Page last updated: 2024-11-01

nitroglycerin and Methemoglobinemia

nitroglycerin has been researched along with Methemoglobinemia in 20 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"This is a case report of methemoglobinemia presumably caused by the combined use of prilocaine (propitocaine) and nitroglycerin under general anesthesia."7.96A Case of Methemoglobinemia Thought to Have Been Caused by the Combined Use of Propitocaine and Nitroglycerin During General Anesthesia. ( Fujisawa, T; Hojo, T; Kimura, Y; Ohiwa, D, 2020)
"The case of a patient is presented who was undergoing coronary bypass grafting and who, during cardiopulmonary bypass, became severely cyanotic because of methemoglobinemia after intravenous infusion of nitroglycerin."7.67Acute methemoglobinemia during cardiopulmonary bypass caused by intravenous nitroglycerin infusion. ( Robicsek, F, 1985)
" Methemoglobinemia in those patients receiving intravenous nitroglycerin may seriously impair oxygen delivery and is not always accompanied by cyanosis in anemic patients."4.78Toxic effects of drugs used in the ICU. Nitroprusside, nitroglycerin, and angiotensin-converting enzyme inhibitors. ( Arnold-Capell, P; Curry, SC, 1991)
"This is a case report of methemoglobinemia presumably caused by the combined use of prilocaine (propitocaine) and nitroglycerin under general anesthesia."3.96A Case of Methemoglobinemia Thought to Have Been Caused by the Combined Use of Propitocaine and Nitroglycerin During General Anesthesia. ( Fujisawa, T; Hojo, T; Kimura, Y; Ohiwa, D, 2020)
"The case of a patient is presented who was undergoing coronary bypass grafting and who, during cardiopulmonary bypass, became severely cyanotic because of methemoglobinemia after intravenous infusion of nitroglycerin."3.67Acute methemoglobinemia during cardiopulmonary bypass caused by intravenous nitroglycerin infusion. ( Robicsek, F, 1985)
" No adverse effects were seen in dogs given up to 1 mg/kd/day of TNG for 4 weeks, then 5 mg/kg/day for 9 more weeks."1.27Subacute and chronic toxicity studies of trinitroglycerin in dogs, rats, and mice. ( Dacre, JC; Ellis, HV; Glennon, JP; Hong, CB; Lee, CC, 1984)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199016 (80.00)18.7374
1990's1 (5.00)18.2507
2000's1 (5.00)29.6817
2010's0 (0.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Pereira, SS1
Yeldo, B1
Aladangady, N1
Hojo, T1
Kimura, Y1
Ohiwa, D1
Fujisawa, T1
HOLM, LW1
JOHNSON, LF1
CRITCHLOW, JK1
Badii, F1
Maghelli, S1
Costa, N1
Borreggine, D1
Zoccali, G1
Durì, D1
Pasch, T1
Hoppelshäuser, G1
Ellis, HV1
Hong, CB1
Lee, CC1
Dacre, JC1
Glennon, JP1
Zurick, AM1
Wagner, RH1
Starr, NJ1
Lytle, B1
Estafanous, FG1
Marshall, JB1
Ecklund, RE1
Yamamura, Y1
Nagara, M1
Fujita, M1
Jost, U1
Gibson, GR1
Hunter, JB1
Raabe, DS1
Manjoney, DL1
Ittleman, FP1
Husum, B1
Lindeburg, T1
Jacobsen, E1
Curry, SC1
Arnold-Capell, P1
Paris, PM1
Kaplan, RM1
Stewart, RD1
Weiss, LD1
Kaplan, K1
Davison, R2
Bojar, RM1
Rastegar, H1
Payne, DD1
Harkness, SH1
England, MR1
Stetz, JJ1
Weiner, B1
Cleveland, RJ1
Kassirer, JP1
Kopelman, RI1
Kaplan, KJ1
Taber, M1
Teagarden, JR1
Parker, M1
Benjamin, E1
Iberti, TJ1
Robicsek, F1

Reviews

1 review available for nitroglycerin and Methemoglobinemia

ArticleYear
Toxic effects of drugs used in the ICU. Nitroprusside, nitroglycerin, and angiotensin-converting enzyme inhibitors.
    Critical care clinics, 1991, Volume: 7, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Critical Care; Cyanides; Humans; Infusions, Intravenous; I

1991

Other Studies

19 other studies available for nitroglycerin and Methemoglobinemia

ArticleYear
Methaemoglobinaemia associated with use of glyceryl trinitrate patches in an extremely preterm infant.
    Journal of paediatrics and child health, 2022, Volume: 58, Issue:10

    Topics: Administration, Cutaneous; Humans; Infant, Extremely Premature; Infant, Newborn; Methemoglobinemia;

2022
A Case of Methemoglobinemia Thought to Have Been Caused by the Combined Use of Propitocaine and Nitroglycerin During General Anesthesia.
    Anesthesia progress, 2020, 09-01, Volume: 67, Issue:3

