Topics: Animals; Antihypertensive Agents; Coronary Vessels; Cysteine; Dogs; Dose-Response Relationship, Drug | 1994 |
[Effects of puerarin on cat vascular smooth muscle in vitro].
Topics: Animals; Cats; Dose-Response Relationship, Drug; Female; Femoral Vein; Isoflavones; Isoproterenol; M | 1994 |
Differential vasodilator properties of KRN2391, cromakalim, nitroglycerin and nifedipine in rabbit isolated femoral artery and vein.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Femoral Artery; Femoral Vein; In | 1994 |
5-HT3 receptors do not mediate vagally-induced relaxation or contraction of the isolated stomach of the guinea-pig.
Topics: Animals; Dimethylphenylpiperazinium Iodide; Electric Stimulation; In Vitro Techniques; Male; Metoclo | 1994 |
Rp-8-Br-guanosine-3',5'-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Cyclic GMP; Cyclic GMP-Dependent Protein Kin | 1994 |
Reduced contractile function after balloon denudation of rat carotid arteries.
Topics: Acetylcholine; Animals; Carotid Arteries; Catheterization; In Vitro Techniques; Male; Muscle Contrac | 1994 |
Reduced endothelium-dependent vasodilation by acetylcholine and bradykinin in isolated nitroglycerin-tolerant blood vessels.
Topics: Acetylcholine; Animals; Arginine; Bradykinin; Drug Tolerance; Endothelium, Vascular; In Vitro Techni | 1994 |
Role of NO in vagally-mediated relaxations of guinea-pig stomach.
Topics: Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Arginine; Electric Stimulation; Guinea Pigs | 1993 |
Effect of inhibitors of glutathione S-transferase on glyceryl trinitrate activity in isolated rat aorta.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Enzyme Activation; Glutathione Transferase; Guanylate | 1993 |
Cytosolic Ca2+ transients in endothelium-dependent relaxation of pig coronary artery, and effects of captopril.
Topics: Animals; Bradykinin; Calcium; Captopril; Coronary Vessels; Cytosol; Dinoprost; Dose-Response Relatio | 1993 |
Effect of serum from dogs infected with Dirofilaria immitis on endothelium-dependent relaxation of rat aorta in vitro.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Dirofilariasis; Dog Diseases; Dogs; Endothelium, Vascular; | 1993 |
Nitrate tolerance and aging in isolated rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniqu | 1993 |
Prejunctional modulation of the nitrergic innervation of the canine ileocolonic junction via potassium channels.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Autonomic Nervous System; Colon; Dogs; Electric Stim | 1993 |
Effects of hydroxocobalamin and haemoglobin on no-mediated relaxations in the rat anococcygeus muscle.
Topics: Animals; Arginine; Cysteine; Electric Stimulation; Hemoglobins; Hydroxocobalamin; In Vitro Technique | 1993 |
Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Hydrolysi | 1993 |
Synergistic effect of nisoldipine and nitroglycerin on human internal mammary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Drug Synergism; Humans; In Vitro | 1994 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxatio | 1993 |
Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide.
Topics: Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Light; Male; Muscle Contractio | 1993 |
Putative, selective inhibitors of sarcoplasmic reticulum Ca+(+)-pump ATPase inhibit relaxation by nitroglycerin and atrial natriuretic factor of the rabbit aorta contracted by phenylephrine.
Topics: Adenosine Triphosphatases; Animals; Aorta; Atrial Natriuretic Factor; Calcium; Calcium-Transporting | 1993 |
Effects of halothane on EDRF/cGMP-mediated vascular smooth muscle relaxations.
Topics: Animals; Drug Interactions; Guanosine Monophosphate; Halothane; Male; Muscle Relaxation; Muscle, Smo | 1993 |
Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips.
Topics: Animals; Aorta; Cyclic GMP; Ethacrynic Acid; Glutathione Transferase; In Vitro Techniques; Muscle Re | 1993 |
Interactions of nitrovasodilators and atrial natriuretic peptide in isolated dog coronary arteries.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Coronary Vessels; Cyclic | 1993 |
Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development.
Topics: Animals; Biotransformation; Cattle; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Drug Tol | 1993 |
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
Topics: Acetylcholine; Animals; Bleeding Time; Blood Platelets; Coronary Vessels; Cysteine; Dogs; Female; Ha | 1993 |
Selective and complete blockade of acetylcholine-induced relaxation in rabbit aortic rings by N omega-nitro-L-arginine but not by glybenclamide.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Arginine; Benzopyrans; Cromakalim; Endothelium, Vascular; | 1993 |
Relation between cyclic GMP generation and cerebrovascular reactivity: modulation by NPY and alpha-trinositol.
