Page last updated: 2024-11-01

nitroglycerin and Marfan Syndrome

nitroglycerin has been researched along with Marfan Syndrome in 3 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue. Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2.

Research Excerpts

ExcerptRelevanceReference
" Measurements were taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the upstream brachial artery) and after sublingual administration of the endothelium-independent vasodilator nitroglycerin."3.70Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation. ( Bellamy, MF; Brownlee, M; Davies, S; Goodfellow, J; Lewis, MJ; Ramsey, MW; Stuart, AG; Wilson, DG; Wilson, JF, 1999)
"The antenatal diagnosis of aortic dissection carries a grave prognosis."1.39Successful management of aortic dissection in a patient with Marfan syndrome during pregnancy. ( Chang, CY; Chen, PH; Lam, CW; Yang, JM, 2013)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, CY1
Yang, JM1
Lam, CW1
Chen, PH1
Payne, RA1
Hilling-Smith, RC1
Webb, DJ1
Maxwell, SR1
Denvir, MA1
Wilson, DG1
Bellamy, MF1
Ramsey, MW1
Goodfellow, J1
Brownlee, M1
Davies, S1
Wilson, JF1
Lewis, MJ1
Stuart, AG1

Other Studies

3 other studies available for nitroglycerin and Marfan Syndrome

ArticleYear
Successful management of aortic dissection in a patient with Marfan syndrome during pregnancy.
    American journal of obstetrics and gynecology, 2013, Volume: 208, Issue:2

    Topics: Adult; Aortic Aneurysm; Aortic Dissection; Blood Pressure; Calcium Channel Blockers; Coronary Angiog

2013
Augmentation index assessed by applanation tonometry is elevated in Marfan Syndrome.
    Journal of cardiothoracic surgery, 2007, Oct-23, Volume: 2

    Topics: Adolescent; Adult; Blood Pressure; Carotid Arteries; Case-Control Studies; Echocardiography; Elastic

2007
Endothelial function in Marfan syndrome: selective impairment of flow-mediated vasodilation.
    Circulation, 1999, Feb-23, Volume: 99, Issue:7

    Topics: Acetylcholine; Adolescent; Adult; Brachial Artery; Bradykinin; Child; Endothelium, Vascular; Female;

1999