nitroglycerin has been researched along with Liver Cirrhosis in 33 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured the haemodynamic changes following triglycyllysine vasopressin administration and after addition of nitroglycerin in twelve patients with portal hypertension due to hepatitis B-related cirrhosis." | 7.68 | Systemic and portal haemodynamic changes following triglycyllysine vasopressin plus nitroglycerin administration in patients with hepatitis B-related cirrhosis. ( Chang, TT; Lay, CS; Lee, FY; Lee, SD; Lin, HC; Lo, KJ; Tsai, YT; Wang, SS, 1990) |
| " The different peripheric vascular effect found in the two groups was considered as a consequence of the increased drug bioavailability in cirrhotics, caused by portosystemic shunts." | 5.27 | [Strain-gauge plethysmographic measurement of the systemic bioavailability of oral nitroglycerin in liver cirrhosis]. ( Albano, O; Altomare, E; Buonamico, P; Carbone, P; D'Ercole, M; Palasciano, G; Portincasa, P; Pugliese, D; Sabba', C; Stufano, N, 1983) |
| "Utilization data linked to the results of a double-blind, placebo-controlled trial demonstrating the efficacy of the terlipressin-glycerin trinitrate combination (TER-GTN) in the reduction of mortality at day 42 for haemorragic patients due to rupture of oesophageal varices." | 5.09 | Cost-effectiveness analysis of the terlipressin-glycerin trinitrate combination in the pre-hospital management of acute gastro-intestinal haemorrhage in cirrhotic patients. ( Combier, E; de Pouvourville, G; Joseph, A; Letoumelin, P; Levacher, S; Pourriat, JL, 1999) |
| " Oral spironolactone plus transdermal nitroglycerin were given to patients who had diffuse mucosal cherry-red spots and/or rectal varices." | 3.70 | Relationship of portal pressure and colorectal vasculopathy in patients with cirrhosis. ( Makino, H; Nishio, M; Sugano, S; Suzuki, T, 1999) |
| "This study shows that nitroglycerin, given as transdermal long-acting system, significantly influences portal hemodynamics in liver cirrhosis." | 3.69 | Transdermal nitroglycerin in cirrhosis. A 24-hour echo-Doppler study of splanchnic hemodynamics. ( Ghigi, G; Magalotti, D; Marchesini, G; Pisi, E; Zoli, M, 1996) |
| "We measured the haemodynamic changes following triglycyllysine vasopressin administration and after addition of nitroglycerin in twelve patients with portal hypertension due to hepatitis B-related cirrhosis." | 3.68 | Systemic and portal haemodynamic changes following triglycyllysine vasopressin plus nitroglycerin administration in patients with hepatitis B-related cirrhosis. ( Chang, TT; Lay, CS; Lee, FY; Lee, SD; Lin, HC; Lo, KJ; Tsai, YT; Wang, SS, 1990) |
| " The wedged hepatic venous pressure decreased after dosing by 7." | 2.68 | Portal and systemic hemodynamic responses to a very low dose of nitroglycerin in cirrhotic patients with portal hypertension. ( Aramaki, T; Katsuta, Y; Kurokawa, H; Sekiyama, T, 1995) |