Topics: Acetylcholine; Animals; Basilar Artery; Brain; Cerebral Arteries; Cerebral Veins; Cyclic GMP; Drug I | 1995 |
Inhibition of nisoldipine on bovine mesenteric arteries and veins and on human peripheral veins.
Topics: Animals; Cattle; Humans; In Vitro Techniques; Mesenteric Arteries; Mesenteric Veins; Muscle Relaxati | 1995 |
Inhibition of non-adrenergic non-cholinergic relaxations by nitric oxide donors.
Topics: Animals; Autonomic Nervous System; Electric Stimulation; Feedback; Gastric Fundus; In Vitro Techniqu | 1995 |
Development of nitrate tolerance in human arteries and veins: comparison of nitroglycerin and SPM 5185.
Topics: Acetylcysteine; Arginine; Dipeptides; Drug Tolerance; Free Radical Scavengers; Humans; In Vitro Tech | 1995 |
Specificity of different organic nitrates to elicit NO formation in rabbit vascular tissues and organs in vivo.
Topics: Animals; Aorta; Blood Vessels; Cysteine; Cytochrome P-450 Enzyme System; Dipeptides; Electron Spin R | 1995 |
Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; In Vitro Techniques; Luminescent Measurements; Male; Molsidomine; Muscle R | 1995 |
Absence of relaxation to lactate in human placental vessels of pregnancies with severe preeclampsia.
Topics: Adult; Arteries; Colforsin; Female; Humans; Infant, Newborn; Infant, Premature; Lactates; Lactic Aci | 1995 |
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Topics: Acetylcholine; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Arginine; Biphenyl Compounds | 1996 |
Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Base Sequence; Endothelium, Vascular; Gly | 1996 |
Effect of angiotensin converting enzyme inhibitors on tolerance of nitroglycerin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Captopril; Drug Tolerance; Enala | 1995 |
Specific binding of nitroglycerin to coronary artery microsomes. Evidence of a vascular nitrate binding site.
Topics: Animals; Binding, Competitive; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Microsome | 1996 |
KATP channel activation mediates nicorandil-induced relaxation of nitrate-tolerant coronary arteries.
Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Drug Tolerance; Glyburide; In Vitro Tec | 1996 |
Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Dose-Response Relationship | 1995 |
Superoxide does not inhibit glyceryl trinitrate-rabbit aortic strip-mediated relaxation of rabbit Taenia coli. Evidence against a role for nitric oxide itself as the smooth muscle active drug metabolite?
Topics: Animals; Aorta, Thoracic; Biotransformation; In Vitro Techniques; Male; Molsidomine; Muscle Relaxati | 1996 |
Characterization of nitroglycerine-induced relaxation in human corpus cavernosum smooth muscle: implications to erectile physiology and dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Erectile Dysfunction; Humans; Kinetics; Male; Middle Aged; Muscle Re | 1995 |
ITF 296, a new endothelium-independent vasodilator: comparison with nitroglycerin and isosorbide dinitrate.
Topics: Animals; Benzoxazines; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Dru | 1995 |
The nitrate ester ITF 296 relaxes isolated canine arteries and veins.
Topics: Animals; Arteries; Benzoxazines; Dogs; Electrophysiology; Endothelium, Vascular; Female; In Vitro Te | 1995 |
Mechanism of ITF 296-induced vasorelaxation compared to nitroglycerin and isosorbide dinitrate: relationship between relaxation of rabbit aorta and tissue cGMP.
Topics: Animals; Aorta, Thoracic; Benzoxazines; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; In Vitro Techniqu | 1995 |
Studies of vascular tolerance to nitroglycerin: effects of N-acetylcysteine, NG-monomethyl L-arginine, and endothelin-1.
Topics: Acetylcysteine; Animals; Aorta; Cyclic GMP; Drug Tolerance; Endothelin-1; Enzyme Inhibitors; Free Ra | 1996 |
Thiacetarsamide depresses relaxation of canine pulmonary artery in vitro.
Topics: Animals; Anthelmintics; Arsenamide; Diethylcarbamazine; Dirofilariasis; Dog Diseases; Dogs; Dose-Res | 1996 |
Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analysis of Variance; Animals; Aorta, Abdominal; Blood Pressure | 1996 |
Effect of Cu2+ on relaxations to the nitrergic neurotransmitter, NO and S-nitrosothiols in the rat gastric fundus.