    Topics: Anesthesia, General; Anesthetics, Local; Humans; Methemoglobinemia; Nitroglycerin; Prilocaine; Think

2020
Experimental poisoning of cattle and sheep with dynamite.
    The Cornell veterinarian, 1952, Volume: 42, Issue:1

    Topics: Animals; Cattle; Methemoglobinemia; Nitrates; Nitroglycerin; Sheep; Sheep, Domestic

1952
Acute methemoglobinemia after nitroglycerine transcutaneous absorption after bomb explosion: a case report.
    The Journal of trauma, 2009, Volume: 66, Issue:3

    Topics: Blast Injuries; Bombs; Burns; Foreign Bodies; Humans; Male; Methemoglobin; Methemoglobinemia; Methyl

2009
Methaemoglobin levels during nitroglycerin infusion for the intraoperative induction of controlled hypotension.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:6

    Topics: Adolescent; Adult; Aged; Female; Humans; Hypotension, Controlled; Infusions, Parenteral; Male; Methe

1983
Subacute and chronic toxicity studies of trinitroglycerin in dogs, rats, and mice.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 1

    Topics: Animals; Blood Cell Count; Body Weight; Diet; Dogs; Eating; Female; Liver; Male; Methemoglobin; Meth

1984
Intravenous nitroglycerin, methemoglobinemia, and respiratory distress in a postoperative cardiac surgical patient.
    Anesthesiology, 1984, Volume: 61, Issue:4

    Topics: Cardiac Surgical Procedures; Humans; Infusions, Parenteral; Male; Methemoglobinemia; Methylene Blue;

1984
Methemoglobinemia from overdose of nitroglycerin.
    JAMA, 1980, Jul-25, Volume: 244, Issue:4

    Topics: Aged; Cytochrome-B(5) Reductase; Humans; Male; Methemoglobinemia; Nitroglycerin

1980
[Methemoglobin content, NADH-methemoglobin reductase activity and glyceryl trinitrate in human blood (author's transl)].
    Masui. The Japanese journal of anesthesiology, 1980, Volume: 29, Issue:6

    Topics: Adult; Cytochrome-B(5) Reductase; Female; Humans; Hypothermia, Induced; Infusions, Parenteral; Male;

1980
[Methemoglobin formation in nitroglycerin infusions. Remarks on the work of The, G.S., G. Spring: Nitroglycerin poisoning after controlled hypotension].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:4

    Topics: Humans; Hypotension, Controlled; Male; Methemoglobinemia; Nitroglycerin

1981
Methemoglobinemia produced by high-dose intravenous nitroglycerin.
    Annals of internal medicine, 1982, Volume: 96, Issue:5

    Topics: Angina Pectoris; Cytochrome-B(5) Reductase; Genetic Carrier Screening; Humans; Infusions, Parenteral

1982
Methaemoglobin formation after nitroglycerin infusion.
    British journal of anaesthesia, 1982, Volume: 54, Issue:5

    Topics: Adult; Female; Humans; Methemoglobinemia; Nitroglycerin

1982
Methemoglobin levels following sublingual nitroglycerin in human volunteers.
    Annals of emergency medicine, 1986, Volume: 15, Issue:2

    Topics: Adult; Blood Pressure; Bradycardia; Heart Rate; Humans; Male; Methemoglobinemia; Nitroglycerin; Time

1986
Nitroglycerin and methemoglobinemia.
    The American journal of cardiology, 1986, Apr-15, Volume: 57, Issue:11

    Topics: Humans; Infusions, Parenteral; Methemoglobin; Methemoglobinemia; Nitroglycerin

1986
Methemoglobinemia from intravenous nitroglycerin: a word of caution.
    The Annals of thoracic surgery, 1987, Volume: 43, Issue:3

    Topics: Aged; Coronary Artery Bypass; Humans; Hypoxia; Infusions, Intravenous; Intraoperative Complications;

1987
Memory: how we overcome its limitations.
    Hospital practice (Office ed.), 1988, May-15, Volume: 23, Issue:5

    Topics: Diagnosis; Humans; Intra-Aortic Balloon Pumping; Male; Memory; Methemoglobinemia; Middle Aged; Myoca

1988
Association of methemoglobinemia and intravenous nitroglycerin administration.
    The American journal of cardiology, 1985, Jan-01, Volume: 55, Issue:1

    Topics: Aged; Angina Pectoris; Angina, Unstable; Female; Humans; Injections, Intravenous; Male; Methemoglobi

1985
Methemoglobinemia and respiratory failure.
    Anesthesiology, 1985, Volume: 62, Issue:4

    Topics: Humans; Methemoglobinemia; Nitroglycerin; Nitroprusside; Respiratory Insufficiency

1985
Acute methemoglobinemia during cardiopulmonary bypass caused by intravenous nitroglycerin infusion.
    The Journal of thoracic and cardiovascular surgery, 1985, Volume: 90, Issue:6

    Topics: Acute Disease; Cardiopulmonary Bypass; Humans; Infusions, Parenteral; Intraoperative Complications;

1985