| "In conclusion, chronic administration of organic nitrates, allowing for a nitrate-free interval each day, to cirrhotic patients reduces portal pressure with a variable, dose-dependent effect on azygos blood flow." | 2.39 | Organic nitrates in portal hypertension. ( Hayes, PC; Jones, AL, 1994) |
| "The percentage area of liver fibrosis was also significantly reduced in GTN-treated mice (5." | 1.42 | Improvement of hepatocyte transplantation efficiency in the mdr2-/- mouse model by glyceryl trinitrate. ( Boudechiche, L; Branchereau, S; Dagher, I; Davit-Spraul, A; Groyer-Picard, MT; Hadchouel, M; Laïnas, P; Tranchart, H; Weber, A, 2015) |
| " Glyceryl trinitrate (GTN) that is normally subject to first pass elimination, may exhibit higher bioavailability in these patients." | 1.31 | Noninvasive evaluation of portal-systemic shunting by glyceryl trinitrate. ( Aubrecht, J; Perlík, F; Slanar, O, 2002) |
| "Gallbladder hypocontractility in liver cirrhosis is related to the severity of the disease." | 1.30 | Gallbladder hyporesponsiveness to an exogenous nitric oxide donor, glyceryl trinitrate, in patients with advanced liver cirrhosis. ( Acalovschi, M; Hamoudi, WT; Spirchez, Z, 1999) |
| "Nitroglycerin infusion was accompanied by a significant decrease in cardiac output (-21%), systemic O2 transport (-26%) and O2 uptake (-10%), whereas O2 extraction ratio (+18%) and arterial lactate concentration (+31%) significantly increased." | 1.28 | Relationship between oxygen transport and oxygen uptake in patients with cirrhosis: effects of vasoactive drugs. ( Hadengue, A; Lebrec, D; Lee, SS; Moreau, R; Ozier, Y; Sicot, C, 1989) |
| " The different peripheric vascular effect found in the two groups was considered as a consequence of the increased drug bioavailability in cirrhotics, caused by portosystemic shunts." | 1.27 | [Strain-gauge plethysmographic measurement of the systemic bioavailability of oral nitroglycerin in liver cirrhosis]. ( Albano, O; Altomare, E; Buonamico, P; Carbone, P; D'Ercole, M; Palasciano, G; Portincasa, P; Pugliese, D; Sabba', C; Stufano, N, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (21.21) | 18.7374 |
| 1990's | 22 (66.67) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boudechiche, L | 1 |
| Tranchart, H | 1 |
| Branchereau, S | 1 |
| Davit-Spraul, A | 1 |
| Laïnas, P | 1 |
| Groyer-Picard, MT | 1 |
| Weber, A | 1 |
| Hadchouel, M | 1 |
| Dagher, I | 1 |
| Brensing, KA | 1 |
| Hörsch, M | 1 |
| Textor, J | 1 |
| Schiedermaier, P | 1 |
| Raab, P | 1 |
| Schepke, M | 1 |
| Strunk, H | 1 |
| Schild, H | 1 |
| Sauerbruch, T | 1 |
| Slanar, O | 1 |
| Aubrecht, J | 1 |
| Perlík, F | 1 |
| Sabba', C | 1 |
| Pugliese, D | 2 |
| Carbone, P | 1 |
| Altomare, E | 1 |
| Portincasa, P | 1 |
| Buonamico, P | 1 |
| Stufano, N | 1 |
| D'Ercole, M | 1 |
| Palasciano, G | 1 |
| Albano, O | 1 |
| Levacher, S | 2 |
| Letoumelin, P | 2 |
| Pateron, D | 1 |
| Blaise, M | 1 |
| Lapandry, C | 1 |
| Pourriat, JL | 2 |
| Bosch, J | 2 |
| Bruix, J | 1 |
| Mas, A | 2 |
| Navasa, M | 3 |