Topics: Adenosine Triphosphate; Animals; Chelating Agents; Copper Sulfate; Gastric Fundus; In Vitro Techniqu | 1996 |
Effect of thiol modulators and Cu/Zn superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus.
Topics: Animals; Enzyme Inhibitors; Gastric Fundus; Male; Muscle Relaxation; Nitric Oxide; Nitroglycerin; Ra | 1996 |
Utilization of intravenous nitroglycerin for obstetrical emergencies.
Topics: Adult; Breech Presentation; Female; Humans; Muscle Relaxation; Nitroglycerin; Parasympatholytics; Pr | 1996 |
Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modulus.
Topics: Adult; Blood Pressure; Brachial Artery; Collagen; Elasticity; Elastin; Humans; Injections, Intra-Art | 1996 |
Heterogeneity of glyceryl trinitrate response in isolated bovine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Cattle; Cor | 1996 |
Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Endothelium, Vascular; In | 1997 |
Intravenous nitroglycerin for intrapartum internal podalic version of the second non-vertex twin.
Topics: Female; Humans; Infant, Newborn; Muscle Relaxation; Nitroglycerin; Pregnancy; Pregnancy Outcome; Ret | 1996 |
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
Topics: Animals; Aorta; COS Cells; Cyclic GMP; Guanosine Triphosphate; Male; Muscle Relaxation; Muscle, Smoo | 1997 |
Sublingual aerosol nitroglycerin for uterine relaxation in attempted external version.
Topics: Administration, Sublingual; Aerosols; Blood Pressure; Female; Humans; Muscle Relaxation; Nitroglycer | 1997 |
The use of intravenous nitroglycerin for emergency cervico-uterine relaxation.
Topics: Adult; Cervix Uteri; Emergencies; Female; Humans; Injections, Intravenous; Muscle Relaxation; Muscle | 1997 |
Endothelium-dependent relaxation is not uniformly impaired in chronic heart failure.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Dinoprost; Endothelium, Vascular; Heart Failure; Hemodynam | 1997 |
The effect of propofol and thiopentone on impairment by reactive oxygen species of endothelium-dependent relaxation in rat aortic rings.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Endothelium, Vascular; Etomidate; | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Fem | 1997 |
Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Cohort Studies; Diabetes Mellitus, Type 1; Diseas | 1997 |
Lysophosphatidylcholine inhibits receptor-mediated Ca2+ mobilization in intact endothelial cells of rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium; Cattle; Endothelium, Vascular; In Vitro Techniques | 1997 |
Chronic treatment with the 21-aminosteroid U74389F, an inhibitor of lipid peroxidation, does not prevent diabetic endothelial dysfunction.
Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Blood Glucose; Body Weight; Calcimycin; Catal | 1997 |
Thiol agents potentiate glyceryl trinitrate mediated relaxation of rabbit taenia coli: evidence for thiol-dependent biotransformation.
Topics: Animals; Biotransformation; Colon; Drug Synergism; In Vitro Techniques; Male; Muscle Relaxation; Nit | 1997 |
The practice of using nitroglycerin for uterine relaxation.
Topics: Animals; Female; Humans; Muscle Relaxation; Nitroglycerin; Rabbits; Sheep; Uterine Contraction; Uter | 1997 |
The vasodilator effects of clevidipine on human internal mammary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Calcium Channel B | 1997 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.
Topics: Animals; Aorta; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Muscle Relaxation; Muscle, Sm | 1997 |
Vasodilation profile of CD-832, a novel dihydropyridine derivative in rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium Channel Blockers; In Vitro Techniques; | 1997 |
Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus.
Topics: Acetylcholine; Amino Acids; Animals; Aorta, Abdominal; Blood Glucose; Diabetes Mellitus, Experimenta | 1998 |
Effect of nitroglycerin and long-term electrical stimulation on nitrergic relaxation in the pig gastric fundus.
Topics: Animals; Autonomic Nervous System; Cromakalim; Electric Stimulation; Gastric Fundus; In Vitro Techni | 1998 |
Intravenous nitroglycerin for rapid uterine relaxation.
Topics: Cesarean Section; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Injections, | 1998 |
Diverse relaxation responses of canine large and small conductive coronary arteries to glyceryl trinitrate and nitric oxide on the one hand and to 8-bromoguanosine 3':5' cyclic monophosphate on the other.
Topics: Acetylcysteine; Animals; Biotransformation; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Prote | 1998 |
Nitroglycerin to facilitate fetal extraction during cesarean delivery.
Topics: Cesarean Section; Extraction, Obstetrical; Female; Humans; Muscle Relaxation; Muscle, Smooth; Nitrog | 1998 |
Halothane attenuates nitric oxide relaxation of rat aortas by competition for the nitric oxide receptor site on soluble guanylyl cyclase.
Topics: Aminoquinolines; Anesthetics, Inhalation; Animals; Aorta, Thoracic; Binding, Competitive; Cyclic GMP | 1998 |
Cardiovascular activity of WIN 65579, a novel inhibitor of cyclic GMP phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Blood Pressure; Cyclic GMP; Heart Rate; Male; M | 1998 |
[Nitroglycerin ointment is a mild treatment agent for anal fissure. Surgery may cause permanent injury to the internal anal sphincter].
Topics: Administration, Rectal; Anal Canal; Fissure in Ano; Humans; Muscle Relaxation; Nitroglycerin; Ointme | 1998 |
Nitroglycerin-induced aortic relaxation mediated by calcium-activated potassium channel is markedly diminished in hypertensive rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Calcium; Charybdotoxin; Guanylate Cyclase; Hypertension; I | 1998 |
17Beta-estradiol acutely improves endothelium-dependent relaxation to bradykinin in isolated human coronary arteries.
Topics: Adolescent; Adult; Bradykinin; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; E | 1998 |
Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration.
Topics: Acetylcholine; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibi | 1999 |
Glyceryl trinitrate-induced vasodilation is inhibited by ultraviolet irradiation despite enhanced nitric oxide generation: evidence for formation of a nitric oxide conjugate.
Topics: Animals; Biotransformation; Cattle; In Vitro Techniques; Luminescent Measurements; Muscle Relaxation | 1999 |
Possible involvement of nitroglycerin converting step in nitroglycerin tolerance.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Lipopolysacchar | 1999 |
In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation.
Topics: Adult; Blood Pressure; Brachial Artery; Elasticity; Female; Humans; Male; Muscle Relaxation; Muscle, | 1999 |
Increased nitroglycerin-induced relaxation by genistein in rat aortic rings.
Topics: Animals; Aorta; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; | 1999 |
Treatment of odynophagia and dysphagia in advanced cancer with sublingual glyceryl trinitrate.
Topics: Administration, Sublingual; Deglutition Disorders; Female; Humans; Male; Middle Aged; Muscle Relaxat | 1999 |
Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Chelating Agents; Diabetes Mellitus, Experimental; Ele | 1999 |
Effective improvement of the cerebral vasospasm after subarachnoid hemorrhage with low-dose nitroglycerin.
Topics: Administration, Cutaneous; Animals; Basilar Artery; Coronary Angiography; Hemodynamics; In Vitro Tec | 2000 |
Vasodilator effects of organotransition-metal nitrosyl complexes, novel nitric oxide donors.
Topics: Animals; Drug Tolerance; Endothelium, Vascular; Enzyme Inhibitors; Hemoglobins; In Vitro Techniques; | 2000 |
Caldesmon and heat shock protein 20 phosphorylation in nitroglycerin- and magnesium-induced relaxation of swine carotid artery.
Topics: Animals; Calmodulin-Binding Proteins; Carotid Arteries; Heat-Shock Proteins; Histamine; HSP20 Heat-S | 2000 |
Alterations in relaxation to lactate and H(2)O(2) in human placental vessels from gestational diabetic pregnancies.
Topics: Adolescent; Adult; Arachidonic Acid; Colforsin; Diabetes, Gestational; Female; Humans; Hydrogen Pero | 2000 |
Comparison of the relaxation effect in vitro of nitroglycerin vs. fenoterol on human myometrial strips.
Topics: Adrenergic beta-Agonists; Dose-Response Relationship, Drug; Female; Fenoterol; Humans; In Vitro Tech | 2000 |
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biotransformation; Blood Pressure; Cyclic GMP; Drug | 2000 |
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazo | 2001 |
The influence of nitric oxide donors on the responses to nitrergic nerve stimulation in the mouse duodenum.
Topics: Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Enzyme Inhibitors; Ethylm | 2001 |
Relative importance of calcium-activated potassium channels in nipradilol-induced aortic relaxation in rats.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Enzyme Inhibitors; Guanylate Cyclase; In Vitr | 2001 |
Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone.
Topics: Animals; Calcium; Carotid Artery, Common; Colforsin; Cyclic AMP; Cyclic GMP; Heat-Shock Proteins; HS | 2001 |
Nitroglycerin-induced relaxation of anorectal smooth muscle: evidence for apparent lack of tolerance development in the anaesthetized rat.