| Rodés, J | 2 |
| Kurokawa, H | 1 |
| Sekiyama, T | 1 |
| Katsuta, Y | 1 |
| Aramaki, T | 1 |
| Iwao, T | 4 |
| Toyonaga, A | 5 |
| Ikegami, M | 2 |
| Sumino, M | 4 |
| Oho, K | 2 |
| Sakaki, M | 2 |
| Shigemori, H | 1 |
| Nakayama, M | 1 |
| Tanikawa, K | 5 |
| D'Amico, G | 1 |
| Traina, M | 1 |
| Vizzini, G | 1 |
| Tinè, F | 1 |
| Politi, F | 1 |
| Montalbano, L | 1 |
| Luca, A | 1 |
| Pasta, L | 1 |
| Pagliaro, L | 1 |
| Morabito, A | 1 |
| Noguchi, H | 1 |
| Jones, AL | 1 |
| Hayes, PC | 2 |
| Silvain, C | 1 |
| Carpentier, S | 1 |
| Sautereau, D | 1 |
| Czernichow, B | 1 |
| Métreau, JM | 1 |
| Fort, E | 1 |
| Ingrand, P | 1 |
| Boyer, J | 1 |
| Pillegand, B | 1 |
| Doffël, M | 1 |
| Taura, P | 1 |
| Garcia-Valdecasas, JC | 1 |
| Beltran, J | 1 |
| Izquierdo, E | 1 |
| Sala-Blanch, J | 1 |
| Balust, J | 1 |
| Grande, L | 1 |
| Visa, J | 1 |
| Zoli, M | 1 |
| Magalotti, D | 1 |
| Ghigi, G | 1 |
| Marchesini, G | 1 |
| Pisi, E | 1 |
| Sugano, S | 2 |
| Suzuki, T | 2 |
| Nishio, M | 2 |
| Makino, H | 2 |
| Okajima, T | 1 |
| Masuko, E | 1 |
| Homma, H | 1 |
| Ohta, H | 1 |
| Nojiri, S | 1 |
| Koyama, R | 1 |
| Niitsu, Y | 1 |
| Combier, E | 1 |
| Joseph, A | 1 |
| de Pouvourville, G | 1 |
| Acalovschi, M | 1 |
| Spirchez, Z | 1 |
| Hamoudi, WT | 1 |
| Gaenzer, H | 1 |
| Sturm, W | 1 |
| Neumayr, G | 1 |
| Vogel, W | 1 |
| Patsch, J | 1 |
| Nishizono, M | 1 |
| Takagi, K | 2 |
| Ohkubo, K | 2 |
| Inoue, R | 2 |
| Yang, SS | 1 |
| Ralls, PW | 1 |
| Korula, J | 1 |
| Lin, HC | 2 |
| Tsai, YT | 2 |
| Lee, FY | 2 |
| Chang, TT | 2 |
| Wang, SS | 2 |
| Lay, CS | 2 |
| Lee, SD | 2 |
| Lo, KJ | 2 |
| Tabuchi, H | 1 |
| Kawai, N | 1 |
| Nagasaka, Y | 1 |
| García-Pagán, JC | 1 |
| Feu, F | 1 |
| Bru, C | 1 |
| Ruiz del Arbol, L | 1 |
| Moreau, R | 1 |
| Lee, SS | 2 |
| Hadengue, A | 2 |
| Ozier, Y | 1 |
| Sicot, C | 1 |
| Lebrec, D | 2 |
| Jiron, MI | 1 |
| Cerini, R | 1 |
| Westaby, D | 1 |
| Gimson, A | 1 |
| Williams, R | 1 |
| Sukigara, M | 1 |
| Shimoji, K | 1 |
| Ohata, M | 1 |
| Matsumoto, T | 1 |
| Komazaki, T | 1 |
| Matsumura, M | 1 |
| Itoh, S | 1 |
| Omoto, R | 1 |
| Kontturi, M | 1 |
| Sotaniemi, E | 1 |
| Ahlqvist, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903): A Multicenter, Single-blind, Randomised Controlled Trial[NCT04028323] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-07-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitroglycerin and Liver Cirrhosis
| Article | Year |
|---|---|
Rolling review: the treatment of major complications of cirrhosis.
Topics: Adrenergic beta-Antagonists; Ascites; Carcinoma, Hepatocellular; Catheterization; Diuretics; Hemorrh | 1994 |
Organic nitrates in portal hypertension.
Topics: Animals; Collateral Circulation; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans | 1994 |
12 trials available for nitroglycerin and Liver Cirrhosis
| Article | Year |
|---|---|
Hemodynamic effects of propranolol and nitrates in cirrhotics with transjugular intrahepatic portosystemic stent-shunt.