Topics: Anal Canal; Anesthesia; Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Drug | 2001 |
Anti-atherosclerotic effect of beta-blocker with nitric oxide-releasing action on the severe atherosclerosis.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Arteriosclerosis; Atenolol; Blood Pressure; C | 2002 |
Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Ascorbic Acid; Drug Interactions; Endothelium, Vascular; In | 2002 |
The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: implications for nitrate tolerance.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Glutathione; In Vitro Techniques; Male; Muscle Relaxa | 2002 |
Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Mesenteric Arteries; Musc | 1979 |
Influence of reduction of preload and afterload by nitroglycerin on left ventricular diastolic pressure-volume relations and relaxation in man.
Topics: Adult; Blood Pressure; Blood Volume; Coronary Disease; Heart Ventricles; Hemodynamics; Humans; Male; | 1977 |
Vascular relaxation to omega-3 fatty acids: comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600.
Topics: Animals; Aorta, Thoracic; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Gallop | 1992 |
Effect of diethyldithiocarbamate on the activity of nitric oxide-releasing vasodilators.
Topics: Acetylcholine; Animals; Aorta; Cysteine; Ditiocarb; Male; Muscle Relaxation; Muscle, Smooth, Vascula | 1992 |
Oxygen free radical-mediated selective endothelial dysfunction in isolated coronary artery.
Topics: Acetylcholine; Animals; Bradykinin; Calcimycin; Coronary Vessels; Cyclic N-Oxides; Dogs; Electron Sp | 1992 |
Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Electric Stimulation; Humans; In Vitro Tec | 1992 |
Vasorelaxation by nitroglycerin of the isolated porcine coronary artery during hypoxia.
Topics: Animals; Coronary Vessels; Cyclic GMP; Hypoxia; In Vitro Techniques; Muscle Relaxation; Muscle, Smoo | 1992 |
In vitro and in vivo interactions of nitrovasodilators and zaprinast, a cGMP-selective phosphodiesterase inhibitor.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analysis of Variance; Animals; Coronary Vessels; Dose-Response | 1992 |
Prolonged exposure to catecholamines enhances sensitivity of smooth muscle relaxation induced by sodium nitroprusside and atriopeptin.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Male; | 1992 |
Hepatic cytochrome P-450-mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate.
Topics: Animals; Aorta; Cimetidine; Cytochrome P-450 Enzyme System; Enzyme Activation; Guanylate Cyclase; Ma | 1992 |
Total prevention of the development of in vitro tolerance to organic nitrates. Experiments with antioxidants.
Topics: Animals; Antioxidants; Aorta, Thoracic; Drug Tolerance; Female; Guanylate Cyclase; In Vitro Techniqu | 1992 |
Mode of relaxing action of FK336, a new antianginal agent, in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta; Calcium; Guanylate Cyclase; In Vitro Techniques; Inosine Monophosphat | 1992 |
Inhibition of nitrovasodilator- and acetylcholine-induced relaxation and cyclic GMP accumulation by the cytochrome P-450 substrate, 7-ethoxyresorufin.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Aorta; Biotransformation; Cyclic GMP; Cytochrome P | 1992 |
Involvement of charybdotoxin-sensitive K+ channel in the relaxation of bovine tracheal smooth muscle by glyceryl trinitrate and sodium nitroprusside.
Topics: Animals; Carbachol; Cattle; Charybdotoxin; Drug Interactions; Muscle Relaxation; Muscle, Smooth; Mus | 1992 |
Relaxant effects on iloprost in canine cerebral artery.
Topics: Animals; Basilar Artery; Cerebral Arteries; Dogs; Female; Iloprost; In Vitro Techniques; Male; Muscl | 1992 |
Impaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol.
Topics: Acetylcholine; Allopurinol; Amlodipine; Animals; Calcium Channel Blockers; Coronary Disease; Coronar | 1992 |
Kinetics of relaxation responses to vasorelaxants in isolated rabbit aorta.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; Dose-Response Relationship, | 1992 |
Nitric oxide is involved in 5-HT-induced relaxations of the guinea-pig colon ascendens in vitro.
Topics: Animals; Arginine; Colon; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Isoproterenol; Male | 1992 |
Possibilities of the tolerance development to nipradilol and of the measurement of vascular glutathione content in isolated rat aorta.
Topics: Animals; Aorta, Thoracic; Drug Tolerance; Glutathione; In Vitro Techniques; Male; Muscle Contraction | 1992 |
Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase.
Topics: Animals; Glutathione; Glutathione Transferase; Indocyanine Green; Ketones; Muscle Relaxation; Muscle | 1992 |
Impaired vascular reactivity following angioplasty is mainly due to endothelial injury.
Topics: Acetylcholine; Angioplasty, Balloon, Coronary; Animals; Blood Platelets; Dogs; Endothelium, Vascular | 1992 |
Inhibition of endothelium-dependent vasorelaxation by arginine analogues: a pharmacological analysis of agonist and tissue dependence.
Topics: Acetylcholine; Alkylation; Animals; Aorta, Thoracic; Arginine; Glyburide; In Vitro Techniques; Indom | 1992 |
Effects of metabolic inhibitors on endothelium-dependent and endothelium-independent vasodilatation of rat and rabbit aorta.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Antimetabolites; Aorta, Thoracic; Bu | 1991 |
The mode of vasorelaxing action of melatonin in rabbit aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Dinoprost; In Vitro Techniques; Male; Melatonin | 1991 |
Ouabain, Na(+)-free and K(+)-free solutions and relaxations to nitric oxide and nitrovasodilators.
Topics: Animals; Coronary Vessels; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Co | 1991 |
Role of nitric oxide in neurally induced cerebroarterial relaxation.
Topics: Animals; Arginine; Calcimycin; Cerebral Arteries; Cyclic GMP; Dogs; Female; Male; Muscle Relaxation; | 1991 |
Reversal or nitroglycerin tolerance by the cGMP phosphodiesterase inhibitor zaprinast.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Drug Tolerance; In Vitro Techniques; M | 1991 |
Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Endothelium, Vascular; In Vitro Techniques; Mal | 1991 |
Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Activa | 1991 |
Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Drug Synergism; Female; Guanylate Cy | 1991 |
Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-GMP Phosphodiestera | 1991 |
Vascular nitric oxide-generating activities for organic nitrites and organic nitrates are distinct.
Topics: Amyl Nitrite; Animals; Cattle; Coronary Vessels; Cysteine; Cytosol; Hot Temperature; In Vitro Techni | 1991 |
Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin.
Topics: Animals; Coronary Vessels; Endothelins; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Heart; | 1991 |
Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig.
Topics: Animals; Arginine; Atropine; Guanethidine; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In V | 1991 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitra | 1990 |
Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation.
Topics: Animals; Aorta, Thoracic; Biotransformation; Cattle; Cyclic GMP; In Vitro Techniques; Male; Muscle R | 1990 |
Effects of in vivo SIN1 treatment on nitrovasodilator relaxation and on EDRF-mediated responses in rat aorta.
Topics: Animals; Aorta, Thoracic; Drug Evaluation, Preclinical; Drug Tolerance; Enzyme Activation; Guanylate | 1990 |
Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Calcimycin; Cholesterol | 1990 |
Comparison of endothelium-dependent responses of monkey cerebral and temporal arteries.
Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcimycin; Cerebral Arteries | 1991 |
Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators.
Topics: Animals; Bradykinin; Calcimycin; Cholesterol; Coronary Vessels; Endothelium, Vascular; Hyperlipidemi | 1991 |
Uterine relaxation can be life saving.
Topics: Cesarean Section; Female; Humans; Muscle Relaxation; Muscle, Smooth; Nitroglycerin; Obstetric Labor | 1991 |
Captopril does not modify endothelial dependent vascular reactivity in spontaneous hypertensive rat (SHR).
Topics: Acetylcholine; Animals; Aorta, Thoracic; Captopril; Endothelium, Vascular; In Vitro Techniques; Musc | 1991 |
Recovery of vascular smooth muscle relaxation from nitroglycerin-induced tolerance following a drug-free interval. A time-course in vitro study.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Epinephrine; Muscle Relaxation; | 1991 |
Bioassay of nitric oxide released upon stimulation of non-adrenergic non-cholinergic nerves in the canine ileocolonic junction.
Topics: Animals; Aorta, Thoracic; Autonomic Nervous System; Colon; Dimethylphenylpiperazinium Iodide; Dogs; | 1991 |
Spasmolytic effect of cromakalim in dog coronary artery in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Coronary V | 1991 |
Effect of the molsidomine metabolite SIN-1 on coronary arteries and peripheral vessels of sheep with special reference to tolerance and endothelium.
Topics: Animals; Blood Vessels; Coronary Vessels; Dose-Response Relationship, Drug; Drug Tolerance; Endothel | 1991 |
Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosp | 1991 |
Effect of tolerance to glyceryl trinitrate on vascular responses in conscious rabbits.
Topics: Administration, Cutaneous; Animals; Aorta, Thoracic; Consciousness; Drug Tolerance; Endothelium, Vas | 1991 |
Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride.