Topics: Blood Pressure; Drug Combinations; Female; Heart Rate; Hemodynamics; Humans; Hypertension, Portal; L | 2002 |
Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients.
Topics: Adult; Aged; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; G | 1995 |
Portal and systemic hemodynamic responses to a very low dose of nitroglycerin in cirrhotic patients with portal hypertension.
Topics: Female; Hemodynamics; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Male; Middle | 1995 |
Terlipressin or vasopressin plus transdermal nitroglycerin in a treatment strategy for digestive bleeding in cirrhosis. A randomized clinical trial. Liver Study Group of V. Cervello Hospital.
Topics: Administration, Cutaneous; Adult; Aged; Drug Therapy, Combination; Esophageal and Gastric Varices; F | 1994 |
Terlipressin plus transdermal nitroglycerin vs. octreotide in the control of acute bleeding from esophageal varices: a multicenter randomized trial.
Topics: Administration, Cutaneous; Adult; Aged; Blood Pressure; Drug Therapy, Combination; Emergencies; Esop | 1993 |
Chronic splanchnic hemodynamic effects of low-dose transdermal nitroglycerin versus low-dose transdermal nitroglycerin plus spironolactone in patients with cirrhosis.
Topics: Administration, Cutaneous; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esopha | 1997 |
Cost-effectiveness analysis of the terlipressin-glycerin trinitrate combination in the pre-hospital management of acute gastro-intestinal haemorrhage in cirrhotic patients.
Topics: Acute Disease; Antihypertensive Agents; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Co | 1999 |
Hemodynamic study during transdermal application of nitroglycerin tape in patients with cirrhosis.
Topics: Administration, Cutaneous; Aged; Female; Hemodynamics; Humans; Liver Circulation; Liver Cirrhosis; M | 1991 |
The effect of oral nitroglycerin on portal blood velocity as measured by ultrasonic Doppler. A double blind, placebo controlled study.
Topics: Administration, Oral; Blood Flow Velocity; Double-Blind Method; Female; Humans; Liver Cirrhosis; Mal | 1991 |
Effect of intraportal nitroglycerin on portosystemic hemodynamics in patients with cirrhosis: comparison with i.v. route.
Topics: Administration, Oral; Administration, Sublingual; Blood Pressure; Female; Hemodynamics; Humans; Hype | 1991 |
Long-term haemodynamic effects of isosorbide 5-mononitrate in patients with cirrhosis and portal hypertension.
Topics: Administration, Oral; Aged; Blood Pressure; Double-Blind Method; Female; Hemodynamics; Humans; Hyper | 1990 |
Haemodynamic response to intravenous vasopressin and nitroglycerin in portal hypertension.
Topics: Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hemodynamics; Humans; Hypertension, | 1988 |
19 other studies available for nitroglycerin and Liver Cirrhosis
| Article | Year |
|---|---|
Improvement of hepatocyte transplantation efficiency in the mdr2-/- mouse model by glyceryl trinitrate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Noninvasive evaluation of portal-systemic shunting by glyceryl trinitrate.
Topics: Administration, Oral; Administration, Sublingual; Adult; Diagnosis, Computer-Assisted; Female; Human | 2002 |
[Strain-gauge plethysmographic measurement of the systemic bioavailability of oral nitroglycerin in liver cirrhosis].
Topics: Administration, Oral; Adult; Aged; Biological Availability; Electrocardiography; Female; Humans; Liv | 1983 |
Wedged hepatic venous pressure reflects portal venous pressure during vasoactive drug administration in nonalcoholic cirrhosis.
Topics: Female; Hepatic Veins; Hepatitis B; Hepatitis C; Humans; Liver Cirrhosis; Male; Middle Aged; Nitrogl | 1994 |
Influence of nitroglycerin on portal pressure and gastric mucosal hemodynamics in patients with cirrhosis.