Topics: Acetylcholine; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Coronary Vessels | 1990 |
Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcimycin; Humans; In Vitro Techniques; Lipoproteins, LDL; | 1990 |
Relaxation of bovine mesenteric arteries by glyceryl trinitrate and other nitro-compounds: evidence for partly different mechanisms of action.
Topics: Aminoquinolines; Animals; Cattle; Female; Isosorbide Dinitrate; Mesenteric Arteries; Mice; Muscle Re | 1990 |
Vasodilator and antihypertensive actions of 3-nitropropionic acid.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Dogs; Heart Rate; Hypertension, R | 1990 |
Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure.
Topics: Acetylcholine; Animals; Cardiac Pacing, Artificial; Coronary Vessels; Dinoprost; Dogs; Endothelium, | 1990 |
Different time course of atrial natriuretic factor-induced relaxation in rabbit aorta and portal vein.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; In Vitro Techniques; Muscle Contraction; Muscle | 1990 |
Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Down-Regulation; Male; Muscle Relax | 1990 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; B | 1986 |
N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings.
Topics: Acetylcysteine; Animals; Dogs; Drug Interactions; Drug Tolerance; In Vitro Techniques; Muscle Contra | 1987 |
Development of a large fibromuscular intimal thickening does not impair endothelium-dependent relaxation in the rabbit carotid artery.
Topics: Animals; Calcimycin; Carotid Arteries; Endothelium; Male; Methacholine Chloride; Methacholine Compou | 1987 |
Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery.
Topics: Acetylcholine; Alprostadil; Animals; Biological Products; Celiac Artery; Female; Gossypol; In Vitro | 1987 |
Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium, Vascular; Histamine; Male; Muscle | 1987 |
[Action of nitroglycerin and sodium nitroprusside on the smooth muscle cells of the intestines].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Ferricyanides; Guinea Pigs; Ion Channels; Membra | 1987 |
Differential inhibitory effects of nitroglycerin on contractile responses to the alpha-adrenoceptor agonists, methoxamine and clonidine, in rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Calcium Radioisotopes; Clonidine; Egtazic Acid; In Vitr | 1989 |
Determinants of in vitro nitroglycerin tolerance induction and reversal: influence of dose regimen, nitrate-free period, and sulfhydryl supplementation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcysteine; Animals; Cattle; | 1989 |
Responsiveness of peripheral veins to transdermal and sublingual nitroglycerin in healthy male volunteers.
Topics: Administration, Cutaneous; Administration, Sublingual; Adult; Blood Pressure; Hand; Heart Rate; Huma | 1989 |
Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways.
Topics: Animals; Carbachol; Cattle; Dose-Response Relationship, Drug; Ferricyanides; In Vitro Techniques; Is | 1989 |
Synthetic nitrovasodilators are effective, in vitro, in relaxing penile tissue from impotent men: the findings and their implications.
Topics: Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; In Vitro Techniques; Isosorbide Dini | 1989 |
Dirofilaria immitis: alteration of endothelium-dependent relaxation in the in vivo canine femoral artery.
Topics: Acetylcholine; Animals; Dirofilaria immitis; Dirofilariasis; Dogs; Endothelium, Vascular; Epoprosten | 1989 |
L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation.
Topics: Acetylcholine; Animals; Arginine; Argininosuccinic Acid; Calcimycin; Cattle; Endothelium, Vascular; | 1989 |
Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase.
Topics: Animals; Aorta; Glutathione; Glutathione Transferase; In Vitro Techniques; Muscle Relaxation; Nitrog | 1989 |
Histamine relaxation of aortic rings from diabetic rats.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diphenhydramine; Endothelium, Vascular; H | 1989 |
Nitroglycerin relaxes canine coronary arterial smooth muscle without reducing intracellular Ca2+ concentrations measured with fura-2.
Topics: Animals; Benzofurans; Calcium; Coronary Vessels; Dogs; Female; Fura-2; In Vitro Techniques; Male; Mu | 1989 |
S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Cattle; Chromatography, High Pressure Liquid; Coronary Vesse | 1989 |
Studies on the biphasic relaxant curve of glyceryl trinitrate in rat aorta: role of GTN metabolites.
Topics: Animals; Aorta, Thoracic; Drug Tolerance; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smoo | 1989 |
Actions of a newly synthesized nitro-compound, E-4701, on rabbit vascular smooth muscles.
Topics: Acetylcholine; Animals; Calcium; Coronary Circulation; Dioxanes; Dioxins; Membrane Potentials; Mesen | 1989 |
Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates.
Topics: Animals; Aorta, Thoracic; Biotransformation; Chromatography, Thin Layer; Drug Tolerance; In Vitro Te | 1989 |
Beta-migrating very low density lipoprotein attenuates endothelium-dependent relaxation in rabbit atherosclerotic aortas.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; | 1989 |
[Two types of relaxation responses mediated by cyclic GMP in cerebral arteries].
Topics: Adult; Aged; Animals; Basilar Artery; Calcimycin; Cerebral Arteries; Child, Preschool; Cyclic GMP; D | 1989 |
Relaxation of bovine mesenteric artery induced by glyceryl trinitrate is attenuated by pertussis toxin.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Mesenteric Arteries; Muscle Relaxation | 1988 |
Glyceryl trinitrate inhibits phosphatidylinositol hydrolysis and protein kinase C activity in bovine mesenteric artery.
Topics: Animals; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Inositol Phospha | 1988 |
Some actions of sodium nitroprusside and glyceryl trinitrate on guinea-pig isolated trachealis muscle.
Topics: Aminophylline; Animals; Ethacrynic Acid; Female; Ferricyanides; Guinea Pigs; In Vitro Techniques; Is | 1985 |
Stimulation of soluble coronary arterial guanylate cyclase by SIN-1.
Topics: Animals; Cations, Divalent; Cattle; Coronary Vessels; Cyclic GMP; Ferricyanides; Guanylate Cyclase; | 1986 |
The relaxant effect of glyceryltrinitrate on isolated human peripheral vein and its relation to cyclic GMP metabolism.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Cyclic GMP; Dose-Response | 1986 |
Mechanism of vasodilation by molsidomine.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Molsidomine; Mus | 1985 |
Dissociation of cysteine and glutathione levels from nitroglycerin-induced relaxation.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Cysteine; Disulfides; Glutathione; Muscle Relaxation; | 1985 |
Effects of sulfhydryl reagents on nitroglycerin-induced relaxation of bovine coronary artery.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Ethacrynic Acid; Ethylmaleimide; In Vitro Techniques; | 1986 |
Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man.
Topics: Adult; Aged; Aging; Cyclic AMP; Humans; Isoproterenol; Male; Middle Aged; Muscle Relaxation; Muscle, | 1986 |
Role of cyclic GMP of canine vascular smooth muscle in relaxation by organic nitrates.
Topics: Animals; Cyclic AMP; Cyclic GMP; Dogs; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; | 1986 |
Studies on the effect of different inhibitors of arachidonic acid metabolism on glyceryltrinitrate-induced relaxation and cGMP elevation in bovine vascular tissue.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Vessels; Cattle; Cyclic GMP; In Vitro Techniques; Masopro | 1987 |
Influence of endothelium on drug-induced relaxation of the rabbit aorta.
Topics: Animals; Aorta, Thoracic; Endothelium; Female; In Vitro Techniques; Isometric Contraction; Isoproter | 1986 |
Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates.
Topics: Acetylcholine; Animals; Arteriosclerosis; Diet, Atherogenic; Dose-Response Relationship, Drug; Endot | 1986 |
Different sensitivities of arteries and veins to glyceryltrinitrate-induced relaxation and tolerance: an "in vitro" study on isolated vessels from rabbits.
Topics: Animals; Arteries; Cysteine; Drug Tolerance; In Vitro Techniques; Indomethacin; Muscle Relaxation; M | 1987 |
A comparative study of glyceryl trinitrate biotransformation and glyceryl trinitrate induced relaxation in bovine pulmonary artery and vein.
Topics: Animals; Biotransformation; Cattle; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Musc | 1987 |
Retention and subsequent liberation of glyceryl trinitrate in organ baths influences the relaxation of bovine mesenteric arteries contracted by various agents.
Topics: Animals; Cattle; Dinoprost; In Vitro Techniques; Mesenteric Arteries; Muscle Relaxation; Muscle, Smo | 1987 |
EDRF generation and release from perfused bovine pulmonary artery and vein.
Topics: Animals; Biological Products; Calcimycin; Cattle; In Vitro Techniques; Muscle Contraction; Muscle Re | 1988 |
Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study.
Topics: Adult; Aged; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; | 1988 |
Leukotriene D4 relaxes canine renal and superior mesenteric arteries.
Topics: Acetylcholine; Animals; Chromones; Dogs; Dose-Response Relationship, Drug; Female; Indomethacin; Mal | 1985 |
The regional difference of relaxations induced by various vasodilators in isolated dog coronary and mesenteric arteries.
Topics: Adenosine; Alprostadil; Animals; Coronary Vessels; Diltiazem; Dogs; Epoprostenol; Female; In Vitro T | 1985 |