Topics: Adult; Aged; Female; Gastric Mucosa; Hemodynamics; Humans; Hypertension, Portal; Liver Cirrhosis; Ma | 1994 |
Moderate primary pulmonary hypertension in patients undergoing liver transplantation.
Topics: Adult; Blood Pressure; Cardiac Output; Cardiopulmonary Bypass; Case-Control Studies; Central Venous | 1996 |
Transdermal nitroglycerin in cirrhosis. A 24-hour echo-Doppler study of splanchnic hemodynamics.
Topics: Administration, Cutaneous; Adult; Aged; Analysis of Variance; Blood Flow Velocity; Circadian Rhythm; | 1996 |
Relationship of portal pressure and colorectal vasculopathy in patients with cirrhosis.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Colon; Female; Humans; Intestinal Mucosa; Liv | 1999 |
Rheologic analysis of gastric mucosal hemodynamics in patients with cirrhosis.
Topics: Endoscopy, Digestive System; Erythrocyte Volume; Female; Gastric Mucosa; Hemodynamics; Humans; Laser | 1999 |
Gallbladder hyporesponsiveness to an exogenous nitric oxide donor, glyceryl trinitrate, in patients with advanced liver cirrhosis.
Topics: Female; Gallbladder Emptying; Humans; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide Donors; Nitro | 1999 |
Hyperdynamic circulation in liver cirrhosis: no evidence for peripheral vasodilation detected by ultrasound of the brachial artery.
Topics: Adult; Aged; Blood Pressure; Brachial Artery; Female; Heart Rate; Humans; Hypertension, Portal; Live | 2000 |
Portohepatic pressures, hepatic function, and blood gases in the combination of nitroglycerin and vasopressin: search for additive effects in cirrhotic portal hypertension.
Topics: Aged; Catheterization, Peripheral; Child; Drug Therapy, Combination; Esophageal and Gastric Varices; | 1992 |
Systemic and portal haemodynamic changes following triglycyllysine vasopressin plus nitroglycerin administration in patients with hepatitis B-related cirrhosis.
Topics: Adult; Aged; Drug Combinations; Hemodynamics; Hepatitis B; Humans; Injections, Intravenous; Liver; L | 1990 |
[Favorable effect of long-term oxygen and vasodilator therapy in a patient with pulmonary hypertension associated with liver cirrhosis].
Topics: Humans; Hypertension, Pulmonary; Liver Cirrhosis; Male; Middle Aged; Nitroglycerin; Oxygen Inhalatio | 1990 |
Relationship between oxygen transport and oxygen uptake in patients with cirrhosis: effects of vasoactive drugs.
Topics: Biological Transport; Cardiac Output; Dobutamine; Hemodynamics; Humans; Infusions, Intravenous; Inje | 1989 |
Haemodynamic effects of triglycyl-lysine vasopressin plus nitroglycerin in patients with HBsAg-positive cirrhosis.
Topics: Drug Synergism; Hemodynamics; Hepatitis B Surface Antigens; Humans; Liver Cirrhosis; Lypressin; Nitr | 1989 |
Effects of nitroglycerin on forearm haemodynamics in patients with cirrhosis.
Topics: Adolescent; Adult; Aged; Aging; Female; Forearm; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle | 1988 |
Effects of propranolol and nitroglycerin on cephalad collateral venous flow in patients with cirrhosis: evaluation using transesophageal real-time two-dimensional Doppler echography.
Topics: Aged; Aorta; Azygos Vein; Blood Flow Velocity; Collateral Circulation; Color; Female; Humans; Hypert | 1988 |
Liver damage and estrogen therapy of prostatic cancer. Case report.
Topics: Adenocarcinoma; Aged; Blood Glucose; Carbutamide; Diabetes Mellitus; Diethylstilbestrol; Digoxin; Dr | 1972 |